Cluster_566081 V1000001 RPSI map03010 J 30S ribosomal protein S9 COG0103 Cluster_308979 V1000002 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_578689 V1000003 RPLQ map03010 J 50S ribosomal protein l17 COG0203 Cluster_239593 V1000004 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_572374 V1000005 RPSK map03010 J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) COG0100 Cluster_916651 V1000006 RPMJ map03010 J 50S ribosomal protein L36 COG0257 Cluster_740635 V1000007 INFA J however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) COG0361 Cluster_378421 V1000008 ADK map00230,map00240,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_522455 V1000009 RPLO map03010 J Binds to the 23S rRNA (By similarity) COG0200 Cluster_823744 V1000010 RPMD map03010 J 50S ribosomal protein L30 COG1841 Cluster_605875 V1000011 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_452466 V1000012 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_562868 V1000013 RPSH map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) COG0096 Cluster_595164 V1000014 RPLN map03010 J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) COG0093 Cluster_724090 V1000015 RPSQ map03010 J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal COG0186 Cluster_823745 V1000016 RPMC map03010 J 50s ribosomal protein l29 COG0255 Cluster_525339 V1000017 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_364903 V1000018 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_613186 V1000019 RPLV map03010 J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) COG0091 Cluster_704557 V1000020 RPSS map03010 J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) COG0185 Cluster_390768 V1000021 RPLC map03010 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 Cluster_673051 V1000022 RPSJ map03010 J Involved in the binding of tRNA to the ribosomes (By similarity) COG0051 Cluster_218189 V1000023 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_109296 V1000024 GLMU map00520,map01100,map01110 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) COG1207 Cluster_750662 V1000025 VEG S Veg protein COG4466 Cluster_261405 V1000026 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_430528 V1000027 RNMV L Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) COG1658 Cluster_313379 V1000028 TATD L Hydrolase, tatD family COG0084 Cluster_504128 V1000034 GREA2 K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) COG0782 Cluster_126642 V1000037 PEPC E aminopeptidase c COG3579 Cluster_149426 V1000038 YTTB G Major Facilitator 0ZVV9 Cluster_343780 V1000039 NRDG O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) COG0602 Cluster_32811 V1000040 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_343781 V1000041 GLPF G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) COG0580 Cluster_103300 V1000042 S M protein trans-acting positive regulator 11T9C Cluster_125280 V1000043 S oxidoreductase COG0446 Cluster_45525 V1000044 ASNB map00250,map00910,map01100,map01110,map01120 E asparagine synthetase COG0367 Cluster_491531 V1000046 T Universal stress protein COG0589 Cluster_300512 V1000047 PTP3 T protein tyrosine serine phosphatase COG2365 Cluster_272064 V1000048 K Transcriptional regulator 0Y1S3 Cluster_368272 V1000049 S NA 0Z3EH Cluster_98837 V1000050 S NA 11VH8 Cluster_272065 V1000051 K Inherit from COG: Transcriptional regulator COG1396 Cluster_327241 V1000052 CLVE map02010 S NA 11PT3 Cluster_419229 V1000053 S NA 0ZX1V Cluster_369947 V1000056 K transcriptional regulator 0ZMZA Cluster_219398 V1000057 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_374919 V1000058 S alpha beta COG0596 Cluster_297901 V1000059 EPSV M glycosyltransferase group 2 family protein COG0463 Cluster_378423 V1000060 map03030 S Caulimovirus viroplasmin COG3341 Cluster_75080 V1000061 GLNP E ABC transporter COG0834 Cluster_380127 V1000062 map00230,map00240,map00760,map01100,map01110 F UPF0207 protein COG1896 Cluster_258786 V1000063 HTPX map00900 O Protease HtpX homolog COG0501 Cluster_440476 V1000064 YKOE S ABC superfamily ATP binding cassette transporter membrane protein COG4721 Cluster_111916 V1000065 YKOD map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_162712 V1000066 HTRA O serine protease COG0265 Cluster_292333 V1000067 VICX map03013 S domain protein COG1235 Cluster_121261 V1000068 YYCH S YycH protein COG4863 Cluster_53005 V1000069 VICK map02020 T Histidine kinase 0XNMH Cluster_93196 V1000071 XASA E amino acid COG0531 Cluster_354987 V1000072 YFNB map00361,map00625,map01100,map01120 S Hydrolase COG1011 Cluster_519768 V1000073 NRDI F Probably involved in ribonucleotide reductase function (By similarity) COG1780 Cluster_49320 V1000074 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_591772 V1000075 RNPA J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) COG0594 Cluster_170975 V1000077 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_747298 V1000078 YAAA S S4 domain protein YaaA COG2501 Cluster_23553 V1000079 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_691077 V1000080 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_41483 V1000081 YYBT T domain protein COG3887 Cluster_111917 V1000082 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_161871 V1000083 SP_1634 S Protein of unknown function (DUF2974) 0XSVF Cluster_581900 V1000084 K Transcriptional regulator 0Y1S3 Cluster_147916 V1000085 G Major Facilitator 12APV Cluster_186258 V1000086 YUFN S basic membrane COG1744 Cluster_179312 V1000087 YUFP S ABC transporter (Permease COG4603 Cluster_381915 V1000088 DCK map00230,map00240,map01100 F deoxynucleoside kinase COG1428 Cluster_369948 V1000089 DCK map00230,map00240,map01100 F deoxynucleoside kinase COG1428 Cluster_126643 V1000090 PBUG S Xanthine uracil vitamin C permease COG2252 Cluster_167473 V1000091 S NA 11V0R Cluster_150272 V1000092 DLTB map05150 M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_29043 V1000093 DLTD map05150 M D-alanyl-lipoteichoic acid biosynthesis protein DltD COG3966 Cluster_605876 V1000094 S domain protein 11NZ4 Cluster_446523 V1000095 S NA 11H60 Cluster_406665 V1000097 LEPB map03060 U Signal peptidase i COG0681 Cluster_104454 V1000098 SUN map00340,map00350,map00624,map01120 J NOL1 NOP2 sun family protein COG0144 Cluster_190588 V1000099 MVAK2 map00900,map01100,map01110 I Phosphomevalonate kinase COG1577 Cluster_247479 V1000100 MVK map00900,map01100,map01110,map04146 I mevalonate kinase COG1577 Cluster_7646 V1000101 ADDB L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination COG3857 Cluster_6435 V1000102 ADDA L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation COG1074 Cluster_392559 V1000103 NTH map03410 L endonuclease III COG0177 Cluster_413945 V1000104 RECU S Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) COG3331 Cluster_446524 V1000105 YPSA S UPF0398 protein COG4474 Cluster_67437 V1000106 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_491532 V1000107 LSPA map03060 M, U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) COG0597 Cluster_456445 V1000108 HSLV O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) COG5405 Cluster_125954 V1000109 TRMFO J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) COG1206 Cluster_761252 V1000110 S UPF0346 protein COG4479 Cluster_277417 V1000111 ORF3 S degv family COG1307 Cluster_714178 V1000112 HUP L DNA-binding protein COG0776 Cluster_122684 V1000113 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_340702 V1000114 RLUB J Pseudouridine synthase COG1187 Cluster_334679 V1000115 SCPA S Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) COG1354 Cluster_58740 V1000116 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG3848 Cluster_244893 V1000117 RNZ map03013 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) COG1234 Cluster_47242 V1000118 OATA I Acyl-transferase COG1835 Cluster_364904 V1000119 SDAAB map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase, iron-sulfur-dependent, beta subunit COG1760 Cluster_415759 V1000120 ENGB S Necessary for normal cell division and for the maintenance of normal septation (By similarity) COG0218 Cluster_128738 V1000121 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_157617 V1000122 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_720713 V1000123 RPSO map03010 J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) COG0184 Cluster_737139 V1000124 RPST map03010 J Binds directly to 16S ribosomal RNA (By similarity) COG0268 Cluster_29280 V1000125 COMEC S Competence protein COG2333 Cluster_203713 V1000126 YLBL T domain protein COG3480 Cluster_475193 V1000127 COAD map00770,map01100 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) COG0669 Cluster_440477 V1000128 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_48927 V1000129 TYPA T gtp-binding protein typa COG1217 Cluster_389023 V1000130 S tpr repeat-containing protein 11U03 Cluster_473068 V1000131 FOLA map00670,map00790,map01100 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) COG0262 Cluster_29044 V1000132 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 Cluster_358403 V1000133 SRTA M (sortase) family COG3764 Cluster_440478 V1000134 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_660224 V1000135 J Ribosomal protein L7Ae/L30e/S12e/Gadd45 family COG1358 Cluster_691078 V1000136 YLXR K Nucleic-acid-binding protein implicated in transcription termination COG2740 Cluster_175971 V1000137 NUSA K Transcription elongation factor NusA COG0195 Cluster_454505 V1000138 RIMP S Required for maturation of 30S ribosomal subunits (By similarity) COG0779 Cluster_4071 V1000139 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_60898 V1000140 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_301926 V1000141 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_337731 V1000142 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_265390 V1000143 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_313380 V1000144 RPSB map03010 J 30S ribosomal protein S2 COG0052 Cluster_204827 V1000145 YABB map00340,map00350,map00624,map01120 L Methyltransferase COG4123 Cluster_59025 V1000146 MDLA map02010 V ABC transporter transmembrane region COG1132 Cluster_776485 V1000147 YNEF S UPF0154 protein COG3763 Cluster_417528 V1000148 LEXA K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) COG1974 Cluster_308980 V1000149 S NA 11Q2H Cluster_342171 V1000150 TRMD map00900,map01100,map01110 J Specifically methylates guanosine-37 in various tRNAs (By similarity) COG0336 Cluster_717451 V1000151 RPSP map03010 J 30s ribosomal protein S16 COG0228 Cluster_101025 V1000152 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_616926 V1000153 YLXM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) COG2739 Cluster_67093 V1000154 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_270768 V1000155 ISPA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_115406 V1000156 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_559995 V1000157 NUSB K Involved in the transcription termination process (By similarity) COG0781 Cluster_548207 V1000158 ASP S alkaline shock protein COG1302 Cluster_180149 V1000159 PEPP map00310,map00780,map01100 E peptidase M24 COG0006 Cluster_462529 V1000160 S response regulator receiver protein 1261B Cluster_328802 V1000161 YVFS map02010 V ABC transporter COG0842 Cluster_172686 V1000162 FOLP map00790,map01100 H dihydropteroate synthase COG0294 Cluster_408408 V1000163 F Ham1 family COG0127 Cluster_432526 V1000164 FOLE map00790,map01100 H GTP cyclohydrolase i COG0302 Cluster_635829 V1000165 FOLB map00790,map01100 H dihydroneopterin aldolase COG1539 Cluster_430529 V1000166 NUDF map00230 F nudix hydrolase COG0494 Cluster_779996 V1000167 CSPA K Cold shock protein COG1278 Cluster_13614 V1000168 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_6916 V1000169 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_363199 V1000170 RNC map03008,map05205 K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) COG0571 Cluster_60338 V1000171 OPPA E ABC transporter COG0747 Cluster_243615 V1000172 APPC map02010 P ABC superfamily ATP binding cassette transporter ABC protein COG1173 Cluster_41188 V1000173 RECG map03440 L ATP-dependent DNA helicase recG COG1200 Cluster_554065 V1000174 ASP S Alkaline-shock protein COG1302 Cluster_784290 V1000175 RPMB map03010 J 50S ribosomal protein l28 COG0227 Cluster_385450 V1000176 ARTM E amino acid AbC transporter COG0765 Cluster_285599 V1000177 GLNH map02010,map02020 E, T (ABC) transporter COG0834 Cluster_186259 V1000178 FRVX map00500,map01100 E Peptidase m42 family protein COG1363 Cluster_155117 V1000179 SBND G Major Facilitator 0ZVCH Cluster_125955 V1000180 PYRP F permease COG2233 Cluster_243616 V1000181 V abc transporter atp-binding protein COG1131 Cluster_319618 V1000182 SP_1071 S abc transporter atp-binding protein COG1101 Cluster_217069 V1000183 ATU2672 S ABC transporter COG2984 Cluster_150273 V1000184 S Bacteriophage peptidoglycan hydrolase 0ZNE8 Cluster_73773 V1000185 DEXB map00052,map00500,map01100 G trehalose-6-phosphate hydrolase (EC 3.2.1.93) COG0366 Cluster_356693 V1000186 map02010 P Cobalt transport protein COG0619 Cluster_403137 V1000187 SLGD_00062 S membrAne 11F2H Cluster_858365 V1000188 S NA 0ZG62 Cluster_33734 V1000194 S NA 1291J Cluster_39263 V1000195 M Minor structural protein 0XPF3 Cluster_12950 V1000196 S Inherit from NOG: Tail protein 11MY0 Cluster_668766 V1000197 S NA 0Z7IV Cluster_424731 V1000198 S tail protein 0Y1BD Cluster_140355 V1001803 ACIN_0074 L Transposase COG3464 Cluster_448546 V1001805 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_321060 V1001806 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_141829 V1001807 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_895371 V1001809 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_677532 V1001810 YRZB S UPF0473 protein COG3906 Cluster_542199 V1001811 RUVX L Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) COG0816 Cluster_724093 V1001812 YRZL S UPF0297 protein COG4472 Cluster_287024 V1001814 FBA map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01230 G fructose-bisphosphate aldolase COG0191 Cluster_213573 V1001815 INSI L transposase COG2826 Cluster_92273 V1001818 ADHE map00010,map00051,map00071,map00350,map00362,map00363,map00591,map00620,map00621,map00622,map00625,map00626,map00650,map01100,map01110,map01120 C Aldehyde-alcohol dehydrogenase 2 COG1454 Cluster_385453 V1001819 SITA map02010,map02020 P periplasmic solute binding protein COG0803 Cluster_288428 V1001820 SITC map02010,map02020 P ABC transporter COG1108 Cluster_232170 V1001821 S NA 0YIYD Cluster_194216 V1001822 PEPA map00500,map01100 E Peptidase m42 family protein COG1363 Cluster_136516 V1001824 PURB map00230,map00250,map01100,map01110 F adenylosuccinate lyase COG0015 Cluster_268089 V1001825 SDAA map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase COG1760 Cluster_784293 V1001826 PPAX map00190,map00230,map00240,map00630,map00760,map01100,map01110 S Hydrolase COG0546 Cluster_130984 V1001827 S tail tape measure protein COG5280 Cluster_850755 V1001828 S NA 0Z81M Cluster_496488 V1001829 GPSA map00564 C NADPH-dependent glycerol-3-phosphate dehydrogenase COG0240 Cluster_252461 V1001830 GALU map00040,map00052,map00500,map00520,map01100,map01110 M UTP-glucose-1-phosphate uridylyltransferase COG1210 Cluster_240891 V1001831 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate (By similarity) COG0167 Cluster_301931 V1001833 PTS-EIID map00051,map00520,map01100,map02060 G PTS System COG3716 Cluster_556946 V1001834 map00051,map00520,map01100,map02060 G PTS system fructose IIA component COG2893 Cluster_883156 V1001835 AGAS map00250,map00520,map01100,map01110 M isomerase COG2222 Cluster_247485 V1001836 S Domain of unknown function (DUF1837) 100DA Cluster_422966 V1001837 FOLP map00790,map01100 H dihydropteroate synthase COG0294 Cluster_278805 V1001838 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0302 Cluster_426616 V1001839 TATD L Hydrolase, tatD family COG0084 Cluster_891104 V1001840 RPMH map03010 J 50S ribosomal protein l34 COG0230 Cluster_466663 V1001841 S NA 12D34 Cluster_103301 V1001842 FUCA map00511 G Alpha-L-fucosidase COG3669 Cluster_272071 V1001843 DEGV S degv family COG1307 Cluster_466664 V1001844 YACP J Tetracycline resistance protein COG3688 Cluster_264043 V1001845 HUTU map00340,map01100 E Urocanate hydratase COG2987 Cluster_643819 V1001846 HUTI map00340,map01100 Q imidazolone-5-propionate hydrolase COG1228 Cluster_104458 V1001847 S Transglycosylase SLT domain COG5283 Cluster_397921 V1001848 VRAR map02020 T response regulator COG2197 Cluster_304852 V1001849 VRAS map02020 T Histidine kinase COG4585 Cluster_163524 V1001850 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_127350 V1001851 MALF map02010 P binding-protein-dependent transport systems inner membrane Component 0Y7BF Cluster_107505 V1001852 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG1640 Cluster_899481 V1001853 COMGB U Competence protein COG1459 Cluster_660226 V1001854 COMGC U comG operon protein 3 COG4537 Cluster_556947 V1001855 S NA 11EW3 Cluster_664447 V1001857 COMGF U comG operon protein 6 COG4940 Cluster_281441 V1001860 map00051,map00520,map01100,map02060 G PTS System COG3715 Cluster_506611 V1001861 LEVD map00051,map00520,map01100,map02060 G pts system COG3716 Cluster_479773 V1001862 SP_1785 S Protein of unknown function (DUF3013) 1289G Cluster_232171 V1001866 LYC M glycoside hydrolase, family 25 11T0J Cluster_289735 V1001867 DLTD map05150 M D-alanyl-lipoteichoic acid biosynthesis protein DltD COG3966 Cluster_754099 V1001868 DLTC map00473,map05150 H Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) COG0236 Cluster_677533 V1001869 DLTB map05150 M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_373220 V1001870 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_345389 V1001871 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_136517 V1001872 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_116880 V1001874 LLDP C L-lactate COG1620 Cluster_620693 V1001875 SP_0092 G extracellular solute-binding protein family 1 COG1653 Cluster_242244 V1001876 LPLC G Binding-protein-dependent transport systems, inner membrane component COG0395 Cluster_651939 V1001877 S Ion channel 1202Y Cluster_114045 V1001878 MNGB map00511 G hydrolase, family 38 COG0383 Cluster_191484 V1001879 ADH map00010,map00051,map00071,map00350,map00363,map00591,map00625,map00626,map00650,map00830,map00980,map00982,map01100,map01110,map01120 C alcohol dehydrogenase COG1063 Cluster_392562 V1001880 S NA 0YNCM Cluster_468841 V1001881 S NA 0Y2WH Cluster_448547 V1001882 I esterase COG0657 Cluster_295132 V1001883 LSA S (ABC) transporter COG0488 Cluster_117573 V1001884 ANSP E amino acid COG1113 Cluster_374924 V1001885 NTPJ P Potassium uptake protein COG0168 Cluster_369952 V1001886 KTRA P domain protein COG0569 Cluster_446528 V1001888 PGSA map00564,map01100 I cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase COG0558 Cluster_426617 V1001889 ECFA1 map02010 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates COG1122 Cluster_356699 V1001890 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_536611 V1001891 RPLK map03010 J This protein binds directly to 23S ribosomal RNA (By similarity) COG0080 Cluster_120456 V1001892 PFLB map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_883157 V1001893 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_178469 V1001894 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_371592 V1001895 YYBT T domain protein COG3887 Cluster_165186 V1001896 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_366647 V1001897 SDAAB map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase, iron-sulfur-dependent, beta subunit COG1760 Cluster_542200 V1001898 SDAA map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase COG1760 Cluster_717455 V1001899 GTF1 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) COG0438 Cluster_682095 V1001900 GATC map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0721 Cluster_750667 V1001901 GATA map00970,map01100 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) COG0154 Cluster_448548 V1001902 APF1 S Lysm domain protein 11U6T Cluster_126646 V1001903 S NA 0YA5W Cluster_491541 V1001905 S NA 0ZGFA Cluster_158500 V1001908 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_264044 V1001912 P cation diffusion facilitator family transporter COG1230 Cluster_701561 V1001913 K Bacterial regulatory proteins, tetR family COG1309 Cluster_146347 V1001914 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_166722 V1001915 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_328805 V1001916 SUFS map00450,map00730,map01100 E Cysteine desulfurase COG0520 Cluster_450526 V1001917 SUFD O feS assembly protein SufD COG0719 Cluster_691084 V1001918 J s4 domain protein COG1188 Cluster_595173 V1001919 DIVIC D Septum formation initiator COG2919 Cluster_835222 V1001922 METQ map02010 P Lipoprotein COG1464 Cluster_203715 V1001923 DAPE map00300,map01100,map01120,map01230 E peptidase COG0624 Cluster_214764 V1001924 map00860,map01100,map01110 S decarboxylase 11UPA Cluster_403140 V1001927 S NA 1269Y Cluster_165985 V1001928 YBIT S ABC transporter, ATP-binding protein COG0488 Cluster_189699 V1001929 GLGA map00500,map01100,map01110,map04973 G Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) COG0297 Cluster_823752 V1001930 GLGD map00500,map00520,map01100,map01110 M glucose-1-phosphate adenylyltransferase, glgd subunit COG0448 Cluster_265399 V1001931 PEPQ map00310,map00780,map01100 E peptidase M24 COG0006 Cluster_575626 V1001932 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_141830 V1001933 PCNA map03013,map03018 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate COG0617 Cluster_691085 V1001934 MANY map00051,map00520,map01100,map02060 G PTS System COG3715 Cluster_233466 V1001935 map00051,map00520,map01100,map02060 G component COG3444 Cluster_147922 V1001936 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_143326 V1001938 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_144807 V1001939 map00511 G glycoside hydrolase family 38 COG0383 Cluster_664448 V1001941 RV2901C S Protein of unknown function (DUF2469) 11N6F Cluster_151076 V1001942 S Transglycosylase SLT domain COG5283 Cluster_337737 V1001943 SUFC O feS assembly ATPase SufC COG0396 Cluster_161873 V1001944 SP_0341 S UPF0371 protein COG4868 Cluster_340713 V1001945 M Bacteriophage peptidoglycan hydrolase COG0791 Cluster_780002 V1001946 HOL S holin, phage phi LC3 family COG5546 Cluster_314985 V1001948 RNJB map03018 O Metallo-Beta-Lactamase COG0595 Cluster_545167 V1001949 ESTA S esterase COG0627 Cluster_269474 V1001950 S Phage portal protein 0XNRQ Cluster_562874 V1001952 SPXA_1 K transcriptional regulator, Spx COG1393 Cluster_522462 V1001953 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_765228 V1001954 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_157621 V1001955 YHGE S domain protein COG1511 Cluster_290997 V1001956 VEX3 V abc transporter permease protein COG0577 Cluster_585164 V1001957 VEX2 V abc transporter atp-binding protein COG1136 Cluster_232172 V1001959 NIST map02010 V ABC transporter 0XPIZ Cluster_940891 V1001960 SP_1785 S Protein of unknown function (DUF3013) 1289G Cluster_203716 V1001961 RARA L recombination factor protein RarA COG2256 Cluster_229842 V1001963 PURM map00230,map01100,map01110 F phosphoribosylaminoimidazole synthetase COG0150 Cluster_171788 V1001964 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_569187 V1001965 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_251281 V1001968 GLYQ map00970 J glycyl-tRNA synthetase, alpha subunit COG0752 Cluster_155122 V1001969 map00564 C glycerophosphoryl diester phosphodiesterase COG0584 Cluster_196776 V1001971 ADH map00010,map00051,map00071,map00350,map00363,map00591,map00625,map00626,map00650,map00830,map00980,map00982,map01100,map01110,map01120 C alcohol dehydrogenase COG1063 Cluster_200701 V1001972 S Transporter Permease Protein 0ZURF Cluster_237008 V1001975 NRNA J phosphoesterase RecJ domain protein COG0618 Cluster_710737 V1001976 FABG map00061,map00780,map01040,map01100 I reductase 0XNW1 Cluster_277424 V1001977 FABF map00061,map00780,map01100 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) COG0304 Cluster_180151 V1001978 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_293712 V1001979 DNAB L replication initiation and membrane attachment COG3611 Cluster_158501 V1001981 map00310,map00780,map01100 E Dipeptidase COG4690 Cluster_374925 V1001982 CYLA map02010 V ABC transporter, ATP-binding protein COG1131 Cluster_452476 V1001983 CYLB map02010 V Transporter COG0842 Cluster_181836 V1001984 GDH map00250,map00330,map00430,map00910,map01100 E Dehydrogenase COG2902 Cluster_509239 V1001986 ADCR K Transcriptional 0XUB6 Cluster_850757 V1001987 DUSB J Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_261408 V1001988 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_819616 V1001989 M glycosyl transferase COG1819 Cluster_162713 V1001990 CTPE P Cation-transporting atpase COG0474 Cluster_324183 V1001991 FOLK map00790,map01100 H 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase COG1539 Cluster_569188 V1001992 FOLE map00790,map01100 H GTP cyclohydrolase i COG0302 Cluster_664449 V1001993 TRXA2 O Thioredoxin COG0526 Cluster_525341 V1001994 BAES map02020 T Histidine kinase 0XNMH Cluster_336240 V1001995 RBSB map02010,map02030 G Ribose ABC transporter COG1879 Cluster_916655 V1001996 SP_0119 L Nudix family COG0494 Cluster_252462 V1001997 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_264045 V1001998 FBA map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01230 G Aldolase COG0191 Cluster_470947 V1001999 M Transglutaminase-like superfamily 0XV6Q Cluster_486733 V1002000 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_525409 V1019801 YEIH S Membrane COG2855 Cluster_174361 V1019803 S NA 11JF2 Cluster_68487 V1019812 S NA 0ZHU8 Cluster_134931 V1019813 S tonB-dependent Receptor 0XNVP Cluster_424777 V1019814 PURN map00230,map00670,map01100,map01110 F phosphoribosylglycinamide formyltransferase COG0299 Cluster_306284 V1019815 S Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) COG1385 Cluster_698503 V1019816 S NA 0Z4BV Cluster_517238 V1019817 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_157642 V1019818 map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aminotransferase COG0436 Cluster_157643 V1019819 map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aminotransferase COG0436 Cluster_522521 V1019822 DPS P DNA protection during starvation protein COG0783 Cluster_557006 V1019823 S Protein of unknown function, DUF393 COG3011 Cluster_299209 V1019825 AROK map00400,map01100,map01110,map01230 E Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) COG0703 Cluster_77060 V1019827 NIKA map02010 E Nickel ABC transporter, periplasmic nickel-binding protein COG0747 Cluster_381952 V1019830 SP_1047 S NA 128UG Cluster_237051 V1019831 S Recombinase 0Y2JQ Cluster_403184 V1019832 RECR map03440 L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) COG0353 Cluster_162738 V1019833 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_128756 V1019834 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_714225 V1019835 CCU S Protein of unknown function (DUF1643) COG4333 Cluster_647914 V1019836 ORF010 S Staphylococcal protein of unknown function (DUF960) 1265C Cluster_303364 V1019838 L Resolvase COG1961 Cluster_812208 V1019841 YVLC S phage shock protein C, PspC COG1983 Cluster_186290 V1019845 YBHE S Outer surface protein COG3589 Cluster_530979 V1019846 NAGK G BadF BadG BcrA BcrD COG2971 Cluster_141149 V1019856 DCM2 map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_56425 V1019857 RPSA map00900,map01100,map01110,map03010 J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) COG0539 Cluster_163545 V1019858 ACDH map00071,map00280,map00281,map00650,map01100,map01110 I acyl-CoA dehydrogenase COG1960 Cluster_444546 V1019859 I MaoC like domain COG2030 Cluster_43105 V1019860 S NA 0YZ82 Cluster_270812 V1019863 REP L Replication Protein COG5527 Cluster_237052 V1019864 map00270,map00920,map01100,map01120,map01230 E serine O-acetyltransferase (EC 2.3.1.30) COG1045 Cluster_227534 V1019865 S DNA polymerase iii 101FB Cluster_509295 V1019866 P uptake regulation protein COG0735 Cluster_486775 V1019867 P sulfate transporter COG0659 Cluster_444547 V1019868 OCAR_4628 S HhH-GPD domain protein COG5483 Cluster_506666 V1019869 C Luciferase-like monooxygenase COG2141 Cluster_356748 V1019870 GLNR K transcriptional regulator COG0745 Cluster_366685 V1019871 S NA 11TYD Cluster_43282 V1019873 SASC S surface protein 11FPX Cluster_141847 V1019874 CCSB O Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) COG1333 Cluster_337793 V1019876 map02020 T regulator COG0745 Cluster_714226 V1019878 MOAA map00790,map01100,map04122 H Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) COG2896 Cluster_196792 V1019879 MOEB map00730,map01100,map04122 H uba thif-type nad fad binding protein COG0476 Cluster_468884 V1019880 MOAE map00790,map01100,map04122 H molybdopterin converting factor, large subunit COG0314 Cluster_203743 V1019885 KDPD map02020 T Histidine kinase COG2205 Cluster_353439 V1019886 KDPE map02020 T response regulator COG0745 Cluster_225293 V1019893 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_598850 V1019894 MOAB map00790,map01100,map04122 H Molybdenum cofactor synthesis domain protein COG0521 Cluster_765281 V1019895 S ThiS family 1026U Cluster_56731 V1019896 YFMR S ABC transporter, ATP-binding protein COG0488 Cluster_102156 V1019899 HSDM V type I restriction-modification system COG0286 Cluster_157644 V1019901 KBL map00260,map00780,map01100 E 2-amino-3-ketobutyrate coenzyme A ligase COG0156 Cluster_581974 V1019902 S conserved domain protein 0YM94 Cluster_545233 V1019904 K Transcriptional regulator, arsr family COG0640 Cluster_385503 V1019906 M Teichoic acid COG1887 Cluster_174362 V1019907 MNAA map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_346969 V1019908 S Beta-lactamase domain protein COG0491 Cluster_452513 V1019910 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_434457 V1019911 S NA 11ST2 Cluster_450558 V1019912 S Gtra family COG2246 Cluster_179342 V1019917 map00860,map01100 H cobaltochelatase, cobn subunit COG1429 Cluster_440525 V1019918 GPO map00480,map00590 O Glutathione peroxidase COG0386 Cluster_560059 V1019919 HYPA C Hydrogenase nickel incorporation protein COG0375 Cluster_284219 V1019921 MODF map02010 P ABC transporter COG1119 Cluster_413985 V1019922 COPA map00053,map01100 Q Multicopper oxidase COG2132 Cluster_288459 V1019923 SOJ D Chromosome Partitioning Protein COG1192 Cluster_134932 V1019924 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_578754 V1019926 GLPE P rhodanese-like protein COG0607 Cluster_501732 V1019927 S doxx family 0ZX2M Cluster_64788 V1019929 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_235868 V1019930 S alpha beta COG4757 Cluster_186291 V1019932 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_270813 V1019933 S NA 11MMW Cluster_554123 V1019935 HELY L helicase COG4581 Cluster_166007 V1019936 TATC map03060,map03070 U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) COG0805 Cluster_78720 V1019937 M Nlp p60 protein COG0791 Cluster_714228 V1019938 S NA 0ZHU9 Cluster_714229 V1019941 S NA 0ZHU9 Cluster_412065 V1019944 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_473117 V1019945 K lytTr DNA-binding domain protein 11WH8 Cluster_291043 V1019946 GPMB map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_588473 V1019949 YDII Q thioesterase Superfamily protein COG2050 Cluster_412066 V1019950 RPLY map03010 J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) COG1825 Cluster_200719 V1019951 NUSB K Involved in the transcription termination process (By similarity) COG0781 Cluster_397949 V1019952 TAG map03410 L Dna-3-methyladenine glycosylase i COG2818 Cluster_248822 V1019953 PANE map00770,map01100,map01110 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) COG1893 Cluster_581975 V1019954 S NA 0YIA5 Cluster_134120 V1019955 S Relaxase mobilization nuclease 0Y9PG Cluster_438549 V1019956 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_624487 V1019957 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_450559 V1019958 S NA 0YNFS Cluster_309015 V1019960 S Short chain dehydrogenase 11FE9 Cluster_361651 V1019961 ALKB L Alkylated DNA repair protein COG3145 Cluster_121273 V1019962 PEPC E aminopeptidase c COG3579 Cluster_118272 V1019963 U relaxase mobilization nuclease domain protein COG3843 Cluster_151088 V1019964 BMA1016 L transposase, IS204 IS1001 IS1096 IS1165 family protein COG3464 Cluster_816044 V1019965 S NA 0Z4XG Cluster_835265 V1019966 S YcfA-like protein 0ZAAU Cluster_470989 V1019967 S NA 0XWCR Cluster_765282 V1019968 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_199686 V1019969 NREB map02020 T Sensor histidine kinase 0XNMH Cluster_511882 V1019970 NREA map02020 S of nitrate reduction 11WUR Cluster_616992 V1019971 RPLU map03010 J This protein binds to 23S rRNA in the presence of protein L20 (By similarity) COG0261 Cluster_743917 V1019972 RPMA map03010 J 50S ribosomal protein l27 COG0211 Cluster_325724 V1019973 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_442548 V1019977 K regulatoR 0Y2NF Cluster_572438 V1019980 FDHD C Necessary for formate dehydrogenase activity (By similarity) COG1526 Cluster_333238 V1019981 T regulatoR 11ZQF Cluster_234679 V1019982 S ATPase domain protein 125CS Cluster_440526 V1019983 NUDF map00230 F nudix hydrolase COG0494 Cluster_121998 V1019984 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG0469 Cluster_300547 V1019985 GG9_0942 L transposase COG2801 Cluster_423002 V1019986 L Transposase 11M0T Cluster_591847 V1019987 YGDD S Membrane COG2363 Cluster_378471 V1019989 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_187169 V1019990 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_309016 V1019991 LPXA map00540,map01100 M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) COG1043 Cluster_598851 V1019992 SECG map03060,map03070 U Preprotein translocase SecG subunit 123GJ Cluster_192439 V1019993 ARGF map00330,map01100,map01110,map01230 E ornithine carbamoyltransferase COG0078 Cluster_171000 V1019994 M Glycosyl transferase, family 2 0ZNJT Cluster_46885 V1019997 L helicase COG4646 Cluster_117587 V1019998 YDIU S UPF0061 protein COG0397 Cluster_470990 V1019999 SGLY_0535 S phage protein 0XNW6 Cluster_711464 V1199802 YAFQ S addiction module toxin, RelE StbE family COG3041 Cluster_103417 V1199803 S NA 0XZ3T Cluster_330472 V1199804 S phage tail component 0Z5R7 Cluster_46353 V1199805 S tail tape measure protein COG5280 Cluster_487234 V1199806 S NA COG5412 Cluster_410658 V1199808 S NA 102R7 Cluster_224318 V1199811 S Structural protein 11PKS Cluster_391122 V1199813 S NA 11QJS Cluster_143461 V1199814 S NA 12BGZ Cluster_94684 V1199815 S Phage portal protein, SPP1 Gp6-like 11J8D Cluster_606717 V1199816 V Hnh endonuclease COG1403 Cluster_537270 V1199820 RUSA L endodeoxyribonuclease RusA COG4570 Cluster_430929 V1199822 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_352040 V1199823 BET L Phage recombination protein Bet 11G2M Cluster_312246 V1199825 K anti-repressor COG3645 Cluster_358742 V1199829 K HTH_XRE 0XUC3 Cluster_189873 V1199832 L Phage integrase COG0582 Cluster_2074 V1199833 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_17140 V1199834 XYLS map00052,map00500,map01100 G hydrolase, family 31 COG1501 Cluster_294015 V1199835 S TraX protein 100CF Cluster_64573 V1199836 MALL map00500,map01100 G Oligo-1-6-glucosidase COG0366 Cluster_30713 V1199837 MALQ map00500,map01100 G 4-alpha-glucanotransferase COG1640 Cluster_285909 V1199838 map02010 P ABC transporter COG0395 Cluster_100552 V1199839 AMYE map02010 G solute-binding protein COG1653 Cluster_363541 V1199840 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_86816 V1199841 P Chloride channel COG0038 Cluster_285910 V1199842 METQ map02010 P lipoprotein COG1464 Cluster_1723 V1199844 S NA 0YG6V Cluster_287312 V1199845 SUHB map00521,map00562,map01100,map01110,map04070 G inositol monophosphatase COG0483 Cluster_66854 V1199846 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_9180 V1199847 CAFA map03018 J ribonuclease COG1530 Cluster_101695 V1199849 D Maf-like protein COG0424 Cluster_110048 V1199850 HOM map00260,map00270,map00300,map01100,map01110,map01120,map01230 E homoserine dehydrogenase COG0460 Cluster_171140 V1199851 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_6683 V1199852 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_131886 V1199853 RUTG F permease COG2233 Cluster_322938 V1199854 SCLAV_2398 T response regulator COG2197 Cluster_327573 V1199856 YBHL S Membrane COG0670 Cluster_210465 V1199857 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_69600 V1199858 LMRB P drug resistance transporter, EmrB QacA subfamily 0XNN3 Cluster_239868 V1199859 RIHB map00230,map00240,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_417925 V1199860 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_252732 V1199861 TRMD map00900,map01100,map01110 J Specifically methylates guanosine-37 in various tRNAs (By similarity) COG0336 Cluster_408798 V1199862 RIMM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) COG0806 Cluster_73146 V1199863 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_96281 V1199864 PEPC E aminopeptidase c COG3579 Cluster_84711 V1199866 ULAA map00053,map01100,map01120,map02060 G PTS system ascorbate-specific transporter subunit IIC COG3037 Cluster_705253 V1199867 map00053,map01100,map01120,map02060 G IIb component COG3414 Cluster_69601 V1199868 PTSI map02060 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) COG1080 Cluster_13918 V1199869 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG1754 Cluster_161198 V1199870 S PAP2 superfamily 0XZ0P Cluster_283097 V1199871 MRAZ S Cell division protein mraZ COG2001 Cluster_182070 V1199872 RLUD J Pseudouridine synthase COG0564 Cluster_172866 V1199873 TRMI J tRNA (Adenine-N1-)-methyltransferase COG2519 Cluster_288670 V1199874 YEAZ O Peptidase M22 Glycoprotease COG1214 Cluster_54995 V1199875 map02010 G ABC transporter COG4213 Cluster_57269 V1199876 RHLE map03018 L Helicase COG0513 Cluster_73852 V1199877 S Membrane COG0628 Cluster_566833 V1199878 CPIN_3686 L Transposase (IS4 family COG3385 Cluster_218453 V1199880 S NA 10255 Cluster_164483 V1199881 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG0582 Cluster_173706 V1199882 TYRA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydrogenase COG0287 Cluster_25412 V1199885 PRIA map03440 L Primosomal protein n' COG1198 Cluster_151210 V1199886 AROE map00400,map01100,map01110,map01230 E shikimate COG0169 Cluster_207224 V1199887 YHBJ S Displays ATPase and GTPase activities (By similarity) COG1660 Cluster_283098 V1199888 S haloacid dehalogenase-like hydrolase COG0561 Cluster_72817 V1199889 map03440 K Transcriptional regulator 0XRI9 Cluster_95696 V1199890 S atpase, aaa COG1373 Cluster_94685 V1199891 SLGD_00086 S Ser Thr phosphatase family protein COG1409 Cluster_773494 V1199892 S helix-turn-helix domain protein 122WR Cluster_275046 V1199893 map03430 L Dna adenine methylase COG0338 Cluster_60387 V1199894 V ATPase associated with various cellular activities aaa_5 COG1401 Cluster_62897 V1199896 M Inherit from NOG: Lpxtg-motif cell wall anchor domain protein 0Y6CS Cluster_5318 V1199898 L DNA helicase COG1112 Cluster_100553 V1199899 PEPC E aminopeptidase c COG3579 Cluster_339 V1199900 S NA 101UU Cluster_196951 V1199901 ISPE map00900,map01100,map01110 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COG1947 Cluster_58794 V1199902 S integral membrane protein 0XS1S Cluster_475695 V1199908 S NA 123H2 Cluster_12252 V1199910 D cell division protein FtsK COG1674 Cluster_178613 V1199911 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_95201 V1199912 PIP map00330 L Prolyl aminopeptidase COG0596 Cluster_122145 V1199913 S NA 11FSG Cluster_824547 V1199914 S YcfA-like protein 0XX5U Cluster_4693 V1199917 S NA 11RGQ Cluster_392936 V1199919 S integral membrane protein COG4243 Cluster_72818 V1199920 MPHA S Aminoglycoside phosphotransferase 0YEJ0 Cluster_105181 V1199921 S DivIVA domain repeat protein 11XZ2 Cluster_85908 V1199922 GLYQS map00970 J Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) COG0423 Cluster_96282 V1199923 MVAA map00900,map01100,map01110,map04976 I hydroxymethylglutaryL-CoA reductase COG1257 Cluster_11575 V1199924 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_444925 V1199925 S NA 1AK94@sphNOG Cluster_98960 V1199928 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_227750 V1199929 APPB map02010 P Binding-protein-dependent transport systems inner membrane component COG0601 Cluster_16058 V1199931 map00760,map01100 H NAD synthase 1215K Cluster_628978 V1199932 XSEB map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) 121U6 Cluster_180314 V1199933 M Sortase family COG3764 Cluster_63742 V1199934 M Inherit from NOG: Lpxtg-motif cell wall anchor domain protein 0Y6CS Cluster_1891 V1199935 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_176118 V1199936 M Sortase family COG3764 Cluster_823 V1199937 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_327574 V1199938 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_201871 V1199939 DNAJ1 O DnaJ domain protein COG2214 Cluster_557623 V1199940 S kila-n, DNA-binding domain 0XPNQ Cluster_9302 V1199942 S NA 1278K Cluster_10329 V1199944 S NA 12BGB Cluster_231247 V1199945 XERD L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_473570 V1199946 YBAK S YbaK ebsC protein COG2606 Cluster_55492 V1199947 MURE map00300,map00550,map01100 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_77122 V1199948 PEPP E Xaa-Pro aminopeptidase COG0006 Cluster_257704 V1199949 map00051,map00500,map00520,map01100 G pfkb domain protein COG0524 Cluster_246468 V1199951 PLSC2 map00561,map00564,map01100 I Acyl-transferase COG0204 Cluster_199875 V1199952 THRB map00260,map01100,map01120,map01230 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) COG0083 Cluster_91856 V1199953 D Maf-like protein COG0424 Cluster_678501 V1199955 YHBY J Rna-binding protein COG1534 Cluster_25307 V1199956 RV2326C map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_70886 V1199957 PCCB map00280,map00630,map00640,map00720,map01100,map01120 I carboxyl transferase COG4799 Cluster_279048 V1199958 GLNR K transcriptional regulator COG0745 Cluster_162028 V1199959 map00051 M glycosyltransferase group 2 family protein COG0463 Cluster_135871 V1199960 S Virulence-associated protein e COG5545 Cluster_48314 V1199962 MOD map00340,map00350,map00624,map01120 L DNA methylase COG2189 Cluster_440925 V1199963 SCLAV_4550 L UPF0102 protein COG0792 Cluster_45359 V1199964 SDHA map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map05134 C Succinate dehydrogenase (Flavoprotein subunit) COG1053 Cluster_336559 V1199965 K GntR Family Transcriptional Regulator COG2188 Cluster_21848 V1199966 S domain protein 0YF83 Cluster_648765 V1199967 S Addiction module antitoxin, RelB DinJ family 11X3K Cluster_27887 V1199969 SCLAV_2282 M Peptidoglycan binding domain protein COG3409 Cluster_394740 V1199970 S NA 11WGF Cluster_350541 V1199971 TRML map04122 J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) COG0219 Cluster_387689 V1199972 NTH map03410 L endonuclease III COG0177 Cluster_227751 V1199974 AQPZ G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) COG0580 Cluster_32704 V1199975 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_21402 V1199976 L HELICc COG4581 Cluster_678502 V1199978 YHBY J Rna-binding protein COG1534 Cluster_27177 V1199979 RV2326C map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_427074 V1199980 S Membrane COG3601 Cluster_139771 V1199982 PHOH T Phoh family COG1702 Cluster_318408 V1199984 S Membrane 11NPN Cluster_54749 V1199985 HHOA map02020 O Peptidase s1 and s6 chymotrypsin hap COG0265 Cluster_81341 V1199987 SCLAV_4061 S Uncharacterised conserved protein (DUF2342) COG5282 Cluster_253987 V1199988 YLBL T Secreted protein COG3480 Cluster_85909 V1199989 S DivIVA domain repeat protein 11XZ2 Cluster_303652 V1199990 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_167668 V1199991 DUSB J Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_292638 V1199992 TRMB C Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_342515 V1199993 S abc transporter atp-binding protein COG4721 Cluster_133471 V1199994 map00561,map01100 M group 1 glycosyl transferase COG0438 Cluster_542935 V1199995 RV2923C O OsmC family COG1765 Cluster_440926 V1199996 WZB T protein tyrosine phosphatase COG0394 Cluster_281697 V1199997 RV2219 S integral membrane protein 0Z3WW Cluster_26367 V1199998 METE map00270,map00450,map01100,map01110,map01230 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) COG0620 Cluster_889 V1199999 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_9783 V1200000 GLNE O, T Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) COG1391 Cluster_391123 V1200002 S NA 0Y0MV Cluster_103418 V1200003 M polysaccharide biosynthesis protein COG2244 Cluster_3983 V1200004 UVRD2 map03420,map03430 L helicase COG0210 Cluster_207225 V1200006 RBSK map00030 G ribokinase COG0524 Cluster_166137 V1200007 M Sortase family COG3764 Cluster_55493 V1200008 M Cell wall anchor domain protein 11Q8J Cluster_39144 V1200011 YFMR S abc transporter COG0488 Cluster_12794 V1200012 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG1754 Cluster_277686 V1200013 I esterase COG0657 Cluster_656954 V1200014 S toxin-antitoxin system, antitoxin component, ribbon-helix-helix 11U5W Cluster_405353 V1200015 CLOSA_0730 V Hnh endonuclease COG1479 Cluster_199876 V1200016 L DNA methylase n-4 n-6 domain protein COG0863 Cluster_261656 V1200017 CFR9IM L DNA Methylase COG0863 Cluster_820506 V1200018 S NA 0Z3DG Cluster_309268 V1200019 S NA 0ZW0F Cluster_339538 V1200020 S NA 0XTII Cluster_656955 V1200021 S NA COG4694 Cluster_683049 V1200022 S NA 0ZXAM Cluster_177779 V1200023 S Inherit from COG: virion core protein (Lumpy skin disease COG4260 Cluster_385845 V1200024 S NA 0Y2P8 Cluster_839791 V1200026 MSRA S methionine sulfoxide reductase A 0YJ5R Cluster_695820 V1200027 MSRA S methionine sulfoxide reductase A 0YJ5R Cluster_421494 V1200028 S NA 0Y0MV Cluster_780925 V1200029 S NA 127RR Cluster_202923 V1200031 BL02849 S Baat aCyl-coa thioester hydrolase COG1073 Cluster_138231 V1200033 S Peptidoglycan-binding domain 1 protein 0ZWAS Cluster_315315 V1200034 PHNL3 V Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) COG1136 Cluster_166874 V1200035 SCLAV_2953 V (ABC) transporter COG0577 Cluster_251523 V1200036 S ABC transporter substrate-binding protein 0ZK3U Cluster_37487 V1200037 S TPR repeat-containing protein COG0457 Cluster_330473 V1200038 map00361,map00625,map01100,map01120 S had-superfamily hydrolase, subfamily ia, variant COG1011 Cluster_35044 V1200039 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_175325 V1200040 RLMB J RNA methyltransferase TrmH family group 3 COG0566 Cluster_194410 V1200042 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_73853 V1200043 map02010 S ABC transporter COG1123 Cluster_239869 V1200044 PDXS map00750 H Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) COG0214 Cluster_405354 V1200045 PDXT map00750 H Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) COG0311 Cluster_289966 V1200047 PFLA O Pyruvate formate-lyase COG1180 Cluster_389398 V1200049 I phosphoesterase PA-phosphatase related protein COG0671 Cluster_480320 V1200050 PTH J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) COG0193 Cluster_363 V1200051 S NA 0ZTYV Cluster_14077 V1200052 CAS3 L CRISPR-associated helicase, cas3 COG1203 Cluster_69602 V1200053 CASA L crispr-associated protein 0XPA1 Cluster_401763 V1200054 CASB S CRISPR system CASCADE complex protein CasB 0ZXJT Cluster_266974 V1200055 CAS5E L crispr-associated protein 11JEJ Cluster_375266 V1200056 CASE L crispr-associated protein 0XPHC Cluster_714848 V1200057 map00350,map00362,map00627,map00642,map00903,map01120 S acetyltransferase, (GNAT) family COG3981 Cluster_656956 V1200058 S NA 1228P Cluster_731335 V1200060 MUTT L mutator MutT protein COG0494 Cluster_51737 V1200061 S Uncharacterized conserved protein (DUF2075) 0XPB6 Cluster_828394 V1200062 S NA 11SAZ Cluster_648767 V1200063 S NA 11SAZ Cluster_322939 V1200064 V NA 0Y1U9 Cluster_751414 V1200065 S NA 0YK5G Cluster_51321 V1200066 M Inherit from NOG: Lpxtg-motif cell wall anchor domain protein 0Y6CS Cluster_785099 V1200070 S NA 1AQGC@spiNOG Cluster_97347 V1200071 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_116 V1200072 S NA 0YZ82 Cluster_387690 V1200073 TMK map00240,map01100 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) COG0125 Cluster_313729 V1200074 map03060,map03070 U sec-independent protein 0ZXQT Cluster_98429 V1200075 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_121382 V1200077 VEX1 V ABC transporter, permease COG0577 Cluster_27689 V1200078 S NA 11FZK Cluster_189874 V1200079 S NA 11K9E Cluster_51917 V1200080 P periplasmic solute binding protein COG0803 Cluster_26257 V1200081 map00550,map01100 M glycosyl transferase, family 51 COG0744 Cluster_196952 V1200082 DNAJ1 O DnaJ domain protein COG2214 Cluster_344094 V1200083 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_48315 V1200084 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_335023 V1200085 MOEB map00730,map01100,map04122 H uba thif-type nad fad binding protein COG0476 Cluster_318409 V1200086 THIO map00730 E glycine oxidase COG0665 Cluster_97348 V1200087 Y2366 V ABC transporter, permease COG0577 Cluster_17972 V1200090 S Lipase (class 3) 0ZJUJ Cluster_242518 V1200091 S NA 11IEF Cluster_347295 V1200092 NANE map00520 G Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) COG3010 Cluster_243864 V1200093 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_116987 V1200094 PHOR map02020 T Histidine kinase 0XNMH Cluster_101696 V1200096 P Chloride channel COG0038 Cluster_728037 V1200098 H thiF family COG0476 Cluster_224319 V1200100 S Endonuclease Exonuclease phosphatase 0XPGG Cluster_295423 V1200101 L resolvase COG1961 Cluster_29894 V1200103 S NA 0ZUUB Cluster_32705 V1200104 LKTB3 V ABC transporter, ATP-binding protein COG2274 Cluster_133472 V1200105 S radical SAM domain protein COG0641 Cluster_39145 V1200106 S NA 0ZSEH Cluster_133473 V1200107 S Inherit from COG: ATPase (AAA COG1373 Cluster_220799 V1200109 K Transcriptional regulator (XRE family 0ZJRR Cluster_342516 V1200111 map00361,map00625,map01100,map01120 S had-superfamily hydrolase, subfamily ia, variant COG1011 Cluster_230077 V1200112 NNRD G carbohydrate kinase, YjeF related protein COG0063 Cluster_230078 V1200113 RNHA map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0328 Cluster_352041 V1200114 RPIA map00030,map00710,map01100,map01110,map01120,map01230 G phosphoriboisomerase A COG0120 Cluster_504665 V1200115 U TraG family COG3505 Cluster_238596 V1200116 L Integrase core domain protein COG2801 Cluster_499727 V1200123 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_37950 V1200124 V permease 0YATZ Cluster_448979 V1200125 QUEF map00790,map01100 S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) COG0780 Cluster_628979 V1200126 S mobilization protein 11J0G Cluster_108174 V1200127 VIRE L Virulence-associated protein e COG5545 Cluster_176119 V1200128 L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) COG0582 Cluster_751415 V1200129 S NA 186YM@proNOG Cluster_523094 V1200130 S HTH_XRE 11ZMP Cluster_68557 V1200131 T Serine Threonine protein kinase COG0515 Cluster_21403 V1200132 L HELICc COG4581 Cluster_103992 V1200133 PYRC map00230,map00240,map01100,map01120 F dihydroorotase COG0044 Cluster_208342 V1200134 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate (By similarity) COG0167 Cluster_355375 V1200135 PYRE map00240,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_33387 V1200136 MALQ map00500,map01100 G 4-alpha-glucanotransferase COG1640 Cluster_363542 V1200137 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_656957 V1200138 MJLS_4465 S protein, conserved in bacteria COG1937 Cluster_162877 V1200139 map02010 V ABC-2 type transporter COG0842 Cluster_766074 V1200140 S NA 0YQAH Cluster_1769 V1200144 S NA 11NI8 Cluster_8335 V1200145 YLBB V abc transporter permease protein COG0577 Cluster_283099 V1200146 S haloacid dehalogenase-like hydrolase COG0561 Cluster_174508 V1200147 MVAD map00900,map01100,map01110 I diphosphomevalonate decarboxylase COG3407 Cluster_22436 V1200148 FNI map00900,map01100,map01110 C Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) COG1577 Cluster_348923 V1200151 map02010 P Cobalt transport protein COG0619 Cluster_70233 V1200152 S NA 0YK1E Cluster_324510 V1200153 S Phage replisome organizer 0ZW0Q Cluster_14743 V1200154 S Lipase (class 3) 0ZJUJ Cluster_259031 V1200155 L Dna topoisomerase COG0550 Cluster_135059 V1200157 L Integrase 0YTFQ Cluster_573130 V1200158 M peptidase, S41 COG0793 Cluster_272367 V1200159 TRPC map00400,map01100,map01110,map01230 E Indole-3-glycerol phosphate synthase COG0134 Cluster_789080 V1200160 S NA 125T8 Cluster_119886 V1200162 RMUC S Dna recombination protein COG1322 Cluster_174509 V1200164 S phage protein 0XQDU Cluster_699103 V1200165 S rRNA biogenesis protein Rrp5 0XUK3 Cluster_247733 V1200166 M hydrolase, family 25 COG3757 Cluster_84280 V1200168 PUTP E Sodium proline symporter COG0591 Cluster_192587 V1200170 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_428964 V1200171 G Alpha-1,2-mannosidase COG3537 Cluster_1757 V1200172 S NA 0YZ82 Cluster_259032 V1200173 S repeat protein 0ZY5G Cluster_540072 V1200175 NIKR K Transcriptional regulator (By similarity) COG0864 Cluster_305154 V1200176 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_306542 V1200177 YLME F alanine racemase domain protein COG0325 Cluster_171961 V1200178 GLUQ map00860,map00970,map01100,map01110 J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) COG0008 Cluster_335024 V1200179 GLPF G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) COG0580 Cluster_201872 V1200180 S DNA-binding protein COG3943 Cluster_708381 V1200181 S lysozyme 0YC6U Cluster_419693 V1200182 TRAO S conjugative transposon protein TraO 0YB3M Cluster_230079 V1200183 TRAN S Conjugative transposon TraN protein 0XNQ2 Cluster_569924 V1200184 PGN_0971 L Transposase, is4 family COG3039 Cluster_249036 V1200185 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_523095 V1200186 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_74481 V1200187 J NOL1/NOP2/sun family COG0144 Cluster_223143 V1200188 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_338096 V1200190 S RumE protein 0Z8VP Cluster_167669 V1200191 NAGA map00052,map00520,map01110 G GlcNAc 6-P deacetylase COG1820 Cluster_27178 V1200192 S NA 11FZK Cluster_154445 V1200193 S NA 11K9E Cluster_467171 V1200194 MRAZ S Cell division protein mraZ COG2001 Cluster_90908 V1200195 ABFD map00350,map00650,map00720,map01120 Q 4-hydroxyphenylacetate COG2368 Cluster_303653 V1200198 SUSC P outer membrane protein SusC 0XNNV Cluster_73854 V1200199 S ragb susd domaiN-containing protein 0XP53 Cluster_442942 V1200203 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_242519 V1200205 S DNA primase COG3378 Cluster_53510 V1200207 V N-6 DNA Methylase COG0286 Cluster_434859 V1200208 V restriction 11FSE Cluster_153645 V1200210 GLF M udp-galactopyranose mutase COG0562 Cluster_48316 V1200211 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_128178 V1200212 RSGA G May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) COG1162 Cluster_705254 V1200214 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_569925 V1200215 L Transposase 11M0T Cluster_340990 V1200216 C Nitroreductase family COG0778 Cluster_122146 V1200217 S Inherit from COG: ATPase (AAA COG1373 Cluster_189010 V1200218 L TatD-related deoxyribonuclease COG0084 Cluster_352042 V1200219 S NA 0YM1X Cluster_105800 V1200221 S NA 0Z34Z Cluster_89969 V1200222 L Dna topoisomerase COG0550 Cluster_365280 V1200223 SERB map00260,map00680,map01100,map01120,map01230 E phosphoserine phosphatase COG0560 Cluster_112759 V1200226 S NA 11GMQ Cluster_542936 V1200228 S NA COG4694 Cluster_357063 V1200229 S NA COG4694 Cluster_194411 V1200230 S NA COG4694 Cluster_234884 V1200232 map02010 P ABC transporter (Permease) COG0601 Cluster_628980 V1200233 S NA 11EJP Cluster_11634 V1200234 SCLAV_2624 S NA 0YQAJ Cluster_161199 V1200236 MUTT1 L NUDIX hydrolase COG0494 Cluster_30952 V1200237 PPK map00190,map03018 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) COG0855 Cluster_40236 V1200238 SELB map00450,map00970 J Selenocysteine-specific translation elongation factor COG3276 Cluster_737890 V1200239 RLMB J RNA methyltransferase TrmH family group 3 COG0566 Cluster_40859 V1200240 PLC map00562 S Phosphatidylinositol-specific phospholipase C 0ZKFY Cluster_744612 V1200241 XC_0137 L transposase COG3039 Cluster_247734 V1200242 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_800712 V1200243 GLPA map00564,map00730 C fad dependent oxidoreductase COG0579 Cluster_186469 V1200244 CSE4 L Crispr-associated protein, cse4 family 0Y6PV Cluster_336560 V1200245 YAAA L UPF0246 protein COG3022 Cluster_15157 V1200247 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_87256 V1200249 S ATPase (AAA COG1373 Cluster_160369 V1200250 S Phage-Associated Protein COG3600 Cluster_338097 V1200251 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_365281 V1200252 L DNA alkylation repair enzyme COG4912 Cluster_389399 V1200256 SCLAV_3539 G phosphoglycerate mutase COG0406 Cluster_77123 V1200257 S NA 12D1P Cluster_6006 V1200258 S NA 0YG6V Cluster_309269 V1200260 NFRA map00051,map00190,map00363,map00591,map00625,map00633,map00650,map01100,map01120 C nitroreductase COG0778 Cluster_89052 V1200261 L helicase COG4646 Cluster_859275 V1200262 L DNA binding protein, excisionase family 0YKT7 Cluster_812958 V1200264 V restriction endonuclease 0XQN3 Cluster_13290 V1200265 CAS3 L CRISPR-associated helicase, cas3 COG1203 Cluster_309270 V1200266 LPXA map00540,map01100 M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) COG1043 Cluster_61806 V1200268 S Inherit from NOG: LPXTG-motif cell wall anchor domain protein 0YEBJ Cluster_302206 V1200269 COBQ S Glutamine amidotransferase COG3442 Cluster_563638 V1200270 S Uncharacterised protein family (UPF0233) 0ZZV4 Cluster_391124 V1200271 S Conjugative transposon protein TraI 0YE08 Cluster_201873 V1200272 TRAJ S conjugative transposon 0XP5P Cluster_202925 V1200273 T FHA Domain-Containing protein 0ZXYF Cluster_828395 V1200274 S kila-n, DNA-binding domain 0XPNQ Cluster_72477 V1200275 U TraG family COG3505 Cluster_22276 V1200277 RLML L Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) COG1092 Cluster_97349 V1200278 map03440 K Inherit from firmNOG: Transcriptional regulator COG2865 Cluster_473571 V1200279 MDLA V ABC transporter, ATP-binding protein COG1132 Cluster_238597 V1200282 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_48762 V1200283 RECQ2 map03018 L ATP-dependent DNA helicase RecQ COG0514 Cluster_35171 V1200285 map02020,map02030 S Methyl-accepting chemotaxis protein (MCP) signalling domain COG0840 Cluster_239870 V1200286 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate (By similarity) COG0167 Cluster_250300 V1200287 S P-loop domain protein 0XQDB Cluster_271041 V1200288 PANC map00410,map00770,map01100,map01110 H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) COG0414 Cluster_603107 V1200289 S NA 122IS Cluster_305155 V1200290 K AntA/AntB antirepressor COG3645 Cluster_347296 V1200291 S Plasmid pRiA4b ORF-3 family protein 11TVE Cluster_531581 V1200292 S Single-strand binding protein family 0ZH3K Cluster_8818 V1200293 M Inherit from NOG: Polymorphic outer membrane protein 11KKP Cluster_90909 V1200294 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_9027 V1200295 U, W Inherit from COG: domain protein COG5295 Cluster_103993 V1200296 PBUG S Xanthine uracil vitamin C permease COG2252 Cluster_458829 V1200297 RPLJ map03010 J 50s ribosomal protein L10 COG0244 Cluster_417926 V1200298 PNUC H Nicotinamide Mononucleotide Transporter COG3201 Cluster_378812 V1200299 THIN map00730,map01100 H thiamine COG1564 Cluster_239871 V1200300 S kila-n, DNA-binding domain 0XPNQ Cluster_68558 V1200301 L DNA methylase COG2189 Cluster_259033 V1200302 CAS2 L CRISPR-associated protein cas2 11VHR Cluster_59069 V1200304 S NA 11QZ9 Cluster_318410 V1200309 DNAJ3 O DnaJ domain protein COG2214 Cluster_221964 V1200310 S Inherit from NOG: surface antigen 0XQ7Y Cluster_130328 V1200311 RPSA map00900,map01100,map01110,map03010 J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) COG0539 Cluster_21076 V1200313 L dEAD DEAH box helicase COG1204 Cluster_104588 V1200315 GLMU map00520,map01100,map01110 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) COG1207 Cluster_515101 V1200317 map00630,map00680,map01100,map01120 C molybdopterin oxidoreductase Fe4S4 11M2S Cluster_14078 V1200318 S NA 0ZT9Z Cluster_15363 V1200319 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_520335 V1200321 ATPG map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) COG0224 Cluster_12795 V1200324 U, W Pfam:YadA COG5295 Cluster_13493 V1200325 map00511,map00600,map04142 G BNR Asp-box repeat protein COG4409 Cluster_228931 V1200326 I Diacylglycerol kinase COG1597 Cluster_708382 V1200328 GLNR K transcriptional regulator COG0745 Cluster_232414 V1200329 MOBA H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) COG1763 Cluster_202926 V1200330 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_37488 V1200332 GLTS E Sodium Glutamate Symporter COG0786 Cluster_266976 V1200333 MRP D ATP-binding protein COG0489 Cluster_812959 V1200334 K Transcriptional regulator COG1476 Cluster_283100 V1200336 DPRA L DNA protecting protein DprA COG0758 Cluster_440927 V1200337 S Vanz family 0XV9Q Cluster_144210 V1200339 BL01661 map05146 O proteinase inhibitor I4 serpin COG4826 Cluster_66855 V1200340 G Aamy_C COG1523 Cluster_287313 V1200341 M hydrolase, family 25 COG3757 Cluster_18204 V1200342 RES_1 V type IIi COG3421 Cluster_365282 V1200343 LOLD map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_18046 V1200344 CLPC O ATP-dependent Clp protease, ATP-binding subunit ClpC COG0542 Cluster_257705 V1200345 S NA 0Z2K0 Cluster_385846 V1200346 map00730,map01100 H Thiamine monophosphate synthase 11FJG Cluster_50760 V1200347 HSDS V Restriction modification system DNA (Specificity COG0732 Cluster_223144 V1200348 S NA 0YFDR Cluster_300811 V1200350 TATD L Hydrolase, tatD family COG0084 Cluster_196953 V1200351 L type iii restriction protein res subunit COG4951 Cluster_728038 V1200352 S NA 0ZDIF Cluster_124087 V1200353 VEX1 V ABC transporter, permease COG0577 Cluster_425139 V1200355 PTH J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) COG0193 Cluster_84281 V1200356 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_502274 V1200357 S Domain of unknown function (DUF1896) 11Y7P Cluster_769860 V1200359 VSR L DNA mismatch endonuclease (vsr) COG3727 Cluster_43131 V1200363 S domain protein 0YF83 Cluster_871625 V1200364 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_44832 V1200366 RPSA map00900,map01100,map01110,map03010 J Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) COG0761 Cluster_175326 V1200367 S phage protein 0XQDU Cluster_419694 V1200368 S Phage-associated protein 11FS5 Cluster_255200 V1200370 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_179494 V1200373 UGPC map02010 G (ABC) transporter COG3839 Cluster_157803 V1200374 NIFS map00450,map00730,map01100,map04122 E cysteine desulfurase family protein COG0520 Cluster_310710 V1200377 S Inherit from COG: Virulence-associated protein e COG4983 Cluster_475696 V1200379 S C_GCAxxG_C_C family 11W24 Cluster_24360 V1200381 U, W Pfam:YadA COG5295 Cluster_430931 V1200382 HSDM V Type I restriction-modification system, M subunit COG0286 Cluster_180316 V1200383 HSDS V type I restriction modification DNA specificity domain COG0732 Cluster_321375 V1200384 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_61807 V1200386 U, W domain protein COG5295 Cluster_152039 V1200389 S domain protein 0XS27 Cluster_96283 V1200391 SLGD_00086 S Ser Thr phosphatase family protein COG1409 Cluster_27778 V1200392 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_182071 V1200396 UXUA map00040,map01100 G Catalyzes the dehydration of D-mannonate (By similarity) COG1312 Cluster_436909 V1200397 RPLE map03010 J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COG0094 Cluster_211599 V1200406 S NA 122HI Cluster_480322 V1200408 CPHY_1803 L transposase 0XQMH Cluster_789081 V1200410 S NA 0YXS4 Cluster_56495 V1200411 ARGS map00970 J arginyL-tRNA synthetase COG0018 Cluster_31412 V1200412 S NA 0YZ82 Cluster_243865 V1200413 ATPA map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_145707 V1200414 L site-specific recombinase, phage integrase family 0ZF8H Cluster_275047 V1200418 S (LipO)protein 0XSYT Cluster_766075 V1200419 ATPC map00190,map00195,map01100 S Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) 0ZRQB Cluster_80964 V1200420 S (LipO)protein 0XSYT Cluster_329074 V1200421 FECD map02010 P ABC superfamily ATP binding cassette transporter membrane protein COG0609 Cluster_625260 V1200422 TRAF2 S conjugative transposon protein TraF 0YJGM Cluster_714850 V1200423 DEOA map00240,map00983,map01100,map05219 F The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) COG0213 Cluster_377031 V1200424 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_275048 V1200427 STRIC_0432 L Transposase (IS4 family 11HCS Cluster_291275 V1200428 SUFC O feS assembly ATPase SufC COG0396 Cluster_428965 V1200430 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_277687 V1200432 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_285911 V1200434 M hydrolase, family 25 COG3757 Cluster_141256 V1200435 PORAS_0418 L reverse transcriptase COG3344 Cluster_205033 V1200436 K transcriptional regulator 11UUP Cluster_452903 V1200438 map00860,map01100 H Cob-I-yrinic acid a,c-diamide adenosyltransferase COG2109 Cluster_484955 V1200439 SP_0119 L Nudix family COG0494 Cluster_245136 V1200441 YDJZ S SNARE associated Golgi protein-related protein COG0398 Cluster_871626 V1200442 PRFC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) COG4108 Cluster_528795 V1200445 S Protein of unknown function (DUF3408) 11QAR Cluster_210466 V1200446 S NA 0XTEF Cluster_336561 V1200450 TRPF map00400,map01100,map01110,map01230 E N-(5'-phosphoribosyl)anthranilate isomerase COG0135 Cluster_423356 V1200451 CASB S CRISPR system CASCADE complex protein CasB 0ZXJT Cluster_338098 V1200452 map03070 S NA 122A7 Cluster_224320 V1200454 S Pfam:YadA 0YNSE Cluster_326016 V1200455 AMPG2 E, G, P Beta-lactamase induction signal transducer COG0477 Cluster_277688 V1200456 UDK map00240,map00983,map01100 F uridine kinase COG0572 Cluster_49965 V1200460 U, W Domain-Containing protein COG5295 Cluster_515102 V1200461 S NA 0ZQAM Cluster_96802 V1200463 S NA 0Y9G8 Cluster_531582 V1200468 HSP20 map04141 O Heat shock protein COG0071 Cluster_835986 V1200470 BL00603 S Protein of unknown function (DUF2089) 125WH Cluster_442943 V1200471 LUXS map00270,map05111 T Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) COG1854 Cluster_724786 V1200473 V ABC transporter, permease protein 0XP9H Cluster_50357 V1200475 U, W surface protein COG5295 Cluster_56763 V1200477 NIFJ map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map00910,map01100,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_122824 V1200478 V restriction endonuclease 0Z1AJ Cluster_385847 V1200480 S NA 0XQ5H Cluster_621470 V1200484 WZB T protein tyrosine phosphatase COG0394 Cluster_116988 V1200487 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_454927 V1200492 K RNA Polymerase COG1595 Cluster_792875 V1200493 S toxin-antitoxin system, antitoxin component, Xre family 0Y0YN Cluster_192588 V1200496 S ApbE family 11H27 Cluster_114873 V1200497 XC_0137 L transposase COG3039 Cluster_276382 V1200502 S NA 12BYI Cluster_71512 V1200503 M Glycosyl hydrolases family 25 COG5263 Cluster_399978 V1200505 S NA 0ZHU9 Cluster_62624 V1200507 map02010 P ABC transporter COG1131 Cluster_357064 V1200508 S membrAne 120XT Cluster_674043 V1200509 LICB map02060 G PTS System COG1440 Cluster_94161 V1200511 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_174510 V1200512 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_202927 V1200513 MBL D Rod shape-determining protein mreb COG1077 Cluster_154446 V1200514 PSEH map00330,map00350,map00362,map00520,map00627,map00642,map00903,map01100,map01120 J -acetyltransferase COG1670 Cluster_724787 V1200518 S Abortive infection protein AbiGII 0XQHH Cluster_636812 V1200519 S NA 0YVCN Cluster_137467 V1200520 S conjugative transposon 0YI63 Cluster_636813 V1200521 RLUD J Pseudouridine synthase COG0564 Cluster_434860 V1200523 S NA 125RT Cluster_436910 V1200524 PNCA map00760,map01100 Q isochorismatase COG1335 Cluster_260333 V1200525 L Site-specific recombinase COG1961 Cluster_288671 V1200528 PYRF map00240,map00983,map01100 F orotidine 5''-phosphate decarboxylase COG0284 Cluster_576353 V1200529 S NA 11HB4 Cluster_157804 V1200532 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_75466 V1200536 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_124740 V1200538 YEEA V methylase COG1002 Cluster_303654 V1200539 O ADP-ribosylglycohydrolase COG1397 Cluster_835989 V1200540 S NA 127RR Cluster_79152 V1200542 U, W Inherit from COG: domain protein COG5295 Cluster_316845 V1200543 V type I restriction modification DNA specificity domain COG0732 Cluster_294017 V1200544 HSDM V Type I restriction-modification system, M subunit COG0286 Cluster_202928 V1200545 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_454928 V1200551 S NA 101EI Cluster_900338 V1200552 G pfkb domain protein COG0524 Cluster_847826 V1200553 XERD L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_148815 V1200554 DXR map00900,map01100,map01110 I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) COG0743 Cluster_592553 V1200555 CCEL_3034 S NA 0XYGI Cluster_773498 V1200556 LYSM S Lysm domain protein 12BED Cluster_446963 V1200558 OADA map00020,map00330,map00620,map00720,map01100,map01120,map01230 C Oxaloacetate decarboxylase COG5016 Cluster_89053 V1200560 U, W Inherit from COG: domain protein 121KM Cluster_316846 V1200561 M Cell wall anchor domain protein 11Q8J Cluster_144961 V1200563 map00230,map01100,map01110 F AICARFT/IMPCHase bienzyme COG0138 Cluster_832066 V1200564 S Recombinase 0Y2JQ Cluster_592554 V1200565 L Site-specific recombinase COG1961 Cluster_494567 V1200566 TEX K domain protein COG2183 Cluster_94162 V1200571 S transglutaminase domain-containing protein 0XQP2 Cluster_199877 V1200572 S NA 0ZUV9 Cluster_640838 V1200575 S NA 127RR Cluster_683052 V1200576 S Addiction module antitoxin, RelB DinJ family 0XUTM Cluster_557624 V1200577 K Transcriptional regulator, TetR family 128VI Cluster_166138 V1200581 map02010 P Periplasmic binding protein COG0614 Cluster_446964 V1200582 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_168519 V1200583 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) COG0167 Cluster_566835 V1200587 UDP map00230 S phosphorylase 11F11 Cluster_116989 V1200588 U, W surface protein COG5295 Cluster_566836 V1200589 RPSH map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) COG0096 Cluster_157805 V1200592 S NA 0ZYTH Cluster_121383 V1200593 map02010 G solute-binding protein COG1653 Cluster_279050 V1200595 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_534356 V1200597 S NA 11SH1 Cluster_551854 V1200599 PURM map00230,map01100,map01110 F phosphoribosylaminoimidazole synthetase COG0150 Cluster_116279 V1200600 S NA 0XSI9 Cluster_237279 V1200603 M glycosyltransferase group 2 family protein COG0463 Cluster_305156 V1200605 TNP7109-5 L transposase COG2801 Cluster_178614 V1200606 M ompA MotB domain-containing protein COG2885 Cluster_360400 V1200609 LYSA map00300,map01100,map01110,map01120,map01230 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) COG0019 Cluster_122147 V1200610 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_299451 V1200613 V ABC transporter, permease protein 0XP9H Cluster_125402 V1200614 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_380531 V1200615 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_366986 V1200618 S Endonuclease Exonuclease phosphatase 0XPGG Cluster_718115 V1200619 S Protein of unknown function (DUF3298) 0Y1DT Cluster_721427 V1200620 PURA map00230,map00250,map01100 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis COG0104 Cluster_133474 V1200622 U, W Pfam:YadA COG5295 Cluster_245137 V1200623 S periplasmic component of amino acid ABC-type transporter signal transduction system 11IU5 Cluster_867722 V1200624 CRCB D Protein CrcB homolog COG0239 Cluster_348924 V1200627 S Domain of unknown function DUF20 COG0628 Cluster_260334 V1200628 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_139773 V1200630 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_214992 V1200631 TOPB map03018 L DNA topoisomerase COG0550 Cluster_268378 V1200633 PSTS map02010,map02020,map05152 P phosphate COG0226 Cluster_143462 V1200634 L helicase COG4646 Cluster_327575 V1200635 MEND map00130,map01100,map01110 H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) COG1165 Cluster_576354 V1200638 map02020,map02030 T Response regulator receiver domain COG0784 Cluster_236081 V1200639 PEPR map00330 E Releases the N-terminal proline from various substrates (By similarity) 0ZVHU Cluster_465086 V1200640 YIGL S Hydrolase COG0561 Cluster_625261 V1200643 TRAF2 S conjugative transposon protein TraF 0YJGM Cluster_196954 V1200644 PURB map00230,map00250,map01100,map01110 F Adenylosuccinate lyase COG0015 Cluster_196139 V1200646 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_153646 V1200647 ARCA map00330,map01100,map01110 E Arginine dihydrolase COG2235 Cluster_847827 V1200648 S NA 11VCX Cluster_231248 V1200649 S NA 11VIT Cluster_257706 V1200651 S NA 100FP Cluster_705257 V1200652 S NA 0ZHU9 Cluster_223145 V1200654 S NA 0YQTT Cluster_408799 V1200656 NTH map03410 L endonuclease III COG0177 Cluster_405355 V1200659 HSDR V Type I Restriction COG0610 Cluster_170312 V1200660 M Catalyzes the conversion of a range of fructosamine 6- phosphates to glucose 6-phosphate and a free amino acid (By similarity) COG2222 Cluster_172869 V1200661 U, W Domain-Containing protein COG5295 Cluster_363543 V1200666 GSIA map02010 S (ABC) transporter COG1123 Cluster_360401 V1200671 REX K Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) COG2344 Cluster_401764 V1200672 DEOD map00230,map00240,map00270,map00760,map01100,map01110 F purine nucleoside phosphorylase DeoD-type COG0813 Cluster_674045 V1200674 S NA 0YBIC Cluster_208343 V1200678 MENC map00130,map01100,map01110 M mandelate racemase muconate lactonizing COG4948 Cluster_396536 V1200679 LEXA K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) COG1974 Cluster_188167 V1200682 S SusD family 0XPTK Cluster_202929 V1200686 HOLA map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii, delta' subunit COG1466 Cluster_189011 V1200687 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_692024 V1200689 NANM S Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) COG3055 Cluster_193473 V1200692 S NA 12D73 Cluster_196140 V1200695 M Membrane COG4775 Cluster_196141 V1200696 NANH map00511,map00600,map04142 G BNR Asp-box repeat protein COG4409 Cluster_695821 V1200697 S NA 0ZHU9 Cluster_596021 V1200699 E peptidase, M24 COG0006 Cluster_702196 V1200703 T PP2Cc 0YSXA Cluster_277689 V1200706 E, P Permease protein COG1173 Cluster_296765 V1200707 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_665361 V1200708 S NA 0ZHU9 Cluster_674046 V1200711 DCM map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_360402 V1200712 HFLC O SPFH domain, Band 7 family protein COG0330 Cluster_241149 V1200716 S NA 11NI8 Cluster_284466 V1200717 MANA map00051,map00520,map01100,map01110 G mannose-6-phosphate isomerase COG1482 Cluster_219611 V1200719 FIXA V ABC transporter, ATP-binding protein COG1131 Cluster_226619 V1200722 S Lipase (class 3) 0ZJUJ Cluster_432946 V1200725 E peptidase 0XRNU Cluster_734591 V1200726 J Glutamine amidotransferase COG2355 Cluster_419695 V1200732 S NA 11RX2 Cluster_859278 V1200738 S Membrane 11VWS Cluster_243866 V1200739 HCAN_0220 S Pfam:DUF395 0XPA5 Cluster_256422 V1200741 S NA 123I1 Cluster_302207 V1200743 P ABC transporter (Permease COG0600 Cluster_648769 V1200744 TFOX K TfoX, N-terminal domain protein COG3070 Cluster_744614 V1200745 S NA 0ZHU9 Cluster_687441 V1200746 S NA 17D58@proNOG Cluster_777238 V1200748 PILT N, U twitching motility protein COG2805 Cluster_391125 V1200751 CLOSA_1745 L transposase COG2963 Cluster_335025 V1200758 M hydrolase, family 25 COG3757 Cluster_566837 V1200763 HSLO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) COG1281 Cluster_268379 V1200764 RECQ map03018 L ATP-dependent DNA helicase RecQ COG0514 Cluster_484956 V1200767 FOLK map00790,map01100 H 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase COG0801 Cluster_648770 V1200769 ALAT map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aspartate transaminase COG0436 Cluster_360403 V1200771 K TRANSCRIPTIONal COG3711 Cluster_734592 V1200772 S NA 11KIH Cluster_277690 V1200775 S NA 0Y00S Cluster_423357 V1200776 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_275049 V1200777 ATPA map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_294018 V1200778 HK01 T Histidine kinase COG0642 Cluster_280354 V1200780 I Acyl-ACP thioesterase COG3884 Cluster_384088 V1200782 CYSK map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_284467 V1200784 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_548953 V1200787 O Inherit from COG: glutaredoxin-related protein COG4545 Cluster_603109 V1200789 S NA 0ZUV1 Cluster_460882 V1200791 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_298168 V1200798 U, W Pfam:YadA COG5295 Cluster_412478 V1200799 MDMC map00340,map00350,map00360,map00624,map00940,map00941,map00945,map01100,map01110,map01120 S O-methyltransferase COG4122 Cluster_463001 V1200800 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_758393 V1200802 S NA 0ZJP4 Cluster_494568 V1200803 OCAR_6158 L Terminase, large subunit COG4626 Cluster_721428 V1200804 map00520,map01110 G hydrolase family COG1472 Cluster_338099 V1200805 FRUA map00051,map01100,map02060 G PTS System COG1762 Cluster_467172 V1200806 L site-specific recombinase, phage integrase family 0ZF8H Cluster_859279 V1200807 YCBB S ErfK YbiS YcfS YnhG family protein COG2989 Cluster_851581 V1200808 V Type III restriction enzyme, res subunit 0ZVHQ Cluster_699104 V1200809 S VRR-NUC domain protein 122HE Cluster_318411 V1200812 S Inherit from COG: ATPase (AAA COG1373 Cluster_839797 V1200817 K Cupin domain COG1396 Cluster_347297 V1200818 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_360404 V1200824 ADK map00230,map00240,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_327576 V1200826 TRMI J tRNA (Adenine-N1-)-methyltransferase COG2519 Cluster_405356 V1200828 HMUY S NA 0XZUM Cluster_912988 V1200830 S NA 0ZHU9 Cluster_741344 V1200833 S NA 0ZHU9 Cluster_333523 V1200834 P TonB-dependent receptor 1AIHM@sphNOG Cluster_523096 V1200835 YCBB S ErfK YbiS YcfS YnhG family protein COG2989 Cluster_458831 V1200836 LEUD map00290,map00300,map00660,map01100,map01110,map01210,map01230 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) COG0066 Cluster_494569 V1200838 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_336562 V1200839 ACRA6 V efflux transporter, rnd family, mfp subunit COG0845 Cluster_408800 V1200840 HEMN map00860,map01100,map01110 C coproporphyrinogen COG0635 Cluster_579443 V1200845 RPLS map03010 J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) COG0335 Cluster_347298 V1200848 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_614020 V1200850 INSI L transposase COG2826 Cluster_702198 V1200852 S NA 0ZHU9 Cluster_352043 V1200856 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_352044 V1200857 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_507236 V1200858 NAGC map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 K ROK family COG1940 Cluster_353711 V1200859 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_573131 V1200861 AMD E amidohydrolase COG1473 Cluster_484957 V1200862 UBIE map00130,map01100,map01110 H Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) COG2226 Cluster_357065 V1200863 S Membrane 0XRRH Cluster_357066 V1200864 S relaxase mobilization nuclease domain protein 0XNXG Cluster_839799 V1200868 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_674047 V1200871 P TonB-dependent receptor Plug 0XNPQ Cluster_628982 V1200874 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_366987 V1200879 HEMZ map00860,map01100,map01110 C coproporphyrinogen COG0635 Cluster_366988 V1200880 OPPD E, P ABC transporter COG0444 Cluster_384089 V1200881 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_368607 V1200882 L Integrase COG0582 Cluster_656959 V1200883 S phospholipid-binding protein COG1881 Cluster_430932 V1200886 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0847 Cluster_557625 V1200887 CDD map00240,map00983,map01100,map05219 F cytidine deaminase COG0295 Cluster_370319 V1200888 S Abortive infection protein AbiGI 11WH3 Cluster_440928 V1200891 L phage plasmid primase, p4 family COG3378 Cluster_373550 V1200892 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E amino acid aminotransferase COG0115 Cluster_859280 V1200901 S HTH domain protein 11Z0Z Cluster_891934 V1200903 S NA 0ZHU9 Cluster_382300 V1200906 M NLP P60 protein COG2247 Cluster_380532 V1200908 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_452904 V1200911 I diacylglycerol kinase, catalytic COG1597 Cluster_387692 V1200914 INFC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) COG0290 Cluster_754850 V1200916 RESD map02020 T Response regulator receiver domain protein COG0745 Cluster_389400 V1200918 AROB map00400,map01100,map01110,map01230 E 3-dehydroquinate synthase COG0703 Cluster_391126 V1200924 S NA 0Y83C Cluster_579444 V1200925 TYPA T gtp-binding protein typa COG1217 Cluster_427076 V1200926 U Biopolymer transport protein exbD tolR 11JQD Cluster_398261 V1200929 CLPP map04112 O ATP-dependent Clp protease, proteolytic subunit COG0740 Cluster_438960 V1200931 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_820511 V1200932 S NA 0ZHU9 Cluster_515103 V1200936 RBSA S ABC transporter COG3845 Cluster_531584 V1200938 L transposase COG3666 Cluster_401766 V1200942 map00051 M group 2 family COG0463 Cluster_489588 V1200944 K transcriptional regulator AsnC family COG1522 Cluster_471454 V1200948 CELAL_0017 S NA 11TT6 Cluster_407046 V1200953 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_408801 V1200954 FBA map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01230 G fructose-bisphosphate aldolase COG0191 Cluster_410659 V1200956 map00500,map01100 N Alpha-L-fucosidase 0XPGV Cluster_410660 V1200958 S phosphate 0XP49 Cluster_678506 V1200960 RPSJ map03010 J Involved in the binding of tRNA to the ribosomes (By similarity) COG0051 Cluster_412481 V1200961 T response regulator (Receiver 11EZS Cluster_414337 V1200963 S NA 0YCCW Cluster_414338 V1200964 map00330,map01110,map01230 E Ornithine Cyclodeaminase COG2423 Cluster_450956 V1200966 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_741346 V1200968 PGSA2 map00564,map01100 I Cdp-alcohol phosphatidyltransferase COG0558 Cluster_557626 V1200970 APT map00230,map01100 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) COG0503 Cluster_417927 V1200971 S NA 11HVF Cluster_419697 V1200975 S domain protein 0XNZW Cluster_751418 V1200977 COXC map00190,map00910,map01100 C Cytochrome C Oxidase, Subunit III COG1845 Cluster_421495 V1200981 GLNN map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG3968 Cluster_773502 V1200984 P TonB-dependent receptor Plug COG4771 Cluster_425140 V1200986 DPNA L helicase COG4646 Cluster_499728 V1200992 S Phage terminase small subunit 11F23 Cluster_828402 V1200996 L site-specific recombinase, phage integrase family 0ZF8H Cluster_610388 V1200997 L Integrase 0YTFQ Cluster_432947 V1201003 HSDR V Type I Restriction COG0610 Cluster_434863 V1201007 BMUL_0955 map00030,map01100,map01110,map01120 G 6-phosphogluconolactonase (EC 3.1.1.31) COG2706 Cluster_467173 V1201009 U, W Pfam:Hep_Hag COG5295 Cluster_452905 V1201010 S Adenylate cyclase COG2954 Cluster_804963 V1201011 NTH map03410 L endonuclease III COG0177 Cluster_548954 V1201013 S Acyltransferase family 0YAKZ Cluster_452906 V1201029 U, W Pfam:YadA COG5295 Cluster_452907 V1201033 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_891936 V1201039 RNHA map03030 S Ribonuclease COG3341 Cluster_454930 V1201044 M Cell wall anchor domain protein 11Q8J Cluster_456868 V1201046 MRAZ S Cell division protein mraZ COG2001 Cluster_509834 V1201048 U TraG family COG3505 Cluster_458832 V1201050 S NA 11NI8 Cluster_477902 V1201051 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_528797 V1201058 S Uncharacterised protein family (UPF0233) 0ZZV4 Cluster_582681 V1201060 MTAD F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) COG0402 Cluster_465088 V1201063 MURF map00300,map00550,map01100 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) COG0770 Cluster_465089 V1201067 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_465090 V1201068 S NA 0XTWQ Cluster_563641 V1201074 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_469321 V1201076 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_471455 V1201077 PRIA map03440 L Primosomal protein n' COG1198 Cluster_520337 V1201084 GATB map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 Cluster_537273 V1201088 YHCG V abc transporter atp-binding protein COG1131 Cluster_473572 V1201089 map02010 P ABC transporter COG1121 Cluster_542938 V1201091 GLTT C Proton sodium-glutamate symport protein GltT COG1301 Cluster_528798 V1201093 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_475697 V1201095 I Diacylglycerol kinase COG1597 Cluster_475698 V1201096 C FMN-binding domain protein COG3976 Cluster_582682 V1201103 map00010 G Glycosyl hydrolase family 1 COG2723 Cluster_724791 V1201111 G polysaccharide deacetylase COG0726 Cluster_484958 V1201113 E amino acid COG0531 Cluster_758394 V1201115 L DNA topoisomerase COG0550 Cluster_489590 V1201118 MRAY map00550,map01100 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) COG0472 Cluster_596022 V1201119 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_494570 V1201121 P tonB-dependent receptor plug 0YT3X Cluster_494571 V1201124 RMUC S Dna recombination protein COG1322 Cluster_497078 V1201130 L RecA-family ATPase COG3598 Cluster_534358 V1201133 YPDE map00500,map01100 E Peptidase m42 family protein COG1363 Cluster_499729 V1201134 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_504666 V1201141 S Alpha beta hydrolase COG0596 Cluster_504667 V1201143 PPNK map00760,map01100 G Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) COG0061 Cluster_507237 V1201145 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_606724 V1201146 FLHB2 S flagellar COG2257 Cluster_617807 V1201147 L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) COG0582 Cluster_512411 V1201152 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_512412 V1201153 ISDF map02010 P ABC transporter, permease COG0609 Cluster_515104 V1201157 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_515105 V1201158 ACD map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I Acyl-coa dehydrogenase COG1960 Cluster_515106 V1201159 QUEE map00790,map01100 H Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) COG0602 Cluster_515107 V1201160 D Conjugative transposon protein TraA 0Y9K3 Cluster_517797 V1201163 ELI_1297 O phage portal protein HK97 family COG4695 Cluster_545892 V1201164 PHUW E Iron-regulated protein COG3016 Cluster_517798 V1201166 S NA 0ZTYV Cluster_520338 V1201168 P tonB-dependent Receptor 0XQ03 Cluster_523097 V1201172 map02010 S transporter, permease COG4587 Cluster_523098 V1201178 V HpaII restriction endonuclease 11A91 Cluster_747985 V1201183 S Transglycosylase associated protein 12314 Cluster_526030 V1201185 S Endonuclease Exonuclease phosphatase 0ZJ9Y Cluster_851588 V1201187 map00052,map00500,map01100 G F5 8 type C domain protein COG1501 Cluster_531585 V1201197 S Pfam:YadA 0ZHSU Cluster_718119 V1201198 SECG map03060,map03070 U Preprotein translocase SecG subunit 121MY Cluster_542939 V1201217 L DNA polymerase 0XRUF Cluster_542940 V1201219 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_875764 V1201220 RLMH S Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) COG1576 Cluster_545893 V1201221 V ATPase associated with various cellular activities aaa_5 COG1401 Cluster_762100 V1201222 S NA 0ZHU9 Cluster_545894 V1201224 S helicase COG3972 Cluster_592555 V1201226 CYSN map00230,map00450,map00920,map01100,map01120 P May be the GTPase, regulating ATP sulfurylase activity (By similarity) COG2895 Cluster_548955 V1201227 MT2607 map00330,map00480,map01100,map01110 E decarboxylase COG1982 Cluster_912991 V1201230 G ROK family COG1940 Cluster_582683 V1201233 S Single-stranded nucleic acid binding R3H domain-containing protein COG1847 Cluster_665363 V1201238 SPOVG M Could be involved in septation (By similarity) COG2088 Cluster_554709 V1201243 map00051,map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 G Glycosyl hydrolase family 20 COG3525 Cluster_812966 V1201244 S NA 0ZHU9 Cluster_589189 V1201253 MURE map00300,map00550,map01100 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_560699 V1201254 S NA 0YG6V Cluster_711468 V1201258 O AAA domain (Cdc48 subfamily) COG0464 Cluster_563643 V1201259 S Relaxase mobilization nuclease 0Y9PG Cluster_563644 V1201260 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_563645 V1201261 HSPR K merR family transcriptional Regulator COG0789 Cluster_585883 V1201263 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_566838 V1201264 S fad dependent oxidoreductase COG2509 Cluster_569927 V1201270 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_573132 V1201275 V Type I Restriction COG0732 Cluster_632777 V1201280 FUCP G glucose galactose transporter COG0738 Cluster_576355 V1201282 S YitT family COG1284 Cluster_576356 V1201288 S radical SAM domain protein COG0641 Cluster_579446 V1201289 AQPZ G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) COG0580 Cluster_579448 V1201292 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (alpha subunit) COG0587 Cluster_579450 V1201295 MAP2 map00500,map01100 G hydrolase family 65, central catalytic COG1554 Cluster_585886 V1201308 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_855388 V1201310 YQFL S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) COG1806 Cluster_699108 V1201312 map00010 G Glycosyl hydrolase, family 1 COG2723 Cluster_592556 V1201313 M Nucleotidyl transferase COG1208 Cluster_596023 V1201319 SIGH map02020 K RNA polymerase COG1595 Cluster_596024 V1201322 LGAS_0607 T head morphogenesis protein, SPP1 gp7 COG5585 Cluster_832072 V1201323 S NA 0Y3Q9 Cluster_599547 V1201336 HTPG map04141,map04151,map04612,map04621,map04626,map04914,map04915,map05200,map05215 O Molecular chaperone. Has ATPase activity (By similarity) COG0326 Cluster_708383 