Cluster_566081 V1000001 RPSI map03010 J 30S ribosomal protein S9 COG0103 Cluster_308979 V1000002 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_578689 V1000003 RPLQ map03010 J 50S ribosomal protein l17 COG0203 Cluster_239593 V1000004 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_572374 V1000005 RPSK map03010 J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) COG0100 Cluster_916651 V1000006 RPMJ map03010 J 50S ribosomal protein L36 COG0257 Cluster_740635 V1000007 INFA J however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) COG0361 Cluster_378421 V1000008 ADK map00230,map00240,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_522455 V1000009 RPLO map03010 J Binds to the 23S rRNA (By similarity) COG0200 Cluster_823744 V1000010 RPMD map03010 J 50S ribosomal protein L30 COG1841 Cluster_605875 V1000011 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_452466 V1000012 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_562868 V1000013 RPSH map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) COG0096 Cluster_595164 V1000014 RPLN map03010 J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) COG0093 Cluster_724090 V1000015 RPSQ map03010 J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal COG0186 Cluster_823745 V1000016 RPMC map03010 J 50s ribosomal protein l29 COG0255 Cluster_525339 V1000017 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_364903 V1000018 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_613186 V1000019 RPLV map03010 J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) COG0091 Cluster_704557 V1000020 RPSS map03010 J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) COG0185 Cluster_390768 V1000021 RPLC map03010 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 Cluster_673051 V1000022 RPSJ map03010 J Involved in the binding of tRNA to the ribosomes (By similarity) COG0051 Cluster_218189 V1000023 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_109296 V1000024 GLMU map00520,map01100,map01110 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) COG1207 Cluster_750662 V1000025 VEG S Veg protein COG4466 Cluster_261405 V1000026 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_430528 V1000027 RNMV L Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) COG1658 Cluster_313379 V1000028 TATD L Hydrolase, tatD family COG0084 Cluster_504128 V1000034 GREA2 K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) COG0782 Cluster_126642 V1000037 PEPC E aminopeptidase c COG3579 Cluster_149426 V1000038 YTTB G Major Facilitator 0ZVV9 Cluster_343780 V1000039 NRDG O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) COG0602 Cluster_32811 V1000040 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_343781 V1000041 GLPF G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) COG0580 Cluster_103300 V1000042 S M protein trans-acting positive regulator 11T9C Cluster_125280 V1000043 S oxidoreductase COG0446 Cluster_45525 V1000044 ASNB map00250,map00910,map01100,map01110,map01120 E asparagine synthetase COG0367 Cluster_491531 V1000046 T Universal stress protein COG0589 Cluster_300512 V1000047 PTP3 T protein tyrosine serine phosphatase COG2365 Cluster_272064 V1000048 K Transcriptional regulator 0Y1S3 Cluster_368272 V1000049 S NA 0Z3EH Cluster_98837 V1000050 S NA 11VH8 Cluster_272065 V1000051 K Inherit from COG: Transcriptional regulator COG1396 Cluster_327241 V1000052 CLVE map02010 S NA 11PT3 Cluster_419229 V1000053 S NA 0ZX1V Cluster_369947 V1000056 K transcriptional regulator 0ZMZA Cluster_219398 V1000057 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_374919 V1000058 S alpha beta COG0596 Cluster_297901 V1000059 EPSV M glycosyltransferase group 2 family protein COG0463 Cluster_378423 V1000060 map03030 S Caulimovirus viroplasmin COG3341 Cluster_75080 V1000061 GLNP E ABC transporter COG0834 Cluster_380127 V1000062 map00230,map00240,map00760,map01100,map01110 F UPF0207 protein COG1896 Cluster_258786 V1000063 HTPX map00900 O Protease HtpX homolog COG0501 Cluster_440476 V1000064 YKOE S ABC superfamily ATP binding cassette transporter membrane protein COG4721 Cluster_111916 V1000065 YKOD map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_162712 V1000066 HTRA O serine protease COG0265 Cluster_292333 V1000067 VICX map03013 S domain protein COG1235 Cluster_121261 V1000068 YYCH S YycH protein COG4863 Cluster_53005 V1000069 VICK map02020 T Histidine kinase 0XNMH Cluster_93196 V1000071 XASA E amino acid COG0531 Cluster_354987 V1000072 YFNB map00361,map00625,map01100,map01120 S Hydrolase COG1011 Cluster_519768 V1000073 NRDI F Probably involved in ribonucleotide reductase function (By similarity) COG1780 Cluster_49320 V1000074 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_591772 V1000075 RNPA J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) COG0594 Cluster_170975 V1000077 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_747298 V1000078 YAAA S S4 domain protein YaaA COG2501 Cluster_23553 V1000079 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_691077 V1000080 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_41483 V1000081 YYBT T domain protein COG3887 Cluster_111917 V1000082 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_161871 V1000083 SP_1634 S Protein of unknown function (DUF2974) 0XSVF Cluster_581900 V1000084 K Transcriptional regulator 0Y1S3 Cluster_147916 V1000085 G Major Facilitator 12APV Cluster_186258 V1000086 YUFN S basic membrane COG1744 Cluster_179312 V1000087 YUFP S ABC transporter (Permease COG4603 Cluster_381915 V1000088 DCK map00230,map00240,map01100 F deoxynucleoside kinase COG1428 Cluster_369948 V1000089 DCK map00230,map00240,map01100 F deoxynucleoside kinase COG1428 Cluster_126643 V1000090 PBUG S Xanthine uracil vitamin C permease COG2252 Cluster_167473 V1000091 S NA 11V0R Cluster_150272 V1000092 DLTB map05150 M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_29043 V1000093 DLTD map05150 M D-alanyl-lipoteichoic acid biosynthesis protein DltD COG3966 Cluster_605876 V1000094 S domain protein 11NZ4 Cluster_446523 V1000095 S NA 11H60 Cluster_406665 V1000097 LEPB map03060 U Signal peptidase i COG0681 Cluster_104454 V1000098 SUN map00340,map00350,map00624,map01120 J NOL1 NOP2 sun family protein COG0144 Cluster_190588 V1000099 MVAK2 map00900,map01100,map01110 I Phosphomevalonate kinase COG1577 Cluster_247479 V1000100 MVK map00900,map01100,map01110,map04146 I mevalonate kinase COG1577 Cluster_7646 V1000101 ADDB L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination COG3857 Cluster_6435 V1000102 ADDA L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation COG1074 Cluster_392559 V1000103 NTH map03410 L endonuclease III COG0177 Cluster_413945 V1000104 RECU S Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) COG3331 Cluster_446524 V1000105 YPSA S UPF0398 protein COG4474 Cluster_67437 V1000106 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_491532 V1000107 LSPA map03060 M, U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) COG0597 Cluster_456445 V1000108 HSLV O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) COG5405 Cluster_125954 V1000109 TRMFO J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) COG1206 Cluster_761252 V1000110 S UPF0346 protein COG4479 Cluster_277417 V1000111 ORF3 S degv family COG1307 Cluster_714178 V1000112 HUP L DNA-binding protein COG0776 Cluster_122684 V1000113 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_340702 V1000114 RLUB J Pseudouridine synthase COG1187 Cluster_334679 V1000115 SCPA S Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) COG1354 Cluster_58740 V1000116 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG3848 Cluster_244893 V1000117 RNZ map03013 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) COG1234 Cluster_47242 V1000118 OATA I Acyl-transferase COG1835 Cluster_364904 V1000119 SDAAB map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase, iron-sulfur-dependent, beta subunit COG1760 Cluster_415759 V1000120 ENGB S Necessary for normal cell division and for the maintenance of normal septation (By similarity) COG0218 Cluster_128738 V1000121 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_157617 V1000122 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_720713 V1000123 RPSO map03010 J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) COG0184 Cluster_737139 V1000124 RPST map03010 J Binds directly to 16S ribosomal RNA (By similarity) COG0268 Cluster_29280 V1000125 COMEC S Competence protein COG2333 Cluster_203713 V1000126 YLBL T domain protein COG3480 Cluster_475193 V1000127 COAD map00770,map01100 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) COG0669 Cluster_440477 V1000128 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_48927 V1000129 TYPA T gtp-binding protein typa COG1217 Cluster_389023 V1000130 S tpr repeat-containing protein 11U03 Cluster_473068 V1000131 FOLA map00670,map00790,map01100 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) COG0262 Cluster_29044 V1000132 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 Cluster_358403 V1000133 SRTA M (sortase) family COG3764 Cluster_440478 V1000134 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_660224 V1000135 J Ribosomal protein L7Ae/L30e/S12e/Gadd45 family COG1358 Cluster_691078 V1000136 YLXR K Nucleic-acid-binding protein implicated in transcription termination COG2740 Cluster_175971 V1000137 NUSA K Transcription elongation factor NusA COG0195 Cluster_454505 V1000138 RIMP S Required for maturation of 30S ribosomal subunits (By similarity) COG0779 Cluster_4071 V1000139 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_60898 V1000140 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_301926 V1000141 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_337731 V1000142 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_265390 V1000143 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_313380 V1000144 RPSB map03010 J 30S ribosomal protein S2 COG0052 Cluster_204827 V1000145 YABB map00340,map00350,map00624,map01120 L Methyltransferase COG4123 Cluster_59025 V1000146 MDLA map02010 V ABC transporter transmembrane region COG1132 Cluster_776485 V1000147 YNEF S UPF0154 protein COG3763 Cluster_417528 V1000148 LEXA K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) COG1974 Cluster_308980 V1000149 S NA 11Q2H Cluster_342171 V1000150 TRMD map00900,map01100,map01110 J Specifically methylates guanosine-37 in various tRNAs (By similarity) COG0336 Cluster_717451 V1000151 RPSP map03010 J 30s ribosomal protein S16 COG0228 Cluster_101025 V1000152 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_616926 V1000153 YLXM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) COG2739 Cluster_67093 V1000154 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_270768 V1000155 ISPA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_115406 V1000156 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_559995 V1000157 NUSB K Involved in the transcription termination process (By similarity) COG0781 Cluster_548207 V1000158 ASP S alkaline shock protein COG1302 Cluster_180149 V1000159 PEPP map00310,map00780,map01100 E peptidase M24 COG0006 Cluster_462529 V1000160 S response regulator receiver protein 1261B Cluster_328802 V1000161 YVFS map02010 V ABC transporter COG0842 Cluster_172686 V1000162 FOLP map00790,map01100 H dihydropteroate synthase COG0294 Cluster_408408 V1000163 F Ham1 family COG0127 Cluster_432526 V1000164 FOLE map00790,map01100 H GTP cyclohydrolase i COG0302 Cluster_635829 V1000165 FOLB map00790,map01100 H dihydroneopterin aldolase COG1539 Cluster_430529 V1000166 NUDF map00230 F nudix hydrolase COG0494 Cluster_779996 V1000167 CSPA K Cold shock protein COG1278 Cluster_13614 V1000168 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_6916 V1000169 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_363199 V1000170 RNC map03008,map05205 K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) COG0571 Cluster_60338 V1000171 OPPA E ABC transporter COG0747 Cluster_243615 V1000172 APPC map02010 P ABC superfamily ATP binding cassette transporter ABC protein COG1173 Cluster_41188 V1000173 RECG map03440 L ATP-dependent DNA helicase recG COG1200 Cluster_554065 V1000174 ASP S Alkaline-shock protein COG1302 Cluster_784290 V1000175 RPMB map03010 J 50S ribosomal protein l28 COG0227 Cluster_385450 V1000176 ARTM E amino acid AbC transporter COG0765 Cluster_285599 V1000177 GLNH map02010,map02020 E, T (ABC) transporter COG0834 Cluster_186259 V1000178 FRVX map00500,map01100 E Peptidase m42 family protein COG1363 Cluster_155117 V1000179 SBND G Major Facilitator 0ZVCH Cluster_125955 V1000180 PYRP F permease COG2233 Cluster_243616 V1000181 V abc transporter atp-binding protein COG1131 Cluster_319618 V1000182 SP_1071 S abc transporter atp-binding protein COG1101 Cluster_217069 V1000183 ATU2672 S ABC transporter COG2984 Cluster_150273 V1000184 S Bacteriophage peptidoglycan hydrolase 0ZNE8 Cluster_73773 V1000185 DEXB map00052,map00500,map01100 G trehalose-6-phosphate hydrolase (EC 3.2.1.93) COG0366 Cluster_356693 V1000186 map02010 P Cobalt transport protein COG0619 Cluster_403137 V1000187 SLGD_00062 S membrAne 11F2H Cluster_858365 V1000188 S NA 0ZG62 Cluster_33734 V1000194 S NA 1291J Cluster_39263 V1000195 M Minor structural protein 0XPF3 Cluster_12950 V1000196 S Inherit from NOG: Tail protein 11MY0 Cluster_668766 V1000197 S NA 0Z7IV Cluster_424731 V1000198 S tail protein 0Y1BD Cluster_140355 V1001803 ACIN_0074 L Transposase COG3464 Cluster_448546 V1001805 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_321060 V1001806 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_141829 V1001807 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_895371 V1001809 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_677532 V1001810 YRZB S UPF0473 protein COG3906 Cluster_542199 V1001811 RUVX L Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) COG0816 Cluster_724093 V1001812 YRZL S UPF0297 protein COG4472 Cluster_287024 V1001814 FBA map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01230 G fructose-bisphosphate aldolase COG0191 Cluster_213573 V1001815 INSI L transposase COG2826 Cluster_92273 V1001818 ADHE map00010,map00051,map00071,map00350,map00362,map00363,map00591,map00620,map00621,map00622,map00625,map00626,map00650,map01100,map01110,map01120 C Aldehyde-alcohol dehydrogenase 2 COG1454 Cluster_385453 V1001819 SITA map02010,map02020 P periplasmic solute binding protein COG0803 Cluster_288428 V1001820 SITC map02010,map02020 P ABC transporter COG1108 Cluster_232170 V1001821 S NA 0YIYD Cluster_194216 V1001822 PEPA map00500,map01100 E Peptidase m42 family protein COG1363 Cluster_136516 V1001824 PURB map00230,map00250,map01100,map01110 F adenylosuccinate lyase COG0015 Cluster_268089 V1001825 SDAA map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase COG1760 Cluster_784293 V1001826 PPAX map00190,map00230,map00240,map00630,map00760,map01100,map01110 S Hydrolase COG0546 Cluster_130984 V1001827 S tail tape measure protein COG5280 Cluster_850755 V1001828 S NA 0Z81M Cluster_496488 V1001829 GPSA map00564 C NADPH-dependent glycerol-3-phosphate dehydrogenase COG0240 Cluster_252461 V1001830 GALU map00040,map00052,map00500,map00520,map01100,map01110 M UTP-glucose-1-phosphate uridylyltransferase COG1210 Cluster_240891 V1001831 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate (By similarity) COG0167 Cluster_301931 V1001833 PTS-EIID map00051,map00520,map01100,map02060 G PTS System COG3716 Cluster_556946 V1001834 map00051,map00520,map01100,map02060 G PTS system fructose IIA component COG2893 Cluster_883156 V1001835 AGAS map00250,map00520,map01100,map01110 M isomerase COG2222 Cluster_247485 V1001836 S Domain of unknown function (DUF1837) 100DA Cluster_422966 V1001837 FOLP map00790,map01100 H dihydropteroate synthase COG0294 Cluster_278805 V1001838 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0302 Cluster_426616 V1001839 TATD L Hydrolase, tatD family COG0084 Cluster_891104 V1001840 RPMH map03010 J 50S ribosomal protein l34 COG0230 Cluster_466663 V1001841 S NA 12D34 Cluster_103301 V1001842 FUCA map00511 G Alpha-L-fucosidase COG3669 Cluster_272071 V1001843 DEGV S degv family COG1307 Cluster_466664 V1001844 YACP J Tetracycline resistance protein COG3688 Cluster_264043 V1001845 HUTU map00340,map01100 E Urocanate hydratase COG2987 Cluster_643819 V1001846 HUTI map00340,map01100 Q imidazolone-5-propionate hydrolase COG1228 Cluster_104458 V1001847 S Transglycosylase SLT domain COG5283 Cluster_397921 V1001848 VRAR map02020 T response regulator COG2197 Cluster_304852 V1001849 VRAS map02020 T Histidine kinase COG4585 Cluster_163524 V1001850 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_127350 V1001851 MALF map02010 P binding-protein-dependent transport systems inner membrane Component 0Y7BF Cluster_107505 V1001852 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG1640 Cluster_899481 V1001853 COMGB U Competence protein COG1459 Cluster_660226 V1001854 COMGC U comG operon protein 3 COG4537 Cluster_556947 V1001855 S NA 11EW3 Cluster_664447 V1001857 COMGF U comG operon protein 6 COG4940 Cluster_281441 V1001860 map00051,map00520,map01100,map02060 G PTS System COG3715 Cluster_506611 V1001861 LEVD map00051,map00520,map01100,map02060 G pts system COG3716 Cluster_479773 V1001862 SP_1785 S Protein of unknown function (DUF3013) 1289G Cluster_232171 V1001866 LYC M glycoside hydrolase, family 25 11T0J Cluster_289735 V1001867 DLTD map05150 M D-alanyl-lipoteichoic acid biosynthesis protein DltD COG3966 Cluster_754099 V1001868 DLTC map00473,map05150 H Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) COG0236 Cluster_677533 V1001869 DLTB map05150 M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_373220 V1001870 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_345389 V1001871 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_136517 V1001872 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_116880 V1001874 LLDP C L-lactate COG1620 Cluster_620693 V1001875 SP_0092 G extracellular solute-binding protein family 1 COG1653 Cluster_242244 V1001876 LPLC G Binding-protein-dependent transport systems, inner membrane component COG0395 Cluster_651939 V1001877 S Ion channel 1202Y Cluster_114045 V1001878 MNGB map00511 G hydrolase, family 38 COG0383 Cluster_191484 V1001879 ADH map00010,map00051,map00071,map00350,map00363,map00591,map00625,map00626,map00650,map00830,map00980,map00982,map01100,map01110,map01120 C alcohol dehydrogenase COG1063 Cluster_392562 V1001880 S NA 0YNCM Cluster_468841 V1001881 S NA 0Y2WH Cluster_448547 V1001882 I esterase COG0657 Cluster_295132 V1001883 LSA S (ABC) transporter COG0488 Cluster_117573 V1001884 ANSP E amino acid COG1113 Cluster_374924 V1001885 NTPJ P Potassium uptake protein COG0168 Cluster_369952 V1001886 KTRA P domain protein COG0569 Cluster_446528 V1001888 PGSA map00564,map01100 I cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase COG0558 Cluster_426617 V1001889 ECFA1 map02010 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates COG1122 Cluster_356699 V1001890 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_536611 V1001891 RPLK map03010 J This protein binds directly to 23S ribosomal RNA (By similarity) COG0080 Cluster_120456 V1001892 PFLB map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_883157 V1001893 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_178469 V1001894 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_371592 V1001895 YYBT T domain protein COG3887 Cluster_165186 V1001896 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_366647 V1001897 SDAAB map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase, iron-sulfur-dependent, beta subunit COG1760 Cluster_542200 V1001898 SDAA map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase COG1760 Cluster_717455 V1001899 GTF1 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) COG0438 Cluster_682095 V1001900 GATC map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0721 Cluster_750667 V1001901 GATA map00970,map01100 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) COG0154 Cluster_448548 V1001902 APF1 S Lysm domain protein 11U6T Cluster_126646 V1001903 S NA 0YA5W Cluster_491541 V1001905 S NA 0ZGFA Cluster_158500 V1001908 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_264044 V1001912 P cation diffusion facilitator family transporter COG1230 Cluster_701561 V1001913 K Bacterial regulatory proteins, tetR family COG1309 Cluster_146347 V1001914 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_166722 V1001915 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_328805 V1001916 SUFS map00450,map00730,map01100 E Cysteine desulfurase COG0520 Cluster_450526 V1001917 SUFD O feS assembly protein SufD COG0719 Cluster_691084 V1001918 J s4 domain protein COG1188 Cluster_595173 V1001919 DIVIC D Septum formation initiator COG2919 Cluster_835222 V1001922 METQ map02010 P Lipoprotein COG1464 Cluster_203715 V1001923 DAPE map00300,map01100,map01120,map01230 E peptidase COG0624 Cluster_214764 V1001924 map00860,map01100,map01110 S decarboxylase 11UPA Cluster_403140 V1001927 S NA 1269Y Cluster_165985 V1001928 YBIT S ABC transporter, ATP-binding protein COG0488 Cluster_189699 V1001929 GLGA map00500,map01100,map01110,map04973 G Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) COG0297 Cluster_823752 V1001930 GLGD map00500,map00520,map01100,map01110 M glucose-1-phosphate adenylyltransferase, glgd subunit COG0448 Cluster_265399 V1001931 PEPQ map00310,map00780,map01100 E peptidase M24 COG0006 Cluster_575626 V1001932 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_141830 V1001933 PCNA map03013,map03018 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate COG0617 Cluster_691085 V1001934 MANY map00051,map00520,map01100,map02060 G PTS System COG3715 Cluster_233466 V1001935 map00051,map00520,map01100,map02060 G component COG3444 Cluster_147922 V1001936 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_143326 V1001938 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_144807 V1001939 map00511 G glycoside hydrolase family 38 COG0383 Cluster_664448 V1001941 RV2901C S Protein of unknown function (DUF2469) 11N6F Cluster_151076 V1001942 S Transglycosylase SLT domain COG5283 Cluster_337737 V1001943 SUFC O feS assembly ATPase SufC COG0396 Cluster_161873 V1001944 SP_0341 S UPF0371 protein COG4868 Cluster_340713 V1001945 M Bacteriophage peptidoglycan hydrolase COG0791 Cluster_780002 V1001946 HOL S holin, phage phi LC3 family COG5546 Cluster_314985 V1001948 RNJB map03018 O Metallo-Beta-Lactamase COG0595 Cluster_545167 V1001949 ESTA S esterase COG0627 Cluster_269474 V1001950 S Phage portal protein 0XNRQ Cluster_562874 V1001952 SPXA_1 K transcriptional regulator, Spx COG1393 Cluster_522462 V1001953 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_765228 V1001954 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_157621 V1001955 YHGE S domain protein COG1511 Cluster_290997 