V1201337 map00230,map01100,map01110 F AICARFT/IMPCHase bienzyme COG0138 Cluster_599548 V1201338 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin 0XQTW Cluster_702199 V1201345 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit alpha COG0587 Cluster_606725 V1201347 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG0469 Cluster_606726 V1201349 HISC map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01230 E Imidazole acetol-phosphate transaminase COG0079 Cluster_610389 V1201353 U, W Pfam:YadA COG5295 Cluster_614022 V1201354 map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase COG3958 Cluster_614023 V1201355 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_610390 V1201357 RPSA map00900,map01100,map01110,map03010 J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) COG0539 Cluster_614024 V1201358 S Thiol disulfide interchange protein DsbD 1AKF0@sphNOG Cluster_617809 V1201364 FUCA map00511 G Alpha-L-fucosidase COG3669 Cluster_617810 V1201365 SCLAV_4722 J Methyltransferase COG2813 Cluster_621474 V1201370 DUSB J Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_640841 V1201378 YACP J Tetracycline resistance protein COG3688 Cluster_887877 V1201381 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_912993 V1201383 RPIA map00030,map00710,map01100,map01110,map01120,map01230 G phosphoriboisomerase A COG0120 Cluster_640842 V1201395 S (LipO)protein 0YDWI Cluster_731343 V1201403 S NA 0ZHU9 Cluster_644716 V1201408 DAPE1 map00300,map00310,map00330,map00780,map01100,map01110,map01120,map01210,map01230 E peptidase COG0624 Cluster_644717 V1201412 L Inherit from COG: transposase COG3666 Cluster_648773 V1201414 PRFC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) COG4108 Cluster_705260 V1201423 S PAP2 superfamily domain protein 11HHM Cluster_656962 V1201425 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_656963 V1201427 T Histidine kinase COG0642 Cluster_674050 V1201434 S NA 101UU Cluster_678509 V1201436 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) COG0442 Cluster_674051 V1201438 S NA 11NI8 Cluster_678510 V1201439 L Virulence-associated protein e COG5545 Cluster_674052 V1201440 DPNA L helicase COG4646 Cluster_678511 V1201442 K, L domain protein COG0553 Cluster_678512 V1201446 F formate-tetrahydrofolate ligase COG2759 Cluster_785103 V1201450 D, T, Z signal transduction protein with EFhand domain COG5126 Cluster_687446 V1201456 O Inherit from COG: ubiquitin COG5272 Cluster_692027 V1201460 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_105801 V1201469 GLNA map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG0174 Cluster_29302 V1201472 RECG map03440 L ATP-dependent DNA helicase RecG COG1200 Cluster_236082 V1201473 TRPA map00260,map00400,map01100,map01110,map01230 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) COG0159 Cluster_48317 V1201474 S Inherit from NOG: Histidine triad protein 11G35 Cluster_509835 V1201476 BCP O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG1225 Cluster_392937 V1201477 S NA 0YH5F Cluster_13172 V1201478 O cysteine protease COG4870 Cluster_52824 V1201479 HSDS V Restriction modification system DNA (Specificity COG0732 Cluster_796859 V1201480 S Pfam:PhdYeFM 0XWRR Cluster_72151 V1201481 CBIO map02010 P ABC transporter COG1122 Cluster_12074 V1201482 S NA 11YT1 Cluster_632778 V1201483 S mobilization protein 11J0G Cluster_843912 V1201485 S NA 122EK Cluster_3947 V1201486 S Pfam:YadA 126HB Cluster_13625 V1201487 ACTP P p-type ATPase COG2217 Cluster_196142 V1201489 S cell wall binding COG5263 Cluster_33522 V1201490 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_14348 V1201491 PPC map00620,map00680,map00710,map00720,map01100,map01120 C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) COG2352 Cluster_610391 V1201492 SGAB map00053,map01100,map01120,map02060 G PTS System 126BH Cluster_43704 V1201493 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_42596 V1201494 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 Cluster_134259 V1201495 HSDS V restriction modification system DNA specificity domain COG0732 Cluster_6165 V1201497 ADDA L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation COG1074 Cluster_7298 V1201498 K TRANSCRIPTIONal 11ZCE Cluster_2203 V1201499 S NA 0YG6V Cluster_198877 V1201500 APBA map00770,map01100,map01110 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) COG1893 Cluster_30351 V1201501 S Putative cell wall binding repeat 0YEGX Cluster_195290 V1201502 PRMA J Methylates ribosomal protein L11 (By similarity) COG2264 Cluster_377032 V1201503 S NA 11RJG Cluster_102791 V1201504 MURE map00300,map00550 M mur ligase COG0769 Cluster_432948 V1201505 MAF D MAF-like protein COG0424 Cluster_133475 V1201506 FLIC map02020,map02040,map04626,map05132,map05134 N Flagellin COG1344 Cluster_23283 V1201507 ACTP1 P Copper-exporting ATPase COG2217 Cluster_118395 V1201508 V Mate efflux family protein COG0534 Cluster_324511 V1201509 S Membrane COG1811 Cluster_644718 V1201510 RPLU map03010 J This protein binds to 23S rRNA in the presence of protein L20 (By similarity) COG0261 Cluster_50156 V1201511 S NA 0YIAW Cluster_9984 V1201512 U, W domain protein COG5295 Cluster_180317 V1201513 S domain protein 0YF83 Cluster_30477 V1201514 F ATP cone domain COG1328 Cluster_576357 V1201517 CCEL_3034 S NA 0XYGI Cluster_3625 V1201518 M Inherit from COG: peptidase' 0XPHJ Cluster_74180 V1201522 BL00983 S Phage Portal Protein 11QNG Cluster_13125 V1201523 AMET_0415 S phage protein 0Y97T Cluster_93743 V1201528 BL03493 L phage plasmid primase, p4 family COG4983 Cluster_192590 V1201529 S YqaJ-like viral recombinase domain 125D5 Cluster_18955 V1201530 L DNA polymerase 0Y9P0 Cluster_118396 V1201531 L snf2 family COG0553 Cluster_85112 V1201532 L Resolvase COG1961 Cluster_10190 V1201534 S Relaxase Mobilization nuclease domain protein 0XRAY Cluster_57513 V1201535 U Type IV secretory pathway VirD4 COG3505 Cluster_272369 V1201536 S NA 11Z1K Cluster_228933 V1201537 S NA 126B8 Cluster_917390 V1201538 S NA 0Y6R4 Cluster_20999 V1201540 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG1214 Cluster_315317 V1201541 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_29071 V1201542 CIRA P Receptor COG4771 Cluster_272370 V1201543 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_256423 V1201544 TERC P Membrane protein terC COG0861 Cluster_54750 V1201545 YFMR S abc transporter COG0488 Cluster_171962 V1201546 V restriction endonuclease 0Z1AJ Cluster_146505 V1201547 V ATPase associated with various cellular activities aaa_5 COG1401 Cluster_347299 V1201549 V DNA methylase COG0863 Cluster_188168 V1201550 DCM map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_820519 V1201551 L DNA binding domain protein, excisionase family 121NU Cluster_585888 V1201552 L DNA methylase COG2189 Cluster_104589 V1201553 RMUC S Dna recombination protein COG1322 Cluster_273700 V1201554 TRPF map00400,map01100,map01110,map01230 E N-(5'-phosphoribosyl)anthranilate isomerase COG0135 Cluster_432949 V1201555 EFP J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) COG0231 Cluster_5343 V1201556 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_262952 V1201557 CHEX-4 S NA 11NTE Cluster_25496 V1201558 PRIA map03440 L Primosomal protein n' COG1198 Cluster_79475 V1201559 HSDM V type I restriction-modification system COG0286 Cluster_365283 V1201560 M Transglycosylase SLT domain 0ZC8U Cluster_507238 V1201561 S toxin-antitoxin system, antitoxin component, Xre family 0ZIHY Cluster_196143 V1201562 L site-specific recombinase, phage integrase family 11IW4 Cluster_462 V1201563 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_51322 V1201564 map00020,map00190,map00250,map00623,map00650,map00720,map00760,map01100,map01110,map01120,map05134 C Fumarate reductase succinate dehydrogenase flavoprotein domain-containing protein COG1053 Cluster_273 V1201565 FAS map00061,map01100 I fatty acid synthase COG4982 Cluster_249037 V1201566 M hydrolase, family 25 COG3757 Cluster_65994 V1201567 L Site-specific recombinase COG1961 Cluster_59344 V1201568 S Inherit from NOG: domain protein 0XXVB Cluster_30231 V1201569 V Type III restriction enzyme, res subunit 0ZVEA Cluster_51918 V1201570 OCAR_4032 S Domain of unknown function DUF87 COG0433 Cluster_303655 V1201571 S NA 11IAR Cluster_239872 V1201572 S Inherit from NOG: Relaxase/Mobilisation nuclease domain 0XT8X Cluster_195291 V1201573 HPAIIM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_515108 V1201574 VSR L DNA mismatch endonuclease Vsr COG3727 Cluster_44485 V1201575 S NA 129DJ Cluster_63743 V1201580 HEMA map00860,map01100,map01110 H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) COG0373 Cluster_289968 V1201582 S NA 0ZNPR Cluster_88567 V1201584 BL00983 S Phage Portal Protein 11QNG Cluster_780933 V1201587 S NA 1228P Cluster_89970 V1201590 S phage plasmid primase, p4 family COG3378 Cluster_310711 V1201591 S Inherit from COG: Virulence-associated protein e COG4983 Cluster_197887 V1201595 S YqaJ-like viral recombinase domain 125D5 Cluster_21765 V1201596 L DNA polymerase 0Y9P0 Cluster_79782 V1201598 map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_108175 V1201599 L Inherit from COG: type iii restriction protein res subunit COG1061 Cluster_414339 V1201601 S NA 11M9C Cluster_85113 V1201602 S G5 COG3583 Cluster_188169 V1201603 ORFL L transposase COG2826 Cluster_156092 V1201604 HSDS V restriction COG0732 Cluster_162878 V1201605 S NA 1784J@proNOG Cluster_94163 V1201606 U, W Domain-Containing protein COG5295 Cluster_382302 V1201607 RSMG M Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) COG0357 Cluster_8292 V1201609 U, W Pfam:YadA COG5295 Cluster_3438 V1201610 U, W Inherit from COG: domain protein COG5295 Cluster_69934 V1201611 MPHA S Aminoglycoside phosphotransferase 0YEJ0 Cluster_128888 V1201612 XYLR G, K ROK family COG1940 Cluster_12525 V1201613 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_11026 V1201614 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_17369 V1201615 HYPF O hydrogenase maturation protein Hypf COG0068 Cluster_268381 V1201616 S NA 12BZ7 Cluster_28964 V1201618 PFLB map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_264336 V1201622 S NA 12B6B Cluster_17066 V1201623 SCLAV_1560 map02010 P ABC transporter COG1122 Cluster_67516 V1201625 AHPF O Alkyl hydroperoxide reductase COG3634 Cluster_353712 V1201627 S NA 0Y67R Cluster_2688 V1201628 MT3296 L helicase COG0210 Cluster_25308 V1201629 PEPN map00480,map01100 E aminopeptidase N COG0308 Cluster_777243 V1201632 S NA 0Z0D1 Cluster_36396 V1201633 S peptidase 0XPBV Cluster_20545 V1201634 S Inherit from COG: leucine Rich Repeat COG4886 Cluster_414340 V1201636 CVRA P Participates in control of cell volume in low-osmolarity conditions (By similarity) COG3263 Cluster_6037 V1201637 NIFJ map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map00910,map01100,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_94164 V1201638 U, W Domain-Containing protein COG5295 Cluster_6007 V1201639 U, W Pfam:YadA COG5295 Cluster_98430 V1201640 map03440 K Inherit from bactNOG: transcriptional regulator COG2865 Cluster_711472 V1201641 V Abi-like protein COG4823 Cluster_773505 V1201642 L Inherit from COG: transposase COG2826 Cluster_70537 V1201643 U, W Domain-Containing protein COG5295 Cluster_63459 V1201644 U, W surface protein COG5295 Cluster_170313 V1201645 S NA 0Y5M6 Cluster_702200 V1201646 S rRNA biogenesis protein Rrp5 0XUK3 Cluster_44486 V1201647 POLA_2 L DNA polymerase 0XRUF Cluster_31841 V1201648 L phage plasmid primase, p4 family COG3378 Cluster_119887 V1201649 K, L domain protein COG0553 Cluster_560701 V1201650 S NA 11PZU Cluster_542941 V1201651 V Hnh endonuclease COG1403 Cluster_305157 V1201652 COMEA L Competence protein COG1555 Cluster_29570 V1201653 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_61268 V1201654 S NA 11H5S Cluster_30834 V1201657 S NA 126EM Cluster_191656 V1201661 L Reverse transcriptase COG3344 Cluster_537274 V1201663 S toxin secretion phage lysis holin COG4824 Cluster_407 V1201665 U, W Inherit from COG: domain protein COG5295 Cluster_377034 V1201666 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_127483 V1201667 map03060,map03070 U sec-independent protein 0ZXQT Cluster_9756 V1201668 SP_0498 map00511 G endo-beta-N-acetylglucosaminidase COG4724 Cluster_211600 V1201670 S NA 0YA7S Cluster_347300 V1201671 GLNR K transcriptional regulator COG0745 Cluster_310712 V1201672 S NA 17944@proNOG Cluster_502277 V1201677 L DNA alkylation repair enzyme 0YG23 Cluster_475699 V1201678 M RHS repeat-associated core domain protein COG3209 Cluster_762101 V1201680 S Protein of unknown function (DUF3046) 127S9 Cluster_74810 V1201681 F Uracil permease COG2233 Cluster_16333 V1201683 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_773506 V1201686 MSC_0172 L Transposase 0XS5E Cluster_172870 V1201687 FECB map02010 P Periplasmic binding protein COG0614 Cluster_178615 V1201688 S ABC transporter 124C1 Cluster_352045 V1201689 S B3 4 domain protein COG3382 Cluster_66575 V1201690 P Arylsulfatase COG3119 Cluster_113498 V1201691 M Glycosyl transferase family 2 COG0463 Cluster_7815 V1201693 S Inherit from NOG: antigen PG97 COG4886 Cluster_178616 V1201694 AATB map02010 E ABC transporter substrate-binding protein 0XQ2S Cluster_463003 V1201696 S Filamentation induced by cAMP protein fic 11MJJ Cluster_217324 V1201697 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_454931 V1201701 L Pfam:Transposase_11 0ZVJY Cluster_380533 V1201703 CAS1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) COG1518 Cluster_515109 V1201704 PULA map00500,map01100,map01110 G Glycogen debranching enzyme COG1523 Cluster_126095 V1201705 S histidine acid phosphatase 0YPZX Cluster_146506 V1201707 O phage portal protein HK97 family COG4695 Cluster_617811 V1201708 S prophage pi2 protein 38 11U3I Cluster_226620 V1201710 S NA 0ZJXE Cluster_405357 V1201711 MUG L U mismatch-specific DNA glycosylase COG3663 Cluster_87257 V1201713 RARA L recombination factor protein RarA COG2256 Cluster_298169 V1201714 K Transcriptional Regulator, LuxR family 0Y1WM Cluster_22018 V1201715 M Inherit from NOG: Polymorphic outer membrane protein 11KKP Cluster_208345 V1201716 E, G Membrane COG0697 Cluster_268382 V1201717 FMT S decarboxylase family COG1611 Cluster_198878 V1201719 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG2852 Cluster_31081 V1201720 S Inherit from NOG: cytoplasmic protein 17X18@proNOG Cluster_714858 V1201721 S helicase COG3972 Cluster_79783 V1201722 CG2937 E Extracellular solute-binding protein, family 5 COG0747 Cluster_211601 V1201723 GLCK map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G ROK family COG1940 Cluster_176120 V1201724 P Sulfatase COG3119 Cluster_59070 V1201727 Y0750 S Conserved Protein COG1479 Cluster_436911 V1201728 RESA2 O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG0526 Cluster_82536 V1201730 U TraG family COG3505 Cluster_796860 V1201731 S NA 11U17 Cluster_281698 V1201732 map03440 K Divergent AAA domain protein COG2865 Cluster_683057 V1201733 K Inherit from firmNOG: Transcriptional regulator COG2865 Cluster_396537 V1201734 TOPB L Dna topoisomerase COG0550 Cluster_754852 V1201735 TOPB L Dna topoisomerase COG0550 Cluster_11727 V1201739 map00500,map01100 N Alpha-L-fucosidase 0XPGV Cluster_421496 V1201740 YABB map00340,map00350,map00624,map01120 L Methyltransferase COG4123 Cluster_95697 V1201743 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_79476 V1201744 S NA 0YEPS Cluster_10262 V1201745 S NA 126VW Cluster_79153 V1201746 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_172871 V1201747 M glycosyltransferase group 2 family protein COG0463 Cluster_126793 V1201748 S Filamentation induced by cAMP protein fic COG3177 Cluster_166875 V1201750 map02010 P Periplasmic binding protein COG0614 Cluster_363544 V1201752 PCP O Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) COG2039 Cluster_24692 V1201754 S NA 0YRUB Cluster_219613 V1201756 LPLA map00785,map01100 H Lipoate-protein, ligase COG0095 Cluster_57766 V1201759 M Cell wall anchor domain protein 11Q8J Cluster_231249 V1201760 map00130,map01100,map01110 S Methyltransferase 125X9 Cluster_19288 V1201761 PROTEASE map05120 O peptidase, U32 COG0826 Cluster_195292 V1201762 map00051,map00520,map01100 M RmlD substrate binding domain COG1089 Cluster_152040 V1201763 FCL map00051,map00520,map01100 M Nad-dependent epimerase dehydratase COG0451 Cluster_167670 V1201766 S NA 0XPM9 Cluster_309271 V1201767 GPM2 map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_754853 V1201768 INFA J however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) COG0361 Cluster_5487 V1201770 U, W Inherit from COG: domain protein 121KM Cluster_780934 V1201771 ASD map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) COG0136 Cluster_208346 V1201772 map02010 E branched-chain amino acid ABC transporter, permease COG4177 Cluster_10966 V1201776 SP_0498 G endo-beta-N-acetylglucosaminidase COG4724 Cluster_56247 V1201777 S (LipO)protein 1AJ0J@sphNOG Cluster_592558 V1201779 S NA 0XNWW Cluster_724793 V1201781 S NA 0ZDIF Cluster_718124 V1201782 S Inherit from NOG: Plasmid stabilization system 0XUXM Cluster_60388 V1201783 G glycoside hydrolase, family COG1626 Cluster_262953 V1201784 FABD map00061,map01100 I malonyl CoA-acyl carrier protein transacylase COG0331 Cluster_90420 V1201785 U, W domain protein COG5295 Cluster_44833 V1201786 U, W domain protein COG5295 Cluster_300812 V1201789 PUNA map00230,map00240,map00760,map01100,map01110 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) COG0005 Cluster_170314 V1201790 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_99480 V1201791 YEGQ map05120 O Peptidase U32 COG0826 Cluster_352046 V1201792 GNTR K Transcriptional regulator, GntR family COG1802 Cluster_33388 V1201795 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_138984 V1201800 BMUL_5034 S Aminoglycoside phosphotransferase 0ZRQS Cluster_80894 V1020002 S NA 0YENI Cluster_181018 V1020003 T Histidine kinase 0ZPYN Cluster_218219 V1020004 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_282844 V1020007 S NA 0YYM2 Cluster_272111 V1020008 OCAR_7318 map02030,map02040 N Ompa motb domain protein COG1360 Cluster_307652 V1020011 L TatD-related deoxyribonuclease COG0084 Cluster_310433 V1020012 H uba thif-type nad fad binding protein COG1179 Cluster_780079 V1020015 S NA 0ZHU9 Cluster_330207 V1020018 map02010 P Cobalt transport protein COG0619 Cluster_75416 V1020023 PEPD E Dipeptidase COG4690 Cluster_336278 V1020024 S repeat-containing protein COG0457 Cluster_827715 V1020025 TIG O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COG0544 Cluster_424779 V1020026 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_390808 V1020027 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_270814 V1020029 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_188869 V1020030 FADE23 map00071,map00280,map00410,map00640,map01100,map01110,map03320 I acyl-Coa dehydrogenase 0XP8P Cluster_173565 V1020031 FAS map00061,map00350,map00362,map00627,map00642,map00903,map01100,map01120 I synthase COG4982 Cluster_390809 V1020033 S dedA family COG0586 Cluster_501733 V1020034 GLDH S gliding motility-associated lipoprotein GldH 0ZU07 Cluster_237053 V1020037 PURC map00230,map01100,map01110 F SAICAR synthetase COG0152 Cluster_340733 V1020039 SAPB S MgtC SapB transporter COG1285 Cluster_82057 V1020044 PLCN map00562,map00564,map00565,map01100 M phospholipase C COG3511 Cluster_668862 V1020045 S Alpha Beta Hydrolase COG4757 Cluster_79425 V1020046 C Thiol oxidoreductase COG3488 Cluster_262723 V1020048 DAPA map00300,map01100,map01110,map01120,map01230 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) COG0329 Cluster_232203 V1020049 S EamA-like transporter family 0ZWF2 Cluster_373251 V1020050 SDAAB map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase, iron-sulfur-dependent, beta subunit COG1760 Cluster_287054 V1020051 S Porphyromonas gingivalis family protein 11XDU Cluster_65629 V1020053 COMEC S DNA internalization-related competence protein ComEC Rec2 COG2333 Cluster_88973 V1020054 HUTH map00340,map01100 E Histidine ammonia-lyase COG2986 Cluster_201683 V1020055 M Sortase family COG3764 Cluster_247515 V1020056 CPSY K Transcriptional regulator COG0583 Cluster_737189 V1020057 S Orthopoxvirus protein of unknown function (DUF830) 0XXPF Cluster_635911 V1020059 S esterase 1294K Cluster_161895 V1020060 NQRB C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG1805 Cluster_355029 V1020064 MAF D MAF-like protein COG0424 Cluster_677630 V1020067 K RNA Polymerase COG1595 Cluster_192440 V1020068 S Radical SAM superfamily COG0535 Cluster_548273 V1020069 S oxidoreductase 11WN8 Cluster_417559 V1020071 RECX S regulatory protein RecX 125BK Cluster_501734 V1020072 S Secreted protein 11Z2N Cluster_254995 V1020073 O sucraseferredoxin family COG4759 Cluster_328828 V1020074 T stage II sporulation protein 11QTH Cluster_246264 V1020077 YITL S S1 RNA binding domain protein COG2996 Cluster_321093 V1020078 LOLD map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_761320 V1020079 S NA 0ZXH1 Cluster_239634 V1020080 S ParB-like nuclease domain 0ZJMC Cluster_343814 V1020081 S Phosphoadenosine phosphosulfate reductase 0ZVY8 Cluster_146368 V1020082 L integrase family 0XRS7 Cluster_499195 V1020083 S Domain of unknown function (DUF1896) 11Y7P Cluster_394338 V1020085 FOLE map00790,map01100 H GTP cyclohydrolase i COG0302 Cluster_572439 V1020086 S doxx family COG2259 Cluster_250066 V1020087 MT1025 S conserved transmembrane protein 12614 Cluster_374954 V1020092 MIP O Peptidyl-prolyl cis-trans isomerase COG0545 Cluster_339277 V1020093 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_325725 V1020094 RECO map03440 L Involved in DNA repair and RecF pathway recombination (By similarity) COG1381 Cluster_394339 V1020096 HSAB map00984,map01100 S flavin reductase domain protein, FMN-binding COG1853 Cluster_419279 V1020099 DEF J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) COG0242 Cluster_257467 V1020100 K acetyltransferase COG0454 Cluster_217102 V1020102 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_389057 V1020103 M hydrolase, family 25 COG3757 Cluster_61506 V1020104 ECTP P Transporter COG1292 Cluster_376671 V1020106 LEXA K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) COG1974 Cluster_174363 V1020107 PABB map00400,map00790,map01100,map01110,map01230 E, H synthase component I COG0147 Cluster_327289 V1020108 BETP P Transporter COG1292 Cluster_72432 V1020111 map00051,map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 G Glycosyl hydrolase family 20 COG3525 Cluster_243645 V1020113 S SPP1 gp7 family 12A6V Cluster_322668 V1020117 PPGK map00010,map00520,map01100,map01110,map01120 G Polyphosphate glucokinase COG1940 Cluster_387323 V1020118 SUHB map00521,map00562,map01100,map01110,map04070 G inositol monophosphatase COG0483 Cluster_103891 V1020119 S NA 11QTV Cluster_475245 V1020120 TPX O Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) COG2077 Cluster_704616 V1020121 SCLAV_1355 K AsnC family transcriptional regulator COG1522 Cluster_296555 V1020122 MT0809 C fumarate reductase succinate dehydrogenase flavoprotein domain protein COG3573 Cluster_166732 V1020123 MRDA map00550 M Penicillin-binding protein 2 COG0768 Cluster_303365 V1020127 COAX map00770,map01100 K Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) COG1521 Cluster_686550 V1020128 PANC map00410,map00770,map01100,map01110 H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) COG0414 Cluster_698505 V1020129 S Cell division protein ZapA 0YIVA Cluster_695136 V1020130 S NA 0XW6Q Cluster_730719 V1020133 S Signal peptide protein, YSIRK family 1293E Cluster_238351 V1020135 S phage protein 0XQDU Cluster_172706 V1020139 G Major Facilitator superfamily 0XQFH Cluster_339278 V1020140 YFMJ map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120 S Alcohol dehydrogenase zinc-binding domain protein COG2130 Cluster_211384 V1020142 PITA P phosphate transporter COG0306 Cluster_380169 V1020143 YKAA P phosphate transport regulator COG1392 Cluster_82467 V1020145 CYDD map02010 V ABC, transporter COG4988 Cluster_440527 V1020148 HXLB map00030,map00040,map00680,map01100,map01120,map01230 G 6-phospho 3-hexuloisomerase COG0794 Cluster_389058 V1020149 HXLA map00030,map00040,map00680,map01100,map01120,map01230 G 3-hexulose-6-phosphate synthase COG0269 Cluster_647915 V1020151 ORF010 S Staphylococcal protein of unknown function (DUF960) 1265C Cluster_470991 V1020152 CCU S Protein of unknown function (DUF1643) COG4333 Cluster_479817 V1020154 MT3328 S NA 11M1Z Cluster_309017 V1020155 METN map02010 P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COG1135 Cluster_184520 V1020156 AROE map00400,map01100,map01110,map01230 E shikimate dehydrogenase COG0169 Cluster_248823 V1020159 S structural protein 11RQ6 Cluster_293744 V1020161 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_740677 V1020162 RPMC map03010 J 50s ribosomal protein l29 COG0255 Cluster_318123 V1020163 C 4Fe-4S ferredoxin, iron-sulfur binding COG1145 Cluster_454548 V1020164 K RNA Polymerase COG1595 Cluster_132495 V1020166 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_440528 V1020167 HIT F, G Histidine triad (Hit) protein COG0537 Cluster_170171 V1020168 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_184521 V1020169 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_269496 V1020174 PYRF map00240,map01100 F orotidine 5''-phosphate decarboxylase COG0284 Cluster_228717 V1020175 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_116902 V1020181 RNFC C Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) COG4656 Cluster_428583 V1020182 RFBC map00521,map00523,map01100,map01110 M Dtdp-4-dehydrorhamnose 3,5-epimerase COG1898 Cluster_103317 V1020183 S S-layer domain protein 11R54 Cluster_244921 V1020186 FTSX map02010 D Part of the ABC transporter FtsEX involved in cellular division (By similarity) COG2177 Cluster_303366 V1020189 NUCS L Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) COG1637 Cluster_371629 V1020195 map00190 C Nitroreductase COG0778 Cluster_691175 V1020196 ADA L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) COG0350 Cluster_664516 V1020197 S ABC transporter, ATPase COG3044 Cluster_306285 V1020198 TIPA K Transcriptional regulator COG0789 Cluster_664517 V1020199 BMUL_0638 G domain protein COG0662 Cluster_343815 V1020200 CMK map00240,map00410,map00770,map01100,map01110 F Cytidine monophosphate kinase COG0283 Cluster_132631 V1201801 MUTS2 L DNA mismatch repair protein COG0249 Cluster_1886 V1201802 U, W Inherit from COG: domain protein COG5295 Cluster_182072 V1201804 ERYC E DegT DnrJ EryC1 StrS COG0399 Cluster_432950 V1201806 V Restriction modification system DNA (Specificity COG0732 Cluster_416123 V1201807 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_136680 V1201808 AROA map00400,map01100,map01110,map01230 E 3-phosphoshikimate 1-carboxyvinyltransferase COG0128 Cluster_26148 V1201811 V abc transporter permease protein 11F1K Cluster_371935 V1201812 map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_338100 V1201815 S CAAX amino terminal protease family 0XUJM Cluster_309272 V1201816 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_47285 V1201817 S NA 12BGB Cluster_2486 V1201818 S NA 101UU Cluster_50956 V1201820 U, W Domain-Containing protein COG5295 Cluster_45566 V1201821 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_344096 V1201822 Q Methyltransferase COG0500 Cluster_288672 V1201824 map00061,map00072,map00650,map00780,map01040,map01100 I, Q short-chain dehydrogenase reductase COG1028 Cluster_17886 V1201827 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_89054 V1201828 FPRB map00250,map00910,map01100,map01110,map01120,map01230 C reductase COG0493 Cluster_307856 V1201830 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_128179 V1201831 S NA 11R7X Cluster_46140 V1201832 LYTC map00511 S Glycosyl hydrolases family 25 COG5263 Cluster_195293 V1201835 NRNA J phosphoesterase RecJ domain protein COG0618 Cluster_475700 V1201836 S Acyltransferase family 0YFSP Cluster_3706 V1201837 L adenine specific DNA methyltransferase COG4889 Cluster_62898 V1201838 ABIR S abortive phage infection 0XQE9 Cluster_428966 V1201839 AGUB map00330,map01100 S hydrolase, carbon-nitrogen family COG0388 Cluster_197888 V1201840 AGUA map00330,map01100 E Agmatine deiminase COG2957 Cluster_291276 V1201841 RPH map00230,map00240,map01100 J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) COG0689 Cluster_184672 V1201842 M glycosyl transferase group 1 11PET Cluster_473573 V1201844 CKL_1868 S NA 0XRCN Cluster_3328 V1201846 S NA 101UU Cluster_253988 V1201847 RRMJ J Hemolysin A COG1189 Cluster_531586 V1201848 L transposase 0XQMH Cluster_201875 V1201849 S cytosolic protein 0XSPM Cluster_209387 V1201851 S filamentation induced by cAMP protein Fic COG3177 Cluster_53782 V1201854 PGCA map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_3560 V1201855 S NA 101UU Cluster_487236 V1201856 SP_0119 L Nudix family COG0494 Cluster_101136 V1201858 V Type II restriction 0XSKF Cluster_316847 V1201860 CP_0141 S metallophosphoesterase COG1768 Cluster_211602 V1201861 PITA P phosphate transporter COG0306 Cluster_352047 V1201862 YKAA P phosphate transport regulator COG1392 Cluster_3806 V1201863 S NA 0YZ82 Cluster_22019 V1201865 S conjugation system ATPase, TraG family 0XSHU Cluster_18205 V1201867 UVRD2 map03420,map03430 L helicase COG0210 Cluster_484959 V1201868 ELI_1297 O phage portal protein HK97 family COG4695 Cluster_157806 V1201869 ELI_1299 S Phage major capsid protein COG4653 Cluster_11858 V1201871 M Inherit from COG: domain protein COG4932 Cluster_839812 V1201872 S NA 0XXBY Cluster_306543 V1201873 OMP28 M outer membrane protein Omp28 127K8 Cluster_32441 V1201875 map02020,map02030 S Methyl-accepting chemotaxis protein (MCP) signalling domain COG0840 Cluster_221965 V1201876 M Cell wall anchor domain protein 11Q8J Cluster_24066 V1201877 T EAL 0XNMH Cluster_130329 V1201878 M Inherit from NOG: Polysaccharide Biosynthesis Protein 0XP95 Cluster_105182 V1201880 CLCAR_1091 T Histidine kinase COG0642 Cluster_162029 V1201882 CLOSA_0730 V Hnh endonuclease COG1479 Cluster_178617 V1201883 ECORIM L Modification methylase EcoRI 0XPU0 Cluster_294019 V1201884 SCLAV_4781 S Protein of unknown function (DUF3710) 11QDA Cluster_40860 V1201885 DPPD map02010 S ABC transporter COG1123 Cluster_100554 V1201886 PBUG S Xanthine uracil vitamin C permease COG2252 Cluster_174512 V1201888 V ABC transporter transmembrane region COG1132 Cluster_5319 V1201891 U, W Inherit from COG: domain protein 121KM Cluster_255201 V1201892 OCAR_7318 map02030,map02040 N Ompa motb domain protein COG1360 Cluster_5124 V1201894 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_109423 V1201895 PARE L DNA topoisomerase IV subunit B COG0187 Cluster_21849 V1201896 S Inherit from COG: leucine Rich Repeat COG4886 Cluster_170315 V1201898 M Lipopolysaccharide biosynthesis protein-like protein COG3754 Cluster_8953 V1201902 S NA 11QZ9 Cluster_17973 V1201903 L helicase COG1204 Cluster_804971 V1201905 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_291277 V1201907 PGL map00030,map01100,map01110,map01120 G 6-phosphogluconolactonase (EC 3.1.1.31) COG0363 Cluster_542942 V1201909 SCLAV_0149 S Glyoxalase Bleomycin resistance protein (Dioxygenase 1228Z Cluster_289969 V1201910 LSGF M glycosyltransferase COG0463 Cluster_200877 V1201912 PANE map00770,map01100,map01110 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) COG1893 Cluster_36683 V1201913 RLMC map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) COG2265 Cluster_283101 V1201918 S Recombinase 0Y2JQ Cluster_92356 V1201920 L helicase COG4646 Cluster_152041 V1201921 THII map00730,map01100,map04122 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) COG0301 Cluster_300813 V1201926 D CobQ CobB MinD ParA nucleotide binding domain protein COG1192 Cluster_190742 V1201928 U, W Pfam:YadA COG5295 Cluster_162030 V1201931 VPS70 map00360,map01120 Q Coenzyme F390 synthetase-like protein COG1541 Cluster_296766 V1201933 S kila-n, DNA-binding domain 0XPNQ Cluster_177780 V1201934 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_291278 V1201935 S NA 11J85 Cluster_708384 V1201936 L DNA packaging protein 123DA Cluster_184673 V1201937 CLOSA_0730 V Hnh endonuclease COG1479 Cluster_182073 V1201939 V Type I restriction modification DNA specificity domain COG0732 Cluster_219614 V1201940 L recombinase (Phage integrase family) COG0582 Cluster_214993 V1201941 E Amino acid or sugar ABC transport system, permease protein COG1079 Cluster_145708 V1201942 YCEG F aminodeoxychorismate lyase COG1559 Cluster_12075 V1201944 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_103995 V1201945 PYRC map00240,map01100 F dihydroorotase COG0044 Cluster_378813 V1201946 S Endonuclease Exonuclease phosphatase 126QX Cluster_15775 V1201948 PPC map00620,map00680,map00710,map00720,map01100,map01120 C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) COG2352 Cluster_96803 V1201950 GLGA map00500,map01100,map01110,map04973 G Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) COG0297 Cluster_12877 V1201951 U, W Inherit from COG: domain protein COG5295 Cluster_127484 V1201952 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_515111 V1201953 S Transcriptional regulator 11MVX Cluster_22277 V1201954 S NA 0ZHYV Cluster_134260 V1201955 SP_1634 S Protein of unknown function (DUF2974) 0XSVF Cluster_114874 V1201957 CAPA M Capsule synthesis protein COG2843 Cluster_380534 V1201958 S NA 0YB4U Cluster_430933 V1201959 S domain protein 0XNZW Cluster_255202 V1201960 WHIA K May be required for sporulation (By similarity) COG1481 Cluster_197889 V1201962 GLUQ map00860,map00970,map01100,map01110 J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) COG0008 Cluster_260335 V1201963 M group 2 family COG0463 Cluster_226621 V1201965 S Acyltransferase family 0YSHG Cluster_39146 V1201966 S TPR repeat-containing protein COG0457 Cluster_482638 V1201967 S NA 11QRM Cluster_54996 V1201969 S Metalloprotease MEP1-like protein 0XPH7 Cluster_102246 V1201970 ASPA map00250,map00910,map01100 E Aspartate ammonia-lyase COG1027 Cluster_50572 V1201971 map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_96804 V1201972 O m6 family metalloprotease domain protein COG4412 Cluster_392938 V1201973 COBQ S Glutamine amidotransferase COG3442 Cluster_21555 V1201974 S domain protein 0XPXI Cluster_111425 V1201975 FUMC map00020,map00720,map01100,map01110,map01120,map05200,map05211 C fumarate hydratase class II COG0114 Cluster_610393 V1201978 L endonuclease I COG2356 Cluster_16608 V1201979 PACL2 P Atpase, p-type (Transporting), had superfamily, subfamily ic COG0474 Cluster_333524 V1201980 GLPQ map00564 C glycerophosphoryl diester phosphodiesterase COG0584 Cluster_168520 V1201982 S phage protein 0XQDU Cluster_44285 V1201983 L adenine specific DNA methylase COG2189 Cluster_140504 V1201984 map00010,map00710,map01100,map01110,map01120,map01230 G phosphoglycerate kinase COG0126 Cluster_497079 V1201985 SLGD_00064 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_19203 V1201986 ISDE map02010 P (ABC) transporter COG0614 Cluster_198879 V1201987 OPPD E, P ABC transporter COG0444 Cluster_253989 V1201988 MRR V restriction COG1715 Cluster_255203 V1201989 S NA 0XPA9 Cluster_56496 V1201990 ARGS map00970 J arginyL-tRNA synthetase COG0018 Cluster_91857 V1201991 ADHE map00010,map00051,map00071,map00350,map00362,map00363,map00591,map00620,map00621,map00622,map00625,map00626,map00650,map01100,map01110,map01120 C Dehydrogenase COG1454 Cluster_324512 V1201995 RPH map00230,map00240,map01100 J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) COG0689 Cluster_287314 V1201998 S Domain of unknown function (DUF1980) COG3689 Cluster_287315 V1201999 THYA map00240,map00670,map01100 F Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) COG0207 Cluster_256425 V1202000 M glycosyltransferase group 2 family protein COG0463 Cluster_324513 V1202001 GUML S ExoV domain protein 11PEJ Cluster_477903 V1202002 I Lipid kinase, YegS Rv2252 BmrU family COG1597 Cluster_392939 V1202003 K Transcriptional Regulator, LuxR family 0Y1WM Cluster_482639 V1202004 S Protein of unknown function (DUF1312) 0ZY08 Cluster_74811 V1202005 YFJK L domain protein COG1204 Cluster_249038 V1202007 ATPG map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) COG0224 Cluster_58795 V1202009 map02010 V ABC transporter COG1132 Cluster_98431 V1202010 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_762102 V1202011 S NA 0ZXT9 Cluster_762103 V1202012 OCAR_6158 L Terminase, large subunit COG4626 Cluster_287316 V1202013 S Porphyromonas gingivalis family protein 11XDU Cluster_122825 V1202014 S NA 0XSI9 Cluster_357067 V1202016 PYRF map00240,map01100 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) COG0284 Cluster_573134 V1202017 S NA 0Y9Z0 Cluster_231250 V1202018 FADD15 map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG1022 Cluster_27270 V1202019 P TonB-dependent receptor Plug 0XNPQ Cluster_32995 V1202020 S NA 101UU Cluster_71231 V1202026 S NA 0YBPX Cluster_237280 V1202029 PFLX S radical SAM domain protein COG1313 Cluster_284468 V1202031 CCEL_1484 L Integrase COG2801 Cluster_352048 V1202032 WBEW M sugar transferase COG2148 Cluster_61556 V1202033 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG0469 Cluster_375268 V1202035 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_52590 V1202036 HSDS V Restriction modification system DNA (Specificity COG0732 Cluster_33636 V1202037 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_40861 V1202040 S p-loop domain protein COG4928 Cluster_569928 V1202041 HTRA map03010 O protease COG0265 Cluster_34350 V1202042 U, W Pfam:YadA COG5295 Cluster_523099 V1202044 map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_423358 V1202045 map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_228934 V1202046 YFIH S Multi-copper polyphenol oxidoreductase laccase COG1496 Cluster_79784 V1202049 S NA 0YAQZ Cluster_348925 V1202051 S OstA-like protein 11YB4 Cluster_399980 V1202053 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_353713 V1202054 AROF map00400,map01100,map01110,map01230 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) COG0722 Cluster_37799 V1202055 V abc transporter permease protein COG0577 Cluster_232418 V1202056 SP_1634 S Protein of unknown function (DUF2974) 0XSVF Cluster_295424 V1202057 S NA 121T2 Cluster_139774 V1202058 NAGA map00520,map01110 G GlcNAc 6-P deacetylase COG1820 Cluster_391127 V1202061 TRMB C Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_75785 V1202062 OPPA E Extracellular solute-binding protein, family 5 COG0747 Cluster_223146 V1202064 TATD L Hydrolase, tatD family COG0084 Cluster_61269 V1202067 AST S Enterotoxin 0YVWS Cluster_41693 V1202068 U, W Pfam:YadA COG5295 Cluster_762104 V1202069 S NA 0YRIH Cluster_480326 V1202070 K Sigma factor 0YGB2 Cluster_477904 V1202071 G Binding-protein-dependent transport systems inner membrane component COG1175 Cluster_96805 V1202072 S S-layer domain protein 0XS72 Cluster_332034 V1202073 map00730,map01100 H thiamine COG1564 Cluster_796862 V1202074 S Pfam:SirA 0ZMJP Cluster_295425 V1202075 P TonB-dependent receptor Plug 0XNPQ Cluster_79154 V1202078 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_260336 V1202079 S NA 0ZC4R Cluster_421497 V1202080 RIMM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) COG0806 Cluster_375269 V1202082 CKL_1850 K phage regulatory protein, rha family COG3646 Cluster_585889 V1202083 S NA 122IS Cluster_201876 V1202085 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_332035 V1202086 STP T Phosphatase COG0631 Cluster_130330 V1202088 M Cell wall binding repeat 2-containing protein 12D0J Cluster_509836 V1202089 OPPF3 map02010 S ABC transporter COG1123 Cluster_557629 V1202090 Q Methyltransferase COG0500 Cluster_471456 V1202091 L Inherit from COG: transposase COG5444 Cluster_51919 V1202092 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_79785 V1202093 S Conserved domain protein 0Y57B Cluster_189876 V1202094 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_133476 V1202096 S Inherit from COG: ATPase (AAA COG1373 Cluster_665364 V1202097 S toxin-antitoxin system, antitoxin component, ribbon-helix-helix 11U5W Cluster_410662 V1202099 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_55753 V1202100 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_144962 V1202101 OCAR_5891 map00020,map00720,map01100,map01110,map01120,map05200,map05211 P iron permease COG0672 Cluster_291279 V1202102 LPTB map02010 S ABC transporter COG1137 Cluster_174513 V1202104 NAGA map00520,map01110 G GlcNAc 6-P deacetylase COG1820 Cluster_463004 V1202105 ALST E amino acid carrier protein COG1115 Cluster_382303 V1202107 S NA 11VCX Cluster_128889 V1202108 P Sodium/hydrogen exchanger family COG0025 Cluster_67148 V1202109 S Pyrogenic exotoxin B 11S8V Cluster_216119 V1202111 map00330,map01110,map01230 E Ornithine Cyclodeaminase COG2423 Cluster_262954 V1202112 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0847 Cluster_363545 V1202113 GLUC map02010 E ABC transporter COG0765 Cluster_144211 V1202114 S NA 0XSI9 Cluster_250301 V1202115 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_295426 V1202116 SCPA S Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) COG1354 Cluster_63744 V1202117 APRE O Inherit from firmNOG: peptidase S8 and S53, subtilisin, kexin, sedolisin COG4412 Cluster_480327 V1202118 DPS P During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction COG0783 Cluster_394744 V1202119 RPLD map03010 J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) COG0088 Cluster_277691 V1202120 K Transcriptional regulator 11GAC Cluster_408802 V1202121 S Pilin isopeptide linkage domain protein 1274N Cluster_67517 V1202122 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_67518 V1202123 YBIT S ABC transporter, ATP-binding protein COG0488 Cluster_91858 V1202124 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_78406 V1202126 S L,D-transpeptidase catalytic domain COG1376 Cluster_355378 V1202129 ELI_1297 O phage portal protein HK97 family COG4695 Cluster_216120 V1202130 S filamentation induced by cAMP protein fic COG3177 Cluster_72153 V1202132 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_261657 V1202133 E peptidase 0XRNU Cluster_170316 V1202134 MDLA V Abc transporter COG1132 Cluster_396538 V1202135 SSTT E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) COG3633 Cluster_86818 V1202137 RECG map03440 L ATP-dependent DNA helicase recG COG1200 Cluster_318412 V1202138 GG9_0942 L transposase COG2801 Cluster_273701 V1202139 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii subunits gamma and tau COG2812 Cluster_156093 V1202141 V Restriction modification system DNA (Specificity COG0732 Cluster_141257 V1202142 L PP-loop domain protein COG1606 Cluster_330474 V1202144 ISPD map00900,map01100,map01110 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COG1211 Cluster_242520 V1202145 PYRC map00230,map00240,map01100,map01120 F dihydroorotase COG0044 Cluster_82119 V1202146 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_195294 V1202147 MODA map02010 P ABC transporter, periplasmic molybdate-binding protein COG0725 Cluster_234885 V1202148 COBW S cobw p47k family protein COG0523 Cluster_131887 V1202149 HSDS V Restriction modification system DNA (Specificity COG0732 Cluster_167671 V1202150 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_652836 V1202151 V DNA specificity domain COG0732 Cluster_824557 V1202152 S Toxin-antitoxin system, toxin component, HicA family 0XUD5 Cluster_540076 V1202153 S Toxin-antitoxin system, antitoxin component, HicB family 12518 Cluster_389401 V1202155 ALKA map03410 L 8-oxoguanine DNA glycosylase COG0122 Cluster_284469 V1202157 S Domain of unknown function (DUF1836) 0ZWQ6 Cluster_551858 V1202158 RPSI map03010 J 30S ribosomal protein S9 COG0103 Cluster_225496 V1202160 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_208347 V1202161 YERB S secreted protein 11FHM Cluster_214994 V1202166 RBSC map02010,map02030 G abc transporter COG1172 Cluster_141258 V1202167 GLNA map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG0174 Cluster_266977 V1202169 L Transposase COG3464 Cluster_96284 V1202170 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_148816 V1202171 YCHF J gtp-binding protein COG0012 Cluster_97876 V1202173 S NA 0YG6V Cluster_428967 V1202174 U, W Pfam:HIM COG5295 Cluster_105183 V1202175 CAFA map03018 J ribonuclease COG1530 Cluster_146507 V1202177 NTPB map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) COG1156 Cluster_105802 V1202180 U, W Pfam:YadA COG5295 Cluster_105803 V1202181 S Lipase (class 3) 0ZJUJ Cluster_296767 V1202182 YAAO map00310,map00330,map00960,map01100,map01110 E decarboxylase COG1982 Cluster_107626 V1202183 M outer membrane autotransporter barrel domain protein COG3468 Cluster_241150 V1202184 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_606727 V1202186 OCAR_6158 L Terminase, large subunit COG4626 Cluster_108176 V1202187 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_454932 V1202189 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_110049 V1202190 S NA 12D73 Cluster_309273 V1202192 METK S methionine adenosyltransferase 0YTXD Cluster_154448 V1202193 RIBBA map00740,map01100 H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) COG0807 Cluster_241151 V1202194 NIRJ L Pyrroloquinoline quinone biosynthesis protein E COG0535 Cluster_773508 V1202196 S NA 11QY9 Cluster_243867 V1202197 XERC L Integrase COG0582 Cluster_338101 V1202198 PSEH map00350,map00362,map00520,map00627,map00642,map00903,map01120 M pseudaminic acid biosynthesis n-acetyl transferase COG1670 Cluster_198880 V1202200 S NA 11F7I Cluster_566841 V1202201 YHGE S domain protein COG1511 Cluster_259034 V1202202 S Uncharacterized protein conserved in bacteria (DUF2179) COG1284 Cluster_699113 V1202207 S YGGT family 0ZT1Y Cluster_124088 V1202208 ATPA map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) COG1155 Cluster_135872 V1202210 map00680,map01120 S Phosphotransferase 0Y7VB Cluster_430934 V1202211 YBEY map00240,map00983,map01100 F Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) COG0319 Cluster_780936 V1202212 SP_0239 S UPF0210 protein COG2848 Cluster_145709 V1202213 SPR M nlp p60 protein COG0791 Cluster_136681 V1202214 E Hydrolase COG0637 Cluster_237281 V1202215 TRMB C Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_560704 V1202216 S NA 11PZU Cluster_358743 V1202217 K, L domain protein COG0553 Cluster_129607 V1202218 S NA 0ZTYV Cluster_156094 V1202219 L site-specific recombinase, phage integrase family 0ZF8H Cluster_332036 V1202226 MTNN map00270,map01100 F Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) COG0775 Cluster_137468 V1202228 S NA 11NI8 Cluster_252733 V1202230 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_355379 V1202231 CSN1 L crispr-associated protein COG3513 Cluster_303656 V1202232 PLSC map00561,map00564,map01100 I Acyl-transferase COG0204 Cluster_142762 V1202233 FADD15 map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG1022 Cluster_146508 V1202234 CARA map00240,map00250,map01100 F carbamoyl-phosphate synthetase glutamine chain COG0505 Cluster_348926 V1202236 V abc transporter permease protein COG0577 Cluster_423359 V1202237 M Inherit from NOG: domain protein 18B9F@proNOG Cluster_261658 V1202239 ATOB map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map02020 I acetyl-coa acetyltransferase COG0183 Cluster_442944 V1202241 U domain protein COG0653 Cluster_296768 V1202242 K Transcriptional regulator, TetR family 11JD6 Cluster_185554 V1202244 S SusD family 0XPTK Cluster_219616 V1202246 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_687452 V1202247 BMUL_0473 S ABC transporter, permease COG4120 Cluster_191657 V1202249 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_162031 V1202250 S NA 0YZ82 Cluster_344097 V1202252 Q methyltransferase COG0500 Cluster_167672 V1202253 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_394745 V1202254 C radical SAM domain protein COG1032 Cluster_534361 V1202255 YYBT T domain protein COG3887 Cluster_239873 V1202256 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_182980 V1202257 NRNA J phosphoesterase RecJ domain protein COG0618 Cluster_724794 V1202258 D, J addiction module toxin, RelE StbE family COG2026 Cluster_792880 V1202259 PRPC3 T PAS PAC sensor protein COG2208 Cluster_350543 V1202260 FTSK D cell division protein FtsK COG1674 Cluster_295427 V1202261 S Hydrolase COG0561 Cluster_175327 V1202264 FLIC map02020,map02040,map04626,map05132,map05134 N Flagellin COG1344 Cluster_287317 V1202267 Q AmP-dependent synthetase and ligase COG0318 Cluster_200878 V1202270 S helicase COG3972 Cluster_275050 V1202272 STRIC_0432 L Transposase (IS4 family 11HCS Cluster_531587 V1202277 FHAB T Fha domain containing protein COG1716 Cluster_371936 V1202278 U, W YadA domain protein COG5295 Cluster_358744 V1202279 S NA 11NM2 Cluster_185555 V1202280 S Pfam:YadA 0ZHSU Cluster_186472 V1202285 S NA 0YZ82 Cluster_375270 V1202286 THID map00730,map01100 H phosphomethylpyrimidine kinase COG0819 Cluster_251524 V1202287 PCCB map00280,map00630,map00640,map00720,map01100,map01120 I carboxyl transferase COG4799 Cluster_512415 V1202289 SEPF S Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) COG1799 Cluster_259035 V1202290 RECG map03440 L ATP-dependent DNA helicase recg COG1200 Cluster_355380 V1202291 SASC S surface protein 11FPX Cluster_728046 V1202292 V ABC transporter COG1132 Cluster_192591 V1202294 S Membrane 0XPGQ Cluster_194412 V1202295 S NA 101UU Cluster_687453 V1202296 L NA 0YKV1 Cluster_313730 V1202297 S Membrane 11NPN Cluster_271043 V1202298 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_225497 V1202299 FRDB map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020 C succinate dehydrogenase COG0479 Cluster_734598 V1202301 PULA map00500,map01100,map04973 G pullulanase COG1523 Cluster_209388 V1202302 GLNE O, T Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) COG1391 Cluster_758402 V1202303 SCLAV_4542 S UPF0109 protein COG1837 Cluster_203962 V1202306 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_226622 V1202307 S Abi-like protein 11VSQ Cluster_205035 V1202308 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_209389 V1202312 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_303657 V1202314 YLME F alanine racemase domain protein COG0325 Cluster_526032 V1202315 RLML L Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) COG1092 Cluster_211603 V1202316 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_576358 V1202319 S NA 0XWWF Cluster_599551 V1202321 YCHF J gtp-binding protein COG0012 Cluster_428968 V1202324 GSPF map03070 U type ii secretion system COG1459 Cluster_256426 V1202325 PPID O Peptidyl-prolyl cis-trans isomerase COG0760 Cluster_582685 V1202329 YACL S PilT protein domain protein COG4956 Cluster_225498 V1202331 U, W Pfam:YadA COG5295 Cluster_265664 V1202332 MUTS2 map03430 L muts2 protein COG1193 Cluster_226623 V1202333 GLGX map00500,map01100,map01110 G glycogen debranching enzyme glgx COG1523 Cluster_463005 V1202334 BMPD S basic membrane COG1744 Cluster_469322 V1202336 SPAT map02010 V ABC transporter 0XPIZ Cluster_230081 V1202337 DLTA Q AMP-binding enzyme COG1020 Cluster_230082 V1202338 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_708385 V1202340 S NA 11UW8 Cluster_531588 V1202341 NMB1132 S T5orf172 domain 10WZH Cluster_692030 V1202342 DIND S DNA-damage-inducible protein d 0XQQP Cluster_454933 V1202343 CARD K Transcriptional regulator (CarD family COG1329 Cluster_234886 V1202344 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_566842 V1202345 TRA L transposase COG2826 Cluster_318413 V1202346 SOJ D Chromosome Partitioning Protein COG1192 Cluster_863690 V1202347 OPPC P Binding-protein-dependent transport systems inner membrane component COG1173 Cluster_699114 V1202349 S VRR-NUC domain protein 122HE Cluster_644719 V1202351 YGIQ C upf0313 protein COG1032 Cluster_245138 V1202352 XYLS map00052,map00500,map01100 G hydrolase, family 31 COG1501 Cluster_245139 V1202353 U, W Pfam:YadA COG5295 Cluster_245140 V1202354 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_702202 V1202359 S conserved domain protein 11G4D Cluster_396539 V1202360 VEX3 V abc transporter permease protein COG0577 Cluster_401767 V1202361 HSLO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) COG1281 Cluster_363546 V1202364 RSMI G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 Cluster_298170 V1202367 S Family of unknown function (DUF490) 0ZVTR Cluster_534362 V1202368 NRDE map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_458833 V1202369 RPLY map03010 J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) COG1825 Cluster_792881 V1202370 YIDD S Could be involved in insertion of integral membrane proteins into the membrane (By similarity) COG0759 Cluster_515112 V1202371 S NA 0YDZN Cluster_378814 V1202373 NRDF map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_777245 V1202375 GCVR T UPF0237 protein COG3830 Cluster_261659 V1202376 FTSK D cell division protein FtsK COG1674 Cluster_321376 V1202379 E amino acid COG0531 Cluster_603111 V1202380 S NA 11W9N Cluster_292639 V1202383 SSCG_03340 S Membrane COG2860 Cluster_444927 V1202384 UDP map00240,map00983,map01100 F Uridine phosphorylase COG2820 Cluster_458834 V1202387 HRCA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) COG1420 Cluster_284470 V1202389 MENA map00130,map01100,map01110 H 1,4-dihydroxy-2-naphthoate octaprenyltransferase COG1575 Cluster_276383 V1202391 S NA 0YZ82 Cluster_335027 V1202393 MENA map00130,map01100,map01110 H 1,4-dihydroxy-2-naphthoate octaprenyltransferase COG1575 Cluster_412483 V1202394 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_456869 V1202395 S NA 0ZHU9 Cluster_434865 V1202396 DAM map03430 L DNA adenine methylase COG0338 Cluster_283102 V1202397 U, W Pfam:YadA COG5295 Cluster_284471 V1202398 MUTF map02010 V ABC transporter, ATP-binding protein COG1131 Cluster_284472 V1202399 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_350544 V1202400 GLNH map00240,map00983,map01100,map02010 E Extracellular solute-binding protein family 3 COG0834 Cluster_405358 V1202401 RIMP S Required for maturation of 30S ribosomal subunits (By similarity) COG0779 Cluster_285912 V1202403 V efflux transporter, rnd family, mfp subunit COG0845 Cluster_896107 V1202406 DEF J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) COG0242 Cluster_289970 V1202408 S NA 0ZTYV Cluster_352049 V1202410 RECG map03420,map03440 L transcription-repair coupling factor COG1197 Cluster_291281 V1202411 MURD map00471,map00550,map01100 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COG0771 Cluster_294020 V1202412 S NA 0ZHYV Cluster_292640 V1202413 map00550,map01100 M glycosyl transferase, family 51 COG0744 Cluster_292641 V1202414 S NA 101UU Cluster_294021 V1202415 M Cell wall anchor domain protein 11Q8J Cluster_469323 V1202416 YTFP S hi0933 family COG2081 Cluster_554710 V1202417 NDK map00230,map00240,map01100,map01110 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) COG0105 Cluster_504668 V1202419 METI map02010 P ABC transporter, permease COG2011 Cluster_295429 V1202420 KUP P Transport of potassium into the cell (By similarity) COG3158 Cluster_309274 V1202423 V Eco57I restriction-modification methylase COG1002 Cluster_370321 V1202426 S NA 10255 Cluster_652837 V1202427 V FtsX-like permease family 0ZW5X Cluster_380535 V1202428 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_300814 V1202430 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_734599 V1202433 H Transporter COG2978 Cluster_305158 V1202435 CSN1 L crispr-associated protein COG3513 Cluster_305159 V1202436 U, W Pfam:YadA COG5295 Cluster_306544 V1202437 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_306545 V1202438 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_307857 V1202439 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_737896 V1202440 CSPB K Cold shock protein COG1278 Cluster_576360 V1202441 SCLAV_1560 map02010 P ABC transporter COG1122 Cluster_554711 V1202443 PSSA map00260,map00564,map01100 I cdpdiacylglycerol-serine O-phosphatidyltransferase COG1183 Cluster_773509 V1202444 K Inherit from COG: Transcriptional regulator COG3655 Cluster_714860 V1202445 RPLI map03010 J Binds to the 23S rRNA (By similarity) COG0359 Cluster_312247 V1202446 S Possible hemagglutinin (DUF637) 0Y87V Cluster_414341 V1202447 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_434867 V1202450 T Histidine kinase COG5000 Cluster_332037 V1202451 V ABC, transporter COG1131 Cluster_438962 V1202452 TROB map02010 P (ABC) transporter COG1121 Cluster_724795 V1202453 L dna damage-inducible protein 0ZX1H Cluster_523101 V1202458 SLL0832 S Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) 1222S Cluster_718125 V1202459 YRZL S UPF0297 protein COG4472 Cluster_324515 V1202460 S NA 0YBRU Cluster_324516 V1202461 FADD15 map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG1022 Cluster_327578 V1202465 M Cell wall anchor domain protein 11Q8J Cluster_329075 V1202467 PURF map00230,map00250,map01100,map01110 F glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_773510 V1202468 CZRA K Transcriptional regulator, arsr family COG0640 Cluster_499730 V1202469 RAIA J ribosomal subunit Interface protein COG1544 Cluster_542945 V1202471 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_731347 V1202472 RPST map03010 J Binds directly to 16S ribosomal RNA (By similarity) COG0268 Cluster_333525 V1202473 S Domain of unknown function (DUF1837) 1276T Cluster_335028 V1202474 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_338102 V1202477 NTPC map00190,map00680,map01100 C ATP synthase subunit C COG1527 Cluster_338103 V1202478 S NA 11NI8 Cluster_339540 V1202479 F ATP cone domain COG1328 Cluster_678514 V1202480 YHBY J Rna-binding protein COG1534 Cluster_392940 V1202484 DPPC map02010 P ABC transporter (Permease) COG1173 Cluster_339541 V1202485 FRUA map00051,map01100,map02060 G PTS System COG1445 Cluster_537275 V1202486 S Uncharacterized conserved protein (DUF2304) 124N2 Cluster_340991 V1202487 UVRD map03420,map03430 L ATP-dependent DNA helicase PcrA COG0210 Cluster_342518 V1202490 map00550 M Peptidase S13, D-Ala-D-Ala carboxypeptidase C COG2027 Cluster_610396 V1202491 S mobilization protein 11J0G Cluster_344098 V1202492 S ErfK YbiS YcfS YnhG COG1376 Cluster_417929 V1202496 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG0194 Cluster_345732 V1202497 S Amidohydrolase 3 COG1574 Cluster_373551 V1202501 M NA 0YDBK Cluster_812974 V1202502 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_394746 V1202504 MDLA V Abc transporter COG1132 Cluster_357068 V1202505 NTPF S H -ATPase, subunit H 122TR Cluster_357069 V1202506 TNAA map00350,map00380 E tryptophanase EC 4.1.99.1 COG3033 Cluster_428969 V1202507 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_360405 V1202508 HSDR V Type I Restriction COG0610 Cluster_358745 V1202509 MGTE P magnesium transporter COG2239 Cluster_368608 V1202514 TRMB C Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_509837 V1202516 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_363547 V1202520 map01054 Q synthetase COG1020 Cluster_363548 V1202521 U, W Pfam:YadA COG5295 Cluster_365284 V1202524 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_863693 V1202530 P TrkA-N domain protein COG1226 Cluster_368609 V1202532 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_370322 V1202533 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_370323 V1202534 OPPA E ABC transporter COG0747 Cluster_377036 V1202539 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_452908 V1202541 APT map00230,map01100 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) COG0503 Cluster_551859 V1202545 ADDB L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination COG3857 Cluster_419699 V1202546 HPRK T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) COG1493 Cluster_573135 V1202548 MDH map00620,map00710,map01100,map01120,map02020 C malate dehydrogenase (Oxaloacetate-decarboxylating) COG0281 Cluster_384090 V1202549 S NA 11SQP Cluster_480329 V1202550 RIBH map00740,map01100 H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) COG0054 Cluster_384091 V1202553 L DNA Methylase COG2189 Cluster_427078 V1202554 TIG O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COG0544 Cluster_440929 V1202555 YPDP S Membrane COG1738 Cluster_534363 V1202556 MRAY map00550,map01100 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) COG0472 Cluster_387695 V1202557 S NA 0YG6V Cluster_391129 V1202559 G Aamy_C COG1523 Cluster_440930 V1202563 M Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) COG1807 Cluster_392941 V1202565 UMUC L Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) COG0389 Cluster_392942 V1202567 S S-layer domain protein 11R54 Cluster_392943 V1202568 S NA 101UU Cluster_534364 V1202570 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_537276 V1202572 YAAK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) COG0718 Cluster_396540 V1202573 BMUL_2277 L DNA Methylase COG1475 Cluster_509838 V1202574 TRMB S Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_398263 V1202576 S copper amine 0XP8R Cluster_460884 V1202577 S S-layer homology domain 11IK1 Cluster_708387 V1202579 YCGA S c4-dicarboxylate anaerobic carrier COG1288 Cluster_636818 V1202580 ARCC map00230,map00330,map00910,map01120 E carbamate kinase COG0549 Cluster_399981 V1202581 U, W Pfam:YadA COG5295 Cluster_769865 V1202582 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_401769 V1202585 TNPB L transposase COG0675 Cluster_492082 V1202586 PUUR K Transcriptional regulator COG1396 Cluster_403549 V1202588 SAGG map02010 V ABC transporter, ATP-binding protein COG1131 Cluster_699115 V1202590 SP_0058 K GntR family transcriptional regulator COG2188 Cluster_405359 V1202591 GPMI map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0696 Cluster_636820 V1202592 RPST map03010 J Binds directly to 16S ribosomal RNA (By similarity) COG0268 Cluster_407047 V1202594 SUGC map02010 G (ABC) transporter COG3839 Cluster_883947 V1202596 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_407048 V1202597 V ABC transporter ATP-binding COG1132 Cluster_839816 V1202598 MACB V ABC transporter COG1136 Cluster_407049 V1202599 UVRA2 map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_408803 V1202600 M hemolysin erythrocyte lysis protein 2 COG1208 Cluster_812977 V1202603 S NA 1262Z Cluster_414342 V1202604 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_414343 V1202606 S NA 0ZTYV Cluster_554712 V1202607 TRMFO J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) COG1206 Cluster_416125 V1202608 U, W Pfam:YadA COG5295 Cluster_800722 V1202610 CCA map03013,map03018 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate COG0617 Cluster_423360 V1202615 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_423361 V1202616 S trap transporter, 4tm 12tm fusion protein COG4666 Cluster_523102 V1202617 HGDA map00362,map01100,map01120,map01220 E dehydratase COG1775 Cluster_507241 V1202619 MIND D site-determining protein COG2894 Cluster_656965 V1202621 RPLU map03010 J This protein binds to 23S rRNA in the presence of protein L20 (By similarity) COG0261 Cluster_425141 V1202624 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_792882 V1202625 S kila-n, DNA-binding domain 0XPNQ Cluster_425142 V1202627 F Permease family COG2233 Cluster_504669 V1202629 S NA 0YVMU Cluster_507242 V1202631 DNAQ map03022,map03420 L helicase COG1199 Cluster_425143 V1202632 U, W Pfam:HIM COG5295 Cluster_835999 V1202634 RPSU map03010 J 30S ribosomal protein S21 COG0828 Cluster_427079 V1202635 ARCC map00230,map00330,map00910,map01120 E carbamate kinase COG0549 Cluster_427080 V1202636 S Acyltransferase family 12D68 Cluster_427081 V1202637 SSTT E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) COG3633 Cluster_427082 V1202638 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_430935 V1202641 YDBI S Membrane COG0628 Cluster_430936 V1202642 ADK map00230,map00240,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_430937 V1202643 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_430938 V1202645 S NA 0YG6V Cluster_432951 V1202647 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_432952 V1202648 SASC S surface protein 11FPX Cluster_585891 V1202650 S cyclase, family COG1878 Cluster_582688 V1202651 L topoisomerase IV, A subunit COG0188 Cluster_434868 V1202654 S NA 0YZ82 Cluster_436912 V1202655 MODC map02010 P ABC transporter COG1118 Cluster_436913 V1202657 PG0188 S BNR Asp-box repeat protein 11U9Y Cluster_458835 V1202659 S Putative cell wall binding repeat 0YEGX Cluster_499731 V1202661 S NA 0YEF7 Cluster_440931 V1202664 Q amino acid adenylation 0XPD8 Cluster_548956 V1202668 V ABC transporter transmembrane region COG1132 Cluster_442946 V1202670 S NA 0YG6V Cluster_442947 V1202674 Q Condensation domain 0XPD8 Cluster_780938 V1202676 TRPH S PHP domain protein COG0613 Cluster_444928 V1202677 LYTC M hydrolase, family 25 COG3757 Cluster_737897 V1202678 S NA 12BS1 Cluster_566843 V1202679 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_769866 V1202680 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_859302 V1202681 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_512416 V1202682 S Membrane protein of unknown function 0ZIET Cluster_448982 V1202689 U, W Pfam:YadA COG5295 Cluster_625270 V1202690 S NA 0Y87T Cluster_448983 V1202691 S NA 127I3 Cluster_566844 V1202693 GLYQ map00970 J glycyl-tRNA synthetase, alpha subunit COG0752 Cluster_751423 V1202696 YDCK S acetyltransferase YdcK 175BH@proNOG Cluster_452910 V1202701 S NA 0YIZN Cluster_705261 V1202703 K Transcriptional regulator, arsr family 121UH Cluster_452911 V1202704 TRAN S Conjugative transposon TraN protein 0XNQ2 Cluster_454934 V1202705 U, W surface protein COG5295 Cluster_454935 V1202707 PROC map00330,map01100,map01110,map01230 E pyrroline-5-carboxylate reductase COG0345 Cluster_900354 V1202709 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_456870 V1202710 YFJK L domain protein COG1204 Cluster_456871 V1202712 GALU map00040,map00052,map00500,map00520,map01100,map01110 M UTP-glucose-1-phosphate uridylyltransferase COG1210 Cluster_456872 V1202713 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_458836 V1202715 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_731349 V1202717 L Recombinase COG1961 Cluster_502278 V1202719 RPLY map03010 J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) COG1825 Cluster_460885 V1202720 P Spermidine putrescine-binding protein COG1840 Cluster_460886 V1202721 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_737898 V1202723 OPPD map02010 E, P ABC transporter COG0444 Cluster_477906 V1202729 AQPZ G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) COG0580 Cluster_528802 V1202731 GLNE O, T Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) COG1391 Cluster_721435 V1202735 TYRA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydrogenase COG0287 Cluster_467174 V1202736 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_467175 V1202738 S NA 12B21 Cluster_773512 V1202744 S Prolyl oligopeptidase family COG1073 Cluster_469325 V1202746 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_762106 V1202749 YAAA S s4 domain protein COG2501 Cluster_497080 V1202750 PPC map00620,map00680,map00710,map00720,map01100,map01120 C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) COG2352 Cluster_625272 V1202752 TRKA P potassium transporter peripheral membrane COG0569 Cluster_471459 V1202753 L Helicase COG4581 Cluster_471460 V1202754 UBIE map00340,map00350,map00624,map01120 Q methyltransferase COG0500 Cluster_816771 V1202755 map00260,map00290,map01100,map01110,map01230 E Threonine dehydratase COG1171 Cluster_517799 V1202757 RIBH map00740,map01100 H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) COG0054 Cluster_683061 V1202758 FLD C Flavodoxin COG0716 Cluster_484960 V1202759 NRDR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) COG1327 Cluster_473574 V1202760 PYRF map00240,map01100 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) COG0284 Cluster_475704 V1202765 P TonB dependent receptor COG4771 Cluster_475705 V1202766 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_475706 V1202768 P tonB-dependent Receptor COG4206 Cluster_520340 V1202770 YXIO G major facilitator superfamily COG2270 Cluster_640845 V1202771 AZLD E branched-chain amino acid COG1687 Cluster_812979 V1202772 S ATPase (AAA COG1373 Cluster_867738 V1202778 GRDI S reductase 0XPPI Cluster_482640 V1202781 S NA 11FZK Cluster_554713 V1202783 GLTA map00250,map00910,map01100,map01110,map01120,map01230 E Glutamate synthase COG0543 Cluster_551860 V1202786 map02010 E PBPb COG0834 Cluster_484962 V1202787 S Conserved Protein COG4866 Cluster_487238 V1202788 B565_1256 S NA 11JBM Cluster_499732 V1202790 S small multi-drug export COG2426 Cluster_487239 V1202792 PEPP E Xaa-Pro aminopeptidase COG0006 Cluster_487240 V1202793 map02010 V ABC transporter COG1131 Cluster_489591 V1202797 DEDA P SNARE associated Golgi COG0586 Cluster_489592 V1202798 DUSB J Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_492086 V1202802 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_492087 V1202803 DCK map00230,map00240,map01100 F deoxynucleoside kinase COG1428 Cluster_579451 V1202804 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G Phosphohexokinase COG0205 Cluster_492089 V1202806 PPDK map00620,map00710,map01100,map01120 G Pyruvate phosphate dikinase COG0574 Cluster_492090 V1202807 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_492091 V1202809 RPSD map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) COG0522 Cluster_492092 V1202813 S S-layer domain protein 11R54 Cluster_492093 V1202814 Q amino acid adenylation domain protein COG1020 Cluster_809001 V1202815 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_718128 V1202818 S NA 0YSBG Cluster_780940 V1202820 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_497082 V1202822 map03440 K Transcriptional regulator COG2865 Cluster_674055 V1202824 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_863696 V1202828 S membrAne 11GVZ Cluster_499733 V1202830 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_499734 V1202831 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_499735 V1202832 S trap transporter, 4tm 12tm fusion protein COG4666 Cluster_499736 V1202833 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_589191 V1202837 S NA 0YPTE Cluster_502280 V1202839 PHND map02010 P Phosphonate ABC transporter, periplasmic COG3221 Cluster_502281 V1202840 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_504670 V1202842 U, W Pfam:YadA COG5295 Cluster_548957 V1202843 FTSK D cell division protein FtsK COG1674 Cluster_504671 V1202844 ELI_3039 K RNA Polymerase 1261F Cluster_610398 V1202846 YUFP S inner-membrane translocator COG4603 Cluster_504672 V1202849 S SusD family 0XPTK Cluster_507243 V1202852 OPPA E ABC transporter COG0747 Cluster_507244 V1202855 HSDS V restriction modification system DNA specificity domain COG0732 Cluster_582689 V1202859 S Membrane COG4330 Cluster_582690 V1202860 LACZ map00040,map00052,map00500,map00511,map00531,map00600,map00860,map00944,map00983,map01100,map04142 G beta-galactosidase COG3250 Cluster_714863 V1202861 GLNQ E ABC transporter, ATP-binding protein COG1126 Cluster_692031 V1202863 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_512417 V1202864 S conserved domain protein 11Q3F Cluster_589192 V1202865 S NA 0ZHU9 Cluster_687454 V1202866 S NA 0ZHU9 Cluster_512418 V1202874 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_515114 V1202875 NNRE G Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity) COG0062 Cluster_621475 V1202880 S NA 102R7 Cluster_773513 V1202883 YOCS S Bile acid COG0385 Cluster_517800 V1202884 S Protein of unknown function DUF58 COG1721 Cluster_520341 V1202889 ELI_3039 K RNA Polymerase 1261F Cluster_517802 V1202890 TRMK S SAM-dependent methyltransferase COG2384 Cluster_540077 V1202892 GMK2 map00230,map01100 F Guanylate kinase COG0194 Cluster_520342 V1202894 S NA 0YG6V Cluster_520343 V1202895 L RecA-family ATPase COG3598 Cluster_523103 V1202897 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_551861 V1202898 YITW O fes assembly suf system protein COG2151 Cluster_526034 V1202901 AROA map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate synthase COG0128 Cluster_724797 V1202902 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_526035 V1202905 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_528803 V1202906 S Inherit from NOG: domain protein 0XXVB Cluster_531589 V1202907 S Protein of unknown function (DUF3021) 123B1 Cluster_625273 V1202909 C FMN-binding domain protein COG3976 Cluster_908866 V1202910 VANR T response regulator COG0745 Cluster_534367 V1202919 S S-adenosylmethionine-dependent methyltransferase COG1092 Cluster_592559 V1202920 BCRA map02010 V ABC transporter COG1131 Cluster_534368 V1202921 S Domain of unknown function DUF87 0ZJHN Cluster_596028 V1202923 K GntR Family Transcriptional Regulator COG2188 Cluster_534369 V1202925 V HpaII restriction endonuclease 11A91 Cluster_534370 V1202926 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_773514 V1202928 YBAK S YbaK ebsC protein COG2606 Cluster_534371 V1202929 S Nucleotidyl transferase of unknown function (DUF1814) 0XP6B Cluster_576361 V1202931 ETFA map00910 C Electron transfer flavoprotein COG2025 Cluster_540078 V1202935 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_617812 V1202939 GCVR T UPF0237 protein COG3830 Cluster_540079 V1202941 S NA 0ZHU9 Cluster_540080 V1202942 NIRJ L Pyrroloquinoline quinone biosynthesis protein E COG0535 Cluster_540081 V1202943 S Hydrolase COG0561 Cluster_741350 V1202944 CZCD P cation diffusion facilitator family transporter COG0053 Cluster_542946 V1202946 map01040 E lipolytic protein G-D-S-L family COG2755 Cluster_576362 V1202947 map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) COG1156 Cluster_674056 V1202954 CSAB M Polysaccharide pyruvyl transferase COG2327 Cluster_545896 V1202956 S NA 126MH Cluster_542949 V1202957 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_545897 V1202958 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_542950 V1202960 PEPD E Dipeptidase COG4690 Cluster_545898 V1202962 SPOU J rrna methyltransferase COG0566 Cluster_545900 V1202966 DEOD map00230,map00240,map00270,map00760,map01100,map01110 F purine nucleoside phosphorylase DeoD-type COG0813 Cluster_855395 V1202970 H IA, variant 3 COG0637 Cluster_548958 V1202974 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_551862 V1202976 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_551863 V1202977 YICL E, G Transporter COG0697 Cluster_551864 V1202981 THIW S thiw protein COG4732 Cluster_551865 V1202982 ECFA1 map02010 P ABC transporter COG1122 Cluster_648776 V1202983 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_731350 V1202985 S Membrane 0ZTTH Cluster_714864 V1202986 DNAC L DNA replication protein COG1484 Cluster_610399 V1202988 S phage protein 12CZJ Cluster_566845 V1202989 PRIA map03440 L Primosomal protein n' COG1198 Cluster_557630 V1202991 S S-layer domain protein 0XRBV Cluster_557631 V1202993 PPDK map00620,map00710,map01100,map01120 G pyruvate phosphate dikinase COG0574 Cluster_614025 V1202995 COMEA L Competence protein COG1555 Cluster_560707 V1203004 SERP0565 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_560708 V1203006 BL00983 S Phage Portal Protein 11QNG Cluster_563648 V1203010 G transporter major facilitator family protein COG0477 Cluster_563650 V1203014 PEPP E Xaa-Pro aminopeptidase COG0006 Cluster_566846 V1203018 I protein, conserved in bacteria COG3581 Cluster_566849 V1203021 V abc transporter permease protein 0ZW5X Cluster_569929 V1203025 RECG map03440 L ATP-dependent DNA helicase RecG COG1200 Cluster_569930 V1203026 HTPG map04141,map04151,map04612,map04621,map04626,map04914,map04915,map05200,map05215 O Molecular chaperone. Has ATPase activity (By similarity) COG0326 Cluster_569931 V1203027 RACD map00250,map01054 E aspartate racemase COG1794 Cluster_579452 V1203028 DAPB map00300,map01100,map01110,map01120,map01230 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) COG0289 Cluster_569932 V1203030 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_573140 V1203035 map01054 Q synthetase COG0318 Cluster_573141 V1203036 S NA 0YB9V Cluster_714865 V1203037 S NA 11X94 Cluster_573142 V1203038 S HAD hydrolase, family IA, variant 3 COG1011 Cluster_636822 V1203040 FMT S decarboxylase family COG1611 Cluster_640846 V1203042 NNRD G Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) COG0063 Cluster_576364 V1203043 U, W Pfam:YadA COG5295 Cluster_576365 V1203044 FAS map00061,map00350,map00362,map00627,map00642,map00903,map01100,map01120 I synthase COG4982 Cluster_576366 V1203045 S Cell surface protein 0ZXQA Cluster_579453 V1203046 MT2802 S atpase involved in dna repair 0XNTH Cluster_576367 V1203049 MNTH P H( )-stimulated, divalent metal cation uptake system (By similarity) COG1914 Cluster_579454 V1203050 RNMV L Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) COG1658 Cluster_579455 V1203055 SCPA S Segregation and condensation protein COG1354 Cluster_843919 V1203057 S von Willebrand factor, type A 11H48 Cluster_582692 V1203059 Q Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) COG1020 Cluster_582693 V1203063 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_582694 V1203064 CYSM map00260,map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_582695 V1203065 S NA 0ZX1V Cluster_678515 V1203068 PRIA map03440 L Primosomal protein n' COG1198 Cluster_592560 V1203071 GAP map00010,map01100,map01110,map01120,map01230,map04066,map05010 G Glyceraldehyde-3-phosphate dehydrogenase COG0057 Cluster_589193 V1203073 map00240,map00450 O Pyridine nucleotide-disulphide oxidoreductase COG0492 Cluster_718130 V1203074 HPRA map00260,map00630,map00680,map01100,map01110,map01120 C D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain COG1052 Cluster_589194 V1203076 S Methyltransferase small domain 0XZ2E Cluster_589195 V1203077 U, W Pfam:YadA COG5295 Cluster_592561 V1203078 UVRD map03420,map03430 L ATP-dependent DNA helicase pcra COG0210 Cluster_596029 V1203080 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_610400 V1203082 THIJ map05012 T DJ-1 family COG0693 Cluster_592563 V1203083 S adenosylcobinamide amidohydrolase COG1865 Cluster_896114 V1203088 VICR map02020 T response regulator COG0745 Cluster_596031 V1203090 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_596032 V1203091 BGLA1 map00010 G Glycosyl hydrolase family 1 COG2723 Cluster_596033 V1203093 LGAS_0607 T head morphogenesis protein, SPP1 gp7 COG5585 Cluster_599554 V1203094 S NA 0ZVIT Cluster_599555 V1203100 V abc transporter permease protein COG0577 Cluster_596034 V1203101 S NA 0Y8RQ Cluster_621476 V1203104 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_599556 V1203107 IDSA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_599557 V1203108 BL01171 P hemerythrin hhe cation binding domain protein COG2461 Cluster_632780 V1203110 map02010 P Permease protein COG0609 Cluster_705262 V1203112 P CBS domain COG1253 Cluster_603115 V1203113 map00230,map01100 F adenine phosphoribosyltransferase COG0503 Cluster_606728 V1203116 S NA 0ZHU9 Cluster_606729 V1203119 YHBH J sigma 54 modulation protein ribosomal protein S30EA COG1544 Cluster_610402 V1203121 DNAQ2 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit epsilon COG0847 Cluster_610403 V1203122 LGAS_0606 S Phage Portal Protein 0XP33 Cluster_610404 V1203123 S fibronectin type III domain protein 11FT5 Cluster_610405 V1203124 REX K Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) COG2344 Cluster_614026 V1203125 YKNZ V ABC transporter, permease COG0577 Cluster_614027 V1203127 C Na H antiporter COG1757 Cluster_614028 V1203131 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_610406 V1203133 S AP2 domain 123DH Cluster_610407 V1203134 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_617814 V1203137 GG9_0942 L Transposase COG2801 Cluster_617816 V1203139 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_796863 V1203140 S hi0933 family COG2081 Cluster_621478 V1203146 S pathogenesis 0XR1H Cluster_652841 V1203147 S amidinotransferase COG4874 Cluster_644720 V1203150 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_661202 V1203153 map03070 S NA 122A7 Cluster_656966 V1203157 PANF H Sodium pantothenate symporter COG4145 Cluster_628986 V1203158 E, T ABC, transporter COG0834 Cluster_751424 V1203169 YKUD M ErfK ybiS ycfS ynhG family protein COG1376 Cluster_636825 V1203170 S NA 11YG8 Cluster_636826 V1203171 PPDK map00620,map00680,map00710,map00720,map01100,map01120 G Pyruvate phosphate dikinase COG0574 Cluster_674058 V1203174 V abc transporter permease protein COG0577 Cluster_809004 V1203175 S NA 0Z7BP Cluster_692033 V1203176 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_636828 V1203178 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG2812 Cluster_648777 V1203179 L Primosomal protein, DnaI COG1484 Cluster_640847 V1203180 M Choline kinase COG4750 Cluster_883951 V1203181 DCM map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_669684 V1203182 OPPB E, P Oligopeptide ABC transporter, permease protein AppB COG0601 Cluster_636829 V1203183 S Inherit from COG: leucine Rich Repeat COG4886 Cluster_640848 V1203184 L Inherit from COG: DNA Methylase COG0827 Cluster_640849 V1203185 S Pfam:DUF2081 COG1479 Cluster_640850 V1203186 YBHK S UPF0052 protein COG0391 Cluster_644722 V1203190 PILE S TM2 domain containing protein COG2314 Cluster_644724 V1203192 L Resolvase, N terminal domain 123HQ Cluster_644725 V1203195 HLYX P CBS domain protein COG1253 Cluster_648779 V1203197 YBHK S UPF0052 protein COG0391 Cluster_648780 V1203200 S NA 11U85 Cluster_652843 V1203202 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_652844 V1203204 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_652845 V1203205 MURG map00550,map01100,map04112 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) COG0707 Cluster_652846 V1203207 PBP2A map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_652847 V1203209 S NA 0YG6V Cluster_661204 V1203216 S NA 11YT1 Cluster_661205 V1203217 S NA 11NI8 Cluster_661208 V1203220 S Phage portal protein COG4695 Cluster_665368 V1203229 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_777251 V1203230 S NA 11UHB Cluster_665369 V1203233 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_665370 V1203237 NORM V Mate efflux family protein COG0534 Cluster_665371 V1203239 map00680 C Na H antiporter COG1757 Cluster_669685 V1203240 L site-specific recombinase COG1961 Cluster_669687 V1203244 NUSA K Transcription elongation factor NusA COG0195 Cluster_674060 V1203248 PYRK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) COG0543 Cluster_678517 V1203253 CYSK map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_678518 V1203254 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_678519 V1203255 M NA 0YDBK Cluster_714866 V1203258 METE map00270,map00450,map01100,map01110,map01230 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) COG0620 Cluster_683065 V1203262 DEOA map00240,map00983,map01100,map05219 F The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) COG0213 Cluster_687457 V1203263 YTBE map00051,map00363,map00591,map00625,map00650,map01100,map01120 C reductase COG0656 Cluster_687459 V1203268 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (alpha subunit) COG0587 Cluster_687460 V1203269 RPLI map03010 J Binds to the 23S rRNA (By similarity) COG0359 Cluster_724800 V1203276 S NA 0YMVP Cluster_168521 V1203277 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_25113 V1203278 S Lipase (class 3) 0ZJUJ Cluster_157807 V1203280 AMET_0436 S Bacteriophage protein COG3299 Cluster_566850 V1203281 map03060,map03070 U Membrane protein insertase, YidC Oxa1 family COG0706 Cluster_348927 V1203284 map04112 M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) COG1589 Cluster_298172 V1203285 AGAC map00052,map02060 G PTS System COG3715 Cluster_259036 V1203286 MURQ map00520 G Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate COG2103 Cluster_360406 V1203288 I PAP2 Family COG0671 Cluster_126794 V1203291 YAGE E amino acid COG0531 Cluster_469327 V1203292 K Transcriptional regulator CarD family 11TV7 Cluster_828413 V1203296 L Inherit from COG: transposase COG2826 Cluster_10191 V1203297 SCLAV_4759 L DNA helicase COG1112 Cluster_170317 V1203298 YCJV map02010 G Abc transporter COG3839 Cluster_1117 V1203299 S Transglycosylase SLT domain COG5283 Cluster_66288 V1203300 YLOV S dak2 domain fusion protein ylov COG1461 Cluster_287318 V1203302 ERIC P Chloride channel COG0038 Cluster_173707 V1203303 M licD family COG3475 Cluster_131119 V1203304 V Restriction modification system DNA (Specificity COG0732 Cluster_25208 V1203306 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_355381 V1203307 S domain protein 0XNZW Cluster_47109 V1203308 YFMR S abc transporter COG0488 Cluster_139775 V1203309 SP_0145 G Major Facilitator COG0477 Cluster_20613 V1203310 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_174514 V1203311 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_403550 V1203312 YHGE S domain protein COG1511 Cluster_285913 V1203313 YBJB S integral membrane protein COG4858 Cluster_264338 V1203314 PARB K parb-like partition protein COG1475 Cluster_264339 V1203315 NOC K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) COG1475 Cluster_448984 V1203316 S Colicin v production protein 0Y5GJ Cluster_200879 V1203317 YLEB S Outer surface protein COG3589 Cluster_465093 V1203318 L Site-specific recombinase COG1961 Cluster_203963 V1203319 LDCA V peptidase U61 LD-carboxypeptidase A COG1619 Cluster_186473 V1203321 YCHF J gtp-binding protein COG0012 Cluster_108790 V1203322 YFNA E amino acid COG0531 Cluster_355382 V1203323 COBQ S Glutamine amidotransferase COG3442 Cluster_292642 V1203324 THID map00730,map01100 H phosphomethylpyrimidine kinase COG0351 Cluster_20925 V1203325 LEVR K Transcriptional COG3933 Cluster_450957 V1203326 LDH map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120 C L-Lactate dehydrogenase COG0039 Cluster_8197 V1203327 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_177781 V1203328 LGAS_0572 L Integrase COG0582 Cluster_47110 V1203329 BGLF map00500,map02060 G pts system COG2190 Cluster_237282 V1203330 S NA 11GVV Cluster_245141 V1203331 K Transcriptional regulator COG0583 Cluster_250302 V1203332 PEPR map00330 E Releases the N-terminal proline from various substrates (By similarity) 0ZVHU Cluster_234887 V1203333 BSH map00120,map00121,map01100 M Choloylglycine hydrolase COG3049 Cluster_456873 V1203334 S Glycine sarcosine betaine reductase 0ZWHF Cluster_125403 V1203335 E Dipeptidase COG0624 Cluster_93744 V1203336 SCRB map00052,map00500,map01100 G sucrose-6-phosphate hydrolase COG1621 Cluster_769868 V1203338 WECD K acetyltransferase COG0454 Cluster_448985 V1203339 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_239874 V1203341 MLEP3 S auxin efflux carrier COG0679 Cluster_174515 V1203342 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_22437 V1203343 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_438963 V1203344 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_348928 V1203345 T Histidine kinase 0XNMH Cluster_315318 V1203346 COAX map00770,map01100 K Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) COG1521 Cluster_262956 V1203347 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_6130 V1203348 S NA 101UU Cluster_40862 V1203350 DPPD map02010 S ABC transporter COG1123 Cluster_175328 V1203351 ATOB map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map02020 I acetyl-coa acetyltransferase COG0183 Cluster_19106 V1203352 PEPN map00480,map01100 E aminopeptidase N COG0308 Cluster_45762 V1203353 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_171141 V1203355 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_145710 V1203356 GLYA map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01230 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) COG0112 Cluster_31186 V1203357 GALA map00052,map00561,map00600,map00603 G alpha-galactosidase COG3345 Cluster_454936 V1203358 K Transcriptional regulator COG1309 Cluster_227753 V1203359 PANE1 map00770,map01100,map01110 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) COG1893 Cluster_110050 V1203360 D DivIVA protein COG3599 Cluster_444929 V1203361 NQR map00051,map00363,map00591,map00625,map00650,map01100,map01120 S Nadph-dependent fmn reductase COG0431 Cluster_122148 V1203362 GSHR3 map00010,map00020,map00260,map00280,map00480,map00620,map01100,map01110,map01120 C reductase COG1249 Cluster_189012 V1203366 CAS2 L CRISPR-associated protein cas2 11VHR Cluster_137469 V1203367 COMFA L Competence protein COG4098 Cluster_366990 V1203368 L Inherit from COG: Competence protein COG1040 Cluster_110051 V1203369 YIFK E amino acid COG1113 Cluster_106409 V1203370 E amino acid COG0531 Cluster_33119 V1203372 LGAS_0626 S NA 121JZ Cluster_432953 V1203373 LGAS_0625 S Uncharacterized protein conserved in bacteria (DUF2313) 127C4 Cluster_168522 V1203374 XKDT S baseplate J family protein COG3299 Cluster_582697 V1203375 LGAS_0623 S phage protein 1218T Cluster_603116 V1203376 LGAS_0622 S Protein of unknown function (DUF2577) 0XYND Cluster_80966 V1203377 ASPC map00250,map00290,map01100,map01110,map01210,map01230 E Aminotransferase COG0436 Cluster_50957 V1203378 map02020 V ABC transporter, permease COG0577 Cluster_98432 V1203379 E amino acid COG0531 Cluster_340992 V1203380 map02010 V ABC-2 type transporter 1282E Cluster_196955 V1203381 TGT J Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COG0343 Cluster_377037 V1203382 S NA 0XV6C Cluster_166139 V1203383 NAPA P Sodium hydrogen exchanger COG0475 Cluster_407050 V1203385 S integral membrane protein COG5523 Cluster_347301 V1203386 VICR map02020 T response regulator COG0745 Cluster_333526 V1203387 ARAD map00040,map00053,map01100,map01120 G L-ribulose-5-phosphate 4-epimerase COG0235 Cluster_131889 V1203388 HFLX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COG2262 Cluster_242521 V1203389 CYSK map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_12526 V1203390 M Cell surface protein 11GRZ Cluster_477909 V1203391 YJEM E Inner membrane transporter yjeM 174IZ@proNOG Cluster_139776 V1203392 S tail tape measure protein COG5412 Cluster_789094 V1203394 S Tail tape measure protein, TP901 family COG5280 Cluster_548959 V1203395 SP_1924 S NA 0Y6AG Cluster_804974 V1203396 S Single-strand binding protein 11IEM Cluster_163677 V1203397 S NA 11R20 Cluster_573144 V1203399 S NA 12BNJ Cluster_16214 V1203401 V abc transporter permease protein COG0577 Cluster_64838 V1203402 LACE map00052,map01100,map02060 G pts system, lactose-specific COG1455 Cluster_463006 V1203403 LUXS map00270,map05111 T Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) COG1854 Cluster_153647 V1203404 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_299452 V1203405 S osta family 0XUST Cluster_399982 V1203407 YGAC J UPF0374 protein COG3557 Cluster_108791 V1203408 RUMA map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_31082 V1203409 RTPR map00230,map00240,map01100 F Ribonucleoside-triphosphate reductase COG0209 Cluster_448986 V1203410 YVQK S adenosyltransferase COG2096 