V1001956 VEX3 V abc transporter permease protein COG0577 Cluster_585164 V1001957 VEX2 V abc transporter atp-binding protein COG1136 Cluster_232172 V1001959 NIST map02010 V ABC transporter 0XPIZ Cluster_940891 V1001960 SP_1785 S Protein of unknown function (DUF3013) 1289G Cluster_203716 V1001961 RARA L recombination factor protein RarA COG2256 Cluster_229842 V1001963 PURM map00230,map01100,map01110 F phosphoribosylaminoimidazole synthetase COG0150 Cluster_171788 V1001964 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_569187 V1001965 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_251281 V1001968 GLYQ map00970 J glycyl-tRNA synthetase, alpha subunit COG0752 Cluster_155122 V1001969 map00564 C glycerophosphoryl diester phosphodiesterase COG0584 Cluster_196776 V1001971 ADH map00010,map00051,map00071,map00350,map00363,map00591,map00625,map00626,map00650,map00830,map00980,map00982,map01100,map01110,map01120 C alcohol dehydrogenase COG1063 Cluster_200701 V1001972 S Transporter Permease Protein 0ZURF Cluster_237008 V1001975 NRNA J phosphoesterase RecJ domain protein COG0618 Cluster_710737 V1001976 FABG map00061,map00780,map01040,map01100 I reductase 0XNW1 Cluster_277424 V1001977 FABF map00061,map00780,map01100 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) COG0304 Cluster_180151 V1001978 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_293712 V1001979 DNAB L replication initiation and membrane attachment COG3611 Cluster_158501 V1001981 map00310,map00780,map01100 E Dipeptidase COG4690 Cluster_374925 V1001982 CYLA map02010 V ABC transporter, ATP-binding protein COG1131 Cluster_452476 V1001983 CYLB map02010 V Transporter COG0842 Cluster_181836 V1001984 GDH map00250,map00330,map00430,map00910,map01100 E Dehydrogenase COG2902 Cluster_509239 V1001986 ADCR K Transcriptional 0XUB6 Cluster_850757 V1001987 DUSB J Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_261408 V1001988 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_819616 V1001989 M glycosyl transferase COG1819 Cluster_162713 V1001990 CTPE P Cation-transporting atpase COG0474 Cluster_324183 V1001991 FOLK map00790,map01100 H 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase COG1539 Cluster_569188 V1001992 FOLE map00790,map01100 H GTP cyclohydrolase i COG0302 Cluster_664449 V1001993 TRXA2 O Thioredoxin COG0526 Cluster_525341 V1001994 BAES map02020 T Histidine kinase 0XNMH Cluster_336240 V1001995 RBSB map02010,map02030 G Ribose ABC transporter COG1879 Cluster_916655 V1001996 SP_0119 L Nudix family COG0494 Cluster_252462 V1001997 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_264045 V1001998 FBA map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01230 G Aldolase COG0191 Cluster_470947 V1001999 M Transglutaminase-like superfamily 0XV6Q Cluster_486733 V1002000 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_525409 V1019801 YEIH S Membrane COG2855 Cluster_174361 V1019803 S NA 11JF2 Cluster_68487 V1019812 S NA 0ZHU8 Cluster_134931 V1019813 S tonB-dependent Receptor 0XNVP Cluster_424777 V1019814 PURN map00230,map00670,map01100,map01110 F phosphoribosylglycinamide formyltransferase COG0299 Cluster_306284 V1019815 S Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) COG1385 Cluster_698503 V1019816 S NA 0Z4BV Cluster_517238 V1019817 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_157642 V1019818 map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aminotransferase COG0436 Cluster_157643 V1019819 map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aminotransferase COG0436 Cluster_522521 V1019822 DPS P DNA protection during starvation protein COG0783 Cluster_557006 V1019823 S Protein of unknown function, DUF393 COG3011 Cluster_299209 V1019825 AROK map00400,map01100,map01110,map01230 E Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) COG0703 Cluster_77060 V1019827 NIKA map02010 E Nickel ABC transporter, periplasmic nickel-binding protein COG0747 Cluster_381952 V1019830 SP_1047 S NA 128UG Cluster_237051 V1019831 S Recombinase 0Y2JQ Cluster_403184 V1019832 RECR map03440 L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) COG0353 Cluster_162738 V1019833 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_128756 V1019834 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_714225 V1019835 CCU S Protein of unknown function (DUF1643) COG4333 Cluster_647914 V1019836 ORF010 S Staphylococcal protein of unknown function (DUF960) 1265C Cluster_303364 V1019838 L Resolvase COG1961 Cluster_812208 V1019841 YVLC S phage shock protein C, PspC COG1983 Cluster_186290 V1019845 YBHE S Outer surface protein COG3589 Cluster_530979 V1019846 NAGK G BadF BadG BcrA BcrD COG2971 Cluster_141149 V1019856 DCM2 map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_56425 V1019857 RPSA map00900,map01100,map01110,map03010 J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) COG0539 Cluster_163545 V1019858 ACDH map00071,map00280,map00281,map00650,map01100,map01110 I acyl-CoA dehydrogenase COG1960 Cluster_444546 V1019859 I MaoC like domain COG2030 Cluster_43105 V1019860 S NA 0YZ82 Cluster_270812 V1019863 REP L Replication Protein COG5527 Cluster_237052 V1019864 map00270,map00920,map01100,map01120,map01230 E serine O-acetyltransferase (EC 2.3.1.30) COG1045 Cluster_227534 V1019865 S DNA polymerase iii 101FB Cluster_509295 V1019866 P uptake regulation protein COG0735 Cluster_486775 V1019867 P sulfate transporter COG0659 Cluster_444547 V1019868 OCAR_4628 S HhH-GPD domain protein COG5483 Cluster_506666 V1019869 C Luciferase-like monooxygenase COG2141 Cluster_356748 V1019870 GLNR K transcriptional regulator COG0745 Cluster_366685 V1019871 S NA 11TYD Cluster_43282 V1019873 SASC S surface protein 11FPX Cluster_141847 V1019874 CCSB O Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) COG1333 Cluster_337793 V1019876 map02020 T regulator COG0745 Cluster_714226 V1019878 MOAA map00790,map01100,map04122 H Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) COG2896 Cluster_196792 V1019879 MOEB map00730,map01100,map04122 H uba thif-type nad fad binding protein COG0476 Cluster_468884 V1019880 MOAE map00790,map01100,map04122 H molybdopterin converting factor, large subunit COG0314 Cluster_203743 V1019885 KDPD map02020 T Histidine kinase COG2205 Cluster_353439 V1019886 KDPE map02020 T response regulator COG0745 Cluster_225293 V1019893 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_598850 V1019894 MOAB map00790,map01100,map04122 H Molybdenum cofactor synthesis domain protein COG0521 Cluster_765281 V1019895 S ThiS family 1026U Cluster_56731 V1019896 YFMR S ABC transporter, ATP-binding protein COG0488 Cluster_102156 V1019899 HSDM V type I restriction-modification system COG0286 Cluster_157644 V1019901 KBL map00260,map00780,map01100 E 2-amino-3-ketobutyrate coenzyme A ligase COG0156 Cluster_581974 V1019902 S conserved domain protein 0YM94 Cluster_545233 V1019904 K Transcriptional regulator, arsr family COG0640 Cluster_385503 V1019906 M Teichoic acid COG1887 Cluster_174362 V1019907 MNAA map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_346969 V1019908 S Beta-lactamase domain protein COG0491 Cluster_452513 V1019910 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_434457 V1019911 S NA 11ST2 Cluster_450558 V1019912 S Gtra family COG2246 Cluster_179342 V1019917 map00860,map01100 H cobaltochelatase, cobn subunit COG1429 Cluster_440525 V1019918 GPO map00480,map00590 O Glutathione peroxidase COG0386 Cluster_560059 V1019919 HYPA C Hydrogenase nickel incorporation protein COG0375 Cluster_284219 V1019921 MODF map02010 P ABC transporter COG1119 Cluster_413985 V1019922 COPA map00053,map01100 Q Multicopper oxidase COG2132 Cluster_288459 V1019923 SOJ D Chromosome Partitioning Protein COG1192 Cluster_134932 V1019924 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_578754 V1019926 GLPE P rhodanese-like protein COG0607 Cluster_501732 V1019927 S doxx family 0ZX2M Cluster_64788 V1019929 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_235868 V1019930 S alpha beta COG4757 Cluster_186291 V1019932 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_270813 V1019933 S NA 11MMW Cluster_554123 V1019935 HELY L helicase COG4581 Cluster_166007 V1019936 TATC map03060,map03070 U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) COG0805 Cluster_78720 V1019937 M Nlp p60 protein COG0791 Cluster_714228 V1019938 S NA 0ZHU9 Cluster_714229 V1019941 S NA 0ZHU9 Cluster_412065 V1019944 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_473117 V1019945 K lytTr DNA-binding domain protein 11WH8 Cluster_291043 V1019946 GPMB map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_588473 V1019949 YDII Q thioesterase Superfamily protein COG2050 Cluster_412066 V1019950 RPLY map03010 J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) COG1825 Cluster_200719 V1019951 NUSB K Involved in the transcription termination process (By similarity) COG0781 Cluster_397949 V1019952 TAG map03410 L Dna-3-methyladenine glycosylase i COG2818 Cluster_248822 V1019953 PANE map00770,map01100,map01110 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) COG1893 Cluster_581975 V1019954 S NA 0YIA5 Cluster_134120 V1019955 S Relaxase mobilization nuclease 0Y9PG Cluster_438549 V1019956 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_624487 V1019957 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_450559 V1019958 S NA 0YNFS Cluster_309015 V1019960 S Short chain dehydrogenase 11FE9 Cluster_361651 V1019961 ALKB L Alkylated DNA repair protein COG3145 Cluster_121273 V1019962 PEPC E aminopeptidase c COG3579 Cluster_118272 V1019963 U relaxase mobilization nuclease domain protein COG3843 Cluster_151088 V1019964 BMA1016 L transposase, IS204 IS1001 IS1096 IS1165 family protein COG3464 Cluster_816044 V1019965 S NA 0Z4XG Cluster_835265 V1019966 S YcfA-like protein 0ZAAU Cluster_470989 V1019967 S NA 0XWCR Cluster_765282 V1019968 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_199686 V1019969 NREB map02020 T Sensor histidine kinase 0XNMH Cluster_511882 V1019970 NREA map02020 S of nitrate reduction 11WUR Cluster_616992 V1019971 RPLU map03010 J This protein binds to 23S rRNA in the presence of protein L20 (By similarity) COG0261 Cluster_743917 V1019972 RPMA map03010 J 50S ribosomal protein l27 COG0211 Cluster_325724 V1019973 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_442548 V1019977 K regulatoR 0Y2NF Cluster_572438 V1019980 FDHD C Necessary for formate dehydrogenase activity (By similarity) COG1526 Cluster_333238 V1019981 T regulatoR 11ZQF Cluster_234679 V1019982 S ATPase domain protein 125CS Cluster_440526 V1019983 NUDF map00230 F nudix hydrolase COG0494 Cluster_121998 V1019984 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG0469 Cluster_300547 V1019985 GG9_0942 L transposase COG2801 Cluster_423002 V1019986 L Transposase 11M0T Cluster_591847 V1019987 YGDD S Membrane COG2363 Cluster_378471 V1019989 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_187169 V1019990 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_309016 V1019991 LPXA map00540,map01100 M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) COG1043 Cluster_598851 V1019992 SECG map03060,map03070 U Preprotein translocase SecG subunit 123GJ Cluster_192439 V1019993 ARGF map00330,map01100,map01110,map01230 E ornithine carbamoyltransferase COG0078 Cluster_171000 V1019994 M Glycosyl transferase, family 2 0ZNJT Cluster_46885 V1019997 L helicase COG4646 Cluster_117587 V1019998 YDIU S UPF0061 protein COG0397 Cluster_470990 V1019999 SGLY_0535 S phage protein 0XNW6 Cluster_711464 V1199802 YAFQ S addiction module toxin, RelE StbE family COG3041 Cluster_103417 V1199803 S NA 0XZ3T Cluster_330472 V1199804 S phage tail component 0Z5R7 Cluster_46353 V1199805 S tail tape measure protein COG5280 Cluster_487234 V1199806 S NA COG5412 Cluster_410658 V1199808 S NA 102R7 Cluster_224318 V1199811 S Structural protein 11PKS Cluster_391122 V1199813 S NA 11QJS Cluster_143461 V1199814 S NA 12BGZ Cluster_94684 V1199815 S Phage portal protein, SPP1 Gp6-like 11J8D Cluster_606717 V1199816 V Hnh endonuclease COG1403 Cluster_537270 V1199820 RUSA L endodeoxyribonuclease RusA COG4570 Cluster_430929 V1199822 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_352040 V1199823 BET L Phage recombination protein Bet 11G2M Cluster_312246 V1199825 K anti-repressor COG3645 Cluster_358742 V1199829 K HTH_XRE 0XUC3 Cluster_189873 V1199832 L Phage integrase COG0582 Cluster_2074 V1199833 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_17140 V1199834 XYLS map00052,map00500,map01100 G hydrolase, family 31 COG1501 Cluster_294015 V1199835 S TraX protein 100CF Cluster_64573 V1199836 MALL map00500,map01100 G Oligo-1-6-glucosidase COG0366 Cluster_30713 V1199837 MALQ map00500,map01100 G 4-alpha-glucanotransferase COG1640 Cluster_285909 V1199838 map02010 P ABC transporter COG0395 Cluster_100552 V1199839 AMYE map02010 G solute-binding protein COG1653 Cluster_363541 V1199840 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_86816 V1199841 P Chloride channel COG0038 Cluster_285910 V1199842 METQ map02010 P lipoprotein COG1464 Cluster_1723 V1199844 S NA 0YG6V Cluster_287312 V1199845 SUHB map00521,map00562,map01100,map01110,map04070 G inositol monophosphatase COG0483 Cluster_66854 V1199846 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_9180 V1199847 CAFA map03018 J ribonuclease COG1530 Cluster_101695 V1199849 D Maf-like protein COG0424 Cluster_110048 V1199850 HOM map00260,map00270,map00300,map01100,map01110,map01120,map01230 E homoserine dehydrogenase COG0460 Cluster_171140 V1199851 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_6683 V1199852 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_131886 V1199853 RUTG F permease COG2233 Cluster_322938 V1199854 SCLAV_2398 T response regulator COG2197 Cluster_327573 V1199856 YBHL S Membrane COG0670 Cluster_210465 V1199857 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_69600 V1199858 LMRB P drug resistance transporter, EmrB QacA subfamily 0XNN3 Cluster_239868 V1199859 RIHB map00230,map00240,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_417925 V1199860 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_252732 V1199861 TRMD map00900,map01100,map01110 J Specifically methylates guanosine-37 in various tRNAs (By similarity) COG0336 Cluster_408798 V1199862 RIMM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) COG0806 Cluster_73146 V1199863 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_96281 V1199864 PEPC E aminopeptidase c COG3579 Cluster_84711 V1199866 ULAA map00053,map01100,map01120,map02060 G PTS system ascorbate-specific transporter subunit IIC COG3037 Cluster_705253 V1199867 map00053,map01100,map01120,map02060 G IIb component COG3414 Cluster_69601 V1199868 PTSI map02060 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) COG1080 Cluster_13918 V1199869 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG1754 Cluster_161198 V1199870 S PAP2 superfamily 0XZ0P Cluster_283097 V1199871 MRAZ S Cell division protein mraZ COG2001 Cluster_182070 V1199872 RLUD J Pseudouridine synthase COG0564 Cluster_172866 V1199873 TRMI J tRNA (Adenine-N1-)-methyltransferase COG2519 Cluster_288670 V1199874 YEAZ O Peptidase M22 Glycoprotease COG1214 Cluster_54995 V1199875 map02010 G ABC transporter COG4213 Cluster_57269 V1199876 RHLE map03018 L Helicase COG0513 Cluster_73852 V1199877 S Membrane COG0628 Cluster_566833 V1199878 CPIN_3686 L Transposase (IS4 family COG3385 Cluster_218453 V1199880 S NA 10255 Cluster_164483 V1199881 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG0582 Cluster_173706 V1199882 TYRA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydrogenase COG0287 Cluster_25412 V1199885 PRIA map03440 L Primosomal protein n' COG1198 Cluster_151210 V1199886 AROE map00400,map01100,map01110,map01230 E shikimate COG0169 Cluster_207224 V1199887 YHBJ S Displays ATPase and GTPase activities (By similarity) COG1660 Cluster_283098 V1199888 S haloacid dehalogenase-like hydrolase COG0561 Cluster_72817 V1199889 map03440 K Transcriptional regulator 0XRI9 Cluster_95696 V1199890 S atpase, aaa COG1373 Cluster_94685 V1199891 SLGD_00086 S Ser Thr phosphatase family protein COG1409 Cluster_773494 V1199892 S helix-turn-helix domain protein 122WR Cluster_275046 V1199893 map03430 L Dna adenine methylase COG0338 Cluster_60387 V1199894 V ATPase associated with various cellular activities aaa_5 COG1401 Cluster_62897 V1199896 M Inherit from NOG: Lpxtg-motif cell wall anchor domain protein 0Y6CS Cluster_5318 V1199898 L DNA helicase COG1112 Cluster_100553 V1199899 PEPC E aminopeptidase c COG3579 Cluster_339 V1199900 S NA 101UU Cluster_196951 V1199901 ISPE map00900,map01100,map01110 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COG1947 Cluster_58794 V1199902 S integral membrane protein 0XS1S Cluster_475695 V1199908 S NA 123H2 Cluster_12252 V1199910 D cell division protein FtsK COG1674 Cluster_178613 V1199911 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_95201 V1199912 PIP map00330 L Prolyl aminopeptidase COG0596 Cluster_122145 V1199913 S NA 11FSG Cluster_824547 V1199914 S YcfA-like protein 0XX5U Cluster_4693 V1199917 S NA 11RGQ Cluster_392936 V1199919 S integral membrane protein COG4243 Cluster_72818 V1199920 MPHA S Aminoglycoside phosphotransferase 0YEJ0 Cluster_105181 V1199921 S DivIVA domain repeat protein 11XZ2 Cluster_85908 V1199922 GLYQS map00970 J Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) COG0423 Cluster_96282 V1199923 MVAA map00900,map01100,map01110,map04976 I hydroxymethylglutaryL-CoA reductase COG1257 Cluster_11575 V1199924 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_444925 V1199925 S NA 1AK94@sphNOG Cluster_98960 V1199928 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_227750 V1199929 APPB map02010 P Binding-protein-dependent transport systems inner membrane component COG0601 Cluster_16058 V1199931 map00760,map01100 H NAD synthase 1215K Cluster_628978 V1199932 XSEB map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) 121U6 Cluster_180314 V1199933 M Sortase family COG3764 Cluster_63742 V1199934 M Inherit from NOG: Lpxtg-motif cell wall anchor domain protein 0Y6CS Cluster_1891 V1199935 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_176118 V1199936 M Sortase family COG3764 Cluster_823 V1199937 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_327574 V1199938 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_201871 V1199939 DNAJ1 O DnaJ domain protein COG2214 Cluster_557623 V1199940 S kila-n, DNA-binding domain 0XPNQ Cluster_9302 V1199942 S NA 1278K Cluster_10329 V1199944 S NA 12BGB Cluster_231247 V1199945 XERD L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_473570 V1199946 YBAK S YbaK ebsC protein COG2606 Cluster_55492 V1199947 MURE map00300,map00550,map01100 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_77122 V1199948 PEPP E Xaa-Pro aminopeptidase COG0006 Cluster_257704 V1199949 map00051,map00500,map00520,map01100 G pfkb domain protein COG0524 Cluster_246468 V1199951 PLSC2 map00561,map00564,map01100 I Acyl-transferase COG0204 Cluster_199875 V1199952 THRB map00260,map01100,map01120,map01230 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) COG0083 Cluster_91856 V1199953 D Maf-like protein COG0424 Cluster_678501 V1199955 YHBY J Rna-binding protein COG1534 Cluster_25307 V1199956 RV2326C map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_70886 V1199957 PCCB map00280,map00630,map00640,map00720,map01100,map01120 I carboxyl transferase COG4799 Cluster_279048 V1199958 GLNR K transcriptional regulator COG0745 Cluster_162028 V1199959 map00051 M glycosyltransferase group 2 family protein COG0463 Cluster_135871 V1199960 S Virulence-associated protein e COG5545 Cluster_48314 V1199962 MOD map00340,map00350,map00624,map01120 L DNA methylase COG2189 Cluster_440925 V1199963 SCLAV_4550 L UPF0102 protein COG0792 Cluster_45359 V1199964 SDHA map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map05134 C Succinate dehydrogenase (Flavoprotein subunit) COG1053 Cluster_336559 V1199965 K GntR Family Transcriptional Regulator COG2188 Cluster_21848 V1199966 S domain protein 0YF83 Cluster_648765 V1199967 S Addiction module antitoxin, RelB DinJ family 11X3K Cluster_27887 V1199969 SCLAV_2282 M Peptidoglycan binding domain protein COG3409 Cluster_394740 V1199970 S NA 11WGF Cluster_350541 V1199971 TRML map04122 J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) COG0219 Cluster_387689 V1199972 NTH map03410 L endonuclease III COG0177 Cluster_227751 V1199974 AQPZ G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) COG0580 Cluster_32704 V1199975 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_21402 V1199976 L HELICc COG4581 Cluster_678502 V1199978 YHBY J Rna-binding protein COG1534 Cluster_27177 V1199979 RV2326C map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_427074 V1199980 S Membrane COG3601 Cluster_139771 V1199982 PHOH T Phoh family COG1702 Cluster_318408 V1199984 S Membrane 11NPN Cluster_54749 V1199985 HHOA map02020 O Peptidase s1 and s6 chymotrypsin hap COG0265 Cluster_81341 V1199987 SCLAV_4061 S Uncharacterised conserved protein (DUF2342) COG5282 Cluster_253987 V1199988 YLBL T Secreted protein COG3480 Cluster_85909 V1199989 S DivIVA domain repeat protein 11XZ2 Cluster_303652 V1199990 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_167668 V1199991 DUSB J Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_292638 V1199992 TRMB C Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_342515 V1199993 S abc transporter atp-binding protein COG4721 Cluster_133471 V1199994 map00561,map01100 M group 1 glycosyl transferase COG0438 Cluster_542935 V1199995 RV2923C O OsmC family COG1765 Cluster_440926 V1199996 WZB T protein tyrosine phosphatase COG0394 Cluster_281697 V1199997 RV2219 S integral membrane protein 0Z3WW Cluster_26367 V1199998 METE map00270,map00450,map01100,map01110,map01230 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) COG0620 Cluster_889 V1199999 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_9783 V1200000 GLNE O, T Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) COG1391 Cluster_391123 V1200002 S NA 0Y0MV Cluster_103418 V1200003 M polysaccharide biosynthesis protein COG2244 Cluster_3983 V1200004 UVRD2 map03420,map03430 L helicase COG0210 Cluster_207225 V1200006 RBSK map00030 G ribokinase COG0524 Cluster_166137 V1200007 M Sortase family COG3764 Cluster_55493 V1200008 M Cell wall anchor domain protein 11Q8J Cluster_39144 V1200011 YFMR S abc transporter COG0488 Cluster_12794 V1200012 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG1754 Cluster_277686 V1200013 I esterase COG0657 Cluster_656954 V1200014 S toxin-antitoxin system, antitoxin component, ribbon-helix-helix 11U5W Cluster_405353 V1200015 CLOSA_0730 V Hnh endonuclease COG1479 Cluster_199876 V1200016 L DNA methylase n-4 n-6 domain protein COG0863 Cluster_261656 V1200017 CFR9IM L DNA Methylase COG0863 Cluster_820506 V1200018 S NA 0Z3DG Cluster_309268 V1200019 S NA 