Cluster_648781 V1203411 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_169454 V1203412 M teichoic acid biosynthesis COG1887 Cluster_99481 V1203413 WZX M polysaccharide biosynthesis protein COG2244 Cluster_350545 V1203414 CPSM map00051 M Polysaccharide biosynthesis protein COG3774 Cluster_110734 V1203415 ENC_19000 map00010 G glycoside hydrolase, family 1 COG2723 Cluster_100555 V1203416 PTCC map00052,map01100,map02060 G pts system COG1455 Cluster_162879 V1203418 YJDB S NA 128F1 Cluster_207226 V1203419 CYDB map00190,map01100,map02020 C cytochrome d ubiquinol oxidase, subunit ii COG1294 Cluster_186474 V1203420 S Filamentation induced by cAMP protein fic COG3177 Cluster_599558 V1203421 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_95202 V1203422 MPTP_1202 S Lysm domain protein 11U6T Cluster_256427 V1203423 PSAA map02010 P ABC transporter COG0803 Cluster_526036 V1203425 AMAA map00360 E Peptidase dimerisation domain COG1473 Cluster_294022 V1203426 LGG_00492 S hydrolase COG0561 Cluster_573145 V1203427 CRCB D Protein CrcB homolog COG0239 Cluster_150442 V1203428 LIAG map02020 S Inherit from NOG: Membrane 0XV6C Cluster_731352 V1203430 GLPF G Major Intrinsic Protein COG0580 Cluster_120613 V1203431 V abc transporter COG1132 Cluster_152042 V1203432 CARA map00240,map00250,map01100 F carbamoyl-phosphate synthetase glutamine chain COG0505 Cluster_63180 V1203433 S Cell Division Protein 0ZINK Cluster_60958 V1203434 CYDC map02010 V (ABC) transporter COG4987 Cluster_182075 V1203435 LGAS_0572 L Integrase COG0582 Cluster_507246 V1203436 LGAS_0574 S Domain of unknown function (DUF955) 0XW04 Cluster_606731 V1203437 DICA K Transcriptional regulator COG1396 Cluster_350546 V1203438 YVOA K (GntR family) (Transcriptional regulator COG2188 Cluster_156095 V1203439 BL01171 P hemerythrin hhe cation binding domain protein COG2461 Cluster_800725 V1203440 SPOU J rrna methyltransferase COG0566 Cluster_186475 V1203441 M Cell surface protein 11GRZ Cluster_75786 V1203442 map02010 V ABC transporter COG1132 Cluster_120614 V1203443 PEPC E aminopeptidase c COG3579 Cluster_592564 V1203444 YTFP S hi0933 family COG2081 Cluster_33876 V1203445 map02020,map02030 S Methyl-accepting chemotaxis protein (MCP) signalling domain COG0840 Cluster_109424 V1203446 PTS36C map00052,map01100,map02060 G PTS system, galactitol-specific IIc component COG3775 Cluster_85114 V1203447 S NA 11VH8 Cluster_360407 V1203448 K Transcriptional regulator COG1737 Cluster_158687 V1203449 SP_0298 S ATPase (AAA COG1373 Cluster_148818 V1203451 DLTB map05150 M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_50761 V1203452 FLGJ N, U flagellar rod assembly protein muramidase flgj COG1705 Cluster_104590 V1203453 LYSA2 M Glyco_25 COG3757 Cluster_126096 V1203454 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_436914 V1203455 J acetyltransferase, (GNAT) family COG1670 Cluster_408804 V1203456 YJBF S SNARE-like domain protein COG0398 Cluster_309275 V1203457 TERC P membrane protein, TerC COG0861 Cluster_11367 V1203458 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit alpha COG0587 Cluster_661212 V1203459 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_287319 V1203460 VEX3 V abc transporter permease protein COG0577 Cluster_319891 V1203461 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_139777 V1203462 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_385849 V1203463 FABG map00061,map00780,map01040,map01100 I reductase 0XNW1 Cluster_87684 V1203464 GNTK map00030,map01100,map01110,map01120 G Gluconate kinase COG1070 Cluster_176121 V1203465 LYTR K TRANSCRIPTIONal COG1316 Cluster_153648 V1203466 G Major Facilitator COG0477 Cluster_542951 V1203467 LGAS_0618 S XkdN-like protein 11VQZ Cluster_497084 V1203468 LGAS_0617 S XkdM protein, phage-like element PBSX 11FZB Cluster_515115 V1203469 RMAI K Transcriptional regulator 0XUB6 Cluster_47492 V1203470 PTBA map02060 G pts system COG2190 Cluster_576368 V1203471 PLSC2 map00561,map00564,map01100 I Acyl-transferase COG0204 Cluster_321377 V1203472 MTSC map02010 P ABC transporter COG1108 Cluster_96285 V1203473 map00052,map01100,map02060 G PTS system, galactitol-specific IIc component COG3775 Cluster_614029 V1203475 YHEA S UPF0342 protein COG3679 Cluster_416127 V1203476 S NA 0YNCM Cluster_243868 V1203477 MANN map00051,map00520,map01100,map02060 G PTS system mannose fructose sorbose family transporter subunit IID COG3716 Cluster_216121 V1203478 MANX map00051,map00520,map01100,map02060 G pts system COG3444 Cluster_300815 V1203485 S Protein of unknown function (DUF1071) 12192 Cluster_345733 V1203487 LDH map00010,map00051,map00270,map00363,map00591,map00620,map00625,map00640,map00650,map01100,map01110,map01120 C Dehydrogenase COG0039 Cluster_125404 V1203488 ASPC map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aspartate aminotransferase COG0436 Cluster_171963 V1203491 S phage protein 0XQDU Cluster_164485 V1203492 AGAS map00250,map00520,map01100,map01110 M isomerase COG2222 Cluster_489593 V1203493 RLMH S Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) COG1576 Cluster_74482 V1203494 YBEC E amino acid COG0531 Cluster_318415 V1203495 SP_1071 S abc transporter atp-binding protein COG1101 Cluster_606732 V1203496 CKL_1914 K Transcriptional regulator 0XUC3 Cluster_163678 V1203501 S von Willebrand factor type 11R5D Cluster_25703 V1203502 M Inherit from COG: peptidase' 0XPHJ Cluster_617817 V1203503 S NA 0ZH06 Cluster_296769 V1203504 SA0315 K SIR2 family COG0846 Cluster_181152 V1203505 YBIR P transporter COG0471 Cluster_38674 V1203506 M Sulfatase COG1368 Cluster_563651 V1203507 SP_0889 S Death-On-Curing Family COG3654 Cluster_640852 V1203509 S Uncharacterised protein family (UPF0150) 101HY Cluster_347303 V1203510 S NA 11SQP Cluster_120615 V1203512 GLYQS map00970 J Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) COG0423 Cluster_245142 V1203513 CORA P transporter COG0598 Cluster_285914 V1203514 L NA 121AE Cluster_507247 V1203515 AMAA map00360 E Peptidase dimerisation domain COG1473 Cluster_62899 V1203516 NPLT map00500,map01100,map04973 G alpha amylase, catalytic region COG0366 Cluster_347304 V1203517 YFNB map00361,map00625,map01100,map01120 S Hydrolase COG1011 Cluster_283103 V1203518 SP_0742 S degv family COG1307 Cluster_152872 V1203521 S mobA MobL 17C5P@proNOG Cluster_299453 V1203523 PHNB map02010 P phosphonate abc transporter COG3639 Cluster_256428 V1203524 G Major Facilitator superfamily 0XT9M Cluster_243869 V1203526 OCAR_6158 L Terminase, large subunit COG4626 Cluster_863700 V1203527 S NA 127RR Cluster_186476 V1203528 S Archaeal ATPase 0ZW9J Cluster_167673 V1203529 LGAS_0607 T head morphogenesis protein, SPP1 gp7 COG5585 Cluster_766088 V1203530 SP_0677 S Bacterial protein of unknown function (DUF910) COG4483 Cluster_332038 V1203531 S Inherit from COG: Hemerythrin HHE cation binding domain protein COG2461 Cluster_205036 V1203532 RFBD map00521,map00523,map01100,map01110 M Dtdp-4-dehydrorhamnose reductase COG1091 Cluster_86377 V1203533 YFNA E amino acid COG0531 Cluster_391131 V1203535 K HTH_XRE COG1974 Cluster_632785 V1203537 Y2191 K Antirepressor COG3617 Cluster_306546 V1203538 YBJI S Hydrolase COG0561 Cluster_257709 V1203539 S NA 11GVV Cluster_104591 V1203540 CLCAR_1091 T Histidine kinase COG0642 Cluster_434870 V1203541 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0470 Cluster_196956 V1203542 V Beta-lactamase class C related penicillin binding protein COG1680 Cluster_361976 V1203543 RNC map03008,map05205 K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) COG0571 Cluster_206117 V1203544 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_231251 V1203545 HPRK T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) COG1493 Cluster_875769 V1203546 INSI L transposase COG2826 Cluster_50157 V1203547 PORAS_0069 L Transposase (IS4 family 0XT1T Cluster_434871 V1203548 SP_0482 S UPF0397 protein COG4720 Cluster_360408 V1203550 ENC_10390 S Membrane COG3819 Cluster_246470 V1203551 SP_0859 S Membrane COG3817 Cluster_380536 V1203552 PCP O Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) COG2039 Cluster_260337 V1203553 PSTA map02010 P phosphate ABC transporter (Permease COG0581 Cluster_218455 V1203554 PSTC map02010 P phosphate abc transporter COG0573 Cluster_373553 V1203555 K transcriptional regulator 0ZMZA Cluster_333527 V1203556 FAT map00061,map01100 I Acyl-ACP thioesterase COG3884 Cluster_89504 V1203557 GLNPH2 E amino acid ABC transporter COG0834 Cluster_77500 V1203558 map02010 V ABC transporter COG1132 Cluster_566851 V1203560 YSLB S hydrocarbon binding protein 121J8 Cluster_523105 V1203561 K Transcriptional regulator 0XYJE Cluster_287320 V1203562 P Ion channel COG1226 Cluster_170318 V1203563 HPK31 T Histidine kinase COG0642 Cluster_292643 V1203564 K Transcriptional regulator 0Y1S3 Cluster_327579 V1203565 ECSA V abc transporter atp-binding protein COG1131 Cluster_281699 V1203566 YQFL S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) COG1806 Cluster_265665 V1203567 SP_2113 S membrAne COG1284 Cluster_463007 V1203568 S NA 11XM2 Cluster_208348 V1203569 NRNA J phosphoesterase RecJ domain protein COG0618 Cluster_119118 V1203570 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01230 G phosphohexose isomerase COG0166 Cluster_276384 V1203571 map04112 M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) COG1589 Cluster_69603 V1203572 S domain protein 0YF83 Cluster_401770 V1203574 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_105184 V1203575 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_231252 V1203576 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G Phosphohexokinase COG0205 Cluster_344099 V1203578 NPDA map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_178618 V1203579 S NA 0Y3BQ Cluster_40237 V1203580 RECG map03440 L ATP-dependent DNA helicase recG COG1200 Cluster_218456 V1203581 S Protein of unknown function (DUF3137) 11MSU Cluster_27179 V1203582 S Rib/alpha-like repeat 10008 Cluster_132632 V1203584 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_396541 V1203590 YKOE S ABC superfamily ATP binding cassette transporter membrane protein COG4721 Cluster_336563 V1203591 S NA 11VCX Cluster_43488 V1203592 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_30232 V1203593 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_504675 V1203598 RUSA L endodeoxyribonuclease RusA COG4570 Cluster_243870 V1203599 PHND map02010 P phosphonate ABC transporter, periplasmic phosphonate-binding protein COG3221 Cluster_191658 V1203600 LGAS_0610 S Major capsid protein 11IJY Cluster_573147 V1203601 LGAS_0611 S NA 0ZD5C Cluster_603117 V1203602 S NA 0ZA04 Cluster_714867 V1203603 GLYQS map00970 J Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) COG0423 Cluster_87258 V1203604 RV3193C S UPF0182 protein COG1615 Cluster_851604 V1203605 O Matrixin COG5549 Cluster_257710 V1203606 MSCS M mechanosensitive ion channel COG0668 Cluster_358746 V1203607 M ErfK YbiS YcfS YnhG COG1376 Cluster_242522 V1203608 LYSA2 M Glyco_25 COG3757 Cluster_329076 V1203613 S tail component COG4722 Cluster_294023 V1203616 S hydrolase COG0561 Cluster_442948 V1203617 map00350,map00362,map00627,map00642,map00903,map01120 J -acetyltransferase COG1670 Cluster_87685 V1203618 YJEM E Inner membrane transporter yjeM 174IZ@proNOG Cluster_168523 V1203619 L Integrase COG0582 Cluster_648783 V1203620 LGG_00800 S NA 11UDD Cluster_163679 V1203621 TNPB L transposase COG0675 Cluster_708392 V1203622 S integral membrane protein 121K9 Cluster_318416 V1203623 LACR K DeoRC COG1349 Cluster_289971 V1203624 LICT K antiterminator COG3711 Cluster_515116 V1203625 Y1855 P asch domain protein COG4405 Cluster_213812 V1203626 PSTC map02010 P phosphate abc transporter COG0573 Cluster_167674 V1203627 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_216122 V1203628 TRXB map00240,map00450 C ferredoxin--nadp reductase COG0492 Cluster_832085 V1203629 map00362,map00621,map00622,map01100,map01120 S Tautomerase enzyme 0XVB0 Cluster_148076 V1203630 HOM map00260,map00270,map00300,map01100,map01110,map01120,map01230 E homoserine dehydrogenase COG0460 Cluster_387696 V1203631 UNG2 L uracil-dna glycosylase COG1573 Cluster_534373 V1203632 L Nudix family COG0494 Cluster_231253 V1203634 L Site-specific recombinase COG1961 Cluster_357070 V1203636 SRTA M (sortase) family COG3764 Cluster_357071 V1203637 GPMA1 map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0588 Cluster_241152 V1203639 I Diacylglycerol kinase COG1597 Cluster_430939 V1203640 WHIA K May be required for sporulation (By similarity) COG1481 Cluster_119888 V1203641 DNAB L replication initiation and membrane attachment protein COG3611 Cluster_142763 V1203642 PYRB map00240,map00250,map01100 F aspartate transcarbamylase COG0540 Cluster_357072 V1203643 LGAS_0620 S domain protein COG1652 Cluster_57767 V1203645 L helicase COG4646 Cluster_152873 V1203646 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_138232 V1203647 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_332039 V1203649 S NA 0XNUC Cluster_410663 V1203651 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_184674 V1203652 YCEG F aminodeoxychorismate lyase COG1559 Cluster_487241 V1203653 S Nitroreductase 1234Z Cluster_373554 V1203657 AROB map00400,map01100,map01110,map01230 E 3-dehydroquinate synthase COG0703 Cluster_477910 V1203658 AROQ map00400,map01100,map01110,map01230 E Catalyzes a trans-dehydration via an enolate intermediate (By similarity) COG0757 Cluster_576369 V1203659 S NA 122IS Cluster_75467 V1203660 PCCB map00280,map00630,map00640,map00720,map01100,map01120 I carboxyl transferase COG4799 Cluster_515117 V1203661 SCLAV_2624 S NA 0YQAJ Cluster_366991 V1203662 CLPP map04112 O ATP-dependent Clp protease, proteolytic subunit COG0740 Cluster_391132 V1203663 LGAS_0609 S Phage minor structural protein GP20 123J7 Cluster_102793 V1203664 TEH_04440 map00052,map01100,map02060 G PTS system, galactitol-specific IIc component COG3775 Cluster_780943 V1203665 RPOZ map00230,map00240,map01100,map03020 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) COG1758 Cluster_582698 V1203667 S NA 0YIA5 Cluster_403551 V1203668 S Relaxase mobilization nuclease 0Y9PG Cluster_843921 V1203669 RPMG2 map03010 J 50S ribosomal protein L33 COG0267 Cluster_116990 V1203670 MPHA S Aminoglycoside phosphotransferase 0YEJ0 Cluster_279052 V1203672 V Type II site-specific deoxyribonuclease 0ZIH9 Cluster_130331 V1203673 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_176947 V1203674 BL02952 S Membrane COG1434 Cluster_416128 V1203675 BL01877 K Transcriptional regulator COG1309 Cluster_728048 V1203676 YOEB S Addiction module toxin, Txe YoeB family COG4115 Cluster_625275 V1203677 YABA S Involved in initiation control of chromosome replication (By similarity) COG4467 Cluster_275051 V1203678 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0470 Cluster_401771 V1203679 map00230 S relA SpoT domain protein COG2357 Cluster_233685 V1203680 BL00740 K transcriptional regulator 0XR9S Cluster_132633 V1203682 MVAS map00072,map00280,map00650,map00900,map01100,map01110 I Hydroxymethylglutaryl-CoA synthase COG3425 Cluster_741351 V1203684 S NA 0Z7KY Cluster_269730 V1203686 YCSE S hydrolase COG0561 Cluster_140505 V1203687 map03420,map03430 L helicase COG3973 Cluster_809005 V1203688 HSDM V type I restriction-modification system COG0286 Cluster_261663 V1203690 LACX map00010,map01110,map01120 G aldose 1-epimerase COG2017 Cluster_339542 V1203691 TRMD map00900,map01100,map01110 J Specifically methylates guanosine-37 in various tRNAs (By similarity) COG0336 Cluster_382304 V1203693 S tpr repeat-containing protein 11U03 Cluster_434872 V1203694 TRML map04122 J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) COG0219 Cluster_644726 V1203696 MUTS2 map03430 L muts2 protein COG1193 Cluster_264340 V1203697 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_305160 V1203700 SCLAV_2513 map04112 L DNA Methylase COG0863 Cluster_195295 V1203703 HRCA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) COG1420 Cluster_180318 V1203704 PEPP map00310,map00780,map01100 E peptidase M24 COG0006 Cluster_228935 V1203705 MVAD map00900,map01100,map01110 I diphosphomevalonate decarboxylase COG3407 Cluster_332040 V1203706 S SAM-dependent methyltransferase 0YNVR Cluster_780944 V1203707 S Phage minor structural protein, N-terminal domain protein 11ZGW Cluster_714868 V1203708 map00500 S K01838 beta-phosphoglucomutase EC 5.4.2.6 COG0637 Cluster_299454 V1203710 PPNK map00760,map01100 G Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) COG0061 Cluster_452912 V1203712 SP_0161 K, T lytTr DNA-binding domain protein COG3279 Cluster_582699 V1203716 S phage tail component domain protein 11VYN Cluster_313731 V1203718 map02010 P cobalt transport COG0619 Cluster_824563 V1203719 S NA 102MI Cluster_636831 V1203720 S NA 0YFUK Cluster_124741 V1203721 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_408805 V1203722 RECR map03440 L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) COG0353 Cluster_531592 V1203723 MRAZ S Cell division protein mraZ COG2001 Cluster_319892 V1203724 YBBM S ABC transporter, permease COG0390 Cluster_327580 V1203726 YHCG V abc transporter atp-binding protein COG1131 Cluster_416129 V1203727 YGCG S of methanol dehydrogenase type COG1512 Cluster_434873 V1203731 S Inherit from NOG: Methyltransferase 0XSGP Cluster_606733 V1203732 S conserved domain protein 11YGQ Cluster_452914 V1203734 S NA 0Y22Q Cluster_463009 V1203735 S NA 0Z3UR Cluster_563652 V1203737 SP_0064 map00051,map00520,map01100,map02060 G pts system COG2893 Cluster_509840 V1203740 HIT map00230,map00240 F, G histidine triad (hIT) protein COG0537 Cluster_766089 V1203741 S Phage terminase small subunit 11F23 Cluster_473577 V1203743 S NA 129FA Cluster_557632 V1203745 S NA 0ZHU9 Cluster_156946 V1203746 TYPA T gtp-binding protein typa COG1217 Cluster_450958 V1203748 RIML map00350,map00362,map00627,map00642,map00903,map01120 J -acetyltransferase COG1670 Cluster_162880 V1203750 VEX1 V ABC transporter, permease COG0577 Cluster_625276 V1203752 S RelB antitoxin 12546 Cluster_499737 V1203755 S ASCH domain 0Y0UK Cluster_223147 V1203759 PIPD E Dipeptidase COG4690 Cluster_610408 V1203762 RPSA map00900,map01100,map01110,map03010 J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) COG0539 Cluster_190743 V1203763 L Pfam:Transposase_11 0YB49 Cluster_734603 V1203766 ACPP I Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) COG0236 Cluster_324517 V1203767 STP T phosphatase COG0631 Cluster_238599 V1203769 COIA S Competence protein COG4469 Cluster_695829 V1203770 SP_0742 S degv family COG1307 Cluster_836004 V1203773 LOLD V abc transporter atp-binding protein COG1136 Cluster_789096 V1203776 map00010 G Cellulase (glycosyl hydrolase family 5) COG2723 Cluster_201877 V1203777 FLIC map02020,map02040,map04626,map05132,map05134 N Flagellin COG1344 Cluster_711476 V1203779 L DNA packaging protein 123DA Cluster_621480 V1203783 S Archaeal ATPase 0ZW9J Cluster_246471 V1203784 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_232419 V1203785 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_209390 V1203786 PPC map00620,map00680,map00710,map00720,map01100,map01120 C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) COG2352 Cluster_502282 V1203787 LSPA map03060 M, U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) COG0597 Cluster_276385 V1203788 G Major Facilitator COG0477 Cluster_321378 V1203789 PURC map00230,map01100,map01110 F SAICAR synthetase COG0152 Cluster_220802 V1203794 S NA 0YRUB Cluster_345734 V1203795 RECG map03440 L ATP-dependent DNA helicase RecG COG1200 Cluster_855400 V1203796 TRMB C Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_773517 V1203799 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_329077 V1203800 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_274818 V1020201 FABI map00061,map00780,map01100 I Enoyl- acyl-carrier-protein reductase NADH COG0623 Cluster_452514 V1020205 ARGG map00250,map00330,map01100,map01110,map01230 E Citrulline--aspartate ligase COG0137 Cluster_426662 V1020206 RAIA J ribosomal subunit Interface protein COG1544 Cluster_53742 V1020207 S Protein of unknown function (DUF935) COG4383 Cluster_585218 V1020208 RPLL map03010 J Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) COG0222 Cluster_340734 V1020209 GLUC map02010 E ABC transporter COG0765 Cluster_142647 V1020211 FUCA map00511 G Alpha-L-fucosidase COG3669 Cluster_334724 V1020212 S Pfam:DUF88 COG1432 Cluster_264077 V1020213 S Glyoxalase Bleomycin resistance protein (Dioxygenase COG3324 Cluster_545234 V1020217 map02010 E Binding-protein-dependent transport system inner membrane component COG1174 Cluster_234680 V1020218 OPUCC map02010 M Glycine betaine COG1732 Cluster_522522 V1020219 OPUCD map02010 E Glycine betaine carnitine choline COG1174 Cluster_557007 V1020221 RPLK map03010 J This protein binds directly to 23S ribosomal RNA (By similarity) COG0080 Cluster_355030 V1020222 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_460460 V1020223 RPLJ map03010 J ribosomal protein l10 COG0244 Cluster_76355 V1020225 ARC map03050 O ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) COG0464 Cluster_227535 V1020226 S NA 0Y8K6 Cluster_112630 V1020227 LMRA map02010 V ABC transporter COG1132 Cluster_677631 V1020228 DACA map00550,map01100 M carboxypeptidase COG1686 Cluster_274819 V1020232 S NA 0XV8P Cluster_432570 V1020233 L Primosomal protein, DnaI COG1484 Cluster_164343 V1020234 TETB G Major Facilitator 0YSYS Cluster_562956 V1020235 PRE S plasmid recombination enzyme 0XTDI Cluster_639970 V1020236 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_371630 V1020237 YEAZ O Peptidase M22 Glycoprotease COG1214 Cluster_256225 V1020238 GALU map00040,map00052,map00500,map00520,map01100,map01110 M UTP-glucose-1-phosphate uridylyltransferase COG1210 Cluster_686551 V1020240 MT2205 S integral membrane protein COG0762 Cluster_458402 V1020241 SEPF S Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) COG1799 Cluster_313422 V1020245 BUTA map00650 C reductase 0XNW1 Cluster_740678 V1020247 RPME2 map03010 J 50s ribosomal protein l31 COG0254 Cluster_345413 V1020249 UPP map00240,map01100 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) COG0035 Cluster_102707 V1020251 AROP E amino acid COG1113 Cluster_138869 V1020252 O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG0526 Cluster_109316 V1020253 BMUL_4579 G Major Facilitator superfamily 0XT0X Cluster_250067 V1020259 map02010 P ABC transporter COG0395 Cluster_450561 V1020260 HSDS V restriction modification system DNA specificity COG0732 Cluster_219433 V1020261 L recombinase (Phage integrase family) COG0582 Cluster_115427 V1020263 S DivIVA domain repeat protein 11XZ2 Cluster_406701 V1020264 NARJ map00910,map01120,map02020 C nitrate reductase molybdenum cofactor assembly chaperone COG2180 Cluster_146369 V1020268 CSE4 L Crispr-associated protein, cse4 family 0Y6PV Cluster_257468 V1020269 DAGK I Diacylglycerol kinase COG1597 Cluster_835267 V1020270 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_548275 V1020271 AROK map00400,map01100,map01110,map01230 E Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) COG0703 Cluster_108061 V1020272 G Inherit from COG: 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process COG0726 Cluster_131004 V1020275 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_242284 V1020276 YCEA J UPF0176 protein COG1054 Cluster_522523 V1020277 HRPA L ATP-dependent helicase COG1643 Cluster_499196 V1020278 PHOR map02020 T Histidine kinase 0XNMH Cluster_103318 V1020279 NUSA K Transcription elongation factor NusA COG0195 Cluster_430570 V1020285 C Electron transport protein COG1142 Cluster_313423 V1020288 H Involved in biosynthesis of the thiamine precursor thiazole (By similarity) COG1635 Cluster_152732 V1020289 BIOF map00780,map01100 H 8-amino-7-oxononanoate synthase COG0156 Cluster_313424 V1020291 YGDL H uba thif-type nad fad binding protein COG1179 Cluster_460461 V1020292 K RNA polymerase sigma-70 factor COG1595 Cluster_208154 V1020293 NITSA_0073 S transposase 11TFP Cluster_215940 V1020294 AES map00363,map00960,map01120 I alpha beta hydrolase fold-3 domain protein COG0657 Cluster_816046 V1020295 TATA map03060,map03070 U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) 0XUF0 Cluster_203744 V1020296 PAFC K Transcriptional regulator COG2378 Cluster_188002 V1020303 M Glycosyl transferase COG0463 Cluster_428584 V1020304 EFP J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) COG0231 Cluster_406702 V1020306 Y0750 S Conserved Protein COG1479 Cluster_266738 V1020307 ISOVA_0221 V HNH endonuclease 11RVB Cluster_517240 V1020308 RPLI map03010 J Binds to the 23S rRNA (By similarity) COG0359 Cluster_432571 V1020310 PYRE map00240,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_765285 V1020311 FSLA Q IucA IucC family protein COG4264 Cluster_452515 V1020312 ASP23 S alkaline shock protein COG1302 Cluster_496540 V1020314 S NA 0Y5S9 Cluster_70180 V1020315 S Inherit from NOG: antigen PG97 COG4886 Cluster_613261 V1020320 SCLAV_2114 S Protein of unknown function (DUF3499) 11VV4 Cluster_163546 V1020321 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_355031 V1020323 S Leucine rich repeat variant 11WCW Cluster_235869 V1020324 LDH map00010,map00270,map00620,map00640,map01100,map01110,map01120 C L-lactate dehydrogenase COG0039 Cluster_166008 V1020325 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_624489 V1020327 MRPC P Monovalent cation H antiporter subunit C COG1006 Cluster_536668 V1020328 MRPB P monovalent cation H antiporter subunit B COG2111 Cluster_616994 V1020333 S NA 0ZHU9 Cluster_489065 V1020337 FOLK map00790,map01100 H 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase COG0801 Cluster_591849 V1020338 FOLB map00790,map01100 H dihydroneopterin aldolase COG1539 Cluster_292367 V1020339 FOLP map00790,map01100 H dihydropteroate synthase COG0294 Cluster_390810 V1020342 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_331776 V1020343 XYL31A G hydrolase, family 31 COG1501 Cluster_217103 V1020344 BGAA map00052,map00511,map00600,map01100 G Glycosyl hydrolase family 2, sugar binding domain protein COG3250 Cluster_299210 V1020345 RADC L DNA repair protein (RadC COG2003 Cluster_309018 V1020347 YBBP S TIGR00159 family COG1624 Cluster_368314 V1020348 ATOA map00072,map00280,map00627,map00640,map00650,map01100,map01120,map02020 I CoA-transferase subunit B COG2057 Cluster_265423 V1020349 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_446569 V1020350 U Biopolymer transport protein exbD tolR 11JQD Cluster_462583 V1020351 S NA 0Y9ZV Cluster_233493 V1020352 S Methyltransferase domain 10114 Cluster_110593 V1020353 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_59289 V1020354 L UvrD REP helicase COG1074 Cluster_428585 V1020355 TDK map00240,map00983,map01100 F thymidine kinase COG1435 Cluster_253791 V1020356 RBSK map00030 G ribokinase COG0524 Cluster_304886 V1020357 MURI map00471,map01100 M Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) COG0796 Cluster_545235 V1020363 YDHG S Domain of unknown function (DU1801) COG5646 Cluster_482152 V1020364 YQGC S Protein of unknown function (DUF456) COG2839 Cluster_91772 V1020365 S NA 1202C Cluster_482153 V1020367 RECX S regulatory protein RecX 11Y5X Cluster_197698 V1020368 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_668863 V1020369 SCLAV_2230 V ABC, transporter COG0577 Cluster_303367 V1020370 SSCG_04863 V abc transporter COG1136 Cluster_212496 V1020371 LPSA S lipopolysaccharide core biosynthesis protein 0ZUPW Cluster_167499 V1020372 MODB map02010 P molybdate abc transporter COG4149 Cluster_415799 V1020373 MODA map02010 P ABC transporter, periplasmic molybdate-binding protein COG0725 Cluster_198720 V1020374 map00540,map01100 M heptosyltransferase COG0859 Cluster_345414 V1020375 S Zinc finger, swim domain protein COG4279 Cluster_366686 V1020376 ZNUC map02010 P (ABC) transporter COG1121 Cluster_264078 V1020378 UPPP map00550 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) COG1968 Cluster_747347 V1020380 S NA 0ZHU9 Cluster_155965 V1020384 M glycosyltransferase group 1 family protein COG0438 Cluster_847147 V1020386 S NA 0ZHU9 Cluster_135733 V1020393 HUTI map00340,map01100 Q imidazolone-5-propionate hydrolase COG1228 Cluster_228718 V1020395 S Prolyl oligopeptidase family COG1073 Cluster_383739 V1020396 PLAV_1224 S NA 0ZTDK Cluster_187170 V1020397 AGUA map00330,map01100 E Agmatine deiminase COG2957 Cluster_218220 V1020399 NARK P Nitrite extrusion protein COG2223 Cluster_245143 V1203801 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_512419 V1203805 FTHC map00670,map01100 H 5-formyltetrahydrofolate cyclo-ligase COG0212 Cluster_489594 V1203806 S NA 0XTEF Cluster_365285 V1203807 S NA 0YMVP Cluster_731356 V1203808 YICL E, G Transporter COG0697 Cluster_394747 V1203810 S CYTH domain COG4116 Cluster_475709 V1203812 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_333528 V1203815 V ABC transporter COG1136 Cluster_492094 V1203818 YJEE S protein family UPF0079, ATPase COG0802 Cluster_809006 V1203823 P Chloride channel COG0038 Cluster_403552 V1203825 map00380,map01100 D amidohydrolase 2 COG2159 Cluster_392944 V1203829 PGSA map00564,map01100 I cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase COG0558 Cluster_548960 V1203831 S virulence-like protein 0ZW8F Cluster_371937 V1203833 GLNP map02010 E amino acid AbC transporter COG0765 Cluster_309276 V1203834 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_310713 V1203836 S conjugation system ATPase, TraG family 0XSHU Cluster_315319 V1203837 SCLAV_1560 map02010 P ABC transporter COG1122 Cluster_747992 V1203838 S NA 11MJM Cluster_324518 V1203842 S NA 0YBRU Cluster_330475 V1203845 P E1-E2 ATPase COG2217 Cluster_329078 V1203846 FADD15 map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG1022 Cluster_695830 V1203847 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_537278 V1203848 MURE map00300,map00550,map01100 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_699116 V1203849 L Inherit from COG: Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) COG0389 Cluster_891954 V1203850 GTCA S Teichoic acid glycosylation protein COG2246 Cluster_515118 V1203851 SP_0319 G isomerase COG0698 Cluster_377039 V1203854 K Transcriptional regulator COG1609 Cluster_375271 V1203855 THRB map00260,map01100,map01120,map01230 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) COG0083 Cluster_777253 V1203856 S Domain of unknown function (DUF955) 0ZI1U Cluster_606734 V1203857 S NA 121PH Cluster_452915 V1203858 S NA 10WM6 Cluster_361977 V1203859 HSDR V Type I Restriction COG0610 Cluster_665372 V1203864 YRZB S UPF0473 protein COG3906 Cluster_800727 V1203865 S NA 0ZHU9 Cluster_371938 V1203866 FADD15 map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG1022 Cluster_371939 V1203867 S NA 10Z69 Cluster_371940 V1203868 E peptidase COG2195 Cluster_473578 V1203872 QACE S small multi-drug export COG2426 Cluster_724804 V1203873 G major facilitator superfamily 0XNN3 Cluster_557634 V1203874 S NA 11TBU Cluster_828414 V1203877 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_380537 V1203878 S Transglycosylase SLT domain COG5283 Cluster_382305 V1203880 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_896119 V1203881 S NA 11PBT Cluster_836005 V1203884 SCLAV_4542 S UPF0109 protein COG1837 Cluster_913004 V1203885 map02010 S YodA lipocalin-like domain 11KBP Cluster_391133 V1203886 U, W Pfam:YadA COG5295 Cluster_758408 V1203888 P tonB-dependent Receptor COG4771 Cluster_458838 V1203889 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_800729 V1203892 S NA 121PH Cluster_737900 V1203894 E amino acid COG0531 Cluster_407051 V1203902 G Alpha-1,2-mannosidase COG3537 Cluster_408806 V1203903 S NA 11QNK Cluster_412485 V1203905 map00052,map00511,map01100 G Glycoside hydrolase family 2 TIM barrel COG3250 Cluster_669689 V1203908 ABIGI S Abortive infection protein AbiGI 11WH3 Cluster_628988 V1203909 YLXM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) COG2739 Cluster_419700 V1203912 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_425144 V1203913 MANY map00051,map00520,map01100,map02060 G PTS System COG3715 Cluster_621482 V1203918 S Domain of unknown function (DUF955) 0ZI1U Cluster_477911 V1203920 DINB L Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) COG0389 Cluster_683069 V1203925 REP L Replication Protein COG5527 Cluster_497085 V1203927 NRDI F Probably involved in ribonucleotide reductase function (By similarity) COG1780 Cluster_754855 V1203928 J endoribonuclease L-psp COG0251 Cluster_434874 V1203932 S relaxase mobilization nuclease domain protein 0XNXG Cluster_436915 V1203933 S Membrane COG0730 Cluster_446966 V1203944 L Integrase 0YTFQ Cluster_446967 V1203945 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_504676 V1203949 S 5'-phosphate oxidase COG3576 Cluster_454937 V1203950 S conjugative transposon protein 0XVMR Cluster_454938 V1203951 L helicase COG4646 Cluster_458840 V1203953 S pathogenesis 0XR1H Cluster_458841 V1203954 SERB map00260,map00680,map01100,map01120,map01230 E phosphoserine phosphatase COG0560 Cluster_904728 V1203959 RNHB map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0164 Cluster_460888 V1203960 S Membrane 11YSX Cluster_460889 V1203961 L Dna topoisomerase COG0550 Cluster_463010 V1203964 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_863702 V1203965 S Phage terminase small subunit 11F23 Cluster_465094 V1203967 S membrane 0Z8C3 Cluster_467177 V1203969 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_573148 V1203970 CDPW8_0150 K Antirepressor COG3645 Cluster_718134 V1203971 S peptidase family M49 0XRK4 Cluster_592565 V1203972 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_471462 V1203974 V abc transporter COG1132 Cluster_592567 V1203978 GLTS E Sodium Glutamate Symporter COG0786 Cluster_475711 V1203979 S NA 0YNH7 Cluster_714870 V1203980 SP_0119 L Nudix family COG0494 Cluster_475712 V1203981 S NA 0YZ82 Cluster_475713 V1203982 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_477912 V1203984 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_534374 V1203986 MSRA O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) COG0225 Cluster_585894 V1203987 BDP_1102 V abc transporter COG1136 Cluster_480331 V1203988 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_517805 V1203991 U TraG family COG3505 Cluster_484964 V1203993 U, W Inherit from COG: domain protein COG5295 Cluster_487242 V1203995 V Restriction modification system DNA (Specificity COG0732 Cluster_487243 V1203996 S NA 0YMVP Cluster_492095 V1203999 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_494574 V1204000 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_494575 V1204003 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_497087 V1204005 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_741353 V1204006 S NA 0ZPY9 Cluster_832088 V1204008 S haloacid dehalogenase-like hydrolase COG0637 Cluster_769872 V1204009 S NA 125NP Cluster_499738 V1204011 N Bacterial flagellin C-terminal helical region COG1344 Cluster_502283 V1204013 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_714871 V1204016 CADA P heavy metal translocating p-type ATPase COG2217 Cluster_809009 V1204018 S NA 0ZHU9 Cluster_509841 V1204019 M outer membrane autotransporter barrel domain protein COG3468 Cluster_515119 V1204021 FRDB map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020 C succinate dehydrogenase COG0479 Cluster_683070 V1204022 S NA 11QPQ Cluster_766091 V1204027 TRAM S conjugative transposon 0YI63 Cluster_523107 V1204033 S NA 0ZTYV Cluster_523108 V1204034 S NA 11GMQ Cluster_847845 V1204035 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_528805 V1204036 S integral membrane protein 11UKN Cluster_526037 V1204040 RPOD K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_526038 V1204041 AHCY map00270,map01100 H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) COG0499 Cluster_741354 V1204042 GALU map00040,map00052,map00500,map00520,map01100,map01110 M UTP-glucose-1-phosphate uridylyltransferase COG1210 Cluster_617818 V1204043 PPX map00230 F, P ppx gppa phosphatase COG1507 Cluster_531593 V1204050 CAS2 L CRISPR-associated protein cas2 11VHR Cluster_531594 V1204053 THRC map00260,map00750,map01100,map01120,map01230 E Threonine synthase COG0498 Cluster_534375 V1204055 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_534376 V1204056 TYRA map00400,map01100,map01110,map01230 E Chorismate mutase COG1605 Cluster_540083 V1204062 BISC map00450,map00780,map01100 C sulfoxide reductase COG0243 Cluster_836007 V1204066 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_592568 V1204067 S Domain of unknown function (DUF3387) 0Z3FV Cluster_545902 V1204068 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_785112 V1204073 DPS P During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction COG0783 Cluster_548961 V1204074 RNC map03008,map05205 K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) COG0571 Cluster_734605 V1204077 COMM O Mg chelatase subunit ChlI COG0606 Cluster_724805 V1204080 RDRB K Transcriptional regulator COG1349 Cluster_751426 V1204085 RARA L recombination factor protein RarA COG2256 Cluster_557637 V1204088 SCLAV_4715 S type i phosphodiesterase nucleotide pyrophosphatase COG1524 Cluster_665373 V1204090 L DNA alkylation repair enzyme COG4912 Cluster_560711 V1204091 AMYA2 map00500 G alpha amylase, catalytic 0XQRS Cluster_596038 V1204093 V Peptidase C39 family COG2274 Cluster_702206 V1204096 YMDB S appr-1-p processing domain protein COG2110 Cluster_859315 V1204102 S NA 0ZHU9 Cluster_569934 V1204104 DPPA map02010 E ABC transporter substrate-binding protein COG4166 Cluster_896125 V1204105 CICA E HAD-superfamily subfamily IB hydrolase COG0560 Cluster_569935 V1204108 S NA 12ATZ Cluster_569936 V1204110 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_573149 V1204112 S Protein of unknown function DUF86 COG2361 Cluster_573150 V1204113 PYRK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) COG0543 Cluster_576371 V1204114 ALGI M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_579457 V1204117 PSTC map02010 P phosphate abc transporter COG0573 Cluster_579458 V1204118 S regulatory protein COG3641 Cluster_582700 V1204120 COMM O Mg chelatase subunit ChlI COG0606 Cluster_585895 V1204125 S radical SAM domain protein 125RF Cluster_585897 V1204127 V Type I site-specific COG4096 Cluster_652850 V1204129 S NA 0YVCN Cluster_836008 V1204131 THID H phosphomethylpyrimidine kinase COG0351 Cluster_656972 V1204134 L DNA binding protein, excisionase family 0YKT7 Cluster_711478 V1204136 S relaxase mobilization nuclease domain protein 0XNXG Cluster_599560 V1204138 U, W Pfam:YadA COG5295 Cluster_596039 V1204139 FBPA K Fibronectin-binding protein COG1293 Cluster_599561 V1204140 WHIA K May be required for sporulation (By similarity) COG1481 Cluster_610411 V1204147 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_610412 V1204148 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_644728 V1204151 P Chloride channel COG0038 Cluster_617819 V1204152 YHAO L DNA repair exonuclease COG0420 Cluster_656973 V1204155 S NA 11U85 Cluster_621484 V1204156 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_632787 V1204161 K regulatoR COG3835 Cluster_640855 V1204164 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_640858 V1204170 ASPC map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aspartate aminotransferase COG0436 Cluster_809011 V1204173 S NA 0ZHU9 Cluster_644729 V1204174 S NA 0ZHU9 Cluster_692036 V1204175 S NA 0XW6Q Cluster_847847 V1204181 GPMA map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0588 Cluster_661213 V1204184 O Erythromycin esterase COG2312 Cluster_836010 V1204193 MUTT L hydrolase COG0494 Cluster_674065 V1204194 PURE map00230,map01100,map01110 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) COG0041 Cluster_683071 V1204211 RBSR K Transcriptional regulator COG1609 Cluster_687463 V1204217 MUTS2 L DNA mismatch repair protein COG0249 Cluster_702207 V1204219 S NA 0XR5V Cluster_233686 V1204220 S alpha beta COG1073 Cluster_140506 V1204221 TRAG map03070 U TraG TraD family protein COG3505 Cluster_826 V1204223 S NA 101UU Cluster_79155 V1204225 YPGD map02010 V ABC transporter COG1132 Cluster_302210 V1204226 YBJB S integral membrane protein COG4858 Cluster_165330 V1204227 HSDS V DNA specificity domain protein COG0732 Cluster_219617 V1204228 L recombinase (Phage integrase family) COG0582 Cluster_78783 V1204229 HSDM V Type I restriction-modification system, M subunit COG0286 Cluster_18411 V1204231 INLJ map05150 M Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps 1215X Cluster_537279 V1204242 K Peptidase S24-like protein COG2932 Cluster_450959 V1204246 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_30835 V1204252 U traE protein COG3451 Cluster_89055 V1204259 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) COG0438 Cluster_135873 V1204260 UMUC L ImpB MucB SamB family protein COG0389 Cluster_579459 V1204261 S NA 0XZJN Cluster_85115 V1204266 S NA 11H3W Cluster_250303 V1204267 SRTA M (sortase) family COG3764 Cluster_221966 V1204278 YPUA S secreted protein COG4086 Cluster_236083 V1204279 REP L Replication Protein COG5527 Cluster_313732 V1204280 S integral membrane protein 11QKN Cluster_5604 V1204287 S Pfam:TraG 11F36 Cluster_9228 V1204294 S Lpxtg-motif cell wall anchor domain protein 0XQBH Cluster_332041 V1204295 M Cell wall-associated hydrolase COG1388 Cluster_25114 V1204298 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_146509 V1204299 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_209391 V1204306 PSTC map02010 P phosphate abc transporter COG0573 Cluster_77812 V1204307 S Type IV secretion-system coupling protein DNA-binding domain 0YAV5 Cluster_106410 V1204313 WANG_0286 L Transposase COG2963 Cluster_22438 V1204316 PBP1A map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_355383 V1204317 MPTP_1202 S Lysm domain protein 11U6T Cluster_189013 V1204318 XERS L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) COG0582 Cluster_60389 V1204322 L Domain protein COG0507 Cluster_178619 V1204323 DAM map03430 L DNA adenine methylase COG0338 Cluster_515122 V1204334 MSRB O reductase COG0229 Cluster_566852 V1204335 S 5'-phosphate oxidase COG3576 Cluster_410664 V1204344 BSEL_0787 S Phage terminase small subunit COG3747 Cluster_50358 V1204345 ELI_1296 L Terminase, large subunit COG4626 Cluster_171964 V1204347 S Phage Portal Protein COG4695 Cluster_344101 V1204348 map04112 O ATP-dependent Clp protease, proteolytic subunit COG0740 Cluster_135060 V1204349 S phage major capsid protein, HK97 family 0XTEI Cluster_330476 V1204352 S Major tail protein 0Y77V Cluster_209392 V1204356 ENDA S DNA-entry nuclease 12175 Cluster_394749 V1204358 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_711480 V1204363 HUP L DNA-binding protein COG0776 Cluster_387697 V1204365 K regulatoR 0XUX9 Cluster_294024 V1204367 YXEH S hydrolase COG0561 Cluster_233687 V1204368 LACC map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G tagatose-6-phosphate kinase COG1105 Cluster_318417 V1204369 LACR2 K transcriptional regulator DeoR family COG1349 Cluster_507248 V1204370 PTS36A map00052,map01100,map02060 G PTS System COG1762 Cluster_110736 V1204372 PTS36C map00052,map01100,map02060 G PTS system, galactitol-specific IIc component COG3775 Cluster_313734 V1204374 map00051 G class II Aldolase COG0235 Cluster_266978 V1204379 METQ map02010 P Lipoprotein COG1464 Cluster_7801 V1204380 M Inherit from NOG: Cell Wall 1248X Cluster_375272 V1204384 LEPB map03060 U Signal peptidase i COG0681 Cluster_24570 V1204385 TOPB L Dna topoisomerase COG0550 Cluster_284473 V1204386 S Pfam:Phage_integr_N 0YI69 Cluster_148077 V1204392 S NA 0ZIMM Cluster_509843 V1204399 LACZ map00052,map00511,map00600,map01100 G beta-galactosidase COG3250 Cluster_517806 V1204400 L terminase (Small subunit) COG3747 Cluster_133477 V1204401 L Integrase COG0582 Cluster_227754 V1204404 S NA 0XU6J Cluster_392945 V1204405 K HTH_XRE COG1974 Cluster_769873 V1204406 CRO K HTH_XRE 0XYF7 Cluster_394751 V1204412 map00230 S relA SpoT domain protein COG2357 Cluster_370324 V1204413 PHOP map02020 T Transcriptional regulatory protein, C terminal 11FPD Cluster_139778 V1204414 S Membrane COG1808 Cluster_239875 V1204416 map02010 S ABC transporter COG4152 Cluster_318418 V1204417 S ABC-2 type transporter 11FXW Cluster_378816 V1204421 LDB1079 L integrase family COG0582 Cluster_315321 V1204431 YDHQ K Transcriptional regulator COG2188 Cluster_6396 V1204432 S Transglycosylase SLT domain COG5283 Cluster_167675 V1204434 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_678525 V1204435 K Transcriptional regulator 11VW1 Cluster_734606 V1204437 S NA 120D2 Cluster_741358 V1204439 HTH_0473 L Transposase COG0675 Cluster_603119 V1204442 SP_1143 S Toxin-antitoxin system, toxin component, RelE family COG4679 Cluster_721440 V1204443 K HTH_XRE 0XUC3 Cluster_260338 V1204446 LYS M Glyco_25 COG3757 Cluster_112760 V1204448 DSY2934 L Transposase 1012J Cluster_377041 V1204451 S NA 0YUG9 Cluster_692037 V1204454 ORFL L transposase COG2826 Cluster_656976 V1204455 S NA 0XVT8 Cluster_310714 V1204456 PNUC2 H nicotinamide mononucleotide transporter COG3201 Cluster_448990 V1204461 S Archaeal ATPase 0ZW9J Cluster_614032 V1204464 CHPA T transcriptional modulator of maze toxin, mazf COG2337 Cluster_517807 V1204465 HTH_0473 L Transposase COG0675 Cluster_582704 V1204467 L Inherit from COG: transposase COG2826 Cluster_231254 V1204472 S NA 123XQ Cluster_7873 V1204473 S phage tape measure protein COG5283 Cluster_292644 V1204476 S NA 0XNUC Cluster_469328 V1204478 DPNA L helicase COG4646 Cluster_144963 V1204479 L DnaB-like helicase C-terminal domain protein COG0305 Cluster_469329 V1204481 LDB1085 S NA 0YWIA Cluster_32308 V1204487 M NA 0YESU Cluster_456876 V1204488 FRVA map00051,map01100,map02060 G PTS System COG1762 Cluster_34779 V1204490 MTLR K TRANSCRIPTIONal COG3711 Cluster_191659 V1204495 map02020 T Histidine kinase COG2972 Cluster_231255 V1204497 S Protein of unknown function (DUF805) 0ZYU9 Cluster_31503 V1204502 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_127485 V1204503 YPDC S Conserved Protein COG3538 Cluster_302211 V1204507 map03440 K Transcriptional regulator 0XRI9 Cluster_721441 V1204510 map00051,map00052,map00520,map01100,map02060 G PTS System COG2893 Cluster_859318 V1204513 BH0311 L Transposase COG3328 Cluster_39950 V1204519 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_261665 V1204520 K Transcriptional regulator, ARAC family COG4753 Cluster_502284 V1204521 SP_1996 T Universal stress protein COG0589 Cluster_260339 V1204522 S Protein of unknown function (DUF3737) 0XTHF Cluster_347306 V1204527 CKL_1850 K phage regulatory protein, rha family COG3646 Cluster_582705 V1204529 S VRR-NUC domain protein 0Z445 Cluster_16269 V1204532 PACL P cation-transporting atpase COG0474 Cluster_585898 V1204533 S VRR-NUC domain protein 0Z445 Cluster_344102 V1204540 S NA 0XNUC Cluster_329079 V1204544 K AntA/AntB antirepressor COG3645 Cluster_820532 V1204546 CRO K HTH_XRE 0XYF7 Cluster_632788 V1204551 S NA 122AV Cluster_652852 V1204555 S UPF0145 protein COG0393 Cluster_289972 V1204556 S ABC superfamily ATP binding cassette transporter, permease 0YYAC Cluster_302212 V1204559 BL03485 K phage protein 121ZT Cluster_116992 V1204566 L helicase COG1061 Cluster_728052 V1204569 S phage protein 124IT Cluster_27779 V1204571 BL03493 L phage plasmid primase, p4 family COG4983 Cluster_414345 V1204573 BMUR_1332 S Domain of Unknown Function (DUF1599) 0XXR0 Cluster_497089 V1204574 S VRR-NUC domain protein 0Z445 Cluster_276386 V1204582 LYC M glycoside hydrolase, family 25 11T0J Cluster_599562 V1204585 SP_1143 S Toxin-antitoxin system, toxin component, RelE family COG4679 Cluster_132634 V1204586 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_284474 V1204587 D DivIVA protein COG3599 Cluster_15223 V1204588 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_403553 V1204589 NUDF map00230 F nudix hydrolase COG0494 Cluster_353714 V1204591 MTNN map00270,map01100 F Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) COG0775 Cluster_166876 V1204592 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_287321 V1204594 NADE map00760,map01100 H nh(3)-dependent nad( ) synthetase COG0171 Cluster_442949 V1204595 YFBM K acetyltransferase COG0454 Cluster_509844 V1204596 YEBR T gaf domain protein COG1956 Cluster_306547 V1204597 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_8648 V1204599 S Lpxtg-motif cell wall anchor domain protein 0XQBH Cluster_17141 V1204600 MGTA P magnesium-translocating p-type atpase COG0474 Cluster_450960 V1204601 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0847 Cluster_76094 V1204602 E amino acid COG0531 Cluster_262957 V1204603 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_419701 V1204604 XPT map00230,map01100,map01110 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) COG0503 Cluster_66856 V1204605 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_182982 V1204606 PEPP map00310,map00780,map01100 E peptidase M24 COG0006 Cluster_284475 V1204607 S integral membrane protein COG1284 Cluster_579463 V1204609 GG9_0529 S Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) 1248I Cluster_589198 V1204611 S NA 11GVV Cluster_832090 V1204612 map00362,map00621,map00622,map01100,map01120 S Tautomerase enzyme 0XVB0 Cluster_875777 V1204613 YJHA S Endonuclease Exonuclease phosphatase 0XNVA Cluster_640862 V1204614 YJHA S Endonuclease Exonuclease phosphatase 0XNVA Cluster_656977 V1204615 YJHA S Endonuclease Exonuclease phosphatase 0XNVA Cluster_57019 V1204616 S Membrane 0Y3RG Cluster_702208 V1204617 CINI S Hydrolase COG1073 Cluster_257711 V1204618 CAS2 L CRISPR-associated protein cas2 11VHR Cluster_236084 V1204619 CAS1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) COG1518 Cluster_375273 V1204620 CASE L crispr-associated protein 0XPHC Cluster_338104 V1204621 CAS5E L crispr-associated protein 11JEJ Cluster_180319 V1204622 CSE4 L Crispr-associated protein, cse4 family 0Y6PV Cluster_405360 V1204623 CASB S CRISPR system CASCADE complex protein CasB 0ZXJT Cluster_121385 V1204625 S Transglycosylase SLT domain COG5283 Cluster_551869 V1204627 S phage Tail Protein 129AY Cluster_398265 V1204628 V prophage pi1 protein 32 COG1403 Cluster_196145 V1204633 YABB map00340,map00350,map00624,map01120 L Methyltransferase COG4123 Cluster_392946 V1204634 PLSC map00561,map00564,map01100 I Acyl-transferase COG0204 Cluster_165331 V1204635 CFA M cyclopropane-fatty-acyl-phospholipid synthase COG2230 Cluster_166877 V1204636 S Outer surface protein COG3589 Cluster_154449 V1204638 S Abortive infection protein COG1106 Cluster_95698 V1204639 HSDM V type I restriction-modification system COG0286 Cluster_28352 V1204640 MALZ map00052,map00500,map01100 G Alpha-glucosidase COG1501 Cluster_260340 V1204643 K Transcriptional regulator 0Y1S3 Cluster_721442 V1204644 TXE S Addiction module toxin, Txe YoeB family COG4115 Cluster_632790 V1204646 S Inherit from COG: Protein of unknown function (DUF1093) COG5294 Cluster_358747 V1204649 COBQ S Glutamine amidotransferase COG3442 Cluster_551870 V1204650 S Addiction module antitoxin, RelB DinJ family 0XUTM Cluster_12289 V1204652 M Cell surface protein 11GRZ Cluster_592569 V1204655 STRIC_0432 L Transposase (IS4 family 11HCS Cluster_345736 V1204656 FRLR K (GntR family) (Transcriptional regulator COG2188 Cluster_225499 V1204657 G oxidoreductase COG0673 Cluster_344103 V1204658 DEOC map00030 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) COG0274 Cluster_554716 V1204659 K PemK-like protein 0ZMEC Cluster_67519 V1204660 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_421499 V1204662 S Sel1 repeat COG0790 Cluster_205037 V1204664 S NA 0Z1CQ Cluster_517808 V1204666 S HIRAN domain 0XVUM Cluster_176122 V1204667 map03420,map03430 S UvrD/REP helicase N-terminal domain 174DY@proNOG Cluster_70538 V1204668 S NA 0XR66 Cluster_108792 V1204669 AMET_0416 S Phage-associated protein, HI1409 family COG3567 Cluster_355384 V1204670 AMET_0417 S Phage head morphogenesis protein COG2369 Cluster_166878 V1204672 AMET_0418 S Uncharacterized protein conserved in bacteria (DUF2213) COG3566 Cluster_232420 V1204674 AMET_0420 S Uncharacterized protein conserved in bacteria (DUF2184) COG4834 Cluster_375274 V1204676 AMET_0423 S NA 120SA Cluster_129608 V1204679 AMET_0426 S Protein of unknown function (DUF3383) 11UPU Cluster_531596 V1204680 AMET_0427 S NA 0XUEQ Cluster_210467 V1204683 S LysM domain 0YPBZ Cluster_191660 V1204685 AMET_0433 S NA 11WKE Cluster_158688 V1204688 AMET_0436 S Bacteriophage protein COG3299 Cluster_156096 V1204690 PLNI S CAAX amino terminal protease family 0XW1D Cluster_300816 V1204692 COF S Hydrolase COG0561 Cluster_321379 V1204694 OPPA E ABC transporter COG0747 Cluster_515125 V1204696 S Gcn5-related n-acetyltransferase 1221G Cluster_39300 V1204704 FRUA map00051,map01100,map02060 G PTS System COG1445 Cluster_103997 V1204705 map02020 T Histidine kinase COG2972 Cluster_122826 V1204706 ALL2459 S ATP GTP Binding Protein 0XQ3U Cluster_30953 V1204707 L DEAD DEAH box helicase COG1201 Cluster_120616 V1204708 CELB map00052,map01100,map02060 G Pts system COG1455 Cluster_414346 V1204709 BL03733 map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_373555 V1204710 S Antibiotic biosynthesis monooxygenase 0Y2XH Cluster_358748 V1204711 GLPQ map00564 C glycerophosphoryl diester phosphodiesterase COG0584 Cluster_315322 V1204716 K anti-repressor COG3645 Cluster_148819 V1204717 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_737904 V1204718 YAGE E amino acid COG0531 Cluster_77813 V1204719 map02010 V ABC transporter COG1132 Cluster_7098 V1204720 S inulin fructotransferase 0XRZB Cluster_3607 V1204721 ELI_1307 M phage tail tape measure protein COG5283 Cluster_545904 V1204722 GALA map00052,map00561,map00600,map00603 G alpha-galactosidase COG3345 Cluster_181153 V1204723 MSMK map02010 G ABC transporter, ATP-binding protein COG3839 Cluster_57514 V1204724 C Fumarate reduCtase COG1053 Cluster_103419 V1204725 YFLS P transporter COG0471 Cluster_262958 V1204726 MLER K malolactic fermentation system COG0583 Cluster_54997 V1204727 C Fumarate reduCtase COG1053 Cluster_266979 V1204728 MLER K malolactic fermentation system COG0583 Cluster_678527 V1204729 S NA 11GVV Cluster_507250 V1204730 S NA 11GVV Cluster_246472 V1204731 COAA map00770,map01100 H pantothenic acid kinase COG1072 Cluster_465096 V1204732 BL02883 S Membrane 0XVF5 Cluster_327581 V1204733 SDAAB map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase, iron-sulfur-dependent, beta subunit COG1760 Cluster_18858 V1204734 ADHE map00010,map00051,map00071,map00350,map00362,map00363,map00591,map00620,map00621,map00622,map00625,map00626,map00650,map01100,map01110,map01120 C Dehydrogenase COG1454 Cluster_157809 V1204741 M n-acetylmuramoyl-l-alanine amidase 11R58 Cluster_436919 V1204742 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_5057 V1204753 M Cell surface protein 11GRZ Cluster_10082 V1204754 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_322940 V1204755 CADA P p-type atpase COG2217 Cluster_540085 V1204756 ACIN_0074 L Transposase COG3464 Cluster_734609 V1204757 S Membrane 0XQ7F Cluster_232421 V1204758 SCRR K Transcriptional regulator COG1609 Cluster_70887 V1204760 OPPA map02010 E Extracellular solute-binding protein, family 5 COG4166 Cluster_138233 V1204761 HFLX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COG2262 Cluster_205038 V1204762 S NA 11VH8 Cluster_46354 V1204768 MUTL map03430 L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) COG0323 Cluster_1546 V1204771 M Cell surface protein 11GRZ Cluster_313735 V1204772 SBND G Major Facilitator 0ZVCH Cluster_79477 V1204773 LMRB P Drug resistance transporter EmrB QacA 0XNN3 Cluster_78110 V1204774 map02010 V ABC transporter COG1132 Cluster_319893 V1204776 map00350,map00362,map00627,map00642,map00903,map01120 J -acetyltransferase COG1670 Cluster_335029 V1204777 C nitroreductase COG0778 Cluster_243871 V1204778 APPC map02010 P ABC superfamily ATP binding cassette transporter ABC protein COG1173 Cluster_209393 V1204779 OPPD E, P ABC transporter COG0444 Cluster_111427 V1204781 YGCS G Major Facilitator superfamily 0XQKC Cluster_72154 V1204783 OPPA map02010 E Extracellular solute-binding protein, family 5 COG4166 Cluster_228936 V1204785 G oxidoreductase COG0673 Cluster_21077 V1204788 UVRA map03420 L excinuclease COG0178 Cluster_45951 V1204789 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_56497 V1204790 MDLB map02010 V ABC transporter COG1132 Cluster_59071 V1204791 MDLA map02010 V ABC transporter transmembrane region COG1132 Cluster_780947 V1204792 YNEF S UPF0154 protein COG3763 Cluster_724806 V1204793 SP_1473 S UPF0291 protein COG4224 Cluster_162881 V1204794 DGOD map00052 M Galactonate dehydratase COG4948 Cluster_573151 V1204795 TPX O Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) COG2077 Cluster_785114 V1204796 L Transposase COG2826 Cluster_285915 V1204797 S ABC superfamily ATP binding cassette transporter, permease 0YYAC Cluster_155289 V1204798 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_92357 V1204799 S NA 120ST Cluster_188171 V1204800 XERS L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) COG0582 Cluster_548962 V1204802 YPHH map00362,map01100,map01120 S Cupin 2, conserved barrel domain protein COG1917 Cluster_423363 V1204803 YFDE C L-carnitine dehydratase bile acid-inducible protein F COG1804 Cluster_62625 V1204804 OXC map00630,map01100 E oxalyl-CoA decarboxylase COG0028 Cluster_305162 V1204805 PLNI S CAAX amino terminal protease family 0XW1D Cluster_171142 V1204806 E amino acid COG0531 Cluster_809013 V1204807 DSY2934 L Transposase 1012J Cluster_371941 V1204808 I PAP2 Family COG0671 Cluster_249039 V1204810 S Protein of unknown function (DUF805) 0ZYU9 Cluster_21404 V1204811 PBP1A map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_322941 V1204815 GLNQ map02010 E ABC transporter, ATP-binding protein COG1126 Cluster_576374 V1204816 RFBP M exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase (EC 2.7.8.6) COG2148 Cluster_731362 V1204817 CPSE M transferase COG2148 Cluster_387698 V1204818 YJDB S NA 128F1 Cluster_358750 V1204821 RDGB map00230,map00240,map01100 F Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) COG0127 Cluster_416133 V1204823 S NA 0YPVV Cluster_800734 V1204824 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_213813 V1204825 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_471464 V1204826 YJEE S protein family UPF0079, ATPase COG0802 Cluster_219618 V1204827 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_78784 V1204829 FADX map00620,map00640,map00643,map01100,map01120 I CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) COG4670 Cluster_295430 V1204830 K Transcriptional regulator COG0583 Cluster_695833 V1204833 MSMG map02010 P ABC transporter COG0395 Cluster_124089 V1204834 RUMAL_1137 L Transposase COG3436 Cluster_37489 V1204835 COMA map02010,map02020 V ATP-binding protein COG2274 Cluster_569941 V1204840 DXS map00730,map00900,map01100,map01110 H, I Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) COG1154 Cluster_283104 V1204841 DXS map00730,map00900,map01100,map01110 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) COG1154 Cluster_678528 V1204842 HXLR K Transcriptional regulator COG1733 Cluster_523112 V1204843 SP_0161 K, T lytTr DNA-binding domain protein COG3279 Cluster_344104 V1204844 ORFL L transposase COG2826 Cluster_126796 V1204849 PBUG S Xanthine uracil vitamin C permease COG2252 Cluster_83003 V1204850 S ABC transporter, ATP-binding protein COG0488 Cluster_434876 V1204852 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_614033 V1204857 K transcriptional Regulator LysR family 11Z5Z Cluster_97877 V1204858 LDB1095 map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020 C Fumarate reduCtase COG1053 Cluster_711486 V1204864 S Filamentation induced by cAMP protein fic COG3177 Cluster_124742 V1204870 YKGC map00010,map00020,map00260,map00280,map00480,map00620,map01100,map01110,map01120 C pyridine nucleotide-disulfide oxidoreductase COG1249 Cluster_77814 V1204871 YPGD map02010 V ABC transporter COG1132 Cluster_277692 V1204873 S NA 11GVV Cluster_762118 V1204877 S NA 0ZHU9 Cluster_256430 V1204887 MURQ map00520 G Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate COG2103 Cluster_110053 V1204888 ENC_19000 map00010 G glycoside hydrolase, family 1 COG2723 Cluster_731364 V1204900 G Drug resistance transporter EmrB QacA 0XNN3 Cluster_25599 V1204913 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_628989 V1204916 CHPA T transcriptional modulator of maze toxin, mazf COG2337 Cluster_98962 V1204924 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_145711 V1204934 LYS M Glyco_25 COG3757 Cluster_147278 V1204942 SP_1634 S Protein of unknown function (DUF2974) 0XSVF Cluster_589199 V1204962 ERIC P Chloride channel COG0038 Cluster_193475 V1204965 H UBA THIF-type NAD FAD binding protein COG0476 Cluster_728054 V1204970 S NA 0ZHU9 Cluster_178620 V1204971 LGAS_0572 L Integrase COG0582 Cluster_72155 V1204979 SP_1222 V restriction endonuclease 0ZVJ1 Cluster_573152 V1204988 S NA 0ZHU9 Cluster_855406 V1204994 S NA 0ZHU9 Cluster_450961 V1204997 S NA 0ZHU9 Cluster_606736 V1205000 S NA 0ZHU9 Cluster_579466 V1205001 S NA 0ZHU9 Cluster_606737 V1205022 SBND G Major Facilitator 0ZVCH Cluster_335030 V1205032 S NA 123QA Cluster_661218 V1205039 S NA 0ZHU9 Cluster_149584 V1205060 G Drug resistance transporter EmrB QacA 0XNN3 Cluster_780953 V1205061 S NA 0ZHU9 Cluster_589200 V1205082 S NA 0ZHU9 Cluster_105185 V1205088 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_463012 V1205115 S NA 0ZHU9 Cluster_773523 V1205133 S NA 0ZHU9 Cluster_656979 V1205139 S NA 0ZHU9 Cluster_614035 V1205154 COMA map02010,map02020 V Peptidase C39 family COG2274 Cluster_401773 V1205155 COMA map02010,map02020 V ATP-binding protein COG2274 Cluster_661219 V1205210 S NA 0ZHU9 Cluster_391135 V1205221 S NA 0ZHU9 Cluster_599564 V1205244 S NA 17D58@proNOG Cluster_820542 V1205255 S NA 0ZHU9 Cluster_731366 V1205258 S NA 0ZHU9 Cluster_370326 V1205268 S NA 0ZHU9 Cluster_632797 V1205284 S NA 0ZHU9 Cluster_702213 V1205310 S NA 0ZHU9 Cluster_534379 V1205313 S NA 0ZHU9 Cluster_714880 V1205314 S NA 0ZHU9 Cluster_477914 V1205322 S NA 0ZHU9 Cluster_839842 V1205355 S NA 0ZHU9 Cluster_699121 V1205358 S NA 0ZHU9 Cluster_430944 V1205362 S NA 0ZHU9 Cluster_737907 V1205412 S NA 0ZHU9 Cluster_851615 V1205430 BL00144 L Transposase COG2801 Cluster_754868 V1205464 S NA 0ZHU9 Cluster_419702 V1205479 S NA 0YK7B Cluster_812995 V1205499 S NA 0ZHU9 Cluster_382309 V1205527 S NA 0ZHU9 Cluster_537282 V1205531 S NA 0ZHU9 Cluster_569942 V1205534 S NA 0ZHU9 Cluster_515128 V1205544 COMA map02010,map02020 V ATP-binding protein COG2274 Cluster_534382 V1205583 S NA 0ZHU9 Cluster_430945 V1205649 S NA 0ZHU9 Cluster_683077 V1205665 S NA 0ZHU9 Cluster_748006 V1205668 S NA 0ZHU9 Cluster_804991 V1205684 S NA 0ZHU9 Cluster_762134 V1205749 S NA 0ZHU9 Cluster_780965 V1205769 S NA 0ZHU9 Cluster_800742 V1205774 S NA 0ZHU9 Cluster_563656 V1205792 S NA 0ZHU9 Cluster_296556 V1020402 map00270,map00330,map00410,map00480,map01100 S synthase 0ZXB1 Cluster_458403 V1020406 S Htaa 11VMG Cluster_250068 V1020407 S (LipO)protein 11K11 Cluster_585219 V1020408 YUT E UreA transporter COG4413 Cluster_668864 V1020411 L DNA Repair Protein COG2003 Cluster_799889 V1020412 S NA 0Z727 Cluster_106309 V1020413 GLMU map00520,map01100,map01110 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) COG1207 Cluster_235870 V1020415 OPPC P Binding-protein-dependent transport systems inner membrane component COG1173 Cluster_71462 V1020416 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_204849 V1020417 ECORIM L Modification methylase EcoRI 0XPU0 Cluster_133337 V1020418 PURA map00230,map00250,map01100 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis COG0104 Cluster_79091 V1020419 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_147942 V1020421 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_334725 V1020422 C domain protein 0ZQ9H Cluster_446570 V1020423 M Polysaccharide Biosynthesis Protein 0XP95 Cluster_475246 V1020427 FTN map00860 P ferritin COG1528 Cluster_479818 V1020429 T Histidine kinase COG4585 Cluster_343816 V1020430 T HTH_LUXR COG2197 Cluster_548276 V1020431 ALDA map00010,map00040,map00053,map00071,map00280,map00281,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00626,map00640,map00903,map01100,map01110,map01120 C Aldehyde dehydrogenase family COG1012 Cluster_61755 V1020432 AAP map05150 M surface protein 0XSC2 Cluster_444549 V1020433 YKOE S ABC superfamily ATP binding cassette transporter membrane protein COG4721 Cluster_268127 V1020434 FBA map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01230 G Fructose-1,6-bisphosphate aldolase, class II COG0191 Cluster_380170 V1020435 map00230 S mutt nudix family protein 11RXE Cluster_677632 V1020436 YCHJ S UPF0225 protein COG3012 Cluster_142648 V1020437 map02010 M abc transporter permease protein COG4591 Cluster_85464 V1020441 NADE map00760,map01100 H Nad synthetase COG0388 Cluster_639972 V1020442 HXLR K Transcriptional regulator COG1733 Cluster_364934 V1020443 RGAI101_28 L transposase COG3316 Cluster_148696 V1020444 U, W Pfam:YadA COG5295 Cluster_129476 V1020448 M RHS repeat-associated core domain protein COG3209 Cluster_322669 V1020449 DAPB map00300,map01100,map01110,map01120,map01230 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) COG0289 Cluster_202716 V1020450 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_707770 V1020451 S NA 11EPN Cluster_682168 V1020452 RPSN map03010 J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) COG0199 Cluster_436498 V1020453 RPLE map03010 J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COG0094 Cluster_660315 V1020454 RPLX map03010 J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) COG0198 Cluster_494044 V1020455 S NA 0ZHU9 Cluster_209199 V1020456 RLUD J Pseudouridine synthase COG0564 Cluster_562958 V1020457 INV1 M NLP P60 protein COG0791 Cluster_213600 V1020458 MOXR S Atpase associated with various cellular activities aaa_3 COG0714 Cluster_720766 V1020459 RV1480 S von Willebrand factor COG1721 Cluster_560061 V1020460 TRMFO J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) COG1206 Cluster_238352 V1020464 CZCD P cation diffusion facilitator family transporter COG1230 Cluster_496541 V1020465 S Terminase, large subunit COG1783 Cluster_260124 V1020469 E, G Membrane COG0697 Cluster_620747 V1020470 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_724152 V1020471 RPSR map03010 J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) COG0238 Cluster_63418 V1020479 L Inherit from COG: Helicase COG1112 Cluster_327290 V1020481 S transporter gate domain protein 0XRV8 Cluster_127367 V1020484 map00521,map00562,map01100,map01110 I inositoL-3-phosphate synthase COG1260 Cluster_112631 V1020485 RAGB S RagB SusD domain protein 0XZ44 Cluster_63696 V1020486 P tonB-dependent Receptor 0XP5Y Cluster_701606 V1020487 S NA 0Y1Q6 Cluster_73073 V1020489 G transporter major facilitator family protein 0XRD8 Cluster_426663 V1020490 THIJ S intracellular protease Pfpi family COG0693 Cluster_153497 V1020491 HFLC O SPFH domain, Band 7 family protein COG0330 Cluster_548277 V1020492 NFED O, U Membrane protein implicated in regulation of membrane protease activity COG1585 Cluster_406703 V1020493 RIBE map00740,map01100 H riboflavin synthase, subunit alpha COG0307 Cluster_374955 V1020494 PGLC M Bacterial sugar transferase COG2148 Cluster_446571 V1020495 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_281464 V1020496 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_413986 V1020497 S Acetyltransferase (GNAT) family 0ZX86 Cluster_525410 V1020498 RPLK map03010 J This protein binds directly to 23S ribosomal RNA (By similarity) COG0080 Cluster_348645 V1020499 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_413987 V1020500 S NA 11FTP Cluster_227536 V1020508 map00030 G PfkB domain protein COG0524 Cluster_69543 V1020509 P tonB-dependent Receptor COG4771 Cluster_525411 V1020510 FOLK map00790,map01100 H 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase COG0801 Cluster_297929 V1020511 FECE map02010 P abc transporter COG1120 Cluster_73453 V1020522 L Pfam:Transposase_7 COG4644 Cluster_151882 V1020523 ICD map00020,map00480,map00720,map01100,map01110,map01120,map01210,map01230,map04146 C isocitrate dehydrogenase (NADP) COG0538 Cluster_496542 V1020525 S NA 0YGJM Cluster_609619 V1020527 ESTA S esterase COG0627 Cluster_396210 V1020528 RPLC map03010 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 Cluster_138870 V1020529 DINB L Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) COG0389 Cluster_296557 V1020530 VICX map03013 S domain protein COG1235 Cluster_406704 V1020533 MAF D Maf-like protein COG0424 Cluster_788388 V1020534 K XRE family transcriptional regulator 0XUC3 Cluster_97260 V1020537 COBN map00860,map01100 H cobaltochelatase, cobn subunit COG1429 Cluster_265424 V1020538 HEMG map00860,map01100,map01110 H protoporphyrinogen oxidase COG1232 Cluster_351757 V1020539 YWFI S chlorite dismutase COG3253 Cluster_251304 V1020540 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_240922 V1020541 I Lipid kinase, YegS Rv2252 BmrU family COG1597 Cluster_343817 V1020542 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_278834 V1020543 S Pfam:DUF1812 0YDYP Cluster_470992 V1020544 S NA 0YUF4 Cluster_65059 V1020545 IROC map02010 V abc transporter COG1132 Cluster_450563 V1020546 POLA_2 L DNA polymerase 0XRUF Cluster_444551 V1020547 S Phage-associated protein 11FS5 Cluster_819688 V1020549 S phage protein 0XQDU Cluster_194234 V1020550 S NA 126RX Cluster_394340 V1020553 RPOS map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_602313 V1020554 SCLAV_1038 S integral membrane protein COG3162 Cluster_296558 V1020562 PUNA map00230,map00240,map00760,map01100,map01110 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) COG0005 Cluster_152733 V1020563 ROCD map00300,map00330,map01100,map01110,map01120,map01210,map01230 E Catalyzes the interconversion of ornithine to glutamate semialdehyde (By similarity) COG4992 Cluster_591850 V1020564 S NA 0ZJP4 Cluster_65630 V1020565 PKNG map05152 T Serine Threonine protein kinase COG0515 Cluster_147943 V1020567 M Putative cell wall binding repeat 2 COG2247 Cluster_250069 V1020568 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG0582 Cluster_578757 V1020569 SCLAV_4555 M peptidase COG0739 Cluster_159369 V1020570 FADE25 map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I acyl-Coa dehydrogenase COG1960 Cluster_517241 V1020571 CTAF C Part of cytochrome c oxidase, its function is 11R1D Cluster_816048 V1020572 RPSU map03010 J 30S ribosomal protein S21 122SW Cluster_268128 V1020573 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_371631 V1020574 CYDC map02010 P ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC COG1132 Cluster_337795 V1020575 DUSB J Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_673127 V1020576 SECE map03060,map03070 U Preprotein translocase SecE subunit COG0690 Cluster_664518 V1020577 BL00143 L Transposase 122W1 Cluster_378472 V1020578 DCK map00230,map00240,map01100 F deoxynucleoside kinase COG1428 Cluster_254996 V1020580 MUTY map03410 L a g-specific adenine glycosylase COG1194 Cluster_530982 V1020581 MRAZ S Cell division protein mraZ COG2001 Cluster_176825 V1020588 P Phosphate-Selective Porin O and P 0ZV9B Cluster_152734 V1020590 S Inherit from NOG: (LipO)protein 103B0 Cluster_466705 V1020592 S Ser Thr phosphatase family protein COG1408 Cluster_292368 V1020593 HYPB K, O Hydrogenase accessory protein HypB COG0378 Cluster_479819 V1020594 O AhpC TSA family COG0526 Cluster_406705 V1020595 PNCA map00760,map01100 Q nicotinamidase COG1335 Cluster_153498 V1020596 EAPA map00565,map01100,map04146 C FAD linked oxidase domain protein COG0277 Cluster_551257 V1020599 S Domain of unknown function (DUF3127) 126YQ Cluster_188870 V1020600 K Transcriptional regulator 0XPSK Cluster_551874 V1205802 S NA 0ZHU9 Cluster_785126 V1205804 S NA 0ZHU9 Cluster_800744 V1205829 S NA 0ZHU9 Cluster_718142 V1205879 S NA 0ZHU9 Cluster_904744 V1205919 S NA 0ZHU9 Cluster_687471 V1205924 S NA 0ZHU9 Cluster_699123 V1205935 S NA 0ZHU9 Cluster_592573 V1205940 S NA 0ZHU9 Cluster_640872 V1205973 S NA 0ZHU9 Cluster_494578 V1205975 S NA 0ZHU9 Cluster_796872 V1205994 S NA 0ZHU9 Cluster_614043 V1206034 S NA 0ZHU9 Cluster_754873 V1206079 S NA 0ZHU9 Cluster_718145 V1206091 S NA 0ZHU9 Cluster_526043 V1206114 M NA 0YESU Cluster_528808 V1206128 GLVC map00010,map02060 G PTS System COG1264 Cluster_921279 V1206164 S NA 0ZHU9 Cluster_734617 V1206215 S NA 0ZHU9 Cluster_648796 V1206224 S NA 0ZHU9 Cluster_683080 V1206245 S NA 0ZHU9 Cluster_925272 V1206256 S NA 0ZHU9 Cluster_777269 V1206274 S NA 0ZHU9 Cluster_766113 V1206323 S NA 0ZHU9 Cluster_789124 V1206325 S NA 0ZHU9 Cluster_769888 V1206350 S NA 185WP@proNOG Cluster_836027 V1206369 S NA 0ZHU9 Cluster_632802 V1206407 YAGE E amino acid COG0531 Cluster_636839 V1206418 S NA 0ZHU9 Cluster_669704 V1206470 S NA 0ZHU9 Cluster_792904 V1206496 S NA 0ZHU9 Cluster_147279 V1206511 ECSB U (ABC) transporter COG4473 Cluster_336565 V1206513 S NA 0XV6C Cluster_200881 V1206514 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_828422 V1206515 S Filamentation induced by cAMP protein fic COG3177 Cluster_687478 V1206517 CORA P transporter COG0598 Cluster_438965 V1206519 PYRR map00240,map01100 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) COG2065 Cluster_57020 V1206528 GLPQ map00564 C glycerophosphoryl diester phosphodiesterase COG4781 Cluster_103420 V1206538 M NA 0YESU Cluster_585910 V1206553 S NA 0ZHU9 Cluster_762143 V1206562 S NA 0ZHU9 Cluster_603128 V1206572 S NA 0ZHU9 Cluster_785132 V1206579 K transcriptional regulator MERR family 1248T Cluster_847867 V1206580 S Membrane 11TU2 Cluster_644739 V1206586 S NA 0ZHU9 Cluster_632806 V1206628 S NA 0ZHU9 Cluster_327582 V1206635 S NA 11GVV Cluster_863736 V1206658 S NA 0ZHU9 Cluster_816804 V1206693 S NA 0ZHU9 Cluster_385851 V1206701 GND map00030,map00480,map01100,map01110,map01120 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) COG0362 Cluster_632807 V1206706 S NA 0ZHU9 Cluster_512427 V1206707 S NA 0ZHU9 Cluster_606743 V1206711 S NA 0ZHU9 Cluster_614046 V1206766 S NA 0ZHU9 Cluster_867776 V1206843 S NA 0ZHU9 Cluster_489600 V1206845 LCTP C L-lactate COG1620 Cluster_494579 V1206849 L Topoisomerase COG0550 Cluster_887921 V1206904 S NA 0ZHU9 Cluster_579472 V1206988 S NA 0ZHU9 Cluster_596050 V1207012 M Cell wall binding repeat 2-containing protein COG2247 Cluster_721463 V1207042 S NA 0ZHU9 Cluster_780980 V1207047 S NA 0ZHU9 Cluster_632808 V1207069 TRXA O Thioredoxin COG0526 Cluster_777277 V1207144 AMET_0417 S Phage head morphogenesis protein COG2369 Cluster_102248 V1207148 HSDS V restriction modification system DNA specificity domain COG0732 Cluster_160370 V1207149 THETH_0161 L Transposase COG3328 Cluster_557649 V1207150 RPSH map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) COG0096 Cluster_173708 V1207151 DINB L Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) COG0389 Cluster_832124 V1207156 RIBU S Membrane COG3601 Cluster_313736 V1207157 BH0311 L Transposase COG3328 Cluster_674079 V1207158 S NA 0ZHU9 Cluster_528809 V1207163 S NA 0ZHU9 Cluster_82538 V1207166 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_585911 V1207167 S Protein of unknown function (DUF1304) 0XV9E Cluster_582718 V1207168 S NA 0ZHU9 Cluster_614048 V1207171 S NA 0ZHU9 Cluster_268383 V1207174 S NA 11GVV Cluster_309277 V1207177 MNOD_0308 L Transposase COG3666 Cluster_828429 V1207179 DKGA1 C reductase COG0656 Cluster_428971 V1207185 WECD map00350,map00362,map00627,map00642,map00903,map01120 S -acetyltransferase 11PF0 Cluster_253990 V1207193 SDAA map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase COG1760 Cluster_121386 V1207195 map02010 G ABC transporter COG1653 Cluster_494580 V1207196 S NA 0ZHU9 Cluster_665395 V1207216 S NA 0ZHU9 Cluster_313737 V1207235 STP T phosphatase COG0631 Cluster_113499 V1207252 CELB map02060 G iic component COG1455 Cluster_548964 V1207255 S NA 0ZHU9 Cluster_566857 V1207259 BMUR_1332 S Domain of Unknown Function (DUF1599) 0XXR0 Cluster_159540 V1207310 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_589204 V1207311 S NA 0ZHU9 Cluster_182077 V1207325 M Cell surface protein 11GRZ Cluster_509848 V1207366 S NA 0ZHU9 Cluster_648801 V1207385 S NA 0ZHU9 Cluster_879814 V1207394 S NA 0ZHU9 Cluster_560720 V1207409 S NA 0ZHU9 Cluster_272372 V1207411 PGM map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_273702 V1207412 S NA 11GVV Cluster_917429 V1207417 PACA map00120,map00121,map01100 M Choloylglycine hydrolase COG3049 Cluster_450963 V1207460 S NA 0ZHU9 Cluster_327583 V1207469 ECSA V abc transporter atp-binding protein COG1131 Cluster_446968 V1207470 S NA 0ZHU9 Cluster_805006 V1207534 S NA 0ZHU9 Cluster_632812 V1207574 S NA 0ZHU9 Cluster_345737 V1207580 S NA 0ZHU9 Cluster_816810 V1207611 S NA 0ZHU9 Cluster_836041 V1207624 S NA 0ZHU9 Cluster_702220 V1207669 S NA 0YXBD Cluster_442952 V1207688 S NA 0ZHU9 Cluster_674082 V1207689 S NA 0ZHU9 Cluster_412486 V1207741 S NA 0ZHU9 Cluster_792920 V1207745 S NA 0ZHU9 Cluster_711510 V1207754 S NA 0ZHU9 Cluster_430947 V1207778 map00363,map00960,map01120 I esterase COG0657 Cluster_350216 V1020603 VICR map02020 T response regulator COG0745 Cluster_424780 V1020604 G transporter major facilitator family protein 0XRD8 Cluster_572442 V1020605 S NA 11VA3 Cluster_348646 V1020606 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_426664 V1020607 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_291044 V1020612 map02010 P Cobalt transport protein COG0619 Cluster_68819 V1020614 MEND map00130,map01100,map01110 H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) COG1165 Cluster_673129 V1020615 T Histidine kinase COG4585 Cluster_337796 V1020616 SSCG_03030 map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_509296 V1020617 S Transporter Permease Protein 0ZURF Cluster_373252 V1020620 UPP map00240,map01100 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) COG0035 Cluster_356749 V1020621 S Inherit from COG: esterase COG2819 Cluster_155966 V1020622 RLUA J Pseudouridine synthase COG0564 Cluster_301957 V1020624 YYCO S Orthopoxvirus protein of unknown function (DUF830) COG3863 Cluster_185399 V1020626 GCVT map00260,map00670,map00910,map01100 E The glycine cleavage system catalyzes the degradation of glycine (By similarity) COG0404 Cluster_115428 V1020628 CYCA E amino acid COG1113 Cluster_479820 V1020629 USPR K MarR family Transcriptional regulator 12AHX Cluster_421147 V1020633 JAG S Single-stranded nucleic acid binding R3H domain-containing protein COG1847 Cluster_295159 V1020634 SP_1245 S hydrolase COG0561 Cluster_562960 V1020635 YIDB S Bacterial protein of unknown function (DUF937) COG3753 Cluster_456480 V1020637 S phage protein 0XQDU Cluster_315018 V1020639 S Short-chain dehydrogenase reductase sdr COG0300 Cluster_519822 V1020640 S Membrane 12424 Cluster_530983 V1020642 S Protein of unknown function (DUF3021) 0YSIW Cluster_444552 V1020643 HSLV O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) COG5405 Cluster_358439 V1020645 CMK map00240,map00410,map00770,map01100,map01110 F Cytidine monophosphate kinase COG0283 Cluster_88040 V1020646 MQO3 map00620 C malate dehydrogenase (quinone) COG0579 Cluster_300548 V1020647 map02010 P cobalt transport COG0619 Cluster_129477 V1020651 S NA 11JA1 Cluster_569250 V1020654 S NA 124XV Cluster_624490 V1020655 PPNK map00760,map01100 G Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) COG0061 Cluster_148697 V1020656 L Integrase 0YTFQ Cluster_70486 V1020657 PRIA map03440 L Primosomal protein n' COG1198 Cluster_430571 V1020659 DEF J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) COG0242 Cluster_545236 V1020660 L Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) COG0816 Cluster_473118 V1020661 S sporulation and cell division repeat protein 11VBB Cluster_772715 V1020662 S NA 11XBE Cluster_415800 V1020663 map00350,map00362,map00627,map00642,map00903,map01120 S -acetyltransferase 11TPW Cluster_110594 V1020664 TNAA map00380 E tryptophanase EC 4.1.99.1 COG3033 Cluster_404970 V1020665 RIBE map00740,map01100 H riboflavin synthase, subunit alpha COG0307 Cluster_150298 V1020666 S NA 0YZKI Cluster_392599 V1020668 RECR map03440 L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) COG0353 Cluster_673130 V1020669 YBAB S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) COG0718 Cluster_161068 V1020670 HIPO map00360 E amidohydrolase COG1473 Cluster_588475 V1020671 PAND map00410,map00770,map01100,map01110 H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) COG0853 Cluster_264079 V1020672 PANC map00410,map00770,map01100,map01110 H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) COG0414 Cluster_175179 V1020673 S Archaeal ATPase COG1672 Cluster_144821 V1020674 PMT M glycosyl transferase, family 39 COG1928 Cluster_581976 V1020675 RSMI G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 Cluster_656167 V1020676 S NA 0Y25P Cluster_126664 V1020677 S NA 0XQBQ Cluster_76706 V1020684 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_358440 V1020687 CINA H competence damage-inducible protein COG1546 Cluster_361652 V1020688 PGSA map00564,map01100 I cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase COG0558 Cluster_533758 V1020690 DPS P Ferritin, Dps family protein COG0783 Cluster_436499 V1020691 MURQ map00520 G Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate COG2103 Cluster_196793 V1020692 YLEB S Outer surface protein COG3589 Cluster_346970 V1020695 S SNARE associated Golgi protein 0YNB0 Cluster_368315 V1020696 K Transcriptional regulator 12BGJ Cluster_178485 V1020697 M Sortase family COG3764 Cluster_152735 V1020700 TPAU_0274 L transposase COG3547 Cluster_682170 V1020701 S Addiction module antitoxin, RelB DinJ family 0XUTM Cluster_289766 V1020702 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_111301 V1020704 S NA 0YRUB Cluster_522524 V1020705 YBBP S TIGR00159 family COG1624 Cluster_201684 V1020706 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_237054 V1020707 S NA 0ZZWZ Cluster_221782 V1020708 YPDE map00500,map01100 E Peptidase m42 family protein COG1363 Cluster_330208 V1020709 E N-formylglutamate amidohydrolase 16XWF@proNOG Cluster_536669 V1020710 V Inherit from COG: Type II restriction enzyme, methylase COG1002 Cluster_134121 V1020711 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_149442 V1020714 SDAAA map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase COG1760 Cluster_227537 V1020715 S NA 0XTEF Cluster_157645 V1020716 YCHF J gtp-binding protein COG0012 Cluster_343818 V1020717 GLPF G Major Intrinsic Protein COG0580 Cluster_434459 V1020721 K RNA polymerase sigma-70 factor COG1595 Cluster_458404 V1020724 RIMM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) 11M4J Cluster_353441 V1020726 HMUY S NA 0XZUM Cluster_266739 V1020727 S NA 121T2 Cluster_509297 V1020730 S NA 11EPM Cluster_361653 V1020731 S NA 11EKM Cluster_486777 V1020733 FTN map00860 P ferritin COG1528 Cluster_210289 V1020735 LVIS_1721 L transposase COG2826 Cluster_417560 V1020736 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_464685 V1020737 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_479821 V1020738 MT3093 E amino acid-binding act 0ZHQE Cluster_740679 V1020739 GATC map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0721 Cluster_266740 V1020740 AGUB map00330,map01100 S hydrolase, carbon-nitrogen family COG0388 Cluster_295160 V1020741 FDHD C Necessary for formate dehydrogenase activity (By similarity) COG1526 Cluster_293745 V1020742 map00770,map01100 H Pantothenate kinase 109YT Cluster_178486 V1020743 SRTA M (sortase) family COG3764 Cluster_222942 V1020748 S Endonuclease Exonuclease phosphatase 0ZJ9Y Cluster_701607 V1020749 BCAV_3206 map05152 S Proteins of 100 residues with WXG COG4842 Cluster_695138 V1020750 S Protein of unknown function (DUF2580) COG4842 Cluster_94083 V1020752 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_381953 V1020757 GLGB map00500,map01100,map01110 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) COG0296 Cluster_514522 V1020758 S NA 0YIA5 Cluster_239635 V1020759 RSGA G May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) COG1162 Cluster_325726 V1020760 S NA 0XQBQ Cluster_293746 V1020761 CLOLE_0796 L recT protein COG3723 Cluster_413988 V1020762 map00363,map00960,map01120 I alpha beta hydrolase fold-3 domain protein COG0657 Cluster_272112 V1020763 YXKD S Uncharacterized protein conserved in bacteria (DUF2179) COG1284 Cluster_238353 V1020764 PANE map00770,map01100,map01110 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) COG1893 Cluster_75718 V1020768 S NA 0YDM2 Cluster_598852 V1020772 S HlyD-family transporter 0XPDT Cluster_146370 V1020773 map02010 V ABC transporter, ATP-binding protein COG1132 Cluster_144088 V1020776 P Receptor COG4771 Cluster_135734 V1020779 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_238354 V1020783 ARGF map00330,map01100,map01110,map01230 E ornithine carbamoyltransferase COG0078 Cluster_509298 V1020784 NRDI F Probably involved in ribonucleotide reductase function (By similarity) COG1780 Cluster_202717 V1020787 YKGB map00030,map01100,map01110,map01120 G 6-phosphogluconolactonase (EC 3.1.1.31) COG2706 Cluster_489066 V1020788 YWDH map00010,map00040,map00053,map00071,map00280,map00281,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00626,map00640,map00903,map01100,map01110,map01120 C Aldehyde dehydrogenase COG1012 Cluster_916683 V1020794 RPSJ map03010 J Involved in the binding of tRNA to the ribosomes (By similarity) COG0051 Cluster_397950 V1020795 RPLC map03010 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 Cluster_394341 V1020796 RPLD map03010 J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) COG0088 Cluster_924543 V1020798 PANE map00770,map01100,map01110 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) COG1893 Cluster_408457 V1020800 S NA 11EM0 Cluster_448994 V1207819 MDLA map02010 V ABC transporter transmembrane region COG1132 Cluster_847881 V1207825 S NA 0ZHU9 Cluster_724816 V1207827 S NA 0ZHU9 Cluster_705290 V1207833 S NA 0ZHU9 Cluster_711512 V1207846 S NA 0ZHU9 Cluster_678542 V1207888 S NA 0ZHU9 Cluster_796891 V1207909 S NA 0ZHU9 Cluster_507261 V1207972 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_507262 V1207973 S NA 0ZHU9 Cluster_614051 V1208010 S NA 0ZHU9 Cluster_734631 V1208041 S NA 0ZHU9 Cluster_796894 V1208047 S NA 0ZHU9 Cluster_548966 V1208075 map04112 M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) COG1589 Cluster_551877 V1208084 J TRAM domain COG2265 Cluster_554722 V1208090 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_557652 V1208107 CBPC M choline binding protein COG5263 Cluster_851653 V1208113 S NA 0ZHU9 Cluster_560725 V1208114 HPK31 T Histidine kinase COG0642 Cluster_762166 V1208115 S NA 0ZHU9 Cluster_669715 V1208122 S NA 0ZHU9 Cluster_678547 V1208159 S NA 185WP@proNOG Cluster_917439 V1208176 S NA 0ZHU9 Cluster_603135 V1208213 L Topoisomerase COG0550 Cluster_744662 V1208224 S NA 0ZHU9 Cluster_606748 V1208227 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_636847 V1208261 S NA 17D58@proNOG Cluster_871710 V1208272 S NA 0ZHU9 Cluster_859396 V1208336 S NA 0ZHU9 Cluster_344105 V1208359 S NA 11GVV Cluster_436921 V1208361 HIPMA_0065 L Transposase COG3328 Cluster_796896 V1208363 S NA 0ZHU9 Cluster_55241 V1208364 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_275052 V1208365 S NA 11GVV Cluster_75787 V1208368 map00020,map00190,map00623,map00650,map00720,map00984,map01100,map01110,map01120,map02020 C Flavocytochrome c COG1053 Cluster_560726 V1208369 GLNL map02020 T response regulator COG0784 Cluster_748022 V1208371 YAAA L UPF0246 protein COG3022 Cluster_512429 V1208376 OXLT G Major Facilitator 0XQUK Cluster_520351 V1208381 S NA 0ZHU9 Cluster_502293 V1208383 T Universal stress protein COG0589 Cluster_579476 V1208386 S NA 0ZHU9 Cluster_142765 V1208397 S NA COG4990 Cluster_360409 V1208413 K Sucrose operon repressor COG1609 Cluster_361979 V1208414 GLPT G transporter 0XPWC Cluster_477918 V1208425 TPX O Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) COG2077 Cluster_813022 V1208430 S Protein of unknown function (DUF3042) 0ZR85 Cluster_398267 V1208440 YHCG V abc transporter atp-binding protein COG1131 Cluster_632818 V1208442 S NA 0ZHU9 Cluster_157811 V1208451 Y0402 S enhancing factor (Viral) 0XNVM Cluster_160371 V1208456 GND map00030,map00480,map01100,map01110,map01120 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) COG0362 Cluster_573162 V1208474 S NA 0ZHU9 Cluster_596055 V1208481 S NA 0ZHU9 Cluster_847889 V1208493 S NA 0ZHU9 Cluster_315323 V1208495 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase ii COG0046 Cluster_467182 V1208496 RNHB map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0164 Cluster_432955 V1208497 YLQF K Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) COG1161 Cluster_454941 V1208501 S NA 0ZHU9 Cluster_266980 V1208504 LIPL H Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) COG0095 Cluster_448995 V1208511 YIFK E amino acid COG1113 Cluster_217326 V1208517 GTFA map00500 G Sucrose phosphorylase COG0366 Cluster_656997 V1208518 TRXA O Thioredoxin COG0526 Cluster_357073 V1208523 HELD map03420,map03430 L helicase COG3973 Cluster_425146 V1208526 LYTR K TRANSCRIPTIONal COG1316 Cluster_269731 V1208531 PIPD E Dipeptidase COG4690 Cluster_239876 V1208539 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_350548 V1208544 NPDA map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_781007 V1208552 S NA 0ZHU9 Cluster_368610 V1208559 TERC P membrane protein, TerC COG0861 Cluster_714904 V1208579 COF S Hydrolase COG0561 Cluster_728090 V1208585 S NA 0ZHU9 Cluster_921330 V1208588 GLYA map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01230 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) COG0112 Cluster_545910 V1208590 map02020 V ABC transporter, permease COG0577 Cluster_335031 V1208593 S protease 0XW1D Cluster_332042 V1208599 YFDH map00051,map00510,map01100 M Glycosyl Transferase COG0463 Cluster_291284 V1208601 ERIC P Chloride channel COG0038 Cluster_302214 V1208607 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0516 Cluster_484970 V1208631 G Major Facilitator COG2814 Cluster_316848 V1208635 SUA J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0009 Cluster_333530 V1208657 ADHA map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120 C alcohol dehydrogenase COG1064 Cluster_335032 V1208663 RFAB map00540,map01100 M Glycosyl transferase (Group 1 COG0438 Cluster_460893 V1208664 S NA 123K0 Cluster_777290 V1208665 S NA 129UJ Cluster_338105 V1208669 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_338106 V1208674 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_340993 V1208677 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_674089 V1208679 YDEP K Transcriptional regulator COG1733 Cluster_625289 V1208680 FOLB map00790,map01100 H dihydroneopterin aldolase COG1539 Cluster_669716 V1208682 S NA 0ZHU9 Cluster_344107 V1208685 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_480336 V1208688 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_718160 V1208693 SEPF S Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) COG1799 Cluster_380540 V1208698 HADH