0ZW0F Cluster_339538 V1200020 S NA 0XTII Cluster_656955 V1200021 S NA COG4694 Cluster_683049 V1200022 S NA 0ZXAM Cluster_177779 V1200023 S Inherit from COG: virion core protein (Lumpy skin disease COG4260 Cluster_385845 V1200024 S NA 0Y2P8 Cluster_839791 V1200026 MSRA S methionine sulfoxide reductase A 0YJ5R Cluster_695820 V1200027 MSRA S methionine sulfoxide reductase A 0YJ5R Cluster_421494 V1200028 S NA 0Y0MV Cluster_780925 V1200029 S NA 127RR Cluster_202923 V1200031 BL02849 S Baat aCyl-coa thioester hydrolase COG1073 Cluster_138231 V1200033 S Peptidoglycan-binding domain 1 protein 0ZWAS Cluster_315315 V1200034 PHNL3 V Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) COG1136 Cluster_166874 V1200035 SCLAV_2953 V (ABC) transporter COG0577 Cluster_251523 V1200036 S ABC transporter substrate-binding protein 0ZK3U Cluster_37487 V1200037 S TPR repeat-containing protein COG0457 Cluster_330473 V1200038 map00361,map00625,map01100,map01120 S had-superfamily hydrolase, subfamily ia, variant COG1011 Cluster_35044 V1200039 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_175325 V1200040 RLMB J RNA methyltransferase TrmH family group 3 COG0566 Cluster_194410 V1200042 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_73853 V1200043 map02010 S ABC transporter COG1123 Cluster_239869 V1200044 PDXS map00750 H Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) COG0214 Cluster_405354 V1200045 PDXT map00750 H Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) COG0311 Cluster_289966 V1200047 PFLA O Pyruvate formate-lyase COG1180 Cluster_389398 V1200049 I phosphoesterase PA-phosphatase related protein COG0671 Cluster_480320 V1200050 PTH J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) COG0193 Cluster_363 V1200051 S NA 0ZTYV Cluster_14077 V1200052 CAS3 L CRISPR-associated helicase, cas3 COG1203 Cluster_69602 V1200053 CASA L crispr-associated protein 0XPA1 Cluster_401763 V1200054 CASB S CRISPR system CASCADE complex protein CasB 0ZXJT Cluster_266974 V1200055 CAS5E L crispr-associated protein 11JEJ Cluster_375266 V1200056 CASE L crispr-associated protein 0XPHC Cluster_714848 V1200057 map00350,map00362,map00627,map00642,map00903,map01120 S acetyltransferase, (GNAT) family COG3981 Cluster_656956 V1200058 S NA 1228P Cluster_731335 V1200060 MUTT L mutator MutT protein COG0494 Cluster_51737 V1200061 S Uncharacterized conserved protein (DUF2075) 0XPB6 Cluster_828394 V1200062 S NA 11SAZ Cluster_648767 V1200063 S NA 11SAZ Cluster_322939 V1200064 V NA 0Y1U9 Cluster_751414 V1200065 S NA 0YK5G Cluster_51321 V1200066 M Inherit from NOG: Lpxtg-motif cell wall anchor domain protein 0Y6CS Cluster_785099 V1200070 S NA 1AQGC@spiNOG Cluster_97347 V1200071 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_116 V1200072 S NA 0YZ82 Cluster_387690 V1200073 TMK map00240,map01100 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) COG0125 Cluster_313729 V1200074 map03060,map03070 U sec-independent protein 0ZXQT Cluster_98429 V1200075 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_121382 V1200077 VEX1 V ABC transporter, permease COG0577 Cluster_27689 V1200078 S NA 11FZK Cluster_189874 V1200079 S NA 11K9E Cluster_51917 V1200080 P periplasmic solute binding protein COG0803 Cluster_26257 V1200081 map00550,map01100 M glycosyl transferase, family 51 COG0744 Cluster_196952 V1200082 DNAJ1 O DnaJ domain protein COG2214 Cluster_344094 V1200083 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_48315 V1200084 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_335023 V1200085 MOEB map00730,map01100,map04122 H uba thif-type nad fad binding protein COG0476 Cluster_318409 V1200086 THIO map00730 E glycine oxidase COG0665 Cluster_97348 V1200087 Y2366 V ABC transporter, permease COG0577 Cluster_17972 V1200090 S Lipase (class 3) 0ZJUJ Cluster_242518 V1200091 S NA 11IEF Cluster_347295 V1200092 NANE map00520 G Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) COG3010 Cluster_243864 V1200093 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_116987 V1200094 PHOR map02020 T Histidine kinase 0XNMH Cluster_101696 V1200096 P Chloride channel COG0038 Cluster_728037 V1200098 H thiF family COG0476 Cluster_224319 V1200100 S Endonuclease Exonuclease phosphatase 0XPGG Cluster_295423 V1200101 L resolvase COG1961 Cluster_29894 V1200103 S NA 0ZUUB Cluster_32705 V1200104 LKTB3 V ABC transporter, ATP-binding protein COG2274 Cluster_133472 V1200105 S radical SAM domain protein COG0641 Cluster_39145 V1200106 S NA 0ZSEH Cluster_133473 V1200107 S Inherit from COG: ATPase (AAA COG1373 Cluster_220799 V1200109 K Transcriptional regulator (XRE family 0ZJRR Cluster_342516 V1200111 map00361,map00625,map01100,map01120 S had-superfamily hydrolase, subfamily ia, variant COG1011 Cluster_230077 V1200112 NNRD G carbohydrate kinase, YjeF related protein COG0063 Cluster_230078 V1200113 RNHA map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0328 Cluster_352041 V1200114 RPIA map00030,map00710,map01100,map01110,map01120,map01230 G phosphoriboisomerase A COG0120 Cluster_504665 V1200115 U TraG family COG3505 Cluster_238596 V1200116 L Integrase core domain protein COG2801 Cluster_499727 V1200123 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_37950 V1200124 V permease 0YATZ Cluster_448979 V1200125 QUEF map00790,map01100 S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) COG0780 Cluster_628979 V1200126 S mobilization protein 11J0G Cluster_108174 V1200127 VIRE L Virulence-associated protein e COG5545 Cluster_176119 V1200128 L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) COG0582 Cluster_751415 V1200129 S NA 186YM@proNOG Cluster_523094 V1200130 S HTH_XRE 11ZMP Cluster_68557 V1200131 T Serine Threonine protein kinase COG0515 Cluster_21403 V1200132 L HELICc COG4581 Cluster_103992 V1200133 PYRC map00230,map00240,map01100,map01120 F dihydroorotase COG0044 Cluster_208342 V1200134 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate (By similarity) COG0167 Cluster_355375 V1200135 PYRE map00240,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_33387 V1200136 MALQ map00500,map01100 G 4-alpha-glucanotransferase COG1640 Cluster_363542 V1200137 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_656957 V1200138 MJLS_4465 S protein, conserved in bacteria COG1937 Cluster_162877 V1200139 map02010 V ABC-2 type transporter COG0842 Cluster_766074 V1200140 S NA 0YQAH Cluster_1769 V1200144 S NA 11NI8 Cluster_8335 V1200145 YLBB V abc transporter permease protein COG0577 Cluster_283099 V1200146 S haloacid dehalogenase-like hydrolase COG0561 Cluster_174508 V1200147 MVAD map00900,map01100,map01110 I diphosphomevalonate decarboxylase COG3407 Cluster_22436 V1200148 FNI map00900,map01100,map01110 C Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) COG1577 Cluster_348923 V1200151 map02010 P Cobalt transport protein COG0619 Cluster_70233 V1200152 S NA 0YK1E Cluster_324510 V1200153 S Phage replisome organizer 0ZW0Q Cluster_14743 V1200154 S Lipase (class 3) 0ZJUJ Cluster_259031 V1200155 L Dna topoisomerase COG0550 Cluster_135059 V1200157 L Integrase 0YTFQ Cluster_573130 V1200158 M peptidase, S41 COG0793 Cluster_272367 V1200159 TRPC map00400,map01100,map01110,map01230 E Indole-3-glycerol phosphate synthase COG0134 Cluster_789080 V1200160 S NA 125T8 Cluster_119886 V1200162 RMUC S Dna recombination protein COG1322 Cluster_174509 V1200164 S phage protein 0XQDU Cluster_699103 V1200165 S rRNA biogenesis protein Rrp5 0XUK3 Cluster_247733 V1200166 M hydrolase, family 25 COG3757 Cluster_84280 V1200168 PUTP E Sodium proline symporter COG0591 Cluster_192587 V1200170 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_428964 V1200171 G Alpha-1,2-mannosidase COG3537 Cluster_1757 V1200172 S NA 0YZ82 Cluster_259032 V1200173 S repeat protein 0ZY5G Cluster_540072 V1200175 NIKR K Transcriptional regulator (By similarity) COG0864 Cluster_305154 V1200176 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_306542 V1200177 YLME F alanine racemase domain protein COG0325 Cluster_171961 V1200178 GLUQ map00860,map00970,map01100,map01110 J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) COG0008 Cluster_335024 V1200179 GLPF G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) COG0580 Cluster_201872 V1200180 S DNA-binding protein COG3943 Cluster_708381 V1200181 S lysozyme 0YC6U Cluster_419693 V1200182 TRAO S conjugative transposon protein TraO 0YB3M Cluster_230079 V1200183 TRAN S Conjugative transposon TraN protein 0XNQ2 Cluster_569924 V1200184 PGN_0971 L Transposase, is4 family COG3039 Cluster_249036 V1200185 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_523095 V1200186 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_74481 V1200187 J NOL1/NOP2/sun family COG0144 Cluster_223143 V1200188 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_338096 V1200190 S RumE protein 0Z8VP Cluster_167669 V1200191 NAGA map00052,map00520,map01110 G GlcNAc 6-P deacetylase COG1820 Cluster_27178 V1200192 S NA 11FZK Cluster_154445 V1200193 S NA 11K9E Cluster_467171 V1200194 MRAZ S Cell division protein mraZ COG2001 Cluster_90908 V1200195 ABFD map00350,map00650,map00720,map01120 Q 4-hydroxyphenylacetate COG2368 Cluster_303653 V1200198 SUSC P outer membrane protein SusC 0XNNV Cluster_73854 V1200199 S ragb susd domaiN-containing protein 0XP53 Cluster_442942 V1200203 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_242519 V1200205 S DNA primase COG3378 Cluster_53510 V1200207 V N-6 DNA Methylase COG0286 Cluster_434859 V1200208 V restriction 11FSE Cluster_153645 V1200210 GLF M udp-galactopyranose mutase COG0562 Cluster_48316 V1200211 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_128178 V1200212 RSGA G May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) COG1162 Cluster_705254 V1200214 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_569925 V1200215 L Transposase 11M0T Cluster_340990 V1200216 C Nitroreductase family COG0778 Cluster_122146 V1200217 S Inherit from COG: ATPase (AAA COG1373 Cluster_189010 V1200218 L TatD-related deoxyribonuclease COG0084 Cluster_352042 V1200219 S NA 0YM1X Cluster_105800 V1200221 S NA 0Z34Z Cluster_89969 V1200222 L Dna topoisomerase COG0550 Cluster_365280 V1200223 SERB map00260,map00680,map01100,map01120,map01230 E phosphoserine phosphatase COG0560 Cluster_112759 V1200226 S NA 11GMQ Cluster_542936 V1200228 S NA COG4694 Cluster_357063 V1200229 S NA COG4694 Cluster_194411 V1200230 S NA COG4694 Cluster_234884 V1200232 map02010 P ABC transporter (Permease) COG0601 Cluster_628980 V1200233 S NA 11EJP Cluster_11634 V1200234 SCLAV_2624 S NA 0YQAJ Cluster_161199 V1200236 MUTT1 L NUDIX hydrolase COG0494 Cluster_30952 V1200237 PPK map00190,map03018 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) COG0855 Cluster_40236 V1200238 SELB map00450,map00970 J Selenocysteine-specific translation elongation factor COG3276 Cluster_737890 V1200239 RLMB J RNA methyltransferase TrmH family group 3 COG0566 Cluster_40859 V1200240 PLC map00562 S Phosphatidylinositol-specific phospholipase C 0ZKFY Cluster_744612 V1200241 XC_0137 L transposase COG3039 Cluster_247734 V1200242 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_800712 V1200243 GLPA map00564,map00730 C fad dependent oxidoreductase COG0579 Cluster_186469 V1200244 CSE4 L Crispr-associated protein, cse4 family 0Y6PV Cluster_336560 V1200245 YAAA L UPF0246 protein COG3022 Cluster_15157 V1200247 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_87256 V1200249 S ATPase (AAA COG1373 Cluster_160369 V1200250 S Phage-Associated Protein COG3600 Cluster_338097 V1200251 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_365281 V1200252 L DNA alkylation repair enzyme COG4912 Cluster_389399 V1200256 SCLAV_3539 G phosphoglycerate mutase COG0406 Cluster_77123 V1200257 S NA 12D1P Cluster_6006 V1200258 S NA 0YG6V Cluster_309269 V1200260 NFRA map00051,map00190,map00363,map00591,map00625,map00633,map00650,map01100,map01120 C nitroreductase COG0778 Cluster_89052 V1200261 L helicase COG4646 Cluster_859275 V1200262 L DNA binding protein, excisionase family 0YKT7 Cluster_812958 V1200264 V restriction endonuclease 0XQN3 Cluster_13290 V1200265 CAS3 L CRISPR-associated helicase, cas3 COG1203 Cluster_309270 V1200266 LPXA map00540,map01100 M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) COG1043 Cluster_61806 V1200268 S Inherit from NOG: LPXTG-motif cell wall anchor domain protein 0YEBJ Cluster_302206 V1200269 COBQ S Glutamine amidotransferase COG3442 Cluster_563638 V1200270 S Uncharacterised protein family (UPF0233) 0ZZV4 Cluster_391124 V1200271 S Conjugative transposon protein TraI 0YE08 Cluster_201873 V1200272 TRAJ S conjugative transposon 0XP5P Cluster_202925 V1200273 T FHA Domain-Containing protein 0ZXYF Cluster_828395 V1200274 S kila-n, DNA-binding domain 0XPNQ Cluster_72477 V1200275 U TraG family COG3505 Cluster_22276 V1200277 RLML L Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) COG1092 Cluster_97349 V1200278 map03440 K Inherit from firmNOG: Transcriptional regulator COG2865 Cluster_473571 V1200279 MDLA V ABC transporter, ATP-binding protein COG1132 Cluster_238597 V1200282 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_48762 V1200283 RECQ2 map03018 L ATP-dependent DNA helicase RecQ COG0514 Cluster_35171 V1200285 map02020,map02030 S Methyl-accepting chemotaxis protein (MCP) signalling domain COG0840 Cluster_239870 V1200286 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate (By similarity) COG0167 Cluster_250300 V1200287 S P-loop domain protein 0XQDB Cluster_271041 V1200288 PANC map00410,map00770,map01100,map01110 H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) COG0414 Cluster_603107 V1200289 S NA 122IS Cluster_305155 V1200290 K AntA/AntB antirepressor COG3645 Cluster_347296 V1200291 S Plasmid pRiA4b ORF-3 family protein 11TVE Cluster_531581 V1200292 S Single-strand binding protein family 0ZH3K Cluster_8818 V1200293 M Inherit from NOG: Polymorphic outer membrane protein 11KKP Cluster_90909 V1200294 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_9027 V1200295 U, W Inherit from COG: domain protein COG5295 Cluster_103993 V1200296 PBUG S Xanthine uracil vitamin C permease COG2252 Cluster_458829 V1200297 RPLJ map03010 J 50s ribosomal protein L10 COG0244 Cluster_417926 V1200298 PNUC H Nicotinamide Mononucleotide Transporter COG3201 Cluster_378812 V1200299 THIN map00730,map01100 H thiamine COG1564 Cluster_239871 V1200300 S kila-n, DNA-binding domain 0XPNQ Cluster_68558 V1200301 L DNA methylase COG2189 Cluster_259033 V1200302 CAS2 L CRISPR-associated protein cas2 11VHR Cluster_59069 V1200304 S NA 11QZ9 Cluster_318410 V1200309 DNAJ3 O DnaJ domain protein COG2214 Cluster_221964 V1200310 S Inherit from NOG: surface antigen 0XQ7Y Cluster_130328 V1200311 RPSA map00900,map01100,map01110,map03010 J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) COG0539 Cluster_21076 V1200313 L dEAD DEAH box helicase COG1204 Cluster_104588 V1200315 GLMU map00520,map01100,map01110 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) COG1207 Cluster_515101 V1200317 map00630,map00680,map01100,map01120 C molybdopterin oxidoreductase Fe4S4 11M2S Cluster_14078 V1200318 S NA 0ZT9Z Cluster_15363 V1200319 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_520335 V1200321 ATPG map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) COG0224 Cluster_12795 V1200324 U, W Pfam:YadA COG5295 Cluster_13493 V1200325 map00511,map00600,map04142 G BNR Asp-box repeat protein COG4409 Cluster_228931 V1200326 I Diacylglycerol kinase COG1597 Cluster_708382 V1200328 GLNR K transcriptional regulator COG0745 Cluster_232414 V1200329 MOBA H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) COG1763 Cluster_202926 V1200330 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_37488 V1200332 GLTS E Sodium Glutamate Symporter COG0786 Cluster_266976 V1200333 MRP D ATP-binding protein COG0489 Cluster_812959 V1200334 K Transcriptional regulator COG1476 Cluster_283100 V1200336 DPRA L DNA protecting protein DprA COG0758 Cluster_440927 V1200337 S Vanz family 0XV9Q Cluster_144210 V1200339 BL01661 map05146 O proteinase inhibitor I4 serpin COG4826 Cluster_66855 V1200340 G Aamy_C COG1523 Cluster_287313 V1200341 M hydrolase, family 25 COG3757 Cluster_18204 V1200342 RES_1 V type IIi COG3421 Cluster_365282 V1200343 LOLD map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_18046 V1200344 CLPC O ATP-dependent Clp protease, ATP-binding subunit ClpC COG0542 Cluster_257705 V1200345 S NA 0Z2K0 Cluster_385846 V1200346 map00730,map01100 H Thiamine monophosphate synthase 11FJG Cluster_50760 V1200347 HSDS V Restriction modification system DNA (Specificity COG0732 Cluster_223144 V1200348 S NA 0YFDR Cluster_300811 V1200350 TATD L Hydrolase, tatD family COG0084 Cluster_196953 V1200351 L type iii restriction protein res subunit COG4951 Cluster_728038 V1200352 S NA 0ZDIF Cluster_124087 V1200353 VEX1 V ABC transporter, permease COG0577 Cluster_425139 V1200355 PTH J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) COG0193 Cluster_84281 V1200356 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_502274 V1200357 S Domain of unknown function (DUF1896) 11Y7P Cluster_769860 V1200359 VSR L DNA mismatch endonuclease (vsr) COG3727 Cluster_43131 V1200363 S domain protein 0YF83 Cluster_871625 V1200364 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_44832 V1200366 RPSA map00900,map01100,map01110,map03010 J Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) COG0761 Cluster_175326 V1200367 S phage protein 0XQDU Cluster_419694 V1200368 S Phage-associated protein 11FS5 Cluster_255200 V1200370 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_179494 V1200373 UGPC map02010 G (ABC) transporter COG3839 Cluster_157803 V1200374 NIFS map00450,map00730,map01100,map04122 E cysteine desulfurase family protein COG0520 Cluster_310710 V1200377 S Inherit from COG: Virulence-associated protein e COG4983 Cluster_475696 V1200379 S C_GCAxxG_C_C family 11W24 Cluster_24360 V1200381 U, W Pfam:YadA COG5295 Cluster_430931 V1200382 HSDM V Type I restriction-modification system, M subunit COG0286 Cluster_180316 V1200383 HSDS V type I restriction modification DNA specificity domain COG0732 Cluster_321375 V1200384 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_61807 V1200386 U, W domain protein COG5295 Cluster_152039 V1200389 S domain protein 0XS27 Cluster_96283 V1200391 SLGD_00086 S Ser Thr phosphatase family protein COG1409 Cluster_27778 V1200392 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_182071 V1200396 UXUA map00040,map01100 G Catalyzes the dehydration of D-mannonate (By similarity) COG1312 Cluster_436909 V1200397 RPLE map03010 J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COG0094 Cluster_211599 V1200406 S NA 122HI Cluster_480322 V1200408 CPHY_1803 L transposase 0XQMH Cluster_789081 V1200410 S NA 0YXS4 Cluster_56495 V1200411 ARGS map00970 J arginyL-tRNA synthetase COG0018 Cluster_31412 V1200412 S NA 0YZ82 Cluster_243865 V1200413 ATPA map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_145707 V1200414 L site-specific recombinase, phage integrase family 0ZF8H Cluster_275047 V1200418 S (LipO)protein 0XSYT Cluster_766075 V1200419 ATPC map00190,map00195,map01100 S Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) 0ZRQB Cluster_80964 V1200420 S (LipO)protein 0XSYT Cluster_329074 V1200421 FECD map02010 P ABC superfamily ATP binding cassette transporter membrane protein COG0609 Cluster_625260 V1200422 TRAF2 S conjugative transposon protein TraF 0YJGM Cluster_714850 V1200423 DEOA map00240,map00983,map01100,map05219 F The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) COG0213 Cluster_377031 V1200424 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_275048 V1200427 STRIC_0432 L Transposase (IS4 family 11HCS Cluster_291275 V1200428 SUFC O feS assembly ATPase SufC COG0396 Cluster_428965 V1200430 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_277687 V1200432 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_285911 V1200434 M hydrolase, family 25 COG3757 Cluster_141256 V1200435 PORAS_0418 L reverse transcriptase COG3344 Cluster_205033 V1200436 K transcriptional regulator 11UUP Cluster_452903 V1200438 map00860,map01100 H Cob-I-yrinic acid a,c-diamide adenosyltransferase COG2109 Cluster_484955 V1200439 SP_0119 L Nudix family COG0494 Cluster_245136 V1200441 YDJZ S SNARE associated Golgi protein-related protein COG0398 Cluster_871626 V1200442 PRFC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) COG4108 Cluster_528795 V1200445 S Protein of unknown function (DUF3408) 11QAR Cluster_210466 V1200446 S NA 0XTEF Cluster_336561 V1200450 TRPF map00400,map01100,map01110,map01230 E N-(5'-phosphoribosyl)anthranilate isomerase COG0135 Cluster_423356 V1200451 CASB S CRISPR system CASCADE complex protein CasB 0ZXJT Cluster_338098 V1200452 map03070 S NA 122A7 Cluster_224320 V1200454 S Pfam:YadA 0YNSE Cluster_326016 V1200455 AMPG2 E, G, P Beta-lactamase induction signal transducer COG0477 Cluster_277688 V1200456 UDK map00240,map00983,map01100 F uridine kinase COG0572 Cluster_49965 V1200460 U, W Domain-Containing protein COG5295 Cluster_515102 V1200461 S NA 0ZQAM Cluster_96802 V1200463 S NA 0Y9G8 Cluster_531582 V1200468 HSP20 map04141 O Heat shock protein COG0071 Cluster_835986 V1200470 BL00603 S Protein of unknown function (DUF2089) 125WH Cluster_442943 V1200471 LUXS map00270,map05111 T Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) COG1854 Cluster_724786 V1200473 V ABC transporter, permease protein 0XP9H Cluster_50357 V1200475 U, W surface protein COG5295 Cluster_56763 V1200477 NIFJ map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map00910,map01100,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_122824 V1200478 V restriction endonuclease 0Z1AJ Cluster_385847 V1200480 S NA 0XQ5H Cluster_621470 V1200484 WZB T protein tyrosine phosphatase COG0394 Cluster_116988 V1200487 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_454927 V1200492 K RNA Polymerase COG1595 Cluster_792875 V1200493 S toxin-antitoxin system, antitoxin component, Xre family 0Y0YN Cluster_192588 V1200496 S ApbE family 11H27 Cluster_114873 V1200497 XC_0137 L transposase COG3039 Cluster_276382 V1200502 S NA 12BYI Cluster_71512 V1200503 M Glycosyl hydrolases family 25 COG5263 Cluster_399978 V1200505 S NA 0ZHU9 Cluster_62624 V1200507 map02010 P ABC transporter COG1131 Cluster_357064 V1200508 S membrAne 120XT Cluster_674043 V1200509 LICB map02060 G PTS System COG1440 Cluster_94161 V1200511 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_174510 V1200512 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_202927 V1200513 MBL D Rod shape-determining protein mreb COG1077 Cluster_154446 V1200514 PSEH map00330,map00350,map00362,map00520,map00627,map00642,map00903,map01100,map01120 J -acetyltransferase COG1670 Cluster_724787 V1200518 S Abortive infection protein AbiGII 0XQHH Cluster_636812 V1200519 S NA 0YVCN Cluster_137467 V1200520 S conjugative transposon 0YI63 Cluster_636813 V1200521 RLUD J Pseudouridine synthase