map00360,map00362,map00650,map01100,map01120 C Dehydrogenase COG1250 Cluster_366992 V1208701 PEPX E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) 0XPUZ Cluster_357074 V1208705 TETP T Tetracycline resistance protein COG0480 Cluster_360410 V1208707 PEPX E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) 0XPUZ Cluster_610422 V1208712 YAAK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) COG0718 Cluster_492098 V1208713 NQR map00051,map00363,map00591,map00625,map00650,map01100,map01120 S Nadph-dependent fmn reductase COG0431 Cluster_805017 V1208715 S NA 17D58@proNOG Cluster_365288 V1208716 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_520352 V1208723 ANSA map00250,map00460,map00910,map01100,map01110 E L-asparaginase COG0252 Cluster_773560 V1208725 K Sucrose operon repressor COG1609 Cluster_389403 V1208729 FABG3 map00140,map01100 S Short-chain dehydrogenase reductase sdr COG1028 Cluster_371942 V1208731 LMRB P Lincomycin resistance protein LmrB 0XNN3 Cluster_531600 V1208734 SDS map00900,map01110 H synthase COG0142 Cluster_378818 V1208739 PSTS map02010,map02020,map05152 P phosphate COG0226 Cluster_380541 V1208741 S Inherit from NOG: domain protein 0XP4A Cluster_839900 V1208743 S NA 0ZHU9 Cluster_507263 V1208745 S NA 0ZHU9 Cluster_454942 V1208749 S Uncharacterized protein conserved in bacteria (DUF2252) COG4320 Cluster_625290 V1208751 S NA 0ZHU9 Cluster_475716 V1208752 PIPD E Dipeptidase COG4690 Cluster_385853 V1208754 CYDD map02010 V ABC, transporter COG4988 Cluster_387699 V1208759 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_394753 V1208770 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_497091 V1208781 YJDF S NA 11P5R Cluster_401774 V1208783 PTSI map00051,map01100,map02060 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) COG1080 Cluster_403555 V1208784 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_403556 V1208785 PLSX map00561,map00564,map01100 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) COG0416 Cluster_405362 V1208786 S Rib/alpha-like repeat 0YK85 Cluster_460894 V1208790 YECS map02010 E amino acid ABC transporter COG0765 Cluster_718161 V1208799 S NA 0ZHU9 Cluster_526050 V1208803 YIBE S YibE F family protein COG5438 Cluster_460895 V1208807 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_430948 V1208813 DPRA L DNA protecting protein DprA COG0758 Cluster_458845 V1208825 NRDF map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_463015 V1208829 YJCE P Na H antiporter COG0025 Cluster_731395 V1208834 ACYP map00620,map00627,map01120 C Acylphosphatase COG1254 Cluster_419704 V1208837 LMRB G Major Facilitator Superfamily 0XNN3 Cluster_492099 V1208838 MACB map02010 V Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) COG1136 Cluster_421503 V1208840 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (alpha subunit) COG0587 Cluster_421504 V1208845 PHND map02010 P phosphonate ABC transporter, periplasmic phosphonate-binding protein COG3221 Cluster_421505 V1208846 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_728094 V1208848 HELD map03420,map03430 L helicase COG3973 Cluster_425147 V1208852 G Major Facilitator COG0477 Cluster_563668 V1208860 YNER S HesB YadR YfhF-family protein COG4841 Cluster_475717 V1208862 YKOD map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_596057 V1208863 S NA 0ZHU9 Cluster_748025 V1208865 S NA 0ZHU9 Cluster_606749 V1208868 RSFS S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) COG0799 Cluster_792930 V1208869 YKHA map00903,map01040 I thioesterase Superfamily protein COG1607 Cluster_432956 V1208877 GLSA map00250,map00330,map00471,map00910,map01100,map01120,map04724,map04727,map04964 E Glutaminase COG2066 Cluster_545912 V1208888 ISPA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_896180 V1208889 RRMJ J Hemolysin A COG1189 Cluster_748026 V1208890 PGSA map00564,map01100 I cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase COG0558 Cluster_434878 V1208891 KINE T sensor protein 0XNMH Cluster_748027 V1208897 E, G EamA-like transporter family COG0697 Cluster_748028 V1208898 HELD map03420,map03430 L helicase COG3973 Cluster_436923 V1208899 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_599575 V1208902 SP_0889 S Death-On-Curing Family COG3654 Cluster_569949 V1208907 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_442953 V1208909 DNAB L replication initiation and membrane attachment protein COG3611 Cluster_442954 V1208912 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_442955 V1208914 YHAN S domain protein COG4717 Cluster_444935 V1208918 E amino acid COG0531 Cluster_444936 V1208920 UVRA map03420 L excinuclease COG0178 Cluster_446969 V1208922 RARA L recombination factor protein RarA COG2256 Cluster_471465 V1208935 NAPA2 P Na H antiporter COG0569 Cluster_450965 V1208937 NAPA P Sodium hydrogen exchanger COG0475 Cluster_452917 V1208941 GLNK map02020 T Histidine kinase COG0642 Cluster_454943 V1208942 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG2812 Cluster_644749 V1208947 YEAL S UPF0756 membrane protein COG2707 Cluster_458846 V1208950 GALA map00052,map00561,map00600,map00603 G alpha-galactosidase COG3345 Cluster_458847 V1208953 ARGH map00250,map00330,map01100,map01110,map01230 E arginosuccinase COG0165 Cluster_523122 V1208954 HELD map03420,map03430 L helicase COG3973 Cluster_460898 V1208958 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_463016 V1208961 YXIO G major facilitator superfamily COG2270 Cluster_648806 V1208962 S NA 0ZHU9 Cluster_463017 V1208965 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_465100 V1208967 S Uncharacterised protein family (UPF0104) COG0392 Cluster_734637 V1208968 S NA 0XQ6D Cluster_465101 V1208969 YICL E, G Transporter COG0697 Cluster_465102 V1208970 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_465103 V1208971 ECSB U (ABC) transporter COG4473 Cluster_467183 V1208976 MURF map00300,map00550,map01100 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) COG0770 Cluster_467184 V1208977 P Cadmium resistance transporter 0YIQW Cluster_497092 V1208979 SOJ D Chromosome Partitioning Protein COG1192 Cluster_471466 V1208985 PIPD E Dipeptidase COG4690 Cluster_636849 V1208990 SCRR K Sucrose operon repressor COG1609 Cluster_509850 V1208995 GPSA map00564 C NADPH-dependent glycerol-3-phosphate dehydrogenase COG0240 Cluster_475718 V1209002 MUTS2 map03430 L muts2 protein COG1193 Cluster_475719 V1209003 COMFA L Competence protein COG4098 Cluster_475720 V1209004 GAT map00230,map00983,map01100 F Glutamine amido-transferase COG0518 Cluster_576384 V1209007 WANG_1499 S Transposase 11N3I Cluster_477920 V1209008 LACZ map00052,map00511,map00600,map01100 G beta-galactosidase COG3250 Cluster_557653 V1209013 DING L helicase COG1199 Cluster_632820 V1209022 ASP1 S accessory Sec system protein Asp1 11JCE Cluster_741377 V1209024 VEG S Veg protein COG4466 Cluster_482646 V1209032 YVOA K (GntR family) (Transcriptional regulator COG2188 Cluster_482647 V1209034 YKII S NA 11GTZ Cluster_484971 V1209035 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_625292 V1209043 LYTS map02020 T Histidine kinase COG3275 Cluster_489601 V1209050 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_629003 V1209053 P drug resistance transporter, EmrB QacA subfamily 0XQZX Cluster_520353 V1209054 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_781010 V1209055 RPOZ map00230,map00240,map01100,map03020 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) COG1758 Cluster_762175 V1209059 RMAH K Transcriptional regulator 0XUB6 Cluster_867800 V1209060 CRCB2 D Protein CrcB homolog COG0239 Cluster_644750 V1209061 S Protein CrcB homolog 0XUV1 Cluster_526051 V1209063 K TRANSCRIPTIONAl REGULATOR GntR family COG2186 Cluster_554727 V1209066 S NA 0ZCWV Cluster_847895 V1209067 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_497093 V1209070 PATB map00270,map00450,map00920,map01100,map01110,map01230 E Aminotransferase class I and II COG1168 Cluster_843981 V1209072 NYLA map00330,map00360,map00380,map00627,map00643,map01120 J amidase (EC COG0154 Cluster_734638 V1209073 LYC M glycoside hydrolase, family 25 11T0J Cluster_836061 V1209076 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_499747 V1209077 ECFA2 map02010 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates COG1122 Cluster_531602 V1209078 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_499748 V1209081 NTPJ P Potassium uptake protein COG0168 Cluster_502294 V1209084 YLBL T domain protein COG3480 Cluster_537284 V1209087 S NA 0Z167 Cluster_502295 V1209088 LDH map00010,map00270,map00620,map00640,map01100,map01110,map01120 C L-lactate dehydrogenase COG0039 Cluster_809059 V1209089 S NA 0ZHU9 Cluster_507264 V1209091 ADDB L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination COG3857 Cluster_507265 V1209094 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_507266 V1209095 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_507267 V1209098 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_507268 V1209099 T EAL domain 11X2Y Cluster_507269 V1209100 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_824615 V1209104 ARLR map02020 T response regulator COG0745 Cluster_509851 V1209105 NSS S galactofuranosyltransferase 11KQ1 Cluster_563669 V1209112 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_515133 V1209123 LSA S (ABC) transporter COG0488 Cluster_515134 V1209128 S NA 11GVV Cluster_711517 V1209132 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_517811 V1209135 MREC M Involved in formation and maintenance of cell shape (By similarity) COG1792 Cluster_523123 V1209144 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_523124 V1209146 SP_1529 M Polysaccharide Biosynthesis Protein COG2244 Cluster_520356 V1209149 PNCA map00760,map01100 Q isochorismatase COG1335 Cluster_589211 V1209156 MSRA O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) COG0225 Cluster_526052 V1209159 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_528811 V1209166 LMRB P Lincomycin resistance protein LmrB 0XNN3 Cluster_526054 V1209168 G Major Facilitator 0XPHU Cluster_528812 V1209169 DING map00230,map00240,map01100,map03030,map03430,map03440 L helicase COG1199 Cluster_531603 V1209178 RLMB map00340,map00350,map00624,map01120 J RNA methyltransferase TrmH family group 3 COG0566 Cluster_661232 V1209188 MURE map00300,map00550 M mur ligase COG0769 Cluster_531604 V1209190 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_531605 V1209191 LPLA map00785,map01100 H Lipoate-protein, ligase COG0095 Cluster_545914 V1209192 RNJB map03018 O Metallo-Beta-Lactamase COG0595 Cluster_531606 V1209193 ARAB map00040,map01100 G Carbohydrate kinase COG1070 Cluster_537285 V1209200 PRFC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) COG4108 Cluster_537286 V1209205 EST I Carboxylesterase (EC 3.1.1.1) COG1647 Cluster_537287 V1209208 S Frg domain protein 0ZXCB Cluster_661233 V1209211 S NA 0Z8F5 Cluster_540093 V1209212 map03440 K Divergent AAA domain protein COG2865 Cluster_540094 V1209214 AZLC E azlc family COG1296 Cluster_537288 V1209216 SUFC O feS assembly ATPase SufC COG0396 Cluster_754909 V1209220 L Transposase COG2826 Cluster_542963 V1209224 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_621499 V1209230 YBEY map00240,map00983,map01100 F Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) COG0319 Cluster_705294 V1209237 LTRA S low temperature requirement protein COG4292 Cluster_695862 V1209238 RARA L recombination factor protein RarA COG2256 Cluster_545915 V1209239 DCK map00230,map00240,map01100 F deoxynucleoside kinase COG1428 Cluster_542965 V1209240 I esterase COG0657 Cluster_714907 V1209242 YPMS S Uncharacterized protein conserved in bacteria (DUF2140) COG4698 Cluster_900443 V1209243 S UPF0346 protein COG4479 Cluster_661234 V1209245 AMSD map00051 M Glycosyltransferase COG0438 Cluster_545916 V1209252 G phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 COG2211 Cluster_548969 V1209253 MDLA map02010 V ABC transporter transmembrane region COG1132 Cluster_548970 V1209257 T Universal stress protein COG0589 Cluster_548971 V1209258 L helicase COG4889 Cluster_554729 V1209263 HADH map00360,map00362,map00650,map01100,map01120 C Dehydrogenase COG1250 Cluster_554731 V1209269 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_554732 V1209272 YIHY S ribonuclease BN COG1295 Cluster_554733 V1209273 COPA P p-type ATPase COG2217 Cluster_554734 V1209276 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_724829 V1209282 CADA P heavy metal translocating p-type ATPase COG2217 Cluster_721483 V1209288 ZURA map02010 P ABC transporter COG1121 Cluster_560727 V1209293 PARC L DNA topoisomerase IV, subunit A COG0188 Cluster_754910 V1209305 C trp repressor binding protein COG0716 Cluster_592582 V1209307 L adenine specific DNA methyltransferase COG4889 Cluster_579479 V1209309 RPLQ map03010 J 50S ribosomal protein l17 COG0203 Cluster_563671 V1209314 CYDC map02010 V (ABC) transporter COG4987 Cluster_728097 V1209324 L helicase domain protein COG4889 Cluster_566862 V1209328 MBL D Rod shape-determining protein mreb COG1077 Cluster_566863 V1209331 ICAA map00561,map01100 M Glycosyl transferase, family 2 COG1215 Cluster_569952 V1209339 COPA P p-type ATPase COG2217 Cluster_569953 V1209341 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_569954 V1209344 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_573165 V1209348 YFHO S Membrane COG4485 Cluster_573166 V1209351 S NA 120ST Cluster_573167 V1209352 PRKC T serine threonine protein kinase COG2815 Cluster_576387 V1209361 KDGR K Transcriptional regulator COG1609 Cluster_576389 V1209366 ARAT map04113 G transporter 0XNQK Cluster_714908 V1209371 S Nadph-dependent fmn reductase COG0431 Cluster_748032 V1209372 RNC map03008,map05205 K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) COG0571 Cluster_699139 V1209373 L DNA ligase COG0272 Cluster_816828 V1209375 GLNL map02020 T response regulator COG0784 Cluster_724830 V1209377 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_582722 V1209381 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_781013 V1209385 RIBU S Membrane COG3601 Cluster_582723 V1209386 FTSI map00550,map01100 M penicillin-binding protein COG0768 Cluster_632821 V1209387 I acidPPc COG0671 Cluster_805023 V1209392 FOLA map00670,map00790,map01100 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) COG0262 Cluster_585916 V1209393 GATA map00970,map01100 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) COG0154 Cluster_721484 V1209396 YBEC E amino acid COG0531 Cluster_585917 V1209401 STPC map02010 V ABC transporter COG1131 Cluster_606750 V1209406 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_596059 V1209410 SCLAV_3855 K MarR family Transcriptional regulator 121KI Cluster_665401 V1209411 J Inherit from COG: Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA (By similarity) COG3270 Cluster_589213 V1209416 map02010 V ABC transporter COG1131 Cluster_592585 V1209421 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) COG0706 Cluster_592587 V1209428 ADDA L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation COG1074 Cluster_855450 V1209432 THIM map00730,map01100 H 4-methyl-5-beta-hydroxyethylthiazole kinase COG2145 Cluster_596061 V1209437 ARAD map00040,map00053,map01100,map01120 G L-ribulose-5-phosphate 4-epimerase COG0235 Cluster_820607 V1209438 DNAG map03030 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 Cluster_599576 V1209439 THID map00730,map01100 H phosphomethylpyrimidine kinase COG0351 Cluster_596062 V1209440 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_714909 V1209442 RPSP map03010 J 30s ribosomal protein S16 COG0228 Cluster_599577 V1209443 S Inherit from NOG: domain protein 0XP4A Cluster_603136 V1209449 SUHB map00521,map00562,map01100,map01110,map04070 G inositol monophosphatase COG0483 Cluster_603137 V1209451 map00051 S biosynthesis protein 0XQI4 Cluster_603138 V1209453 MRAY map00550,map01100 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) COG0472 Cluster_606751 V1209457 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_603139 V1209460 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_741379 V1209462 map00051 S biosynthesis protein 0XQI4 Cluster_699140 V1209463 YKII S NA 11GTZ Cluster_606752 V1209465 YQEH S ribosome biogenesis GTPase YqeH COG1161 Cluster_610424 V1209466 DACA map00550,map01100 M carboxypeptidase COG1686 Cluster_640883 V1209469 RECG map03440 L ATP-dependent DNA helicase recG COG1200 Cluster_705296 V1209470 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_610426 V1209471 YFHO S Membrane COG4485 Cluster_610427 V1209474 KINE T sensor protein 0XNMH Cluster_614058 V1209477 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_617837 V1209493 G phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 COG2211 Cluster_617838 V1209494 RSGA G May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) COG1162 Cluster_617840 V1209496 ARCT map00300,map00480,map01100,map01120,map01230 E Dipeptidase COG0624 Cluster_824621 V1209497 S Small integral membrane protein (DUF2273) COG5547 Cluster_617841 V1209500 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_621501 V1209502 HELD map03420,map03430 L helicase COG3973 Cluster_847898 V1209507 RNMV L Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) COG1658 Cluster_781015 V1209509 RPSN map03010 J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) COG0199 Cluster_625293 V1209513 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0847 Cluster_629004 V1209515 F Hydroxymethylpyrimidine transporter CytX COG1457 Cluster_741381 V1209517 GTF1 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) COG0438 Cluster_629005 V1209518 YTXK L Adenine-specific COG0827 Cluster_816831 V1209521 YBAK S YbaK ebsC protein COG2606 Cluster_629006 V1209523 L adenine specific DNA methyltransferase COG4889 Cluster_629007 V1209524 MVAK2 map00900,map01100,map01110 I Phosphomevalonate kinase COG1577 Cluster_708415 V1209525 PEPC E aminopeptidase c COG3579 Cluster_724832 V1209529 YKFB M mandelate racemase muconate lactonizing COG4948 Cluster_636851 V1209535 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_828454 V1209536 BL02899 K Transcriptional regulator COG1476 Cluster_632822 V1209538 MURE map00300,map00550 M mur ligase COG0769 Cluster_678555 V1209539 LMRA map02010 V ABC transporter COG1132 Cluster_636852 V1209540 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_724833 V1209541 M ErfK YbiS YcfS YnhG COG1376 Cluster_773570 V1209545 PSAA map02010 P ABC transporter COG0803 Cluster_636853 V1209546 NUSA K Transcription elongation factor NusA COG0195 Cluster_636854 V1209547 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_640884 V1209548 NPR P pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_640885 V1209550 YDIF S Abc transporter COG0488 Cluster_751459 V1209558 TRMD map00900,map01100,map01110 J Specifically methylates guanosine-37 in various tRNAs (By similarity) COG0336 Cluster_734640 V1209559 YLBM S UPF0348 protein COG1323 Cluster_644752 V1209562 YFMR S ABC transporter, ATP-binding protein COG0488 Cluster_644753 V1209567 PRFA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) COG0216 Cluster_687495 V1209569 GTFA map00500 G Sucrose phosphorylase COG0366 Cluster_875829 V1209571 S NA 0ZHU9 Cluster_777294 V1209575 LMRA map02010 V ABC transporter COG1132 Cluster_648810 V1209576 PIPD E Dipeptidase COG4690 Cluster_705298 V1209577 AVTA map00300,map01100,map01210,map01230 K Transcriptional regulator, GntR family COG1167 Cluster_652877 V1209579 SUN map00340,map00350,map00624,map01120 J NOL1 NOP2 sun family protein COG3270 Cluster_652878 V1209581 DLTA map00473,map05150 H Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) COG1020 Cluster_652879 V1209583 AZLC E azlc family COG1296 Cluster_652880 V1209585 MTNN map00270,map01100 F Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) COG0775 Cluster_699141 V1209587 CUDT P Transporter COG1292 Cluster_792936 V1209588 CJAA map02010,map02020 E ABC transporter substrate-binding protein COG0834 Cluster_657003 V1209592 TRXB map00240,map00450 C ferredoxin--nadp reductase COG0492 Cluster_657004 V1209593 SECA2 map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_721485 V1209602 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_665403 V1209603 GNTK map00030,map01100,map01110,map01120 G Gluconate kinase COG1070 Cluster_766150 V1209608 SP_1786 S Toxin-antitoxin system, antitoxin component, HicB family COG1598 Cluster_687496 V1209609 T metallophosphoesterase COG0639 Cluster_665405 V1209610 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_665406 V1209611 S Membrane COG4485 Cluster_884020 V1209613 YABO J s4 domain protein COG1188 Cluster_714910 V1209616 YSNB S Phosphodiesterase, mj0936 family COG0622 Cluster_674093 V1209631 DUSB J Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_674094 V1209634 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (alpha subunit) COG0587 Cluster_678556 V1209636 PANE1 map00770,map01100,map01110 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) COG1893 Cluster_674095 V1209637 CCA map03013,map03018 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate COG0617 Cluster_813038 V1209640 ASNA map00250,map00460,map00910,map01100,map01110,map01230 E asparagine synthetase A COG2502 Cluster_683092 V1209649 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase ii COG0046 Cluster_683093 V1209650 S Protein of unknown function (DUF1002) COG4086 Cluster_687497 V1209652 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_10543 V1209666 S NA 12A0K Cluster_30352 V1209667 GBS0396 map03070 U Pfam:TraG COG3505 Cluster_284476 V1209673 SRTB M (sortase) family COG3764 Cluster_47866 V1209674 GLVC map00010,map02060 G PTS System COG1264 Cluster_98433 V1209675 GABD map00250,map00350,map00650,map01100,map01120 C Dehydrogenase COG1012 Cluster_25413 V1209677 S Lpxtg-motif cell wall anchor domain protein 0Y44U Cluster_7526 V1209678 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_512431 V1209683 S Thioredoxin 0ZB1G Cluster_89505 V1209688 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_436924 V1209689 WANG_1264 L Transposase COG2452 Cluster_396544 V1209691 K transcriptional regulator COG0583 Cluster_407053 V1209692 S Major tail protein 0Y77V Cluster_366993 V1209693 S phage major capsid protein, HK97 family 0XTEI Cluster_360411 V1209694 I PAP2 Family COG0671 Cluster_120617 V1209696 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_813040 V1209698 MURP map00500,map00520,map02060 G pts system COG2190 Cluster_48070 V1209699 BGLF map00010,map00500,map00520,map02060 G pts system COG2190 Cluster_107047 V1209700 S NA 11VH8 Cluster_223148 V1209701 IUNH2 map00230,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_279053 V1209702 CAS1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) COG1518 Cluster_221967 V1209703 N, U Competence protein COG2804 Cluster_264342 V1209704 S hydrolase COG4814 Cluster_384093 V1209705 THIJ S intracellular protease Pfpi family COG0693 Cluster_206118 V1209708 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_440936 V1209709 LGAS_0572 L Integrase COG0582 Cluster_492101 V1209711 S Methyltransferase 11P8X Cluster_25899 V1209712 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_419705 V1209713 SP_1246 S Hydrolase COG0561 Cluster_195296 V1209715 S Toprim domain protein 0XSQN Cluster_471467 V1209716 S NA 11GVV Cluster_216124 V1209718 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_18206 V1209719 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_384094 V1209720 MECA O Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis COG4862 Cluster_477921 V1209722 MT2607 map00330,map00480,map01100,map01110 E decarboxylase COG1982 Cluster_347307 V1209723 O Matrixin COG5549 Cluster_112761 V1209724 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_227755 V1209725 RGG K Transcriptional regulator COG1396 Cluster_198881 V1209726 YLEB S Outer surface protein COG3589 Cluster_303658 V1209727 T protein tyrosine serine phosphatase COG2365 Cluster_272373 V1209728 CITM C Citrate transporter COG2851 Cluster_348929 V1209729 RSUA J Pseudouridine synthase COG1187 Cluster_766151 V1209730 YBHL S Membrane COG0670 Cluster_537289 V1209731 map00350,map00360,map00362,map00621,map00622,map01100,map01120 Q hydratase decarboxylase COG3971 Cluster_452918 V1209732 YMDB S appr-1-p processing domain protein COG2110 Cluster_357075 V1209733 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_387700 V1209734 S tpr repeat-containing protein 11U03 Cluster_407054 V1209735 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_197890 V1209736 MALF map02010 P permease protein COG1175 Cluster_75162 V1209738 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 Cluster_545917 V1209740 SP_0742 S degv family COG1307 Cluster_322942 V1209741 RECO map03440 L Involved in DNA repair and RecF pathway recombination (By similarity) COG1381 Cluster_189878 V1209745 CARA map00240,map00250,map01100 F carbamoyl-phosphate synthetase glutamine chain COG0505 Cluster_265667 V1209747 RLUD2 J pseudouridine synthase COG0564 Cluster_64839 V1209748 MNOD_0308 L Transposase COG3666 Cluster_45168 V1209750 S NA 11NI8 Cluster_636855 V1209751 S NA 102VM Cluster_161200 V1209752 SBND G Major Facilitator 0ZVCH Cluster_636856 V1209754 DNAB L replication initiation and membrane attachment protein COG3611 Cluster_353716 V1209755 AACC V aminoglycoside N(3)-acetyltransferase COG2746 Cluster_324520 V1209756 YUFN S basic membrane COG1744 Cluster_60139 V1209758 YKCB M glycosyl transferase, family 39 COG1807 Cluster_430949 V1209762 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0847 Cluster_300817 V1209764 YDIF S ABC transporter, ATP-binding protein COG0488 Cluster_182078 V1209765 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_417933 V1209770 SCRR K Sucrose operon repressor COG1609 Cluster_606753 V1209772 YBBR S ybbr family COG4856 Cluster_366994 V1209773 C Nitroreductase COG0778 Cluster_298173 V1209776 PI346 L dna replication protein COG1484 Cluster_79786 V1209779 M Cell surface protein 11GRZ Cluster_107627 V1209782 WANG_0286 L Transposase COG2801 Cluster_744670 V1209783 XSEB map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1722 Cluster_360413 V1209784 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_322943 V1209785 YIBF S multi-transmembrane protein COG5438 Cluster_368611 V1209787 TCYC map02010 E ABC transporter, ATP-binding protein COG1126 Cluster_291285 V1209789 K anti-repressor COG3645 Cluster_509852 V1209790 S Hydrolase COG4814 Cluster_319894 V1209791 S NA 0XNUC Cluster_310715 V1209794 CSHB map03018 L ATP-dependent RNA helicase COG0513 Cluster_332043 V1209796 MURG map00550,map01100,map04112 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) COG0707 Cluster_399987 V1209798 RSMC J methyltransferase COG2813 Cluster_554735 V1209799 THIN map00730,map01100 H thiamine COG1564 Cluster_169282 V1020801 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_86306 V1020802 XYLB map00040,map01100 G xylulokinase COG1070 Cluster_306286 V1020803 FEPC map02010 P ABC, transporter COG1120 Cluster_361654 V1020804 LSPA map03060 U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) 11G1Y Cluster_581977 V1020805 DKSA S DnaK suppressor protein 11IHW Cluster_536670 V1020806 BMUL_1742 S signal peptide protein COG4731 Cluster_266741 V1020807 S degv family COG1307 Cluster_412067 V1020808 RARA L recombination factor protein RarA COG2256 Cluster_307653 V1020809 S NA 0YWA6 Cluster_164344 V1020810 DXR map00900,map01100,map01110 I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) COG0743 Cluster_77439 V1020811 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_202718 V1020812 ACEE map00010,map00020,map00620,map00650,map01100,map01110,map01120 C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) COG2609 Cluster_77749 V1020813 P tonB-dependent Receptor COG4771 Cluster_177628 V1020814 SCLAV_2537 J methyltransferase COG2890 Cluster_595258 V1020817 S NA 0ZHU9 Cluster_244922 V1020818 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_743920 V1020819 S NA 0ZHU9 Cluster_270816 V1020820 FTSI map00550,map01100 M penicillin-binding protein COG0768 Cluster_339281 V1020824 K hemerythrin hhe cation binding domain protein 11HP7 Cluster_264080 V1020827 SSGB E HAD-superfamily subfamily IB hydrolase COG0560 Cluster_239636 V1020829 S Pfam:DUF1812 0Y61M Cluster_272113 V1020830 GLUD map02010 E amino acid AbC transporter COG0765 Cluster_572444 V1020833 RPSK map03010 J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) COG0100 Cluster_572445 V1020834 ANSA map00250,map00460,map00910,map01100,map01110 E L-asparaginase COG0252 Cluster_239637 V1020835 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Ribose-phosphate pyrophosphokinase COG0462 Cluster_428586 V1020836 TRPG map00230,map00400,map00983,map01100,map01110,map01230 E anthranilate synthase COG0512 Cluster_647917 V1020837 RLUC2 J pseudouridine synthase COG0564 Cluster_256226 V1020838 USPA1 T Universal stress protein COG0589 Cluster_79092 V1020839 SPEB S peptidase C10 11SDT Cluster_356750 V1020840 UREF O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) COG0830 Cluster_333239 V1020841 METI map02010 P ABC transporter, permease COG2011 Cluster_403185 V1020842 METN map02010 P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COG1135 Cluster_862952 V1020843 S NA 0ZHU9 Cluster_300549 V1020847 M NA 0ZYVM Cluster_188871 V1020848 S Terminase large subunit COG4626 Cluster_285631 V1020850 K Transcriptional regulator, ARAC family 125DJ Cluster_368316 V1020851 DNAQ2 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit epsilon COG0847 Cluster_551258 V1020852 S NA 0XQ6D Cluster_440530 V1020856 SBTA G Major Facilitator 0Y0M7 Cluster_213601 V1020857 AMD E amidohydrolase COG1473 Cluster_99399 V1020858 TNP7109-5 L transposase COG2801 Cluster_717495 V1020859 YLMG S integral membrane protein COG0762 Cluster_376672 V1020860 S DivIVA domain protein 11T6K Cluster_80096 V1020861 CYDC map02010 V ABC transporter COG1132 Cluster_218221 V1020862 FLUTA_0256 L Transposase COG3464 Cluster_196794 V1020863 ADH map00010,map00051,map00071,map00350,map00363,map00591,map00625,map00626,map00650,map00830,map00980,map00982,map01100,map01110,map01120 C alcohol dehydrogenase COG1063 Cluster_345415 V1020866 M N-Acetylmuramoyl-L-alanine amidase COG3023 Cluster_850824 V1020868 HSDR V Type I Restriction COG0610 Cluster_322670 V1020871 LACR K lactose phosphotransferase system repressor COG1349 Cluster_733923 V1020872 NPDA map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_381954 V1020873 RUVA map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) COG0632 Cluster_228719 V1020875 RLX U relaxase mobilization nuclease domain protein COG3843 Cluster_720769 V1020877 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_578758 V1020878 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_899570 V1020879 RLMB J RNA methyltransferase TrmH family group 3 COG0566 Cluster_244923 V1020880 V ABC superfamily ATP binding cassette transporter ABC protein COG1131 Cluster_506668 V1020881 SARZ K Transcriptional regulator 11TPH Cluster_94613 V1020883 MNHD P subunit D COG0651 Cluster_406706 V1020884 YCIO J sua5 ycio yrdc ywlc family protein COG0009 Cluster_360086 V1020894 S Membrane 129H3 Cluster_686553 V1020895 MJLS_1669 L transposase, IS3 IS911 family protein COG2963 Cluster_281465 V1020896 AARI_35290 L integrase catalytic COG2801 Cluster_482155 V1020897 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_390811 V1020898 AHPC O C-terminal domain of 1-Cys peroxiredoxin COG0450 Cluster_303368 V1020901 map02010 P ABC, transporter COG1120 Cluster_82058 V1020902 S Protein of unknown function (DUF1524) COG1479 Cluster_95110 V1020903 I, Q amp-dependent synthetase and ligase COG0318 Cluster_353442 V1020905 PHOB map02020 T Response regulator receiver domain protein COG0745 Cluster_389059 V1020906 HISB map00340,map01100,map01110,map01230 E imidazole-glycerol-phosphate dehydratase COG0131 Cluster_232204 V1020907 EXOA map03410 L Exodeoxyribonuclease III COG0708 Cluster_296559 V1020908 YBJI S Hydrolase COG0561 Cluster_136535 V1020909 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_421148 V1020910 YABB map00340,map00350,map00624,map01120 L Methyltransferase COG4123 Cluster_464686 V1020911 YAAT S psp1 domain protein COG1774 Cluster_566155 V1020912 LPRD K Lipoprotein lprD COG4578 Cluster_613263 V1020913 RV1342C S Membrane 1240U Cluster_270817 V1020914 SCLAV_3828 K deoR family transcriptional regulator COG1349 Cluster_710820 V1020916 RPOZ map00230,map00240,map01100,map03020 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) COG1758 Cluster_91773 V1020918 GABD2 map00250,map00350,map00650,map01100,map01120 C succinate-semialdehyde dehydrogenase COG1012 Cluster_799896 V1020921 TENI map00730,map01100 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) COG0352 Cluster_177629 V1020922 THIO map00730 E Glycine oxidase COG0665 Cluster_311979 V1020924 YBBP S TIGR00159 family COG1624 Cluster_318125 V1020925 NFSA map00051,map00190,map00363,map00591,map00625,map00633,map00650,map01100,map01120 C nitroreductase COG0778 Cluster_491592 V1020926 L Replication Protein COG5655 Cluster_432573 V1020927 L decarboxylase COG1611 Cluster_698508 V1020934 MENC map00130,map01100,map01110 H O-succinylbenzoate synthase COG4948 Cluster_217104 V1020935 MENB map00130,map00360,map01100,map01110,map01120 H Naphthoate synthase COG0447 Cluster_757732 V1020936 PDXY map00750,map01100 H functions in a salvage pathway. Uses pyridoxamine (By similarity) COG2240 Cluster_99400 V1020937 AMET_0415 S phage protein 0Y97T Cluster_376673 V1020943 NUDF map00230 F nudix hydrolase COG0494 Cluster_376674 V1020944 XERD L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_506669 V1020945 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_265425 V1020946 NIKC map02010 P ABC transporter (Permease COG1173 Cluster_799897 V1020947 YYZM S protein, conserved in bacteria COG4481 Cluster_183646 V1020948 YCHF J gtp-binding protein COG0012 Cluster_276143 V1020949 map00260,map00670,map00910,map01100 E Aminomethyltransferase folate-binding domain 0YP69 Cluster_548278 V1020950 J endoribonuclease L-psp COG0251 Cluster_304887 V1020951 MAZG map00230,map00240,map01100 F mazG family COG1694 Cluster_142649 V1020952 DAPE map00300,map00330,map01100,map01110,map01120,map01210,map01230 E Acetylornithine deacetylase COG0624 Cluster_804259 V1020955 SECE map03060,map03070 U Preprotein translocase SecE subunit 125W8 Cluster_444553 V1020956 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_643895 V1020958 S NA 0ZHU9 Cluster_426665 V1020959 MOAB2 H molybdenum cofactor biosynthesis protein COG0521 Cluster_631960 V1020961 S NA 11HBJ Cluster_899571 V1020962 S NA 0ZHU9 Cluster_613265 V1020963 CG2428 S rdd domain containing protein 11WIF Cluster_336279 V1020964 SCLAV_1126 map02010 V (ABC) transporter COG0842 Cluster_536671 V1020965 CTAA map00190,map00860,map01100,map01110,map02020 O cytochrome oxidase assembly COG1612 Cluster_808209 V1020966 S Zinc iron permease 127TF Cluster_647918 V1020967 CZRA K Transcriptional regulator, arsr family COG0640 Cluster_504187 V1020969 ZNTA P ATPase (EC 3.6.3.-) COG2217 Cluster_217105 V1020970 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_551260 V1020971 S Pfam:DUF299 0YNP9 Cluster_361655 V1020972 S NA 11YTD Cluster_808210 V1020973 LGAS_0607 T head morphogenesis protein, SPP1 gp7 COG5585 Cluster_269497 V1020975 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_673132 V1020981 L DNA binding protein, excisionase family 0YKT7 Cluster_299211 V1020982 AARI_35290 L integrase catalytic COG2801 Cluster_668865 V1020983 MJLS_1669 L transposase, IS3 IS911 family protein COG2963 Cluster_484462 V1020985 T serine threonine protein kinase COG0515 Cluster_444554 V1020990 S Domain of Unknown Function (DUF1599) 0XPSN Cluster_351758 V1020991 map02020 T Two component transcriptional regulator (Winged helix family COG0745 Cluster_155967 V1020992 M RHS repeat-associated core domain protein COG3209 Cluster_331777 V1020995 BTUF map02010 P Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) COG0614 Cluster_265426 V1020996 S NA 0XPA9 Cluster_86751 V1020997 map00550,map01100 M glycosyl transferase, family 51 COG0744 Cluster_153499 V1020999 PQQE K radical SAM domain protein COG0535 Cluster_337797 V1021000 RECO map03440 L Involved in DNA repair and RecF pathway recombination (By similarity) 0XR7P Cluster_444937 V1209802 ADHE map00010,map00051,map00071,map00350,map00362,map00363,map00591,map00620,map00621,map00622,map00625,map00626,map00650,map01100,map01110,map01120 C Dehydrogenase COG1454 Cluster_380542 V1209804 GLPG S Rhomboid family COG0705 Cluster_345738 V1209806 RPIA map00030,map00710,map01100,map01110,map01120,map01230 G phosphoriboisomerase A COG0120 Cluster_401775 V1209809 YCHF J gtp-binding protein COG0012 Cluster_218458 V1209811 ARGF map00330,map01100,map01110,map01230 E ornithine carbamoyltransferase COG0078 Cluster_557655 V1209812 map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020 C fumarate reductase flavoprotein, subunit COG1053 Cluster_728099 V1209814 S NA 0ZHU9 Cluster_692063 V1209815 ACYP map00620,map00627,map01120 C Acylphosphatase COG1254 Cluster_573168 V1209816 S NA 0YNCM Cluster_705300 V1209821 S Membrane 11YSX Cluster_336566 V1209826 YBJB S integral membrane protein COG4858 Cluster_198882 V1209827 TRMFO J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) COG1206 Cluster_186478 V1209828 S phage tape measure protein COG5283 Cluster_231256 V1209835 RPOD map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_399988 V1209837 S Lpxtg-motif cell wall anchor domain protein 0Y44U Cluster_417934 V1209839 M ErfK YbiS YcfS YnhG COG1376 Cluster_245144 V1209840 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_748034 V1209844 S NA 0ZHU9 Cluster_434879 V1209845 YTTB G Major Facilitator 0ZVV9 Cluster_237283 V1209847 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_237284 V1209851 YAGE E amino acid COG0531 Cluster_792937 V1209857 CPS1D map00051 S biosynthesis protein 0XQI4 Cluster_371943 V1209862 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_249040 V1209869 METY map00270,map01100 E o-acetylhomoserine COG2873 Cluster_333531 V1209876 GLNQ E abc transporter atp-binding protein COG1126 Cluster_387701 V1209877 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_287322 V1209880 LDB1874 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_272374 V1209882 RNY S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 Cluster_744673 V1209894 G Major Facilitator superfamily 0ZW4V Cluster_284477 V1209895 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_298174 V1209899 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_289973 V1209900 PIPD E Dipeptidase COG4690 Cluster_292645 V1209902 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_731400 V1209903 SP_1801 S integral membrane protein COG2261 Cluster_480337 V1209905 BLAI K Transcriptional regulator COG3682 Cluster_494583 V1209907 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_387702 V1209909 MDH map00051,map01100 E Dehydrogenase COG1063 Cluster_416135 V1209910 LEMA S LemA family COG1704 Cluster_352051 V1209911 S B3 4 domain protein COG3382 Cluster_306548 V1209913 M Sulfatase COG1368 Cluster_309278 V1209915 HTRA O serine protease COG0265 Cluster_657005 V1209917 S NA 0XNUC Cluster_509853 V1209918 S NA 0XNUC Cluster_401776 V1209919 K HTH_XRE 0XUC3 Cluster_504684 V1209920 NHAC map00680 C Na H antiporter COG1757 Cluster_758443 V1209921 V Inherit from COG: (ABC) transporter COG1131 Cluster_579483 V1209922 K Transcriptional regulator, GntR family COG1725 Cluster_342520 V1209926 COBQ S Glutamine amidotransferase COG3442 Cluster_316849 V1209928 G phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 COG2211 Cluster_432957 V1209933 S Cbs domain protein COG0517 Cluster_322944 V1209935 CPO S hydrolase COG0596 Cluster_475721 V1209938 S NA 0ZHU9 Cluster_484972 V1209939 S NA 0ZHU9 Cluster_458848 V1209940 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_471469 V1209943 S NA 0ZHU9 Cluster_414349 V1209946 S ABC transporter, ATP-binding protein COG0488 Cluster_477922 V1209949 NTH map03410 L endonuclease III COG0177 Cluster_338107 V1209950 PARC L DNA topoisomerase IV, subunit A COG0188 Cluster_339543 V1209952 PCPA map00051 S surface protein 11WKM Cluster_361980 V1209956 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_436925 V1209958 PSAA map02010 P ABC transporter COG0803 Cluster_711521 V1209963 S NA 0ZHU9 Cluster_350549 V1209965 MLER K malolactic fermentation system COG0583 Cluster_456880 V1209967 S Putative amino acid metabolism 122BZ Cluster_407055 V1209968 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_357076 V1209971 RIHB map00230,map00240,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_363550 V1209973 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_751462 V1209974 SCRK map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G fructokinase COG1940 Cluster_371944 V1209980 POTD map02010 E ABC transporter COG0687 Cluster_373556 V1209983 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_599578 V1209988 SP_0145 G Major Facilitator COG0477 Cluster_576390 V1209990 ARGG map00250,map00330,map01100,map01110,map01230 E Citrulline--aspartate ligase COG0137 Cluster_504685 V1209993 NRDI F NrdI protein COG1780 Cluster_385854 V1209994 SASC S surface protein 11FPX Cluster_499750 V1209996 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_748036 V1209997 S NA 0ZHU9 Cluster_610428 V1209998 ISPA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_394754 V1210005 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_542967 V1210006 S NA 11GVV Cluster_394755 V1210007 map03440 K Transcriptional regulator COG2865 Cluster_399990 V1210018 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase ii COG0046 Cluster_399991 V1210019 FABK map00061,map01100 I 2-Nitropropane dioxygenase COG2070 Cluster_401777 V1210020 map00052,map01100,map02060 G PTS system, galactitol-specific IIc component COG3775 Cluster_450966 V1210021 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_410667 V1210022 map03030 S Caulimovirus viroplasmin COG3341 Cluster_405364 V1210023 COABC map00770,map01100 H Phosphopantothenoylcysteine decarboxylase COG0452 Cluster_554736 V1210025 TRXB map00240,map00450 C ferredoxin--nadp reductase COG0492 Cluster_407056 V1210030 GEOTH_0480 L Integrase catalytic subunit COG4584 Cluster_425148 V1210032 PPIB O PPIases accelerate the folding of proteins COG0652 Cluster_816834 V1210036 S NA 0ZHU9 Cluster_410668 V1210040 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_531608 V1210044 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_419706 V1210049 COMEC S Competence protein COG2333 Cluster_419707 V1210050 CBPC M choline binding protein COG5263 Cluster_425149 V1210053 LYTS map02020 T Histidine kinase COG3275 Cluster_423364 V1210054 PBP2B map00550,map01100 M penicillin-binding protein COG0768 Cluster_573170 V1210055 YFNA E amino acid COG0531 Cluster_423365 V1210056 PYRP F permease COG2233 Cluster_450967 V1210062 RPSK map03010 J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) COG0100 Cluster_428972 V1210064 YCGA S c4-dicarboxylate anaerobic carrier COG1288 Cluster_428973 V1210066 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_430950 V1210068 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_471470 V1210071 S NA 11Z45 Cluster_537292 V1210080 ISPE map00900,map01100,map01110 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COG1947 Cluster_657006 V1210081 S Protein of unknown function (DUF1064) 0YJBM Cluster_475722 V1210082 YACL S PilT protein domain protein COG4956 Cluster_434880 V1210083 L Recombinase COG1961 Cluster_436926 V1210084 PEPV map00300,map00480,map01100,map01120,map01230 E Dipeptidase COG0624 Cluster_621504 V1210088 GPPA map00230 F, P ppx gppa phosphatase COG0248 Cluster_596064 V1210094 S NA 0ZHU9 Cluster_448997 V1210095 L adenine specific DNA methyltransferase COG4889 Cluster_446970 V1210097 PROC map00330,map01100,map01110,map01230 E pyrroline-5-carboxylate reductase COG0345 Cluster_640888 V1210101 DLTA map00473,map05150 H Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) COG1020 Cluster_452919 V1210105 TLYC P CBS domain protein COG1253 Cluster_528814 V1210113 S Uncharacterized conserved protein (DUF2075) COG3410 Cluster_458849 V1210114 S Membrane 0XQ5Q Cluster_458850 V1210116 RNJB map03018 O Metallo-Beta-Lactamase COG0595 Cluster_714914 V1210119 S Uncharacterized protein conserved in bacteria (DUF2252) COG4320 Cluster_892032 V1210120 GALM map00010,map01110,map01120 G converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) COG2017 Cluster_648812 V1210124 S Saccharopine dehydrogenase related protein 0XWVV Cluster_463019 V1210126 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_528815 V1210130 PYRF map00240,map01100 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) COG0284 Cluster_724837 V1210133 IOLS C aldo keto reductase COG0667 Cluster_467185 V1210135 MDH map00051,map01100 E Dehydrogenase COG1063 Cluster_471471 V1210142 YFHO S Membrane COG4485 Cluster_473582 V1210143 S NA 17M0X@proNOG Cluster_545920 V1210147 CADA P p-type atpase COG2217 Cluster_475723 V1210152 G Major Facilitator Superfamily 11M79 Cluster_475724 V1210154 S Membrane COG1434 Cluster_477923 V1210155 ARTM2 E amino acid AbC transporter COG0765 Cluster_477924 V1210157 HPK31 T Histidine kinase COG0642 Cluster_554737 V1210158 YAGE E amino acid COG0531 Cluster_477925 V1210159 C Inherit from bactNOG: reductase COG0656 Cluster_480338 V1210162 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_489602 V1210164 LPLA map00785,map01100 H Lipoate-protein, ligase COG0095 Cluster_480339 V1210167 NNRD G Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) COG0063 Cluster_548973 V1210170 MYCA S Myosin-Cross-Reactive Antigen COG4716 Cluster_515136 V1210171 AZLC E azlc family COG1296 Cluster_614065 V1210176 S NA 0ZHU9 Cluster_657007 V1210178 XSEB map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1722 Cluster_855459 V1210179 ISPA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_487248 V1210181 ARCD E Arginine ornithine antiporter COG0531 Cluster_489603 V1210182 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_687501 V1210183 S NA 0ZHU9 Cluster_489604 V1210186 SP_1529 M Polysaccharide Biosynthesis Protein COG2244 Cluster_492102 V1210188 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_744674 V1210189 MRED M Rod shape-determining protein MreD 1294E Cluster_569955 V1210194 ARCD S c4-dicarboxylate anaerobic carrier COG1288 Cluster_492104 V1210195 M Glycosyl transferase, family 2 COG1215 Cluster_621505 V1210198 S NA 0ZHU9 Cluster_809074 V1210200 K Transcriptional regulator COG1733 Cluster_497094 V1210201 S NA 11NI8 Cluster_499752 V1210203 YJEM E Inner membrane transporter yjeM 174IZ@proNOG Cluster_629008 V1210206 FLD C Flavodoxin COG0716 Cluster_504686 V1210208 SECA2 map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_560728 V1210212 RECG map03440 L ATP-dependent DNA helicase recG COG1200 Cluster_504688 V1210215 PEPN map00480,map01100 E Aminopeptidase COG0308 Cluster_512432 V1210224 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_512433 V1210226 TILS map00230,map00983,map01100,map01110 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) COG0037 Cluster_512434 V1210228 NHAC map00680 C Na H antiporter COG1757 Cluster_512436 V1210236 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_932015 V1210237 P Ion channel COG1226 Cluster_515137 V1210238 PRIA map03440 L Primosomal protein n' COG1198 Cluster_534390 V1210240 AZR S Nadph-dependent fmn reductase COG2461 Cluster_515138 V1210243 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_515139 V1210244 SUFD O feS assembly protein SufD COG0719 Cluster_531609 V1210245 TCYC map02010 E ABC transporter, ATP-binding protein COG1126 Cluster_528816 V1210252 YEBR T gaf domain protein COG1956 Cluster_517813 V1210253 GREA2 K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) COG0782 Cluster_636858 V1210256 map00300,map00330,map01100,map01110,map01120,map01210,map01230 E Acetylornithine deacetylase COG0624 Cluster_520358 V1210257 S Membrane COG0628 Cluster_523126 V1210260 HELD map03420,map03430 L helicase COG3973 Cluster_523127 V1210261 PTSI map00051,map01100,map02060 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) COG1080 Cluster_557657 V1210262 RPSK map03010 J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) COG0100 Cluster_523128 V1210263 CBPE map00500,map02020 M choline binding protein COG5263 Cluster_702231 V1210270 PPK map00190,map03018 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) COG0855 Cluster_528817 V1210275 YUNF S Conserved Protein COG1801 Cluster_528818 V1210276 LMRA map02010 V ABC transporter COG1132 Cluster_528819 V1210277 CELB map00052,map01100,map02060 G iic component COG1455 Cluster_528820 V1210281 MUTM map03410 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) COG0266 Cluster_534391 V1210287 NAPA2 P Na H antiporter COG0569 Cluster_534392 V1210291 FTSK D cell division protein FtsK COG1674 Cluster_537293 V1210293 MUTL map03430 L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) COG0323 Cluster_773571 V1210296 S Membrane COG0628 Cluster_813044 V1210299 S Hydrolase COG4814 Cluster_537295 V1210302 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_540096 V1210304 PSTS map02010,map02020,map05152 P phosphate COG0226 Cluster_632823 V1210305 SECA2 map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_540097 V1210310 LPLA map00785,map01100 H Lipoate-protein, ligase COG0095 Cluster_540098 V1210311 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_540099 V1210313 O Matrixin COG5549 Cluster_542969 V1210315 PEPX E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) 0XPUZ Cluster_542970 V1210316 T metallophosphoesterase COG0639 Cluster_545921 V1210320 S Inherit from NOG: domain protein 0XP4A Cluster_545922 V1210321 YHCG V abc transporter atp-binding protein COG1131 Cluster_545923 V1210322 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_545924 V1210324 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_579485 V1210330 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_548974 V1210331 GLNA map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG0174 Cluster_548975 V1210333 FTSW map04112 D cell division protein COG0772 Cluster_551878 V1210334 AZLC E azlc family COG1296 Cluster_551879 V1210336 SP_1245 S hydrolase COG0561 Cluster_554738 V1210341 TRMB C Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_554739 V1210342 G Major Facilitator 101QG Cluster_554740 V1210349 YFMM S ABC transporter, ATP-binding protein COG0488 Cluster_554742 V1210356 HASA M Glycosyl transferase, family 2 COG1215 Cluster_557658 V1210362 G Drug resistance transporter EmrB QacA 0XNN3 Cluster_678558 V1210364 G, K ROK family COG1940 Cluster_921357 V1210375 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_563673 V1210378 YAJC map03060,map03070 U preprotein translocase, subunit YajC COG1862 Cluster_563674 V1210379 LMRC map02010 V ABC transporter COG1132 Cluster_737941 V1210381 S NA 0ZBK7 Cluster_569956 V1210382 MURE map00300,map00550 M mur ligase COG0769 Cluster_569957 V1210386 map02020 V ABC transporter, permease COG0577 Cluster_573171 V1210387 RLUD J Pseudouridine synthase COG0564 Cluster_828460 V1210388 GLPT G transporter 0XPWC Cluster_699144 V1210389 S SAM-dependent methyltransferase 0YNVR Cluster_573172 V1210390 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_573173 V1210394 LACZ map00052,map00511,map00600,map01100 G beta-galactosidase COG3250 Cluster_836072 V1210396 PEPN map00480,map01100 E Aminopeptidase COG0308 Cluster_762185 V1210397 PEPN map00480,map01100 E Aminopeptidase COG0308 Cluster_576391 V1210399 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_576393 V1210404 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_824627 V1210405 LPCA M Glycosyl transferase family 8 COG1442 Cluster_576394 V1210406 YAGE E amino acid COG0531 Cluster_610429 V1210408 PBP2B map00550,map01100 M penicillin-binding protein COG0768 Cluster_579486 V1210410 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_705303 V1210411 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_582725 V1210413 YIBE S YibE F family protein COG5438 Cluster_582726 V1210414 LTRA S low temperature requirement protein COG4292 Cluster_585920 V1210422 S Membrane COG4485 Cluster_585921 V1210423 PEPX E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) 0XPUZ Cluster_805027 V1210428 YRFA K arsR family transcriptional regulator COG0640 Cluster_828462 V1210430 map00510,map01100 M Glycosyl Transferase COG0463 Cluster_871741 V1210431 YPHH map00362,map01100,map01120 S Cupin 2, conserved barrel domain protein COG1917 Cluster_589214 V1210437 COMF S Competence protein COG1040 Cluster_592589 V1210438 GALT map00052,map00520,map01100,map01110 G UDP-glucose-hexose-1-phosphate uridylyltransferase COG4468 Cluster_606754 V1210441 S Membrane COG4485 Cluster_592590 V1210443 GLNQ map02010 E abc transporter atp-binding protein COG1126 Cluster_629009 V1210444 MDH map00051,map01100 E Dehydrogenase COG1063 Cluster_596065 V1210449 GLNK map02020 T Histidine kinase COG0642 Cluster_632825 V1210451 TRML map04122 J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) COG0219 Cluster_683094 V1210452 S Fic/DOC family 0ZXM7 Cluster_828464 V1210455 XPT map00230,map01100,map01110 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) COG0503 Cluster_599580 V1210456 M phosphoglycerol transferase alkaline phosphatase superfamily protein COG1368 Cluster_603140 V1210458 PRKC T serine threonine protein kinase COG2815 Cluster_599581 V1210460 YUFN S basic membrane COG1744 Cluster_603141 V1210461 PSAA map02010 P ABC transporter COG0803 Cluster_632826 V1210462 RIBT S reductase 121UC Cluster_603142 V1210463 RIBF map00740,map01100 H riboflavin biosynthesis protein ribF COG0196 Cluster_603143 V1210464 GLPT G transporter 0XPWC Cluster_603144 V1210465 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_603145 V1210467 GPMA1 map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0588 Cluster_606755 V1210473 ARCD E Arginine ornithine antiporter COG0531 Cluster_724841 V1210478 LPLA map00785,map01100 H Lipoate-protein ligase COG0095 Cluster_702233 V1210480 CYDA map00190,map01100,map02020 C (Ubiquinol oxidase) subunit I COG1271 Cluster_606757 V1210481 CPS1C M polysaccharide biosynthesis protein COG2244 Cluster_748037 V1210482 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_610430 V1210486 PATA map00300,map01100,map01110,map01230 E Aminotransferase COG0436 Cluster_614067 V1210487 CELB map02060 G pts system 124SH Cluster_614068 V1210490 map03420 K, L transcription-repair coupling factor COG1197 Cluster_839927 V1210491 BL01171 P hemerythrin hhe cation binding domain protein COG2461 Cluster_728106 V1210493 E Peptidase family M20/M25/M40 COG2195 Cluster_714915 V1210496 SPXA K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) COG1393 Cluster_800792 V1210499 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_625296 V1210502 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (alpha subunit) COG0587 Cluster_621506 V1210503 YSLB S hydrocarbon binding protein 121J8 Cluster_708418 V1210505 S YGGT family COG0762 Cluster_625297 V1210508 S NA 0YNCM Cluster_731401 V1210509 S NA 0ZHU9 Cluster_708419 V1210510 DEOB map00030,map00230 G Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) COG1015 Cluster_871743 V1210511 S NA 11S7H Cluster_796907 V1210512 L DNA methylase COG0863 Cluster_629010 V1210513 RARA L recombination factor protein RarA COG2256 Cluster_629012 V1210515 S integral membrane protein COG0392 Cluster_629013 V1210516 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_832159 V1210517 S Protein of unknown function (DUF2922) 0XZ4F Cluster_629014 V1210518 map00240,map00250,map01100 E, F CPSase_sm_chain COG0505 Cluster_629016 V1210522 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_708420 V1210523 NDK map00230,map00240,map01100,map01110 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) COG0105 Cluster_632827 V1210524 PATA map00300,map01100,map01110,map01230 E Aminotransferase COG0436 Cluster_758448 V1210525 YYCI S YycI protein COG4853 Cluster_657010 V1210527 E Arginine ornithine antiporter COG0531 Cluster_816838 V1210528 MVK map00900,map01100,map01110,map04146 I mevalonate kinase COG1577 Cluster_636859 V1210529 GLTP C proton sodium-glutamate symport protein COG1301 Cluster_640889 V1210532 DEGV S degv family COG1307 Cluster_652883 V1210533 PSTB2 map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_644757 V1210539 L adenine specific DNA methyltransferase COG4889 Cluster_766155 V1210545 PARE L DNA topoisomerase IV (Subunit B) COG0187 Cluster_687503 V1210547 YJCE P Na H antiporter COG0025 Cluster_728107 V1210548 S tpr repeat-containing protein 11U03 Cluster_728108 V1210550 YJJP S Membrane COG2966 Cluster_652884 V1210554 OCAR_5722 G, M Nad-dependent epimerase dehydratase COG0702 Cluster_657011 V1210561 RES L resolvase COG1961 Cluster_661244 V1210565 GLNQ E abc transporter atp-binding protein COG1126 Cluster_661246 V1210567 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_777296 V1210573 V Beta-lactamase class C related penicillin binding protein COG1680 Cluster_674101 V1210579 TRMD map00900,map01100,map01110 J Specifically methylates guanosine-37 in various tRNAs (By similarity) COG0336 Cluster_674102 V1210581 PEPN map00480,map01100 E Aminopeptidase COG0308 Cluster_674103 V1210584 DIVIVA D Cell division protein DIVIVA COG3599 Cluster_674104 V1210585 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_674105 V1210587 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_741386 V1210591 PNB C Nitroreductase COG0778 Cluster_674106 V1210592 MUTS2 map03430 L muts2 protein COG1193 Cluster_683095 V1210597 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_203964 V1210611 OPPA E ABC transporter COG0747 Cluster_17494 V1210612 S Rib/alpha-like repeat 10008 Cluster_47693 V1210615 SP_1492 S cell wall surface anchor family protein 0YURI Cluster_484973 V1210631 S NA 0ZHU9 Cluster_135061 V1210633 DACA map00550,map01100 M carboxypeptidase COG1686 Cluster_652885 V1210634 S NA 0ZHU9 Cluster_669723 V1210636 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_548977 V1210642 YUFN S basic membrane COG1744 Cluster_855466 V1210671 S NA 0ZHU9 Cluster_737946 V1210675 S NA 0ZHU9 Cluster_566867 V1210682 GATB map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 Cluster_298175 V1210687 YHAM S Metal Dependent Phosphohydrolase COG3481 Cluster_428974 V1210695 S NA 0ZHU9 Cluster_380543 V1210699 TMK map00240,map01100 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) COG0125 Cluster_473583 V1210703 S NA 0ZHU9 Cluster_569959 V1210723 S NA 0ZHU9 Cluster_339544 V1210742 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_340994 V1210743 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_344109 V1210744 PEPC E aminopeptidase c COG3579 Cluster_748042 V1210751 RPLJ map03010 J 50s ribosomal protein L10 COG0244 Cluster_482648 V1210752 LYTR K TRANSCRIPTIONal COG1316 Cluster_355385 V1210753 C FMN-dependent alpha-hydroxy acid dehydrogenase COG1304 Cluster_361981 V1210756 PURB map00230,map00250,map01100,map01110 F adenylosuccinate lyase COG0015 Cluster_366995 V1210762 S NA 11NI8 Cluster_502296 V1210767 S NA 0Y2WH Cluster_731403 V1210768 YKCB M glycosyl transferase, family 39 COG1807 Cluster_640890 V1210797 YLBN S Nucleic acid-binding protein COG1399 Cluster_579489 V1210810 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_678562 V1210813 S NA 0Z01C Cluster_674107 V1210818 S NA 0ZHU9 Cluster_728111 V1210828 S NA 0ZHU9 Cluster_444938 V1210829 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (alpha subunit) COG0587 Cluster_661247 V1210831 S NA 0ZHU9 Cluster_640891 V1210856 S NA 0ZHU9 Cluster_721491 V1210884 SILP S secreted protein containing plastocyanin domain COG4633 Cluster_805033 V1210895 S NA 0ZHU9 Cluster_721493 V1210896 V prophage pi1 protein 32 COG1403 Cluster_492106 V1210897 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_515140 V1210919 POTA map02010 E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COG3842 Cluster_683096 V1210970 J acetyltransferase, (GNAT) family COG1670 Cluster_548978 V1210974 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_548979 V1210978 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_551881 V1210982 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_579491 V1211020 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_579492 V1211021 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_640893 V1211038 S NA 0ZHU9 Cluster_592591 V1211045 HELD map03420,map03430 L helicase COG3973 Cluster_603148 V1211064 MDLB map02010 V ABC transporter COG1132 Cluster_661248 V1211070 map00052,map01100,map02060 G PTS System COG3414 Cluster_661249 V1211121 G Drug resistance transporter EmrB QacA 0XNN3 Cluster_669725 V1211126 ATOB map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map02020 I Acetyl-CoA acetyltransferase COG0183 Cluster_678564 V1211128 METI map02010 P ABC transporter, permease COG2011 Cluster_687508 V1211140 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_23423 V1211145 S Lipase (class 3) 0ZJUJ Cluster_71824 V1211146 S Bacteriophage peptidoglycan hydrolase 0ZNE8 Cluster_361982 V1211150 SRTA M (sortase) family COG3764 Cluster_200882 V1211151 S NA 0Y8RQ Cluster_198883 V1211153 LGAS_0621 S Phage cell wall hydrolase 0XSRY Cluster_8092 V1211154 BL00969 S NA 0XYM3 Cluster_116280 V1211155 XKDK S phage protein 0XRSE Cluster_528821 V1211157 LGAS_0613 S phage protein 125MW Cluster_436927 V1211158 LGAS_0609 S Phage minor structural protein GP20 123J7 Cluster_103998 V1211159 LGAS_0606 S Phage Portal Protein 0XP33 Cluster_796912 V1211160 S NA 0Z156 Cluster_504689 V1211162 RUSA L endodeoxyribonuclease RusA COG4570 Cluster_322945 V1211163 K Phage antirepressor protein KilAC domain COG3645 Cluster_253992 V1211164 S NA 123QA Cluster_112 V1211165 S NA 120ST Cluster_13210 V1211166 S Inherit from NOG: LPXTG-motif cell wall anchor domain protein 0YEBJ Cluster_112035 V1211168 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_116993 V1211169 K, L domain protein COG0553 Cluster_499756 V1211170 S Phage-Associated Protein 120JX Cluster_669 V1211172 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_377042 V1211173 SP_0721 map02010 P transporter, permease 11MR9 Cluster_338108 V1211175 YDHQ K Transcriptional regulator COG2188 Cluster_43321 V1211176 FRUA map00051,map01100,map02060 G PTS System COG1445 Cluster_18131 V1211182 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_27271 V1211183 V Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) COG1136 Cluster_6317 V1211184 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_50573 V1211185 SP_0577 map00010,map00500,map00520,map02060 G pts system COG2190 Cluster_336567 V1211186 CPHY_2173 L Transposase 11J2V Cluster_378819 V1211187 PGM3 map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_520360 V1211188 S NA 11PZT Cluster_436928 V1211189 AZR S Nadph-dependent fmn reductase COG0431 Cluster_305163 V1211190 ZNUB map02010 P ABC, transporter COG1108 Cluster_176123 V1211191 S Minor capsid protein 0Y58E Cluster_72156 V1211192 S minor capsid protein 0XSIM Cluster_127486 V1211193 L Phage terminase, large subunit COG1783 Cluster_363552 V1211194 S NA 11XM2 Cluster_398270 V1211196 S Bacteriophage Gp15 protein 11NHP Cluster_253993 V1211198 BGLA1 map00010 G Glycosyl hydrolase family 1 COG2723 Cluster_14977 V1211199 M Phage minor structural protein COG4926 Cluster_74483 V1211200 GLNP E ABC transporter COG0834 Cluster_130333 V1211201 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_528822 V1211202 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_37951 V1211203 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_280356 V1211204 DPRA L DNA protecting protein DprA COG0758 Cluster_324521 V1211205 RNHB map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0164 Cluster_108178 V1211206 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_6893 V1211207 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_108179 V1211211 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_96806 V1211212 map00052,map01100,map02060 G PTS system, galactitol-specific IIc component COG3775 Cluster_56764 V1211213 C Fumarate reduCtase COG1053 Cluster_291286 V1211214 BL00871 S Phage tail protein 1222P Cluster_20222 V1211215 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_116281 V1211216 G Major Facilitator Superfamily 11M79 Cluster_272375 V1211218 map02010 P binding-protein-dependent transport systems inner membrane Component COG1175 Cluster_283105 V1211219 LACT K antiterminator COG3711 Cluster_65392 V1211220 LACE map00052,map01100,map02060 G pts system, lactose-specific COG1455 Cluster_101137 V1211221 LACG map00052,map01100 G Glycosyl hydrolase family 1 COG2723 Cluster_29571 V1211222 UVRD map03420,map03430 L ATP-dependent DNA helicase pcra COG0210 Cluster_579494 V1211223 ELI_1301 S Phage head-tail adaptor COG5614 Cluster_138234 V1211224 BL03502 O phage portal protein HK97 family COG4695 Cluster_97351 V1211227 YCAM E amino acid COG0531 Cluster_24282 V1211228 YFGQ P Cation-transporting atpase COG0474 Cluster_98434 V1211229 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_338109 V1211230 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_434881 V1211231 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_49365 V1211232 L SNF2 family DNA RNA helicase COG0553 Cluster_41518 V1211233 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_59585 V1211234 DXS map00730,map00900,map01100,map01110 H, I Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) COG1154 Cluster_130334 V1211235 PURB map00230,map00250,map01100,map01110 F adenylosuccinate lyase COG0015 Cluster_377043 V1211236 GLNP map02010 E amino acid AbC transporter COG0765 Cluster_460899 V1211237 RIMP S Required for maturation of 30S ribosomal subunits (By similarity) COG0779 Cluster_141988 V1211238 NUSA K Transcription elongation factor NusA COG0195 Cluster_421506 V1211239 K family Transcriptional regulator 0XUC3 Cluster_245145 V1211240 DACA map00550,map01100 M carboxypeptidase COG1686 Cluster_151213 V1211241 SBND G Major Facilitator 0ZVCH Cluster_96286 V1211246 LACG map00052,map01100 G Glycosyl hydrolase family 1 COG2723 Cluster_262959 V1211248 L Site-specific recombinase COG1961 Cluster_207227 V1211249 PLSX map00561,map00564,map01100 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) COG0416 Cluster_205039 V1211250 OPPD E, P ABC transporter COG0444 Cluster_384095 V1211251 RIBU S Membrane COG3601 Cluster_73511 V1211254 RNY S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 Cluster_111428 V1211255 S integral membrane protein 0XS1S Cluster_127487 V1211256 YDAM map00051,map00561,map01100 M Glycosyl transferase, family 2 COG1215 Cluster_272376 V1211257 EPSV M glycosyltransferase group 2 family protein COG0463 Cluster_35706 V1211258 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_380544 V1211261 S CAAX amino terminal protease family protein 0XUJM Cluster_237285 V1211265 LYSA2 M Glyco_25 COG3757 Cluster_110738 V1211268 TLYC P CBS domain protein COG1253 Cluster_582730 V1211273 PTHA map00051,map02060 G PTS system glucitol sorbitol-specific 1253B Cluster_207228 V1211274 YKGB map00030,map01100,map01110,map01120 G 6-phosphogluconolactonase (EC 3.1.1.31) COG2706 Cluster_339545 V1211275 L Membrane COG4905 Cluster_245146 V1211276 LSA_08620 S Lysm domain protein 11U6T Cluster_21221 V1211279 PEPN map00480,map01100 E Aminopeptidase COG0308 Cluster_49366 V1211280 ELI_1296 L Terminase, large subunit COG4626 Cluster_264345 V1211281 YQHA G aldose 1-epimerase COG2017 Cluster_156098 V1211284 S Phage Portal Protein COG4695 Cluster_347308 V1211285 map04112 O ATP-dependent Clp protease, proteolytic subunit COG0740 Cluster_195297 V1211286 GPSA map00564 C NADPH-dependent glycerol-3-phosphate dehydrogenase COG0240 Cluster_284478 V1211287 LGT M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 Cluster_592592 V1211292 RBFA J Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) COG0858 Cluster_250304 V1211293 APPC map02010 P ABC superfamily ATP binding cassette transporter ABC protein COG1173 Cluster_55242 V1211294 C NADPH-dependent FMN reductase COG1053 Cluster_224321 V1211301 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_332044 V1211302 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_139779 V1211304 YPIA S TPR repeat-containing protein COG0457 Cluster_322946 V1211307 LGG_01039 M Lyzozyme M1 (1,4-beta-N-acetylmuramidase) COG3757 Cluster_124743 V1211308 UMUC L ImpB MucB SamB family protein COG0389 Cluster_149585 V1211313 PLNI S CAAX amino terminal protease family 0XW1D Cluster_621510 V1211314 TRXA O Thioredoxin COG0526 Cluster_116282 V1211322 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_665412 V1211323 S NA 0ZHU9 Cluster_45567 V1211327 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_392949 V1211328 RELA map00230 S RelA SpoT domain protein COG2357 Cluster_352052 V1211330 S NA 0ZHU9 Cluster_427084 V1211332 K transcriptional regulator 0ZMZA Cluster_129609 V1211334 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_230084 V1211335 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG2176 Cluster_107629 V1211337 G Major Facilitator 0ZXAG Cluster_330480 V1211339 COMEA L Competence protein COG1555 Cluster_176124 V1211343 L Integrase COG0582 Cluster_260341 V1211344 YPJC S YitT family COG1284 Cluster_85910 V1211345 ATPA map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_683098 V1211347 S NA 0ZHU9 Cluster_512437 V1211349 S GtrA-like protein 0XV3V Cluster_252734 V1211358 GALU map00040,map00052,map00500,map00520,map01100,map01110 M UTP-glucose-1-phosphate uridylyltransferase COG1210 Cluster_101697 V1211359 PIPD E Dipeptidase COG4690 Cluster_257712 V1211362 YPBG map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G, K ROK family COG1940 Cluster_164486 V1211365 RECX map00561,map01100 M Glycosyl transferase (Group 1 COG0438 Cluster_344110 V1211366 NRDG O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) COG0602 Cluster_306549 V1211367 LGAS_0585 K phage anti-repressor protein COG3561 Cluster_387703 V1211369 RBSU G Ribose uptake protein RbsU COG4975 Cluster_89056 V1211371 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_122149 V1211372 PYRP F permease COG2233 Cluster_155290 V1211373 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_711530 V1211374 S NA 0ZHU9 Cluster_380545 V1211375 G, M oxidoreductase COG0702 Cluster_79787 V1211377 map00230,map00240 F 2',3'-cyclic-nucleotide 2'-phosphodiesterase EC 3.1.4.16 COG0737 Cluster_153650 V1211380 YFDE C L-carnitine dehydratase bile acid-inducible protein F COG1804 Cluster_260342 V1211381 L Protein of unknown function (DUF1351) 0YIT0 Cluster_665413 V1211388 S NA 0ZHU9 Cluster_499757 V1211391 S NA 0XY0U Cluster_425150 V1211392 MT0709 K Transcriptional regulator 11WKC Cluster_238600 V1211394 LYSA2 M Glyco_25 COG3757 Cluster_427085 V1211397 WECD map00350,map00362,map00627,map00642,map00903,map01120 S -acetyltransferase 11PF0 Cluster_129610 V1211402 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_340995 V1211406 HLYB map02010,map03070,map05133 V ABC, transporter COG2274 Cluster_370327 V1211408 PHOP map02020 T Transcriptional regulatory protein, C terminal 11FPD Cluster_534395 V1211409 LACA map00052,map01100 G Galactose-6-phosphate isomerase subunit LacA COG0698 Cluster_236085 V1211411 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_412488 V1211412 SPRL S SprT-like COG3091 Cluster_438966 V1211415 PAIA map00350,map00362,map00627,map00642,map00903,map01120 K Protease synthase and sporulation negative regulatory protein pai 1 COG0454 Cluster_599583 V1211421 RSFS S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) COG0799 Cluster_275053 V1211422 ORF3 S degv family COG1307 Cluster_382311 V1211427 K transcriptional Regulator LysR family 11Z5Z Cluster_249041 V1211431 GLYQ map00970 J glycyl-tRNA synthetase, alpha subunit COG0752 Cluster_599584 V1211445 GALT map00052,map00520,map01100,map01110 G UDP-glucose-hexose-1-phosphate uridylyltransferase COG4468 Cluster_492107 V1211448 PTPA T Low molecular weight phosphotyrosine protein phosphatase COG0394 Cluster_289974 V1211454 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_132635 V1211458 HIPMA_0065 L Transposase COG3328 Cluster_805037 V1211461 S NA 0ZHU9 Cluster_373558 V1211467 PLSY map00561,map00564,map01100 S Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) COG0344 Cluster_161201 V1211472 ATOB map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map02020 I Acetyl-CoA acetyltransferase COG0183 Cluster_482649 V1211473 S NA 0ZHU9 Cluster_446971 V1211481 NNRE S Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity) 124BP Cluster_209395 V1211482 YABB map00340,map00350,map00624,map01120 L Methyltransferase COG4123 Cluster_489606 V1211485 SP_1996 T Universal stress protein COG0589 Cluster_452921 V1211487 S NA 0ZHU9 Cluster_385855 V1211520 map00564,map01100 I Phosphatase COG0671 Cluster_430952 V1211521 NUDF map00230 F nudix hydrolase COG0494 Cluster_391137 V1211522 MUTF map02010 V ABC transporter, ATP-binding protein COG1131 Cluster_401778 V1211523 K HTH_XRE COG1974 Cluster_202930 V1211528 S phage tape measure protein COG5283 Cluster_380546 V1211530 YTPR J TRNA binding domain protein COG0073 Cluster_528824 V1211537 S NA 11GVV Cluster_473585 V1211549 NRDR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) COG1327 Cluster_545925 V1211550 PSIE S phosphate-starvation-inducible protein PsiE COG3223 Cluster_458851 V1211551 WECD map00350,map00362,map00627,map00642,map00903,map01120 S -acetyltransferase 11PF0 Cluster_728114 V1211563 S NA 0ZHU9 Cluster_385856 V1211575 S Acetyltransferase (GNAT) family 0XV0I Cluster_446972 V1211581 S NA 0ZHU9 Cluster_276387 V1211603 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_748048 V1211604 S NA 11GVV Cluster_405366 V1211620 MURF map00300,map00550,map01100 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) COG0770 Cluster_661251 V1211627 S NA 0ZHU9 Cluster_394756 V1211660 S NA 0ZHU9 Cluster_306550 V1211666 CPDA F serine threonine protein phosphatase COG1409 Cluster_456881 V1211680 S MutT NUDIX family protein 11JZT Cluster_427086 V1211718 LEPB map03060 U Signal peptidase i COG0681 Cluster_454944 V1211724 S NA 0ZHU9 Cluster_744689 V1211726 S NA 0ZHU9 Cluster_871757 V1211739 S NA 0ZHU9 Cluster_456882 V1211759 HSLV O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) COG5405 Cluster_399992 V1211760 PLSC map00561,map00564,map01100 I Acyl-transferase COG0204 Cluster_385857 V1211761 L decarboxylase COG1611 Cluster_748050 V1211768 S NA 0ZHU9 Cluster_432960 V1211777 YJDF S NA 11P5R Cluster_124625 V1021001 NAGB map00520,map01100,map01110 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COG0363 Cluster_542255 V1021002 SAFC map00340,map00350,map00624,map01120 S O-methyltransferase COG4122 Cluster_93210 V1021006 PYKF4 map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG0469 Cluster_747351 V1021009 XTHA map03410 L Exodeoxyribonuclease III COG0708 Cluster_788389 V1021011 K acetyltransferase COG0454 Cluster_351759 V1021014 CG2376 S NA 0XX45 Cluster_328829 V1021015 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_179343 V1021016 DALK_0234 L Transposase (IS4 family) protein COG3385 Cluster_340735 V1021017 ASPB E Aminotransferase COG0436 Cluster_278835 V1021018 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_403186 V1021023 L resolvase COG1961 Cluster_319660 V1021025 S NA 11JB6 Cluster_560062 V1021026 BIOC map00780,map01100 H Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) 11P8N Cluster_203745 V1021027 O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG0526 Cluster_158517 V1021032 YAGA L Integrase catalytic subunit 0XTHD Cluster_321094 V1021035 SCAD N, U domain protein COG3942 Cluster_89893 V1021040 RECG map03420,map03440 L transcriptioN-repair coupling factor COG1197 Cluster_823816 V1021041 RPSZ map03010 J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) COG0199 Cluster_444555 V1021042 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_101039 V1021043 P Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) COG4206 Cluster_213602 V1021044 map00240,map00250,map01100 E, F Carbamoyl phosphate synthase-like protein COG0458 Cluster_854692 V1021045 S conjugation system ATPase, TraG family 0XSHU Cluster_309019 V1021046 LTRA L reverse transcriptase COG3344 Cluster_346971 V1021048 S NA 100SX Cluster_155968 V1021049 YKNZ V ABC transporter, permease COG0577 Cluster_462584 V1021050 PABB F Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_450564 V1021055 S Cupin domain 122JN Cluster_280104 V1021060 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_462585 V1021062 S NA 0ZHE8 Cluster_333241 V1021065 K Transcriptional Regulator AraC Family 0Z5N2 Cluster_103892 V1021066 DPPA map02010 E ABC transporter substrate-binding protein COG4166 Cluster_404971 V1021067 S NA 0ZFZE Cluster_482156 V1021068 K RNA polymerase COG1595 Cluster_92283 V1021069 ACEE map00010,map00020,map00620,map00650,map01100,map01110,map01120 C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) COG2609 Cluster_353443 V1021070 YOQW S Conserved protein COG2135 Cluster_373253 V1021071 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_257469 V1021075 S Mammalian cell entry related domain protein 0YWNZ Cluster_808211 V1021076 S NA 11EN1 Cluster_175180 V1021079 PLDB map00561,map00564,map01100,map04723 I Alpha Beta Hydrolase Fold protein COG2267 Cluster_757733 V1021081 YAAA S S4 domain protein YaaA COG2501 Cluster_387324 V1021082 CCH L SCCmec staphylococcal cassette region, isolate CMFT106 COG5519 Cluster_714231 V1021083 CCRA L Cassette chromosome recombinase A COG1961 Cluster_838987 V1021084 S Zinc iron permease 127TF Cluster_496543 V1021085 GREA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) COG0782 Cluster_656168 V1021086 P transport system permease protein COG1173 Cluster_192441 V1021087 E ABC transporter substrate-binding protein COG0747 Cluster_342220 V1021088 FTSE map02010 D Cell division ATP-binding protein ftsE COG2884 Cluster_489067 V1021089 S Helix-turn-helix 102BD Cluster_380171 V1021090 S NA 0ZP1D Cluster_470993 V1021091 LSPA map03060 U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) COG0597 Cluster_240923 V1021092 HUTG map00330,map00340,map01100 E formiminoglutamate hydrolase COG0010 Cluster_221783 V1021093 MUTT1 L NUDIX hydrolase COG0494 Cluster_704619 V1021095 VAPD S Virulence-associated protein D COG3309 Cluster_199687 V1021098 GALM map00010,map01110,map01120 G converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) COG2017 Cluster_440531 V1021099 GPO map00480,map00590 O Glutathione peroxidase COG0386 Cluster_714232 V1021100 HUP L DNA-binding protein COG0776 Cluster_776535 V1021103 INFA J however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) COG0361 Cluster_595260 V1021104 RPSM map03010 J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits COG0099 Cluster_673134 V1021105 RPSK map03010 J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) COG0100 Cluster_234681 V1021106 M Transglycosylase COG5009 Cluster_371632 V1021112 YRBE Q ABC superfamily ATP binding cassette transporter permease protein COG0767 Cluster_324228 V1021113 FAT map00061,map01100 I Acyl-ACP thioesterase COG3884 Cluster_94084 V1021114 S NA 0Y4CP Cluster_691176 V1021115 SDHC map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120 C cytochrome b subunit 0YBKA Cluster_776536 V1021116 RV1590 S positive regulation by symbiont of host immune response 0XTWK Cluster_351760 V1021118 HISH map00340,map01100,map01110,map01230 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) COG0118 Cluster_772716 V1021119 T Protein tyrosine phosphatase COG0394 Cluster_114770 V1021121 L integrase family 112QY Cluster_799898 V1021125 S NA 0ZHU9 Cluster_94085 V1021129 FAS map00061,map00350,map00362,map00627,map00642,map00903,map01100,map01120 I synthase COG4982 Cluster_131742 V1021130 L Integrase COG4974 Cluster_136536 V1021131 S spore coat protein CotH 0YUJE Cluster_116903 V1021132 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_704620 V1021135 S NA 0ZHU9 Cluster_780089 V1021137 RPMC map03010 J 50s ribosomal protein l29 COG0255 Cluster_595261 V1021138 RPLN map03010 J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) COG0093 Cluster_639974 V1021139 RPLX map03010 J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) COG0198 Cluster_415801 V1021141 DNAQ2 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0847 Cluster_224123 V1021142 IDSA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_566156 V1021143 TATD L Hydrolase, tatD family COG0084 Cluster_139646 V1021144 PGN_0948 S NA 0Z217 Cluster_761330 V1021146 GLUP G transporter COG0738 Cluster_292369 V1021147 K Transcriptional regulator, MarR family 0XUB6 Cluster_180167 V1021148 S NA 122PE Cluster_635912 V1021149 CP_1013 map00520,map01100,map01110 G UTP-glucose-1-phosphate uridylyltransferase COG4284 Cluster_460462 V1021150 YDJM S Membrane-bound metal-dependent hydrolase COG1988 Cluster_717496 V1021151 S UPF0457 protein 0Z1YI Cluster_231051 V1021152 XERD L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_135735 V1021153 AMTB P ammonium transporter 0XNMH Cluster_293747 V1021154 S NA 11Z9D Cluster_452516 V1021155 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_215941 V1021156 O AhpC Tsa family 0YT1V Cluster_211386 V1021157 COBG map00860,map01100 H precorrin-3b synthase COG0155 Cluster_717497 V1021159 S ParB-like nuclease domain 0ZJMC Cluster_117588 V1021162 TNP3508A L Transposase COG3328 Cluster_150299 V1021163 S Lipoprotein 0YP1K Cluster_350217 V1021164 CBIO map02010 P abc transporter COG1122 Cluster_595262 V1021165 BIOY map02010 S bioY protein COG1268 Cluster_695139 V1021167 map00051 M glycosyltransferase group 2 family protein COG0463 Cluster_278836 V1021168 M Glycosyl transferase, family 2 COG1216 Cluster_96190 V1021169 M Inherit from NOG: Polymorphic outer membrane protein 11KKP Cluster_419280 V1021170 PANE map00770,map01100,map01110 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) COG1893 Cluster_710821 V1021176 SP_0276 S addiction module toxin, RelE StbE family COG3041 Cluster_714233 V1021179 S NA 0ZDIF Cluster_557008 V1021181 BL02553 K Transcriptional regulator COG1959 Cluster_385504 V1021182 YWNB S Nad-dependent epimerase dehydratase COG2910 Cluster_399646 V1021184 S NA 17PP9@proNOG Cluster_557009 V1021185 S NA 17U78@proNOG Cluster_269498 V1021187 S NA 12026 Cluster_428587 V1021188 EFP J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) COG0231 Cluster_652004 V1021191 CKL_1885 S Protein of unknown function (DUF1064) 1251H Cluster_494045 V1021192 S Domain of unknown function (DUF1896) 0YBI2 Cluster_477454 V1021194 S hmm pf04634 0Y5PY Cluster_602315 V1021195 L Resolvase, N terminal domain COG1961 Cluster_150300 V1021197 TRPE map00400,map01100,map01110,map01230 E anthranilate synthase component i COG0147 Cluster_761331 V1021198 S NA 0ZHU9 Cluster_582734 V1211803 S NA 0ZHU9 Cluster_718172 V1211804 S NA 0ZHU9 Cluster_683101 V1211822 S NA 0ZHU9 Cluster_744691 V1211823 S NA 0ZHU9 Cluster_762194 V1211834 S NA 0ZHU9 Cluster_705313 V1211844 S NA 0ZHU9 Cluster_573177 V1211853 S NA 0ZHU9 Cluster_766164 V1211869 S NA 0ZHU9 Cluster_674112 V1211882 S NA 0ZHU9 Cluster_599586 V1211887 YUGI J RNA binding s1 domain protein COG1098 Cluster_614075 V1211891 YPHI S Antibiotic biosynthesis monooxygenase COG1359 Cluster_450968 V1211892 S NA 0ZHU9 Cluster_487250 V1211900 GREA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) COG0782 Cluster_520361 V1211934 S NA 0ZHU9 Cluster_859450 V1211937 S NA 0ZHU9 Cluster_452922 V1211944 S NA 11VH8 Cluster_473587 V1211964 S NA 0Z376 Cluster_636866 V1211984 S NA 0ZHU9 Cluster_648818 V1211990 S NA 0ZHU9 Cluster_674114 V1212002 S NA 185WP@proNOG Cluster_789167 V1212025 S NA 0ZHU9 Cluster_560731 V1212043 S NA 0ZHU9 Cluster_582736 V1212055 S NA 0ZHU9 Cluster_499759 V1212062 S NA 0ZHU9 Cluster_551883 V1212076 S NA 0ZHU9 Cluster_754924 V1212078 S NA 0ZHU9 Cluster_805046 V1212090 S NA 0ZHU9 Cluster_695877 V1212107 S NA 0ZHU9 Cluster_800816 V1212122 S NA 0ZHU9 Cluster_636867 V1212128 S NA 0ZHU9 Cluster_652896 V1212133 S NA 0ZHU9 Cluster_820638 V1212179 S NA 0ZHU9 Cluster_596071 V1212218 S NA 0ZHU9 Cluster_582739 V1212237 K lytTr DNA-binding domain protein 0XX0T Cluster_820639 V1212273 S NA 0ZHU9 Cluster_711536 V1212278 YPHH map00362,map01100,map01120 S Cupin 2, conserved barrel domain protein COG1917 Cluster_621514 V1212315 S Uncharacterized conserved protein (DUF2075) COG3410 Cluster_652898 V1212360 G Major Facilitator 0XPHU Cluster_492108 V1212416 S NA 11GVV Cluster_33753 V1212418 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_256431 V1212419 BMUL_0473 S ABC transporter, permease COG4120 Cluster_57021 V1212421 GLPQ map00564 C glycerophosphoryl diester phosphodiesterase COG4781 Cluster_377044 V1212427 ADK map00230,map00240,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_83004 V1212434 ARLS T Histidine kinase COG0642 Cluster_299457 V1212440 LGAS_0582 S Erf family 11KYA Cluster_824644 V1212458 S NA 0ZHU9 Cluster_74181 V1212471 DEXB map00052,map00500,map01100 G trehalose-6-phosphate hydrolase (EC 3.2.1.93) COG0366 Cluster_87259 V1212480 S surface protein 11NE4 Cluster_273703 V1212482 DKG map00051,map00363,map00591,map00625,map00650,map01100,map01120 C reductase COG0656 Cluster_345739 V1212487 YCLJ T response regulator COG0745 Cluster_523130 V1212492 S Acetyltransferase (GNAT) family COG2153 Cluster_446973 V1212503 PYRR map00240,map01100 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) COG2065 Cluster_259037 V1212510 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_711540 V1212511 S NA 0ZHU9 Cluster_489607 V1212521 NRDI F Probably involved in ribonucleotide reductase function (By similarity) COG1780 Cluster_238601 V1212536 DEGV S degv family COG1307 Cluster_392950 V1212540 S NA 0YNCM Cluster_375276 V1212545 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_361983 V1212547 S Cbs domain protein COG0517 Cluster_233688 V1212550 map02010 S ABC transporter COG4152 Cluster_146510 V1212570 M Cell surface protein 11GRZ Cluster_657020 V1212581 S NA 0ZHU9 Cluster_307859 V1212582 STRA J Aminoglycoside COG3231 Cluster_467190 V1212584 CORA P transporter COG0598 Cluster_162034 V1212586 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG2812 Cluster_427087 V1212593 map00350,map00362,map00627,map00642,map00903,map01120 S -acetyltransferase 11TPW Cluster_509859 V1212594 SMPB O Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) COG0691 Cluster_599590 V1212600 S NA 0ZHU9 Cluster_231257 V1212606 MALR K transcriptional regulator COG1609 Cluster_335033 V1212622 RSUA J Pseudouridine synthase COG1187 Cluster_859465 V1212634 S NA 0ZHU9 Cluster_220804 V1212651 CLPE O ATP-dependent clp protease, ATP-binding subunit COG0542 Cluster_540102 V1212658 S toxin secretion phage lysis holin COG4824 Cluster_225500 V1212665 POXB map00620,map01100 E acetolactate synthase COG0028 Cluster_744700 V1212680 S NA 0ZHU9 Cluster_534397 V1212703 S NA 0ZHU9 Cluster_678574 V1212744 S NA 0ZHU9 Cluster_884061 V1212753 S NA 0ZHU9 Cluster_796927 V1212754 S NA 0ZHU9 Cluster_714931 V1212772 S NA 0ZHU9 Cluster_569963 V1212777 K Transcriptional Regulator AraC Family COG2207 Cluster_436930 V1212785 BAS1404 M n-acetylmuramoyl-l-alanine amidase COG5632 Cluster_458853 V1212791 SARE_3718 S Terminase 11NCI Cluster_399993 V1212795 K HTH_XRE 0ZH40 Cluster_494588 V1212834 ECFA1 map02010 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates COG1122 Cluster_378820 V1212836 S NA 0ZHU9 Cluster_382312 V1212854 BL01893 T 2'-3'-cyclic nucleotide COG5324 Cluster_384096 V1212856 S NA 11UKT Cluster_391138 V1212869 S Lpxtg-motif cell wall anchor domain protein 0Y44U Cluster_454946 V1212870 APT map00230,map01100 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) COG0503 Cluster_724858 V1212872 S NA 0ZHU9 Cluster_394757 V1212876 BL00740 K transcriptional regulator 0XR9S Cluster_410669 V1212905 AMPC V Beta-lactamase COG1680 Cluster_465105 V1212918 TREC map00052,map00500,map01100 G trehalose-6-phosphate hydrolase (EC 3.2.1.93) COG0366 Cluster_687525 V1212942 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_512439 V1212952 S NA 0ZHU9 Cluster_748062 V1212955 S NA 0ZHU9 Cluster_438967 V1212969 S Membrane 123WC Cluster_507278 V1212973 S Gcn5-related n-acetyltransferase 1221G Cluster_528827 V1212984 GLPF G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) COG0580 Cluster_851710 V1212989 RPMH map03010 J 50S ribosomal protein l34 COG0230 Cluster_489608 V1213000 PEPC E aminopeptidase c COG3579 Cluster_526059 V1213002 S NA 0ZHU9 Cluster_678575 V1213003 S NA 0ZHU9 Cluster_551886 V1213019 S NA 0ZHU9 Cluster_465106 V1213026 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_636870 V1213038 NPR P pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_487251 V1213071 L terminase (Small subunit) COG3747 Cluster_721509 V1213075 S NA 0ZHU9 Cluster_702245 V1213079 K Transcriptional regulator 0Y1S3 Cluster_548980 V1213117 map00010,map00051,map00071,map00350,map00362,map00363,map00591,map00620,map00621,map00622,map00625,map00626,map00650,map00830,map00980,map00982,map01100,map01110,map01120 C Dehydrogenase COG1454 Cluster_512441 V1213126 S NA 0ZHU9 Cluster_512442 V1213130 MVAS map00072,map00280,map00650,map00900,map01100,map01110 I Hydroxymethylglutaryl-CoA synthase COG3425 Cluster_900513 V1213161 J EFG_IV COG0480 Cluster_579501 V1213163 NRDF map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_531613 V1213185 YJEM E Inner membrane transporter yjeM 174IZ@proNOG Cluster_573182 V1213275 SCPB K Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) COG1386 Cluster_576400 V1213288 TCTD map02020 T Two component transcriptional regulator (Winged helix family COG0745 Cluster_844027 V1213317 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_603156 V1213336 ACIN_0074 L Transposase COG3464 Cluster_796931 V1213346 S selenium-binding protein YdfZ 17N8C@proNOG Cluster_610434 V1213349 SRTA M (sortase) family COG3764 Cluster_839966 V1213359 S NA 0ZHU9 Cluster_621518 V1213371 GLNE O, T Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) COG1391 Cluster_820651 V1213387 GBRO_0040 L Transposase COG3464 Cluster_661259 V1213423 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_813076 V1213433 S NA 0ZHU9 Cluster_785177 V1213451 BGLF map00010,map00500,map00520,map02060 G pts system COG2190 Cluster_695888 V1213457 UDP map00230 S phosphorylase 11F11 Cluster_687527 V1213465 S NA 0XU1A Cluster_805058 V1213467 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_194414 V1213480 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_141989 V1213484 MALE map02010 G (ABC) transporter COG2182 Cluster_116283 V1213485 MALF map02010 P permease protein COG1175 Cluster_275054 V1213486 MALG map02010 P ABC transporter, permease COG3833 Cluster_252735 V1213489 DAGK I Diacylglycerol kinase COG1597 Cluster_37017 V1213492 MT2607 map00330,map00480,map01100,map01110 E decarboxylase COG1982 Cluster_434882 V1213493 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_408810 V1213494 S NA 0ZHU9 Cluster_55495 V1213495 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG2812 Cluster_134261 V1213497 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_47694 V1213498 M Cell surface protein 11GRZ Cluster_440938 V1213499 ATPH map00190,map00195,map01100 