COG0564 Cluster_434860 V1200523 S NA 125RT Cluster_436910 V1200524 PNCA map00760,map01100 Q isochorismatase COG1335 Cluster_260333 V1200525 L Site-specific recombinase COG1961 Cluster_288671 V1200528 PYRF map00240,map00983,map01100 F orotidine 5''-phosphate decarboxylase COG0284 Cluster_576353 V1200529 S NA 11HB4 Cluster_157804 V1200532 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_75466 V1200536 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_124740 V1200538 YEEA V methylase COG1002 Cluster_303654 V1200539 O ADP-ribosylglycohydrolase COG1397 Cluster_835989 V1200540 S NA 127RR Cluster_79152 V1200542 U, W Inherit from COG: domain protein COG5295 Cluster_316845 V1200543 V type I restriction modification DNA specificity domain COG0732 Cluster_294017 V1200544 HSDM V Type I restriction-modification system, M subunit COG0286 Cluster_202928 V1200545 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_454928 V1200551 S NA 101EI Cluster_900338 V1200552 G pfkb domain protein COG0524 Cluster_847826 V1200553 XERD L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_148815 V1200554 DXR map00900,map01100,map01110 I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) COG0743 Cluster_592553 V1200555 CCEL_3034 S NA 0XYGI Cluster_773498 V1200556 LYSM S Lysm domain protein 12BED Cluster_446963 V1200558 OADA map00020,map00330,map00620,map00720,map01100,map01120,map01230 C Oxaloacetate decarboxylase COG5016 Cluster_89053 V1200560 U, W Inherit from COG: domain protein 121KM Cluster_316846 V1200561 M Cell wall anchor domain protein 11Q8J Cluster_144961 V1200563 map00230,map01100,map01110 F AICARFT/IMPCHase bienzyme COG0138 Cluster_832066 V1200564 S Recombinase 0Y2JQ Cluster_592554 V1200565 L Site-specific recombinase COG1961 Cluster_494567 V1200566 TEX K domain protein COG2183 Cluster_94162 V1200571 S transglutaminase domain-containing protein 0XQP2 Cluster_199877 V1200572 S NA 0ZUV9 Cluster_640838 V1200575 S NA 127RR Cluster_683052 V1200576 S Addiction module antitoxin, RelB DinJ family 0XUTM Cluster_557624 V1200577 K Transcriptional regulator, TetR family 128VI Cluster_166138 V1200581 map02010 P Periplasmic binding protein COG0614 Cluster_446964 V1200582 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_168519 V1200583 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) COG0167 Cluster_566835 V1200587 UDP map00230 S phosphorylase 11F11 Cluster_116989 V1200588 U, W surface protein COG5295 Cluster_566836 V1200589 RPSH map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) COG0096 Cluster_157805 V1200592 S NA 0ZYTH Cluster_121383 V1200593 map02010 G solute-binding protein COG1653 Cluster_279050 V1200595 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_534356 V1200597 S NA 11SH1 Cluster_551854 V1200599 PURM map00230,map01100,map01110 F phosphoribosylaminoimidazole synthetase COG0150 Cluster_116279 V1200600 S NA 0XSI9 Cluster_237279 V1200603 M glycosyltransferase group 2 family protein COG0463 Cluster_305156 V1200605 TNP7109-5 L transposase COG2801 Cluster_178614 V1200606 M ompA MotB domain-containing protein COG2885 Cluster_360400 V1200609 LYSA map00300,map01100,map01110,map01120,map01230 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) COG0019 Cluster_122147 V1200610 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_299451 V1200613 V ABC transporter, permease protein 0XP9H Cluster_125402 V1200614 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_380531 V1200615 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_366986 V1200618 S Endonuclease Exonuclease phosphatase 0XPGG Cluster_718115 V1200619 S Protein of unknown function (DUF3298) 0Y1DT Cluster_721427 V1200620 PURA map00230,map00250,map01100 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis COG0104 Cluster_133474 V1200622 U, W Pfam:YadA COG5295 Cluster_245137 V1200623 S periplasmic component of amino acid ABC-type transporter signal transduction system 11IU5 Cluster_867722 V1200624 CRCB D Protein CrcB homolog COG0239 Cluster_348924 V1200627 S Domain of unknown function DUF20 COG0628 Cluster_260334 V1200628 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_139773 V1200630 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_214992 V1200631 TOPB map03018 L DNA topoisomerase COG0550 Cluster_268378 V1200633 PSTS map02010,map02020,map05152 P phosphate COG0226 Cluster_143462 V1200634 L helicase COG4646 Cluster_327575 V1200635 MEND map00130,map01100,map01110 H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) COG1165 Cluster_576354 V1200638 map02020,map02030 T Response regulator receiver domain COG0784 Cluster_236081 V1200639 PEPR map00330 E Releases the N-terminal proline from various substrates (By similarity) 0ZVHU Cluster_465086 V1200640 YIGL S Hydrolase COG0561 Cluster_625261 V1200643 TRAF2 S conjugative transposon protein TraF 0YJGM Cluster_196954 V1200644 PURB map00230,map00250,map01100,map01110 F Adenylosuccinate lyase COG0015 Cluster_196139 V1200646 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_153646 V1200647 ARCA map00330,map01100,map01110 E Arginine dihydrolase COG2235 Cluster_847827 V1200648 S NA 11VCX Cluster_231248 V1200649 S NA 11VIT Cluster_257706 V1200651 S NA 100FP Cluster_705257 V1200652 S NA 0ZHU9 Cluster_223145 V1200654 S NA 0YQTT Cluster_408799 V1200656 NTH map03410 L endonuclease III COG0177 Cluster_405355 V1200659 HSDR V Type I Restriction COG0610 Cluster_170312 V1200660 M Catalyzes the conversion of a range of fructosamine 6- phosphates to glucose 6-phosphate and a free amino acid (By similarity) COG2222 Cluster_172869 V1200661 U, W Domain-Containing protein COG5295 Cluster_363543 V1200666 GSIA map02010 S (ABC) transporter COG1123 Cluster_360401 V1200671 REX K Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) COG2344 Cluster_401764 V1200672 DEOD map00230,map00240,map00270,map00760,map01100,map01110 F purine nucleoside phosphorylase DeoD-type COG0813 Cluster_674045 V1200674 S NA 0YBIC Cluster_208343 V1200678 MENC map00130,map01100,map01110 M mandelate racemase muconate lactonizing COG4948 Cluster_396536 V1200679 LEXA K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) COG1974 Cluster_188167 V1200682 S SusD family 0XPTK Cluster_202929 V1200686 HOLA map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii, delta' subunit COG1466 Cluster_189011 V1200687 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_692024 V1200689 NANM S Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) COG3055 Cluster_193473 V1200692 S NA 12D73 Cluster_196140 V1200695 M Membrane COG4775 Cluster_196141 V1200696 NANH map00511,map00600,map04142 G BNR Asp-box repeat protein COG4409 Cluster_695821 V1200697 S NA 0ZHU9 Cluster_596021 V1200699 E peptidase, M24 COG0006 Cluster_702196 V1200703 T PP2Cc 0YSXA Cluster_277689 V1200706 E, P Permease protein COG1173 Cluster_296765 V1200707 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_665361 V1200708 S NA 0ZHU9 Cluster_674046 V1200711 DCM map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_360402 V1200712 HFLC O SPFH domain, Band 7 family protein COG0330 Cluster_241149 V1200716 S NA 11NI8 Cluster_284466 V1200717 MANA map00051,map00520,map01100,map01110 G mannose-6-phosphate isomerase COG1482 Cluster_219611 V1200719 FIXA V ABC transporter, ATP-binding protein COG1131 Cluster_226619 V1200722 S Lipase (class 3) 0ZJUJ Cluster_432946 V1200725 E peptidase 0XRNU Cluster_734591 V1200726 J Glutamine amidotransferase COG2355 Cluster_419695 V1200732 S NA 11RX2 Cluster_859278 V1200738 S Membrane 11VWS Cluster_243866 V1200739 HCAN_0220 S Pfam:DUF395 0XPA5 Cluster_256422 V1200741 S NA 123I1 Cluster_302207 V1200743 P ABC transporter (Permease COG0600 Cluster_648769 V1200744 TFOX K TfoX, N-terminal domain protein COG3070 Cluster_744614 V1200745 S NA 0ZHU9 Cluster_687441 V1200746 S NA 17D58@proNOG Cluster_777238 V1200748 PILT N, U twitching motility protein COG2805 Cluster_391125 V1200751 CLOSA_1745 L transposase COG2963 Cluster_335025 V1200758 M hydrolase, family 25 COG3757 Cluster_566837 V1200763 HSLO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) COG1281 Cluster_268379 V1200764 RECQ map03018 L ATP-dependent DNA helicase RecQ COG0514 Cluster_484956 V1200767 FOLK map00790,map01100 H 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase COG0801 Cluster_648770 V1200769 ALAT map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aspartate transaminase COG0436 Cluster_360403 V1200771 K TRANSCRIPTIONal COG3711 Cluster_734592 V1200772 S NA 11KIH Cluster_277690 V1200775 S NA 0Y00S Cluster_423357 V1200776 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_275049 V1200777 ATPA map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_294018 V1200778 HK01 T Histidine kinase COG0642 Cluster_280354 V1200780 I Acyl-ACP thioesterase COG3884 Cluster_384088 V1200782 CYSK map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_284467 V1200784 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_548953 V1200787 O Inherit from COG: glutaredoxin-related protein COG4545 Cluster_603109 V1200789 S NA 0ZUV1 Cluster_460882 V1200791 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_298168 V1200798 U, W Pfam:YadA COG5295 Cluster_412478 V1200799 MDMC map00340,map00350,map00360,map00624,map00940,map00941,map00945,map01100,map01110,map01120 S O-methyltransferase COG4122 Cluster_463001 V1200800 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_758393 V1200802 S NA 0ZJP4 Cluster_494568 V1200803 OCAR_6158 L Terminase, large subunit COG4626 Cluster_721428 V1200804 map00520,map01110 G hydrolase family COG1472 Cluster_338099 V1200805 FRUA map00051,map01100,map02060 G PTS System COG1762 Cluster_467172 V1200806 L site-specific recombinase, phage integrase family 0ZF8H Cluster_859279 V1200807 YCBB S ErfK YbiS YcfS YnhG family protein COG2989 Cluster_851581 V1200808 V Type III restriction enzyme, res subunit 0ZVHQ Cluster_699104 V1200809 S VRR-NUC domain protein 122HE Cluster_318411 V1200812 S Inherit from COG: ATPase (AAA COG1373 Cluster_839797 V1200817 K Cupin domain COG1396 Cluster_347297 V1200818 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_360404 V1200824 ADK map00230,map00240,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_327576 V1200826 TRMI J tRNA (Adenine-N1-)-methyltransferase COG2519 Cluster_405356 V1200828 HMUY S NA 0XZUM Cluster_912988 V1200830 S NA 0ZHU9 Cluster_741344 V1200833 S NA 0ZHU9 Cluster_333523 V1200834 P TonB-dependent receptor 1AIHM@sphNOG Cluster_523096 V1200835 YCBB S ErfK YbiS YcfS YnhG family protein COG2989 Cluster_458831 V1200836 LEUD map00290,map00300,map00660,map01100,map01110,map01210,map01230 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) COG0066 Cluster_494569 V1200838 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_336562 V1200839 ACRA6 V efflux transporter, rnd family, mfp subunit COG0845 Cluster_408800 V1200840 HEMN map00860,map01100,map01110 C coproporphyrinogen COG0635 Cluster_579443 V1200845 RPLS map03010 J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) COG0335 Cluster_347298 V1200848 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_614020 V1200850 INSI L transposase COG2826 Cluster_702198 V1200852 S NA 0ZHU9 Cluster_352043 V1200856 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_352044 V1200857 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_507236 V1200858 NAGC map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 K ROK family COG1940 Cluster_353711 V1200859 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_573131 