C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) COG0712 Cluster_545930 V1213504 RPSL map03010 J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) COG0048 Cluster_373560 V1213509 map00230,map00450,map00920,map01100,map01120 S (phospho)adenosine phosphosulfate reductase 17YKU@proNOG Cluster_338110 V1213511 YEAZ O Peptidase M22 Glycoprotease COG1214 Cluster_29442 V1213513 MAP2 map00500,map01100 G hydrolase family 65, central catalytic COG1554 Cluster_121387 V1213516 S Pfam:DUF1142 0YD7R Cluster_382313 V1213517 CUTC P copper homeostasis protein cutc COG3142 Cluster_164487 V1213519 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_246473 V1213527 YIHY S ribonuclease BN COG1295 Cluster_85534 V1213539 CELA map00010 G 6-phospho-beta-glucosidase (EC 3.2.1.86) COG2723 Cluster_265668 V1213546 K Transcriptional Regulator AraC Family COG2207 Cluster_233689 V1213552 LACC map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G tagatose-6-phosphate kinase COG1105 Cluster_69604 V1213556 MALL map00052,map00500,map01100 G trehalose-6-phosphate hydrolase (EC 3.2.1.93) COG0366 Cluster_603158 V1213558 S NA 0ZHU9 Cluster_57515 V1213559 OPPA E ABC transporter COG0747 Cluster_60647 V1213560 OPPA E ABC transporter COG0747 Cluster_430954 V1213588 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_473589 V1213590 NTD map00240 F Nucleoside deoxyribosyltransferase COG3613 Cluster_132636 V1213596 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_718179 V1213606 S NA 0ZHU9 Cluster_275055 V1213609 RSMI G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 Cluster_228937 V1213614 M Glycosyl transferase family 8 0Y03U Cluster_789183 V1213625 S NA 0ZHU9 Cluster_520362 V1213665 S NA 0ZHU9 Cluster_792966 V1213668 CSPA K Cold shock protein COG1278 Cluster_279054 V1213671 YBBP S TIGR00159 family COG1624 Cluster_428977 V1213693 HSDS1 V type I restriction-modification system COG0732 Cluster_394758 V1213694 LEXA K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) COG1974 Cluster_585929 V1213702 S NA 0ZHU9 Cluster_236086 V1213705 FBA map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01230 G Aldolase COG0191 Cluster_699159 V1213716 S NA 0ZHU9 Cluster_731429 V1213718 TRXA2 O Thioredoxin COG0526 Cluster_277693 V1213722 K transcriptional regulator COG1737 Cluster_711555 V1213739 S NA 0ZHU9 Cluster_758465 V1213740 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_563682 V1213742 S NA 17D58@proNOG Cluster_674123 V1213745 S Inherit from NOG: Toxin-antitoxin system, toxin component, RelE family 0Y0E0 Cluster_276144 V1021206 SCLAV_1731 S Protein of unknown function (DUF3097) 0XR3X Cluster_175181 V1021209 FADH map00633,map01120 C NADH flavin oxidoreductase NADH oxidase COG1902 Cluster_98324 V1021216 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_98855 V1021219 S NA 0YG6V Cluster_581978 V1021220 L resolvase COG1961 Cluster_346973 V1021222 M hydrolase, family 25 COG3757 Cluster_366687 V1021223 GLDA map02010 V ABC, transporter COG1131 Cluster_788390 V1021224 S NA 0ZHU9 Cluster_171001 V1021230 YDBM map00071,map00280,map00281,map00650,map00903,map01040,map01100,map01110 I acyl-CoA dehydrogenase 0XWKU Cluster_150301 V1021231 PRIA map03440 L Primosomal protein n' COG1198 Cluster_277457 V1021232 RARA L recombination factor protein RarA COG2256 Cluster_321095 V1021234 M Sortase family COG3764 Cluster_363226 V1021237 NHAA map00680 P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) COG3004 Cluster_624491 V1021238 WHIB3 K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) 11U54 Cluster_595263 V1021239 S NA 11M8V Cluster_578760 V1021241 RNPA J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) COG0594 Cluster_792156 V1021242 YIDD S Could be involved in insertion of integral membrane proteins into the membrane (By similarity) COG0759 Cluster_105705 V1021243 NIFJ map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map00910,map01100,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_101040 V1021252 L DNA helicase COG1112 Cluster_363227 V1021253 S NA 0XS0Q Cluster_269499 V1021257 YEGX M hydrolase, family 25 COG3757 Cluster_417561 V1021261 PNUC H Nicotinamide Mononucleotide Transporter COG3201 Cluster_100470 V1021262 KUP P Transport of potassium into the cell (By similarity) COG3158 Cluster_562962 V1021267 S Protein of unknown function (DUF3164) 11TRN Cluster_306287 V1021269 FTSE map02010 D Cell division ATP-binding protein ftsE COG2884 Cluster_413989 V1021273 TRAO S conjugative transposon protein TraO 0YB3M Cluster_394342 V1021274 TRAN S Conjugative transposon TraN protein 0XNQ2 Cluster_190610 V1021275 NUSA K Transcription elongation factor NusA COG0195 Cluster_128757 V1021279 ASPB K Transcriptional regulator COG1167 Cluster_102157 V1021280 ILVB map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E acetolactate synthase COG0028 Cluster_154316 V1021281 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_252485 V1021282 SCLAV_4612 D Chromosome partitioning ATPase COG0455 Cluster_816053 V1021283 ECHA3 map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120 I Enoyl-CoA hydratase COG1024 Cluster_887147 V1021284 THIS map04122 H Thiamine biosynthesis protein thiS 0ZZQD Cluster_136537 V1021285 THIO map00730 E glycine oxidase COG0665 Cluster_274820 V1021286 AASI_0159 L transposase is116 is110 is902 family COG3547 Cluster_343819 V1021287 RV2229C S Zn-ribbon protein possibly nucleic acid-binding COG1579 Cluster_181864 V1021288 ERYC E DegT DnrJ EryC1 StrS COG0399 Cluster_799899 V1021289 NQRD C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG1347 Cluster_403187 V1021290 NQRE C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG2209 Cluster_412068 V1021291 NQRF C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) COG2871 Cluster_406707 V1021292 P Chromate transport protein COG2059 Cluster_102708 V1021293 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_436500 V1021294 OMPH M outer membrane chaperone Skp (OmpH) 11GII Cluster_209200 V1021298 RV1480 S von Willebrand factor COG1721 Cluster_551261 V1021301 HSPR K merR family transcriptional Regulator COG0789 Cluster_115429 V1021302 GLPT map02020 G transporter COG2271 Cluster_591851 V1021304 SCLAV_4550 L UPF0102 protein COG0792 Cluster_609620 V1021305 GLTT E glutamate COG0786 Cluster_484464 V1021306 O Tryp_SPc 0YAAN Cluster_256227 V1021308 PPK2 map00190,map03018 L polyphosphate kinase 2 COG2326 Cluster_355032 V1021309 RLPA M rare lipoprotein A COG0797 Cluster_473119 V1021312 HYCH O formate hydrogenlyase maturation 11Q8X Cluster_235871 V1021317 AHCY map00270,map01100 H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) COG0499 Cluster_562963 V1021328 MT2225 S Membrane 124IY Cluster_366688 V1021329 YEGV G Kinase, PfkB family COG0524 Cluster_190611 V1021330 ADCA map02010 P periplasmic solute binding protein COG0803 Cluster_468886 V1021331 S Protein of unknown function (DUF3180) 11VVN Cluster_464687 V1021332 FOLK map00790,map01100 H 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase COG0801 Cluster_624492 V1021333 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_428588 V1021334 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_135736 V1021335 HEMG map00860,map01100,map01110 H Flavin containing amine oxidoreductase COG1232 Cluster_265427 V1021336 RLX U relaxase mobilization nuclease domain protein COG3843 Cluster_602317 V1021338 MOBC S mobilization protein 0YZDW Cluster_643896 V1021339 AROK map00400,map01100,map01110,map01230 E Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) COG0703 Cluster_174364 V1021340 S WD-40-like protein 0ZD2Z Cluster_217106 V1021341 map02010 V ABC-2 type transporter COG0842 Cluster_588479 V1021350 CMTB S esterase COG0627 Cluster_548281 V1021351 P transport system permease protein COG1173 Cluster_315019 V1021352 P transport system permease protein COG1173 Cluster_369973 V1021354 S hemolysin III COG1272 Cluster_106310 V1021356 S NA 0XRDA Cluster_364935 V1021357 CDHC S 3-keto-5-aminohexanoate cleavage enzyme COG3246 Cluster_118273 V1021358 GND map00030,map00480,map01100,map01110,map01120 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) COG0362 Cluster_220603 V1021359 BETA map00260,map01100 E Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) COG2303 Cluster_303369 V1021360 AARI_35290 L integrase catalytic COG2801 Cluster_107522 V1021362 MUTB map00280,map00630,map00640,map00720,map01100,map01120 I Methylmalonyl-coA mutase COG2185 Cluster_264081 V1021363 NADC map00760,map01100 H nicotinate-nucleotide pyrophosphorylase COG0157 Cluster_266742 V1021364 PURK map00230,map01100,map01110 F phosphoribosylaminoimidazole carboxylase atpase subunit COG0026 Cluster_156822 V1021365 S NA 11QWE Cluster_316581 V1021366 S Membrane COG1811 Cluster_454550 V1021368 S NA 0YG6V Cluster_635914 V1021370 YVDD L decarboxylase COG1611 Cluster_514523 V1021371 YQXD S UPF0178 protein COG1671 Cluster_479822 V1021372 ACCB map00061,map00253,map00620,map00640,map00720,map01100,map01110,map01120 I Acetyl-CoA carboxylase, biotin carboxyl carrier protein COG0511 Cluster_231052 V1021373 S NA 11IEF Cluster_595264 V1021375 S Membrane 0Y7CA Cluster_299212 V1021376 METX map00270,map00920,map01100 E Homoserine O-trans-acetylase COG2021 Cluster_181865 V1021377 IDSA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_253792 V1021378 M Glycosyl Transferase 11P3Q Cluster_486779 V1021379 M Polysaccharide Biosynthesis Protein COG2244 Cluster_691177 V1021380 S NA 0Z98M Cluster_754161 V1021382 SUHB map00521,map00562,map01100,map01110,map04070 G inositol monophosphatase COG0483 Cluster_660317 V1021384 TRXA O Thioredoxin COG0526 Cluster_862957 V1021386 PADR K Transcriptional regulator COG1695 Cluster_464688 V1021392 COBB map00860,map01100 H Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) COG1797 Cluster_358442 V1021393 MAQU_3187 L Integrase catalytic subunit COG4584 Cluster_322671 V1021394 LIN1243 S domain protein COG1235 Cluster_464689 V1021395 S NA 0ZI5S Cluster_109317 V1021397 S ragb susd domaiN-containing protein 0XQXG Cluster_161069 V1021400 AARI_34710 L Transposase for insertion sequence 11IYJ Cluster_484978 V1213825 U hydrolase, family 8 0Y1JM Cluster_851721 V1213826 S NA 0ZHU9 Cluster_721518 V1213828 S NA 0ZHU9 Cluster_766182 V1213829 S NA 0ZHU9 Cluster_718182 V1213858 S NA 0ZHU9 Cluster_582742 V1213874 MEPR K Transcriptional regulator 121PJ Cluster_744711 V1213884 S NA 0ZHU9 Cluster_576401 V1213901 S NA 0ZHU9 Cluster_340998 V1213911 GBS0396 map03070 U Pfam:TraG COG3505 Cluster_678579 V1213933 S NA 0ZHU9 Cluster_748070 V1213936 S NA 0ZHU9 Cluster_800843 V1213943 S NA 0ZHU9 Cluster_828496 V1213963 S NA 0ZHU9 Cluster_515146 V1213966 HIPMA_0065 L Transposase COG3328 Cluster_800844 V1213984 S NA 0ZHU9 Cluster_702249 V1213987 S NA 0ZHU9 Cluster_792968 V1213991 S NA 0ZHU9 Cluster_417935 V1213993 S NA 0ZHU9 Cluster_820663 V1214025 S NA 0ZHU9 Cluster_816869 V1214027 PNCA map00760,map01100 Q isochorismatase COG1335 Cluster_596081 V1214037 S Protein of unknown function (DUF1304) 0XV9E Cluster_844041 V1214044 S NA 0ZHU9 Cluster_644775 V1214046 S NA 0ZHU9 Cluster_603159 V1214049 S NA 0ZHU9 Cluster_781055 V1214064 S NA 0ZHU9 Cluster_446977 V1214076 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_526061 V1214090 SP_0161 K, T lytTr DNA-binding domain protein COG3279 Cluster_425153 V1214107 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_528830 V1214156 S NA 0ZHU9 Cluster_450973 V1214169 S NA 0ZHU9 Cluster_452925 V1214172 CADA P heavy metal translocating p-type ATPase COG2217 Cluster_800850 V1214196 S NA 0ZHU9 Cluster_781060 V1214211 S NA 0ZHU9 Cluster_900536 V1214250 S NA 0ZHU9 Cluster_699163 V1214253 S NA 0ZHU9 Cluster_859497 V1214259 ARLR map02020 T response regulator COG0745 Cluster_537301 V1214261 S NA 11GVV Cluster_744717 V1214318 S NA 0ZHU9 Cluster_758470 V1214414 S NA 17D58@proNOG Cluster_542979 V1214419 K Transcriptional regulator 0Y1S3 Cluster_762227 V1214465 S NA 0ZHU9 Cluster_702251 V1214479 S NA 0ZHU9 Cluster_579504 V1214488 PCKA map00010,map00020,map00620,map00710,map01100,map01110,map01120 C phosphoenolpyruvate carboxykinase 0XT66 Cluster_606766 V1214504 S NA 0ZHU9 Cluster_792973 V1214508 S NA 0ZHU9 Cluster_592598 V1214522 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_603164 V1214546 OGT L Methyltransferase COG0350 Cluster_836102 V1214577 S Gcn5-related n-acetyltransferase 1221G Cluster_892100 V1214581 S NA 0ZHU9 Cluster_629031 V1214583 L Nudix family COG0494 Cluster_728134 V1214599 S NA 0ZHU9 Cluster_669744 V1214644 MNAA map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_792976 V1214670 S NA 0ZHU9 Cluster_769944 V1214675 YJHA S Endonuclease Exonuclease phosphatase 0XNVA Cluster_395 V1214686 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_762231 V1214703 S NA 0ZHU9 Cluster_531614 V1214716 S NA 0ZHU9 Cluster_632848 V1214737 S NA 0ZHU9 Cluster_494594 V1214742 S NA 0ZHU9 Cluster_744720 V1214745 S NA 0ZHU9 Cluster_629032 V1214746 S NA 0ZHU9 Cluster_482652 V1214754 S NA 0ZHU9 Cluster_751495 V1214807 S NA 0ZHU9 Cluster_721523 V1214832 S NA 0ZHU9 Cluster_384097 V1214854 COBC map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_844050 V1214862 S NA 0ZHU9 Cluster_596084 V1214879 S NA 0ZHU9 Cluster_644777 V1214895 S NA 0ZHU9 Cluster_414352 V1214909 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_813096 V1214930 S NA 0ZHU9 Cluster_463022 V1214971 S NA 0ZP3E Cluster_839977 V1214994 S NA 17D58@proNOG Cluster_648823 V1215036 CLPC O ATP-dependent Clp protease ATP-binding subunit COG0542 Cluster_683107 V1215046 S NA 0ZHU9 Cluster_728137 V1215052 S NA 0ZHU9 Cluster_573183 V1215083 DEXB map00052,map00500,map01100 G alpha amylase, catalytic region COG0366 Cluster_569968 V1215124 M Cell surface protein 11GRZ Cluster_569969 V1215127 S NA 0ZHU9 Cluster_582745 V1215133 BL02952 S Membrane COG1434 Cluster_711566 V1215157 EF0078 map00051,map00520,map01100,map02060 G PTS System COG3715 Cluster_526062 V1215252 S NA 0ZHU9 Cluster_652914 V1215261 S NA 0ZHU9 Cluster_475727 V1215263 L Transposase 11M0T Cluster_131120 V1215286 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_168525 V1215290 S Acyltransferase family 11XA1 Cluster_805080 V1215291 S NA 0ZHU9 Cluster_692077 V1215300 RPLW map03010 J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) COG0089 Cluster_171965 V1215301 PURB map00230,map00250,map00362,map01100,map01110,map01120 F adenylosuccinate lyase COG0015 Cluster_548988 V1215303 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_289975 V1215312 AMAA map00360 E amidohydrolase COG1473 Cluster_243875 V1215327 4HBD map00650 C NAD-dependent 4-hydroxybutyrate dehydrogenase COG1454 Cluster_251525 V1215328 RODA map00550,map04112 D cell cycle protein COG0772 Cluster_785198 V1215330 GLF M udp-galactopyranose mutase COG0562 Cluster_357077 V1215331 M Glycosyl transferase family 2 COG0463 Cluster_603167 V1215335 S NA 0ZHU9 Cluster_606769 V1215337 S NA 0ZHU9 Cluster_687545 V1215340 MJLS_1669 L transposase, IS3 IS911 family protein COG2963 Cluster_640916 V1215341 S NA 0ZHU9 Cluster_280358 V1215344 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_407057 V1215350 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_296771 V1215353 DPRE1 C FAD linked oxidase domain protein COG0277 Cluster_329081 V1215363 S ApbE family 11H27 Cluster_315324 V1215368 S PAP2 superfamily 0XZ0P Cluster_326020 V1215374 DPPD E, P (ABC) transporter COG0444 Cluster_333532 V1215379 TGT J Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COG0343 Cluster_844055 V1215383 S NA 0YXS4 Cluster_589234 V1215386 U Type IV secretory pathway VirD4 COG3505 Cluster_523140 V1215387 SCLAV_1560 map02010 P ABC transporter COG1122 Cluster_758477 V1215388 BDP_1102 V abc transporter COG1136 Cluster_339546 V1215389 LYTR2 K TRANSCRIPTIONal COG1316 Cluster_875891 V1215392 YHAO L DNA repair exonuclease COG0420 Cluster_463023 V1215395 G glycoside hydrolase, family COG1626 Cluster_347311 V1215397 UDP map00230 S phosphorylase 11F11 Cluster_507279 V1215399 S NA 0ZHU9 Cluster_355387 V1215404 S NA 0ZHU9 Cluster_434883 V1215409 DARB map00061,map01100 I synthase III COG0332 Cluster_368612 V1215411 AMYE map02010 G solute-binding protein COG1653 Cluster_399994 V1215416 PIP S domain protein COG1511 Cluster_699172 V1215417 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_526063 V1215419 TATD L Hydrolase, tatD family COG0084 Cluster_705334 V1215420 J sua5 ycio yrdc ywlc family protein COG0009 Cluster_421508 V1215421 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_392952 V1215428 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_585931 V1215432 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_425154 V1215433 MT3543 S NA 11ISP Cluster_396545 V1215434 PIP map00330 L Prolyl aminopeptidase COG0596 Cluster_454949 V1215435 CSN1 V CRISPR-associated 10TRZ Cluster_896274 V1215438 S NA 0XY3U Cluster_408811 V1215452 RNC map03008,map05205 K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) COG0571 Cluster_484981 V1215455 DPS P During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction COG0783 Cluster_809121 V1215458 S NA 17D58@proNOG Cluster_416136 V1215460 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_417936 V1215462 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_523141 V1215463 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_423366 V1215474 S NA 126VW Cluster_428979 V1215485 V ABC, transporter COG0577 Cluster_428980 V1215486 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_428981 V1215488 GLF M udp-galactopyranose mutase COG0562 Cluster_434884 V1215493 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_517817 V1215494 PSTS2 map02010,map02020,map05152 P Phosphate-binding protein COG0226 Cluster_526064 V1215499 LYSC map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Aspartokinase COG0527 Cluster_440939 V1215500 KUP P Transport of potassium into the cell (By similarity) COG3158 Cluster_892120 V1215505 S NA 0ZCAU Cluster_440940 V1215507 MALQ map00500,map01100 G 4-alpha-glucanotransferase COG1640 Cluster_683113 V1215508 S radical SAM domain protein COG0641 Cluster_465107 V1215509 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_482654 V1215518 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_450975 V1215524 XERD L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_737997 V1215531 S Toxin-antitoxin system, toxin component, HicA family 126G5 Cluster_836114 V1215534 DPPD map02010 S ABC transporter COG1123 Cluster_460903 V1215538 S domain protein 0XNZW Cluster_863857 V1215541 S NA 0ZHU9 Cluster_480343 V1215547 S NA 0YNFS Cluster_582747 V1215554 M Transferase COG1216 Cluster_467191 V1215559 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins COG0706 Cluster_494595 V1215562 PURA map00230,map00250,map01100 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis COG0104 Cluster_471476 V1215573 G Aamy_C COG1523 Cluster_475728 V1215581 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_480344 V1215590 PTSG map00010,map00500,map00520,map02060 G PTS System COG1264 Cluster_652915 V1215593 MURF map00300,map00550,map01100 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) COG0770 Cluster_482655 V1215595 MRCB map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_504693 V1215597 RIHB map00230,map00240,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_484982 V1215600 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_669747 V1215603 S NA 0ZHU9 Cluster_545932 V1215607 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_489614 V1215608 PEPD E Dipeptidase COG4690 Cluster_769950 V1215610 GLUQ map00860,map00970,map01100,map01110 J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) COG0008 Cluster_494596 V1215613 ARGG map00250,map00330,map01100,map01110,map01230 E Citrulline--aspartate ligase COG0137 Cluster_557667 V1215626 FOLB map00790,map01100 H dihydroneopterin aldolase COG1539 Cluster_705336 V1215629 S ApbE family 11H27 Cluster_504694 V1215630 RND J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) COG0349 Cluster_504695 V1215636 UGPC map02010 G (ABC) transporter COG3839 Cluster_507280 V1215637 COBN map00860,map01100 H cobaltochelatase, cobn subunit COG1429 Cluster_563689 V1215640 UGD map00040,map00053,map00500,map00520,map01100,map01110 M UDP-glucose 6-dehydrogenase COG1004 Cluster_548989 V1215641 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_509865 V1215645 HOM map00260,map00270,map00300,map01100,map01110,map01120,map01230 E homoserine dehydrogenase COG0460 Cluster_512445 V1215646 DPPB map02010 P ABC transporter (Permease) COG0601 Cluster_515149 V1215650 FLUTA_0256 L Transposase COG3464 Cluster_754953 V1215653 ASPA map00250,map00910,map01100 E Aspartate ammonia-lyase COG1027 Cluster_683114 V1215665 S integral membrane protein 0XS1S Cluster_526065 V1215669 U relaxase mobilization nuclease domain protein COG3843 Cluster_526066 V1215672 S NA 0ZTYV Cluster_526067 V1215673 M Inherit from NOG: domain protein 18B9F@proNOG Cluster_741422 V1215674 S NA 11H00 Cluster_531615 V1215693 BT_0485 L transposase is116 is110 is902 family COG3547 Cluster_531616 V1215697 GLGB map00500,map01100,map01110 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) COG0296 Cluster_531617 V1215699 TIG O Peptidyl-prolyl cis-trans isomerase COG0545 Cluster_632854 V1215701 AMTB P ammonium transporter 0XNMH Cluster_534402 V1215703 M Inherit from NOG: domain protein 18B9F@proNOG Cluster_537303 V1215708 PBP2B map00550,map01100 M penicillin-binding protein COG0768 Cluster_540106 V1215709 map02010 P ABC transporter COG1122 Cluster_542982 V1215714 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_542983 V1215719 COAA map00770,map01100 H pantothenic acid kinase COG1072 Cluster_816892 V1215727 S NA 185WP@proNOG Cluster_625307 V1215728 ISPF map00900,map01100,map01110 I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) COG0245 Cluster_551888 V1215734 PURM map00230,map01100,map01110 F phosphoribosylaminoimidazole synthetase COG0150 Cluster_900564 V1215737 NOX map00190 P pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_606772 V1215742 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_705338 V1215748 LDTA S ErfK YbiS YcfS YnhG COG1376 Cluster_851739 V1215751 TRAN S Conjugative transposon TraN protein 0XNQ2 Cluster_557669 V1215756 MUTT1 L NUDIX hydrolase COG0494 Cluster_669748 V1215764 VEX1 V ABC transporter, permease COG0577 Cluster_563691 V1215765 AGCS E amino acid carrier protein COG1115 Cluster_563692 V1215766 TYRA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydrogenase COG0287 Cluster_731447 V1215776 RPLQ map03010 J 50S ribosomal protein l17 COG0203 Cluster_566885 V1215780 NOX map00190 P pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_569970 V1215783 S NA 0YESD Cluster_702257 V1215786 COMEC S ComEC Rec2-like protein COG0658 Cluster_762243 V1215788 S Inherit from NOG: Methyltransferase 0XSGP Cluster_576403 V1215792 S NA 0ZAU4 Cluster_687548 V1215794 RARA L recombination factor protein RarA COG2256 Cluster_576404 V1215799 DPPB map02010 P ABC transporter (Permease) COG0601 Cluster_576405 V1215800 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG0194 Cluster_219434 V1021403 FRUK-1 map00051 G 1-phosphofructokinase COG1105 Cluster_346974 V1021405 CSP1 M LGFP repeat COG5479 Cluster_110595 V1021406 SASC S surface protein 11FPX Cluster_426667 V1021407 S NA 126XC Cluster_147944 V1021408 L Inherit from COG: transposase COG3385 Cluster_525413 V1021409 SCRB map00052,map00500,map01100 G hydrolase COG1621 Cluster_496544 V1021410 SCRA map00500,map02060 G PTS system COG2190 Cluster_232205 V1021411 S NA 0Z51W Cluster_562964 V1021412 S NA 0ZMA4 Cluster_511884 V1021415 RPLI map03010 J Binds to the 23S rRNA (By similarity) COG0359 Cluster_227538 V1021417 P abc transporter atp-binding protein COG1116 Cluster_282845 V1021418 COMEA L Competence protein COG1555 Cluster_159370 V1021420 AARI_34710 L Transposase for insertion sequence 11IYJ Cluster_446572 V1021421 ATPH map00190,map00195,map01100 C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) COG0712 Cluster_530984 V1021422 S -acetyltransferase 0XYCF Cluster_788391 V1021423 S Protein of unknown function (DUF2582) 0XWWH Cluster_355033 V1021425 PSD map00564,map01100 I Phosphatidylserine decarboxylase proenzyme COG0688 Cluster_412069 V1021426 S conjugative transposon protein TraO 0YB3M Cluster_419281 V1021427 TRAN_2 S Conjugative transposon TraN protein 0XNQ2 Cluster_784344 V1021431 S NA 0XZ3Z Cluster_226421 V1021432 APEB E M18 family aminopeptidase COG1362 Cluster_202719 V1021433 PILB map03070 U type ii secretion system protein e COG2804 Cluster_160249 V1021434 S Membrane COG3949 Cluster_111935 V1021435 S NA 11TF5 Cluster_257470 V1021436 PHOH T Phoh family COG1702 Cluster_280105 V1021437 PHAB map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120 I Enoyl-CoA hydratase 0XTHX Cluster_336280 V1021440 L TatD family COG0084 Cluster_112632 V1021441 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_188003 V1021442 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_380172 V1021446 FLDA map00910,map01120 C Low-potential electron donor to a number of redox enzymes (By similarity) COG0716 Cluster_315020 V1021447 S Family of unknown function (DUF490) 0Z0C5 Cluster_406708 V1021448 M Outer membrane protein, OMP85 family 0XNPU Cluster_113359 V1021449 NIFJ map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map00910,map01100,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_113360 V1021450 S integral membrane protein 11VP2 Cluster_438550 V1021451 S NA 0YNYF Cluster_757734 V1021452 S NA 126R7 Cluster_113361 V1021453 map01054 Q synthetase COG1020 Cluster_195123 V1021455 HEMB map00860,map01100,map01110 H delta-aminolevulinic acid dehydratase COG0113 Cluster_887149 V1021456 HEMD map00860,map01100,map01110 H synthase COG1587 Cluster_385505 V1021457 GLTD map00250,map00910,map01100,map01110,map01120,map01230 E Glutamate synthase COG0493 Cluster_340736 V1021458 NIRK map00910,map01120 Q nitrite reductase COG2132 Cluster_120483 V1021468 V ABC transporter COG1132 Cluster_686557 V1021470 ECOLC_0728 L Transposase is3 is911 COG2963 Cluster_270818 V1021471 AVIN_16550 L Transposase COG2801 Cluster_168375 V1021474 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_698510 V1021475 M Glycosyl transferase, family 2 16QVP@proNOG Cluster_569251 V1021476 CSEE S NA 0XUV8 Cluster_276145 V1021477 RLUD2 J pseudouridine synthase COG0564 Cluster_396211 V1021478 RBSK map00030 G ribokinase COG0524 Cluster_199688 V1021479 map02010 P abc transporter COG1131 Cluster_210290 V1021480 SLGD_00086 S Ser Thr phosphatase family protein COG1409 Cluster_325727 V1021481 L DNA methylase n-4 n-6 domain protein COG0863 Cluster_595265 V1021482 RPLN map03010 J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) COG0093 Cluster_430574 V1021483 SIGM K RNA polymerase COG1595 Cluster_346975 V1021485 S Rhodanese-like domain 11QSF Cluster_528239 V1021487 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0847 Cluster_134933 V1021488 SP_1221 V restriction 0XQ8K Cluster_424782 V1021489 K Tetr family transcriptional regulator 11ZIV Cluster_602318 V1021490 S NA 11Z5A Cluster_292370 V1021494 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_322672 V1021495 YRBE Q ABC superfamily ATP binding cassette transporter permease protein COG0767 Cluster_260125 V1021496 S NA 0XZ8I Cluster_602319 V1021497 S rhodanese-like protein 0ZX1Q Cluster_156823 V1021499 SPL M NlpC/P60 family COG0791 Cluster_366689 V1021500 YDHK S (LipO)protein 11PEU Cluster_664520 V1021501 YEED O redox protein, regulator of disulfide bond formation COG0425 Cluster_299213 V1021502 S Inherit from NOG: antigen PG97 COG4886 Cluster_117589 V1021503 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_525414 V1021504 P transport protein COG2985 Cluster_390812 V1021505 S NA 0ZHU9 Cluster_244924 V1021506 S ErfK ybiS ycfS ynhG family protein 0ZJ65 Cluster_569252 V1021511 S NA 12B7K Cluster_311980 V1021512 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_639976 V1021513 K ArsR family transcriptional regulator COG0640 Cluster_128079 V1021514 SULP P sulfate transporter COG0659 Cluster_466707 V1021517 TRML map04122 J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) COG0219 Cluster_140374 V1021523 UGD map00040,map00053,map00500,map00520,map01100,map01110 M UDP-glucose 6-dehydrogenase COG1004 Cluster_204850 V1021525 CYDD map02010 V ABC, transporter COG4988 Cluster_635915 V1021526 YJJK S ABC transporter, ATP-binding protein COG0488 Cluster_432574 V1021527 map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_539528 V1021529 NDK map00230,map00240,map01100,map01110 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) COG0105 Cluster_462587 V1021530 S Membrane 12317 Cluster_306288 V1021531 L Dna topoisomerase COG0550 Cluster_430575 V1021532 MAF D MAF-like protein COG0424 Cluster_252486 V1021534 S NA 11R7X Cluster_345416 V1021535 V ABC transporter COG1136 Cluster_345417 V1021537 S abc transporter atp-binding protein 11HXT Cluster_373254 V1021539 PURE map00230,map01100,map01110 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) COG0041 Cluster_145578 V1021540 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_296560 V1021541 L DNA Methylase COG2189 Cluster_264082 V1021545 L UvrD REP helicase COG1074 Cluster_121999 V1021546 S NA 0Z4Z7 Cluster_536673 V1021548 S NA 122DJ Cluster_473120 V1021550 S NA 12D6S Cluster_656169 V1021552 S Toxin-antitoxin system, toxin component, RelE family 122IP Cluster_260126 V1021555 ADCA map02010 P periplasmic solute binding protein COG0803 Cluster_122703 V1021556 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_210291 V1021557 map00860,map01100 H Precorrin-6y C5,15-methyltransferase COG2242 Cluster_243646 V1021564 TIG O Peptidyl-prolyl cis-trans isomerase COG0545 Cluster_123339 V1021565 YPWA E carboxy-peptidase COG2317 Cluster_462588 V1021566 L helicase COG1061 Cluster_727357 V1021568 S Inherit from COG: Virulence-associated protein e COG5545 Cluster_484465 V1021570 ARGB map00330,map01100,map01110,map01210,map01230 E nag kinase COG0548 Cluster_299214 V1021571 ARGD map00300,map00330,map01100,map01110,map01120,map01210,map01230 E acetylornithine aminotransferase COG4992 Cluster_152736 V1021572 S NA 0Z9TI Cluster_152737 V1021573 F Uracil permease COG2233 Cluster_225294 V1021574 V Type I restriction modification DNA specificity domain 0ZKBR Cluster_609621 V1021575 RPSP map03010 J 30s ribosomal protein S16 COG0228 Cluster_123340 V1021576 S NA 11JP6 Cluster_545239 V1021577 S NA 0YIEB Cluster_740683 V1021581 ZNTA P ATPase (EC 3.6.3.-) COG2217 Cluster_193277 V1021582 S Acyl-transferase 128XF Cluster_819696 V1021584 S NA 0ZHU9 Cluster_211387 V1021589 GND map00030,map00480,map01100,map01110,map01120 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) COG0362 Cluster_257471 V1021590 GLUQ map00860,map00970,map01100,map01110 J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) COG0008 Cluster_156824 V1021597 ORF028 S NA 0ZZ9R Cluster_125293 V1021599 EXPZ S ABC transporter, ATP-binding protein COG0488 Cluster_276146 V1021600 RRMJ J Hemolysin A COG1189 Cluster_629033 V1215805 XPT map00230,map01100,map01110 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) COG0503 Cluster_576406 V1215806 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_579508 V1215808 MOXR S Atpase associated with various cellular activities aaa_3 COG0714 Cluster_576407 V1215810 PEPN map00480,map01100 E aminopeptidase N COG0308 Cluster_579509 V1215812 RV1825 S Bacterial protein of unknown function (DUF881) COG3879 Cluster_661267 V1215813 YFMR S abc transporter COG0488 Cluster_599600 V1215816 S NA 11ZHA Cluster_582748 V1215819 S Relaxase mobilization nuclease 0Y9PG Cluster_585933 V1215822 ADH map00051,map00363,map00591,map00625,map00650,map01100,map01120 C alcohol dehydrogenase COG1454 Cluster_734667 V1215823 STSB P Binding-protein-dependent transport systems, inner membrane component COG0601 Cluster_585934 V1215826 METE map00270,map00450,map01100,map01110,map01230 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) COG0620 Cluster_585935 V1215830 SOJ D Chromosome Partitioning Protein COG1192 Cluster_589236 V1215834 P binding-protein-dependent transport systems inner membrane Component COG4986 Cluster_589237 V1215836 CAS3 L CRISPR-associated helicase, cas3 COG1203 Cluster_705339 V1215837 MIDI_00056 L Transposase 0YEAS Cluster_589238 V1215838 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_589239 V1215839 L Integrase, catalytic region COG2801 Cluster_592602 V1215842 MT1293 map00350,map00362,map00627,map00642,map00903,map01120 I Acyl-transferase COG1835 Cluster_592603 V1215843 NDVA2 V ABC transporter, ATP-binding protein COG1132 Cluster_592604 V1215847 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_592605 V1215848 THIO map00730 E glycine oxidase COG0665 Cluster_596087 V1215850 S NA 11SYG Cluster_721526 V1215855 S NA 0ZTGB Cluster_702258 V1215860 PURF map00230,map00250,map01100,map01110 F glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_855515 V1215861 VICX map03013 S domain protein COG1235 Cluster_610441 V1215875 V ATPase associated with various cellular activities aaa_5 COG1401 Cluster_606774 V1215876 NQRE C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG2209 Cluster_610442 V1215877 C domain protein COG0426 Cluster_606775 V1215878 L Resolvase COG1961 Cluster_610443 V1215884 L type iii restriction protein res subunit COG3886 Cluster_610444 V1215888 RARA L recombination factor protein RarA COG2256 Cluster_614086 V1215897 DAPB map00300,map01100,map01110,map01120,map01230 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) COG0289 Cluster_621524 V1215901 HELY L helicase COG4581 Cluster_758480 V1215902 DCIAE E Extracellular solute-binding protein, family 5 COG0747 Cluster_617857 V1215903 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_644778 V1215904 CPDB map00230,map00240,map00760,map01100,map01110 F 5-nucleotidase COG0737 Cluster_621525 V1215906 L site-specific recombinase, phage integrase family 0ZJK4 Cluster_621526 V1215910 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_625309 V1215917 TRAA L TrwC relaxase COG0507 Cluster_629035 V1215923 S Rib/alpha-like repeat 10008 Cluster_625310 V1215924 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_629036 V1215928 map00270,map00920,map01100,map01120,map01230 E serine acetyltransferase COG1045 Cluster_687551 V1215929 S NA 0YF67 Cluster_741423 V1215930 HISE2 E Hydrolase COG0637 Cluster_632855 V1215932 NRDF map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_632856 V1215933 YQEY S gatB Yqey COG1610 Cluster_632857 V1215934 NUOE map00190,map00910,map01100 C NADH dehydrogenase (Ubiquinone), 24 kDa subunit COG1905 Cluster_636884 V1215940 THIE map00730,map01100 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) COG0422 Cluster_665440 V1215947 S HipA domain protein COG3550 Cluster_711569 V1215950 MURE map00300,map00550 M mur ligase COG0769 Cluster_648826 V1215957 DINF V Mate efflux family protein COG0534 Cluster_762244 V1215959 PURC map00230,map01100,map01110 F SAICAR synthetase COG0152 Cluster_648827 V1215962 S phosphate 0XP49 Cluster_820693 V1215963 ATPH map00190,map00195,map01100 C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) COG0712 Cluster_648828 V1215965 TYRA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydrogenase COG0287 Cluster_766215 V1215971 NTPJ P Potassium uptake protein COG0168 Cluster_652920 V1215976 S (LipO)protein 0YDWI Cluster_652921 V1215977 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_789203 V1215980 PKNB T Serine Threonine protein kinase COG0515 Cluster_661268 V1215981 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_828513 V1215991 GSHA map00480,map01100 H glutamate--cysteine ligase COG3572 Cluster_702259 V1215995 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_665442 V1216000 MAEB map00620,map00710,map01100,map01120,map02020 C Malic enzyme COG0281 Cluster_669750 V1216003 GLGC map00500,map00520,map01100,map01110 G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) COG0448 Cluster_674140 V1216005 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_674141 V1216010 ILVB map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E Acetolactate synthase, large subunit COG0028 Cluster_678589 V1216015 F cytosine purines uracil thiamine allantoin COG1457 Cluster_678590 V1216018 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_678591 V1216019 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_683116 V1216020 SCLAV_3021 S (twin-arginine translocation) pathway signal COG3211 Cluster_683117 V1216023 S NA 11NI8 Cluster_683118 V1216025 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_687553 V1216029 LDH map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120 C L-Lactate dehydrogenase COG0039 Cluster_687554 V1216032 COBW S Cobalamin synthesis protein cobW C-terminal domain COG0523 Cluster_687555 V1216034 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_692082 V1216038 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_102249 V1216040 N, U spore coat assembly protein SafA COG1388 Cluster_26031 V1216041 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG2812 Cluster_115556 V1216042 P Chloride channel COG0038 Cluster_83005 V1216043 GATA map00970,map01100 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) COG0154 Cluster_300819 V1216044 YLME F alanine racemase domain protein COG0325 Cluster_187314 V1216045 GLUQ map00860,map00970,map01100,map01110 J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) COG0008 Cluster_110054 V1216046 MURE map00300,map00550 M mur ligase COG0769 Cluster_81748 V1216047 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_56498 V1216049 S integral membrane protein 0XS1S Cluster_250305 V1216051 RV1825 S Bacterial protein of unknown function (DUF881) COG3879 Cluster_179495 V1216052 GLUD map02010 E amino acid AbC transporter COG0765 Cluster_32077 V1216055 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_112762 V1216056 VEX3 V abc transporter permease protein COG0577 Cluster_116284 V1216058 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_62368 V1216059 GSIA map02010 S ABC transporter COG1123 Cluster_8113 V1216060 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_49794 V1216062 M Inherit from NOG: Lpxtg-motif cell wall anchor domain protein 0Y6CS Cluster_160372 V1216063 M Sortase family COG3764 Cluster_378821 V1216064 S NA 11QRM Cluster_21000 V1216065 S NA 11QZ9 Cluster_398271 V1216066 S NA 11WG4 Cluster_25115 V1216067 PARE L DNA topoisomerase IV subunit B COG0187 Cluster_21222 V1216069 T Histidine kinase COG4585 Cluster_6505 V1216070 RV3193C S UPF0182 protein COG1615 Cluster_27362 V1216071 METE map00270,map00450,map01100,map01110,map01230 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) COG0620 Cluster_8921 V1216072 GLNE O, T Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) COG1391 Cluster_355388 V1216073 PYRE map00240,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_484983 V1216074 HSDS V restriction -modification system COG0732 Cluster_21309 V1216075 S NA 0Y9Z0 Cluster_744735 V1216076 SP_0122 S UPF0356 protein COG5503 Cluster_185556 V1216077 S Auxin Efflux Carrier COG0679 Cluster_777342 V1216078 K Transcriptional regulator 0XUP9 Cluster_49367 V1216080 S atpase involved in dna repair 0XRFS Cluster_347312 V1216081 SURB S G5 domain protein 0ZVV3 Cluster_205040 V1216082 S ApbE family 11H27 Cluster_136682 V1216083 Y2367 P integral membrane protein COG4393 Cluster_389405 V1216084 S FMN_bind 12BR0 Cluster_189014 V1216085 NRDF map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_31504 V1216086 NRDE map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_617858 V1216087 S NA 126R7 Cluster_467193 V1216088 S GtrA-like protein 11U0Q Cluster_7444 V1216089 S NA 12BGB Cluster_398272 V1216090 AASI_0458 S WbqC-like 0ZW99 Cluster_193477 V1216091 S Protein of unknown function (DUF1189) 0Y1IJ Cluster_357078 V1216093 M Ompa motb domain protein COG2885 Cluster_24466 V1216094 IRP P tonB-dependent Receptor COG1629 Cluster_280359 V1216096 LICD3 M licD family COG3475 Cluster_265670 V1216097 SAGE S CAAX amino protease family protein 0XUJM Cluster_102250 V1216098 BVU_1425 L Transposase COG3039 Cluster_242523 V1216099 P ABC 3 transport family protein COG1108 Cluster_242524 V1216100 CPSY K Transcriptional regulator COG0583 Cluster_358752 V1216102 S NA 12BYI Cluster_30714 V1216103 S p-loop domain protein COG4928 Cluster_4558 V1216104 SP_1222 V restriction endonuclease 0ZVJ1 Cluster_218459 V1216105 S Type II DNA modification methyltransferase 0ZM02 Cluster_62369 V1216106 NADE map00760,map01100 H Nad synthetase COG0388 Cluster_182983 V1216108 TILS map00230,map00983,map01100,map01110 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) COG0037 Cluster_70888 V1216109 SSCG_00971 S integral membrane transport protein 0XP2U Cluster_124090 V1216110 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_46725 V1216111 RGPF M Rhamnan synthesis protein F COG3754 Cluster_25497 V1216112 MRCB map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_176948 V1216115 L Reverse transcriptase COG3344 Cluster_276389 V1216123 SCLAV_2148 S NA 0XNX0 Cluster_396546 V1216124 S NA 0ZG83 Cluster_557670 V1216130 S NA 0ZAU4 Cluster_269732 V1216131 S NA 11NRA Cluster_161202 V1216135 L Integrase COG0582 Cluster_203966 V1216137 DPPC map02010 P ABC transporter (Permease) COG1173 Cluster_72480 V1216138 DPPA map02010 E ABC transporter substrate-binding protein COG4166 Cluster_499764 V1216139 AROQ map00400,map01100,map01110,map01230 E Catalyzes a trans-dehydration via an enolate intermediate (By similarity) COG0757 Cluster_61270 V1216140 AROB map00400,map01100,map01110,map01230 E 3-dehydroquinate synthase COG0703 Cluster_12711 V1216141 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_47286 V1216142 TYPA T gtp-binding protein typa COG1217 Cluster_70889 V1216143 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_188172 V1216144 COMGB U Competence protein COG1459 Cluster_106411 V1216145 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_300820 V1216146 S NA 101UU Cluster_36263 V1216148 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_156099 V1216149 FRDB map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020 C succinate dehydrogenase COG0479 Cluster_302215 V1216150 RSME S Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) COG1385 Cluster_131890 V1216151 PHOH T Phoh family COG1702 Cluster_82539 V1216152 GLDE P CBS domain containing protein COG1253 Cluster_16668 V1216154 S domain protein 0XPXI Cluster_150444 V1216155 S Cell surface-anchored protein 1005T Cluster_335034 V1216157 YJBH Q Dithiol-disulfide isomerase COG2761 Cluster_809124 V1216158 FLUTA_0256 L Transposase COG3464 Cluster_375277 V1216159 YADS S Membrane COG2860 Cluster_34909 V1216160 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_95699 V1216161 L Domain protein COG0507 Cluster_347313 V1216162 ORN map03008 A 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) COG1949 Cluster_365289 V1216163 SUA5 J sua5 ycio yrdc ywlc family protein COG0009 Cluster_252736 V1216164 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_226 V1216165 S NA 101UU Cluster_394759 V1216166 RPLY map03010 J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) COG1825 Cluster_38832 V1216167 FADD15 map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG1022 Cluster_610446 V1216169 S interferon-induced transmembrane protein 121MN Cluster_54998 V1216171 M Cell wall anchor domain protein 11Q8J Cluster_4217 V1216173 UVRD2 map03420,map03430 L helicase COG0210 Cluster_60648 V1216174 M Sulfatase COG1368 Cluster_124744 V1216175 L Integrase 0YTFQ Cluster_228938 V1216176 L site-specific recombinase, phage integrase family 0ZF8H Cluster_67888 V1216178 S NA 0YRIH Cluster_33523 V1216185 S NA 11VT6 Cluster_408812 V1216187 GNTK map00030,map00400,map01100,map01110,map01120,map01230 G carbohydrate kinase, thermoresistant glucokinase family COG3265 Cluster_26258 V1216188 map00550,map01100 M glycosyl transferase, family 51 COG0744 Cluster_255205 V1216189 S NA 0ZW0D Cluster_85116 V1216190 ASPC map00250,map00290,map01100,map01110,map01210,map01230 E Aminotransferase COG0436 Cluster_288677 V1216191 NFRA map00051,map00190,map00363,map00591,map00625,map00633,map00650,map01100,map01120 C nitroreductase COG0778 Cluster_306552 V1216192 K transcriptional regulator 0YJ72 Cluster_492111 V1216194 S Phage virion morphogenesis family 1281C Cluster_20845 V1216195 S Protein of unknown function (DUF935) COG4383 Cluster_338111 V1216196 S NA 0YDAR Cluster_234888 V1216197 L DNA primase 11GUV Cluster_62626 V1216199 PGN_0950 V ABC transporter, ATP-binding protein COG1132 Cluster_60140 V1216200 LMRA V ABC transporter, ATP-binding protein COG1132 Cluster_319895 V1216201 PYRP F permease COG2233 Cluster_273705 V1216202 LYC M glycoside hydrolase, family 25 11T0J Cluster_231258 V1216204 K transcriptional regulator, lysr family COG0583 Cluster_169456 V1216205 S domain protein 0YF83 Cluster_421509 V1216207 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_355389 V1216208 K Transcriptional regulator 1240D Cluster_89057 V1216209 S NA 101UU Cluster_408813 V1216211 V restriction enzyme 17CDW@proNOG Cluster_122150 V1216212 BL03512 M phage tail tape measure protein COG5283 Cluster_51323 V1216213 M Transferase COG1216 Cluster_164488 V1216214 S NA 0Y5S2 Cluster_181154 V1216215 GLFT1 M Glycosyl transferase, family 2 COG1216 Cluster_137470 V1216216 map00730,map04122 E Cysteine desulfurase COG0520 Cluster_227756 V1216217 QOR C Quinone oxidoreductase COG0604 Cluster_259038 V1216219 S NA 11X74 Cluster_6263 V1216220 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_219619 V1216221 YHBW C Luciferase family COG2141 Cluster_279055 V1216222 C l-carnitine dehydratase bile acid-inducible protein F COG1804 Cluster_245147 V1216223 TYRA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydrogenase COG0287 Cluster_428983 V1216224 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_11500 V1216225 MMPL2 S Membrane COG2409 Cluster_45360 V1216226 M Cell wall anchor domain protein 11Q8J Cluster_6597 V1216228 S NA 11QZ9 Cluster_371945 V1216233 SLYD O peptidylprolyl cis-trans isomerase COG1047 Cluster_25209 V1216234 S NA 0YRUB Cluster_107048 V1216235 HOM map00260,map00270,map00300,map01100,map01110,map01120,map01230 E homoserine dehydrogenase COG0460 Cluster_200883 V1216236 THRB map00260,map01100,map01120,map01230 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) COG0083 Cluster_702260 V1216238 S kila-n, DNA-binding domain 0XPNQ Cluster_785205 V1216239 S NA 1AQGC@spiNOG Cluster_347314 V1216240 S domain protein 0XNZW Cluster_348931 V1216242 CAS5D L CRISPR-associated protein 0XQ9Q Cluster_20079 V1216243 CAS3 L CRISPR-Associated Helicase Cas3 COG1203 Cluster_319896 V1216244 S NA 100T6 Cluster_277694 V1216245 O DnaJ domain protein COG0484 Cluster_300821 V1216246 OPPF map02010 E (ABC) transporter COG4608 Cluster_370328 V1216248 S Tetratricopeptide repeat protein 0XZXZ Cluster_248 V1216250 FAS map00061,map01100 I fatty acid synthase COG4982 Cluster_21405 V1216251 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_230085 V1216252 YQJG O Glutathione S-transferase COG0435 Cluster_196957 V1216253 MSRA O reductase COG0229 Cluster_430956 V1216254 K HTH_XRE 0XUC3 Cluster_124091 V1216255 MGTE P magnesium transporter COG2239 Cluster_348932 V1216256 S Structural protein 11PKS Cluster_392953 V1216262 S structural protein 11RQ6 Cluster_2243 V1216265 S NA COG5412 Cluster_175329 V1216266 S NA 0YZKI Cluster_69935 V1216267 S NA 0YENI Cluster_310717 V1216272 S twiN-arginine translocation pathway 0XZIK Cluster_262960 V1216276 SSEA map00270,map01100,map04122 P sulfurtransferase COG2897 Cluster_226624 V1216277 S NA 0XSAP Cluster_440941 V1216278 S Phage-associated protein 11FS5 Cluster_174516 V1216279 S phage protein 0XQDU Cluster_329082 V1216280 S NA 11VCX Cluster_51920 V1216282 S Endonuclease 0XNXZ Cluster_231259 V1216283 S NgoFVII restriction endonuclease 127ZV Cluster_196958 V1216284 map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_52825 V1216287 S NA 128RV Cluster_178621 V1216289 L Type I restriction modification DNA specificity domain COG0732 Cluster_28668 V1216290 M Minor structural protein 0XPF3 Cluster_6362 V1216292 S Phage tail tape measure protein, TP901 family COG5283 Cluster_589241 V1216294 S Phage protein 12BKU Cluster_428984 V1216295 S Phage major tail protein 2 0XU4M Cluster_640919 V1216297 S Phage protein, HK97 gp10 family 0Y04J Cluster_261666 V1216300 S NA 11V19 Cluster_403559 V1216301 S NA 127XX Cluster_259039 V1216302 S NA 0YVYG Cluster_118397 V1216304 T phage Mu protein F like protein COG5585 Cluster_113500 V1216305 BL00983 S Phage Portal Protein 11QNG Cluster_137471 V1216306 BL00759 L Phage terminase, large subunit COG1783 Cluster_504696 V1216307 PS333 L terminase (Small subunit) COG3728 Cluster_560736 V1216309 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_582750 V1216318 CKL_1885 S Protein of unknown function (DUF1064) 1251H Cluster_480346 V1216320 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_15102 V1216322 XYLS map00052,map00500,map01100 G hydrolase, family 31 COG1501 Cluster_674 V1216323 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_123459 V1216324 TGT J Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COG0343 Cluster_144964 V1216325 MVK map00900,map01100,map01110,map04146 I mevalonate kinase COG1577 Cluster_693 V1216327 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_116285 V1216328 RV3630 S Membrane 11JY2 Cluster_217327 V1216329 SCLAV_3115 O DSBA oxidoreductase COG1651 Cluster_214995 V1216330 GALE map00052,map00520,map00521,map00523,map01055,map01100,map01110 M Polysaccharide biosynthesis protein COG0451 Cluster_119119 V1216331 G transporter 0XP7I Cluster_161203 V1216332 ACX map00071,map00592,map01040,map01100,map03320,map04146 I acyl-CoA oxidase COG1960 Cluster_227757 V1216333 S integral membrane protein 11J5I Cluster_114875 V1216334 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0470 Cluster_137472 V1216335 S Membrane COG2311 Cluster_75163 V1216336 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG1754 Cluster_152875 V1216338 L Site-specific recombinase, phage integrase family 11F8N Cluster_135062 V1216339 S Conserved Protein COG4804 Cluster_62082 V1216340 S Protein of unknown function (DUF1524) COG1479 Cluster_373562 V1216341 S NA 0Y3II Cluster_246474 V1216342 S Relaxase mobilization nuclease 11PW0 Cluster_212688 V1216343 S NA 0ZC4R Cluster_113501 V1216344 S NA 1211J Cluster_322947 V1216349 D Chromosome Partitioning Protein COG1192 Cluster_300823 V1216355 THYA map00240,map00670,map01100 F Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) COG0207 Cluster_199878 V1216360 MT0027 M NLP P60 family protein COG0791 Cluster_339547 V1216367 S SNARE associated Golgi protein 0YNB0 Cluster_191662 V1216371 ECORIM L Modification methylase EcoRI 0XPU0 Cluster_99482 V1216374 PBPA map00550 M penicillin-binding protein COG0768 Cluster_38990 V1216375 PKNB T Serine Threonine protein kinase COG2815 Cluster_366998 V1216376 TRPG map00230,map00400,map00790,map00983,map01100,map01110,map01230 E anthranilate synthase COG0512 Cluster_640920 V1216377 S Transmembrane domain of unknown function (DUF3566) 11X32 Cluster_45361 V1216380 PLCN map00562,map00564,map00565,map01100 M phospholipase C COG3511 Cluster_266981 V1216381 S Alpha Beta Hydrolase COG4757 Cluster_144213 V1216382 NLPD M peptidase M23 COG0739 Cluster_361984 V1216383 map00630,map01100,map01110 S had-superfamily hydrolase, subfamily ia, variant COG0546 Cluster_428985 V1216384 BIOY map02010 S bioY protein COG1268 Cluster_277695 V1216385 K Transcriptional regulator 11GAC Cluster_36868 V1216386 S Secreted protein 0XRGW Cluster_237287 V1216387 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_636886 V1216388 S toxin-antitoxin system, antitoxin component, ribbon-helix-helix 11U5W Cluster_41040 V1216389 S Uncharacterized conserved protein (DUF2075) 0XPB6 Cluster_287324 V1216390 UDP map00230 S phosphorylase 11F11 Cluster_261667 V1216391 map02010 E, T ABC transporter substrate-binding protein COG0834 Cluster_14636 V1216392 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_75788 V1216393 GGT map00430,map00460,map00480,map00590,map01100 E gamma-glutamyltransferase COG0405 Cluster_338112 V1216394 THIE map00730,map01100 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) COG0352 Cluster_8114 V1216395 S NA 0YB9V Cluster_21625 V1216396 MPRF map05150 J Membrane COG2898 Cluster_6131 V1216397 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0047 Cluster_128180 V1216398 P Transporter COG0471 Cluster_194415 V1216400 S NA 0YZ0Q Cluster_216126 V1216412 RHUM S DNA-binding protein COG3943 Cluster_554750 V1216413 S Domain of unknown function (DUF955) 0Z637 Cluster_268384 V1216417 DMNB map03430 L D12 class N6 adenine-specific DNA methyltransferase COG0338 Cluster_171143 V1216419 L Integrase COG0582 Cluster_440942 V1216421 map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase family protein COG0406 Cluster_366999 V1216423 S NA 1224P Cluster_90910 V1216424 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_143463 V1216425 S UPF0597 protein COG3681 Cluster_166879 V1216429 K acetyltransferase COG0454 Cluster_245148 V1216431 S NA 11W41 Cluster_148820 V1216432 RV0433 S ATP-dependent carboxylate-amine ligase (By similarity) COG2170 Cluster_617861 V1216433 MRPG P monovalent cation proton antiporter, MnhG PhaG subunit 1224K Cluster_377046 V1216434 MRPE P monovalent cation H antiporter subunit E COG1863 Cluster_64840 V1216435 MRPD P Monovalent cation H antiporter subunit D COG0651 Cluster_12419 V1216436 MRPA map00190 P monovalent cation H antiporter subunit A COG2111 Cluster_296772 V1216437 MNTB map02010 P (ABC) transporter COG1121 Cluster_85117 V1216438 ERIC P Chloride channel COG0038 Cluster_115557 V1216439 V Mate efflux family protein COG0534 Cluster_211605 V1216440 GCVT map00260,map00670,map00910,map01100 E The glycine cleavage system catalyzes the degradation of glycine (By similarity) COG0404 Cluster_22099 V1216441 V Efflux ABC transporter, permease protein 0XPE8 Cluster_268385 V1216442 T Histidine kinase COG0642 Cluster_4816 V1216443 V abc transporter permease protein COG0577 Cluster_382314 V1216444 S Conjugative transposon protein TraI 0YE08 Cluster_232422 V1216445 TRAN S Conjugative transposon TraN protein 0XNQ2 Cluster_412489 V1216446 TRAO S conjugative transposon protein TraO 0YB3M Cluster_509868 V1216447 TRAQ2 S conjugative transposon protein TraQ 11SF8 Cluster_344111 V1216449 S UbiE COQ5 family 11KJ9 Cluster_380547 V1216450 S NA 0Z1FC Cluster_12076 V1216451 L N-6 DNA Methylase 0XTBT Cluster_731448 V1216453 S NA 0YWQY Cluster_135875 V1216454 S NA 0XNWW Cluster_198886 V1216455 S Oxidoreductase family, C-terminal alpha/beta domain COG0673 Cluster_327587 V1216464 S NA 11YW7 Cluster_284479 V1216467 LYTA M n-acetylmuramoyl-l-alanine amidase 123CS Cluster_582752 V1216468 S toxin secretion phage lysis holin 0XUV6 Cluster_179496 V1216476 METE map00270,map00450,map01100,map01110,map01230 E Methionine synthase COG0620 Cluster_10295 V1216477 S NA 0YB9V Cluster_6038 V1216478 V type I restriction-modification system COG0732 Cluster_138985 V1216480 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_378822 V1216481 RHTC E Lysine exporter protein (Lyse ygga) COG1280 Cluster_141260 V1216482 S Secreted protein 11J24 Cluster_241153 V1216483 PHEA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydratase COG0077 Cluster_108793 V1216484 AMIDASE map00330,map00360,map00380,map00627,map00643,map01120 J Amidase (EC 3.5.1.4) COG0154 Cluster_277696 V1216485 YNIA map00564,map01100 G Fructosamine kinase COG3001 Cluster_253995 V1216486 LYTR2 K TRANSCRIPTIONal COG1316 Cluster_249042 V1216487 SCLAV_2829 S Sec-C motif domain protein 100MK Cluster_44834 V1216489 PYKF4 map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG0469 Cluster_62370 V1216490 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_95700 V1216492 S Calcineurin-like phosphoesterase 0YC4X Cluster_152043 V1216493 FADE23 map00071,map00280,map00410,map00640,map01100,map01110,map03320 I acyl-Coa dehydrogenase 0XP8P Cluster_105186 V1216494 FADE24 map00281,map01110 I acyl-Coa dehydrogenase 0XT9E Cluster_80160 V1216495 SPEE map00270,map00330,map00410,map00480,map01100 E Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) COG4262 Cluster_471478 V1216496 RV2600 S Membrane 11XBK Cluster_463024 V1216499 GLGB map00500,map01100,map01110 G pullulanase, type i COG1523 Cluster_210468 V1216500 S NA 125P7 Cluster_233690 V1216502 S NurA domain protein 11IQE Cluster_54532 V1216503 S Domain of unknown function DUF87 COG0433 Cluster_6955 V1216504 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_6318 V1216505 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_285917 V1216506 ECFA1 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_273706 V1216507 ECFA2 map02010 P Abc transporter COG1122 Cluster_302216 V1216508 ECFT map02010 P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) COG0619 Cluster_333533 V1216509 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_380548 V1216510 RPLD map03010 J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) COG0088 Cluster_157812 V1216511 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_35428 V1216512 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_592607 V1216513 RPSL map03010 J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) COG0048 Cluster_380549 V1216514 map00240,map00330,map01100 G, M epimerase dehydratase COG0702 Cluster_9092 V1216515 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_266982 V1216516 L Recombinase COG1961 Cluster_281701 V1216519 M N-Acetylmuramoyl-L-alanine amidase COG3023 Cluster_497102 V1216520 S toxin secretion phage lysis holin COG4824 Cluster_13041 V1216522 M Phage minor structural protein COG4926 Cluster_465108 V1216523 S tail component COG4722 Cluster_16937 V1216524 CRES_0873 S Tape measure protein 0YD0X Cluster_551889 V1216526 CRES_0875 S NA 11SKH Cluster_482656 V1216528 YTSP T gaf domain protein COG1956 Cluster_184675 V1216529 S NA 0YXMU Cluster_23491 V1216530 M Ser Thr phosphatase family protein COG2247 Cluster_147280 V1216531 L site-specific recombinase, phage integrase family 0ZF8H Cluster_172873 V1216532 S NA 17MYW@proNOG Cluster_200884 V1216533 S NA 0XT2A Cluster_335035 V1216534 S NA 11MJM Cluster_225501 V1216535 S Nucleotidyl transferase of unknown function (DUF1814) 0XP6B Cluster_363553 V1216536 C PBS lyase HEAT domain protein repeat-containing protein COG1413 Cluster_789205 V1216537 S NA 11QA3 Cluster_621528 V1216538 S protein, conserved in bacteria COG1937 Cluster_31967 V1216539 ACTP P p-type atpase COG2217 Cluster_832234 V1216540 COPZ map04978 P heavy metal transport detoxification protein 0XUQ1 Cluster_161204 V1216541 V HNHc 125G9 Cluster_85911 V1216542 AMN map00230 F Amp nucleosidase COG0775 Cluster_137473 V1216543 MNTH P H( )-stimulated, divalent metal cation uptake system (By similarity) COG1914 Cluster_512447 V1216544 S multimeric flavodoxin wrba COG0655 Cluster_223150 V1216545 GLUQ map00860,map00970,map01100,map01110 J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) COG0008 Cluster_230086 V1216546 map02010 P ABC transporter COG1131 Cluster_196959 V1216548 UBIA H Prenyltransferase COG0382 Cluster_414354 V1216549 I Membrane-associated phospholipid phosphatase COG0671 Cluster_39147 V1216550 GLFT M Transferase COG1216 Cluster_245149 V1216551 CMTB S esterase COG0627 Cluster_243876 V1216552 S EamA-like transporter family 129W1 Cluster_93293 V1216553 CSP M n-acetylmuramoyl-l-alanine amidase COG5479 Cluster_25210 V1216554 CSP M n-acetylmuramoyl-l-alanine amidase COG5479 Cluster_336568 V1216555 MT3922 S hydrolase COG0561 Cluster_93294 V1216556 PLSC map00561,map00564,map01100 I Acyl-transferase 0Z3QU Cluster_14637 V1216557 HSDR V Type I Restriction COG0610 Cluster_31739 V1216558 FADB map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00640,map00650,map00720,map00903,map00930,map01040,map01100,map01110,map01120 I 3-hydroxyacyl-CoA dehydrogenase COG1250 Cluster_74182 V1216559 YDIU S UPF0061 protein COG0397 Cluster_60959 V1216560 DPPA map02010 E ABC transporter substrate-binding protein COG4166 Cluster_245150 V1216561 DPPB map02010 P ABC transporter (Permease) COG0601 Cluster_211606 V1216562 DPPC map02010 P ABC transporter (Permease) COG1173 Cluster_281702 V1216563 CITE map00020,map01110,map02020 G Citrate lyase COG2301 Cluster_37324 V1216564 map00061,map00280,map00630,map00640,map00720,map01100,map01120 I carbamoyL-phosphate synthase l chain ATP-binding COG4770 Cluster_78111 V1216565 MCCB map00280,map00720,map01100,map01120 I carboxylase COG4799 Cluster_53273 V1216566 S Membrane 11NP1 Cluster_480347 V1216567 S Thioesterase 11UBJ Cluster_338113 V1216568 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_110739 V1216569 MNME S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 Cluster_184676 V1216570 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_126797 V1216573 S NA 0XPEA Cluster_128181 V1216574 GSHA map00480,map01100 H glutamate--cysteine ligase COG3572 Cluster_306553 V1216575 S Metal dependent hydrolase COG2220 Cluster_17142 V1216576 ATP2C1 P p-type ATPase COG0474 Cluster_19204 V1216577 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_499766 V1216580 OGT L Methyltransferase COG0350 Cluster_59586 V1216581 S Membrane 0ZI5H Cluster_209396 V1216582 LTAE map00260,map01100,map01110,map01120,map01230 E Aldolase COG2008 Cluster_69936 V1216583 map02010 E ABC, transporter COG4166 Cluster_249043 V1216584 OPPC map02010 P abc transporter, permease COG1173 Cluster_382315 V1216585 NT5E map00230,map00240,map00630,map00760,map01100,map01110 S Hydrolase COG0546 Cluster_279056 V1216586 AADK S Aminoglycoside 6-adenylyltransferase 0YSKJ Cluster_781083 V1216587 ENTF map00250,map01053,map01054 Q non-ribosomal peptide synthetase COG1020 Cluster_392954 V1216588 S integral membrane protein 11P1U Cluster_327588 V1216589 map02010 P Cobalt transport protein COG0619 Cluster_92359 V1216590 SLGD_00064 map02010 P ABC transporter COG1122 Cluster_62900 V1216591 map02010 V ABC transporter COG1132 Cluster_59072 V1216592 V abc transporter COG1132 Cluster_307861 V1216593 IRP4 Q Thioesterase COG3208 Cluster_161205 V1216594 M glycosyl transferase family COG1819 Cluster_391139 V1216595 MAA map00350,map00362,map00627,map00642,map00903,map01120 E O-Acetyltransferase COG0110 Cluster_193478 V1216596 map02010 P ABC transporter 0XXUP Cluster_319897 V1216597 DRRB map02010 V ABC, transporter COG0842 Cluster_434885 V1216599 TPAU_0274 L transposase COG3547 Cluster_104592 V1216601 S NA 0Z34Z Cluster_37800 V1216602 L Dna topoisomerase COG0550 Cluster_119889 V1216603 NNRD G Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) COG0063 Cluster_108180 V1216604 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_113503 V1216605 TRKA P potassium transporter peripheral membrane COG0569 Cluster_96287 V1216606 TRKH P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) COG0168 Cluster_106412 V1216607 TRKA P potassium transporter peripheral membrane COG0569 Cluster_336569 V1216608 SUPH S Hydrolase COG0561 Cluster_423367 V1216609 AARI_34720 L Transposase COG3547 Cluster_469332 V1216610 AARI_34720 L Transposase COG3547 Cluster_471479 V1216612 S Transporter Permease Protein 0Z4FB Cluster_30581 V1216613 YKOD map02010 P ABC transporter COG1122 Cluster_330482 V1216614 FADD32 I, Q amp-dependent synthetase and ligase COG1020 Cluster_324523 V1216616 DRRB map02010 V ABC, transporter COG0842 Cluster_63460 V1216618 IRTA map02010 V abc transporter COG1132 Cluster_401781 V1216619 CHER Q Methyltransferase COG0500 Cluster_257714 V1216620 map00051,map00500,map00520,map01100 G pfkb domain protein COG0524 Cluster_465109 V1216621 SCRA map00500,map02060 G PTS system COG2190 Cluster_288679 V1216622 FNT P nitrite transporter COG2116 Cluster_163680 V1216623 P drug resistance transporter, Bcr CflA 0XNNX Cluster_51524 V1216625 BIOF map00260,map00780,map01100 H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) COG1424 Cluster_442956 V1216626 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_55243 V1216627 MT1099 S Membrane COG4425 Cluster_410672 V1216628 SODA map04146,map05016 P Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) COG0605 Cluster_54533 V1216629 S recb family COG2251 Cluster_59882 V1216630 PHOD map00627,map00790,map01100,map01120,map02020 P Alkaline phosphatase COG3540 Cluster_115558 V1216631 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins COG0706 Cluster_396547 V1216632 MCBR K Transcriptional regulator 11WG2 Cluster_695900 V1216633 S Transglycosylase associated protein 0Z2KY Cluster_6242 V1216634 YLBB V abc transporter permease protein COG0577 Cluster_367000 V1216635 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_59346 V1216636 PGM map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_378823 V1216637 DEOC map00030 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) COG0274 Cluster_132637 V1216638 DEOA map00240,map00983,map01100,map05219 F The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) COG0213 Cluster_542984 V1216639 CDD map00240,map00983,map01100,map05219 F cytidine deaminase COG0295 Cluster_209397 V1216640 YJHU map00561,map00680,map01100,map01120,map04622 K Transcriptional regulator COG2390 Cluster_45362 V1216641 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_234890 V1216642 M lysozyme COG3757 Cluster_243877 V1216643 L decarboxylase COG1611 Cluster_423368 V1216644 MAF D MAF-like protein COG0424 Cluster_72157 V1216648 PPAC map00190 C Manganese-dependent inorganic pyrophosphatase COG1227 Cluster_741425 V1216649 RPSR map03010 J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) COG0238 Cluster_74812 V1216650 GLT map00630,map00910 E Glutamate synthase COG0069 Cluster_442957 V1216651 PURE map00230,map01100,map01110 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) COG0041 Cluster_71513 V1216652 PCCB map00280,map00630,map00640,map00720,map01100,map01120 I carboxyl transferase COG4799 Cluster_72819 V1216653 PCCB map00280,map00630,map00640,map00720,map01100,map01120 I propionyl-CoA carboxylase COG4799 Cluster_46524 V1216655 V restriction COG1401 Cluster_606778 V1216656 DIND S DNA-damage-inducible protein d 176AU@proNOG Cluster_350551 V1216657 RDGB map00230,map00240,map01100 F Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) COG0127 Cluster_271045 V1216658 MURI map00230,map00240,map00471,map01100 M Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) COG0796 Cluster_182080 V1216659 DMPA E, Q peptidase s58 dmpa COG3191 Cluster_438969 V1216660 S Domain of unknown function (DUF2017) 0XSEV Cluster_125406 V1216661 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_217328 V1216662 G Major Facilitator superfamily 0Z6XG Cluster_477933 V1216664 S NA 0YGJM Cluster_64018 V1216667 P sulfate transporter COG0659 Cluster_300824 V1216668 C Monooxygenase COG2141 Cluster_606779 V1216669 CMTR K arsR family transcriptional regulator COG0640 Cluster_49368 V1216670 CADA P heavy metal translocating p-type ATPase COG2217 Cluster_851745 V1216671 S NA 0Z8JS Cluster_335036 V1216672 S Pfam:DUF1089 12580 Cluster_520366 V1216673 YAEJ J class I peptide chain release factor COG1186 Cluster_731450 V1216674 S plasmid maintenance system antidote protein, xre family COG3093 Cluster_708446 V1216675 S Plasmid maintenance system killer COG3549 Cluster_967 V1216676 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_276390 V1216677 MREC M Involved in formation and maintenance of cell shape (By similarity) COG1792 Cluster_367001 V1216678 RADC L DNA repair protein (RadC COG2003 Cluster_220805 V1216679 SP_0859 S Membrane COG3817 Cluster_365290 V1216680 ENC_10390 S Membrane COG3819 Cluster_425155 V1216681 RNFG C Electron transport complex, RnfABCDGE type, G subunit COG4659 Cluster_122827 V1216682 RNFC C Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) COG4656 Cluster_384098 V1216683 M lytic transglycosylase COG0741 Cluster_95701 V1216684 FADD4 map00071,map01100,map03320,map04146,map04920 Q Amp-dependent synthetase and ligase COG0318 Cluster_245151 V1216685 THRB map00260,map01100,map01120,map01230 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) COG0083 Cluster_121388 V1216686 HOM map00260,map00270,map00300,map01100,map01110,map01120,map01230 E homoserine dehydrogenase COG0460 Cluster_102795 V1216687 LYSA map00300,map01100,map01110,map01120,map01230 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) COG0019 Cluster_70234 V1216688 ARGS map00970 J arginyL-tRNA synthetase COG0018 Cluster_375278 V1216689 YVFV map00630,map01100,map01110,map01120 C glycolate oxidase (iron-sulfur subunit) COG0247 Cluster_82120 V1216690 BMUL_5818 C Iron-sulfur cluster binding protein COG1139 Cluster_342521 V1216691 S Conserved Protein COG1556 Cluster_207229 V1216692 O pirin domain protein COG1741 Cluster_665443 V1216693 FECE map02010 P ABC transporter, ATP-binding protein COG1120 Cluster_182081 V1216694 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_796948 V1216695 YAAA S s4 domain protein COG2501 Cluster_192592 V1216696 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_47695 V1216697 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_640923 V1216698 RSBV T stage II sporulation protein COG1366 Cluster_401782 V1216700 V ABC, transporter COG1136 Cluster_112763 V1216701 FUMC map00020,map00720,map01100,map01110,map01120,map05200,map05211 C fumarate hydratase class II COG0114 Cluster_134262 V1216703 map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) COG1156 Cluster_62627 V1216704 CYDD map02010 V ABC, transporter COG4988 Cluster_333534 V1216705 YAAA L UPF0246 protein COG3022 Cluster_280360 V1216706 map02020 K Transcriptional regulator, ARAC family 11AZ4 Cluster_140507 V1216707 PYRP F permease COG2233 Cluster_554751 V1216708 map02020 V ABC transporter, permease COG0577 Cluster_38313 V1216709 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_416138 V1216710 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_145712 V1216711 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_27581 V1216712 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_438970 V1216713 YFCE S Phosphodiesterase COG0622 Cluster_47867 V1216714 UUP S Abc transporter COG0488 Cluster_285918 V1216715 VICX map03013 S domain protein COG1235 Cluster_288680 V1216716 TTCA D Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) COG0037 Cluster_156947 V1216717 FPRA C domain protein COG0426 Cluster_69605 V1216718 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_118398 V1216719 GCVPA map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG0403 Cluster_96288 V1216720 GCVPB map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG1003 Cluster_104593 V1216721 LPDA map00010,map00020,map00260,map00280,map00620,map01100,map01110,map01120 C dihydrolipoyl dehydrogenase COG1249 Cluster_154450 V1216722 HTRA map03010 M peptidase S1 and S6, chymotrypsin Hap COG0265 Cluster_117711 V1216723 YJIN S Membrane COG2733 Cluster_138986 V1216724 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_53274 V1216725 FADD map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG0318 Cluster_119120 V1216726 MSHA M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) COG0438 Cluster_8901 V1216727 FADF C Fe-S oxidoreductase COG0247 Cluster_368613 V1216728 T response regulator COG2197 Cluster_365291 V1216729 S NA 0YBW6 Cluster_412490 V1216730 S NA 0YHQV Cluster_176125 V1216731 C Luciferase-like COG2141 Cluster_417938 V1216732 ASPC map00250,map00290,map01100,map01110,map01210,map01230 E Aminotransferase COG0436 Cluster_212689 V1216733 S oxidoreductase 11GP7 Cluster_473593 V1216734 S Protein of unknown function (DUF1469) 102XY Cluster_224322 V1216735 EPHE S Alpha Beta Hydrolase Fold protein 0XRPK Cluster_275057 V1216736 SCLAV_2562 L nudix hydrolase COG0494 Cluster_319898 V1216737 MT3774 O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG0526 Cluster_309279 V1216738 NTH map03410 L endonuclease III COG0177 Cluster_492112 V1216740 SCLAV_2568 J endoribonuclease L-psp COG0251 Cluster_217329 V1216742 SCLAV_5135 S NA 0YWD2 Cluster_777343 V1216744 S NA 0YXSW Cluster_247736 V1216745 S NA 0YS7C Cluster_617862 V1216746 E Branched-chain amino acid 12BFW Cluster_275058 V1216747 CG3417 L nudix hydrolase COG0494 Cluster_27180 V1216748 MT4028 S NA 0XRB8 Cluster_281703 V1216749 CMTB S esterase COG0627 Cluster_42774 V1216750 CMTC M Trehalose corynomycolyl transferase COG5479 Cluster_246475 V1216752 ELRF S cutinase 11FQ6 Cluster_507281 V1216753 S TM2 domain COG2314 Cluster_85118 V1216754 DTPT E Transporter COG3104 Cluster_625312 V1216755 TRMB C Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_79788 V1216756 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_22700 V1216758 V FtsX-like permease family 0ZW5X Cluster_361985 V1216759 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_380550 V1216760 T response regulator COG0745 Cluster_88568 V1216761 GPMI map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0696 Cluster_189015 V1216762 COBD map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01230 E decarboxylase COG0079 Cluster_183799 V1216763 LTAE map00260,map01100,map01110,map01120,map01230 E Aldolase COG2008 Cluster_199879 V1216764 S filamentation induced by cAMP protein Fic COG3177 Cluster_15570 V1216765 ACTP P Copper-exporting ATPase COG2217 Cluster_438971 V1216766 CYSE map00270,map00920,map01100,map01120,map01230 E serine acetyltransferase COG1045 Cluster_287325 V1216767 NFO map03410 L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) COG0648 Cluster_276391 V1216768 NADE map00760,map01100 H nh(3)-dependent nad( ) synthetase COG0171 Cluster_454950 V1216769 K Tetr family transcriptional regulator COG1309 Cluster_335037 V1216770 O Secreted protein COG1651 Cluster_523145 V1216771 S doxx family 11VM9 Cluster_188173 V1216772 YLBL T Secreted protein COG3480 Cluster_92360 V1216773 SCLAV_4061 S Uncharacterised conserved protein (DUF2342) COG5282 Cluster_534403 V1216774 S metal-dependent hydrolase COG1451 Cluster_5453 V1216775 M NA 0ZP9N Cluster_1366 V1216776 APRE O Peptidase S8 and S53 subtilisin kexin sedolisin COG4412 Cluster_291288 V1216777 ESSC D ftsk spoIIIe COG1674 Cluster_88569 V1216778 S Protein of unknown function (DUF690) 11F8D Cluster_751504 V1216782 NRDH O (Glutaredoxin-like protein) NrdH COG0695 Cluster_120618 V1216787 NOX map00190 P pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_45363 V1216788 FBP map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120 G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 COG3855 Cluster_454951 V1216789 LEPB map03060 U Signal peptidase i COG0681 Cluster_132638 V1216790 S -dicarboxylate symporter COG1823 Cluster_504698 V1216791 map00633,map00680,map00720,map01120 C domain protein COG2080 Cluster_313738 V1216792 YGFM map00450 C FAD binding domain in molybdopterin dehydrogenase 0YU1D Cluster_149586 V1216793 M glycosyl transferase group 1 0ZWDI Cluster_143464 V1216794 ALBF P drug resistance transporter, EmrB QacA subfamily 0XNN3 Cluster_355390 V1216795 S aaa ATPase COG3910 Cluster_648831 V1216796 S Resuscitation-promoting factor 11WB2 Cluster_249044 V1216798 map00680,map00982,map01120 P oxidoreductase COG2072 Cluster_201878 V1216799 YGHZ map00051,map00363,map00591,map00625,map00650,map01100,map01120 C Aldo keto reductase COG0667 Cluster_275059 V1216800 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_44659 V1216801 E peptidase s9, prolyl oligopeptidase COG1506 Cluster_9155 V1216802 DNAE2 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase (By similarity) COG0587 Cluster_350552 V1216803 METI map02010 P ABC transporter, permease COG2011 Cluster_152876 V1216806 ILVA map00260,map00290,map01100,map01110,map01230 E threonine COG1171 Cluster_252737 V1216807 CITG map02020 H triphosphoribosyl-dephospho-CoA synthase COG1767 Cluster_4665 V1216808 O cysteine protease COG4870 Cluster_333535 V1216809 map00680 C Na H antiporter COG1757 Cluster_35994 V1216811 M efflux transporter, rnd family, mfp subunit COG0845 Cluster_141261 V1216812 V ABC transporter, permease COG0577 Cluster_209398 V1216813 MENC map00130,map01100,map01110 H O-succinylbenzoate synthase COG4948 Cluster_469333 V1216814 FECE map02010 P ABC transporter COG1120 Cluster_170319 V1216815 map02010 P ABC transporter permease COG0609 Cluster_176949 V1216816 YIUA map02010 P Periplasmic binding protein COG0614 Cluster_106413 V1216817 NORM V Mate efflux family protein COG0534 Cluster_252738 V1216818 TSB map00260,map00270,map01100,map01230 E Cysteine synthase COG0031 Cluster_89971 V1216819 SSCG_02586 map00300,map01100,map01110,map01120,map01230 E decarboxylase COG0019 Cluster_197891 V1216820 map00330,map01110,map01230 E Ornithine cyclodeaminase 10EHU Cluster_242525 V1216821 YDED E, G Membrane COG0697 Cluster_407058 V1216822 S CAAX amino terminal protease family 11SPS Cluster_125407 V1216823 YIEG S Xanthine uracil vitamin C permease COG2252 Cluster_5127 V1216824 S Inherit from NOG: LPXTG-motif cell wall anchor domain protein 0YEBJ Cluster_758483 V1216825 S sigma-70, region 4 11JJM Cluster_116994 V1216826 V MatE COG0534 Cluster_231260 V1216827 S NA 121AE Cluster_499767 V1216829 TRML map04122 J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) COG0219 Cluster_76095 V1216830 P Na Pi-cotransporter COG1283 Cluster_214996 V1216831 GAP map00010,map01100,map01110,map01120,map01230,map04066,map05010 G glyceraldehyde-3-phosphate dehydrogenase COG0057 Cluster_158689 V1216832 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_315325 V1216833 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_81749 V1216834 GPMI map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0696 Cluster_132639 V1216835 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_105804 V1216837 S Membrane COG4129 Cluster_355391 V1216838 SCLAV_3949 S Domain of unknown function (DUF1707) 11SS5 Cluster_300825 V1216839 S NA 11R2V Cluster_131891 V1216840 PURA map00230,map00250,map01100 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis COG0104 Cluster_147282 V1216842 GLPQ map00564 C glycerophosphoryl diester phosphodiesterase COG0584 Cluster_203967 V1216843 IUNH map00230,map00240,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_482658 V1216844 L NUDIX hydrolase COG0494 Cluster_220806 V1216845 NUSA K Transcription elongation factor NusA COG0195 Cluster_194416 V1216847 NRNA J phosphoesterase RecJ domain protein COG0618 Cluster_141262 V1216848 DINF V Mate efflux family protein COG0534 Cluster_231261 V1216849 LYTR K TRANSCRIPTIONal COG1316 Cluster_211607 V1216850 FNI map00900,map01100,map01110 C Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) COG1304 Cluster_450976 V1216851 BIOY map02010 S bioY protein COG1268 Cluster_357079 V1216852 S TIM-barrel fold 11FGY Cluster_194417 V1216853 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E amino acid aminotransferase COG0115 Cluster_53275 V1216854 CAPD map00051,map00362,map00363,map00521,map00523,map00591,map00625,map00626,map00650,map00903,map01055,map01100,map01110,map01120 M Polysaccharide biosynthesis protein COG1086 Cluster_226625 V1216855 map00260,map00680,map01100,map01120,map01230 E, H D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain COG0111 Cluster_361986 V1216856 K Transcriptional regulator, GntR family COG1802 Cluster_64019 V1216857 LMRA map02010 V abc transporter COG1132 Cluster_60960 V1216858 YFIC map02010 V ABC transporter COG1132 Cluster_162882 V1216859 BDHA map00051,map00363,map00591,map00625,map00650,map01100,map01120 C alcohol dehydrogenase COG1979 Cluster_318419 V1216860 SSUC map02010 P Binding-protein-dependent transport systems, inner membrane component COG0600 Cluster_345740 V1216861 S NA 0ZMT1 Cluster_162035 V1216865 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_332046 V1216867 SCLAV_0494 S integral membrane protein 11SWN Cluster_45568 V1216869 L Domain protein COG0507 Cluster_100557 V1216870 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0847 Cluster_711573 V1216873 O ADP-ribosylglycohydrolase COG1397 Cluster_875903 V1216874 O ADP-ribosylglycohydrolase COG1397 Cluster_161206 V1216875 NATB C, P ABC transporter, permease COG1668 Cluster_188174 V1216876 S Membrane COG4194 Cluster_585936 V1216877 K Transcriptional regulator, GntR family COG1725 Cluster_116286 V1216878 map00190,map00680,map01100 C ATP synthase alpha/beta chain, C terminal domain COG1155 Cluster_269733 V1216879 SCLAV_2396 H NADP oxidoreductase, coenzyme f420-dependent COG5495 Cluster_136683 V1216880 S NA 11QQB Cluster_212690 V1216881 FOLP map00790,map01100 H dihydropteroate synthase COG0294 Cluster_423369 V1216882 FOLE map00790,map01100 H GTP cyclohydrolase i COG0302 Cluster_17370 V1216883 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_758484 V1216884 S Inherit from COG: Alpha beta hydrolase COG0596 Cluster_828515 V1216885 S reductase COG1028 Cluster_152877 V1216886 S copper amine 121X1 Cluster_265672 V1216887 S NA 0YIZN Cluster_542985 V1216888 S NA 0YRPX Cluster_247737 V1216891 PYRB map00240,map00250,map01100 F aspartate transcarbamylase COG0540 Cluster_534404 V1216892 PYRI map00240,map00250,map01100 F Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) COG1781 Cluster_156100 V1216893 PYRC map00230,map00240,map00410,map00770,map00983,map01100,map01120 F dihydroorotase COG0044 Cluster_277697 V1216894 PYRF map00240,map00983,map01100 F orotidine 5''-phosphate decarboxylase COG0284 Cluster_342522 V1216895 PYRK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) COG0543 Cluster_257715 V1216896 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate (By similarity) COG0167 Cluster_425156 V1216897 PYRE map00240,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_348933 V1216898 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_310718 V1216899 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_193479 V1216900 ISPG map00900,map01100,map01110 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) COG0821 Cluster_216127 V1216901 NTPC map00190,map00680,map01100 C ATP synthase subunit C COG1527 Cluster_436934 V1216902 ATPE map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG1390 Cluster_46141 V1216903 NTPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_365292 V1216904 UPP map00240,map01100 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) COG0035 Cluster_205042 V1216905 SUA J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0009 Cluster_214997 V1216906 YBHK S UPF0052 protein COG0391 Cluster_275060 V1216907 YHBJ S Displays ATPase and GTPase activities (By similarity) COG1660 Cluster_326022 V1216908 HIS2 L PHP domain protein COG1387 Cluster_442958 V1216909 RPLE map03010 J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COG0094 Cluster_440943 V1216910 OGT L Methyltransferase COG0350 Cluster_198887 V1216912 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_256432 V1216913 I May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) COG1597 Cluster_142766 V1216914 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_403561 V1216915 UDK map00240,map00710,map00983,map01100,map01120 F uridine monophosphokinase COG0572 Cluster_37325 V1216916 TEX K domain protein COG2183 Cluster_62628 V1216917 PEPTIDASE E prolyl oligopeptidase COG1505 Cluster_99483 V1216918 RAMB K transcriptional regulator COG3800 Cluster_292647 V1216919 S abc transporter atp-binding protein 0XQ1Z Cluster_132640 V1216920 MLEP map02020 C citrate carrier protein COG3493 Cluster_162883 V1216921 MDH map00620,map00710,map01100,map01120,map02020 C malate dehydrogenase (Oxaloacetate-decarboxylating) COG0281 Cluster_152044 V1216922 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_95203 V1216923 YCAM E amino acid COG0531 Cluster_94686 V1216924 NRDF map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_212691 V1216925 BIOB map00780,map01100 H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) COG0502 Cluster_189880 V1216926 NADA map00760,map01100 H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) COG0379 Cluster_96807 V1216927 NADB map00250,map00760,map01100 H L-aspartate oxidase COG0029 Cluster_277698 V1216931 VDLC S short-chain dehydrogenase reductase COG1028 Cluster_150445 V1216932 SCLAV_5207 map00300,map00310,map01100,map01110,map01230 S Saccharopine dehydrogenase COG3268 Cluster_152878 V1216933 YNFM G Major Facilitator Superfamily 0XP8J Cluster_151214 V1216934 S Filamentation induced by cAMP protein fic COG3177 Cluster_335038 V1216935 YLME F alanine racemase domain protein COG0325 Cluster_557674 V1216936 GUAB3 map00230,map00983,map01100,map01110 F Dehydrogenase COG0516 Cluster_60649 V1216937 CHOD map00984 E Cholesterol oxidase COG2303 Cluster_78785 V1216938 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_669752 V1216940 S Antibiotic biosynthesis monooxygenase COG2329 Cluster_347316 V1216941 RV3395C S DNA repair 129Q4 Cluster_68894 V1216942 MT3501 L polymerase involved in DNA repair COG0389 Cluster_502298 V1216943 S Secreted protein 11Z2N Cluster_333536 V1216944 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_398273 V1216945 MAG map03410 L 3-methyladenine DNA glycosylase COG2094 Cluster_389406 V1216946 PYRE map00240,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_21766 V1216947 SURB S G5 domain protein 0ZVV3 Cluster_175330 V1216948 APBE H ApbE family COG1477 Cluster_291289 V1216949 PS305 S Protein of unknown function (Hypoth_ymh) 10DNB Cluster_44835 V1216950 POLA_2 L DNA polymerase 0XRUF Cluster_436935 V1216952 S Phage-associated protein 11FS5 Cluster_173709 V1216953 S phage protein 0XQDU Cluster_540108 V1216954 S rRNA biogenesis protein Rrp5 0XUK3 Cluster_417939 V1216956 S NA 0Z4HT Cluster_144965 V1216957 S NA 11HCX Cluster_762245 V1216958 S NA 0XZ2W Cluster_52591 V1216959 ASNB map00250,map00910,map01100,map01110,map01120 E asparagine synthetase COG0367 Cluster_162036 V1216960 COXB map00190,map00910,map01100 C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) COG1622 Cluster_62629 V1216961 EXPZ S ABC transporter COG0488 Cluster_72820 V1216962 C Inherit from COG: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) COG1290 Cluster_224323 V1216963 QCRA map00190,map00910,map01100,map02020,map04260,map05010,map05012,map05016 C c reductase, iron-sulfur COG0723 Cluster_124092 V1216964 HOXA map02020 T Sigma-54 interaction domain protein COG2204 Cluster_27967 V1216965 T ATPase histidine kinase DNA gyrase B HSP90 domain protein 0XNMH Cluster_484984 V1216968 S HD domain protein COG1418 Cluster_62083 V1216969 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG0469 Cluster_231262 V1216970 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G phosphohexokinase COG0205 Cluster_458857 V1216971 COAA map00770,map01100 H pantothenic acid kinase COG1072 Cluster_150446 V1216972 V Hnh endonuclease 11M4H Cluster_440944 V1216973 SAT2 map00350,map00362,map00627,map00642,map00903,map01120 K gCN5-related N-acetyltransferase COG0454 Cluster_321381 V1216974 PAAB map00360,map01120 Q Enoyl-CoA hydratase COG1024 Cluster_79478 V1216975 METP P -transporter COG0733 Cluster_119121 V1216976 S nucleoside recognition domain protein COG3314 Cluster_187315 V1216977 ARSB P arsenicaL-resistance protein COG0798 Cluster_208349 V1216978 S Copper amine oxidase N-terminal domain 0YD2Q Cluster_494597 V1216979 MGSA map00620 G methylglyoxal synthase COG1803 Cluster_155291 V1216980 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_154451 V1216981 FABG map00061,map00780,map01040,map01100 I reductase COG1028 Cluster_3267 V1216983 S Inherit from NOG: Mediates binding to human platelets, possibly through a receptor-ligand interaction. Probably associated with virulence in endovascular infection (By similarity) 12CMI Cluster_199880 V1216985 M NLP P60 protein COG0791 Cluster_144214 V1216986 S NA 0YHMP Cluster_196146 V1216987 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_384099 V1216988 S NA 11MYY Cluster_261669 V1216989 RECB L recb family COG2887 Cluster_126097 V1216990 DCUA map02020 O Anaerobic c4-dicarboxylate transporter COG2704 Cluster_97353 V1216991 ASPA map00250,map00910,map01100 E Aspartate ammonia-lyase COG1027 Cluster_176126 V1216992 SERB1 E HAD-superfamily subfamily IB hydrolase COG0560 Cluster_102251 V1216993 HEMA map00860,map01100,map01110 H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) COG0373 Cluster_68559 V1216994 HEMD map00860,map01100,map01110 H synthase COG1587 Cluster_287326 V1217003 NHAP P Na H antiporter COG0025 Cluster_10724 V1217004 S conserved repeat domain protein 0ZW39 Cluster_67520 V1217009 YJJK S ABC transporter, ATP-binding protein COG0488 Cluster_110740 V1217012 K Transcriptional regulator GntR family COG1167 Cluster_269734 V1217013 PDXS map00750 H Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) COG0214 Cluster_252739 V1217014 L Membrane COG4905 Cluster_166880 V1217015 NIFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_295432 V1217016 SOJ D Chromosome Partitioning Protein COG1192 Cluster_416139 V1217017 M cell wall-binding protein COG2247 Cluster_10769 V1217019 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_217330 V1217020 NQRB C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG1805 Cluster_405369 V1217021 RNFG S FMN-binding domain-containing protein 12937 Cluster_399995 V1217022 NQRD C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG1347 Cluster_417940 V1217023 NQRE C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG2209 Cluster_469334 V1217025 MENA map00130,map01100,map01110 H 1,4-dihydroxy-2-naphthoate octaprenyltransferase COG1575 Cluster_169458 V1217026 MENE map00130,map01100,map01110 H o-succinylbenzoic acid-CoA ligase COG0318 Cluster_375279 V1217027 MSRA O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) COG0225 Cluster_160373 V1217028 S Membrane COG3949 Cluster_329084 V1217030 STPC map02010 V ABC, transporter COG1131 Cluster_347318 V1217031 T Two component transcriptional regulator luxr family COG2197 Cluster_147283 V1217032 SCLAV_2731 T Histidine kinase 11T0E Cluster_405370 V1217033 ALKB L Alkylated DNA repair protein COG3145 Cluster_208350 V1217034 SELU S Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) COG2603 Cluster_53783 V1217035 M Sulfatase COG1368 Cluster_225502 V1217036 S NA 0ZSFH Cluster_162037 V1217037 U Pfam:GSPII_E COG4962 Cluster_385862 V1217038 MT3758 U Type ii secretion system COG4965 Cluster_377047 V1217039 U type ii secretion system 123KS Cluster_718196 V1217040 RV3656C S NA 12265 Cluster_27094 V1217042 MT3751 L Helicase COG1205 Cluster_276392 V1217043 K, T Phage shock protein A COG1842 Cluster_279057 V1217044 HPAF map00350,map01100,map01120 Q Fumarylacetoacetate hydrolase COG0179 Cluster_76766 V1217045 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_540109 V1217046 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_59587 V1217047 HSDM V type I restriction-modification system COG0286 Cluster_176127 V1217048 PUCG map00250,map00260,map00630,map00680,map01100,map01110,map01120,map04146 E Aminotransferase COG0075 Cluster_259040 V1217050 S copper amine 121X1 Cluster_419711 V1217051 O Tryp_SPc 0YAAN Cluster_120619 V1217052 GLTT E glutamate COG0786 Cluster_74813 V1217054 S Relaxase/Mobilisation nuclease domain 0YUGU Cluster_138235 V1217057 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_699174 V1217058 J CRS1 / YhbY (CRM) domain COG1534 Cluster_460904 V1217059 RSMI G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 Cluster_67521 V1217060 BETP P Transporter COG1292 Cluster_138236 V1217061 PABB map00400,map00790,map01100,map01110,map01230 E, H synthase component I COG0147 Cluster_289976 V1217062 TATD L Hydrolase, tatD family COG0084 Cluster_318420 V1217063 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_460905 V1217064 S Abortive infection protein AbiGII 0XQHH Cluster_487255 V1217066 FOLA map00670,map00790,map01100 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) COG0262 Cluster_284480 V1217067 THYA map00240,map00670,map01100 F Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) COG0207 Cluster_322948 V1217068 CYSQ map00920,map01100,map01120 P inositol mono-phosphatase COG1218 Cluster_199881 V1217069 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120 G phosphohexose isomerase COG0166 Cluster_91375 V1217070 YEEE O YeeE YedE family protein COG2391 Cluster_230087 V1217071 S NA 0YHWM Cluster_316851 V1217072 PCS map00564 I Phosphatidylcholine synthase COG1183 Cluster_82540 V1217073 GABD2 map00010,map00040,map00053,map00071,map00250,map00280,map00310,map00330,map00340,map00350,map00360,map00380,map00410,map00561,map00620,map00625,map00640,map00643,map00650,map00903,map01100,map01110,map01120 C Dehydrogenase COG1012 Cluster_465111 V1217074 GREA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) COG0782 Cluster_446979 V1217075 LEGAS_1040 L transposase COG2963 Cluster_816897 V1217076 S NA 0Z7SI Cluster_365293 V1217077 K Transcriptional regulator 123QU Cluster_306554 V1217078 UBIE map00340,map00350,map00624,map01120 Q methyltransferase COG0500 Cluster_520368 V1217079 LYTR1 K TRANSCRIPTIONal COG1316 Cluster_731451 V1217080 O hydrogenase 12C73 Cluster_116287 V1217081 HOXH map00680 C Nickel-dependent hydrogenase large subunit COG3259 Cluster_385863 V1217082 O maturation protease COG0680 Cluster_60650 V1217083 HYAB map00633,map01120 C Hydrogenase, large subunit COG0374 Cluster_171145 V1217084 HYAA map00633,map01120 C small subunit COG1740 Cluster_200885 V1217085 MAZG map00230,map00240,map01100 F mazG family COG1694 Cluster_335039 V1217086 LPQU M MemBrane-bound lytic murein transglycosylase COG2951 Cluster_219620 V1217087 PPX map00230 F, P ppx gppa phosphatase COG0248 Cluster_399996 V1217088 GABD2 map00010,map00040,map00053,map00071,map00250,map00280,map00310,map00330,map00340,map00350,map00360,map00380,map00410,map00561,map00620,map00625,map00640,map00643,map00650,map00903,map01100,map01110,map01120 C Dehydrogenase COG1012 Cluster_226627 V1217089 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_148078 V1217090 P peroxidase COG2837 Cluster_414355 V1217091 P CopC domain COG2372 Cluster_232423 V1217092 YWQG S Domain of unknown function (DUF1963) COG3878 Cluster_89058 V1217095 S Radical SAM superfamily COG0641 Cluster_442959 V1217096 MT1019 S saf domain-containing protein 122V5 Cluster_365294 V1217097 FTHC map00670,map01100 H 5-formyltetrahydrofolate cyclo-ligase COG0212 Cluster_136684 V1217098 MOEA H Molybdenum cofactor synthesis domain protein COG0303 Cluster_417941 V1217099 RIMJ J N-acetyltransferase COG1670 Cluster_136685 V1217100 MT1025 S conserved transmembrane protein 12614 Cluster_309280 V1217101 S Membrane COG5660 Cluster_256433 V1217102 PMT M glycosyl transferase, family 39 COG1928 Cluster_85912 V1217103 COMM O Mg chelatase subunit ChlI COG0606 Cluster_97878 V1217104 GSPE map03070 U type ii secretion system protein e COG2804 Cluster_579511 V1217105 map02020,map03070 U Prokaryotic N-terminal methylation motif 0ZR0Y Cluster_423371 V1217106 PILD N, O, U Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) COG1989 Cluster_152879 V1217107 S NA 0YCC9 Cluster_32706 V1217111 S RNA ligase COG5324 Cluster_10137 V1217113 S Cell surface protein 0ZXQA Cluster_119122 V1217115 YOCR P transporter COG0733 Cluster_203968 V1217116 GRDB S Selenoprotein B, glycine betaine sarcosine D-proline reductase family 0XPCF Cluster_132641 V1217117 S reductase 0XPPI Cluster_321382 V1217118 YOAP S acetyltransferase, (GNAT) family 0XRCP Cluster_7123 V1217119 SURB S G5 domain protein 0ZVV3 Cluster_355392 V1217122 S NA 12433 Cluster_67522 V1217125 YDCQ D ftsk SpoIIIE family protein COG1674 Cluster_245152 V1217131 RIBF map00740,map01100 H riboflavin biosynthesis protein ribF COG0196 Cluster_34910 V1217132 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_531620 V1217133 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_449002 V1217134 PGSA map00564,map01100 I cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase COG0558 Cluster_187316 V1217135 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_95702 V1217136 SLGD_00064 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_333537 V1217137 map02010 P Cobalt transport protein COG0619 Cluster_152045 V1217138 YCSG P transporter COG1914 Cluster_350553 V1217139 KIPI map00330,map00791,map01100,map01120 E Allophanate hydrolase, subunit 1 COG2049 Cluster_262962 V1217140 MT0276 E urea amidolyase related protein COG1984 Cluster_499768 V1217141 ELAA S gCN5-related N-acetyltransferase COG2153 Cluster_92813 V1217142 PNTB map00760,map01100 C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) COG1282 Cluster_77124 V1217143 map00760,map01100 C NAD(P) transhydrogenase (Alpha subunit COG3288 Cluster_592608 V1217144 BH0416 L Transposase COG3464 Cluster_28763 V1217145 THRC map00260,map00750,map01100,map01120,map01230 E Threonine synthase COG0498 Cluster_160374 V1217146 HOM map00260,map00270,map00300,map01100,map01110,map01120,map01230 E homoserine dehydrogenase COG0460 Cluster_224324 V1217147 ASD map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) COG0136 Cluster_126798 V1217148 YCLM map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Aspartokinase COG0527 Cluster_281704 V1217149 P cation diffusion facilitator family transporter COG0053 Cluster_148821 V1217150 NLPD M peptidase M23 COG0739 Cluster_360417 V1217151 FTSE map02010 D Cell division ATP-binding protein ftsE COG2884 Cluster_279058 V1217152 V (ABC) transporter COG1131 Cluster_170320 V1217153 S Membrane COG0628 Cluster_434886 V1217154 EFP J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) COG0231 Cluster_551891 V1217155 YLQF K Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) COG1161 Cluster_665444 V1217156 RIBH map00740,map01100 H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) COG0054 Cluster_171146 V1217157 RIBD map00740,map01100 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) COG1985 Cluster_341000 V1217158 S membrane 11HPM Cluster_357082 V1217160 J Glutamine amidotransferase COG2071 Cluster_251526 V1217161 E, G EamA-like transporter family COG0697 Cluster_237288 V1217162 MSRA O reductase COG0229 Cluster_142767 V1217164 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_192593 V1217165 PRFA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) COG0216 Cluster_305164 V1217166 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_257716 V1217167 YQHQ J Metal-dependent enzyme COG3872 Cluster_360418 V1217168 O Cytochrome c biogenesis protein COG0785 Cluster_401783 V1217169 S Thioredoxin 12AE3 Cluster_446980 V1217170 RAIA J ribosomal subunit Interface protein COG1544 Cluster_728144 V1217171 S Copper-sensing transcriptional repressor CsoR COG1937 Cluster_27181 V1217172 COPA P p-type ATPase COG2217 Cluster_97354 V1217173 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_456886 V1217174 APT map00230,map01100 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) COG0503 Cluster_554752 V1217175 PEPN map00480,map01100 E aminopeptidase N COG0308 Cluster_385864 V1217176 G SMI1 / KNR4 family (SUKH-1) COG4282 Cluster_382318 V1217177 Q DSBA oxidoreductase 0ZVBB Cluster_130335 V1217178 PQQE K radical SAM domain protein COG0535 Cluster_494598 V1217179 RPIB map00030,map00710,map01100,map01110,map01120,map01230 G Ribose/Galactose Isomerase COG0698 Cluster_264346 V1217180 S NA 11FQQ Cluster_85535 V1217182 BGLA map00460,map00500,map00940,map01100,map01110 G ec 3.2.1.21 COG2723 Cluster_657039 V1217183 G Major Facilitator superfamily 0XP3M Cluster_606780 V1217184 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_165332 V1217185 HEMN map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_53512 V1217186 FADD3 map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG1022 Cluster_31614 V1217187 MALQ map00500,map01100 G 4-alpha-glucanotransferase COG1640 Cluster_636888 V1217189 PADR K Transcriptional regulator COG1695 Cluster_162884 V1217190 PLDB map00561,map00564,map01100,map04723 I Alpha Beta Hydrolase Fold protein COG2267 Cluster_80967 V1217191 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_326023 V1217192 GLPF G glycerol uptake facilitator protein COG0580 Cluster_56499 V1217193 GLPD map00564 C Glycerol-3-phosphate dehydrogenase COG0578 Cluster_492114 V1217194 TRMB C Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_53276 V1217198 PCKG map00010,map00020,map00620,map01100,map01110,map01120,map03320,map04151,map04910,map04920,map04964 C Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) COG1274 Cluster_494599 V1217199 NSRR map05132 K Transcriptional regulator COG1959 Cluster_156101 V1217200 HMP map05132 C nitric oxide dioxygenase (EC 1.14.12.17) COG1018 Cluster_249045 V1217201 map00910 S 2-Nitropropane dioxygenase COG2070 Cluster_133478 V1217202 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_129611 V1217203 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_63181 V1217204 G domain protein 11V8D Cluster_10627 V1217205 S NA 0XPXX Cluster_332047 V1217206 D ftsk SpoIIIE family protein COG1674 Cluster_596091 V1217210 HINDVM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_189017 V1217213 AFTC S integral membrane protein 0XT56 Cluster_449003 V1217217 SPOVK O AAA ATPase, central domain protein COG0464 Cluster_509869 V1217218 FPRA map00250,map00910,map01100,map01110,map01120,map01230 C reductase COG0493 Cluster_315326 V1217219 H cobalamin (vitamin b12) biosynthesis cbix protein COG2138 Cluster_152046 V1217220 CYSN map00230,map00450,map00920,map01100,map01120 P may be the GTPase, regulating ATP sulfurylase activity (By similarity) COG2895 Cluster_245153 V1217221 CYSD map00230,map00450,map00920,map01100,map01120 P sulfate adenylyltransferase), subunit 2 COG0175 Cluster_64574 V1217222 NIRA map00910,map00920,map01100,map01120 C Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) COG0155 Cluster_9809 V1217223 S VWA 11VQQ Cluster_213815 V1217225 M Cell wall anchor domain protein 0YMXG Cluster_316852 V1217226 S ABC, transporter COG1123 Cluster_234891 V1217227 SCLAV_5590 S ABC, transporter 11FMH Cluster_285919 V1217228 DPPC map02010 P ABC transporter COG1173 Cluster_239877 V1217229 DPPB P Binding-protein-dependent transport systems inner membrane component COG0601 Cluster_70235 V1217230 SCLAV_5587 E Extracellular solute-binding protein, family 5 COG0747 Cluster_245154 V1217231 PDXY map00750,map01100 H functions in a salvage pathway. Uses pyridoxamine (By similarity) COG2240 Cluster_520369 V1217232 YAEJ J class I peptide chain release factor COG1186 Cluster_273708 V1217233 YPFJ S zinc metallopeptidase COG2321 Cluster_118399 V1217235 PFLB map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_88116 V1217236 PFLA O Pyruvate formate-lyase COG1180 Cluster_545934 V1217237 S NA 0Y5YX Cluster_275061 V1217238 YIHY S ribonuclease BN COG1295 Cluster_188175 V1217239 K regulatoR COG3835 Cluster_174517 V1217240 GLXK map00260,map00561,map00630,map01100,map01110 G Glycerate kinase COG1929 Cluster_138237 V1217241 GNTT2 E, G gntp family COG2610 Cluster_179497 V1217242 map02010 S ABC-2 type transporter 11HPT Cluster_507282 V1217243 DRAG O ADP-ribosylation crystallin J1 COG1397 Cluster_66576 V1217244 E oligoendopeptidase, m3 family COG1164 Cluster_114876 V1217245 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_279059 V1217246 C nitrilase cyanide hydratase and apolipoprotein n-acyltransferase COG0388 Cluster_80161 V1217248 S Pfam:DUF1023 11GG7 Cluster_156102 V1217249 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_416140 V1217250 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_225503 V1217251 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_199882 V1217252 DINB L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity) COG0389 Cluster_202931 V1217253 S NA 124W6 Cluster_135063 V1217254 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01230 G phosphohexose isomerase COG0166 Cluster_482661 V1217255 COAD map00770,map01100 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) COG0669 Cluster_432964 V1217256 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_40386 V1217257 RECG map03440 L ATP-dependent DNA helicase recg COG1200 Cluster_73147 V1217258 YLOV S dak2 domain fusion protein ylov COG1461 Cluster_785209 V1217259 RPMB map03010 J 50S ribosomal protein l28 COG0227 Cluster_389407 V1217260 THIN map00730,map01100 H thiamine COG1564 Cluster_446981 V1217261 THIT S Proton-coupled thiamine transporter YuaJ COG3859 Cluster_512448 V1217262 NRDR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) COG1327 Cluster_130336 V1217263 RARA L recombination factor protein RarA COG2256 Cluster_109425 V1217264 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_816898 V1217265 XIS S DNA binding domain protein, excisionase family 121Y0 Cluster_296773 V1217266 PROC map00330,map01100,map01110,map01230 E pyrroline-5-carboxylate reductase COG0345 Cluster_102796 V1217267 S Membrane 0XTQ0 Cluster_260343 V1217268 PPX1 map00230 F, P ppx gppa phosphatase COG0248 Cluster_305166 V1217269 RV0495C S NA 0ZV27 Cluster_127488 V1217270 SENX3 map02020 T Histidine kinase 0XNMH Cluster_160375 V1217272 E Aminotransferase COG0436 Cluster_107049 V1217273 ABGB E aminobenzoyl-glutamate utilization protein B COG1473 Cluster_246477 V1217274 GLSA map00250,map00330,map00471,map00910,map01100,map01120,map04724,map04727,map04964 E Glutaminase COG2066 Cluster_380551 V1217275 S Membrane 11U5A Cluster_252740 V1217276 SCLAV_4470 map00561,map01100 S Triacylglycerol lipase COG1075 Cluster_88570 V1217278 S Conserved domain protein 0XZV4 Cluster_124093 V1217280 METY map00270,map01100 E O-Acetylhomoserine COG2873 Cluster_31505 V1217281 ICD map00020,map00480,map00720,map01100,map01110,map01120,map01210,map01230,map04146 C Isocitrate dehydrogenase COG2838 Cluster_126799 V1217283 CG0772 G Major Facilitator COG2814 Cluster_494600 V1217284 PPA map00190 C pyrophosphate phospho-hydrolase COG0221 Cluster_692087 V1217285 P Rhodanese-like domain 121TY Cluster_4653 V1217286 NPSC Q amino acid adenylation domain protein COG1020 Cluster_149587 V1217287 G Major Facilitator COG0477 Cluster_195298 V1217288 S Zinc finger, swim domain protein COG4279 Cluster_17887 V1217289 RV1278 S growth 0ZW9I Cluster_172874 V1217290 map02010 P Periplasmic binding protein COG0614 Cluster_40387 V1217291 GLTB map00250,map00630,map00910,map01100,map01110,map01120,map01230 E Glutamate synthase COG0070 Cluster_284481 V1217292 S Pfam:DUF1994 0XRWZ Cluster_65393 V1217293 FADD2 Q Acyl-CoA synthetase COG0318 Cluster_335040 V1217294 I, Q Short chain dehydrogenase COG1028 Cluster_319899 V1217295 SDH map00240,map01100 L Dehydrogenase COG4221 Cluster_212692 V1217296 P TrkA-N domain protein COG1226 Cluster_352053 V1217297 PURC map00230,map01100,map01110 F SAICAR synthetase COG0152 Cluster_118400 V1217298 PURF map00230,map00250,map01100,map01110 F glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_88117 V1217299 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_140508 V1217300 UVRD2 map03420,map03430 L helicase COG2887 Cluster_8467 V1217301 MT3296 L helicase COG2887 Cluster_183800 V1217302 S NA 11KMG Cluster_84712 V1217303 KATA map00380,map00630,map01110,map04146,map05014 P catalase COG0753 Cluster_487256 V1217305 MNHE P monovalent cation H antiporter subunit E COG1863 Cluster_380552 V1217306 MNHD P subunit D COG0651 Cluster_487257 V1217307 PHAC map00190,map00910,map01100 P Monovalent cation H antiporter subunit C COG1006 Cluster_10168 V1217308 MRPA map00190 P monovalent cation H antiporter subunit A COG2111 Cluster_469335 V1217309 S NA 17B7U@proNOG Cluster_287327 V1217310 UBIE map00340,map00350,map00624,map01120 Q methyltransferase COG0500 Cluster_614089 V1217311 S Cupin 2, conserved barrel domain protein COG1917 Cluster_153651 V1217313 HRRS T Histidine kinase 0XNMH Cluster_191663 V1217314 YXEA map02010 V ABC transporter, permease COG0577 Cluster_377048 V1217315 ORN map03008 A 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) COG1949 Cluster_296774 V1217316 SCLAV_0509 S Cytochrome c oxidase caa3-type, assembly factor ctag-related protein COG3336 Cluster_11281 V1217317 BL03512 M phage tail tape measure protein COG5283 Cluster_105187 V1217318 S NA 0Y87T Cluster_42597 V1217319 YYBT T domain protein COG3887 Cluster_60961 V1217320 LPQB S lipoprotein lpqb 0ZF99 Cluster_185557 V1217323 BMPA S basic membrane COG1744 Cluster_196147 V1217324 POTD map02010 E ABC transporter COG0687 Cluster_824677 V1217325 NRNA J phosphoesterase RecJ domain protein COG0618 Cluster_318421 V1217330 MEPA M peptidase COG0739 Cluster_125408 V1217332 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L DNA polymerase COG0749 Cluster_531621 V1217333 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_256434 V1217334 O Erythromycin esterase COG2312 Cluster_377049 V1217335 T cyclic nucleotide-binding domain protein COG0664 Cluster_69257 V1217336 HCP C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) COG1151 Cluster_91859 V1217337 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_318422 V1217338 S Protein of unknwon function (DUF2893) 10NS1 Cluster_125409 V1217339 S Phage integrase family 0ZK4N Cluster_836121 V1217340 LTRA L reverse transcriptase COG3344 Cluster_55244 V1217341 TRES map00500,map01100 G Trehalose synthase COG0366 Cluster_110741 V1217342 S domain protein COG3428 Cluster_482662 V1217343 S membrane-flanked domain protein COG3402 Cluster_114197 V1217344 I Carboxylesterase COG2272 Cluster_160376 V1217345 FEOB P Ferrous iron transport protein B COG0370 Cluster_246478 V1217346 DAPF map00300,map01100,map01110,map01120,map01230 E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) COG0253 Cluster_145713 V1217347 MT2802 S atpase involved in dna repair 0XNTH Cluster_131892 V1217349 HFLX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COG2262 Cluster_699175 V1217350 RPLW map03010 J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) COG0089 Cluster_391140 V1217351 RPLC map03010 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 Cluster_450977 V1217352 S Membrane 123WC Cluster_28252 V1217353 S Phage infection protein COG1511 Cluster_54751 V1217354 LEUA map00290,map00620,map01100,map01110,map01210,map01230 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) COG0119 Cluster_147284 V1217355 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_56500 V1217356 LMRA V ABC transporter transmembrane region COG1132 Cluster_59588 V1217357 V ABC transporter, ATP-binding protein COG1132 Cluster_492115 V1217358 RMAH K Transcriptional regulator, MarR family 0XUB6 Cluster_444940 V1217359 map00230 F Adenylate cyclase COG1437 Cluster_38833 V1217360 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_296775 V1217361 RPSB map03010 J 30S ribosomal protein S2 COG0052 Cluster_365296 V1217362 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_341001 V1217363 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_434887 V1217364 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_156948 V1217365 ASPC map00250,map00290,map01100,map01110,map01210,map01230 E Aminotransferase COG0436 Cluster_90911 V1217366 SSCG_04100 S YibE F family protein COG5438 Cluster_110055 V1217367 UDGA map00040,map00053,map00500,map00520,map01100,map01110 M Udp-glucose 6-dehydrogenase COG1004 Cluster_401784 V1217368 DCD map00240,map01100 F deoxycytidine triphosphate deaminase COG0717 Cluster_380553 V1217369 T regulatoR COG2197 Cluster_360419 V1217370 T Two-component system sensor kinase COG4564 Cluster_674143 V1217371 XASA E amino acid COG0531 Cluster_80968 V1217372 S fad dependent oxidoreductase COG2509 Cluster_134263 V1217373 S NA 0ZKMT Cluster_261670 V1217374 V (ABC) transporter 0XQRE Cluster_195299 V1217375 T Histidine kinase COG0642 Cluster_224325 V1217376 SP_0986 S Membrane COG2035 Cluster_15364 V1217377 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_94687 V1217378 RPSA map00900,map01100,map01110,map03010 J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) COG0539 Cluster_224326 V1217379 S YbbR-like protein COG4856 Cluster_281706 V1217380 YBBP S TIGR00159 family COG1624 Cluster_199883 V1217381 MBL D Rod shape-determining protein mreb COG1077 Cluster_489615 V1217382 ISPF map00900,map01100,map01110 I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) COG0245 Cluster_353717 V1217383 ISPD map00900,map01100,map01110 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COG1211 Cluster_100011 V1217386 SARE_3718 S Terminase 11NCI Cluster_97879 V1217387 S Phage portal protein, SPP1 Gp6-like 11J8D Cluster_805089 V1217390 S Structural protein 11PKS Cluster_407059 V1217391 MT0948 L resolvase COG2452 Cluster_108181 V1217392 L transposase IS605 OrfB family 0ZUWF Cluster_71232 V1217393 S NA 0ZT45 Cluster_79479 V1217399 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_186479 V1217401 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_61808 V1217402 POXB map00620,map01100 C pyruvate dehydrogenase COG0028 Cluster_489616 V1217403 RIMI S ribosomal-protein-alanine acetyltransferase COG0456 Cluster_603172 V1217404 YEAZ O Peptidase M22 Glycoprotease COG1214 Cluster_350554 V1217405 Q methyltransferase, type 11 COG0500 Cluster_223151 V1217406 S NA 11NX4 Cluster_348934 V1217407 J methyltransferase COG0566 Cluster_353718 V1217408 GPH map00630,map01100,map01110 S HAD-superfamily hydrolase subfamily IA COG0546 Cluster_322949 V1217409 FDHD C Necessary for formate dehydrogenase activity (By similarity) COG1526 Cluster_72481 V1217411 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_132642 V1217413 CCSB O Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) COG1333 Cluster_266983 V1217414 CCDA O cytochrome C biogenesis COG0785 Cluster_456888 V1217415 CCSX O Redoxin domain protein COG0526 Cluster_352054 V1217416 SCLAV_3539 G phosphoglycerate mutase COG0406 Cluster_118401 V1217417 HEML map00860,map01100,map01110 H Glutamate-1-semialdehyde aminotransferase COG0001 Cluster_154452 V1217418 APRE O Peptidase S8 and S53 subtilisin kexin sedolisin COG4412 Cluster_150447 V1217419 map02010 V (ABC) transporter COG1132 Cluster_382320 V1217420 PA5115 Q Methyltransferase 11IAU Cluster_130337 V1217421 PIP map00330 L Prolyl aminopeptidase COG0596 Cluster_184677 V1217422 S Membrane COG2860 Cluster_410674 V1217423 map00230 K, T Metal Dependent Phosphohydrolase COG0317 Cluster_182082 V1217424 YFMJ map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120 S Alcohol dehydrogenase zinc-binding domain protein COG2130 Cluster_342523 V1217425 G Major Facilitator superfamily 0XQFH Cluster_40546 V1217426 RV2345 S conserved transmembrane protein 11FRB Cluster_131121 V1217427 DGT map00230 F deoxyguanosinetriphosphate triphosphohydrolase-like protein COG0232 Cluster_471480 V1217428 BMUL_2753 F ribonuclease COG4290 Cluster_237289 V1217429 DNAG map03030 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 Cluster_253996 V1217430 NAGK G BadF BadG BcrA BcrD COG2971 Cluster_338115 V1217432 SLGD_00063 map02010 P Cobalt transport protein COG0619 Cluster_93745 V1217433 map02010 P ABC transporter COG1122 Cluster_60651 V1217434 V ABC transporter transmembrane region COG1132 Cluster_58543 V1217435 V ABC transporter COG1132 Cluster_35833 V1217436 F ATP cone domain COG1328 Cluster_231263 V1217437 M polysaccharide deacetylase COG0726 Cluster_162038 V1217438 CTPA M Carboxyl-terminal protease COG0793 Cluster_373564 V1217439 S NA 102FF Cluster_280361 V1217440 RBSK map00030 G ribokinase COG0524 Cluster_389408 V1217441 S NA 103AZ Cluster_280362 V1217442 map02010 P ABC transporter, permease COG1175 Cluster_91860 V1217443 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_252741 V1217445 USPA4 T Universal stress protein COG0589 Cluster_187317 V1217446 INO1 map00521,map00562,map01100,map01110 I synthase COG1260 Cluster_257717 V1217447 map00550,map01100 M glycosyl transferase, family 51 COG0744 Cluster_162039 V1217448 D Chromosome segregation protein SMC COG1196 Cluster_80580 V1217449 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_183801 V1217452 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_312249 V1217453 SURE map00230,map00240,map00760,map01100,map01110 F Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) COG0496 Cluster_307862 V1217454 VICX map03013 S domain protein COG1235 Cluster_279060 V1217455 S YycH protein 0ZZRJ Cluster_152880 V1217457 NATB C, P ABC transporter, permease COG1668 Cluster_161207 V1217458 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_867878 V1217459 SELB map00450,map00970 J Selenocysteine-specific translation elongation factor COG3276 Cluster_59073 V1217461 S NA 0Y392 Cluster_174518 V1217462 S NA 11M61 Cluster_221968 V1217463 YFEH G Bile acid COG0385 Cluster_401785 V1217464 TRPP S Membrane COG5658 Cluster_110056 V1217465 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_35429 V1217466 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_523147 V1217467 USPA3 T Universal stress protein COG0589 Cluster_303659 V1217471 map03420,map03430 L helicase COG3973 Cluster_266984 V1217472 YPUA S secreted protein COG4086 Cluster_408814 V1217474 E, H Thiamine pyrophosphate COG0028 Cluster_97355 V1217475 THRC map00260,map00750,map01100,map01120,map01230 E threonine synthase COG0498 Cluster_146511 V1217476 DCTP C symporter COG1301 Cluster_105805 V1217477 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_144966 V1217478 PTSI map02060 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) COG1080 Cluster_184678 V1217479 YKFB M mandelate racemase muconate lactonizing COG4948 Cluster_289977 V1217480 map00311,map00312,map01110,map02020 V Beta-lactamase COG2367 Cluster_363555 V1217482 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_238603 V1217483 RLUD J Pseudouridine synthase COG0564 Cluster_365297 V1217484 LYTB map00511 G endo-beta-N-acetylglucosaminidase COG4193 Cluster_357083 V1217485 NUC L nuclease COG1525 Cluster_232424 V1217486 YPUA S secreted protein COG4086 Cluster_97356 V1217487 T Histidine kinase 0XNMH Cluster_138238 V1217488 PRIA map03440 L Primosomal protein n' COG1198 Cluster_176950 V1217489 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_134264 V1217490 COABC map00770,map01100 H Phosphopantothenoylcysteine decarboxylase COG0452 Cluster_425157 V1217491 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG0194 Cluster_91861 V1217492 ACCD map00061,map00253,map00620,map00640,map00720,map01100,map01110,map01120 I carboxyl transferase COG0825 Cluster_257718 V1217494 RLUD J pseudouridine synthase COG0564 Cluster_192594 V1217495 MT3294 P TrkA-N domain protein COG1226 Cluster_414356 V1217496 S Metal Dependent Phosphohydrolase COG2316 Cluster_748085 V1217497 PAP L polyphosphate kinase 2 COG2326 Cluster_444941 V1217498 PAP L polyphosphate kinase 2 COG2326 Cluster_68560 V1217499 META map00270,map00920,map01100,map01110,map01230 E Homoserine O-transsuccinylase COG1897 Cluster_440945 V1217500 LPLA map00785,map01100 H Lipoate-protein ligase COG0095 Cluster_542987 V1217501 S DNA-binding protein with PD1-like DNA-binding motif COG1661 Cluster_489617 V1217502 YCIA map00903,map01040 I thioesterase Superfamily protein COG1607 Cluster_30582 V1217503 DNAQ map03022,map03420 L helicase COG1199 Cluster_205043 V1217504 LDCA V peptidase U61 LD-carboxypeptidase A COG1619 Cluster_90421 V1217505 GLCD map00620,map00630,map01100,map01110,map01120 C FAD linked oxidase domain-containing protein COG0277 Cluster_617863 V1217506 LRGA map02020 S lrga family COG1380 Cluster_162040 V1217507 THII map00730,map01100,map04122 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) COG0301 Cluster_175331 V1217508 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_401786 V1217510 S membrane 11UQ3 Cluster_589242 V1217511 map03070 U NA 0ZZV9 Cluster_115559 V1217513 K Inherit from COG: Transcriptional regulator COG2508 Cluster_178622 V1217514 S NA 1030P Cluster_281707 V1217516 MSHB S Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) COG2120 Cluster_39148 V1217517 LPQW E Extracellular solute-binding protein, family 5 COG0747 Cluster_47868 V1217518 TYPA T gtp-binding protein typa COG1217 Cluster_450978 V1217519 S NA 120AV Cluster_12796 V1217522 RV3193C S UPF0182 protein COG1615 Cluster_211608 V1217523 RESC O cytochrome C COG0755 Cluster_266985 V1217524 RFBA map00521,map00523,map01100,map01110 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) COG1209 Cluster_606782 V1217526 S Membrane 0Y2N2 Cluster_166140 V1217527 SCLAV_3679 S Alpha beta hydrolase fold COG0596 Cluster_196960 V1217529 S Acyltransferase family 12D68 Cluster_29303 V1217531 SECA2 map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_321383 V1217532 MERR1 K merr family transcriptional regulator COG0789 Cluster_408815 V1217533 RV1829 S nuclease activity COG1259 Cluster_108182 V1217534 U type iv secretory pathway vird4 protein-like protein 0YII6 Cluster_6568 V1217537 DPNA L helicase COG4646 Cluster_211609 V1217539 M polysaccharide deacetylase COG0726 Cluster_178623 V1217540 METE map00270,map00450,map01100,map01110,map01230 E Methionine synthase COG0620 Cluster_39301 V1217541 FUSA2 J Translation elongation factor COG0480 Cluster_332048 V1217542 MUTM map03410 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) COG0266 Cluster_336571 V1217543 RNC map03008,map05205 K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) COG0571 Cluster_432965 V1217544 YLBN S metal-binding protein COG1399 Cluster_319900 V1217545 RV2927C D growth COG3599 Cluster_34635 V1217546 RECG map03440 L ATP-dependent DNA helicase RecG COG1200 Cluster_596093 V1217547 RRGB M Lpxtg-motif cell wall anchor domain protein 0XSEP Cluster_1999 V1217548 CAFA map03018 J ribonuclease COG1530 Cluster_17294 V1217549 S Rib/alpha-like repeat 10008 Cluster_143465 V1217550 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_475729 V1217551 PURN map00230,map00670,map01100,map01110 F phosphoribosylglycinamide formyltransferase COG0299 Cluster_477934 V1217552 RUVC map03440 L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) COG0817 Cluster_217332 V1217553 ASNA map00250,map00460,map00910,map01100,map01110,map01230 E asparagine synthetase A COG2502 Cluster_265673 V1217558 S Protein of unknown function (DUF3102) 11VGJ Cluster_242526 V1217565 YQAJ L phage-type endonuclease COG5377 Cluster_259041 V1217566 RECT L recT protein COG3723 Cluster_396548 V1217567 S Phage replisome organizer 0ZW0Q Cluster_59883 V1217570 FADH map00633,map01120 C NADH flavin oxidoreductase NADH oxidase COG1902 Cluster_473594 V1217571 OGT L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) COG0350 Cluster_259042 V1217572 P cation diffusion facilitator family transporter COG0053 Cluster_99484 V1217573 HRPB L ATP-dependent helicase COG1643 Cluster_86819 V1217574 map03440 K Transcriptional regulator COG2865 Cluster_149588 V1217575 HSDS V type I restriction-modification system COG0732 Cluster_475730 V1217576 S Toxin-antitoxin system, toxin component, Fic family COG3943 Cluster_436936 V1217577 S DNA-binding protein COG3943 Cluster_257719 V1217578 HSDM V type I restriction-modification system COG0286 Cluster_391141 V1217579 CKL_0494 L transposase COG2801 Cluster_665445 V1217580 S Inherit from NOG: Toxin-antitoxin system, toxin component, RelE family 0Y0E0 Cluster_122152 V1217581 PBUX F permease COG2233 Cluster_38492 V1217582 T Histidine kinase COG0642 Cluster_277699 V1217584 L Dna topoisomerase COG0550 Cluster_517818 V1217585 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_190744 V1217586 PRFA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) COG0216 Cluster_237290 V1217587 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_382321 V1217588 SUA5 J sua5 ycio yrdc ywlc family protein COG0009 Cluster_144215 V1217589 RFE M Glycosyl transferase, family 4 COG0472 Cluster_398275 V1217590 RECX S Modulates RecA activity (By similarity) COG2137 Cluster_714953 V1217591 YAZA L domain protein COG2827 Cluster_614091 V1217592 RPLT map03010 J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) COG0292 Cluster_321384 V1217593 SPOU J rrna methyltransferase COG0566 Cluster_358753 V1217594 S NA 0ZVJP Cluster_471481 V1217595 S NA 0Z63U Cluster_48071 V1217596 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_497104 V1217597 L CT1975-like protein 0YBWR Cluster_449004 V1217598 L CRISPR-associated protein Cse2 (CRISPR_cse2) 0ZD9H Cluster_127490 V1217599 S NA 0YA7V Cluster_414357 V1217600 L CRISPR-Associated Protein 11NWW Cluster_20846 V1217601 CAS3 L CRISPR-associated helicase, cas3 COG1203 Cluster_14638 V1217603 EGYY_05010 U traE protein COG3451 Cluster_141263 V1217606 PITB P phosphate COG0306 Cluster_299458 V1217607 LIPB map00785,map01100 H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) COG0321 Cluster_195300 V1217608 LIPA map00785,map01100 H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) COG0320 Cluster_310719 V1217609 RV2219 S integral membrane protein 0Z3WW Cluster_72821 V1217610 P transport protein COG2985 Cluster_820697 V1217611 CG2428 S rdd domain containing protein 11WIF Cluster_371947 V1217612 ZNUC map02010 P (ABC) transporter COG1121 Cluster_237291 V1217613 ZNUA map02010 P periplasmic solute binding protein COG0803 Cluster_563695 V1217616 S Uncharacterised protein family (UPF0150) 0ZXU8 Cluster_373565 V1217617 BMUL_3003 S Membrane COG3619 Cluster_382322 V1217618 S NA 11XPU Cluster_104594 V1217619 V HNHc 0ZNS5 Cluster_540110 V1217620 SCLAV_4550 L UPF0102 protein COG0792 Cluster_84282 V1217621 COMM O Mg chelatase subunit ChlI COG0606 Cluster_432966 V1217622 P Chromate COG2059 Cluster_210469 V1217623 FECB map02010 P transport system permease protein COG0609 Cluster_368615 V1217624 BMUL_5652 L Transposase COG2801 Cluster_412491 V1217625 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_157813 V1217626 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_61809 V1217627 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_188176 V1217628 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_62084 V1217629 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_57022 V1217630 CAFA map03018 J ribonuclease COG1530 Cluster_414358 V1217631 ARSM map00130,map00340,map00350,map00624,map01100,map01110,map01120 S methyltransferase, type 11 0XSKB Cluster_678594 V1217632 K transcriptional regulator 11VCW Cluster_238604 V1217633 JAG S Single-stranded nucleic acid binding R3H domain-containing protein COG1847 Cluster_41382 V1217634 L adenine specific DNA methylase COG2189 Cluster_432967 V1217635 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_116288 V1217636 TILS D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) COG0037 Cluster_540111 V1217637 YABR J RNA binding s1 domain protein COG1098 Cluster_260344 V1217639 J HAD-superfamily hydrolase subfamily IA variant 3 COG0637 Cluster_221969 V1217640 PHOH T Phoh family COG1702 Cluster_504699 V1217641 YBEY map00240,map00983,map01100 F Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) COG0319 Cluster_389409 V1217642 S NA 11VIE Cluster_266986 V1217644 RLUC2 J pseudouridine synthase COG0564 Cluster_18859 V1217645 SCLAV_2230 V ABC, transporter COG0577 Cluster_520371 V1217646 S Short-chain dehydrogenase reductase sdr COG0300 Cluster_336572 V1217647 S NA 0ZCBM Cluster_6921 V1217648 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit alpha COG0587 Cluster_130338 V1217649 ILVA map00260,map00290,map01100,map01110,map01230 E Threonine dehydratase COG1171 Cluster_288681 V1217650 S NA 0ZN4K Cluster_184679 V1217651 S ABC transporter, ATPase COG3044 Cluster_306555 V1217652 TIPA K Transcriptional regulator COG0789 Cluster_307863 V1217654 NAGB map00520,map01100,map01110 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COG0363 Cluster_335041 V1217655 O ADP-ribosylation crystallin J1 COG1397 Cluster_781085 V1217656 S Protein of unknown function (DUF1648) 0YVE4 Cluster_51921 V1217657 L recombinase COG1961 Cluster_345741 V1217658 T Regulator COG0745 Cluster_13211 V1217659 ADDA L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation COG1074 Cluster_305167 V1217660 PLSC map00561,map00564,map01100 I Acyl-transferase COG0204 Cluster_167676 V1217661 PIMB M Glycosyl transferase (Group 1 COG0438 Cluster_208351 V1217662 CG2401 M Secreted protein COG0791 Cluster_212693 V1217663 S CAAX amino terminal protease family 0ZWQM Cluster_16938 V1217664 P ATPase, P-type transporting, HAD superfamily, subfamily IC COG0474 Cluster_504700 V1217666 CTSR K transcriptional regulator, ctsr COG4463 Cluster_152882 V1217667 APEB E M18 family aminopeptidase COG1362 Cluster_221970 V1217669 S Htaa 11VMG Cluster_137475 V1217670 THIC map00730,map01100 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) COG0422 Cluster_45569 V1217671 NTPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_403562 V1217679 DCM map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_762247 V1217680 S NA 0Y0CD Cluster_98963 V1217681 UMUC L ImpB MucB SamB family protein COG0389 Cluster_444942 V1217682 S Toxin-antitoxin system, toxin component 0XRRU Cluster_557675 V1217683 K DNA-binding helix-turn-helix protein 11XIQ Cluster_367002 V1217685 map02010 S YodA lipocalin-like domain 11KBP Cluster_103421 V1217686 AGCS E amino acid carrier protein COG1115 Cluster_73512 V1217687 HCP C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) COG1151 Cluster_289978 V1217688 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_136686 V1217689 SUN J ribosomal RNA small subunit methyltransferase COG0144 Cluster_197892 V1217690 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_83391 V1217691 S Domain of unknown function (DUF222) 11KRE Cluster_287328 V1217692 map00270,map01100,map04122 P sulfurtransferase COG2897 Cluster_45953 V1217693 MT0396 S Secreted protein 11RTG Cluster_526069 V1217694 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_124745 V1217696 PEPD map02020 O Peptidase s1 and s6 chymotrypsin hap COG0265 Cluster_80969 V1217697 MPRB map02020 T Histidine kinase COG0642 Cluster_230088 V1217699 MRAY map00550,map01100 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) COG0472 Cluster_123460 V1217700 MURD map00471,map00550,map01100 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COG0771 Cluster_180321 V1217701 FTSW map04112 D cell division protein COG0772 Cluster_179498 V1217702 MURG map00550,map01100,map04112 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) COG0707 Cluster_339548 V1217703 FTSQ map04112 M domain protein, FtsQ-type COG1589 Cluster_596094 V1217704 TNPR L Resolvase COG1961 Cluster_299459 V1217705 STRA J Aminoglycoside COG3231 Cluster_284482 V1217706 STRB V aminoglycoside hydroxyurea antibiotic resistance kinase COG3570 Cluster_162041 V1217707 G Chloramphenicol resistance protein COG2814 Cluster_427090 V1217708 L resolvase COG1961 Cluster_589244 V1217709 GRDX S grdx protein 1230X Cluster_105188 V1217710 SELA map00450,map00970 E Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) COG1921 Cluster_173710 V1217711 S Inherit from COG: Membrane COG3949 Cluster_160377 V1217712 HOM map00260,map00270,map00300,map01100,map01110,map01120,map01230 E homoserine dehydrogenase COG0460 Cluster_225504 V1217713 ASD map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) COG0136 Cluster_126800 V1217714 YCLM map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Aspartokinase COG0527 Cluster_95703 V1217716 GLNA map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG0174 Cluster_162885 V1217717 OCD map00270,map00330,map00920,map01100,map01110,map01120,map01230 E Ornithine Cyclodeaminase COG2423 Cluster_99485 V1217718 GLNA map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG0174 Cluster_11534 V1217721 SCLAV_2624 S NA 0YQAJ Cluster_603173 V1217722 S NA 0YJ8K Cluster_378824 V1217724 VANZ V VanZ-like protein COG4767 Cluster_699176 V1217725 HYPD O hydrogenase expression formation protein HypD COG0409 Cluster_272377 V1217726 CITE map00020,map01110,map02020 G Citrate lyase COG2301 Cluster_60141 V1217727 FADD35 map00071,map01100,map03320,map04146,map04920 Q Amp-dependent synthetase and ligase COG0318 Cluster_196961 V1217728 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_114198 V1217729 MURF map00300,map00550,map01100 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) COG0770 Cluster_360420 V1217730 YDJZ S SNARE associated Golgi protein-related protein COG0398 Cluster_138239 V1217731 GLTP C Transporter, dicarboxylate amino acid cation Na H symporter family protein COG1301 Cluster_440946 V1217732 TRPP S tryptophan transport protein 11UPK Cluster_313739 V1217733 UDP map00240,map00983,map01100 F Uridine phosphorylase COG2820 Cluster_333538 V1217734 RLMB map00340,map00350,map00624,map01120 J RNA methyltransferase TrmH family group 3 COG0566 Cluster_97880 V1217735 AMYA map00500,map01100,map04973 G Alpha-amylase COG0366 Cluster_403563 V1217736 RNHA map03030 S ribonuclease COG3341 Cluster_192595 V1217737 NUOG map00190,map00630,map00680,map00910,map01100,map01120 C oxidoreductase COG3383 Cluster_245155 V1217738 C NADH-ubiquinone oxidoreductase-G iron-sulfur binding region COG3383 Cluster_50158 V1217739 HYMB map00190,map00910,map01100 C NADH dehydrogenase COG1894 Cluster_484985 V1217740 NUOE map00190,map00910,map01100 C NADH dehydrogenase (Ubiquinone), 24 kDa subunit COG1905 Cluster_299460 V1217742 S Calcineurin-like phosphoesterase COG1408 Cluster_114199 V1217744 PYCB map00330,map00620,map01100 C Oxaloacetate decarboxylase COG5016 Cluster_41383 V1217747 U TraG family COG3505 Cluster_477935 V1217748 RIBX S Pfam:DUF2581 11VXH Cluster_196962 V1217749 RIBD map00740,map01100 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) COG1985 Cluster_368617 V1217750 RPE map00030,map00040,map00710,map01100,map01110,map01120,map01230 G ribulose-phosphate 3-epimerase COG0036 Cluster_83392 V1217752 ERIC P Chloride channel COG0038 Cluster_345742 V1217755 SRTA M (sortase) family COG3764 Cluster_385866 V1217761 RIMJ J N-acetyltransferase COG1670 Cluster_186480 V1217764 BL01373 L Integrase COG0582 Cluster_403564 V1217766 K Peptidase S24-like COG1974 Cluster_185558 V1217769 MURE map00300,map00550 M mur ligase COG0769 Cluster_233691 V1217771 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_135876 V1217772 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_280364 V1217773 PDXS map00750 H Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) COG0214 Cluster_327589 V1217774 CAUL_2856 map00051,map00140,map00363,map00591,map00625,map00650,map01100,map01120 S Short-chain dehydrogenase reductase Sdr COG1028 Cluster_103999 V1217775 GND map00030,map00480,map01100,map01110,map01120 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) COG0362 Cluster_105806 V1217777 S secreted peptidase 0Z6A1 Cluster_75164 V1217778 YEJH L type iii restriction protein res subunit COG1061 Cluster_318423 V1217779 Y3088 S regulatory prophage protein 16SGX@proNOG Cluster_13494 V1217780 Y3088 S regulatory prophage protein 16SGX@proNOG Cluster_540112 V1217781 FRUA map00051,map01100,map02060 G PTS System COG1762 Cluster_119123 V1217782 F Uracil permease COG2233 Cluster_170321 V1217783 MRPA map00190 P monovalent cation H antiporter subunit A COG2111 Cluster_114200 V1217785 GSPE map03070 U type ii secretion system protein e COG2804 Cluster_271046 V1217786 DKGA C reductase COG0656 Cluster_473595 V1217787 S ABC transporter COG4152 Cluster_384100 V1217788 NBCG_03603 S Protein of unknown function (DUF3027) 11G10 Cluster_15263 V1217791 ELRF S cutinase 11FQ6 Cluster_242527 V1217793 S Secretion protein snm4 0YE0Q Cluster_119124 V1217794 HLYX P Domain of unknown function DUF21 COG1253 Cluster_41694 V1217795 HPPA map00190 C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for COG3808 Cluster_542989 V1217796 C Flavodoxin COG0716 Cluster_449005 V1217797 NTPF S H -ATPase, subunit H 122TR Cluster_342525 V1217798 RNC map03008,map05205 K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) COG0571 Cluster_226628 V1217799 PLSX map00561,map00564,map01100 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) COG0416 Cluster_160378 V1217800 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_415802 V1021601 RNFE C Electron transport complex COG4660 Cluster_345418 V1021604 GLNE O, T Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) COG1391 Cluster_397951 V1021607 YCGM map00350,map01100,map01120 Q fumarylacetoacetate (faa) hydrolase COG0179 Cluster_430576 V1021610 MAF D MAF-like protein COG0424 Cluster_231053 V1021611 K RNA polymerase sigma-24 subunit, ECF subfamily 0ZKQ9 Cluster_428589 V1021622 LGAS_0609 S Phage minor structural protein GP20 123J7 Cluster_419282 V1021625 FKPB O peptidylprolyl cis-trans isomerase COG0545 Cluster_226423 V1021626 map02010 E PBPb COG0834 Cluster_436503 V1021629 S NA 11RDA Cluster_875047 V1021630 V Eco57I restriction-modification methylase COG1002 Cluster_321096 V1021632 LYTT map02020 T regulatoR COG3279 Cluster_895403 V1021633 LRGA map02020 S murein hydrolase regulator LrgA COG1380 Cluster_496545 V1021634 S lysozyme 0YC6U Cluster_484466 V1021635 S conjugative transposon protein TraQ 11SF8 Cluster_381955 V1021639 K Tetr family transcriptional regulator 11PAC Cluster_217107 V1021642 RECQ map03018 L ATP-dependent DNA helicase RecQ COG0514 Cluster_819697 V1021644 TNP3509A L Transposase for insertion sequence element 0Z3DP Cluster_406709 V1021646 RIBE map00740,map01100 H riboflavin synthase, subunit alpha COG0307 Cluster_128758 V1021647 S NA 1202A Cluster_698511 V1021652 S Protein of unknown function (DUF713) 0Y5I3 Cluster_908192 V1021653 SASC S surface protein 11FPX Cluster_261437 V1021654 SASC S surface protein 11FPX Cluster_285632 V1021655 SANA S SanA protein COG2949 Cluster_193278 V1021656 PURM map00230,map01100,map01110 F phosphoribosylaminoimidazole synthetase COG0150 Cluster_464690 V1021657 S NA 11USQ Cluster_188872 V1021661 L UvrD REP helicase COG0210 Cluster_413990 V1021663 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_528240 V1021664 S NA 0YSBG Cluster_299215 V1021665 CBIO1 map02010 P Abc transporter COG1122 Cluster_180168 V1021666 VIOA map00362,map00363,map00626,map00650,map00903,map01100,map01110,map01120 E DegT DnrJ EryC1 StrS COG0399 Cluster_501735 V1021670 RSMI G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 Cluster_460463 V1021672 RPSE map03010 J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) COG0098 Cluster_602320 V1021673 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_743924 V1021675 S NA 0ZHU9 Cluster_499198 V1021677 S Domain of unknown function (DUF1896) 11Y7P Cluster_331778 V1021681 map02010 V transporter COG0842 Cluster_424783 V1021682 ADK map00230,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_132496 V1021683 CLFA map05150 M Cell surface-associated protein implicated in virulence. Promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen. Induces formation of bacterial clumps 0Y59N Cluster_591853 V1021685 YOHJ S lrga family COG1380 Cluster_324229 V1021688 S NA 11PBC Cluster_289767 V1021689 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_281467 V1021691 RLUB J pseudouridine synthase COG1187 Cluster_164345 V1021692 DESA3 map00591,map01100 I Fatty Acid Desaturase COG3239 Cluster_134122 V1021693 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_613267 V1021694 AZO1 map00740,map01100 S Nadph-dependent fmn reductase COG0431 Cluster_575676 V1021696 S NA 11SIY Cluster_578761 V1021699 QUEC map00790,map01100 S Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) COG0603 Cluster_419283 V1021703 S NA 0ZHU9 Cluster_737193 V1021704 S NA 0XW3Z Cluster_353444 V1021705 S acidPPc 11ME9 Cluster_334726 V1021707 FTSE map02010 D Cell division ATP-binding protein ftsE COG2884 Cluster_145579 V1021708 M exopolysaccharide biosynthesis COG0489 Cluster_486780 V1021709 S membrane 11PB2 Cluster_181866 V1021710 BGAA map00052,map00511,map00600,map01100 G hydrolase, family 2 COG3250 Cluster_569254 V1021714 S NA 17D58@proNOG Cluster_253793 V1021715 S Pfam:DUF1812 0Y61M Cluster_260127 V1021716 QCRC map00190,map01100 C cytochrome C COG2010 Cluster_695142 V1021717 QCRA map00190,map00910,map01100,map02020,map04260,map05010,map05012,map05016 C c reductase, iron-sulfur COG0723 Cluster_243647 V1021718 L integrase family 0ZJHZ Cluster_454551 V1021719 S single-strand binding family protein 0XS6K Cluster_506672 V1021720 S NA 0ZEMC Cluster_769163 V1021721 GMD map00051,map00520,map01100 M Gdp-mannose 4,6-dehydratase COG1089 Cluster_360088 V1021722 BMUL_1176 S Peptidase M50 COG1994 Cluster_199689 V1021730 RC1_2786 L transposase COG5433 Cluster_176826 V1021731 MRPA map00190 P monovalent cation H antiporter subunit A COG2111 Cluster_136538 V1021732 map00020,map00310,map00380,map01100,map01110,map01120 C 2-oxoglutarate dehydrogenase, E1 subunit COG0567 Cluster_135737 V1021733 U, W Pfam:YadA COG5295 Cluster_747354 V1021734 FEOA P Ferrous iron transport protein A COG1918 Cluster_300550 V1021736 PHNB map02010 P phosphonate abc transporter COG3639 Cluster_136539 V1021737 HSDR V type I restriction-modification system COG0610 Cluster_479823 V1021740 MRA_2194 S NA 11IRB Cluster_473121 V1021741 MMSA map00280,map00410,map00562,map00640,map01100 I methylmalonate-semialdehyde dehydrogenase COG1012 Cluster_192442 V1021742 AARI_34710 L Transposase for insertion sequence 11IYJ Cluster_136540 V1021743 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_460464 V1021744 ISPF map00900,map01100,map01110 I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) COG0245 Cluster_137318 V1021748 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_202720 V1021749 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin 0XQTW Cluster_602321 V1021750 S NA 11SYG Cluster_287056 V1021752 CKL_0494 L transposase COG2801 Cluster_727358 V1021753 BBAL3_2090 L transposase COG2801 Cluster_442549 V1021755 K Tetr family transcriptional regulator 11SFF Cluster_213603 V1021756 COBT map00860,map01100 H Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) COG2038 Cluster_528241 V1021759 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_310434 V1021763 COBA map00860,map01100,map01110 H Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) COG0007 Cluster_380174 V1021766 ACNA map00020,map00300,map00630,map00720,map01100,map01110,map01120,map01210,map01230 C aconitate hydratase COG1048 Cluster_542258 V1021767 ARSC P arsenate reductase COG1393 Cluster_714236 V1021768 NRDA map00230,map00240,map00480,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_701612 V1021769 GALF_0732 L transposase, IS3 IS911 family protein 17PD7@proNOG Cluster_624493 V1021770 RPIC_1486 L IS66 Orf2 family protein 17EQY@proNOG Cluster_509299 V1021774 HSLR J Heat shock protein COG1188 Cluster_277459 V1021780 S NA 11KFV Cluster_904009 V1021783 S NA 0ZHU9 Cluster_450565 V1021784 RV1481 S von Willebrand factor, type A COG2304 Cluster_536674 V1021785 RV1480 S von Willebrand factor COG1721 Cluster_278837 V1021786 S Protein of unknown function (DUF2807) 0ZWQJ Cluster_221784 V1021787 S NA 0ZKFH Cluster_754163 V1021788 map03420,map03430 L helicase COG3973 Cluster_475250 V1021789 COAD map00770,map01100 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) COG0669 Cluster_295161 V1021790 NQRC C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG2869 Cluster_448586 V1021791 RBR C Rubrerythrin COG1592 Cluster_238355 V1021792 FLGJ map00511 N, U flagellar rod assembly protein muramidase flgj COG1705 Cluster_442550 V1021795 RIMM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) 11M4J Cluster_289768 V1021796 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_695143 V1021797 S Transglycosylase associated protein COG2261 Cluster_410676 V1217801 PLSY map00561,map00564,map01100 S Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) COG0344 Cluster_800883 V1217803 L Dna topoisomerase COG0550 Cluster_107050 V1217804 S NA 0Z34Z Cluster_62630 V1217806 MOP map00230,map01100,map01120 C Xanthine dehydrogenase COG2080 Cluster_26892 V1217807 PRIA map03440 L Primosomal protein n' COG1198 Cluster_669755 V1217808 S NA 11JEI Cluster_108183 V1217809 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_241154 V1217810 YHCC S Radical SAM Protein COG1242 Cluster_531622 V1217811 S NA 121S9 Cluster_21406 V1217814 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_614092 V1217815 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_566887 V1217816 RPSH map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) COG0096 Cluster_127491 V1217817 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_291290 V1217818 BMUL_5652 L Transposase COG2801 Cluster_34351 V1217820 S Lpxtg-motif cell wall anchor domain protein 0XQBH Cluster_425158 V1217821 YQEK map00760,map01100 H Metal Dependent Phosphohydrolase COG1713 Cluster_419712 V1217822 S integral membrane protein 11P1U Cluster_714954 V1217823 map00630,map01100 G Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) COG3622 Cluster_335042 V1217824 OCAR_5505 S Short-chain dehydrogenase reductase Sdr 0XNT1 Cluster_146512 V1217825 ENTC map00130,map01053,map01100,map01110 H Isochorismate synthase COG1169 Cluster_306556 V1217826 FAHA Q 5-carboxymethyl-2-hydroxymuconate Delta-isomerase (EC 5.3.3.10) COG0179 Cluster_77125 V1217827 VP1725 T cbs domain and cyclic nucleotide-regulated nucleotidyltransferase COG2905 Cluster_165333 V1217828 S NA 0Z6MD Cluster_341002 V1217829 S Filamentation induced by cAMP protein fic COG3177 Cluster_16440 V1217830 S s-layer domain-containing protein 11ZJU Cluster_193480 V1217831 CSAB M Polysaccharide pyruvyl transferase COG2327 Cluster_394763 V1217832 MSHD S Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) COG0456 Cluster_183802 V1217833 PSTS map02010,map02020,map05152 P Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) COG0226 Cluster_188177 V1217835 M glycosyl transferase group 1 COG0438 Cluster_161208 V1217836 PGLE E DegT DnrJ EryC1 StrS aminotransferase COG0399 Cluster_382324 V1217838 PGLB M sugar transferase COG2148 Cluster_446982 V1217839 map00350,map00362,map00627,map00642,map00903,map01120 S Transferase COG0110 Cluster_2435 V1217840 S NA 101UU Cluster_65103 V1217841 CRTI map00906,map01100,map01110 Q phytoene COG1233 Cluster_179499 V1217842 IDSA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_245156 V1217843 METF map00670,map00720,map01100,map01120 E Methylenetetrahydrofolate reductase COG0685 Cluster_405372 V1217844 LPPM S (LipO)protein 11TZC Cluster_32707 V1217845 F ATP cone domain COG1328 Cluster_103422 V1217846 S Pfam:DUF571 101QY Cluster_144967 V1217847 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_487258 V1217848 map00190,map00910,map01100 C hydrogenase) (Fe-only COG4624 Cluster_171966 V1217849 S YibE F family protein COG5438 Cluster_239878 V1217851 OPPF map02010 E ABC superfamily ATP binding cassette transporter ABC protein COG4608 Cluster_227758 V1217852 OPPB E, P Oligopeptide ABC transporter, permease protein AppB COG0601 Cluster_247738 V1217853 APPC map02010 P ABC superfamily ATP binding cassette transporter ABC protein COG1173 Cluster_13250 V1217854 PITRM1 O peptidase COG1026 Cluster_319901 V1217855 XTH map03410 L Exodeoxyribonuclease III COG0708 Cluster_436938 V1217856 TATB map03060,map03070 U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) COG1826 Cluster_124746 V1217857 HTRA map02020 O Peptidase s1 and s6 chymotrypsin hap COG0265 Cluster_377050 V1217858 SIGE K RNA polymerase COG1595 Cluster_515150 V1217859 SMPB O Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) COG0691 Cluster_61810 V1217860 FBPA K Fibronectin-binding protein COG1293 Cluster_724875 V1217861 YLZA S UPF0296 protein COG2052 Cluster_494601 V1217862 PURE map00230,map01100,map01110 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) COG0041 Cluster_206119 V1217863 PURM map00230,map01100,map01110 F phosphoribosylaminoimidazole synthetase COG0150 Cluster_76424 V1217864 YBIT S ABC transporter, ATP-binding protein COG0488 Cluster_87687 V1217865 GATB map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 Cluster_124747 V1217868 P NA 1834U@proNOG Cluster_269735 V1217869 P Siderophore-interacting protein COG2375 Cluster_7527 V1217870 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_310720 V1217872 map02010 P ABC transporter COG1131 Cluster_387709 V1217873 S integral membrane protein 11PE6 Cluster_107630 V1217874 SCLAV_4353 T Histidine kinase 11H4Z Cluster_367003 V1217875 T Two component transcriptional regulator, LuxR family COG2197 Cluster_271047 V1217876 C radical SAM domain protein COG1032 Cluster_96289 V1217877 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_221971 V1217878 YTQA S Radical SAM Protein COG1242 Cluster_292648 V1217879 HYPD O hydrogenase expression formation protein HypD COG0409 Cluster_171147 V1217880 HYPE O hydrogenase expression formation protein (HypE) COG0309 Cluster_24917 V1217881 HYPF O hydrogenase maturation protein Hypf COG0068 Cluster_399997 V1217882 THIN map00730,map01100 H thiamine COG1564 Cluster_241155 V1217885 S Protein of unknown function (DUF418) 0YAB0 Cluster_300826 V1217887 HISN map00340,map00521,map00562,map01100,map01110,map01230,map04070 E histidinol-phosphate phosphatase COG0483 Cluster_419713 V1217888 SUHB G inositol mono-phosphatase COG0483 Cluster_157814 V1217889 IADA S Isoaspartyl dipeptidase 0XNTK Cluster_287329 V1217890 M (sortase) family COG3764 Cluster_74183 V1217892 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_492117 V1217893 S septicolysin 11TVT Cluster_265674 V1217894 DINB L Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) COG0389 Cluster_371948 V1217895 MAA S maltose O-acetyltransferase COG0110 Cluster_220808 V1217896 ANSA map00250,map00460,map00910,map01100,map01110 E L-asparaginase COG0252 Cluster_329085 V1217897 S secreted protein 0Y4BT Cluster_277700 V1217898 S NA 129E3 Cluster_560740 V1217899 LSPA map03060 M, U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) COG0597 Cluster_378825 V1217900 S Membrane 129XD Cluster_298176 V1217901 TRPC map00400,map01100,map01110,map01230 E Indole-3-glycerol phosphate synthase COG0134 Cluster_145714 V1217902 TRPB map00260,map00400,map01100,map01110,map01230 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) COG0133 Cluster_310721 V1217903 TRPA map00260,map00400,map01100,map01110,map01230 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) COG0159 Cluster_699177 V1217904 LGT M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 Cluster_233692 V1217906 YEDI S Inner membrane protein yedI COG2354 Cluster_231264 V1217907 GUAB1 map00230,map00983,map01100,map01110 F Dehydrogenase COG0517 Cluster_396549 V1217908 RPFA S Resuscitation-promoting factor 11WB2 Cluster_21686 V1217909 MT0885 S NA 0XPFG Cluster_277701 V1217910 ERCC3 map03022,map03420 L helicase COG1061 Cluster_61557 V1217911 PBP2B M penicillin-binding protein COG0768 Cluster_94688 V1217912 COBQ map00860,map01100 H catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) COG1492 Cluster_256435 V1217913 MTR map00010,map00020,map00260,map00280,map00480,map00620,map01100,map01110,map01120 C pyridine nucleotide-disulfide oxidoreductase COG1249 Cluster_313740 V1217914 S NA 0Y8QF Cluster_339549 V1217915 S Multi-copper polyphenol oxidoreductase laccase COG1496 Cluster_180322 V1217916 S repeat protein 11IAG Cluster_182984 V1217917 MT0238 map00350,map00362,map00627,map00642,map00903,map01120 I Acyl-transferase COG1835 Cluster_10628 V1217918 AFTD S coagulation factor 5 8 type domain-containing protein 0YR9E Cluster_352055 V1217919 T Response Regulator COG0745 Cluster_417943 V1217920 PPIB O PPIases accelerate the folding of proteins COG0652 Cluster_389410 V1217921 TDK map00240,map00983,map01100 F thymidine kinase COG1435 Cluster_497105 V1217922 LUXS map00270,map05111 T Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) COG1854 Cluster_182083 V1217923 MRDB M Rod shape-determining protein rodA COG0772 Cluster_285920 V1217924 NFO map03410 L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) COG0648 Cluster_124748 V1217926 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_339550 V1217927 YFIH S Multi-copper polyphenol oxidoreductase laccase COG1496 Cluster_210470 V1217928 D DivIVA protein COG3599 Cluster_288682 V1217929 OCAR_5968 S Protein of unknown function (DUF1009) COG3494 Cluster_103423 V1217931 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_141264 V1217932 S UPF0597 protein COG3681 Cluster_741427 V1217933 MUG map03410 L U mismatch-specific DNA glycosylase COG3663 Cluster_408817 V1217934 PDUO map00860,map01100 S adenosyltransferase COG2096 Cluster_769953 V1217935 O ADP-ribosylation crystallin J1 COG1397 Cluster_77815 V1217936 P Sodium hydrogen exchanger COG4651 Cluster_209399 V1217937 S Ankyrin repeat protein COG0666 Cluster_117712 V1217938 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_61271 V1217940 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_71233 V1217941 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0847 Cluster_387710 V1217942 TREY map00500,map01100,map01110 G malto-oligosyltrehalose synthase COG3280 Cluster_19107 V1217943 RV3401 map00500,map01100 G hydrolase family 65, central catalytic COG1554 Cluster_194418 V1217944 SDHA map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020,map05134 C succinate dehydrogenase, flavoprotein subunit COG1053 Cluster_534405 V1217945 AROQ map00400,map01051,map01100,map01110,map01230 E Catalyzes a trans-dehydration via an enolate intermediate (By similarity) COG0757 Cluster_152047 V1217946 map00400,map01100,map01110,map01230 E shikimate COG0703 Cluster_185559 V1217947 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_156103 V1217948 AROA map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate synthase COG0128 Cluster_2616 V1217949 M domain protein COG4932 Cluster_79789 V1217950 OCAR_6158 L Terminase, large subunit COG4626 Cluster_820698 V1217951 ELI_1297 O phage portal protein HK97 family COG4695 Cluster_326024 V1217952 S Rhodanese-like domain 11QSF Cluster_91862 V1217953 map00680,map01120 S Phosphotransferase 0Y7VB Cluster_236087 V1217954 C iron-sulfur 11G02 Cluster_310722 V1217955 RSME S Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) COG1385 Cluster_205044 V1217956 PHOH T Phoh family COG1702 Cluster_231265 V1217957 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_425159 V1217960 S NA 0Z4GX Cluster_37490 V1217961 M Transglycosylase SLT domain COG0739 Cluster_175332 V1217962 S ATP GTP-binding protein 0XNYD Cluster_348936 V1217963 NUSB K Involved in the transcription termination process (By similarity) COG0781 Cluster_427091 V1217964 PYRR map00240,map01100 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) COG2065 Cluster_233693 V1217965 PYRB map00240,map00250,map01100 F aspartate transcarbamylase COG0540 Cluster_463025 V1217966 PYRC map00240,map01100 F dihydroorotase COG0044 Cluster_548991 V1217967 PROB map00330,map01100,map01230 E Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) COG0263 Cluster_344113 V1217968 SRTA M (sortase) family COG3764 Cluster_373566 V1217969 GPMB map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_266987 V1217970 PSTA map02010 P phosphate abc transporter COG0581 Cluster_324524 V1217971 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_375281 V1217972 PHOU P Plays a role in the regulation of phosphate uptake COG0704 Cluster_64841 V1217973 PHOR map02020 T Histidine kinase 0XNMH Cluster_102252 V1217974 HYDG map00730,map01100 H biosynthesis protein thiH COG1060 Cluster_162042 V1217975 HYDF S gtp-binding protein COG1160 Cluster_353719 V1217976 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_319902 V1217977 SP_1381 V abc transporter atp-binding protein COG1131 Cluster_200886 V1217978 S NA 0YEPS Cluster_79480 V1217979 PURF map00230,map00250,map01100,map01110 F glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_523148 V1217980 MT0828 S NA 11U2D Cluster_241156 V1217981 map00130,map00362,map01100,map01110,map01120 I thioesterase COG1607 Cluster_576409 V1217982 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_497106 V1217983 BL01774 map00053,map01100,map01120,map02060 G IIa component COG1762 Cluster_345743 V1217984 map00030,map01100,map01110,map01120,map01230 G Transaldolase COG0176 Cluster_405373 V1217985 V HsdM N-terminal domain COG0286 Cluster_167677 V1217987 YGFZ map00260,map00670,map00910,map01100 S Folate-binding protein YgfZ COG0354 Cluster_261671 V1217988 PABC map00280,map00290,map00770,map00790,map01100,map01110,map01210,map01230 E Aminotransferase COG0115 Cluster_361987 V1217989 I May play a role in the intracellular transport of hydrophobic ligands 11G4X Cluster_101138 V1217990 LEUC map00290,map00660,map01100,map01110,map01210,map01230 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) COG0065 Cluster_338116 V1217991 K HTH_ICLR COG1414 Cluster_247739 V1217992 BMUL_2943 G Major Facilitator Superfamily 0XNST Cluster_382325 V1217993 NNRE G Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity) COG0062 Cluster_224327 V1217994 DNAC L DNA replication protein COG1484 Cluster_382326 V1217995 OPUCD map02010 E Glycine betaine carnitine choline COG1174 Cluster_224328 V1217996 OPUCC map02010 M Glycine betaine COG1732 Cluster_33524 V1217997 UVRD map03420,map03430 L ATP-dependent DNA helicase pcra COG0210 Cluster_43132 V1217998 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_708447 V1217999 GATC map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0721 Cluster_257720 V1218001 S CAAX amino terminal protease family protein COG1266 Cluster_832236 V1218002 HSDM V type I restriction-modification system COG0286 Cluster_238605 V1218003 KDGT P The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) 0XNUJ Cluster_131893 V1218004 AMD E amidohydrolase COG1473 Cluster_456889 V1218005 S DNA-binding helix-turn-helix protein 11HJM Cluster_551892 V1218006 YPJC S YitT family COG1284 Cluster_699178 V1218007 HUP L DNA-binding protein COG0776 Cluster_228941 V1218008 PRSA O Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) COG0760 Cluster_22100 V1218009 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_193481 V1218010 NRDF map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_97881 V1218011 TET38 P MFS family major facilitator transporter, tetracycline cation symporter COG0477 Cluster_175333 V1218012 ACD map00071,map00280,map00281,map00362,map00410,map00640,map00650,map01100,map01110,map01120,map03320 I Acyl-CoA dehydrogenase, C-terminal domain COG1960 Cluster_540113 V1218013 ARGF map00330,map01100,map01110,map01230 E ornithine carbamoyltransferase COG0078 Cluster_449006 V1218014 CHLI map00860,map01100,map01110 H magnesium chelatase COG1240 Cluster_168527 V1218015 CHLI map00860,map01100,map01110 H magnesium chelatase COG1239 Cluster_89506 V1218016 MQO map00620 C malate dehydrogenase (quinone) COG0579 Cluster_200887 V1218017 I Alpha beta hydrolase fold COG2267 Cluster_751507 V1218018 S UPF0473 protein 0Z6ED Cluster_512449 V1218019 FUR P Ferric uptake COG0735 Cluster_68561 V1218020 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_632861 V1218021 S Protein of unknown function (DUF964) 102XZ Cluster_382327 V1218022 YRRM map00340,map00350,map00360,map00624,map00940,map00941,map00945,map01100,map01110,map01120 S O-methyltransferase COG4122 Cluster_148080 V1218023 YEGQ map05120 O Peptidase U32 COG0826 Cluster_193482 V1218024 E, G Membrane COG0697 Cluster_268386 V1218025 ASD map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) COG0136 Cluster_98435 V1218026 S Predicted membrane protein (DUF2157) 11HGJ Cluster_517819 V1218027 MUTB map00280,map00630,map00640,map00720,map01100,map01120 I Methylmalonyl-coA mutase COG2185 Cluster_49369 V1218028 MUTA map00280,map00630,map00640,map00720,map01100,map01120 I Methylmalonyl-coA mutase COG2185 Cluster_357084 V1218029 HFLC O SPFH domain, Band 7 family protein COG0330 Cluster_319903 V1218030 THYX map00240,map00340,map00350,map00624,map00670,map01120 F Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) COG1351 Cluster_454954 V1218031 S NA 0YF67 Cluster_460906 V1218032 MCSA S Uvrb UvrC protein COG3880 Cluster_223152 V1218033 MCSB map00330 E ATP guanido phosphotransferase COG3869 Cluster_23124 V1218034 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_60652 V1218035 V ABC superfamily ATP binding cassette transporter, ABC membrane protein COG1132 Cluster_35995 V1218036 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_104595 V1218037 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_276393 V1218039 M (sortase) family COG3764 Cluster_283107 V1218040 SRTC M (sortase) family COG3764 Cluster_271048 V1218041 SRTB M (sortase) family COG3764 Cluster_189882 V1218044 S Triacylglycerol lipase COG1075 Cluster_68218 V1218045 NNR G carbohydrate kinase, YjeF related protein COG0063 Cluster_74484 V1218046 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0802 Cluster_292649 V1218047 P ABC 3 transport family protein 128A2 Cluster_185560 V1218048 MNTA map02010 P periplasmic solute binding protein COG0803 Cluster_177783 V1218049 BMPA S basic membrane COG1744 Cluster_836123 V1218050 YFGQ P Cation-transporting atpase COG0474 Cluster_378826 V1218051 DEOC map00030 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) COG0274 Cluster_305168 V1218052 HISK map00340,map01100,map01110,map01230 E histidinol phosphate phosphatase hisj family COG1387 Cluster_238606 V1218053 GYAR map00260,map00630,map00680,map01100,map01120,map01230 C 2-hydroxyacid dehydrogenase COG1052 Cluster_131122 V1218054 WBLL S NA 0XWNY Cluster_176951 V1218055 TELA P Resistance protein COG3853 Cluster_94689 V1218056 S NA 0XWFB Cluster_310723 V1218059 COMEA L Competence protein COG1555 Cluster_58278 V1218060 COMEC S ComEC Rec2-like protein COG0658 Cluster_73855 V1218061 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_151215 V1218062 S SAM-dependent methyltransferase COG1092 Cluster_283108 V1218063 L nudix hydrolase COG0494 Cluster_40709 V1218064 GLGE map00500,map01100,map04973 G Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) COG0366 Cluster_196963 V1218065 MT3314 I diacylglycerol kinase, catalytic region COG1597 Cluster_122153 V1218066 MT3308 S secreted protein 0XRRW Cluster_233694 V1218067 PRMA J Methylates ribosomal protein L11 (By similarity) COG2264 Cluster_211610 V1218068 DGT map00230 F deoxyguanosinetriphosphate triphosphohydrolase-like protein COG0232 Cluster_738003 V1218069 RPSQ map03010 J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal COG0186 Cluster_134265 V1218070 S NA 0ZCNR Cluster_291291 V1218071 RLUD J pseudouridine synthase COG0564 Cluster_291292 V1218072 PPNK map00760,map01100 G Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) COG0061 Cluster_692088 V1218073 KDPC map02020 P One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) COG2156 Cluster_36548 V1218074 KDPB map02020 P One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) COG2216 Cluster_70236 V1218075 KDPA map02020 P One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) COG2060 Cluster_62371 V1218077 V ABC transporter COG1132 Cluster_582753 V1218082 TRPE map00400,map01100,map01110,map01230 E anthranilate synthase component i COG0147 Cluster_312250 V1218083 HISF map00340,map01100,map01110,map01230 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) COG0107 Cluster_287330 V1218084 IMPA map00521,map00562,map01100,map01110,map04070 G inositol mono-phosphatase COG0483 Cluster_333539 V1218085 HISA map00340,map00400,map01100,map01110,map01230 E Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase COG0106 Cluster_463026 V1218086 J ribosome-associated inhibitor protein Y COG1544 Cluster_36684 V1218087 S Transglycosylase SLT domain COG3953 Cluster_233695 V1218090 MT4035 S NA 0XR0D Cluster_255206 V1218091 HUNADC P transporter COG0471 Cluster_80970 V1218092 RPOD K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_589245 V1218093 S RteC protein 10SVC Cluster_114877 V1218094 V MatE COG0534 Cluster_279061 V1218095 K Transcriptional regulator, ARAC family COG2207 Cluster_523149 V1218096 S NA 11NIN Cluster_35569 V1218097 FEOB P Ferrous iron transport protein b COG0370 Cluster_751508 V1218098 FEOA P Ferrous iron transport protein A COG1918 Cluster_773618 V1218099 P domain protein 101JI Cluster_261672 V1218100 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_800884 V1218101 LKTB3 V ABC transporter, ATP-binding protein COG2274 Cluster_220809 V1218102 S Protein of unknown function (DUF2984) 0Z0TY Cluster_44286 V1218103 NRDF map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_744740 V1218106 PFLAC C Formate acetyltransferase COG1882 Cluster_545936 V1218108 S NA 0YDRM Cluster_683120 V1218109 S NA 0YPRS Cluster_33637 V1218110 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_61272 V1218111 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 Cluster_238607 V1218112 HMUT map02010 P Periplasmic binding protein COG4558 Cluster_189019 V1218113 HMUU map02010 P transport system permease protein COG0609 Cluster_289979 V1218114 HMUV map02010 P Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) COG4559 Cluster_358754 V1218115 HMUO map00860,map04978 P Heme oxygenase COG5398 Cluster_284483 V1218117 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120 G phosphohexose isomerase COG0166 Cluster_89972 V1218118 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_3423 V1218119 U, W Inherit from COG: domain protein COG5295 Cluster_403565 V1218120 THIM map00730,map01100 H 4-methyl-5-beta-hydroxyethylthiazole kinase COG2145 Cluster_442961 V1218121 THIW S thiw protein COG4732 Cluster_54027 V1218122 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_155292 V1218123 S NA 125RX Cluster_257721 V1218124 K cell envelope-related transcriptional attenuator COG1316 Cluster_280365 V1218125 S Membrane COG1434 Cluster_298177 V1218126 map02010 P cobalt transport COG0619 Cluster_38493 V1218127 S NA 121Q8 Cluster_224329 V1218128 S NA 126B8 Cluster_237292 V1218129 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_49370 V1218130 MUTL map03430 L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) COG0323 Cluster_95204 V1218131 M Cell wall anchor domain protein 11PS2 Cluster_205045 V1218132 DMPA E, Q peptidase s58 dmpa COG3191 Cluster_124094 V1218133 GLTT C -dicarboxylate symporter COG1301 Cluster_18860 V1218134 map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_465113 V1218135 YMDB S appr-1-p processing domain protein COG2110 Cluster_625314 V1218136 S NA 0XX7Y Cluster_241157 V1218137 RBSC-2 S abc transporter, permease COG1079 Cluster_182985 V1218138 RBSC-1 S ABC transporter (Permease) COG4603 Cluster_67523 V1218139 PPAC map00190 C Manganese-dependent inorganic pyrophosphatase COG1227 Cluster_246479 V1218141 WBBL M Glycosyl transferase, family 2 COG1216 Cluster_225505 V1218142 RFBD map00521,map00523,map01100,map01110 M Dtdp-4-dehydrorhamnose reductase COG1091 Cluster_219622 V1218143 LYTR1 K TRANSCRIPTIONal COG1316 Cluster_59589 V1218144 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_327590 V1218145 SCLAV_1530 S UPF0246 protein COG3022 Cluster_185561 V1218146 CYSG map00860,map01100,map01110 H Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) COG0007 Cluster_171148 V1218147 G abc transporter integral membrane protein COG1172 Cluster_373567 V1218150 SP_0899 S Membrane Associated 114SZ Cluster_197893 V1218151 MVAK2 map00900,map01100,map01110 I Phosphomevalonate kinase COG1577 Cluster_157815 V1218152 MVAS map00072,map00280,map00650,map00900,map01100,map01110 I Hydroxymethylglutaryl-CoA synthase COG3425 Cluster_171967 V1218154 GLGC map00500,map00520,map01100,map01110 G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) COG0448 Cluster_179500 V1218155 GLGD map00500,map00520,map01100,map01110 M glucose-1-phosphate adenylyltransferase, glgd subunit COG0448 Cluster_101698 V1218156 GLGA map00500,map01100,map01110,map04973 G Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) COG0297 Cluster_105189 V1218158 NORM V Mate efflux family protein COG0534 Cluster_163681 V1218162 S NA 0Z2CV Cluster_534406 V1218166 S Protein of unknown function (DUF1049) 12CJV Cluster_300827 V1218167 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_288683 V1218168 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_430958 V1218169 RPSB map03010 J 30S ribosomal protein S2 COG0052 Cluster_8005 V1218170 PYC map00020,map00620,map00720,map01100,map01120,map01230 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) COG1038 Cluster_177784 V1218171 S gtp-binding protein COG3596 Cluster_436939 V1218173 FOLE map00790,map01100 H GTP cyclohydrolase i COG0302 Cluster_489619 V1218174 S domain protein COG1418 Cluster_766218 V1218177 YVLC S phage shock protein C, PspC COG1983 Cluster_119125 V1218180 L transposase, IS605 OrfB COG0675 Cluster_644780 V1218181 L transposase COG1943 Cluster_450979 V1218183 COAD map00770,map01100 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) COG0669 Cluster_329086 V1218184 S Phage replisome organizer 0ZW0Q Cluster_250306 V1218185 SCLAV_3818 map00010,map00040,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00640,map00903,map01100,map01110,map01120 C Aldehyde dehydrogenase COG1012 Cluster_33244 V1218186 BETT P Transporter COG1292 Cluster_352056 V1218187 GLUB map02010,map02020 E, T Extracellular solute-binding protein family 3 COG0834 Cluster_358755 V1218188 GLUC map02010 E ABC transporter COG0765 Cluster_232425 V1218189 GLUD map02010 E amino acid AbC transporter COG0765 Cluster_465114 V1218190 C flavodoxin family COG0716 Cluster_157816 V1218193 YTFP S hi0933 family COG2081 Cluster_347319 V1218194 RLUB J Pseudouridine synthase COG1187 Cluster_18674 V1218197 S NA 10111 Cluster_365299 V1218198 STP T phosphatase COG0631 Cluster_109426 V1218199 MIAB J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) COG0621 Cluster_213816 V1218200 LACC map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G tagatose-6-phosphate kinase COG1105 Cluster_74814 V1218201 S fad dependent oxidoreductase COG2509 Cluster_316853 V1218202 TATD L Hydrolase, tatD family COG0084 Cluster_456891 V1218203 RNMV L Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) COG1658 Cluster_277702 V1218204 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_48959 V1218205 M Putative cell wall binding repeat 2 COG2247 Cluster_863863 V1218206 SCFA S RSAM-modified six-cysteine peptide 0XUIZ Cluster_57023 V1218207 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 Cluster_198888 V1218208 REP L Replication Protein COG5527 Cluster_74485 V1218209 S relaxase Mobilization nuclease 17A1X@proNOG Cluster_196964 V1218212 YCIC S cobalamin synthesis protein P47K COG0523 Cluster_88571 V1218213 CAT1 map00281,map00620,map00626,map01110,map01120 C Transferase COG0427 Cluster_91863 V1218214 SERA map00260,map00270,map00680,map01100,map01120,map01230 E d-3-phosphoglycerate dehydrogenase COG0111 Cluster_234892 V1218215 TRXB map00240,map00450 O thioredoxin reductase COG0492 Cluster_231266 V1218217 I Diacylglycerol kinase COG1597 Cluster_50159 V1218218 NDVA V ABC superfamily ATP binding cassette transporter COG1132 Cluster_438972 V1218219 MAK map00500,map01100 G Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) COG3281 Cluster_365300 V1218220 K Transcriptional regulator, TetR family 11IM0 Cluster_375282 V1218221 LOLD V abc transporter atp-binding protein COG1136 Cluster_176952 V1218222 APBE H ApbE family COG1477 Cluster_467194 V1218223 S NA 0YPTE Cluster_268387 V1218225 COBS map00860,map01100 H Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) COG0368 Cluster_36869 V1218226 YWMD S von Willebrand factor, type A COG2304 Cluster_83006 V1218227 GLTD map00250,map00910,map01100,map01110,map01120,map01230 E Glutamate synthase COG0493 Cluster_21001 V1218228 GLTB map00250,map00630,map00910,map01100,map01110,map01120,map01230 E Glutamate synthase COG0070 Cluster_705344 V1218229 PTSH G phosphocarrier protein (HPr COG1925 Cluster_396550 V1218230 PPIB O PPIases accelerate the folding of proteins COG0652 Cluster_253997 V1218231 map00190,map00680,map01100 C ATP synthase alpha/beta chain, C terminal domain COG1155 Cluster_563696 V1218232 GLOA map00620,map04011 E Lactoylglutathione lyase COG0346 Cluster_403566 V1218233 PTH J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) COG0193 Cluster_629038 V1218234 S Phospholipase, patatin family 0YEF4 Cluster_285921 V1218235 S Phospholipase, patatin family 0YEF4 Cluster_477936 V1218236 S NA 11XBE Cluster_57271 V1218237 MDLA V ABC transporter COG1132 Cluster_330483 V1218238 MUTE map02010 S ABC transporter, permease 11NSJ Cluster_373568 V1218239 SPAR T response regulator COG0745 Cluster_741428 V1218240 T His Kinase A (phospho-acceptor) domain COG2205 Cluster_515152 V1218241 F nudix hydrolase COG1051 Cluster_367004 V1218251 SCLAV_0739 map00620 S Beta-lactamase domain protein 10GCR Cluster_268388 V1218252 PPIB O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) COG0652 Cluster_36397 V1218253 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_446983 V1218254 YHCG S Conserved Protein COG4804 Cluster_167678 V1218255 THIH map00730,map01100 H biosynthesis protein thiH COG1060 Cluster_318424 V1218256 THIG map00730,map01100 H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) COG2022 Cluster_410677 V1218257 THIF map00730,map01100,map04122 H Thiamine biosynthesis protein ThiF COG0476 Cluster_224330 V1218259 MVAD map00900,map01100,map01110 I diphosphomevalonate decarboxylase COG3407 Cluster_201879 V1218260 MVK map00900,map01100,map01110,map04146 I mevalonate kinase COG1577 Cluster_119126 V1218261 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_617864 V1218262 ILVB map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E acetolactate synthase COG0028 Cluster_471482 V1218263 ILVN map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E Acetolactate synthase small subunit COG0440 Cluster_98436 V1218264 P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) COG0168 Cluster_83007 V1218265 S ABC transporter COG0488 Cluster_231267 V1218266 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G phosphohexokinase COG0205 Cluster_417944 V1218267 S (sortase) family 11V31 Cluster_273709 V1218268 S AP2 domain 123DH Cluster_281709 V1218270 ETFB map00910 C Electron transfer flavoprotein COG2086 Cluster_177785 V1218271 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_246480 V1218272 PRMA J Methylates ribosomal protein L11 (By similarity) COG2264 Cluster_338117 V1218273 RSME S Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) COG1385 Cluster_312251 V1218276 D replication-associated protein COG1192 Cluster_96290 V1218280 YLOV S dak2 domain fusion protein ylov COG1461 Cluster_232426 V1218281 THIL map00730,map01100 H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) COG0611 Cluster_387711 V1218285 S Carbohydrate binding domain 1227X Cluster_333540 V1218287 M Bacteriophage peptidoglycan hydrolase COG0791 Cluster_617865 V1218289 S Toxin-antitoxin system, antitoxin component, HicB family 11KI8 Cluster_206120 V1218293 S Protein of unknown function (DUF3644) 11F6J Cluster_172875 V1218294 M group 1 glycosyl transferase COG0438 Cluster_242528 V1218295 DUSB J Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_306557 V1218296 COAX map00770,map01100 K Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) COG1521 Cluster_434888 V1218297 MT3354 S NA 11P0K Cluster_110742 V1218298 MANB map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G phosphomannomutase COG1109 Cluster_554753 V1218299 MT3357 S Possibl zinc metallo-peptidase 11VPR Cluster_285922 V1218301 GLPF G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) COG0580 Cluster_199884 V1218302 S filamentation induced by cAMP protein Fic COG3177 Cluster_135064 V1218303 T Histidine kinase COG0642 Cluster_357085 V1218304 T response regulator COG0745 Cluster_148081 V1218305 SCLAV_0509 S Cytochrome c oxidase caa3-type, assembly factor ctag-related protein COG3336 Cluster_68219 V1218307 YJJK S ABC transporter, ATP-binding protein COG0488 Cluster_380555 V1218308 TMK map00240,map01100 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) COG0125 Cluster_67889 V1218309 MTRB map02020 T Histidine kinase 0XNMH Cluster_554754 V1218311 S Toxin-antitoxin system, toxin component 0XRRU Cluster_242529 V1218312 MUTY map03410 L a g-specific adenine glycosylase COG1194 Cluster_414360 V1218313 CYNT map00910 P carbonic anhydrase COG0288 Cluster_116995 V1218314 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_322950 V1218315 CG1711 C Aldo keto reductase COG0667 Cluster_190745 V1218316 LPPL S prolipoprotein LppL 0Z2Q4 Cluster_182986 V1218317 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) COG0167 Cluster_112037 V1218318 ISOVA_0221 V HNH endonuclease 11RVB Cluster_179501 V1218319 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_352057 V1218320 CBIQ map02010 P Cobalt abc transporter COG0619 Cluster_303660 V1218321 CBIM map02010 P Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) COG0310 Cluster_242530 V1218322 CYSK map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_566890 V1218323 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_554755 V1218324 S NA 0ZJ2P Cluster_458858 V1218326 S Nitroreductase 1234Z Cluster_221972 V1218327 DUSB J Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_20847 V1218328 L dEAD DEAH box helicase COG1204 Cluster_512450 V1218330 S Gcn5-related n-acetyltransferase 17QRN@proNOG Cluster_392955 V1218332 LEXA K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) COG1974 Cluster_178624 V1218336 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_288684 V1218338 PANB map00770,map01100,map01110 H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) COG0413 Cluster_61273 V1218339 SCLAV_1772 S chad domain containing protein 0YY54 Cluster_773619 V1218340 SCLAV_1493 S NA 0XUCQ Cluster_452928 V1218342 SECF map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) COG0341 Cluster_47111 V1218343 SECD map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) COG0342 Cluster_330484 V1218344 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_303661 V1218346 OCAR_4090 map00240,map00380,map00410,map00460,map00627,map00643,map00770,map00910,map00983,map01100,map01120 S nitrilase cyanide hydratase and apolipoprotein n-acyltransferase COG0388 Cluster_384101 V1218347 SDPI S Membrane COG5658 Cluster_809129 V1218348 YVBA K Transcriptional regulator, arsr family COG0640 Cluster_326026 V1218349 K transcriptional regulator, IclR family COG1414 Cluster_162043 V1218350 PGN_0971 L Transposase, is4 family COG3039 Cluster_37645 V1218352 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_307864 V1218353 S NA 1119B Cluster_51922 V1218354 S NA 1217B Cluster_512451 V1218356 S NA 0Y5YG Cluster_150448 V1218358 S NA 0XW3Z Cluster_50762 V1218359 ASA S Ceramidase 0XQWE Cluster_336573 V1218361 FABG map00061,map00780,map01040,map01100 I reductase 0XNW1 Cluster_39476 V1218362 GLNN map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG3968 Cluster_714956 V1218363 RPSK map03010 J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) COG0100 Cluster_206121 V1218364 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_540114 V1218365 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_69937 V1218366 M Putative cell wall binding repeat 2 COG2247 Cluster_43133 V1218368 YYBT T domain protein COG3887 Cluster_144968 V1218370 GLYA map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01230 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) COG0112 Cluster_156949 V1218371 SUCB map00010,map00020,map00280,map00310,map00620,map01100,map01110,map01120 C 2-oxoglutarate dehydrogenase E2 component, dihydrolipoamide succinyltransferase COG0508 Cluster_83393 V1218372 PEPA map00480,map01100 E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) COG0260 Cluster_277703 V1218373 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E brancheD-chain amino acid aminotransferase COG0115 Cluster_50359 V1218374 GLGB map00500,map01100,map01110 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) COG0296 Cluster_212694 V1218375 IOLG2 map00521,map00562,map01100,map01110,map01120 Q Myo-inositol 2-dehydrogenase COG0673 Cluster_548992 V1218376 NUSB K Involved in the transcription termination process (By similarity) COG0781 Cluster_172876 V1218377 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_330485 V1218378 GUAB3 map00230,map00983,map01100,map01110 F Dehydrogenase COG0516 Cluster_80581 V1218379 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_540115 V1218380 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_225506 V1218381 map00010,map01110,map01120 G aldose 1-epimerase COG2017 Cluster_53277 V1218382 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_309281 V1218383 MRP D ATP-binding protein COG0489 Cluster_247740 V1218384 S phage protein 0XQDU Cluster_492118 V1218385 S Alanine rich transmembrane protein 11W3D Cluster_310724 V1218386 MT2770 S Protein of unknown function (DUF3710) 11Q1S Cluster_145715 V1218387 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_55496 V1218388 PULA G Glycogen debranching enzyme COG1523 Cluster_51324 V1218389 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_264347 V1218390 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_330486 V1218396 FETB map02010 P Periplasmic binding protein COG4607 Cluster_199885 V1218397 FATC map02010 P permease protein COG4605 Cluster_321385 V1218398 FEUA map02010 P abc transporter atp-binding protein COG4604 Cluster_617866 V1218399 RNHA map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0328 Cluster_319904 V1218402 S Pfam:DUF124 COG2013 Cluster_9733 V1218404 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_793003 V1218405 MODE H TOBE domain protein COG3585 Cluster_12712 V1218406 GLNE O, T Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) COG1391 Cluster_296776 V1218410 map00561,map01100 S Secretory lipase 0YTM1 Cluster_440947 V1218411 ECFT map02010 P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) COG0619 Cluster_298178 V1218412 ZURM map02010 P ABC, transporter COG1108 Cluster_370329 V1218413 ADCC map02010 P ABC transporter COG1121 Cluster_191664 V1218414 ZNUA map02010 P periplasmic solute binding protein COG0803 Cluster_428988 V1218415 S NA 0XU7T Cluster_617868 V1218416 L UPF0102 protein COG0792 Cluster_292650 V1218417 YQFL S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) COG1806 Cluster_18675 V1218418 PPDK map00620,map00680,map00710,map00720,map01100,map01120 G Pyruvate phosphate dikinase COG0574 Cluster_477937 V1218419 RUVC map03440 L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) COG0817 Cluster_332049 V1218420 FABG map00061,map00780,map01040,map01100 S reductase 0XNW1 Cluster_341003 V1218421 T Two component transcriptional regulator, winged helix family COG0745 Cluster_117713 V1218422 map02020 T Histidine kinase COG0642 Cluster_781086 V1218424 RPOZ map00230,map00240,map01100,map03020 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) COG1758 Cluster_164489 V1218425 COABC map00770,map01100 H Phosphopantothenoylcysteine decarboxylase COG0452 Cluster_458859 V1218426 AHCY map00270,map01100 H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) COG0499 Cluster_169459 V1218427 MANA map00051,map00520,map01100,map01110 G mannose-6-phosphate isomerase COG1482 Cluster_61811 V1218429 map02010 V abc transporter COG1132 Cluster_438973 V1218430 map00790,map01100 H Pterin binding enzyme COG0294 Cluster_847968 V1218431 S Protein of unknown function (DUF3117) 121WY Cluster_262963 V1218432 RRMA Q Methyltransferase COG0500 Cluster_360422 V1218433 BUDA map00650,map00660 Q Alpha-acetolactate decarboxylase COG3527 Cluster_295433 V1218434 G Inherit from NOG: Cellulase (glycosyl hydrolase family 5) 0ZVSV Cluster_19205 V1218435 L Inherit from COG: helicase 0XPYJ Cluster_446984 V1218436 FTHC map00670,map01100 H 5-formyltetrahydrofolate cyclo-ligase COG0212 Cluster_218460 V1218437 map00330,map01110,map01230 E Ornithine cyclodeaminase 10EHU Cluster_227759 V1218438 S oxygenase 0YDQ0 Cluster_84283 V1218439 STSA S Extracellular solute-binding protein, family 5 0XQUV Cluster_220810 V1218440 S cAMP factor 0YS1B Cluster_63746 V1218441 S CAMP factor (Cfa) 0Z1YX Cluster_246481 V1218442 G Ig domain protein, group 2 domain protein COG5492 Cluster_47288 V1218443 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_205046 V1218444 S NA 0YXS4 Cluster_273710 V1218445 map02010 V ABC transporter 0XPIZ Cluster_53278 V1218446 map02010 V ABC transporter 0XPIZ Cluster_164490 V1218447 BL01323 M Cell wall binding repeat 2-containing protein 0ZKZU Cluster_245157 V1218448 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_81342 V1218449 CAS3 L CRISPR-Associated Helicase Cas3 COG1203 Cluster_396552 V1218450 BION map02010 P Cobalt transport protein COG0619 Cluster_288685 V1218451 K, T Phage shock protein A COG1842 Cluster_209400 V1218452 CYDB map00190,map01100,map02020 C cytochrome d ubiquinol oxidase, subunit ii COG1294 Cluster_410678 V1218453 CYDD map02010 V ABC, transporter COG4988 Cluster_674146 V1218455 TRXA O Thioredoxin COG0526 Cluster_648834 V1218456 S NA 0ZJ2P Cluster_38314 V1218457 CTPC map00190 P heavy metal translocating P-type ATPase COG2217 Cluster_370330 V1218458 G isomerase COG0698 Cluster_399998 V1218459 LEPB map03060 U Signal peptidase i COG0681 Cluster_260345 V1218460 RNHC map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG1039 Cluster_678595 V1218461 S Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) 0XUW5 Cluster_440948 V1218462 CVPA S cvpA family COG1286 Cluster_560741 V1218463 RPSK map03010 J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) COG0100 Cluster_300828 V1218464 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_569971 V1218466 ADK map00230,map00240,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_17010 V1218467 S NA 0YAQZ Cluster_291293 V1218468 GDHA map00250,map00330,map00910,map01100 E Glutamate dehydrogenase COG0334 Cluster_319905 V1218469 S membrane 11VWI Cluster_223153 V1218470 SSCG_01435 E ABC transporter COG0765 Cluster_408819 V1218471 K Transcriptional regulator 11NA6 Cluster_306558 V1218472 SCLAV_0396 V ABC transporter COG1132 Cluster_125410 V1218473 RIMO J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) COG0621 Cluster_142768 V1218474 HFLX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COG2262 Cluster_38991 V1218475 map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_299461 V1218479 S NA 11H5V Cluster_29895 V1218480 PEPN map00480,map01100 E aminopeptidase N COG0308 Cluster_257722 V1218482 M (sortase) family COG3764 Cluster_57024 V1218483 M Cell wall anchor domain protein 129AF Cluster_384102 V1218485 CLOSA_0730 V Hnh endonuclease COG1479 Cluster_155293 V1218487 ECORIM L Modification methylase EcoRI 17X1E@proNOG Cluster_5789 V1218490 S NA 0YCCW Cluster_520373 V1218494 COMEB map00240,map01100 F deaminase COG2131 Cluster_377052 V1218495 CG2401 M Secreted protein COG0791 Cluster_70539 V1218502 S NA 0ZWV4 Cluster_487260 V1218503 S BioX protein 11WNI Cluster_353720 V1218504 BIOW map00780,map01100 H Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) COG1424 Cluster_223154 V1218505 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii subunits gamma and tau COG2812 Cluster_115560 V1218507 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_238608 V1218508 CTAB map00190,map00860,map01100,map01110 O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) COG0109 Cluster_355394 V1218509 CTAA map00190,map00860,map01100,map01110,map02020 O cytochrome oxidase assembly COG1612 Cluster_534407 V1218510 BL01497 Q methyltransferase COG0500 Cluster_80582 V1218511 MMDA map00280,map00630,map00640,map00720,map01100,map01120 I Methylmalonyl-CoA carboxyltransferase 12S subunit COG4799 Cluster_102797 V1218512 OADA map00020,map00330,map00620,map00720,map01100,map01120,map01230 C Oxaloacetate decarboxylase COG5016 Cluster_683121 V1218513 SCLAV_4880 map00500,map01100,map01110 G Glycogen debranching enzyme COG1523 Cluster_31740 V1218514 S NA 11U17 Cluster_335044 V1218515 GLNQ map02010 E abc transporter atp-binding protein COG1126 Cluster_162044 V1218516 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_39799 V1218518 S NA 0YCC9 Cluster_207230 V1218520 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_335045 V1218521 S NA 122AV Cluster_551894 V1218522 S Toxin-antitoxin system, antitoxin component, HicB family 12518 Cluster_176953 V1218523 EMBC M Arabinosyltransferase 0XSQE Cluster_41218 V1218524 AFTA M Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases 0Z57H Cluster_206122 V1218525 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_324525 V1218526 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_83008 V1218527 PPC map00620,map00680,map00710,map00720,map01100,map01120 C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) COG2352 Cluster_28153 V1218528 CAFA map03018 J ribonuclease COG1530 Cluster_674147 V1218529 RPLU map03010 J This protein binds to 23S rRNA in the presence of protein L20 (By similarity) COG0261 Cluster_734676 V1218530 RPMA map03010 J 50S ribosomal protein l27 COG0211 Cluster_119890 V1218532 S NA 0ZTYV Cluster_139780 V1218535 HTRA map03010 M peptidase S1 and S6, chymotrypsin Hap COG0265 Cluster_285923 V1218536 YOCS S Bile acid COG0385 Cluster_35430 V1218537 DEAD map03018 L RNA helicase COG0513 Cluster_79790 V1218538 S NA 0Y3S5 Cluster_124749 V1218539 P NMT1/THI5 like COG0715 Cluster_523150 V1218540 ZNTR K Transcriptional regulator COG0789 Cluster_471483 V1218541 S NA 1296H Cluster_187318 V1218542 PERMEASE S permease COG0701 Cluster_223155 V1218543 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit epsilon COG0847 Cluster_153652 V1218544 MURE map00300,map00550 M mur ligase COG0769 Cluster_319906 V1218545 COBQ S Glutamine amidotransferase COG3442 Cluster_419714 V1218547 map02010 P ATP-binding protein COG1120 Cluster_192596 V1218548 map02010 P Periplasmic binding protein COG0614 Cluster_391143 V1218549 S Membrane COG3949 Cluster_61274 V1218550 PTSG map00010,map00500,map00520,map02060 G PTS system COG2190 Cluster_133479 V1218551 BGLG K antiterminator COG3711 Cluster_531623 V1218552 PTSI map02060 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) COG1080 Cluster_361988 V1218553 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_265675 V1218554 YQFU S YitT family COG1284 Cluster_896283 V1218555 map00630,map01100 G Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) COG3622 Cluster_104596 V1218556 S AIPR protein 0ZFWF Cluster_405374 V1218557 K Pfam:DUF2174 COG4832 Cluster_176128 V1218558 S regulatory protein COG3641 Cluster_361989 V1218559 FHUC map02010 P ABC transporter COG1121 Cluster_268389 V1218560 map02010 P ABC transporter COG1108 Cluster_347320 V1218561 S Membrane COG3503 Cluster_275063 V1218562 YGCG S of methanol dehydrogenase type COG1512 Cluster_119891 V1218563 M Cell wall anchor domain protein 129AF Cluster_276394 V1218565 SRTB M (sortase) family COG3764 Cluster_216128 V1218566 GPSA map00564 C NADPH-dependent glycerol-3-phosphate dehydrogenase COG0240 Cluster_129612 V1218567 T Calcineurin-like phosphoesterase COG4639 Cluster_212695 V1218568 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_201880 V1218569 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_168528 V1218570 TGT J Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COG0343 Cluster_33389 V1218573 SCLAV_3021 S (twin-arginine translocation) pathway signal COG3211 Cluster_661272 V1218574 S NA 11W2C Cluster_48072 V1218576 FTSI map00550,map01100 M penicillin-binding protein COG0768 Cluster_517821 V1218577 S NA 11NZP Cluster_358756 V1218578 SSCG_03030 map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_161209 V1218579 V permease COG0577 Cluster_49580 V1218580 map00350,map00362,map00627,map00642,map00903,map01120 I acyltransferase 3 COG1835 Cluster_363556 V1218581 YEIH S Membrane COG2855 Cluster_218461 V1218582 S copper amine 0XP8R Cluster_134266 V1218583 METY map00270,map00450,map00920,map01100,map01110,map01230 E Cys/Met metabolism PLP-dependent enzyme COG2873 Cluster_189020 V1218585 LACI K laci family transcriptional regulator COG1609 Cluster_528835 V1218586 PSAA map02010 P ABC transporter COG0803 Cluster_582754 V1218587 S NA 12866 Cluster_512452 V1218589 RPIB map00030,map00710,map01100,map01110,map01120,map01230 G isomerase COG0698 Cluster_368619 V1218590 RND J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) COG0349 Cluster_436940 V1218591 SCLAV_4848 S Protein of unknown function (DUF3000) 11PF6 Cluster_288686 V1218592 HEMG map00860,map01100,map01110 H protoporphyrinogen oxidase COG1232 Cluster_227760 V1218594 DNAG map03030 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 Cluster_389411 V1218595 S Metallo-beta-lactamase superfamily COG0491 Cluster_163683 V1218596 ADHE2 map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map05204 C Dehydrogenase COG1062 Cluster_438974 V1218597 SP_1232 S Membrane COG4684 Cluster_256437 V1218598 SDAAA map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase COG1760 Cluster_86820 V1218599 VANW V VanW family COG2720 Cluster_174519 V1218601 S NA 0ZVJP Cluster_338119 V1218602 S NA 0Z20Q Cluster_531624 V1218603 S Phage major capsid protein COG4653 Cluster_285924 V1218604 CLPP map04112 O ATP-dependent Clp protease, proteolytic subunit COG0740 Cluster_160379 V1218605 O phage portal protein HK97 family COG4695 Cluster_252742 V1218606 OCAR_6158 L Terminase, large subunit COG4626 Cluster_101699 V1218607 S Copper amine oxidase domain-containing protein 0XT7E Cluster_299462 V1218608 S NA 0ZUR0 Cluster_108794 V1218610 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_287331 V1218611 S NA 11GJK Cluster_430959 V1218613 DNAQ2 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit epsilon COG0847 Cluster_175334 V1218614 ASPB E Aminotransferase COG0436 Cluster_164491 V1218615 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_296777 V1218616 MT0808 S Inherit from COG: deacetylase COG3233 Cluster_414361 V1218620 S RNA ligase 0Y4VX Cluster_399999 V1218622 RSMG M Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) COG0357 Cluster_502301 V1218623 TRMK S SAM-dependent methyltransferase COG2384 Cluster_57025 V1218624 DNAG map03030 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 Cluster_170322 V1218628 SURB S G5 domain protein 0ZVV3 Cluster_237293 V1218629 PSTS2 map02010,map02020,map05152 P Phosphate-binding protein COG0226 Cluster_122154 V1218630 map00051,map00363,map00520,map00591,map00625,map00650,map01100,map01120 M Dehydrogenase COG0677 Cluster_421510 V1218631 WBPD map00520 S Transferase hexapeptide repeat containing protein COG0110 Cluster_158690 V1218632 DEGT E DegT DnrJ EryC1 StrS aminotransferase COG0399 Cluster_387712 V1218634 CASE L crispr-associated protein 0XPHC Cluster_358757 V1218635 CAS5E L crispr-associated protein 11JEJ Cluster_176129 V1218636 CSE4 L Crispr-associated protein, cse4 family 0Y6PV Cluster_243880 V1218637 CASA L crispr-associated protein 0XPA1 Cluster_442962 V1218638 CTAE map00190,map00910,map01100 C oxidase (Subunit III) COG1845 Cluster_192597 V1218639 TRPD map00400,map01100,map01110,map01230 E anthranilate phosphoribosyltransferase COG0547 Cluster_7622 V1218640 S NA 0ZHVH Cluster_436941 V1218641 PEPS E aminopeptidase COG2309 Cluster_76096 V1218643 MEPA M peptidase COG0739 Cluster_419716 V1218644 S Allergen V5 TPX-1 0XUG5 Cluster_281710 V1218645 K transcriptional regulator, merr family COG0789 Cluster_232427 V1218646 L integrase family 0ZJHZ Cluster_99486 V1218647 L helicase COG4646 Cluster_54295 V1218650 S Oligopeptide transporter, Opt family COG1297 Cluster_625317 V1218651 S Coenzyme PQQ synthesis protein D (PqqD) 11PNC Cluster_777347 V1218652 C Anaerobic dehydrogenase COG0243 Cluster_683122 V1218653 E Branched-chain amino acid 0Y67M Cluster_347321 V1218654 AZLC E azlc family COG1296 Cluster_7979 V1218656 FAS map00061,map01100 I fatty acid synthase COG4982 Cluster_58279 V1218657 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_438975 V1218659 INFC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) COG0290 Cluster_813113 V1218660 RPMI map03010 J 50S ribosomal protein L35 COG0291 Cluster_287332 V1218661 TSNR J rrna methyltransferase COG0566 Cluster_294025 V1218662 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_141990 V1218663 BMUL_2277 L DNA Methylase COG1475 Cluster_824680 V1218664 S NA 0YY6Z Cluster_809130 V1218665 S NA 0XZ3Z Cluster_260346 V1218666 YHBJ S Displays ATPase and GTPase activities (By similarity) COG1660 Cluster_236088 V1218667 YBHK S UPF0052 protein COG0391 Cluster_502302 V1218668 T Two-component system sensor kinase COG4564 Cluster_122155 V1218669 G Major Facilitator Superfamily COG2807 Cluster_371949 V1218671 MT3543 S NA 11ISP Cluster_353721 V1218672 ISOVA_0221 V HNH endonuclease 11RVB Cluster_264349 V1218673 YTQA S Radical SAM Protein COG1242 Cluster_363557 V1218674 KTRA P domain protein COG0569 Cluster_335046 V1218675 SPOU J rrna methyltransferase COG0566 Cluster_207231 V1218676 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_245158 V1218677 PRKC T serine threonine protein kinase COG0515 Cluster_408820 V1218678 SUN J ribosomal RNA small subunit methyltransferase COG0144 Cluster_629040 V1218680 MAZF T Toxic component of a toxin-antitoxin (TA) module (By similarity) COG2337 Cluster_162045 V1218681 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_348938 V1218683 RPRY map02020 T response regulator COG0745 Cluster_126801 V1218684 CLCAR_1091 T Histidine kinase COG0642 Cluster_724877 V1218685 RHLE map03018 L atp-dependent rna helicase COG0513 Cluster_371950 V1218686 MURG map00550,map01100,map04112 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) COG0707 Cluster_89973 V1218687 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_174520 V1218688 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_288688 V1218689 PTS-EIID map00051,map00520,map01100,map02060 G PTS System COG3716 Cluster_259043 V1218690 PTS-EIIC map00051,map00520,map01100,map02060 G PTS System COG3715 Cluster_81750 V1218691 S integral membrane protein COG0628 Cluster_683123 V1218692 YQGV S Domain of unknown function DUF77 COG0011 Cluster_183803 V1218693 M Cell wall binding repeat 2-containing protein COG2247 Cluster_432969 V1218694 S Protein of unknown function (DUF523) COG5418 Cluster_271050 V1218695 S Inherit from NOG: Leucine rich repeat protein, bspa family protein 0Y4NF Cluster_463027 V1218696 S hemerythrin hhe cation binding domain protein COG3945 Cluster_499769 V1218697 SCLAV_3863 S Membrane 0XVS8 Cluster_276395 V1218698 MCA S mycothiol conjugate amidase mca COG2120 Cluster_189021 V1218699 AROF map00400,map01100,map01110,map01230 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) COG0722 Cluster_414362 V1218700 NTPE map00190,map00680,map01100 C subunit e 0Y7S3 Cluster_489620 V1218701 NTPK map00190,map00680,map01100 C V-type sodium ATPase, K subunit COG0636 Cluster_79481 V1218702 S Pfam:DUF88 COG1432 Cluster_135065 V1218703 P Major facilitator superfamily MFS_1 11HZQ Cluster_554756 V1218704 ISCR K Transcriptional regulator, BadM Rrf2 family COG1959 Cluster_104000 V1218705 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_589247 V1218706 S Protein of unknown function (DUF1294) 0ZYFY Cluster_167679 V1218707 VRAB map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map02020 I acetyl-CoA COG0183 Cluster_417945 V1218708 M Cell wall anchor domain protein 0YMXG Cluster_322952 V1218709 S Sortase family 11T4H Cluster_318425 V1218710 S Lpxtg-motif cell wall anchor domain protein 0XQBH Cluster_93746 V1218711 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_695901 V1218713 CAS2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) COG1343 Cluster_540116 V1218715 SCLAV_2692 E ABC transporter COG1123 Cluster_319907 V1218716 DPRE2 I, Q short-chain dehydrogenase reductase COG1028 Cluster_221973 V1218717 DPRE1 C FAD linked oxidase domain protein COG0277 Cluster_134267 V1218718 PHON map00627,map00740,map01120,map02020 I Phosphoesterase, PA-phosphatase related COG0671 Cluster_117714 V1218720 F permease COG2233 Cluster_206123 V1218721 C pyridine nucleotide-disulfide oxidoreductase family protein COG1252 Cluster_576411 V1218722 BMPA S basic membrane COG1744 Cluster_145716 V1218723 APGM map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG3635 Cluster_96808 V1218724 P transporter COG0471 Cluster_805092 V1218730 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_20151 V1218731 ADDA L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation COG1074 Cluster_58280 V1218732 MDLA V ABC transporter, ATP-binding protein COG1132 Cluster_421511 V1218733 XYLG S ABC transporter COG3845 Cluster_177786 V1218734 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_182987 V1218736 YIUA map02010 P Periplasmic binding protein COG0614 Cluster_114878 V1218737 NORM V Mate efflux family protein COG0534 Cluster_177787 V1218738 S X-X-X-Leu-X-X-Gly heptad repeats COG1511 Cluster_62372 V1218739 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_74815 V1218741 S NA 0Y12I Cluster_341004 V1218742 CAS6 L CRISPR-associated protein cas6 11MM9 Cluster_305169 V1218743 S Phospholipase, patatin family 0YEF4 Cluster_238609 V1218744 BL02952 S Membrane COG1434 Cluster_724878 V1218746 S prevent-host-death family 124KH Cluster_71234 V1218747 ABGT H Transporter COG2978 Cluster_170323 V1218748 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_414363 V1218749 RECR map03440 L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) COG0353 Cluster_502303 V1218750 S Phage-Associated Protein 120JX Cluster_114879 V1218751 K, L domain protein COG0553 Cluster_711579 V1218752 S VRR-NUC domain protein 122HE Cluster_20614 V1218753 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_183804 V1218754 D ATPase MipZ 0ZR7H Cluster_407061 V1218755 COMF S Competence protein COG1040 Cluster_105807 V1218756 XASA E amino acid COG0531 Cluster_347323 V1218757 XTHA map03410 L Exodeoxyribonuclease III COG0708 Cluster_430960 V1218758 K MarR family Transcriptional regulator 12CGG Cluster_648835 V1218759 S NA 11ZSB Cluster_471485 V1218760 MUTT3 L nudix hydrolase COG0494 Cluster_695902 V1218761 MT0425 S secreted protein 10SG5 Cluster_302218 V1218762 BMUL_5125 S UPF0317 protein COG4336 Cluster_291294 V1218764 S NA 0XQ6D Cluster_196965 V1218765 MT3095 S Methionine synthase vitamin-b12 independent 0XYJG Cluster_171968 V1218766 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_269737 V1218768 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_71514 V1218769 S NA 0YK1E Cluster_233696 V1218770 YYBS S Membrane COG4241 Cluster_342526 V1218771 K, L Inherit from COG: helicase COG0553 Cluster_421513 V1218772 YGFC K Transcriptional regulator 120E9 Cluster_196148 V1218773 S NA 0XS0Q Cluster_569972 V1218776 RPSP map03010 J 30s ribosomal protein S16 COG0228 Cluster_449007 V1218777 S Rhodanese domain protein 11KPM Cluster_179502 V1218778 OCAR_5156 E transglutaminase domain protein COG1305 Cluster_473596 V1218779 S NA 11FFJ Cluster_69258 V1218780 M NA 0YDBK Cluster_123461 V1218781 TRPB map00260,map00400,map01100,map01110,map01230 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) COG0133 Cluster_205047 V1218782 TRKH P Potassium uptake protein COG0168 Cluster_295434 V1218786 POTC map02010 P putrescine abc transporter COG1177 Cluster_392956 V1218787 S NA 11H00 Cluster_239879 V1218788 S esterase 1294K Cluster_124095 V1218789 HOM E saf domain-containing protein COG4091 Cluster_9877 V1218790 FAS map00061,map00350,map00362,map00627,map00642,map00903,map01100,map01120 I synthase COG4982 Cluster_277704 V1218791 S Secreted protein COG1376 Cluster_48073 V1218792 PKNG map05152 T Serine Threonine protein kinase COG0515 Cluster_121390 V1218793 ALL2459 S ATP GTP Binding Protein 0XQ3U Cluster_162886 V1218794 YDJZ S SNARE associated Golgi protein-related protein COG0398 Cluster_130339 V1218795 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_520374 V1218796 SAGG map02010 V ABC transporter, ATP-binding protein COG1131 Cluster_621530 V1218802 CKL_1885 S Protein of unknown function (DUF1064) 1251H Cluster_412492 V1218805 TNPR L resolvase COG1961 Cluster_26149 V1218808 T serine threonine protein kinase PknL (EC 2.7.11.1) COG2815 Cluster_589248 V1218809 MT2231 K transcriptional regulatory protein 11UQP Cluster_24067 V1218810 TRSE U traE protein COG3451 Cluster_333541 V1218811 ISTB L IstB domain-containing protein ATP-binding protein COG1484 Cluster_90912 V1218812 CVAR_1349 L Transposase COG4584 Cluster_554759 V1218813 TNPB L integrase catalytic COG2801 Cluster_288689 V1218814 NORM V Mate efflux family protein COG0534 Cluster_194419 V1218815 TSB map00260,map00270,map01100,map01230 E Cysteine synthase COG0031 Cluster_137476 V1218816 SSCG_02586 map00300,map01100,map01110,map01120,map01230 E decarboxylase COG0019 Cluster_189022 V1218818 S 5-bromo-4-chloroindolyl phosphate hydrolysis protein 111JX Cluster_177788 V1218819 TELA P Resistance protein COG3853 Cluster_45763 V1218821 MUTL map03430 L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) COG0323 Cluster_227761 V1218822 YBHK S UPF0052 protein COG0391 Cluster_259044 V1218823 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_358758 V1218824 YEBC K transcriptional regulatory protein COG0217 Cluster_557677 V1218825 MRNC S Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) COG1939 Cluster_310725 V1218826 map00230 S phosphorylase 11F11 Cluster_319908 V1218827 SOJ D Chromosome Partitioning Protein COG1192 Cluster_504702 V1218828 S ASCH domain 0Y0UK Cluster_307865 V1218829 S domain protein 0XNZW Cluster_148822 V1218830 S hi0933 family COG2081 Cluster_657041 V1218831 CUTA S divalent ion tolerance protein COG3323 Cluster_188178 V1218833 MT1293 map00350,map00362,map00627,map00642,map00903,map01120 I Acyl-transferase COG1835 Cluster_307866 V1218834 L TatD-related deoxyribonuclease COG0084 Cluster_87688 V1218835 S peptidase, S41 11FNN Cluster_313741 V1218837 S peptidase, S41 11FNN Cluster_551895 V1218838 M rhs family COG3209 Cluster_517823 V1218839 S Yqey-like protein COG1610 Cluster_107051 V1218840 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_216129 V1218841 M RND family efflux transporter COG0845 Cluster_347324 V1218842 RSUA J Pseudouridine synthase COG1187 Cluster_123462 V1218843 YWDH map00010,map00040,map00053,map00071,map00280,map00281,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00626,map00640,map00903,map01100,map01110,map01120 C Aldehyde dehydrogenase COG1012 Cluster_408821 V1218844 CPSD M Capsular exopolysaccharide family COG0489 Cluster_384103 V1218845 S Secreted protein 0XS2C Cluster_85536 V1218846 PUTP E Sodium proline symporter COG0591 Cluster_159541 V1218847 map02010 V ABC transporter 0XPIZ Cluster_554760 V1218848 MURG map00550,map01100,map04112 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) COG0707 Cluster_66857 V1218849 FTSW map04112 D Cell division protein, FtsW COG0772 Cluster_250307 V1218850 MURD map00471,map00550,map01100 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COG0771 Cluster_148083 V1218851 CAP5O map00051,map00363,map00520,map00591,map00625,map00650,map01100,map01120 M Dehydrogenase COG0677 Cluster_367005 V1218853 SPOU map00340,map00350,map00624,map01120 J tRNA rRNA methyltransferase COG0566 Cluster_280367 V1218854 S YhhN-like protein 0YYMV Cluster_785211 V1218855 YAAA S s4 domain protein COG2501 Cluster_159542 V1218856 DLPA map00020,map00290,map00480,map00720,map01100,map01110,map01120,map01210,map01230,map04146 E Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) COG0473 Cluster_446985 V1218857 S NA 11QTP Cluster_401787 V1218858 S Triacylglycerol lipase COG1075 Cluster_303662 V1218859 S Inherit from COG: Pfam:DUF567 COG4894 Cluster_436942 V1218860 S intracellular protease Pfpi family COG0693 Cluster_718199 V1218861 S phage protein 1262M Cluster_329087 V1218862 FABG map00061,map00780,map01040,map01100 S 3-oxoacyl- acyl-carrier-protein reductase 0XNW1 Cluster_143466 V1218863 FABF map00061,map00780,map01100 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) COG0304 Cluster_603175 V1218864 MMUM map00270,map01100,map01110 E Homocysteine COG2040 Cluster_81343 V1218865 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_56501 V1218867 PEPF map04614,map05143 E Oligoendopeptidase f COG1164 Cluster_203969 V1218869 FECD map02010 P Permease protein COG0609 Cluster_86821 V1218870 GATA map00970,map01100 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) COG0154 Cluster_128892 V1218871 VMRA V Mate efflux family protein COG0534 Cluster_446986 V1218873 YTQB map00340,map00350,map00624,map01120 Q rRNA Methylase COG0500 Cluster_154453 V1218874 YTFP S hi0933 family COG2081 Cluster_269738 V1218875 CMK map00240,map00410,map00770,map01100,map01110 F Cytidine monophosphate kinase COG0283 Cluster_89507 V1218876 MURE map00300,map00550,map01100 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_154454 V1218878 PAC S PAC2 family 0XNTG Cluster_332050 V1218879 NAGB map00520,map01100,map01110 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COG0363 Cluster_102253 V1218880 LMRB P Drug resistance transporter EmrB QacA 0ZVC8 Cluster_232428 V1218881 ACEE map00010,map00020,map00620,map00650,map01100,map01110,map01120 C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) COG2609 Cluster_394764 V1218883 MT2317 S Protein of unknown function (DUF3145) 11JAC Cluster_276396 V1218884 MT2318 V Beta-lactamase COG1680 Cluster_24361 V1218885 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_436943 V1218886 S degv family COG1307 Cluster_129613 V1218887 S Transporter Permease Protein 0ZURF Cluster_198889 V1218888 PHOH2 T Phoh family COG1875 Cluster_39630 V1218889 MT3737 S NA 0YAW9 Cluster_300829 V1218892 GG9_0942 L transposase COG2801 Cluster_440949 V1218893 L Transposase 11M0T Cluster_199886 V1218894 PURT map00230,map00670,map01100,map01110 F Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR COG0027 Cluster_545937 V1218895 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_144216 V1218896 HEMZ map00860,map01100,map01110 H coproporphyrinogen III oxidase COG0635 Cluster_526071 V1218897 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_377053 V1218898 LGAS_0604 V Hnh endonuclease 0XUCJ Cluster_236089 V1218901 SERA map00260,map00680,map01100,map01120,map01230 E Dehydrogenase COG0111 Cluster_279062 V1218902 M secretion protein, HlyD family COG0845 Cluster_170324 V1218903 map02010 V ABC-2 type transporter 0ZVIN Cluster_266988 V1218904 map02010 V ABC-2 type transporter 0ZVIN Cluster_809132 V1218905 V abc transporter permease protein 0ZW5X Cluster_361990 V1218906 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_273711 V1218907 T Histidine kinase COG0642 Cluster_378827 V1218908 T response regulator COG0745 Cluster_268390 V1218909 S YitT family COG1284 Cluster_307867 V1218910 PDXK map00750,map01100 H Pyridoxal kinase COG2240 Cluster_150449 V1218911 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_72482 V1218914 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_560743 V1218916 S NA 11YG8 Cluster_436944 V1218919 SCLAV_4066 S NA 11QJK Cluster_793004 V1218920 RV3193C S UPF0182 protein COG1615 Cluster_551896 V1218921 NDK map00230,map00240,map01100,map01110 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) COG0105 Cluster_131123 V1218922 L transposase, IS605 OrfB COG0675 Cluster_105190 V1218925 IROC map02010 V abc transporter COG1132 Cluster_89059 V1218926 map00020,map00310,map00380,map01100,map01110,map01120 C 2-oxoglutarate dehydrogenase, E1 subunit COG0567 Cluster_140509 V1218928 SPOVK O AAA ATPase, central domain protein COG0464 Cluster_766219 V1218929 S Abi-like protein 11VSQ Cluster_166141 V1218934 S NA 0YF9C Cluster_389413 V1218935 S NA 0YN8E Cluster_350556 V1218936 S NA 0YJH0 Cluster_108795 V1218937 GLPD1 map00564 C Glycerol-3-phosphate dehydrogenase COG0578 Cluster_224331 V1218938 EAPA map00565,map01100,map04146 C FAD linked oxidase domain protein COG0277 Cluster_875908 V1218939 S NA 0ZIXX Cluster_298179 V1218941 ELI_3039 K RNA Polymerase 1261F Cluster_322953 V1218944 S Pfam:DUF1994 0XRWZ Cluster_617869 V1218947 S Protein of unknown function (DUF1292) 1248N Cluster_469337 V1218948 MT1505 map02010 V ABC transporter COG1131 Cluster_64020 V1218949 MPTB S Membrane 0XTGY Cluster_599608 V1218950 S NA 0Y86C Cluster_502304 V1218951 YBBK J Purine nucleoside phosphorylase COG1683 Cluster_78408 V1218955 PROTEASE map05120 O peptidase, U32 COG0826 Cluster_596095 V1218956 SORA C Superoxide reductase COG2033 Cluster_126802 V1218957 E amidohydrolase COG1473 Cluster_113504 V1218958 V Mate efflux family protein COG0534 Cluster_280368 V1218960 V transporter, permease 10BP7 Cluster_417946 V1218961 SIGC K rna polymerase sigma factor COG1595 Cluster_438977 V1218962 S NA 0XXJW Cluster_537310 V1218964 S NA 11TBU Cluster_205048 V1218965 S relaxase mobilization nuclease domain protein 0XNXG Cluster_614095 V1218966 S NA 11NGD Cluster_127492 V1218975 LYSP E permease COG0833 Cluster_152883 V1218976 CRTL map00363,map00624,map00627,map00903,map00906,map00945,map01100,map01110,map01120 I LycopEne 0XPIY Cluster_769955 V1218977 YBIT S ABC transporter COG0488 Cluster_90422 V1218978 M Cell wall anchor domain protein 11Q8J Cluster_499770 V1218980 S Inherit from NOG: Ribosomal protein 1272F Cluster_265676 V1218982 RBSK map00030 G ribokinase COG0524 Cluster_805093 V1218986 PARB K parb-like partition protein COG1475 Cluster_158691 V1218988 S NIF3 (NGG1p interacting factor 3) COG3323 Cluster_295435 V1218989 COBC map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01230 E Aminotransferase COG0079 Cluster_12958 V1218990 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_182988 V1218991 PGN_0050 S NA 0XNWW Cluster_738005 V1218992 PGN_0051 S NA 0YP2S Cluster_421514 V1218993 SCLAV_1351 M Secreted protein COG0791 Cluster_245159 V1218994 TRXB map00240,map00450 O thioredoxin reductase COG0492 Cluster_111430 V1218995 L Integrase COG0582 Cluster_813116 V1218999 ATPG map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) COG0224 Cluster_97882 V1219000 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_199887 V1219001 RARA L recombination factor protein RarA COG2256 Cluster_63461 V1219002 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_157817 V1219003 UGPB map02010 G extracellular solute-binding protein family 1 COG1653 Cluster_344115 V1219004 GLPQ map00564 C glycerophosphoryl diester phosphodiesterase COG0584 Cluster_300830 V1219006 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_141265 V1219008 FRUA map00051,map01100,map02060 G PTS System COG1762 Cluster_226629 V1219009 FRUK map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G 1-phosphofructokinase COG1105 Cluster_22870 V1219010 FTSK D cell division protein FtsK COG1674 Cluster_813117 V1219011 TERC P integral membrane protein, terc COG0861 Cluster_249047 V1219012 S tetrapyrrole methylase COG3956 Cluster_230090 V1219013 DAPF E Diaminopimelate epimerase COG0253 Cluster_789210 V1219014 PCRA map03420,map03430 L DNA helicase COG0210 Cluster_13778 V1219015 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_268391 V1219016 THIG map00730,map01100 H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) COG2022 Cluster_762250 V1219017 THIS map04122 H Thiamine biosynthesis protein thiS 0ZZQD Cluster_236090 V1219018 THIO map00730 E glycine oxidase COG0665 Cluster_115561 V1219019 K Inherit from COG: Transcriptional regulator COG2865 Cluster_419717 V1219021 Y1676 S DUF218 domain COG1434 Cluster_312252 V1219022 PAAF map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00630,map00640,map00650,map00720,map00903,map00930,map01100,map01110,map01120,map01220 I Enoyl-CoA hydratase COG1024 Cluster_318426 V1219023 S cyclase, family COG1878 Cluster_279064 V1219024 O Erythromycin esterase COG2312 Cluster_796951 V1219025 D, J addiction module toxin, RelE StbE family COG2026 Cluster_309282 V1219026 DRAG O ADP-ribosylation crystallin J1 COG1397 Cluster_434889 V1219027 CHRA P Chromate COG2059 Cluster_531625 V1219030 YAJC map03060,map03070 U preprotein translocase, subunit YajC COG1862 Cluster_569973 V1219031 S NA 0Z261 Cluster_528837 V1219032 S Rubrerythrin 12ADX Cluster_669756 V1219033 S NA 12840 Cluster_523151 V1219034 M acetyltransferase COG1247 Cluster_218462 V1219035 I Diacylglycerol kinase COG1597 Cluster_585938 V1219036 RNFA C Electron transport complex COG4657 Cluster_109427 V1219037 FUMC map00020,map00720,map01100,map01110,map01120,map05200,map05211 C fumarate hydratase class II COG0114 Cluster_107631 V1219038 S s-layer domain-containing protein 122G9 Cluster_754960 V1219039 K Transcriptional regulator 120E9 Cluster_253998 V1219041 map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) COG1156 Cluster_124096 V1219042 ILVD map00290,map00770,map01100,map01110,map01210,map01230 E Dihydroxy-acid dehydratase COG0129 Cluster_348939 V1219043 S NA 0YS7C Cluster_456892 V1219044 S Membrane COG2259 Cluster_353722 V1219045 BLT G major facilitator superfamily 0ZVHM Cluster_548994 V1219046 L mutator MutT protein COG0494 Cluster_73148 V1219047 L type iii restriction protein res subunit COG3886 Cluster_93295 V1219048 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_370331 V1219049 MT1047 K Tetr family transcriptional regulator 0XSTJ Cluster_603176 V1219050 GLPX map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120 G Fructose-1,6-bisphosphatase COG1494 Cluster_371951 V1219051 YFHF M epimerase COG4276 Cluster_102798 V1219052 GLMU map00520,map01100,map01110 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) COG1207 Cluster_330487 V1219053 NPDA map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_563697 V1219054 S Zn-finger containing protein 121ND Cluster_273712 V1219055 SSCG_06117 S degv family COG1307 Cluster_117715 V1219056 CG2284 C uridylyltransferase COG1085 Cluster_769956 V1219057 GDHA map00250,map00330,map00910,map01100 E Glutamate dehydrogenase COG0334 Cluster_367006 V1219058 MGTC S MgtC SapB transporter COG1285 Cluster_751510 V1219059 S NA 0Y39F Cluster_385868 V1219060 HISB map00340,map01100,map01110,map01230 E imidazole-glycerol-phosphate dehydratase COG0131 Cluster_148084 V1219061 G Major Facilitator superfamily 11Q79 Cluster_228942 V1219063 RUMA map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_288690 V1219064 S NA 0Y1DS Cluster_176130 V1219065 FECD map02010 P ABC transporter permease COG0609 Cluster_592613 V1219066 FECE map02010 P ABC transporter COG1120 Cluster_754961 V1219067 TNPB L integrase catalytic COG2801 Cluster_777350 V1219068 TNPB L integrase catalytic COG2801 Cluster_265677 V1219069 PSTC map02010 P phosphate abc transporter COG0573 Cluster_15404 V1219070 HRPA L ATP-dependent helicase COG1643 Cluster_39149 V1219071 S NA 11MYY Cluster_394765 V1219072 S Signal transduction histidine kinase, lyts 11GMZ Cluster_335047 V1219073 map02010 P Cobalt transport protein COG0619 Cluster_284484 V1219074 CBIO2 map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_428989 V1219075 CBIO1 map02010 P ABC transporter COG1122 Cluster_326027 V1219077 RSEP map04112 M Membrane-associated zinc metalloprotease COG0750 Cluster_180323 V1219078 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_22353 V1219079 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_442963 V1219080 V type i restriction COG0732 Cluster_206124 V1219083 SP_1222 V restriction endonuclease 0ZVJ1 Cluster_242531 V1219084 TRXB map00240,map00450 O thioredoxin reductase COG0492 Cluster_892129 V1219085 GRDA S reductase complex 0XWGN Cluster_360423 V1219086 TRMK S SAM-dependent methyltransferase COG2384 Cluster_146513 V1219087 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_139781 V1219088 MT1736 S thiamin pyrophosphokinase catalytic COG4825 Cluster_674148 V1219091 COBC map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01230 E Aminotransferase COG0079 Cluster_531626 V1219092 PTPA T protein tyrosine phosphatase COG0394 Cluster_382328 V1219093 THIE map00730,map01100 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) COG0352 Cluster_551897 V1219094 S NA 0Y3IW Cluster_617870 V1219095 K Transcriptional regulator, GntR family COG1725 Cluster_333542 V1219096 FAT map00061,map01100 I Acyl-ACP thioesterase COG3884 Cluster_262964 V1219097 SERB map00260,map00680,map01100,map01120,map01230 E phosphoserine phosphatase COG3830 Cluster_341005 V1219098 ISPD map00900,map01100,map01110 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COG1211 Cluster_502305 V1219099 RIMP S Required for maturation of 30S ribosomal subunits (By similarity) COG0779 Cluster_221974 V1219100 YQFA S UPF0365 protein COG4864 Cluster_203970 V1219101 S NA 0ZN4K Cluster_65394 V1219102 TREZ map00500,map01100,map01110 G maltooligosyl trehalose trehalohydrolase COG0296 Cluster_705346 V1219103 S NA 128RN Cluster_166142 V1219106 GSPE map03070 U type ii secretion system protein e COG2804 Cluster_171149 V1219111 YLBM S UPF0348 protein COG1323 Cluster_16557 V1219112 XYLS map00052,map00500,map01100 G hydrolase, family 31 COG1501 Cluster_557679 V1219113 OCAR_5646 S Protein of unknown function DUF126 COG1786 Cluster_200888 V1219114 G Bacterial extracellular solute-binding protein, family 7 COG1638 Cluster_296778 V1219115 AROF map00400,map01100,map01110,map01230 E phospho-2-dehydro-3-deoxyheptonate aldolase COG2876 Cluster_67524 V1219116 T Histidine kinase 0XNMH Cluster_105191 V1219117 BIOA map00780,map01100 H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) COG0161 Cluster_357087 V1219118 BIOD map00780,map01100 H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) COG0132 Cluster_820701 V1219119 GLNE O, T Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) COG1391 Cluster_851749 V1219121 G Major Facilitator superfamily 0XPEM Cluster_227762 V1219123 NRNA J phosphoesterase RecJ domain protein COG0618 Cluster_599609 V1219124 RBFA J Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) COG0858 Cluster_341006 V1219125 LGAS_0583 S Replication Protein 0YVZX Cluster_114201 V1219126 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_280369 V1219127 DAPA map00300,map01100,map01110,map01120,map01230 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) COG0329 Cluster_107052 V1219128 GLYQS map00970 J Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) COG0423 Cluster_446987 V1219131 S NA 11XFF Cluster_64575 V1219132 ABIR S abortive phage infection 0XQE9 Cluster_444943 V1219133 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_214998 V1219134 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_189023 V1219135 E, T Extracellular solute-binding protein family 3 0YHUR Cluster_430961 V1219136 PKNG map05152 T Serine Threonine protein kinase COG0515 Cluster_37491 V1219137 V ATPase associated with various cellular activities aaa_5 COG1401 Cluster_408822 V1219138 KDPC map02020 P One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) COG2156 Cluster_333543 V1219139 KDPE map02020 T Response regulator receiver domain protein COG0745 Cluster_785213 V1219143 S NA 0ZYXP Cluster_41695 V1219144 MGTE P magnesium transporter COG2239 Cluster_302219 V1219146 map00561,map01100 S Secretory lipase 0YTM1 Cluster_370332 V1219147 LIPS2 map00561,map01100 S Secretory lipase 0YTM1 Cluster_427093 V1219148 COBN map00860,map01100 H cobaltochelatase, cobn subunit COG1429 Cluster_269739 V1219149 UGPE map02010 P ABC transporter COG0395 Cluster_262965 V1219150 UGPA map02010 P binding-protein-dependent transport systems inner membrane Component COG1175 Cluster_196149 V1219151 HEPT map00900,map01110 H synthase COG0142 Cluster_213817 V1219152 RV0561C map00860,map00900,map01100,map01110 C geranylgeranyl reductase COG0644 Cluster_365301 V1219153 TLPA O Thioredoxin family COG0526 Cluster_112038 V1219154 APEA map00480,map01100 E M18 family aminopeptidase COG1362 Cluster_193483 V1219155 RV3230C C oxidoreductase COG1018 Cluster_171150 V1219156 BDHA map00010,map00051,map00071,map00350,map00363,map00591,map00625,map00626,map00650,map00830,map00980,map00982,map01100,map01110,map01120 C alcohol dehydrogenase COG1979 Cluster_599610 V1219157 C Alcohol dehydrogenase zinc-binding domain protein COG1063 Cluster_249048 V1219158 COBW S Cobalamin synthesis protein cobW C-terminal domain COG0523 Cluster_473597 V1219159 MUG map03410 L U mismatch-specific DNA glycosylase COG3663 Cluster_189883 V1219160 COBD map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01230 E decarboxylase COG0079 Cluster_487262 V1219162 CARD K Transcriptional regulator (CarD family COG1329 Cluster_316855 V1219163 PGL map00030,map01100,map01110,map01120 G 6-phosphogluconolactonase (EC 3.1.1.31) COG0363 Cluster_109428 V1219164 RV1842C P integral membrane protein COG1253 Cluster_164492 V1219165 RHLE map03018 L atp-dependent rna helicase COG0513 Cluster_526072 V1219167 COMGF U comG operon protein 6 COG4940 Cluster_233697 V1219169 YTXK L Adenine-specific COG0827 Cluster_80162 V1219170 map00550,map01100 M glycosyl transferase, family 51 COG0744 Cluster_394766 V1219171 TRAK S Conjugative transposon TraK protein 0YYBW Cluster_674149 V1219172 TRAL S NA 11MPG Cluster_116996 V1219173 TRAM S Conjugative transposon TraM protein 0XQI8 Cluster_632863 V1219174 map02010 K Transcriptional regulator 10Z7N Cluster_262966 V1219175 S Inherit from COG: Aminoglycoside phosphotransferase COG3173 Cluster_531627 V1219176 S NA 11TBU Cluster_192598 V1219177 S relaxase mobilization nuclease domain protein 0XNXG Cluster_396553 V1219178 ENTB Q isochorismatase COG1335 Cluster_537311 V1219179 MSRB O reductase COG0229 Cluster_687560 V1219180 DAPE map00300,map00330,map01100,map01110,map01120,map01210,map01230 E succinyl-diaminopimelate desuccinylase COG0624 Cluster_218463 V1219182 DAPD map00300,map01100,map01120,map01230 E Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) COG2171 Cluster_377054 V1219183 PNUC H nicotinamide mononucleotide transporter COG3201 Cluster_132643 V1219185 S integral membrane protein 11VP2 Cluster_77816 V1219186 S smc domain-containing protein 0XTF4 Cluster_36870 V1219187 PRTP O peptidase S8 and S53, subtilisin, kexin, sedolisin COG2247 Cluster_20679 V1219188 V restriction enzyme COG1002 Cluster_454956 V1219189 KDSD M Arabinose 5-phosphate isomerase COG0794 Cluster_24823 V1219190 S Inherit from NOG: Histidine triad protein 11G35 Cluster_925408 V1219191 S NA 11FFJ Cluster_440950 V1219193 S peptidase C60 sortase A and B 128TE Cluster_531628 V1219195 ECHA3 map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120 I Enoyl-CoA hydratase COG1024 Cluster_232429 V1219196 SCLAV_4612 D Chromosome partitioning ATPase COG0455 Cluster_355395 V1219197 S Membrane 11K10 Cluster_25900 V1219198 V Type III COG3587 Cluster_220811 V1219200 RDGB map00230,map00240,map01100 F Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) COG0127 Cluster_458860 V1219201 YSNB S Phosphodiesterase, mj0936 family COG0622 Cluster_96809 V1219202 GATA map00970,map01100 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) COG0154 Cluster_33525 V1219203 NRDE map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_773620 V1219204 NRDE map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_324526 V1219205 PPID O Peptidyl-prolyl cis-trans isomerase COG0760 Cluster_305170 V1219206 AROE map00400,map01100,map01110,map01230 E shikimate COG0169 Cluster_169460 V1219208 DUSB J Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_66578 V1219209 TEX K domain protein COG2183 Cluster_284485 V1219210 S NA 0XZ8I Cluster_871825 V1219211 CG1711 C Aldo keto reductase COG0667 Cluster_116289 V1219212 MSHC map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_68895 V1219213 ARGS map00970 J arginyl-trna synthetase COG0018 Cluster_77817 V1219214 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_515153 V1219215 HSDS V restriction modification system DNA specificity COG0732 Cluster_80163 V1219217 L Site-specific recombinase COG1961 Cluster_617871 V1219218 S recombinase 11R6K Cluster_114202 V1219219 map02010 P ABC transporter COG1122 Cluster_300831 V1219220 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_327591 V1219221 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_303663 V1219222 PURC map00230,map01100,map01110 F SAICAR synthetase COG0152 Cluster_124097 V1219223 FADA2 map00071,map00072,map00280,map00281,map00310,map00350,map00362,map00380,map00592,map00620,map00627,map00630,map00640,map00642,map00650,map00720,map00900,map00903,map01100,map01110,map01120,map02020 I Acetyl-COA acetyltransferase COG0183 Cluster_674150 V1219225 map02020 V ABC transporter, permease COG0577 Cluster_206125 V1219226 OCAR_5486 H Molybdopterin binding domain protein COG0303 Cluster_387713 V1219227 I PAP2 Family COG0671 Cluster_115562 V1219230 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_430962 V1219231 P Chromate transport protein COG2059 Cluster_112764 V1219232 L integrase family 0ZJHZ Cluster_425160 V1219235 XPT map00230,map01100,map01110 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) COG0503 Cluster_55245 V1219236 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_38834 V1219237 MRCA map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_305171 V1219238 POTC map02010 P putrescine abc transporter COG1177 Cluster_438978 V1219239 RECX S Modulates RecA activity (By similarity) COG2137 Cluster_148823 V1219240 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG1372 Cluster_232430 V1219243 O Peptidase, M22 COG0533 Cluster_629041 V1219244 FUR P uptake regulator, fur family COG0735 Cluster_560744 V1219245 FTSL S Cell division protein FtsL 0XTK5 Cluster_239880 V1219246 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_321386 V1219247 THIE map00730,map01100 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) COG0352 Cluster_629042 V1219248 S Cupin 2, conserved barrel domain protein COG1917 Cluster_350557 V1219249 TRKA P domain protein COG0569 Cluster_313742 V1219250 MT0235 map00051 M glycosyl transferase group 1 COG0438 Cluster_68562 V1219251 MT0236 S conserved transmembrane protein 0ZV9J Cluster_434890 V1219253 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_48535 V1219254 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_867879 V1219255 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_253999 V1219257 S NA 1241G Cluster_104597 V1219260 APEA map00480,map01100 E M18 family aminopeptidase COG1362 Cluster_692090 V1219261 P cation diffusion facilitator family transporter COG0053 Cluster_62373 V1219262 S Abortive infection phage resistance protein 0YGER Cluster_64842 V1219263 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_85537 V1219264 S Conserved domain protein 0Y57B Cluster_156104 V1219266 SBND G Major Facilitator 0ZVCH Cluster_138240 V1219267 S NA 121Y4 Cluster_339551 V1219268 GLNQ E abc transporter atp-binding protein COG1126 Cluster_585939 V1219271 V Hnh endonuclease COG1403 Cluster_428990 V1219272 S Protein of unknown function (DUF1706) COG4283 Cluster_573187 V1219273 RV1042C L Transposase COG3293 Cluster_517824 V1219274 SSNG_01961 L Transposase COG3293 Cluster_86378 V1219277 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Involved in acetate metabolism (By similarity) COG0280 Cluster_188179 V1219278 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_517825 V1219279 S NA 11QKP Cluster_560745 V1219280 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_165334 V1219282 L Helicase COG4581 Cluster_48536 V1219283 MRCB map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_148085 V1219284 ATHE_0092 S Uncharacterised protein family (UPF0236) 0XRR3 Cluster_363558 V1219288 K Tetr family transcriptional regulator 11MWV Cluster_375283 V1219290 ATPA map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_292651 V1219291 ATPH map00190,map00195,map01100 C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) COG0712 Cluster_430963 V1219292 ATPF map00190,map00195,map01100 C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) COG0711 Cluster_153653 V1219293 S NA 11IN7 Cluster_560746 V1219294 S toxin secretion phage lysis holin COG4824 Cluster_298180 V1219295 M Cpl-7 lysozyme C-terminal domain protein 11GG1 Cluster_25309 V1219296 V Type I restriction-modification system R subunit COG4096 Cluster_341007 V1219298 LGT M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 Cluster_338120 V1219299 CPN_0573 K transcriptional regulatory protein COG0217 Cluster_338121 V1219300 NADE map00760,map01100 H nh(3)-dependent nad( ) synthetase COG0171 Cluster_456893 V1219302 CKL_1924 S Predicted membrane protein (DUF2335) COG5346 Cluster_380556 V1219303 SSCG_04455 S Methyltransferase 0XSGP Cluster_307868 V1219304 ETFB map00910 C Electron transfer flavoprotein COG2086 Cluster_42775 V1219307 S Inherit from NOG: LPXTG-motif cell wall anchor domain protein 0YEBJ Cluster_127493 V1219309 RARA L recombination factor protein RarA COG2256 Cluster_147285 V1219310 GLTS E Sodium Glutamate Symporter COG0786 Cluster_540118 V1219311 RARA L recombination factor protein RarA COG2256 Cluster_207232 V1219316 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_329088 V1219318 HSDM V type I restriction-modification system COG0286 Cluster_224332 V1219319 RV0224C map00340,map00350,map00624,map01120 S methyltransferase 0XTDB Cluster_566892 V1219320 MT0235 map00051 M glycosyl transferase group 1 COG0438 Cluster_44660 V1219322 FTSI map00550,map01100 M penicillin-binding protein COG0768 Cluster_221977 V1219324 S Nucleotidyl transferase of unknown function (DUF1814) 0XP6B Cluster_382329 V1219325 PLAV_1224 S NA 0ZTDK Cluster_579513 V1219327 GTO2 O Glutathione S-transferase COG0435 Cluster_384104 V1219328 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_724879 V1219331 CYSK map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_332051 V1219332 YQEC S selenium-dependent hydroxylase accessory protein YqeC 11VFN Cluster_396555 V1219333 ILVB map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E acetolactate synthase COG0028 Cluster_156105 V1219335 TOPB L Dna topoisomerase COG0550 Cluster_238610 V1219337 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_167680 V1219338 map00561,map01100 M Glycosyl transferase (Group 1 COG0438 Cluster_394767 V1219339 YJBF S SNARE-like domain protein COG0398 Cluster_26781 V1219340 MTSD S NA 17UZ3@proNOG Cluster_714957 V1219341 L Addiction module antitoxin, RelB DinJ family COG3077 Cluster_27462 V1219342 TRAG map03070 U TraG TraD family protein COG3505 Cluster_100012 V1219344 MURE map00300,map00550 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_427094 V1219345 TETR K Tetr family transcriptional regulator 104NP Cluster_318428 V1219347 T Histidine kinase COG0642 Cluster_548995 V1219348 S Toxin-antitoxin system, antitoxin component, HicB family 12518 Cluster_828520 V1219349 S conserved domain protein 1280C Cluster_55497 V1219350 O cysteine protease COG4870 Cluster_537312 V1219352 M Arylsulfatase COG1368 Cluster_64021 V1219353 THRE S Amino acid export carrier protein COG3610 Cluster_168529 V1219354 CSD map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_54752 V1219355 TREY map00500,map01100,map01110 G malto-oligosyltrehalose synthase COG3280 Cluster_606784 V1219356 L Recombinase COG1961 Cluster_463028 V1219359 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_44487 V1219360 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_606785 V1219361 HSDS V type I restriction modification DNA specificity domain COG0732 Cluster_341008 V1219362 V ABC transporter, ATP-binding permease protein COG1132 Cluster_79157 V1219363 PEAH map02010 V ABC transporter, ATP-binding protein COG1132 Cluster_303664 V1219364 SCPA S Segregation and condensation protein COG1354 Cluster_266989 V1219365 SOJ D cobyrinic Acid a,c-diamide synthase COG1192 Cluster_367008 V1219369 YGFZ map00260,map00670,map00910,map01100 S Folate-binding protein YgfZ COG0354 Cluster_257723 V1219370 PABC map00280,map00290,map00770,map00790,map01100,map01110,map01210,map01230 E Aminotransferase COG0115 Cluster_370333 V1219371 I May play a role in the intracellular transport of hydrophobic ligands 11G4X Cluster_371952 V1219372 S Chromosome segregation ATPase 11HKQ Cluster_284486 V1219373 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_394768 V1219374 S nuclear export factor GLE1 COG4549 Cluster_499771 V1219375 MHQR K transcriptional regulator), MarR family 11UT8 Cluster_425161 V1219376 S Nitroreductase COG3560 Cluster_28066 V1219377 ACNA map00020,map00300,map00630,map00720,map01100,map01110,map01120,map01210,map01230 C aconitate hydratase COG1048 Cluster_145717 V1219378 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_148086 V1219379 SCLAV_0831 E alanine racemase domain protein COG3616 Cluster_206126 V1219380 GULO map00053,map01100 C oxidoreductase COG0277 Cluster_401789 V1219382 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_230091 V1219383 C Alcohol dehydrogenase zinc-binding domain protein COG0604 Cluster_661274 V1219385 S Pfam:Phage_QLRG 0XZ9J Cluster_648837 V1219386 YERC S protein, YerC YecD COG4496 Cluster_661275 V1219387 S NA 0XW7Q Cluster_319909 V1219388 KDPD map02020 T Osmosensitive K channel His kinase sensor COG2205 Cluster_62085 V1219389 V ABC transporter COG1132 Cluster_28863 V1219390 M domain protein COG4932 Cluster_34030 V1219391 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_97357 V1219392 PBUX F permease COG2233 Cluster_143467 V1219393 G Major Facilitator superfamily 0XPEM Cluster_231268 V1219394 E, H Thiamine pyrophosphate COG0028 Cluster_171969 V1219395 AARI_34710 L Transposase for insertion sequence 11IYJ Cluster_417947 V1219399 CARD K Transcriptional regulator (CarD family COG1329 Cluster_103424 V1219400 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_306559 V1219401 PPP map03070 T phosphatase COG0631 Cluster_254000 V1219402 I Diacylglycerol kinase COG1597 Cluster_523152 V1219403 S NA 0XWY0 Cluster_419719 V1219404 EBA2484 L AtP-binding protein COG1484 Cluster_68220 V1219405 MAQU_3187 L Integrase catalytic subunit COG4584 Cluster_250308 V1219406 S NA 0Z3WT Cluster_133480 V1219407 O AAA ATPase, central domain protein COG0464 Cluster_209401 V1219409 map00190,map00680,map01100 C ATP synthase (C/AC39) subunit 0ZXSZ Cluster_237294 V1219410 CORA P transporter COG0598 Cluster_363559 V1219411 YBJB S integral membrane protein COG4858 Cluster_754962 V1219412 RPSR map03010 J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) COG0238 Cluster_322955 V1219413 I CoA-substrate-specific enzyme activase COG1924 Cluster_303665 V1219414 S NA 0Y843 Cluster_96291 V1219417 V Restriction modification system DNA specificity domain protein COG0732 Cluster_621533 V1219418 S NA 0Y8FU Cluster_606787 V1219419 GCDC map00010,map00020,map00362,map00620,map00650,map01100,map01110,map01120 I biotin lipoyl attachment domaiN-containing protein COG0511 Cluster_170325 V1219420 Y3785 S Uncharacterized protein conserved in bacteria N-term (DUF3322) COG4924 Cluster_199888 V1219421 SBCC3 S Cytosolic protein COG4913 Cluster_391144 V1219422 CAS1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) COG1518 Cluster_809134 V1219423 FADD4 map00071,map01100,map03320,map04146,map04920 Q Amp-dependent synthetase and ligase COG0318 Cluster_95205 V1219424 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_305172 V1219426 T Histidine kinase COG4585 Cluster_678598 V1219427 SSCG_03030 map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_199889 V1219428 S NA 0Z59Q Cluster_170326 V1219429 AROA map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate synthase COG0128 Cluster_542993 V1219430 P Ferric uptake regulator, Fur family COG0735 Cluster_315327 V1219431 O Dehydrogenase COG1975 Cluster_295437 V1219432 YQEB O Selenium-dependent molybdenum hydroxylase system protein, YqeB family COG1975 Cluster_545938 V1219433 S NA 11ZGT Cluster_53279 V1219434 PROTEASE map05120 O Peptidase U32 COG0826 Cluster_219623 V1219435 S Pilin isopeptide linkage domain protein 1274N Cluster_456894 V1219436 CYSE map00270,map00920,map01100,map01120,map01230 E serine acetyltransferase COG1045 Cluster_214999 V1219437 S NA 0XTJ4 Cluster_417948 V1219438 SLGD_00062 S membrAne 11F2H Cluster_91864 V1219439 G transporter 0XNQK Cluster_380557 V1219440 UBIE map00130,map01100,map01110 H Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) COG2226 Cluster_156950 V1219441 MGTA map00051 M Glycosyl transferase (Group 1 COG0438 Cluster_211611 V1219442 ASNA map00250,map00460,map00910,map01100,map01110,map01230 E asparagine synthetase A COG2502 Cluster_648838 V1219443 SPOVG M Could be involved in septation (By similarity) COG2088 Cluster_89974 V1219444 L site-specific recombinase COG1961 Cluster_557680 V1219445 L Resolvase, N-terminal domain protein COG1961 Cluster_31843 V1219446 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_106414 V1219447 S RelA SpoT domain protein 0XPFE Cluster_252743 V1219448 I Lipid kinase, YegS Rv2252 BmrU family COG1597 Cluster_355396 V1219450 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_342527 V1219451 K Iclr family transcriptional regulator 11XKS Cluster_442964 V1219452 K Tetr family transcriptional regulator 11SFF Cluster_644781 V1219453 P multidrug resistance protein 126BZ Cluster_589250 V1219454 S NA 0ZS1W Cluster_227763 V1219457 S surface protein 11NE4 Cluster_375284 V1219458 VNCR T response regulator COG0745 Cluster_440951 V1219459 VEX3 V abc transporter permease protein COG0577 Cluster_494602 V1219460 S NA 125SF Cluster_449009 V1219461 WECD map00350,map00362,map00627,map00642,map00903,map01120 S -acetyltransferase 11PF0 Cluster_32309 V1219462 METH map00270,map00450,map00670,map01100,map01110,map01230 E Methionine synthase COG1410 Cluster_855527 V1219463 S single-strand binding family protein 0XS6K Cluster_218464 V1219464 K AraC Family Transcriptional Regulator COG2207 Cluster_247741 V1219465 U, W Hep Hag repeat protein COG5295 Cluster_66858 V1219466 GYRA2 L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_731458 V1219468 RPMC map03010 J 50s ribosomal protein l29 COG0255 Cluster_132644 V1219469 MGTE P magnesium transporter COG2239 Cluster_370334 V1219470 S Methyltransferase 11PHP Cluster_275064 V1219471 S NA 11HU2 Cluster_350558 V1219474 MT1102 S membrane COG4760 Cluster_563698 V1219476 Y2191 K Antirepressor COG3617 Cluster_291295 V1219477 S FhuF 2Fe-2S C-terminal domain 0XWKM Cluster_271051 V1219478 MT1287 S NA 11QDU Cluster_184680 V1219481 S Band 7 protein COG2268 Cluster_252744 V1219482 PROB map00330,map01100,map01230 E Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) COG0263 Cluster_216130 V1219483 E amidohydrolase COG1473 Cluster_176954 V1219484 E peptidase COG2195 Cluster_172877 V1219485 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_198890 V1219486 POTA map02010 E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COG3842 Cluster_446988 V1219487 PUUR K Transcriptional regulator COG1396 Cluster_652924 V1219489 LICA map02060 G PTS System COG1447 Cluster_657042 V1219490 LICB map02060 G PTS System COG1440 Cluster_257724 V1219491 S PEP phosphonomutase family protein 0XPW8 Cluster_208353 V1219492 K Transcriptional Regulator AraC Family 0ZYR5 Cluster_139782 V1219493 CODA map00240,map00330,map00791,map01100,map01120 F cytosine deaminase COG0402 Cluster_265678 V1219496 REP L Replication Protein COG5527 Cluster_243881 V1219498 YRRN map05120 O peptidase (U32 family) COG0826 Cluster_34197 V1219499 IROC map02010 V abc transporter COG1132 Cluster_566893 V1219500 S NA 0YSYB Cluster_236091 V1219501 S NA 11HGS Cluster_517826 V1219502 TRAA L TrwC relaxase COG0507 Cluster_380558 V1219503 RPLY map03010 J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) COG1825 Cluster_344116 V1219505 YABB map00340,map00350,map00624,map01120 L Methyltransferase COG4123 Cluster_281711 V1219506 YAAT S psp1 domain protein COG1774 Cluster_59074 V1219508 DXS map00730,map00900,map01100,map01110 H, I Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) COG1154 Cluster_163684 V1219511 SCLAV_3035 S Abi-like protein 11WV5 Cluster_186481 V1219512 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_480350 V1219513 GUAB1 map00230,map00983,map01100,map01110 F Dehydrogenase COG0517 Cluster_179503 V1219514 GLSA map00250,map00330,map00471,map00910,map01100,map01120,map04724,map04727,map04964 E Glutaminase COG2066 Cluster_421515 V1219516 S ATP GTP-binding protein 0XNYD Cluster_368621 V1219518 S NA 1119B Cluster_262967 V1219519 CRTB map00906,map01062,map01100,map01110 I phytoene synthase COG1562 Cluster_72822 V1219520 SSMG_01709 L transposase COG2826 Cluster_223156 V1219521 LIVM map02010 E amino acid COG4177 Cluster_378828 V1219524 MTSD S NA 17UZ3@proNOG Cluster_548998 V1219525 P tonB-dependent siderophore receptor COG1629 Cluster_72159 V1219529 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_507285 V1219530 SEPF S Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) COG1799 Cluster_285925 V1219533 map00330,map00360,map00380,map00627,map00643,map01120 Q K01426 amidase EC 3.5.1.4 COG0154 Cluster_285926 V1219534 ISPE map00900,map01100,map01110 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COG1947 Cluster_382330 V1219535 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_463029 V1219536 ISCU C SUF system FeS assembly protein COG0822 Cluster_484988 V1219537 SCLAV_1116 S metal-sulfur cluster biosynthetic COG2151 Cluster_358759 V1219540 S NA 11NM2 Cluster_403567 V1219541 C nitroreductase COG0778 Cluster_592614 V1219542 GST map00480,map00980,map00982,map05204 O Glutathione S-transferase COG0625 Cluster_85913 V1219543 COMM O Mg chelatase subunit ChlI COG0606 Cluster_134268 V1219544 L C-5 cytosine-specific DNA methylase COG0270 Cluster_138241 V1219545 MTAD F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) COG0402 Cluster_36685 V1219549 U, W Pfam:YadA COG5295 Cluster_629043 V1219550 LYSC map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Aspartokinase COG0527 Cluster_287333 V1219551 E, G Membrane COG0697 Cluster_355397 V1219552 LEUA map00290,map00620,map01100,map01110,map01210,map01230 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) COG0119 Cluster_695904 V1219553 S inner membrane protein YbaN COG2832 Cluster_155294 V1219554 KDPD map02020 T Histidine kinase COG2205 Cluster_329089 V1219555 KDPE map02020 T Two component transcriptional regulator, winged helix family COG0745 Cluster_180324 V1219556 CFA M cyclopropane-fatty-acyl-phospholipid synthase COG2230 Cluster_335049 V1219557 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_236092 V1219558 INSI L transposase COG2826 Cluster_114203 V1219559 ACTP E sodium solute COG4147 Cluster_632864 V1219560 SCLAV_1038 S integral membrane protein COG3162 Cluster_855528 V1219561 DKGA C reductase COG0656 Cluster_339552 V1219564 SRTB U sortase, SrtB family COG4509 Cluster_352058 V1219565 CASA L crispr-associated protein 0XPA1 Cluster_81344 V1219566 CYDC map02010 V Abc transporter COG1132 Cluster_537313 V1219567 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_652925 V1219570 FDXA C Ferredoxin COG1146 Cluster_175335 V1219571 DAPC map00300,map01100,map01120,map01230 E Aminotransferase COG0436 Cluster_225507 V1219572 ANSA map00250,map00460,map00910,map01100,map01110 E l-asparaginase (EC 3.5.1.1) COG0252 Cluster_173711 V1219574 ELRF S cutinase 11FQ6 Cluster_450980 V1219575 S secreted protein 11S0R Cluster_699181 V1219578 TNPA L transposase COG4644 Cluster_38134 V1219579 ESSC D ftsk spoIIIe COG1674 Cluster_442965 V1219581 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_148087 V1219584 LGAS_0605 S phage terminase large subunit 0XSCY Cluster_361991 V1219585 YHCW map00500 J HAD-superfamily hydrolase subfamily IA variant 3 COG0637 Cluster_104598 V1219586 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_385869 V1219587 GUAB3 map00230,map00983,map01100,map01110 F Dehydrogenase COG0516 Cluster_94166 V1219588 SUFB O FeS assembly protein SUFB COG0719 Cluster_434891 V1219589 K Transcriptional regulator 120E9 Cluster_200889 V1219590 S NA 0XNQB Cluster_48960 V1219591 S Membrane 0Y2EP Cluster_859530 V1219592 L ABC transporter COG0178 Cluster_512453 V1219593 K Tetr family transcriptional regulator 11SFF Cluster_89508 V1219594 SMVA G major facilitator superfamily COG0477 Cluster_387714 V1219597 S NA 12A75 Cluster_407062 V1219598 S Cutinase 0YUSA Cluster_138987 V1219599 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_492119 V1219600 YJEE S protein family UPF0079, ATPase COG0802 Cluster_225508 V1219601 CZCD P cation diffusion facilitator family transporter COG1230 Cluster_367009 V1219602 SRTA M (sortase) family COG3764 Cluster_107632 V1219604 GLPT map02020 G transporter COG2271 Cluster_330488 V1219605 CPPA S CppA protein 0ZGK6 Cluster_378829 V1219606 C Nitroreductase COG0778 Cluster_373571 V1219607 PFOR S Membrane COG3641 Cluster_569974 V1219609 SARE_3740 K Antirepressor COG3645 Cluster_50360 V1219612 S NA 0XPJ6 Cluster_482664 V1219613 RIMM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) COG0806 Cluster_70237 V1219615 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_161210 V1219616 L transposase 11GFI Cluster_310726 V1219618 G, M Inherit from COG: Capsular polysaccharide biosynthesis protein COG4464 Cluster_40710 V1219619 U, W Pfam:YadA COG5295 Cluster_824685 V1219621 S NA 0ZHU9 Cluster_126803 V1219622 PORAS_0418 L reverse transcriptase COG3344 Cluster_596097 V1219623 RPLN map03010 J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) COG0093 Cluster_731459 V1219624 RPSQ map03010 J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal COG0186 Cluster_796953 V1219625 RPMC map03010 J 50s ribosomal protein l29 COG0255 Cluster_599611 V1219626 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_734679 V1219627 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_114880 V1219628 BL03948 S nucleoside recognition domain protein COG3314 Cluster_844065 V1219629 SECE map03060,map03070 U Preprotein translocase SecE subunit 0XUXP Cluster_256438 V1219631 DNAI L Primosomal protein, DnaI COG1484 Cluster_370335 V1219632 DNAB L replication initiation and membrane attachment COG3611 Cluster_292652 V1219633 YXEH S hydrolase COG0561 Cluster_401790 V1219634 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_566894 V1219636 CDD map00240,map00983,map01100,map05219 F cytidine deaminase COG0295 Cluster_262968 V1219637 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_288691 V1219638 SDHA map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020,map05134 C succinate dehydrogenase, flavoprotein subunit COG1053 Cluster_51325 V1219639 S ATPase domain protein 125CS Cluster_542995 V1219640 K Bacterial regulatory proteins, tetR family COG1309 Cluster_206127 V1219641 PURM map00230,map01100,map01110 F phosphoribosylaminoimidazole synthetase COG0150 Cluster_396556 V1219642 PURF map00230,map00250,map01100,map01110 F glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_322956 V1219643 KDSB map00540,map01100 M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) COG1212 Cluster_371953 V1219644 SITB map02010,map02020 P (ABC) transporter COG1121 Cluster_246482 V1219645 SITA map02010,map02020 P periplasmic solute binding protein COG0803 Cluster_731460 V1219646 UBIE map00130,map01100,map01110 H Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) COG2226 Cluster_348940 V1219647 PYRC map00230,map00240,map00410,map00770,map00983,map01100,map01120 F dihydroorotase COG0044 Cluster_542996 V1219648 ISPG map00900,map01100,map01110 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) COG0821 Cluster_77818 V1219649 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_58038 V1219650 K Fibronectin-binding protein A N-terminus (FbpA) COG1293 Cluster_83394 V1219651 NNRD G Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) COG0063 Cluster_43134 V1219652 M Phage minor structural protein COG4926 Cluster_734680 V1219653 KATA map00380,map00630,map01110,map04146,map05014 P catalase COG0753 Cluster_96810 V1219654 S secreted protein 0YGV2 Cluster_370336 V1219655 COBI map00860,map01100 H Precorrin-2 c20-methyltransferase COG2243 Cluster_377055 V1219656 COBG map00860,map01100 H precorrin-3b synthase COG0155 Cluster_758488 V1219657 Q Mammalian cell entry related domain protein COG1463 Cluster_224333 V1219658 LYSR K transcriptional regulator, lysR family COG0583 Cluster_233698 V1219659 RIMO J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) COG0621 Cluster_497108 V1219660 BPR_I0156 L transposase COG1943 Cluster_867881 V1219661 GLTC K transcriptional regulator COG0583 Cluster_250309 V1219664 S NA 0YCC9 Cluster_551898 V1219667 DEF2 J peptide deformylase COG0242 Cluster_239881 V1219668 SCRK map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G fructokinase COG1940 Cluster_217334 V1219670 P Periplasmic binding protein COG0614 Cluster_465116 V1219671 C Nitroreductase COG0778 Cluster_444944 V1219672 S Acetyltransferase (GNAT) family 11Z04 Cluster_423374 V1219673 PCAD map00362,map01100,map01120 Q 3-oxoadipate enol-lactonase COG0596 Cluster_569976 V1219674 SCLAV_5538 S NA 11XKE Cluster_324528 V1219675 K LysR family Transcriptional regulator COG0583 Cluster_283110 V1219676 COF S hydrolase COG0561 Cluster_236093 V1219677 MT0809 C fumarate reductase succinate dehydrogenase flavoprotein domain protein COG3573 Cluster_166143 V1219679 ADH map00051,map00363,map00591,map00625,map00650,map01100,map01120 C iron-containing alcohol dehydrogenase COG1454 Cluster_205049 V1219681 PPA1638 S abc transporter 0XNT6 Cluster_239882 V1219682 SSCG_03007 S ABC, transporter 0XNW9 Cluster_145718 V1219683 S radical SAM domain protein COG4277 Cluster_403568 V1219684 YQGX map00620 Q domain protein COG0491 Cluster_178625 V1219685 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_396557 V1219686 FXSA S cytoplasmic membrane protein 12942 Cluster_102254 V1219688 NDH map00190 C NADH dehydrogenase COG1252 Cluster_134269 V1219689 PORAS_0418 L reverse transcriptase COG3344 Cluster_382332 V1219690 map02010 P ABC, transporter COG1120 Cluster_173712 V1219691 HMUU map02010 P permease protein COG0609 Cluster_262969 V1219693 FTSX map02010 D Part of the ABC transporter FtsEX involved in cellular division (By similarity) COG2177 Cluster_781091 V1219694 YRXA K 3H domain protein COG1827 Cluster_265679 V1219695 BMUL_3003 S Membrane COG3619 Cluster_603179 V1219696 K Transcriptional regulator, ARAC family COG2207 Cluster_318429 V1219697 LTRA L reverse transcriptase COG3344 Cluster_463030 V1219698 S hydrolase 11G9J Cluster_126098 V1219699 YFMR S abc transporter COG0488 Cluster_143468 V1219700 YAAO map00310,map00330,map00960,map01100,map01110 E decarboxylase COG1982 Cluster_777351 V1219701 V (ABC) transporter COG1131 Cluster_820704 V1219702 UDGA map00040,map00053,map00500,map00520,map01100,map01110 M Udp-glucose 6-dehydrogenase COG1004 Cluster_82121 V1219703 GLT map00630,map00910 E Glutamate synthase COG0069 Cluster_102799 V1219704 S S-layer domain protein 11R54 Cluster_249049 V1219705 RNFB C electron transport complex, RnfABCDGE type, B subunit COG2878 Cluster_203971 V1219706 VIRE2 S Virulence-associated protein e COG5545 Cluster_711582 V1219707 S Abortive infection protein AbiGII 0XQHH Cluster_416141 V1219709 S Abortive infection protein AbiGI 11WH3 Cluster_227764 V1219710 RARD S rard protein COG2962 Cluster_385870 V1219711 S NA 0ZUJG Cluster_355398 V1219712 TRMK S SAM-dependent methyltransferase COG2384 Cluster_465117 V1219714 S NA 0Y65N Cluster_566895 V1219715 TPDA E peptidase COG0624 Cluster_221978 V1219716 GALE map00052,map00520,map01100,map01110 M udp-glucose 4-epimerase COG1087 Cluster_377056 V1219717 IDER K iron (metal) dependent repressor, dtxr family COG1321 Cluster_789213 V1219718 PLSY map00561,map00564,map01100 S Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) COG0344 Cluster_239883 V1219719 ZNUA map02010 P periplasmic solute binding protein COG0803 Cluster_53280 V1219720 NIRK map00910,map01120 Q nitrite reductase COG2132 Cluster_69606 V1219721 NIST map02010 V ABC transporter 0XPIZ Cluster_773624 V1219722 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_73513 V1219723 PARE L Dna topoisomerase iv (Subunit b) COG0187 Cluster_542997 V1219724 LSA_01120 L Transposase COG1943 Cluster_711583 V1219728 VEG S Veg protein COG4466 Cluster_148824 V1219729 SERP0565 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_147286 V1219731 SULP P sulfate transporter COG0659 Cluster_380559 V1219732 S NA 0YE9N Cluster_48074 V1219733 U, W Pfam:YadA COG5295 Cluster_683124 V1219734 RUVX L Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) COG0816 Cluster_260348 V1219736 DCM map00270,map01100 L Inherit from proNOG: cytosine-specific methyltransferase COG0270 Cluster_175336 V1219740 L transposase, IS605 OrfB COG0675 Cluster_373572 V1219741 MGPA S DHH family COG0618 Cluster_425162 V1219742 S NA 0Y7IJ Cluster_748090 V1219743 V Type I restriction modification DNA specificity domain 11G07 Cluster_50361 V1219744 MT3888 S NA 11KBZ Cluster_793009 V1219745 V Abc transporter COG1132 Cluster_277705 V1219747 HBD map00360,map00362,map00650,map01100,map01120 I 3-hydroxyacyl-CoA dehydrogenase COG1250 Cluster_137478 V1219748 HYDF S gtp-binding protein COG1160 Cluster_49581 V1219749 M domain protein COG4932 Cluster_49371 V1219750 M domain protein COG4932 Cluster_417949 V1219751 YHJX G major facilitator superfamily 171GS@proNOG Cluster_321388 V1219752 FDHD C Necessary for formate dehydrogenase activity (By similarity) COG1526 Cluster_610451 V1219753 S Protein of unknown function (DUF2786) 11S2Y Cluster_230092 V1219754 S NA 0XPQF Cluster_288692 V1219755 RV1836C S VWA 11NEC Cluster_220812 V1219756 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_367010 V1219757 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_159543 V1219758 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_438979 V1219759 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_272378 V1219760 STRIC_0432 L Transposase (IS4 family 11HCS Cluster_50160 V1219761 map05132 M repeat protein COG3209 Cluster_836127 V1219762 S Relaxase mobilization nuclease 11PW0 Cluster_117716 V1219763 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_156106 V1219764 GLGC map00500,map00520,map01100,map01110 G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) COG0448 Cluster_124752 V1219765 SP_1683 G ABC, transporter COG1653 Cluster_157818 V1219766 ELI_1299 S Phage major capsid protein COG4653 Cluster_132645 V1219767 FPRA map00250,map00910,map01100,map01110,map01120,map01230 C reductase COG0493 Cluster_569977 V1219770 S Hydrolase COG1011 Cluster_62374 V1219771 MUTB map00280,map00630,map00640,map00720,map01100,map01120 I Methylmalonyl-coA mutase COG2185 Cluster_344117 V1219775 S NA 11US3 Cluster_51525 V1219777 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_148088 V1219780 S NA 0ZKKG Cluster_236094 V1219781 ARCC map00230,map00330,map00910,map01120 E carbamate kinase COG0549 Cluster_665451 V1219782 S phage protein 11QFY Cluster_629044 V1219783 S Phage head-tail adaptor 11JDV Cluster_526073 V1219784 S Phage protein, HK97 gp10 family 11K8D Cluster_674153 V1219785 CRES_0877 S NA 11IZ7 Cluster_718201 V1219786 NLAXM map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_467196 V1219788 MODB map02010 P molybdate abc transporter COG4149 Cluster_683125 V1219789 TMP1 S NA 10C99 Cluster_91376 V1219790 MOD map00340,map00350,map00624,map01120 L DNA methylase COG2189 Cluster_579515 V1219792 S NA 11W9N Cluster_367011 V1219795 RELA map00230 S RelA SpoT domain protein COG2357 Cluster_432970 V1219796 CYAA S Adenylate cyclase COG4116 Cluster_196966 V1219797 CAPA M Capsule synthesis protein COG2843 Cluster_428991 V1219798 RLMH S Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) COG1576 Cluster_195098 V1002001 YLOV S dak2 domain fusion protein ylov COG1461 Cluster_928073 V1002002 ASP S Alkaline-shock protein COG1302 Cluster_331740 V1002003 MALD map02010 P ABC transporter, permease COG3833 Cluster_525342 V1002004 MALC map02010 P permease protein COG1175 Cluster_396172 V1002005 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_528181 V1002006 CODA F deaminase COG0295 Cluster_253768 V1002009 RR07 map02020 T regulatoR COG4753 Cluster_730667 V1002010 HK07 map02020 T Histidine kinase COG2972 Cluster_545168 V1002013 PLSX map00561,map00564,map01100 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) COG0416 Cluster_327247 V1002014 RECO map03440 L Involved in DNA repair and RecF pathway recombination (By similarity) COG1381 Cluster_178470 V1002015 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_660227 V1002016 CINA H competence damage-inducible protein COG1546 Cluster_342176 V1002017 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_519774 V1002019 BDP_0120 L Transposase 11QWX Cluster_456448 V1002020 GG9_0942 L Transposase COG2801 Cluster_170980 V1002021 COPA P p-type ATPase COG2217 Cluster_179316 V1002022 CBPC M choline binding protein COG5263 Cluster_575627 V1002023 VICR map02020 T response regulator COG0745 Cluster_316546 V1002024 VICK map02020 T Histidine kinase 0XNMH Cluster_519775 V1002025 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_403141 V1002026 PANC map00410,map00770,map01100,map01110 H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) COG0414 Cluster_501689 V1002027 FCHA map00670,map01100 E Methenyltetrahydrofolate cyclohydrolase COG3404 Cluster_368276 V1002028 FTCD map00340,map00670,map01100 E Glutamate formiminotransferase COG3643 Cluster_293713 V1002031 S (LipO)protein 0XQK7 Cluster_208125 V1002032 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_647836 V1002033 TRXA O Thioredoxin COG0526 Cluster_343787 V1002034 TRXB map00240,map00450 O thioredoxin reductase COG0492 Cluster_188854 V1002035 S Membrane 11KXQ Cluster_464651 V1002036 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins COG0706 Cluster_493973 V1002037 YIDD S Could be involved in insertion of integral membrane proteins into the membrane (By similarity) COG0759 Cluster_743859 V1002039 SAES map02020 T Histidine kinase COG0642 Cluster_401358 V1002040 RPSD map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) COG0522 Cluster_378429 V1002041 MDLB V ABC transporter COG1132 Cluster_489009 V1002042 MDLA V ABC transporter transmembrane region COG1132 Cluster_174339 V1002043 YYBT T domain protein COG3887 Cluster_635837 V1002044 THIN map00730,map01100 H thiamine COG1564 Cluster_303327 V1002045 RMUC S RmuC domain protein COG1322 Cluster_175156 V1002046 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_176807 V1002047 ESSC D ftsk spoIIIe COG1674 Cluster_867004 V1002048 SPOU J rrna methyltransferase COG0566 Cluster_710738 V1002049 ACYP map00620,map00627,map01120 C Acylphosphatase COG1254 Cluster_446529 V1002050 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) COG0706 Cluster_189700 V1002051 SP_2145 G Alpha-1,2-mannosidase COG3537 Cluster_179317 V1002052 map02010 V ABC transporter COG1132 Cluster_179318 V1002053 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_698453 V1002054 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_747301 V1002055 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_506612 V1002056 RPSE map03010 J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) COG0098 Cluster_180152 V1002057 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_180153 V1002058 BGAA map00040,map00052,map00500,map00511,map00531,map00600,map00860,map00944,map00983,map01100,map04142 G hydrolase family 2, sugar binding COG3250 Cluster_180999 V1002061 CAPA M Capsule synthesis protein COG2843 Cluster_408414 V1002062 AHPC O alkyl hydroperoxide reductase COG0450 Cluster_475198 V1002063 AHPD S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) COG2128 Cluster_195959 V1002064 S Membrane 0Y3RG Cluster_477421 V1002065 YXKA S phospholipid-binding protein COG1881 Cluster_214765 V1002070 METE map00270,map00450,map01100,map01110,map01230 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) COG0620 Cluster_343788 V1002076 METF map00670,map00720,map01100,map01120 E Methylenetetrahydrofolate reductase COG0685 Cluster_327248 V1002077 YVFS map02010 V ABC transporter COG0842 Cluster_664450 V1002078 YVFR map02010 V ABC transporter COG1131 Cluster_366648 V1002079 DEGU map02020 T Two component transcriptional regulator luxr family COG2197 Cluster_668776 V1002080 YPSA S UPF0398 protein COG4474 Cluster_628131 V1002081 GPSB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) COG3599 Cluster_187155 V1002082 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_308983 V1002084 RPSB map03010 J 30S ribosomal protein S2 COG0052 Cluster_217073 V1002086 TAUA map02010 P ABC transporter substrate-binding protein COG0715 Cluster_434417 V1002087 P Chloride channel COG0038 Cluster_602261 V1002088 RPLS map03010 J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) COG0335 Cluster_572378 V1002092 CKL_1904 S YopX protein 0XUQJ Cluster_188856 V1002093 CLPL O ATP-dependent Clp protease ATP-binding subunit COG0542 Cluster_189701 V1002094 GATA map00970,map01100 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) COG0154 Cluster_682096 V1002095 OCAR_6878 map00281,map01110 C acyl-Coa dehydrogenase 0ZM68 Cluster_456449 V1002096 SRPF S NA 11IBX Cluster_227508 V1002097 MANA map00051,map00520,map01100,map01110 G mannose-6-phosphate isomerase COG1482 Cluster_501690 V1002098 MALA S maltodextrose utilization protein MalA COG5521 Cluster_421109 V1002099 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_548210 V1002100 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_664451 V1002101 S NA 12BEE Cluster_392563 V1002102 L C-5 cytosine-specific DNA methylase 0YDMD Cluster_192407 V1002105 NHAP P Na H antiporter COG0025 Cluster_631872 V1002106 map00230 S phosphorylase 11F11 Cluster_336241 V1002107 SP_0483 map02010 P ABC transporter COG1122 Cluster_591778 V1002108 S NA 0ZHU9 Cluster_740638 V1002109 PURS map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG1828 Cluster_378430 V1002110 S NA 0XPQF Cluster_368277 V1002111 YLME F alanine racemase domain protein COG0325 Cluster_591779 V1002112 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_525343 V1002114 V Vanz family COG4767 Cluster_598774 V1002115 K HTH_XRE 0XUC3 Cluster_197677 V1002117 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_827671 V1002118 RPMD map03010 J 50S ribosomal protein L30 COG1841 Cluster_195099 V1002119 PTSG map00010,map00500,map00520,map02060 G PTS system COG2190 Cluster_195960 V1002120 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_489010 V1002121 LYSA map00260,map00270,map00300,map00330,map00480,map01100,map01110,map01120,map01230 E diaminopimelate decarboxylase COG0019 Cluster_212479 V1002122 S NA 0ZMA4 Cluster_351714 V1002123 M n-acetylmuramoyl-l-alanine amidase 11R58 Cluster_199655 V1002127 S NA 0YA5W Cluster_199656 V1002129 LYSS map00970 J lysyL-tRNA synthetase COG2898 Cluster_273441 V1002131 TREC map00052,map00500,map01100 G trehalose-6-phosphate hydrolase (EC 3.2.1.93) COG0366 Cluster_595174 V1002133 ILVD map00290,map00770,map01100,map01110,map01210,map01230 E Dihydroxy-acid dehydratase COG0129 Cluster_272072 V1002134 MGTA P magnesium-translocating p-type atpase COG0474 Cluster_454509 V1002135 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0302 Cluster_475199 V1002136 FOLE map00790,map01100 H GTP cyclohydrolase i COG0302 Cluster_887097 V1002137 BMUL_0468 S ycii-related COG2350 Cluster_548211 V1002138 YJDF S Protein of unknown function (DUF2992) 11PXB Cluster_743860 V1002139 BL02849 S Baat aCyl-coa thioester hydrolase COG1073 Cluster_698454 V1002140 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_475200 V1002141 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_533712 V1002142 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_440481 V1002143 AROG map00400,map01100,map01110,map01230 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) COG0722 Cluster_363202 V1002144 S VTC domain protein 11IRS Cluster_605877 V1002145 S NA 0ZW6I Cluster_473071 V1002146 BMUL_0473 S ABC transporter, permease COG4120 Cluster_458355 V1002147 S abc transporter atp-binding protein COG1101 Cluster_205885 V1002148 NHAA map00680 P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) COG3004 Cluster_205886 V1002149 D ftsk spoIIIe COG1674 Cluster_525344 V1002150 SUFS map00450,map00730,map01100 E Cysteine desulfurase COG0520 Cluster_528182 V1002151 NIFU C SUF system FeS assembly protein, NifU family COG0822 Cluster_747302 V1002153 AGRA map02020 T response regulator COG3279 Cluster_319621 V1002154 COMD map02020 T Histidine kinase COG2972 Cluster_812146 V1002155 YYZM S protein, conserved in bacteria COG4481 Cluster_499138 V1002156 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_643820 V1002158 HUTG map00330,map00340,map01100 E formiminoglutamate hydrolase COG0010 Cluster_417531 V1002159 HUTH map00340,map01100 E Histidine ammonia-lyase COG2986 Cluster_209170 V1002160 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_353405 V1002161 SP_1914 S Cell wall-active antibiotics response protein (DUF2154) 11V5T Cluster_209171 V1002162 S NA 0YA5W Cluster_210271 V1002165 MALX map02010 G extracellular solute-binding protein family 1 COG2182 Cluster_605878 V1002167 MURE map00300,map00550,map01100 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_432531 V1002168 SP_1529 M Polysaccharide Biosynthesis Protein COG2244 Cluster_300515 V1002169 DLTA map00473,map05150 H Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) COG1020 Cluster_211362 V1002170 CDR P pyridine nucleotide-disulfide oxidoreductase COG0607 Cluster_277425 V1002171 USP S CHAP domain protein COG3942 Cluster_408415 V1002173 L 5'-3' exonuclease COG0749 Cluster_647837 V1002174 L Resolvase COG1961 Cluster_268090 V1002178 L Replication Protein COG5655 Cluster_213574 V1002181 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_396173 V1002185 YQEH S ribosome biogenesis GTPase YqeH COG1161 Cluster_581907 V1002186 YQEG V had superfamily (subfamily IIIa) phosphatase COG2179 Cluster_214766 V1002187 PEPX E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) 0XPUZ Cluster_496489 V1002188 RPSG map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) COG0049 Cluster_509240 V1002189 RPSL map03010 J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) COG0048 Cluster_270775 V1002190 SSTT E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) COG3633 Cluster_385454 V1002191 PERMEASE S permease COG0701 Cluster_602262 V1002192 YCGQ S transporter substrate-binding protein COG3689 Cluster_248790 V1002193 CORA P transporter COG0598 Cluster_215910 V1002194 map00860,map01100,map01110 S decarboxylase 11UPA Cluster_285607 V1002195 ECSB U (ABC) transporter COG4473 Cluster_850759 V1002196 ECSA V abc transporter atp-binding protein COG1131 Cluster_217074 V1002197 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_417532 V1002199 S Membrane COG4485 Cluster_378431 V1002200 map00564,map01100 I PAP2 Family COG0671 Cluster_423004 V1021801 M domain protein COG4932 Cluster_337798 V1021805 LPTB map02010 S ABC transporter COG1137 Cluster_562965 V1021806 S Protein of unknown function (DUF1573) 120RE Cluster_364937 V1021807 RV1337 S Rhomboid family COG0705 Cluster_325728 V1021808 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_647919 V1021810 YPJD S MazG nucleotide pyrophosphohydrolase COG1694 Cluster_157646 V1021817 M peptidase M23 0XQC5 Cluster_142650 V1021819 LIPA map00561,map01100 S Triacylglycerol lipase COG1075 Cluster_473122 V1021820 ARGR K Regulates arginine biosynthesis genes (By similarity) COG1438 Cluster_403188 V1021822 L Resolvase, N terminal domain COG1961 Cluster_284220 V1021825 N Cell surface protein 0XQ7Y Cluster_143345 V1021829 ZNTA P p-type atpase COG2217 Cluster_143346 V1021830 U, W Pfam:YadA COG5295 Cluster_620750 V1021831 E, G Membrane COG0697 Cluster_171002 V1021832 WECB map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_170172 V1021833 AMIB map00360 E amidohydrolase COG1473 Cluster_171808 V1021834 SSCG_04455 S Methyltransferase 0XSGP Cluster_530986 V1021835 S NA 0YXHR Cluster_325729 V1021836 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_772719 V1021837 S NA 11EM6 Cluster_613268 V1021838 S NA 11YJ3 Cluster_489069 V1021839 RLMH S Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) COG1576 Cluster_219435 V1021841 MANA map00051,map00520,map01100,map01110 G mannose-6-phosphate isomerase COG1482 Cluster_854694 V1021842 PNUC H nicotinamide mononucleotide transporter COG3201 Cluster_698512 V1021846 PGN_0051 S NA 0YP2S Cluster_792159 V1021847 S NA 0XNWW Cluster_368317 V1021850 YUGP S zinc metallopeptidase COG2738 Cluster_145580 V1021855 TPAU_0274 L transposase COG3547 Cluster_436505 V1021857 AZL_008490 L DNA methylase COG0863 Cluster_539529 V1021858 S NA 0YZDB Cluster_174365 V1021859 TELA P Resistance protein COG3853 Cluster_209201 V1021862 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E brancheD-chain amino acid aminotransferase COG0115 Cluster_242285 V1021867 RPOD map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_307655 V1021868 S NA 11EHP Cluster_222943 V1021869 M Glycosyl transferase, family 2 COG0463 Cluster_192443 V1021872 L site-specific recombinase, phage integrase family 11HGP Cluster_369974 V1021873 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_631962 V1021883 M efflux transporter, rnd family, mfp subunit COG0845 Cluster_151883 V1021884 M domain protein COG4932 Cluster_336281 V1021885 LMRA V ABC transporter, ATP-binding protein COG1132 Cluster_346976 V1021886 HEMG map00860,map01100,map01110 H protoporphyrinogen oxidase COG1232 Cluster_598853 V1021888 RPLN map03010 J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) COG0093 Cluster_737195 V1021889 RPSQ map03010 J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal COG0186 Cluster_605941 V1021891 FKPA O peptidylprolyl cis-trans isomerase COG0545 Cluster_188873 V1021892 RECQ map03018 L ATP-dependent DNA helicase RecQ COG0514 Cluster_217108 V1021894 LDH map00010,map00270,map00620,map00640,map01100,map01110,map01120 C lactate/malate dehydrogenase, alpha/beta C-terminal domain COG0039 Cluster_850830 V1021895 MT1293 map00350,map00362,map00627,map00642,map00903,map01120 I Acyl-transferase COG1835 Cluster_218222 V1021897 METN map02010 P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COG1135 Cluster_181021 V1021898 L Site-specific recombinase, phage integrase family 11F8N Cluster_228720 V1021900 TYRA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydrogenase COG0287 Cluster_345419 V1021903 S domain protein 1009W Cluster_707773 V1021906 RPSO map03010 J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) COG0184 Cluster_195974 V1021907 FBA map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01230 G fructose-bisphosphate aldolase COG0191 Cluster_430577 V1021908 EFP J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) COG0231 Cluster_517242 V1021909 S Thioesterase 11QVX Cluster_394344 V1021911 S Cytidylate kinase 0XP28 Cluster_158518 V1021912 S NA 0Y9QN Cluster_155969 V1021915 ILVC map00290,map00770,map01100,map01110,map01210,map01230 E Alpha-keto-beta-hydroxylacyl reductoisomerase COG0059 Cluster_605942 V1021917 S NA 0ZHU9 Cluster_292371 V1021918 MANY map00051,map00520,map01100,map02060 G PTS System COG3715 Cluster_183647 V1021921 PNTB map00760,map01100 C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) COG1282 Cluster_843164 V1021923 S NA 0ZHU9 Cluster_149443 V1021929 Y1701 map05133 U Inherit from COG: filamentous hemagglutinin family outer membrane protein COG3210 Cluster_162739 V1021930 S NA 0XPM9 Cluster_397952 V1021934 S NA 11KNZ Cluster_282846 V1021936 NOC K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) COG1475 Cluster_458405 V1021937 map00130 S nad(p)h dehydrogenase (quinone) COG2249 Cluster_158519 V1021940 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_838992 V1021945 MRDA map00550 M Penicillin-binding protein 2 COG0768 Cluster_470994 V1021946 MRED S Rod shape-determining protein MreD 1267M Cluster_318126 V1021950 S NA 12BX3 Cluster_494049 V1021953 STHE_0097 S doxx family COG2259 Cluster_313425 V1021954 COBM map00860,map01100 H precorrin-4 C(11)-methyltransferase COG2875 Cluster_276147 V1021955 SOJ D Chromosome Partitioning Protein COG1192 Cluster_486781 V1021958 SIGH K rna polymerase sigma factor COG1595 Cluster_539530 V1021960 S NA 0XXJW Cluster_509300 V1021961 S NA 124KR Cluster_151884 V1021962 UVRA map03420 L excinuclease ABC subunit A COG0178 Cluster_380175 V1021963 CICA E HAD-superfamily subfamily IB hydrolase COG0560 Cluster_151885 V1021968 GLNS map00970,map01100 J glutaminyL-tRNA synthetase COG0008 Cluster_284221 V1021970 C radical SAM domain protein COG0731 Cluster_780095 V1021972 S NA 0ZHU9 Cluster_668868 V1021975 ORF010 S Staphylococcal protein of unknown function (DUF960) 1265C Cluster_468888 V1021976 CCU S Protein of unknown function (DUF1643) COG4333 Cluster_181867 V1021977 MT0425 S secreted protein 10SG5 Cluster_152738 V1021980 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_578762 V1021981 S Conserved Protein COG1556 Cluster_291046 V1021982 BMUL_5818 C Iron-sulfur cluster binding protein COG1139 Cluster_701613 V1021983 YEAZ O Peptidase M22 Glycoprotease COG1214 Cluster_333242 V1021984 map00790,map01100 H Pterin binding enzyme COG0294 Cluster_501737 V1021985 FMT S decarboxylase family COG1611 Cluster_339282 V1021990 S NA 0YDZN Cluster_827723 V1021991 L Pfam:Transposase_11 0YB49 Cluster_277460 V1021993 P tonB-dependent Receptor 0XNN9 Cluster_545241 V1021994 S NA 0YIEB Cluster_788393 V1021996 PGN_0048 S NA 0YI97 Cluster_444557 V1021997 L Integrase 0YTFQ Cluster_156952 V1219801 SPSC map00362,map00363,map00520,map00626,map00650,map00903,map01100,map01110,map01120,map02020 M Polysaccharide biosynthesis protein COG0399 Cluster_534409 V1219802 LDB1085 S NA 0YWIA Cluster_326028 V1219803 map00230 S phosphorylase 11F11 Cluster_303666 V1219804 RSMI G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 Cluster_378831 V1219805 YABB map00340,map00350,map00624,map01120 L Methyltransferase COG4123 Cluster_53047 V1219806 COBN map00860,map01100 H cobaltochelatase, cobn subunit COG1429 Cluster_400000 V1219808 MT2477 S PemK-like protein 11VAX Cluster_467197 V1219809 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_65104 V1219810 FADD map00071,map01100,map03320,map04146,map04920 I Long-chain-fatty-acid--CoA ligase COG1022 Cluster_403569 V1219812 PDXP G hydrolase COG0647 Cluster_279065 V1219813 RRMJ J Hemolysin A COG1189 Cluster_497109 V1219814 FABT K Transcriptional regulator, MarR family 11N9R Cluster_225509 V1219815 FABH map00061,map01100 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) COG0332 Cluster_232431 V1219816 S AIPR protein 0ZFWF Cluster_203972 V1219818 GLGA map00500,map01100,map01110 G glycogen) synthase COG0438 Cluster_54534 V1219819 EMBC M Arabinosyltransferase 0XSQE Cluster_392957 V1219820 TILS D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) COG0037 Cluster_430964 V1219821 S phospholipase COG4667 Cluster_542998 V1219822 S Domain of unknown function (DUF1896) 0YBI2 Cluster_554762 V1219823 THIC map00730,map01100 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) COG0422 Cluster_738008 V1219828 ELAA S gCN5-related N-acetyltransferase COG2153 Cluster_104001 V1219829 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_711584 V1219830 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_67890 V1219831 YXCA I coA-substrate-specific enzyme activase COG3581 Cluster_120620 V1219833 S NA 0Z0R9 Cluster_554763 V1219834 LEBU_0481 L Transposase COG1943 Cluster_131124 V1219835 BCOA_0505 L transposase COG0675 Cluster_82122 V1219836 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_335050 V1219837 Q Methyltransferase Type COG0500 Cluster_458861 V1219838 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_61275 V1219840 TRAA L TrwC relaxase COG0507 Cluster_216131 V1219845 LIAG map02020 S Inherit from NOG: Membrane 0XV6C Cluster_114204 V1219846 S Iron transport-associated domain protein 0Y3IT Cluster_261674 V1219847 METN map02010 P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COG1135 Cluster_913203 V1219848 AARI_34870 L transposase of ISAar22, IS481 family COG2801 Cluster_124098 V1219849 GBRO_0040 L Transposase COG3464 Cluster_657043 V1219851 S NA 0XVGU Cluster_138242 V1219852 NATB C, P ABC transporter, permease COG1668 Cluster_114205 V1219853 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG1754 Cluster_384105 V1219854 PPM1 map00510,map01100 M dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) 0XQRC Cluster_171970 V1219855 LNT M Transfers the fatty acyl group on membrane lipoproteins (By similarity) COG0815 Cluster_254001 V1219857 STSB P Binding-protein-dependent transport systems, inner membrane component COG0601 Cluster_305173 V1219858 SCLAV_2693 P Binding-protein-dependent transport systems, inner membrane component 11V45 Cluster_237295 V1219859 CBPA O DnaJ domain protein COG2214 Cluster_421516 V1219861 CARD K Transcriptional regulator (CarD family COG1329 Cluster_339553 V1219862 ISPD map00900,map01100,map01110 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COG1211 Cluster_515154 V1219864 SP_1730 S Membrane COG3610 Cluster_171971 V1219865 HEMZ map00860,map01100,map01110 H coproporphyrinogen III oxidase COG0635 Cluster_228943 V1219867 AARI_34870 L transposase of ISAar22, IS481 family COG2801 Cluster_122156 V1219869 S NA 0ZX1V Cluster_499772 V1219870 S Domain of unknown function (DUF2088) COG3875 Cluster_59075 V1219871 S Rib/alpha-like repeat 10008 Cluster_216132 V1219872 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit delta' COG1466 Cluster_702263 V1219873 RES V Type III COG3587 Cluster_105808 V1219874 L ATP-dependent endonuclease of the OLD COG3593 Cluster_239884 V1219875 RBSC map02010 G Ribose transport system permease protein RbsC COG1172 Cluster_211612 V1219877 M Cell wall anchor domain protein 11PS2 Cluster_592616 V1219879 S Domain of unknown function (DUF3560) 100XC Cluster_294026 V1219882 K anti-repressor COG3645 Cluster_569978 V1219883 YAAT S psp1 domain protein COG1774 Cluster_324529 V1219884 S NA 0YFZU Cluster_357088 V1219885 YDFK S Membrane COG1811 Cluster_484989 V1219886 SGLY_0535 S phage protein 16PS0@proNOG Cluster_465118 V1219887 K NA 0YWD9 Cluster_542999 V1219888 COBC map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01230 H phosphatase COG0406 Cluster_345744 V1219889 TNP L transposase COG3316 Cluster_226630 V1219890 C alcohol dehydrogenase COG0604 Cluster_758489 V1219891 PGSA1 map00562,map00564,map01100,map04070 I Cdp-alcohol phosphatidyltransferase COG0558 Cluster_255207 V1219892 HTRB map00540,map01100 M lipid a biosynthesis lauroyl acyltransferase COG1560 Cluster_423375 V1219893 PIMA M Glycosyl transferase (Group 1 COG0438 Cluster_384106 V1219895 YQFA S hemolysin iii COG1272 Cluster_738011 V1219896 M (sortase) family COG3764 Cluster_285927 V1219897 CYDC map02010 P ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC COG1132 Cluster_563699 V1219900 S Pfam:DUF1696 11UJ8 Cluster_197894 V1219902 GRDB S Selenoprotein B, glycine betaine sarcosine D-proline reductase family 0XPCF Cluster_669758 V1219903 G Major Facilitator 0XPHU Cluster_517827 V1219904 map00440,map01110 M N-acetyltransferase COG1247 Cluster_140510 V1219905 SHC P drug resistance transporter, EmrB QacA subfamily 0XNN3 Cluster_342528 V1219906 TNP L transposase COG3316 Cluster_294027 V1219907 APHA J Aminoglycoside COG3231 Cluster_62086 V1219908 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_531629 V1219909 COBU map00860,map01100 H Adenosylcobinamide kinase COG2087 Cluster_318430 V1219910 S integral membrane protein 11MQQ Cluster_268392 V1219912 RBSA map02010 G ABC transporter COG1129 Cluster_156953 V1219917 S Inherit from NOG: peptidase inhibitor activity 0XX92 Cluster_62633 V1219918 LKTB3 V ABC transporter, ATP-binding protein COG2274 Cluster_687561 V1219919 BCOA_0505 L transposase COG0675 Cluster_252745 V1219920 TOPB L Dna topoisomerase COG0550 Cluster_324530 V1219923 S NA 12A8X Cluster_636891 V1219924 S Uncharacterized BCR, YitT family COG1284 COG1284 Cluster_102255 V1219925 YBIT S ABC transporter COG0488 Cluster_218465 V1219928 G Exopolysaccharide biosynthesis protein COG4632 Cluster_249050 V1219931 PFLX S radical SAM domain protein COG1313 Cluster_287334 V1219932 NADE map00760,map01100 H nh(3)-dependent nad( ) synthetase COG0171 Cluster_699183 V1219934 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_63462 V1219935 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_859531 V1219936 S NA 11WI9 Cluster_189024 V1219938 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG0582 Cluster_475731 V1219940 PDXS map00750 H Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) COG0214 Cluster_563700 V1219941 MT2684 L nudix hydrolase COG0494 Cluster_303667 V1219942 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_144217 V1219944 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_233699 V1219945 S Hydrid cluster protein-associated redox disulfide domain protein 123UM Cluster_358760 V1219946 S radical SAM domain protein 11FK0 Cluster_255208 V1219948 CORA P magnesium and cobalt transport protein CorA COG0598 Cluster_382333 V1219949 RIBD2 H bifunctional deaminase-reductase domain protein COG1985 Cluster_563701 V1219950 S Radical SAM superfamily COG0641 Cluster_599613 V1219951 AROQ map00400,map01100,map01110,map01230 E Catalyzes a trans-dehydration via an enolate intermediate (By similarity) COG0757 Cluster_196150 V1219952 AROB map00400,map01100,map01110,map01230 E 3-dehydroquinate synthase COG0337 Cluster_721532 V1219953 YAAK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) COG0718 Cluster_152048 V1219954 AARI_34710 L Transposase for insertion sequence 11IYJ Cluster_312253 V1219955 LGT M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 Cluster_318431 V1219956 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_454958 V1219960 LEPB map03060 U Signal peptidase i COG0681 Cluster_203973 V1219961 G Major Facilitator 0XPHU Cluster_515156 V1219962 K MarR family Transcriptional regulator 0Y4KW Cluster_509872 V1219965 ASP23 S alkaline shock protein COG1302 Cluster_276398 V1219966 SSCG_06117 S degv family COG1307 Cluster_94691 V1219967 THID map00730,map01100 H phosphomethylpyrimidine kinase COG0819 Cluster_360424 V1219968 SSCG_03030 map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_112765 V1219969 DACA map00550,map01100 M carboxypeptidase COG1686 Cluster_176131 V1219975 TRAA L TrwC relaxase COG0507 Cluster_322957 V1219976 LGT M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 Cluster_751512 V1219977 K Inherit from COG: Transcriptional regulator COG3655 Cluster_153654 V1219978 P Chloride channel COG0038 Cluster_800891 V1219979 BMUL_2943 G Major Facilitator Superfamily 0XNST Cluster_243882 V1219980 P Pfam:C4dic_mal_tran COG1275 Cluster_480351 V1219981 LYSR K LysR family (Transcriptional regulator COG0583 Cluster_543000 V1219982 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_507286 V1219984 ARGJ map00330,map01100,map01110,map01210,map01230 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) COG1364 Cluster_80971 V1219985 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_621535 V1219986 MT3093 E amino acid-binding act 0ZHQE Cluster_177789 V1219987 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_407063 V1219988 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_355399 V1219989 RSMG M Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) COG0357 Cluster_71825 V1219990 ACTP E sodium solute COG4147 Cluster_589251 V1219991 map02020,map03070 U Prokaryotic N-terminal methylation motif 0ZR0Y Cluster_442966 V1219994 S NA 11XN9 Cluster_705348 V1219995 S NA 0ZX1V Cluster_272379 V1219996 SP_1681 G ABC transporter (Permease COG0395 Cluster_313743 V1219998 CAFA map03018 J ribonuclease COG1530 Cluster_465119 V1219999 S NA 0ZS73 Cluster_292653 V1220000 DAPE map00300,map00330,map01100,map01110,map01120,map01210,map01230 E succinyl-diaminopimelate desuccinylase COG0624 Cluster_367012 V1220001 FMT S decarboxylase family COG1611 Cluster_489621 V1220002 C NADH dehydrogenase 12BDE Cluster_741431 V1220003 L Transposase 0ZX7U Cluster_256439 V1220004 MVAN_1091 L Integrase catalytic subunit COG2801 Cluster_661277 V1220005 MVAN_1090 L transposase, IS3 IS911 family protein 128FE Cluster_299463 V1220006 map02010 P Abc transporter COG1120 Cluster_68896 V1220007 L helicase domain protein COG0553 Cluster_147287 V1220008 S NA 0ZGFA Cluster_162046 V1220010 OCAR_7462 map00270,map00450,map01100,map01110,map01230 E Methionine synthase COG0620 Cluster_153655 V1220011 PRFC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) COG4108 Cluster_436945 V1220012 QCRC map00190,map01100 C cytochrome C COG2010 Cluster_412493 V1220013 CTAE map00190,map00910,map01100 C oxidase (Subunit III) COG1845 Cluster_430965 V1220014 AHPC O Peroxiredoxin COG0450 Cluster_252746 V1220015 COBL map00860,map01100 H Precorrin-6y C5,15-methyltransferase COG2242 Cluster_324531 V1220016 RV2073C I, Q short-chain dehydrogenase reductase COG1028 Cluster_250310 V1220017 LACC map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G tagatose-6-phosphate kinase COG1105 Cluster_284487 V1220018 S abc transporter permease protein 124X7 Cluster_268393 V1220019 ECFA2 map02010 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates COG1122 Cluster_319911 V1220020 THYX map00240,map00340,map00350,map00624,map00670,map01120 F Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) COG1351 Cluster_85914 V1220021 SPOIID D SpoIID LytB domain protein COG2385 Cluster_212696 V1220022 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily COG1368 Cluster_319912 V1220023 GLPQ map00564 C glycerophosphoryl diester phosphodiesterase COG4781 Cluster_545939 V1220024 GLPQ map00564 C glycerophosphoryl diester phosphodiesterase COG4781 Cluster_809136 V1220025 S Inherit from COG: conserved protein COG1434 Cluster_512454 V1220026 DTD J Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) COG1490 Cluster_851751 V1220027 S NA 0ZHU9 Cluster_268394 V1220029 S phospholipase COG4667 Cluster_142769 V1220030 S NA 125HN Cluster_423376 V1220032 S Phage-associated protein 11FS5 Cluster_196152 V1220034 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_144969 V1220035 DAPL map00300,map01100,map01110,map01230 H Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli (By similarity) COG0436 Cluster_310727 V1220039 HPRK T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) COG1493 Cluster_484990 V1220041 AMAA map00360 E amidohydrolase COG1473 Cluster_172878 V1220042 map00500,map01100,map04973 G alpha amylase, catalytic COG0366 Cluster_166881 V1220043 S NA 0ZS65 Cluster_102256 V1220045 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_425163 V1220046 UNG L uracil-dna glycosylase COG1573 Cluster_385871 V1220047 COBO map00860,map01100 H Cob-I-yrinic acid a,c-diamide adenosyltransferase COG2109 Cluster_247742 V1220048 COBB map00860,map01100 H Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) COG1797 Cluster_250311 V1220049 PAFB K Transcriptional regulator COG2378 Cluster_73856 V1220050 GBS0386 S domain protein 0XRRR Cluster_194420 V1220051 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_295438 V1220052 O DnaJ domain protein COG0484 Cluster_596098 V1220053 S domain protein 0Y8F3 Cluster_523153 V1220054 YTBE map00051,map00363,map00591,map00625,map00650,map01100,map01120 C reductase COG0656 Cluster_176132 V1220055 HISD map00340,map01100,map01110,map01230 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) COG0141 Cluster_419720 V1220056 YPRA L dEAD DEAH box helicase COG1205 Cluster_800892 V1220057 CSPA K Cold shock protein COG1278 Cluster_416142 V1220058 S dedA family COG0586 Cluster_452929 V1220059 NUDF map00230 F nudix hydrolase COG0494 Cluster_309283 V1220060 CSHA map03018 L ATP-dependent RNA helicase COG0513 Cluster_545940 V1220061 S Holin family 0YUUS Cluster_93747 V1220063 L transposase COG3666 Cluster_744744 V1220065 MJLS_1669 L transposase, IS3 IS911 family protein COG2963 Cluster_520375 V1220066 S DNA-binding helix-turn-helix protein 0ZJRR Cluster_277706 V1220069 S NA 12BX4 Cluster_385872 V1220072 COMEA L Competence protein COG1555 Cluster_124099 V1220076 MRCB map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_678600 V1220077 CAS2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) COG3512 Cluster_257725 V1220079 map05100 G s-layer domain protein 11IBF Cluster_202932 V1220081 U, W Pfam:YadA COG5295 Cluster_551899 V1220082 ATTT S acetyltransferase, (GNAT) family 11VF3 Cluster_76097 V1220083 S NA 0ZTYV Cluster_428992 V1220084 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_199890 V1220085 AMIDASE map00330,map00360,map00380,map00627,map00643,map01120 J Amidase COG0154 Cluster_484991 V1220087 GCVPB map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG1003 Cluster_528838 V1220088 DTD J Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) COG1490 Cluster_227765 V1220089 SCLAV_2537 J methyltransferase COG2890 Cluster_592617 V1220090 ARGR K Regulates arginine biosynthesis genes (By similarity) COG1438 Cluster_212697 V1220091 PRE S plasmid recombination enzyme 0XTDI Cluster_132646 V1220093 L Pfam:Transposase_11 0YB49 Cluster_196153 V1220094 HRCA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) COG1420 Cluster_115563 V1220095 M cell wall-binding protein COG2247 Cluster_741432 V1220099 MOAB2 H molybdenum cofactor biosynthesis protein COG0521 Cluster_540121 V1220101 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_392959 V1220102 MT1019 S saf domain-containing protein 122V5 Cluster_731461 V1220108 K Transcriptional Regulator AraC Family 0ZYR5 Cluster_210471 V1220112 YLOV S dak2 domain fusion protein ylov COG1461 Cluster_191665 V1220113 MEND map00130,map01100,map01110 H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) COG1165 Cluster_471487 V1220114 MENB map00130,map01100,map01110 H Naphthoate synthase COG0447 Cluster_394770 V1220117 ATPD map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG1394 Cluster_85538 V1220118 S Ragb susd domain-containing protein 0XPXH Cluster_410679 V1220120 D plasmid partition protein ParA COG1192 Cluster_644784 V1220122 ETFA map00910 C electron transfer flavoprotein alpha subunit COG2025 Cluster_275065 V1220123 LPXC map00061,map00540,map01100 M involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) COG0774 Cluster_168530 V1220126 S NA 11F3W Cluster_469338 V1220132 CCPA K Transcriptional regulator, LacI family COG1609 Cluster_279066 V1220134 REPA L Replication initiator protein A 0YDCP Cluster_592618 V1220136 map00540,map01100 S Phage-related protein 11PAV Cluster_102257 V1220137 S surface protein 11NE4 Cluster_341009 V1220138 E Peptidase family S51 11R1E Cluster_540122 V1220140 TCSR3 T regulatoR COG2197 Cluster_836128 V1220143 S Inherit from COG: oxidoreductase 0XPNK Cluster_259045 V1220144 M Sortase family COG3764 Cluster_122829 V1220146 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_82123 V1220147 PHOA map00521,map00627,map00790,map01100,map01110,map01120,map02020 P alkaline phosphatase COG1785 Cluster_371954 V1220150 COBD map00860,map01100 H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) COG1270 Cluster_112766 V1220151 SELB map00450,map00970 J Selenocysteine-specific translation elongation factor COG3276 Cluster_758491 V1220152 XSEB map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) 0ZZ01 Cluster_294028 V1220153 ISPA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_718203 V1220154 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_83395 V1220155 TRAA L TrwC relaxase COG0507 Cluster_589252 V1220159 DPRA L DNA protecting protein DprA COG0758 Cluster_392960 V1220160 S NA 11Y61 Cluster_371955 V1220161 BCELL_1025 L Transposase COG2801 Cluster_440952 V1220162 L Transposase 11X46 Cluster_300832 V1220163 BL00144 L Transposase COG2801 Cluster_380561 V1220164 L Transposase COG0675 Cluster_342530 V1220165 NLAXM map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_313744 V1220166 GLNQ E ABC transporter, ATP-binding protein COG1126 Cluster_385873 V1220167 SSCG_01435 E ABC transporter COG0765 Cluster_84713 V1220168 ELI_1307 M phage tail tape measure protein COG5283 Cluster_124753 V1220169 YJCE P Na H antiporter COG0025 Cluster_344118 V1220170 GLNQ map02010 E abc transporter atp-binding protein COG1126 Cluster_131894 V1220172 O phage portal protein HK97 family COG4695 Cluster_342531 V1220173 S Pfam:DUF322 0XUSX Cluster_454959 V1220174 S alkaline shock protein COG1302 Cluster_177790 V1220175 L DNA primase catalytic core domain protein COG0358 Cluster_86379 V1220178 SURB S G5 domain protein 0ZVV3 Cluster_515157 V1220179 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_692091 V1220180 S NA 0ZHU9 Cluster_327592 V1220181 SCLAV_1351 M Secreted protein COG0791 Cluster_557682 V1220182 CG2401 M Secreted protein COG0791 Cluster_436946 V1220183 ISPG map00900,map01100,map01110 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) COG0821 Cluster_636893 V1220184 ARSB P arsenicaL-resistance protein COG0798 Cluster_621536 V1220185 K Sugar-specific transcriptional regulator TrmB COG0640 Cluster_480352 V1220186 YDFG map00362,map01100,map01120 S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) COG2128 Cluster_344119 V1220189 S host cell surface-exposed lipoprotein 11S42 Cluster_86380 V1220190 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_446990 V1220191 ENTB Q Isochorismatase, hydrolase 11I3F Cluster_475732 V1220192 HEMN map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_832238 V1220198 S Suppressor of fused protein (SUFU) 11QEC Cluster_489622 V1220199 FUR K regulator Fur family COG0735 Cluster_166882 V1220202 FIC D cell filamentation protein COG2184 Cluster_338122 V1220204 L transposase 11GFI Cluster_487264 V1220205 HP1080 V restriction endonuclease COG1787 Cluster_531631 V1220206 S Membrane 12424 Cluster_196154 V1220207 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_489623 V1220208 V type I restriction modification DNA specificity domain COG0732 Cluster_201881 V1220209 HSDM-1 V Type I restriction-modification system, M subunit COG0286 Cluster_172879 V1220211 PRPE map00230 T Phosphatase COG4639 Cluster_758492 V1220213 NOCA_0571 L transposase COG2963 Cluster_247743 V1220214 TNPB L integrase catalytic COG2801 Cluster_327593 V1220215 S Inherit from COG: Alpha beta hydrolase COG0596 Cluster_389415 V1220216 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_665452 V1220218 S Protein of unknown function (DUF2516) 0XXPZ Cluster_333544 V1220219 S NA 12A0N Cluster_94692 V1220220 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_89975 V1220221 U TraG family COG3505 Cluster_335051 V1220222 IOLTB G ABC transporter COG1172 Cluster_371956 V1220223 IOLTC G ABC transporter COG1129 Cluster_90425 V1220224 M domain protein COG4932 Cluster_291296 V1220225 ZWF map00030,map00480,map01100,map01110,map01120 G glucose-6-phosphate 1-dehydrogenase COG0364 Cluster_871826 V1220226 ZWF map00030,map00480,map01100,map01110,map01120 G glucose-6-phosphate 1-dehydrogenase COG0364 Cluster_840000 V1220227 SDHA map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020,map05134 C succinate dehydrogenase, flavoprotein subunit COG1053 Cluster_326029 V1220228 SDHB map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120 C succinate dehydrogenase fumarate reductase iron-sulfur subunit COG0479 Cluster_396558 V1220230 RPSB map03010 J 30S ribosomal protein S2 COG0052 Cluster_382334 V1220231 map03022,map03420 L type iii restriction protein res subunit COG1061 Cluster_475733 V1220232 DPRE1 C FAD linked oxidase domain protein COG0277 Cluster_520376 V1220234 RV3789 S Membrane COG2246 Cluster_678601 V1220235 GLFT1 M Glycosyl transferase, family 2 COG1216 Cluster_289980 V1220236 SUFC O feS assembly ATPase SufC COG0396 Cluster_475734 V1220240 MT1505 map02010 V ABC transporter COG1131 Cluster_367013 V1220241 DARB map00061,map01100 I synthase III COG0332 Cluster_705349 V1220242 K Transcriptional regulator 1240D Cluster_151216 V1220243 G Major Facilitator superfamily 0XQFH Cluster_163685 V1220248 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_603180 V1220249 K Transcriptional regulator, ARAC family COG2207 Cluster_444946 V1220251 RHAT7 E, G Transporter COG0697 Cluster_269740 V1220252 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_405377 V1220253 XTHA map03410 L Exodeoxyribonuclease III COG0708 Cluster_384107 V1220254 LGT M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 Cluster_382335 V1220255 VEX2 V abc transporter atp-binding protein COG1136 Cluster_534411 V1220256 S HutP family 11NY2 Cluster_425164 V1220257 E amidohydrolase COG1473 Cluster_277707 V1220258 ABGT H Transporter COG2978 Cluster_178626 V1220259 MDLB map02010 V ABC transporter COG1132 Cluster_280370 V1220260 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG1754 Cluster_480353 V1220261 COBJ map00860,map01100 H Precorrin-3B C17-methyltransferase COG2243 Cluster_436947 V1220262 CLOSA_0730 V Hnh endonuclease COG1479 Cluster_277708 V1220263 O SPFH domain / Band 7 family COG0330 Cluster_520378 V1220264 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_391145 V1220265 MUTT L hydrolase COG0494 Cluster_168531 V1220266 PARE L DNA topoisomerase IV (Subunit B) COG0187 Cluster_554765 V1220267 SP_2057 I Acyl-transferase COG1835 Cluster_471488 V1220268 GYAR map00260,map00630,map00680,map01100,map01120,map01230 C D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding COG1052 Cluster_430966 V1220270 S NA 1243K Cluster_303668 V1220273 S Membrane COG2966 Cluster_260350 V1220277 LEUB map00290,map01100,map01110,map01210,map01230 E Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) COG0473 Cluster_135066 V1220278 ARGH map00250,map00330,map01100,map01110,map01230 E arginosuccinase COG0165 Cluster_97358 V1220279 YHGE S domain protein COG1511 Cluster_473598 V1220280 PAFA1 S proteasome 0XQPS Cluster_657045 V1220281 FTHC map00670,map01100 H 5-formyltetrahydrofolate cyclo-ligase COG0212 Cluster_223157 V1220282 GALU map00040,map00052,map00500,map00520,map01100,map01110 M UTP-glucose-1-phosphate uridylyltransferase COG1210 Cluster_195301 V1220283 FUSA2 J Translation elongation factor COG0480 Cluster_566896 V1220284 BMUL_0473 S ABC transporter, permease COG4120 Cluster_573188 V1220288 RV2239C S Protein of unknown function (DUF3052) 11N74 Cluster_463031 V1220290 RESA2 O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG0526 Cluster_540123 V1220292 PS333 L terminase (Small subunit) COG3728 Cluster_526074 V1220293 BL00759 L Phage terminase, large subunit COG1783 Cluster_98964 V1220294 SURB S G5 domain protein 0ZVV3 Cluster_217335 V1220295 M Glycosyl transferase family 2 COG0463 Cluster_569979 V1220296 AMRA M polysaccharide biosynthesis protein COG2244 Cluster_99487 V1220299 SUCA map00020,map00310,map00380,map01100,map01110,map01120 C 2-oxoglutarate dehydrogenase, E1 COG0567 Cluster_107053 V1220300 S NA 11NI8 Cluster_303669 V1220301 S integral membrane protein COG3182 Cluster_644785 V1220302 MENB map00130,map00360,map01100,map01110,map01120 H Naphthoate synthase COG0447 Cluster_599614 V1220304 S NA 0ZHU9 Cluster_262971 V1220305 YICL E, G Transporter COG0697 Cluster_201882 V1220310 ORFL L transposase COG2826 Cluster_154455 V1220311 ASPC map00250,map00290,map01100,map01110,map01210,map01230 E Aminotransferase COG0436 Cluster_375286 V1220312 BMUL_5568 S nerd domain protein 0XSNF Cluster_357089 V1220313 S NA 1241G Cluster_101139 V1220314 HSDM V HsdM N-terminal domain COG0286 Cluster_239885 V1220317 PRSA O Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) COG0760 Cluster_475735 V1220319 LEPB map03060 U Signal peptidase i COG0681 Cluster_781093 V1220322 HUNADC P transporter COG0471 Cluster_523154 V1220323 SDRA V type iii restriction COG1061 Cluster_175337 V1220324 BAES map02020 T Histidine kinase COG0642 Cluster_157819 V1220326 S Inherit from NOG: S-layer protein 0ZUVU Cluster_102800 V1220327 HELY L helicase COG4581 Cluster_509873 V1220329 PROTEASE map05120 O peptidase, U32 COG0826 Cluster_444947 V1220331 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_442967 V1220333 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG3848 Cluster_417950 V1220335 L Replication Protein 0YRQ2 Cluster_614098 V1220337 S Protein of unknown function (DUF1232) COG3339 Cluster_255209 V1220338 RIHC map00230,map00240,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_230093 V1220339 WBPC I Acyl-transferase COG1835 Cluster_614099 V1220340 GLPG S Rhomboid family COG0705 Cluster_454961 V1220341 FTHC map00670,map01100 H 5-formyltetrahydrofolate cyclo-ligase COG0212 Cluster_106415 V1220344 U, W Inherit from COG: domain protein COG5295 Cluster_844070 V1220345 DAGA E amino acid carrier protein COG1115 Cluster_178627 V1220346 PGM map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase (EC 5.4.2.2 COG0033 Cluster_335052 V1220347 S NA 0XQDK Cluster_687563 V1220348 YLXQ J ribosomal protein COG1358 Cluster_131895 V1220349 GCVPA map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG0403 Cluster_126099 V1220351 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_353724 V1220352 T response regulator 11GEV Cluster_534413 V1220353 BCRA map02010 V ABC transporter COG1131 Cluster_162887 V1220355 V Mate efflux family protein COG0534 Cluster_197895 V1220356 HOM map00260,map00270,map00300,map01100,map01110,map01120,map01230 E homoserine dehydrogenase COG0460 Cluster_731463 V1220357 LYSA map00300,map01100,map01110,map01120,map01230 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) COG0019 Cluster_380563 V1220359 V abc transporter atp-binding protein COG1131 Cluster_295439 V1220360 map02010 P ABC transporter COG1122 Cluster_477941 V1220361 map00630,map01100,map01110 S haloacid dehalogenase-like hydrolase COG0546 Cluster_108797 V1220362 MURG map00550,map01100,map04112 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) COG0707 Cluster_840001 V1220363 HELY L helicase COG4581 Cluster_178628 V1220364 PEPP map00310,map00780,map01100 E peptidase M24 COG0006 Cluster_644786 V1220365 SPOU J rrna methyltransferase COG0566 Cluster_614100 V1220366 RPLT map03010 J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) COG0292 Cluster_805096 V1220367 RPMI map03010 J 50S ribosomal protein L35 COG0291 Cluster_487265 V1220368 INFC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) COG0290 Cluster_129614 V1220369 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_440953 V1220371 S NA 180SD@proNOG Cluster_515158 V1220373 SP_0341 S UPF0371 protein COG4868 Cluster_138989 V1220375 V FtsX-like permease family 0ZW5X Cluster_793012 V1220376 PEPTIDASE E prolyl oligopeptidase COG1505 Cluster_166144 V1220377 PEPN_1 E Peptidase M1 membrane alanine aminopeptidase COG0308 Cluster_186482 V1220378 CAT1 map00281,map00620,map00626,map01110,map01120 C Transferase COG0427 Cluster_178629 V1220379 CARA map00240,map00250,map01100 F carbamoyl-phosphate synthetase glutamine chain COG0505 Cluster_754964 V1220380 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_312254 V1220381 S copper amine 121X1 Cluster_705351 V1220383 S Protein of unknown function (DUF1778) COG4453 Cluster_465120 V1220384 K Gcn5-related n-acetyltransferase COG0454 Cluster_520379 V1220385 RPLM map03010 J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) COG0102 Cluster_432971 V1220386 RPSI map03010 J 30S ribosomal protein S9 COG0103 Cluster_173713 V1220388 S surface protein 11NE4 Cluster_347326 V1220389 SCPA S Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) COG1354 Cluster_256440 V1220390 map00330,map00360,map00380,map00627,map00643,map01120 C Acetamidase formamidase COG2421 Cluster_396559 V1220391 TERY_3118 L Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) COG0553 Cluster_358761 V1220392 MCTB S wide pore channel activity 0XPWI Cluster_113505 V1220395 MEXF V AcrB AcrD family multidrug resistance protein COG0841 Cluster_113506 V1220397 RES V Type III COG3587 Cluster_563703 V1220398 SPXA_1 K transcriptional regulator, Spx COG1393 Cluster_430967 V1220399 S NA 0YEA2 Cluster_322958 V1220400 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_114206 V1220401 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_796955 V1220402 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_151217 V1220404 MEND map00130,map01100,map01110 H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) COG1165 Cluster_114881 V1220405 S NA 0ZTYV Cluster_384108 V1220406 S single-strand binding family protein 0XS6K Cluster_724881 V1220408 PSTS map02010,map02020,map05152 P Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) COG0226 Cluster_221979 V1220409 PSTC map02010 P phosphate abc transporter COG0573 Cluster_216133 V1220411 ECHA3 map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120 I Enoyl-CoA hydratase COG1024 Cluster_504705 V1220413 MERR2 K merR family transcriptional Regulator COG0789 Cluster_762256 V1220415 D cobyrinic Acid a,c-diamide synthase COG1192 Cluster_724882 V1220416 MRR V restriction COG1715 Cluster_851754 V1220417 MRR V restriction COG1715 Cluster_463032 V1220418 RES V Type III COG3587 Cluster_178630 V1220422 AFTD S coagulation factor 5 8 type domain-containing protein 0YR9E Cluster_116290 V1220423 TOPB L Dna topoisomerase COG0550 Cluster_116291 V1220424 S NA 0ZTYV Cluster_187320 V1220425 PEPP map00310,map00780,map01100 E peptidase M24 COG0006 Cluster_195302 V1220427 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_504706 V1220428 SHP S Cell surface heme-binding protein Shp 12069 Cluster_551900 V1220430 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_342532 V1220432 L Replication initiator protein A 0Y2JJ Cluster_233700 V1220433 PEPD map02020 O Peptidase s1 and s6 chymotrypsin hap COG0265 Cluster_119127 V1220437 V type II restriction enzyme, methylase subunit COG1002 Cluster_119128 V1220438 TOPB L Dna topoisomerase COG0550 Cluster_509874 V1220441 MSRB O reductase COG0229 Cluster_380564 V1220444 L Helicase COG1061 Cluster_367014 V1220445 SCLAV_2473 S NA 0XZ8Y Cluster_724883 V1220446 RNPA J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) 124YT Cluster_154456 V1220448 L DNA polymerase 0XRUF Cluster_632865 V1220450 S NA 0ZHU9 Cluster_122157 V1220451 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_657046 V1220452 S NA 0YW62 Cluster_389416 V1220453 S had-superfamily hydrolase, subfamily ia, variant COG1011 Cluster_167682 V1220454 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_122830 V1220455 AMIA map02010 E Oligopeptide-binding protein COG4166 Cluster_162047 V1220456 CSD1 L CRISPR-associated protein Csd1 family 0ZVNC Cluster_269741 V1220458 DEGV S degv family COG1307 Cluster_363560 V1220459 S NA 0ZF15 Cluster_543001 V1220461 S NA 1119B Cluster_296779 V1220462 SP_1461 map02010 E abc transporter permease protein 11RN5 Cluster_143469 V1220463 PRTC map05120 O collagenase COG0826 Cluster_220813 V1220464 PARC L DNA topoisomerase IV, subunit A COG0188 Cluster_549000 V1220467 COBK map00860,map01100 H reductase COG2099 Cluster_265680 V1220472 RSGA G May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) COG1162 Cluster_731464 V1220473 YQEY S gatB Yqey COG1610 Cluster_832239 V1220474 RPSU map03010 J 30S ribosomal protein S21 COG0828 Cluster_487266 V1220475 ARGR K Regulates arginine biosynthesis genes (By similarity) COG1438 Cluster_661278 V1220476 PARE L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_221980 V1220478 PABB map00790 E synthase component I COG0147 Cluster_721535 V1220480 CYSE map00270,map00920,map01100,map01120,map01230 E serine acetyltransferase COG1045 Cluster_241158 V1220481 CYSK map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_134270 V1220482 map03440 K Transcriptional regulator COG2865 Cluster_217336 V1220483 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_432972 V1220484 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_312255 V1220487 MSHB S Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) COG2120 Cluster_796957 V1220489 FDXA C Ferredoxin COG1146 Cluster_182086 V1220493 RV0485 K Transcriptional regulator COG1940 Cluster_640924 V1220494 MT3734 S Uncharacterized conserved protein (DUF2304) 122QX Cluster_357090 V1220495 MT3733 map00510,map01100 M Glycosyl transferase COG0463 Cluster_708455 V1220496 LSGF map00051 M glycosyltransferase COG0463 Cluster_859535 V1220497 MCBR K Transcriptional regulator 11WG2 Cluster_731465 V1220498 S Transglycosylase associated protein 12BJA Cluster_358762 V1220499 USPA1 T Universal stress protein COG0589 Cluster_189884 V1220500 MRCB map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_465121 V1220501 S single-strand binding family protein 0XS6K Cluster_531632 V1220508 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_128182 V1220511 SUN_0728 L transposase (IS4 family) protein 12CNV Cluster_665453 V1220513 TRXA O Thioredoxin COG0526 Cluster_387717 V1220515 L Replication Protein 0YRQ2 Cluster_487267 V1220518 YBAK S YbaK ebsC protein COG2606 Cluster_128894 V1220519 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_416143 V1220521 K Peptidase S24-like protein COG2932 Cluster_551901 V1220522 RV2239C S Protein of unknown function (DUF3052) 11N74 Cluster_246483 V1220524 TYPA T gtp-binding protein typa COG1217 Cluster_687564 V1220525 MJLS_1669 L transposase, IS3 IS911 family protein COG2963 Cluster_316856 V1220526 AARI_35290 L integrase catalytic COG2801 Cluster_400001 V1220527 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_596099 V1220528 O serine protease 11GRH Cluster_271052 V1220531 RES V Type III COG3587 Cluster_360425 V1220534 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_683129 V1220535 J Elongation factor Tu GTP binding domain COG0050 Cluster_131125 V1220536 E Peptidase, S9A B C family, catalytic domain protein COG1506 Cluster_714960 V1220537 K Transcriptional regulator 0XUC3 Cluster_648841 V1220538 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_863867 V1220541 S NA 12BS1 Cluster_368623 V1220542 YVDE J Glutamine amidotransferase COG2071 Cluster_322960 V1220543 N, O, T adapter protein MecA COG4862 Cluster_731467 V1220544 LDB1874 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_326031 V1220546 L SNF2 family DNA RNA helicase COG0553 Cluster_442969 V1220547 map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_131896 V1220548 RES V Type III COG3587 Cluster_281712 V1220549 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_298182 V1220552 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0470 Cluster_449010 V1220554 S Gp157 family 11ZXY Cluster_370338 V1220557 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_380565 V1220558 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_265681 V1220560 LYTR1 K TRANSCRIPTIONal COG1316 Cluster_617873 V1220561 S NA 0ZHU9 Cluster_166883 V1220566 K Inherit from firmNOG: Transcriptional regulator COG2865 Cluster_534414 V1220569 S NA 17HPJ@proNOG Cluster_520380 V1220570 S NA 0YVRK Cluster_243883 V1220571 S NA 11JF2 Cluster_391146 V1220572 GLNQ E abc transporter atp-binding protein COG1126 Cluster_614101 V1220574 O Pentapeptide repeat protein COG1357 Cluster_480354 V1220578 DCP E oligopeptidase A COG0339 Cluster_333545 V1220581 map05100 S repeat protein 11TEE Cluster_603181 V1220582 VAPC S Toxic component of a toxin-antitoxin (TA) module. A COG1487 Cluster_255210 V1220584 RLUC J pseudouridine synthase COG0564 Cluster_249051 V1220586 ARDC L antirestriction protein COG4227 Cluster_875913 V1220588 S NA 11HVF Cluster_231269 V1220589 LACC map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G tagatose-6-phosphate kinase COG1105 Cluster_499773 V1220593 SARZ K Transcriptional regulator 11TPH Cluster_492120 V1220594 K Transcriptional regulator COG1959 Cluster_348942 V1220595 EBA2484 L AtP-binding protein COG1484 Cluster_138990 V1220597 MBTB map01053 Q non-ribosomal peptide synthetase COG1020 Cluster_652930 V1220598 LACF map00052,map01100,map02060 G PTS System COG1447 Cluster_563704 V1220603 CDPW8_0140 S Protein of unknown function (DUF3644) 11FC8 Cluster_606789 V1220604 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_227766 V1220605 SPPA O, U Signal peptide peptidase, SppA COG0616 Cluster_140511 V1220606 N, U Inherit from COG: flagellar rod assembly protein muramidase flgj COG1705 Cluster_387718 V1220608 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_875914 V1220609 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_249052 V1220610 NANH map00520 E, M N-acetylneuraminate lyase COG0329 Cluster_269742 V1220611 S doxx family COG2259 Cluster_523155 V1220612 E solute binding transport lipoprotein COG0747 Cluster_410681 V1220613 SCLAV_2829 S Sec-C motif domain protein 100MK Cluster_644788 V1220614 BCELL_1025 L Transposase COG2801 Cluster_371958 V1220615 C SNARE associated Golgi COG0398 Cluster_432973 V1220616 PARC L DNA topoisomerase IV, subunit A COG0188 Cluster_636895 V1220617 map03440 K Transcriptional regulator COG2865 Cluster_327594 V1220618 map03440 K Transcriptional regulator COG2865 Cluster_198891 V1220620 YABE M domain protein COG3584 Cluster_142770 V1220621 M domain protein COG4932 Cluster_341011 V1220622 MDH map00620,map00710,map01100,map01120,map02020 C malate dehydrogenase (Oxaloacetate-decarboxylating) COG0281 Cluster_560749 V1220623 PKND E ABC transporter substrate-binding protein COG0834 Cluster_692093 V1220626 RPSO map03010 J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) COG0184 Cluster_257726 V1220627 S NA 12B83 Cluster_143470 V1220628 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_196155 V1220632 SCLAV_2561 O serine protease COG0265 Cluster_144970 V1220633 map03420,map03430 L helicase COG3973 Cluster_307869 V1220634 S Extracellular solute-binding protein, family 5 0XQUV Cluster_517828 V1220635 P Binding-protein-dependent transport systems, inner membrane component COG0601 Cluster_766221 V1220636 L transposase COG3328 Cluster_636896 V1220637 TNP3504J L Transposase COG2801 Cluster_579516 V1220638 NDVA2 V ABC transporter, ATP-binding protein COG1132 Cluster_273714 V1220639 V ABC transporter COG1132 Cluster_576412 V1220641 S Radical SAM superfamily COG0641 Cluster_502306 V1220642 AMIB map00360 E amidohydrolase COG1473 Cluster_569980 V1220643 RPSI map03010 J 30S ribosomal protein S9 COG0103 Cluster_442970 V1220644 S Conserved domain protein 0XZV4 Cluster_315328 V1220647 K, L domain protein COG0553 Cluster_708457 V1220648 S VRR-NUC domain protein 122HE Cluster_234893 V1220649 T Histidine kinase COG0642 Cluster_266990 V1220650 PRKC T Serine threonine protein kinase COG0515 Cluster_146514 V1220651 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_738014 V1220652 S helix-turn-helix domain protein 122WR Cluster_592620 V1220655 S NA 11M8V Cluster_644789 V1220657 ILVN map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E Acetolactate synthase small subunit COG0440 Cluster_257727 V1220658 ILVB map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E acetolactate synthase COG0028 Cluster_592621 V1220659 MANO S ManO family COG4687 Cluster_321389 V1220660 EBA2484 L AtP-binding protein COG1484 Cluster_844071 V1220662 RPMB map03010 J 50S ribosomal protein l28 COG0227 Cluster_292654 V1220664 RPFB L domain protein COG3583 Cluster_307870 V1220665 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_585941 V1220666 COAA map00770,map01100 H pantothenic acid kinase COG1072 Cluster_610453 V1220667 GAP map00010,map01100,map01110,map01120,map01230,map04066,map05010 G Glyceraldehyde-3-phosphate dehydrogenase COG0057 Cluster_373573 V1220668 DEDA S dedA family COG0586 Cluster_341012 V1220669 SCPA S Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) COG1354 Cluster_423377 V1220670 PNCA map00760,map01100 Q nicotinamidase COG1335 Cluster_579517 V1220672 YGAI S Methyl-accepting chemotaxis family protein COG4768 Cluster_921460 V1220673 S Protein of unknown function (DUF1294) COG3326 Cluster_367016 V1220674 YLME F alanine racemase domain protein COG0325 Cluster_368626 V1220675 NPTA P Sodium-dependent phosphate COG1283 Cluster_487268 V1220676 MDLB V abc transporter COG1132 Cluster_721536 V1220678 DNAJ1 O DnaJ domain protein COG2214 Cluster_361992 V1220679 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_322961 V1220681 V abc transporter permease protein 0ZW5X Cluster_785219 V1220682 K Transcriptional regulator 0XUP9 Cluster_150450 V1220683 L transposase COG0675 Cluster_360426 V1220685 MODB map02010 P molybdate abc transporter COG4149 Cluster_166145 V1220686 map02010 V ABC-2 type transporter COG0842 Cluster_150451 V1220687 S conjugation system ATPase, TraG family 0XSHU Cluster_385874 V1220688 MAF D MAF-like protein COG0424 Cluster_695905 V1220689 YBBK J Purine nucleoside phosphorylase COG1683 Cluster_475736 V1220690 CAS4 L crispr-associated protein Cas4 COG1468 Cluster_215000 V1220691 AROF map00400,map01100,map01110,map01230 E phospho-2-dehydro-3-deoxyheptonate aldolase COG2876 Cluster_419722 V1220693 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_389417 V1220694 SUN J Fmu (Sun) domain-containing protein COG0144 Cluster_371959 V1220696 S Domain of unknown function (DUF1837) 100DA Cluster_436949 V1220697 L helicase COG1204 Cluster_322962 V1220700 K Helix-turn-helix domain, rpiR family COG1737 Cluster_152885 V1220701 M Inherit from COG: YD repeat protein COG3209 Cluster_153656 V1220704 U, W Pfam:YadA COG5295 Cluster_162048 V1220706 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_444948 V1220707 RAIA J ribosomal subunit Interface protein COG1544 Cluster_540125 V1220711 KDPB map02020 P One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) COG2216 Cluster_421518 V1220712 L Transposase 11X46 Cluster_153657 V1220713 ADDB L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination COG3857 Cluster_255211 V1220714 ARGD map00300,map00330,map01100,map01110,map01120,map01210,map01230 E acetylornithine aminotransferase COG4992 Cluster_412494 V1220715 K transcriptional regulator COG1309 Cluster_384109 V1220716 S NA 11VAR Cluster_428994 V1220718 MSRA S methionine sulfoxide reductase A 0YJ5R Cluster_687565 V1220719 L UvrD REP helicase COG0210 Cluster_174521 V1220720 YBDL map00300,map01100,map01120,map01230 E Aminotransferase COG0436 Cluster_182989 V1220722 RECQ2 map03018 L ATP-dependent DNA helicase COG0514 Cluster_360427 V1220724 FTSK D cell division protein FtsK COG1674 Cluster_871828 V1220725 TRAI S Conjugative transposon protein TraI 0ZVHG Cluster_198892 V1220726 TRAJ S conjugative transposon 0XP5P Cluster_273715 V1220727 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_184681 V1220729 YPJC S YitT family COG1284 Cluster_545942 V1220730 PTRB map05142,map05143 E Oligopeptidase b COG1770 Cluster_365302 V1220731 MT0808 S Inherit from COG: deacetylase COG3233 Cluster_307871 V1220734 TRAA L TrwC relaxase COG0507 Cluster_276399 V1220736 ISPA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_171151 V1220738 M Cell wall binding repeat 2-containing protein COG2247 Cluster_421519 V1220739 YEBR T gaf domain protein COG1956 Cluster_294029 V1220741 S NA 11FM9 Cluster_157820 V1220742 TRAA map03440 L mobA MobL family protein COG0507 Cluster_268396 V1220744 METN map02010 P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COG1135 Cluster_321390 V1220746 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_157821 V1220747 U, W Pfam:YadA COG5295 Cluster_306560 V1220749 S alpha beta COG0596 Cluster_234894 V1220750 INSI L transposase COG2826 Cluster_158692 V1220751 MOD map00340,map00350,map00624,map01120 L DNA methylase COG2189 Cluster_582756 V1220752 S Prophage pi2 protein 37 11UE0 Cluster_276400 V1220754 S NA 0YWA6 Cluster_824688 V1220755 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_309284 V1220756 RPSB map03010 J 30S ribosomal protein S2 COG0052 Cluster_844072 V1220757 S NA 128M4 Cluster_348943 V1220762 S NA 0YM1X Cluster_161211 V1220766 AROP E amino acid COG1113 Cluster_160381 V1220767 TRSE U traE protein COG3451 Cluster_161212 V1220768 MMPL3 H MMPL domain protein COG2409 Cluster_161213 V1220769 FTSI map00550,map01100 M Stage V sporulation protein D COG0768 Cluster_163686 V1220770 S Filamentation induced by cAMP protein fic COG3177 Cluster_344120 V1220771 ARGB map00330,map01100,map01110,map01210,map01230 E nag kinase COG0548 Cluster_517829 V1220772 ARGJ map00330,map01100,map01110,map01210,map01230 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) COG1364 Cluster_847970 V1220773 MT1132 S NA 12B5W Cluster_407064 V1220774 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_162049 V1220779 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_224334 V1220782 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_585942 V1220787 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_321391 V1220788 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_408825 V1220789 S Membrane COG4330 Cluster_163687 V1220790 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_504707 V1220791 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_517830 V1220793 YXIE T Universal stress protein COG0589 Cluster_197896 V1220794 S Pfam:DUF2081 COG3472 Cluster_367017 V1220795 S Domain of unknown function (DUF1803) 0ZGP5 Cluster_163688 V1220796 GLSA map00250,map00330,map00471,map00910,map01100,map01120,map04724,map04727,map04964 E Glutaminase COG2066 Cluster_606791 V1220798 CLGR K Transcriptional regulator 122H2 Cluster_427095 V1220799 K, T Phage shock protein A COG1842 Cluster_407065 V1220800 S NA 11SFQ Cluster_526075 V1220801 SP_2122 S Major Facilitator 121QJ Cluster_242533 V1220802 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_504708 V1220803 DPNII V Type II restriction 0YTH4 Cluster_358763 V1220804 map04112 L DNA methylase n-4 n-6 domain protein COG0863 Cluster_589255 V1220805 MANO S Domain of unknown function (DUF956) COG4687 Cluster_205050 V1220806 S Membrane COG1434 Cluster_336574 V1220807 MT1025 S conserved transmembrane protein 12614 Cluster_781095 V1220808 XDHB map00230,map00633,map00680,map00720,map01100,map01120 C Dehydrogenase COG1319 Cluster_450982 V1220811 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_421520 V1220812 V abc transporter permease protein 0XQE2 Cluster_551902 V1220813 HIT F, G histidine triad (HIT) protein COG0537 Cluster_482667 V1220814 SCLAV_0395 V ABC transporter COG1132 Cluster_191667 V1220815 ZWF map00030,map00480,map01100,map01110,map01120 G glucose-6-phosphate 1-dehydrogenase COG0364 Cluster_599617 V1220816 PDXP G hydrolase COG0647 Cluster_363561 V1220817 SCLAV_1000 S TPR-repeat-containing protein 10GX4 Cluster_363562 V1220818 O sucraseferredoxin family COG4759 Cluster_629045 V1220819 S Secreted protein 11Z2N Cluster_523156 V1220821 S NA 0ZEDM Cluster_296780 V1220824 TELA P Resistance protein COG3853 Cluster_484993 V1220825 S Peptidase family M50 0Z3K7 Cluster_166146 V1220826 TERY_3118 L Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) COG0553 Cluster_482668 V1220827 LKTB3 V ABC transporter, ATP-binding protein COG2274 Cluster_531634 V1220828 CYCMA_0607 S transposase 11H93 Cluster_167683 V1220835 NDVA2 V ABC transporter, ATP-binding protein COG1132 Cluster_824691 V1220836 S inner membrane protein YbaN COG2832 Cluster_168532 V1220839 L type iii restriction protein res subunit COG3886 Cluster_728150 V1220840 PEPF E Oligoendopeptidase f COG1164 Cluster_333546 V1220841 Q Methyltransferase Type COG0500 Cluster_236095 V1220842 G Major Facilitator superfamily 0XP3M Cluster_242534 V1220843 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (alpha subunit) COG0587 Cluster_206128 V1220844 TAL map00010,map00030,map00500,map00520,map00710,map01051,map01100,map01110,map01120,map01230 G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) COG0176 Cluster_169461 V1220845 DPNA L helicase COG4646 Cluster_336575 V1220846 S NA 0YHMP Cluster_416144 V1220850 AHPC O alkyl hydroperoxide reductase COG0450 Cluster_456895 V1220851 AHPD S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) COG2128 Cluster_170328 V1220852 FADD map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG0318 Cluster_762257 V1220854 OORD map00020,map00720,map01100,map01120 C 4Fe-4S Ferredoxin, iron-sulfur binding domain protein COG1146 Cluster_170329 V1220855 ACEE map00010,map00020,map00620,map00650,map01100,map01110,map01120 C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) COG2609 Cluster_549001 V1220856 CLOLE_0796 L recT protein COG3723 Cluster_333547 V1220857 CLOLE_0797 S NA 11N1T Cluster_269743 V1220858 MT3308 S secreted protein 0XRRW Cluster_721537 V1220859 RHLE map03018 L Helicase COG0513 Cluster_170330 V1220860 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_515159 V1220862 map00010 G Cellulase (glycosyl hydrolase family 5) COG2723 Cluster_324533 V1220866 P cation diffusion facilitator family transporter COG0053 Cluster_171972 V1220868 FAS map00061,map01100 I fatty acid synthase COG4982 Cluster_517831 V1220869 OGT L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) COG0350 Cluster_427096 V1220870 YNIA map00564,map01100 G Fructosamine kinase COG3001 Cluster_350560 V1220871 S NA 0YBRU Cluster_824692 V1220873 CINA H competence damage-inducible protein COG1546 Cluster_172880 V1220874 TNPA L transposase COG4644 Cluster_636898 V1220875 MIHF S integration host factor 11UU9 Cluster_416145 V1220876 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG0194 Cluster_260351 V1220878 FBPC map02010 E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COG3842 Cluster_285928 V1220880 ENTE map01053 Q 2,3-dihydroxybenzoate-AMP ligase COG1021 Cluster_545943 V1220882 L ATP-dependent endonuclease of the OLD COG3593 Cluster_339554 V1220883 L Superfamily I DNA and RNA helicases-like COG0210 Cluster_502307 V1220887 RPLY map03010 J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) COG1825 Cluster_632866 V1220888 S alkaline shock protein COG1302 Cluster_718205 V1220890 map00350,map00362,map00627,map00642,map00903,map01120 S acetyltransferase, (GNAT) family COG0456 Cluster_805097 V1220891 S Nucleotidyltransferase domain 0ZNBK Cluster_174522 V1220892 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_517832 V1220893 S Inherit from NOG: LPXTG-motif cell wall anchor domain protein 0YEBJ Cluster_537314 V1220894 S ATP cone domain 0Y76S Cluster_674157 V1220895 XTH map03410 L Exodeoxyribonuclease III COG0708 Cluster_195303 V1220896 HEMH map00860,map01100,map01110 H Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) COG0276 Cluster_652933 V1220897 S Protein of unknown function (DUF2029) 0Y6D7 Cluster_563705 V1220902 TNPR L Resolvase COG1961 Cluster_407066 V1220903 L transposase COG4644 Cluster_276401 V1220904 BETA map00260,map01100 E Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) COG2303 Cluster_175339 V1220905 CAPA M Capsule synthesis protein COG2843 Cluster_816909 V1220907 RPSU map03010 J 30S ribosomal protein S21 122SW Cluster_875915 V1220908 MT2226 map00350,map00362,map00627,map00642,map00903,map01120 S Gcn5-related n-acetyltransferase COG0456 Cluster_285929 V1220909 S NA 11GVV Cluster_175340 V1220911 M domain protein COG4932 Cluster_176133 V1220914 DPNA L helicase COG4646 Cluster_176134 V1220918 S NA 12D1P Cluster_454962 V1220919 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0847 Cluster_419723 V1220922 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_446992 V1220923 S Terminase COG4626 Cluster_699184 V1220924 S NA 0YRYB Cluster_875916 V1220925 S NA 0XVZI Cluster_176955 V1220926 CYSN map00230,map00450,map00920,map01100,map01120 P may be the GTPase, regulating ATP sulfurylase activity (By similarity) COG2895 Cluster_262972 V1220927 CYDC map02010 V (ABC) transporter COG4987 Cluster_596100 V1220929 G Major Facilitator COG2807 Cluster_181155 V1220931 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_432974 V1220932 MT0057 S integral membrane protein COG5650 Cluster_199891 V1220936 ARGK E lAO AO transport system ATPase COG1703 Cluster_336576 V1220937 YBIW map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_276402 V1220938 S NA 0XQDK Cluster_540126 V1220939 NMB0459 S Filamentation induced by cAMP protein fic COG3177 Cluster_423379 V1220940 YCFI map02010 V abc transporter COG1132 Cluster_436950 V1220942 U relaxase mobilization nuclease domain protein COG3843 Cluster_836129 V1220943 TCSR3 T regulatoR COG2197 Cluster_238611 V1220944 T Histidine kinase COG4585 Cluster_183805 V1220945 AARI_34870 L transposase of ISAar22, IS481 family COG2801 Cluster_401791 V1220947 V restriction endonuclease 11GCV Cluster_512456 V1220948 DCM map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_621538 V1220949 RNY S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 Cluster_557683 V1220951 ACPS map00770 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) COG0736 Cluster_410682 V1220952 FAS map00061,map01100 I fatty acid synthase COG4982 Cluster_182087 V1220953 RUMAL_0348 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_427097 V1220954 PTH J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) COG0193 Cluster_449012 V1220957 YGAC J UPF0374 protein COG3557 Cluster_400002 V1220959 YLBB V abc transporter permease protein COG0577 Cluster_614102 V1220960 DNAQ map03420,map03430 L Uvrd rep helicase COG2176 Cluster_316857 V1220961 RC1_2786 L transposase COG5433 Cluster_781097 V1220963 YYAH map00620,map04011 E Glyoxalase Bleomycin resistance protein (Dioxygenase COG0346 Cluster_181156 V1220964 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_257728 V1220966 L Integrase COG0582 Cluster_543003 V1220967 S NA 0YIA5 Cluster_489624 V1220968 L helicase COG1204 Cluster_517833 V1220969 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_440955 V1220970 AATB map02010 E ABC transporter substrate-binding protein COG0834 Cluster_387719 V1220974 THYX map00240,map00670 F Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) COG1351 Cluster_599618 V1220975 DAPA map00300,map01100,map01110,map01120,map01230 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) COG0329 Cluster_329091 V1220976 XERD L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_603182 V1220977 NUDF map00230 F nudix hydrolase COG0494 Cluster_401792 V1220979 S O-methyltransferase-like protein 106VG Cluster_275066 V1220980 MSCS M mechanosensitive ion channel COG0668 Cluster_579518 V1220982 S NA 0XY0U Cluster_847972 V1220985 S NA 0XNWW Cluster_648843 V1220986 S Gcn5-related n-acetyltransferase 1221G Cluster_257729 V1220988 ACCBC map00061,map01100 I carboxylase COG4770 Cluster_184682 V1220990 S Relaxase mobilization nuclease 0Y9PG Cluster_321392 V1220991 DCP E oligopeptidase A COG0339 Cluster_477943 V1220993 ATPF map00190,map00195,map01100 C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) COG0711 Cluster_442971 V1220994 map00350,map00362,map00627,map00642,map00903,map01120 J -acetyltransferase COG1670 Cluster_184683 V1220995 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_184684 V1220996 FAS map00061,map00350,map00362,map00627,map00642,map00903,map01100,map01120 I synthase COG4982 Cluster_184685 V1220997 TRAA L TrwC relaxase COG0507 Cluster_492121 V1220999 LPD map00010,map00020,map00260,map00280,map00620,map01100,map01110,map01120 C dihydrolipoyl dehydrogenase COG1249 Cluster_766223 V1221002 S NA 0YIA5 Cluster_185562 V1221003 NDVA2 V ABC transporter, ATP-binding protein COG1132 Cluster_361993 V1221004 map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_820708 V1221005 S NA 11V4N Cluster_724886 V1221008 RPSO map03010 J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) COG0184 Cluster_692094 V1221009 ARSA map00600,map04142 P Arylsulfatase COG3119 Cluster_294030 V1221013 PSTA map02010 P phosphate abc transporter COG0581 Cluster_777355 V1221014 TRPG map00230,map00400,map00790,map00983,map01100,map01110,map01230 E anthranilate synthase COG0512 Cluster_449014 V1221015 HSDM V HsdM N-terminal domain COG0286 Cluster_678604 V1221016 S NA 0Y86B Cluster_264350 V1221018 RLUD J Pseudouridine synthase COG0564 Cluster_800894 V1221019 LSPA map03060 M, U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) COG0597 Cluster_621539 V1221020 MOAA map00790,map01100,map04122 H Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) COG2896 Cluster_370339 V1221021 FADD4 map00071,map01100,map03320,map04146,map04920 Q Amp-dependent synthetase and ligase COG0318 Cluster_377057 V1221023 S gCN5-related N-acetyltransferase 11U5D Cluster_189025 V1221024 PEPP E peptidase, M24 COG0006 Cluster_342533 V1221026 S NA 0XWFB Cluster_377058 V1221028 ELI_1297 O phage portal protein HK97 family COG4695 Cluster_189026 V1221029 S degv family COG1307 Cluster_492122 V1221030 FEOA P Ferrous iron transport protein A COG1918 Cluster_339555 V1221031 S NA 11NX4 Cluster_702264 V1221032 TRA L transposase COG2826 Cluster_189885 V1221034 TOCE_0081 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_412495 V1221036 FTSW D cell cycle protein COG0772 Cluster_573189 V1221043 TATD L Hydrolase, tatD family COG0084 Cluster_606792 V1221045 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_625321 V1221046 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_338124 V1221047 S PspC domain-containing protein 0Y3A6 Cluster_401793 V1221050 L phage plasmid primase, p4 family COG3378 Cluster_674158 V1221051 S NA 11QFB Cluster_432975 V1221052 TNPB L transposase COG0675 Cluster_410683 V1221054 S NA 0Y84K Cluster_669760 V1221057 YRDD L Dna topoisomerase COG0551 Cluster_434892 V1221060 S Inherit from COG: Pfam:DUF567 COG4894 Cluster_272380 V1221063 YFMR S Abc transporter COG0488 Cluster_327595 V1221064 SUCA map00020,map00310,map00380,map01100,map01110,map01120 C 2-oxoglutarate dehydrogenase, E1 COG0567 Cluster_423380 V1221065 FATD map02010 P permease protein COG4606 Cluster_573190 V1221067 MT2231 K transcriptional regulatory protein 11UQP Cluster_465122 V1221068 PKNL T Serine Threonine protein kinase COG2815 Cluster_194421 V1221069 PFLB map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_194422 V1221070 S NA 11NI8 Cluster_194423 V1221071 SURB S G5 domain protein 0ZVV3 Cluster_754966 V1221073 YSDC map00500,map01100 E Peptidase m42 family protein COG1363 Cluster_194424 V1221074 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_400003 V1221075 TMK map00240,map01100 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) COG0125 Cluster_592622 V1221078 RPSL map03010 J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) COG0048 Cluster_195304 V1221080 V Type I restriction-modification system R subunit COG4096 Cluster_398278 V1221081 S Methyltransferase 11PHP Cluster_363563 V1221082 SPD S Prophage Lp1 protein 65 0XSDQ Cluster_629046 V1221085 BL01323 M Cell wall binding repeat 2-containing protein 0ZKZU Cluster_292655 V1221086 M polysaccharide biosynthesis protein COG2244 Cluster_382336 V1221088 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_195305 V1221089 TRAA L TrwC relaxase COG0507 Cluster_492123 V1221090 LACD map00052,map01100 G Aldolase COG3684 Cluster_385875 V1221091 HRRA T regulatoR COG2197 Cluster_632867 V1221092 HRRS T Histidine kinase 0XNMH Cluster_268397 V1221094 DAPF map00300,map01100,map01110,map01120,map01230 E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) COG0253 Cluster_394771 V1221095 RPSE map03010 J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) COG0098 Cluster_824697 V1221096 RPMD map03010 J 50S ribosomal protein L30 COG1841 Cluster_836131 V1221097 RPLO map03010 J Binds to the 23S rRNA (By similarity) COG0200 Cluster_711589 V1221100 SCLAV_1045 S Membrane COG3346 Cluster_196156 V1221101 S domain protein 0YF83 Cluster_275067 V1221102 S NA 11MTE Cluster_467199 V1221103 DPS P ferritin dps family protein COG0783 Cluster_262973 V1221105 MODA map02010 P ABC transporter, periplasmic molybdate-binding protein COG0725 Cluster_276403 V1221108 S Cutinase 0YHDW Cluster_196967 V1221119 UUP S Abc transporter COG0488 Cluster_444949 V1221120 V Restriction modification system DNA specificity COG0732 Cluster_446993 V1221122 ELI_3039 K RNA Polymerase 1261F Cluster_339556 V1221123 map00230 Q RelA SpoT domain protein COG2357 Cluster_389418 V1221124 K NA 0Z0MV Cluster_200890 V1221126 L Integrase COG0582 Cluster_648845 V1221130 PPA map00190 C Inorganic pyrophosphatase COG0221 Cluster_563706 V1221133 MT3543 S NA 11ISP Cluster_502308 V1221134 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_410684 V1221135 SRTA M (sortase) family COG3764 Cluster_520382 V1221136 MCBR K Transcriptional regulator 11WG2 Cluster_198893 V1221137 SBCC3 S Cytosolic protein COG4913 Cluster_198894 V1221139 TRBE map03070 U conjugal transfer ATPase COG3451 Cluster_421521 V1221141 RNMV L Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) COG1658 Cluster_360428 V1221142 SGLY_1036 V (ABC) transporter COG1136 Cluster_199892 V1221143 MUTY map03410 L a g-specific adenine glycosylase COG1194 Cluster_257730 V1221144 BCGIA V Type II restriction modification enzyme methyltransferase COG0286 Cluster_820709 V1221146 S NA 0YVZD Cluster_456896 V1221149 ANSA map00250,map00460,map00910,map01100,map01110 E L-asparaginase COG0252 Cluster_458862 V1221150 S secreted protein 0Y4BT Cluster_789218 V1221151 WANG_1499 S Transposase 11N3I Cluster_444950 V1221155 BMUL_5568 S nerd domain protein 0XSNF Cluster_785222 V1221156 PUCB map00230,map01100,map01120 O 4-diphosphocytidyl-2c-methyl-d-erythritol synthase COG2068 Cluster_458863 V1221159 S NA 0ZHU9 Cluster_220814 V1221162 PCKA map00010,map00020,map00620,map00710,map01100,map01110,map01120 C Phosphoenolpyruvate Carboxylase COG1866 Cluster_201883 V1221163 CAP5F map00051,map00363,map00521,map00523,map00591,map00625,map00650,map01100,map01110,map01120 G, M epimerase dehydratase COG1898 Cluster_201884 V1221164 S Cutinase 0YUSA Cluster_377059 V1221165 G Major Facilitator superfamily 0XQFH Cluster_751514 V1221166 S ABC transporter, ATPase COG3044 Cluster_669761 V1221167 S Protein of unknown function (DUF2580) COG4842 Cluster_705355 V1221168 BCAV_3206 map05152 S Proteins of 100 residues with WXG COG4842 Cluster_652934 V1221170 S rRNA biogenesis protein Rrp5 0XUK3 Cluster_702265 V1221172 CLCAR_2470 G aldose 1-epimerase COG2017 Cluster_355400 V1221173 YWQD M Capsular exopolysaccharide family COG0489 Cluster_734686 V1221174 G, M Capsular polysaccharide biosynthesis protein COG4464 Cluster_606794 V1221175 RBPA S NA 11U3N Cluster_348944 V1221176 SUFC O feS assembly ATPase SufC COG0396 Cluster_579519 V1221178 S Toxic component of a toxin-antitoxin (TA) module. A 1274P Cluster_576413 V1221179 MT0235 map00051 M glycosyl transferase group 1 COG0438 Cluster_259047 V1221181 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_398279 V1221182 LIVK map02010 E Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein COG0683 Cluster_617875 V1221183 MUTT1 L NUDIX hydrolase COG0494 Cluster_250312 V1221186 RRGB M Lpxtg-motif cell wall anchor domain protein 0XSEP Cluster_238612 V1221188 S NA 11NGH Cluster_330490 V1221190 S NA 0ZMX8 Cluster_800895 V1221192 S NA 17D58@proNOG Cluster_339557 V1221196 S Cell surface protein 0ZXQA Cluster_477945 V1221197 QUEF map00790,map01100 S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) COG0780 Cluster_206129 V1221198 V Type III COG3587 Cluster_206130 V1221199 LHR L helicase COG1201 Cluster_309285 V1221201 L site-specific recombinase, phage integrase family 0ZQ44 Cluster_695908 V1221203 YJGR S ATP-binding protein COG0433 Cluster_549002 V1221205 S NA 0YWKD Cluster_206131 V1221206 YBBC V conserved protein UCP016719 COG3876 Cluster_206132 V1221207 ACTP P p-type atpase COG2217 Cluster_440956 V1221208 YUTD S transcriptional regulator COG4470 Cluster_412496 V1221209 map00230 Q RelA SpoT domain protein COG2357 Cluster_579520 V1221210 HSLR J Heat shock protein COG1188 Cluster_442972 V1221211 BL01877 K Transcriptional regulator COG1309 Cluster_458864 V1221212 GLFT M Transferase COG1216 Cluster_632868 V1221213 SULP P sulfate transporter COG0659 Cluster_385876 V1221214 THIE map00730,map01100 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) COG0352 Cluster_657049 V1221217 FTSL D Essential cell division protein (By similarity) COG4839 Cluster_669762 V1221218 BL02952 S Membrane COG1434 Cluster_683133 V1221219 LMRA V ABC transporter COG1132 Cluster_299464 V1221220 DAPB map00300,map01100,map01110,map01120,map01230 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) COG0289 Cluster_427098 V1221222 PSTS map02010,map02020,map05152 P phosphate COG0226 Cluster_582758 V1221224 S NA 183FK@proNOG Cluster_762260 V1221226 YYZM S protein, conserved in bacteria COG4481 Cluster_480356 V1221229 V HNH endonuclease COG1403 Cluster_543004 V1221230 SERB1 E HAD-superfamily subfamily IB hydrolase COG0560 Cluster_469340 V1221231 S -acetyltransferase 122ZA Cluster_718208 V1221232 YEIH S Membrane COG2855 Cluster_257731 V1221233 PCCB I carboxylase, beta COG4799 Cluster_606795 V1221239 DIVIC D Septum formation initiator COG2919 Cluster_307872 V1221241 E Sodium:solute symporter family COG0591 Cluster_339558 V1221242 S NA 0YYC5 Cluster_210472 V1221243 S (LipO)protein 0XSYT Cluster_579521 V1221244 TMK map00240,map01100 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) COG0125 Cluster_264351 V1221246 BMUL_3652 V Abortive infection bacteriophage resistance protein COG4823 Cluster_210473 V1221247 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_661280 V1221250 TRXA2 O Thioredoxin COG0526 Cluster_871829 V1221251 COAD map00770,map01100 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) COG0669 Cluster_416146 V1221252 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_728151 V1221253 RECG map03440 L ATP-dependent DNA helicase RecG COG1200 Cluster_336577 V1221254 KDPE map02020 T Response regulator receiver domain protein COG0745 Cluster_321393 V1221256 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_796959 V1221257 NUDF map00230 F nudix hydrolase COG0494 Cluster_210474 V1221259 PGN_0946 S Membrane COG1033 Cluster_449015 V1221261 T HPP family COG3448 Cluster_610454 V1221262 S NA 0YX7F Cluster_211615 V1221263 CAT1 map00281,map00620,map00626,map01110,map01120 C Transferase COG0427 Cluster_211616 V1221264 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_589257 V1221265 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_449016 V1221266 NRDI F Probably involved in ribonucleotide reductase function (By similarity) COG1780 Cluster_365303 V1221267 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_212698 V1221269 S fad dependent oxidoreductase COG2509 Cluster_469341 V1221271 YBBK J Purine nucleoside phosphorylase COG1683 Cluster_213818 V1221276 S NA 0YH2T Cluster_215001 V1221279 S NA 11FSG Cluster_315329 V1221281 TRMB C Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_489626 V1221285 P phosphonate ABC transporter substrate-binding protein COG3221 Cluster_254003 V1221286 B565_1256 S NA 11JBM Cluster_298183 V1221287 E Extracellular solute-binding protein, family 5 COG0747 Cluster_904895 V1221289 MSRB O reductase COG0229 Cluster_789219 V1221290 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_450983 V1221291 RV2876 S Protein of unknown function (DUF2631) 0Y36A Cluster_324535 V1221293 TELA P Resistance protein COG3853 Cluster_661281 V1221294 E amidohydrolase COG1473 Cluster_705356 V1221295 E amidohydrolase COG1473 Cluster_523158 V1221296 YJEE S protein family UPF0079, ATPase COG0802 Cluster_215002 V1221299 map00500,map01100 N Alpha-L-fucosidase 0XPGV Cluster_603183 V1221300 RPLL map03010 J Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) COG0222 Cluster_809140 V1221302 K Transcriptional regulator COG1476 Cluster_517834 V1221303 S NA 12D5B Cluster_216134 V1221304 U, W Pfam:YadA COG5295 Cluster_216135 V1221305 CSP1 M LGFP repeat COG5479 Cluster_566901 V1221307 map02010 V (ABC) transporter COG1131 Cluster_216136 V1221309 S NA 0Y940 Cluster_728152 V1221312 S YGGT family COG0762 Cluster_793016 V1221317 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_353725 V1221318 RSME S Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) COG1385 Cluster_494606 V1221319 S NA 11QS8 Cluster_509875 V1221320 S NA 100BM Cluster_218467 V1221321 SALY V ABC transporter COG0577 Cluster_800898 V1221322 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins COG0706 Cluster_436951 V1221323 RSMG M Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) COG0357 Cluster_781100 V1221324 REPA S Phage replisome organizer 0YDCP Cluster_741436 V1221325 S Transglycosylase-associated protein 125P9 Cluster_219624 V1221327 S YbbR-like protein 11RE7 Cluster_219625 V1221329 M Inherit from NOG: Polymorphic outer membrane protein 11KKP Cluster_754967 V1221331 S Plasmid pRiA4b ORF-3 family protein 1026Y Cluster_255212 V1221332 ATP2C1 P p-type ATPase COG0474 Cluster_800899 V1221336 GUFA P Mediates zinc uptake. May also transport other divalent cations (By similarity) COG0428 Cluster_219626 V1221337 KDPD map02020 T Osmosensitive K channel His kinase sensor COG2205 Cluster_507287 V1221338 S septicolysin 11TVT Cluster_509876 V1221339 MT0235 map00051 M glycosyl transferase group 1 COG0438 Cluster_339559 V1221340 YFIH S Multi-copper polyphenol oxidoreductase laccase COG1496 Cluster_326032 V1221342 PHOA map00521,map00627,map00790,map01100,map01110,map01120,map02020 P alkaline phosphatase COG1785 Cluster_226631 V1221343 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase ii COG0046 Cluster_292657 V1221344 ISPE map00900,map01100,map01110 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COG1947 Cluster_305174 V1221345 CDR P pyridine nucleotide-disulfide oxidoreductase COG0607 Cluster_614103 V1221346 S NA 0ZHU9 Cluster_465123 V1221347 DINF V Mate efflux family protein COG0534 Cluster_517835 V1221348 NRNA J phosphoesterase RecJ domain protein COG0618 Cluster_220815 V1221349 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_537316 V1221350 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_473599 V1221351 PPNK map00760,map01100 G Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) COG0061 Cluster_766227 V1221354 BDP_1102 V ABC transporter COG1136 Cluster_324536 V1221355 YLBB V abc transporter permease protein COG0577 Cluster_310728 V1221356 FABG3 map00140,map01100 S Short-chain dehydrogenase reductase Sdr COG1028 Cluster_625322 V1221358 ISCA O iron--sulfur cluster insertion protein erpA COG0316 Cluster_492124 V1221359 S Peptidase, S41 11XDZ Cluster_520383 V1221360 L transposase, IS605 OrfB COG0675 Cluster_243884 V1221364 P peroxidase COG2837 Cluster_223159 V1221366 PHTE S Pneumococcal histidine triad protein E 0Y9TQ Cluster_403570 V1221368 Y3395 S exported protein 11NNA Cluster_473600 V1221369 M Glycosyl transferase (Group 1 11H1P Cluster_489627 V1221370 S NA 0ZWIA Cluster_279067 V1221371 OXLT G Major Facilitator 0XQUK Cluster_288694 V1221372 map02010 P Transporter Permease Protein COG1178 Cluster_751515 V1221373 ERUM3880 S phage protein COG5410 Cluster_471489 V1221374 S NA 0Y208 Cluster_554766 V1221375 S helix-turn-helix domain protein 122WR Cluster_469342 V1221376 S NA 0ZA8M Cluster_644791 V1221382 S NA 123I8 Cluster_721539 V1221384 MPTA S Membrane 0XT70 Cluster_385877 V1221385 L Pfam:Transposase_11 0ZVJY Cluster_585943 V1221388 FAS map00061,map01100 I fatty acid synthase COG4982 Cluster_294031 V1221389 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_560750 V1221390 SSDA map00250,map00350,map00650,map01100,map01120 C Dehydrogenase COG1012 Cluster_432976 V1221391 NAGD map00627,map01120 G had-superfamily hydrolase, subfamily iia COG0647 Cluster_268398 V1221395 DPRE1 C FAD linked oxidase domain protein COG0277 Cluster_777356 V1221397 TRA L transposase COG2826 Cluster_350561 V1221398 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_227767 V1221401 ARGG map00250,map00330,map01100,map01110,map01230 E Citrulline--aspartate ligase COG0137 Cluster_824700 V1221406 S Protein of unknown function (DUF3042) 0Y0YB Cluster_347328 V1221407 HUNADC P transporter COG0471 Cluster_227768 V1221409 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_724887 V1221414 D, J addiction module toxin, RelE StbE family COG2026 Cluster_741438 V1221415 S toxin-antitoxin system, antitoxin component, ribbon-helix-helix 121PE Cluster_557684 V1221420 DCD map00240,map01100 F deoxycytidine triphosphate deaminase COG0717 Cluster_526076 V1221422 S NA 0ZEZ0 Cluster_360429 V1221424 EMBC M Arabinosyltransferase 0XSQE Cluster_789221 V1221425 AFTA M Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases 0Z57H Cluster_230094 V1221427 TRAG S conjugation system ATPase, TraG family 0XSHU Cluster_230095 V1221428 map01053 Q non-ribosomal peptide synthetase COG1020 Cluster_266991 V1221429 PARE L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_363565 V1221430 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_231271 V1221431 S Tape measure protein COG5281 Cluster_276404 V1221432 YITL S S1 RNA binding domain protein COG2996 Cluster_809142 V1221433 S NA 0Z6X2 Cluster_573191 V1221434 MT3438 K Transcriptional regulator COG0789 Cluster_289982 V1221436 MMPL3 H MMPL domain protein COG2409 Cluster_497113 V1221438 SP_1785 S Protein of unknown function (DUF3013) 1289G Cluster_345745 V1221439 TNP L transposase COG3316 Cluster_504710 V1221441 AFTD S coagulation factor 5 8 type domain-containing protein 0YR9E Cluster_566902 V1221442 LPPL S prolipoprotein LppL 0Z2Q4 Cluster_438980 V1221443 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) COG0167 Cluster_391147 V1221445 SCLAV_3539 G phosphoglycerate mutase COG0406 Cluster_840007 V1221446 HEML map00860,map01100,map01110 H Glutamate-1-semialdehyde aminotransferase COG0001 Cluster_232432 V1221447 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_232433 V1221448 S NA 101UU Cluster_754969 V1221449 S Nucleotidyl transferase of unknown function (DUF1814) 0XP6B Cluster_504711 V1221453 SCLAV_0509 S Cytochrome c oxidase caa3-type, assembly factor ctag-related protein COG3336 Cluster_632869 V1221454 map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_318433 V1221455 AFER_0154 L transposase IS3 IS911 family protein COG2801 Cluster_232435 V1221457 L Integrase 0YTFQ Cluster_260352 V1221458 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_440958 V1221459 ELI_3039 K RNA Polymerase 1261F Cluster_430969 V1221461 S Frg domain protein 0ZXCB Cluster_233701 V1221462 PPC map00620,map00680,map00710,map00720,map01100,map01120 C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) COG2352 Cluster_758496 V1221463 C, O Glutaredoxin-like domain (DUF836) COG0526 Cluster_450984 V1221464 SERB1 E HAD-superfamily subfamily IB hydrolase COG0560 Cluster_307873 V1221465 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_847975 V1221466 LEPB map03060 U Signal peptidase i COG0681 Cluster_234895 V1221468 M cell wall-binding protein COG2247 Cluster_234896 V1221469 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_728153 V1221470 YYAT map00350,map00362,map00627,map00642,map00903,map01120 Q acetyltransferase 121PI Cluster_625324 V1221472 SCLAV_0069 S Membrane COG2311 Cluster_758497 V1221473 RPMB map03010 J 50s ribosomal protein l28 COG0227 Cluster_851758 V1221474 RPMG map03010 J 50S ribosomal protein L33 COG0267 Cluster_405380 V1221475 COMF map00230,map00250,map01100,map01110 S Competence protein COG1040 Cluster_423381 V1221479 GPSA map00564 C NADPH-dependent glycerol-3-phosphate dehydrogenase COG0240 Cluster_711591 V1221480 MUTT1 L NUDIX hydrolase COG0494 Cluster_291297 V1221482 MURE map00300,map00550 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_339560 V1221485 S Abi-like protein 11WV5 Cluster_329092 V1221486 NMB0459 S Filamentation induced by cAMP protein fic COG3177 Cluster_820711 V1221487 MAA map00350,map00362,map00627,map00642,map00903,map01120 S O-acetyltransferase COG0110 Cluster_480357 V1221488 L Transposase, IS605 OrfB family 0XT7Q Cluster_610456 V1221490 S NA 0XXFR Cluster_296781 V1221491 SCLAV_2565 map00620 L Beta-lactamase domain protein COG0491 Cluster_467200 V1221493 ASP23 S alkaline shock protein COG1302 Cluster_614104 V1221494 ARSC P Transcriptional regulator, Spx MgsR family COG1393 Cluster_705357 V1221496 RPSQ map03010 J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal COG0186 Cluster_394772 V1221497 FEPD map02010 P transport system permease protein COG0609 Cluster_714963 V1221498 SIDE P Siderophore-interacting protein COG2375 Cluster_238613 V1221500 M domain protein COG4932 Cluster_543006 V1221501 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_281713 V1221502 DPRA L DNA protecting protein DprA COG0758 Cluster_554767 V1221503 MODC map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_238614 V1221505 M Inherit from COG: YD repeat protein COG3209 Cluster_238615 V1221506 VIRD4 map03070,map05120 U TraG TraD family protein COG3505 Cluster_789222 V1221507 K Transcriptional regulator COG1309 Cluster_669764 V1221508 BL01877 K Transcriptional regulator COG1309 Cluster_279068 V1221509 map00071,map00310,map00380,map01100 I acyl-CoA dehydrogenase domain-containing protein COG1960 Cluster_440959 V1221510 map00480,map00590 O Glutathione peroxidase COG0386 Cluster_321394 V1221512 V restriction enzyme 17CDW@proNOG Cluster_484995 V1221513 map03440 K Transcriptional regulator COG2865 Cluster_751516 V1221514 DCTP C symporter COG1301 Cluster_748094 V1221515 HEMB map00860,map01100,map01110 H delta-aminolevulinic acid dehydratase COG0113 Cluster_355401 V1221516 HEML map00860,map01100,map01110 H Glutamate-1-semialdehyde aminotransferase COG0001 Cluster_892140 V1221517 L NA 0Z8MW Cluster_239887 V1221518 HSDS V Restriction modification system DNA specificity COG0732 Cluster_296782 V1221520 YDIA S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) COG1806 Cluster_579522 V1221525 YKOE S ABC superfamily ATP binding cassette transporter membrane protein COG4721 Cluster_475737 V1221526 PBP2B M penicillin-binding protein COG0768 Cluster_632871 V1221527 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_695910 V1221528 S NA 0Z0KI Cluster_385878 V1221529 S Inherit from NOG: Tail protein 11MY0 Cluster_632872 V1221531 K Bacterial regulatory proteins, tetR family COG1309 Cluster_427099 V1221532 map00230,map00983,map01100 F Glutamine amidotransferase COG0518 Cluster_339561 V1221535 map02010 P Nickel transport complex protein, NikM subunit, transmembrane 11GS3 Cluster_285930 V1221537 I Inherit from COG: acetyl-CoA carboxylase biotin carboxylase COG0439 Cluster_298184 V1221538 FADD map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG0318 Cluster_614105 V1221540 POTB map02010 P ABC transporter, permease COG1176 Cluster_414365 V1221541 POTA map02010 E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COG3842 Cluster_358764 V1221543 SSCG_01128 S secreted protein 124ZH Cluster_368628 V1221548 MELS_0665 L RNA-directed DNA polymerase (Reverse transcriptase) COG3344 Cluster_242535 V1221549 M Cell surface protein COG5295 Cluster_242536 V1221550 DLD map00620 C d-lactate dehydrogenase COG0277 Cluster_766228 V1221551 map00362,map01100,map01120 S domain protein COG1917 Cluster_419724 V1221557 COBL map00860,map01100 H Precorrin-6y C5,15-methyltransferase COG2242 Cluster_847976 V1221558 S Metallo-beta-lactamase superfamily COG0491 Cluster_318434 V1221559 ADHE2 map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map05204 C Dehydrogenase COG1062 Cluster_497114 V1221560 LEGAS_1040 L transposase COG2963 Cluster_560751 V1221561 UBIE map00340,map00350,map00624,map01120 Q methyltransferase COG0500 Cluster_243886 V1221565 M Inherit from NOG: Polymorphic outer membrane protein 11KKP Cluster_596102 V1221566 ARGS map00970 J arginyL-tRNA synthetase COG0018 Cluster_380566 V1221568 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_245160 V1221569 S NA 0ZHVH Cluster_302221 V1221570 DPPD E, P (ABC) transporter COG0444 Cluster_287336 V1221572 PYRC map00240,map01100 F dihydroorotase COG0044 Cluster_705358 V1221573 SCPA S Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) COG1354 Cluster_391148 V1221574 CMTA S Trehalose corynomycolyl transferase COG0627 Cluster_526077 V1221575 S AIPR protein 0ZFWF Cluster_269744 V1221577 PHOD map00627,map00790,map01100,map01120,map02020 P Alkaline phosphatase COG3540 Cluster_610457 V1221578 MIDI_00056 L Transposase 0YEAS Cluster_336578 V1221579 YPFJ S zinc metallopeptidase COG2321 Cluster_249053 V1221580 HELD map03420,map03430 L helicase COG3973 Cluster_246484 V1221581 PYC map00020,map00620,map00720,map01100,map01120,map01230 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) COG1038 Cluster_246485 V1221582 HEPA L Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) COG0553 Cluster_551904 V1221583 MT1668 S Protein of unknown function (DUF402) COG2306 Cluster_469343 V1221584 S NA 120AV Cluster_380567 V1221585 map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_796960 V1221590 SCLAV_1493 S NA 0XUCQ Cluster_528839 V1221591 SCLAV_1772 S chad domain containing protein 0YY54 Cluster_268399 V1221592 RV1481 S von Willebrand factor, type A COG2304 Cluster_247745 V1221593 DPNA L helicase COG4646 Cluster_606796 V1221594 RPLT map03010 J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) COG0292 Cluster_805098 V1221595 RPMI map03010 J 50s ribosomal protein L35 COG0291 Cluster_414366 V1221596 IRP6B map02010 P Iron chelate uptake ABC transporter, FeCT family, permease protein COG0609 Cluster_687567 V1221597 IRP6A map02010 P Periplasmic binding protein COG0614 Cluster_705359 V1221599 K, T phage shock protein C, PspC COG1983 Cluster_249054 V1221600 HEMD map00860,map01100,map01110 H synthase COG1587 Cluster_480358 V1221601 map00330,map01110,map01230 E Ornithine cyclodeaminase COG2423 Cluster_458865 V1221603 map03440 K Transcriptional regulator COG2865 Cluster_674161 V1221604 RFBA map00521,map00523,map01100,map01110 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) COG1209 Cluster_515160 V1221606 L transposase IS605 OrfB family 0XT7Q Cluster_250313 V1221607 ACTP P p-type atpase COG2217 Cluster_475738 V1221609 LPD map00010,map00020,map00260,map00280,map00620,map01100,map01110,map01120 C dihydrolipoyl dehydrogenase COG1249 Cluster_250314 V1221610 FADF C Fe-S oxidoreductase COG0247 Cluster_507289 V1221611 S Rib/alpha-like repeat 10008 Cluster_352059 V1221612 MTRA map02020 T response regulator COG0745 Cluster_250315 V1221615 ADH map00650 C Dehydrogenase COG1063 Cluster_250316 V1221616 TREB map00010,map00500,map00520,map02060 G phosphotransferase system, EIIB COG1264 Cluster_534416 V1221617 FCOL_03560 S NA 11YT4 Cluster_385879 V1221619 L Inherit from COG: transposase COG3666 Cluster_284488 V1221620 S Zinc finger, swim domain protein COG4279 Cluster_793017 V1221622 LEUC map00290,map00660,map01100,map01110,map01210,map01230 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) COG0065 Cluster_375288 V1221623 LTBR K Iclr family transcriptional regulator COG1414 Cluster_471490 V1221624 TERD T tellurium resistance protein COG2310 Cluster_251532 V1221626 SURB S G5 domain protein 0ZVV3 Cluster_589259 V1221630 RV0191 G integral membrane protein COG2814 Cluster_674162 V1221631 CAS2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) COG3512 Cluster_252747 V1221632 M NA 0YHI1 Cluster_252748 V1221634 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_434893 V1221637 PRIA map03440 L Primosomal protein n' COG1198 Cluster_252749 V1221638 ZWF map00030,map00480,map01100,map01110,map01120 G glucose-6-phosphate 1-dehydrogenase COG0364 Cluster_449017 V1221640 LEMA S LemA family COG1704 Cluster_458866 V1221642 PMT M glycosyl transferase, family 39 COG1928 Cluster_582759 V1221643 S Membrane COG5660 Cluster_657052 V1221644 HSDS V Restriction modification system DNA (Specificity COG0732 Cluster_687568 V1221646 L DNA methylase N-4 N-6 domain-containing protein COG1475 Cluster_268400 V1221649 S Inherit from NOG: domain protein 0XP4A Cluster_256441 V1221657 SURB S G5 domain protein 0ZVV3 Cluster_892142 V1221658 S NA 11IJN Cluster_458867 V1221659 C, O Pfam:DUF255 COG0526 Cluster_347329 V1221660 AARI_34710 L Transposase for insertion sequence 11IYJ Cluster_257732 V1221661 S radical SAM domain protein COG0535 Cluster_264352 V1221662 L Inherit from COG: Type II restriction enzyme, methylase COG1002 Cluster_796962 V1221664 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_450985 V1221665 CTAB map00190,map00860,map01100,map01110 O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) COG0109 Cluster_449018 V1221666 UBIA H Prenyltransferase COG0382 Cluster_603185 V1221667 I Membrane-associated phospholipid phosphatase COG0671 Cluster_256442 V1221668 GLGC map00500,map00520,map01100,map01110 G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) COG0448 Cluster_257733 V1221669 SCLAV_4759 L DNA helicase COG1112 Cluster_497115 V1221670 S NA 11R2V Cluster_526078 V1221671 PURA map00230,map00250,map01100 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis COG0104 Cluster_256443 V1221672 CSN1 L CRISPR-associated protein, Csn1 family COG3513 Cluster_582760 V1221675 IDSA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_528840 V1221676 MT2226 map00350,map00362,map00627,map00642,map00903,map01120 S Gcn5-related n-acetyltransferase COG0456 Cluster_871831 V1221681 YHFR K GntR Family Transcriptional Regulator COG2188 Cluster_365304 V1221682 D cobyrinic Acid a,c-diamide synthase COG1192 Cluster_596104 V1221684 COBT map00860,map01100 H Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) COG2038 Cluster_636901 V1221688 YLBL T Secreted protein COG3480 Cluster_330491 V1221691 S surface protein 11NE4 Cluster_259048 V1221695 ALDA map00010,map00040,map00053,map00071,map00280,map00281,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00626,map00640,map00903,map01100,map01110,map01120 C Aldehyde dehydrogenase family COG1012 Cluster_699185 V1221697 S NA 0ZD0C Cluster_847978 V1221701 S Flavin reductase like domain protein COG1853 Cluster_260353 V1221702 CLPA O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_648849 V1221703 RPLX map03010 J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) COG0198 Cluster_260354 V1221704 MT1814 V Hnh endonuclease 11XHB Cluster_408826 V1221705 S NA 0YHMP Cluster_728154 V1221706 S Membrane COG2860 Cluster_475739 V1221707 PYRF map00240,map01100 F orotidine 5''-phosphate decarboxylase COG0284 Cluster_566904 V1221708 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_632873 V1221711 RECO map03440 L Involved in DNA repair and RecF pathway recombination (By similarity) COG1381 Cluster_444951 V1221712 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_569983 V1221713 SP_1213 S Uncharacterized protein conserved in bacteria (DUF2130) COG4487 Cluster_261675 V1221715 LHR L helicase COG1201 Cluster_636902 V1221717 S mobilization protein 11J0G Cluster_260357 V1221718 RECQ map03018 L ATP-dependent DNA helicase RecQ COG0514 Cluster_260358 V1221721 DPNA L helicase COG4646 Cluster_465124 V1221722 PGPA map00564,map01100 I phosphatidylglycerophosphatase a COG1267 Cluster_365305 V1221724 TPN L transposase COG3316 Cluster_576415 V1221725 IRP6B map02010 P Iron chelate uptake ABC transporter, FeCT family, permease protein COG0609 Cluster_471491 V1221726 FECE map02010 P ABC transporter, ATP-binding protein COG1120 Cluster_589261 V1221727 DHAM G Dihydroxyacetone kinase COG3412 Cluster