V1200861 AMD E amidohydrolase COG1473 Cluster_484957 V1200862 UBIE map00130,map01100,map01110 H Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) COG2226 Cluster_357065 V1200863 S Membrane 0XRRH Cluster_357066 V1200864 S relaxase mobilization nuclease domain protein 0XNXG Cluster_839799 V1200868 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_674047 V1200871 P TonB-dependent receptor Plug 0XNPQ Cluster_628982 V1200874 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_366987 V1200879 HEMZ map00860,map01100,map01110 C coproporphyrinogen COG0635 Cluster_366988 V1200880 OPPD E, P ABC transporter COG0444 Cluster_384089 V1200881 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_368607 V1200882 L Integrase COG0582 Cluster_656959 V1200883 S phospholipid-binding protein COG1881 Cluster_430932 V1200886 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0847 Cluster_557625 V1200887 CDD map00240,map00983,map01100,map05219 F cytidine deaminase COG0295 Cluster_370319 V1200888 S Abortive infection protein AbiGI 11WH3 Cluster_440928 V1200891 L phage plasmid primase, p4 family COG3378 Cluster_373550 V1200892 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E amino acid aminotransferase COG0115 Cluster_859280 V1200901 S HTH domain protein 11Z0Z Cluster_891934 V1200903 S NA 0ZHU9 Cluster_382300 V1200906 M NLP P60 protein COG2247 Cluster_380532 V1200908 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_452904 V1200911 I diacylglycerol kinase, catalytic COG1597 Cluster_387692 V1200914 INFC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) COG0290 Cluster_754850 V1200916 RESD map02020 T Response regulator receiver domain protein COG0745 Cluster_389400 V1200918 AROB map00400,map01100,map01110,map01230 E 3-dehydroquinate synthase COG0703 Cluster_391126 V1200924 S NA 0Y83C Cluster_579444 V1200925 TYPA T gtp-binding protein typa COG1217 Cluster_427076 V1200926 U Biopolymer transport protein exbD tolR 11JQD Cluster_398261 V1200929 CLPP map04112 O ATP-dependent Clp protease, proteolytic subunit COG0740 Cluster_438960 V1200931 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_820511 V1200932 S NA 0ZHU9 Cluster_515103 V1200936 RBSA S ABC transporter COG3845 Cluster_531584 V1200938 L transposase COG3666 Cluster_401766 V1200942 map00051 M group 2 family COG0463 Cluster_489588 V1200944 K transcriptional regulator AsnC family COG1522 Cluster_471454 V1200948 CELAL_0017 S NA 11TT6 Cluster_407046 V1200953 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_408801 V1200954 FBA map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01230 G fructose-bisphosphate aldolase COG0191 Cluster_410659 V1200956 map00500,map01100 N Alpha-L-fucosidase 0XPGV Cluster_410660 V1200958 S phosphate 0XP49 Cluster_678506 V1200960 RPSJ map03010 J Involved in the binding of tRNA to the ribosomes (By similarity) COG0051 Cluster_412481 V1200961 T response regulator (Receiver 11EZS Cluster_414337 V1200963 S NA 0YCCW Cluster_414338 V1200964 map00330,map01110,map01230 E Ornithine Cyclodeaminase COG2423 Cluster_450956 V1200966 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_741346 V1200968 PGSA2 map00564,map01100 I Cdp-alcohol phosphatidyltransferase COG0558 Cluster_557626 V1200970 APT map00230,map01100 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) COG0503 Cluster_417927 V1200971 S NA 11HVF Cluster_419697 V1200975 S domain protein 0XNZW Cluster_751418 V1200977 COXC map00190,map00910,map01100 C Cytochrome C Oxidase, Subunit III COG1845 Cluster_421495 V1200981 GLNN map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG3968 Cluster_773502 V1200984 P TonB-dependent receptor Plug COG4771 Cluster_425140 V1200986 DPNA L helicase COG4646 Cluster_499728 V1200992 S Phage terminase small subunit 11F23 Cluster_828402 V1200996 L site-specific recombinase, phage integrase family 0ZF8H Cluster_610388 V1200997 L Integrase 0YTFQ Cluster_432947 V1201003 HSDR V Type I Restriction COG0610 Cluster_434863 V1201007 BMUL_0955 map00030,map01100,map01110,map01120 G 6-phosphogluconolactonase (EC 3.1.1.31) COG2706 Cluster_467173 V1201009 U, W Pfam:Hep_Hag COG5295 Cluster_452905 V1201010 S Adenylate cyclase COG2954 Cluster_804963 V1201011 NTH map03410 L endonuclease III COG0177 Cluster_548954 V1201013 S Acyltransferase family 0YAKZ Cluster_452906 V1201029 U, W Pfam:YadA COG5295 Cluster_452907 V1201033 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_891936 V1201039 RNHA map03030 S Ribonuclease COG3341 Cluster_454930 V1201044 M Cell wall anchor domain protein 11Q8J Cluster_456868 V1201046 MRAZ S Cell division protein mraZ COG2001 Cluster_509834 V1201048 U TraG family COG3505 Cluster_458832 V1201050 S NA 11NI8 Cluster_477902 V1201051 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_528797 V1201058 S Uncharacterised protein family (UPF0233) 0ZZV4 Cluster_582681 V1201060 MTAD F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) COG0402 Cluster_465088 V1201063 MURF map00300,map00550,map01100 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) COG0770 Cluster_465089 V1201067 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_465090 V1201068 S NA 0XTWQ Cluster_563641 V1201074 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_469321 V1201076 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_471455 V1201077 PRIA map03440 L Primosomal protein n' COG1198 Cluster_520337 V1201084 GATB map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 Cluster_537273 V1201088 YHCG V abc transporter atp-binding protein COG1131 Cluster_473572 V1201089 map02010 P ABC transporter COG1121 Cluster_542938 V1201091 GLTT C Proton sodium-glutamate symport protein GltT COG1301 Cluster_528798 V1201093 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_475697 V1201095 I Diacylglycerol kinase COG1597 Cluster_475698 V1201096 C FMN-binding domain protein COG3976 Cluster_582682 V1201103 map00010 G Glycosyl hydrolase family 1 COG2723 Cluster_724791 V1201111 G polysaccharide deacetylase COG0726 Cluster_484958 V1201113 E amino acid COG0531 Cluster_758394 V1201115 L DNA topoisomerase COG0550 Cluster_489590 V1201118 MRAY map00550,map01100 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) COG0472 Cluster_596022 V1201119 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_494570 V1201121 P tonB-dependent receptor plug 0YT3X Cluster_494571 V1201124 RMUC S Dna recombination protein COG1322 Cluster_497078 V1201130 L RecA-family ATPase COG3598 Cluster_534358 V1201133 YPDE map00500,map01100 E Peptidase m42 family protein COG1363 Cluster_499729 V1201134 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_504666 V1201141 S Alpha beta hydrolase COG0596 Cluster_504667 V1201143 PPNK map00760,map01100 G Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) COG0061 Cluster_507237 V1201145 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_606724 V1201146 FLHB2 S flagellar COG2257 Cluster_617807 V1201147 L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) COG0582 Cluster_512411 V1201152 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_512412 V1201153 ISDF map02010 P ABC transporter, permease COG0609 Cluster_515104 V1201157 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_515105 V1201158 ACD map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I Acyl-coa dehydrogenase COG1960 Cluster_515106 V1201159 QUEE map00790,map01100 H Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) COG0602 Cluster_515107 V1201160 D Conjugative transposon protein TraA 0Y9K3 Cluster_517797 V1201163 ELI_1297 O phage portal protein HK97 family COG4695 Cluster_545892 V1201164 PHUW E Iron-regulated protein COG3016 Cluster_517798 V1201166 S NA 0ZTYV Cluster_520338 V1201168 P tonB-dependent Receptor 0XQ03 Cluster_523097 V1201172 map02010 S transporter, permease COG4587 Cluster_523098 V1201178 V HpaII restriction endonuclease 11A91 Cluster_747985 V1201183 S Transglycosylase associated protein 12314 Cluster_526030 V1201185 S Endonuclease Exonuclease phosphatase 0ZJ9Y Cluster_851588 V1201187 map00052,map00500,map01100 G F5 8 type C domain protein COG1501 Cluster_531585 V1201197 S Pfam:YadA 0ZHSU Cluster_718119 V1201198 SECG map03060,map03070 U Preprotein translocase SecG subunit 121MY Cluster_542939 V1201217 L DNA polymerase 0XRUF Cluster_542940 V1201219 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_875764 V1201220 RLMH S Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) COG1576 Cluster_545893 V1201221 V ATPase associated with various cellular activities aaa_5 COG1401 Cluster_762100 V1201222 S NA 0ZHU9 Cluster_545894 V1201224 S helicase COG3972 Cluster_592555 V1201226 CYSN map00230,map00450,map00920,map01100,map01120 P May be the GTPase, regulating ATP sulfurylase activity (By similarity) COG2895 Cluster_548955 V1201227 MT2607 map00330,map00480,map01100,map01110 E decarboxylase COG1982 Cluster_912991 V1201230 G ROK family COG1940 Cluster_582683 V1201233 S Single-stranded nucleic acid binding R3H domain-containing protein COG1847 Cluster_665363 V1201238 SPOVG M Could be involved in septation (By similarity) COG2088 Cluster_554709 V1201243 map00051,map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 G Glycosyl hydrolase family 20 COG3525 Cluster_812966 V1201244 S NA 0ZHU9 Cluster_589189 V1201253 MURE map00300,map00550,map01100 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_560699 V1201254 S NA 0YG6V Cluster_711468 V1201258 O AAA domain (Cdc48 subfamily) COG0464 Cluster_563643 V1201259 S Relaxase mobilization nuclease 0Y9PG Cluster_563644 V1201260 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_563645 V1201261 HSPR K merR family transcriptional Regulator COG0789 Cluster_585883 V1201263 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_566838 V1201264 S fad dependent oxidoreductase COG2509 Cluster_569927 V1201270 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_573132 V1201275 V Type I Restriction COG0732 Cluster_632777 V1201280 FUCP G glucose galactose transporter COG0738 Cluster_576355 V1201282 S YitT family COG1284 Cluster_576356 V1201288 S radical SAM domain protein COG0641 Cluster_579446 V1201289 AQPZ G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) COG0580 Cluster_579448 V1201292 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (alpha subunit) COG0587 Cluster_579450 V1201295 MAP2 map00500,map01100 G hydrolase family 65, central catalytic COG1554 Cluster_585886 V1201308 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_855388 V1201310 YQFL S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) COG1806 Cluster_699108 V1201312 map00010 G Glycosyl hydrolase, family 1 COG2723 Cluster_592556 V1201313 M Nucleotidyl transferase COG1208 Cluster_596023 V1201319 SIGH map02020 K RNA polymerase COG1595 Cluster_596024 V1201322 LGAS_0607 T head morphogenesis protein, SPP1 gp7 COG5585 Cluster_832072 V1201323 S NA 0Y3Q9 Cluster_599547 V1201336 HTPG map04141,map04151,map04612,map04621,map04626,map04914,map04915,map05200,map05215 O Molecular chaperone. Has ATPase activity (By similarity) COG0326 Cluster_708383 V1201337 map00230,map01100,map01110 F AICARFT/IMPCHase bienzyme COG0138 Cluster_599548 V1201338 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin 0XQTW Cluster_702199 V1201345 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit alpha COG0587 Cluster_606725 V1201347 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG0469 Cluster_606726 V1201349 HISC map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01230 E Imidazole acetol-phosphate transaminase COG0079 Cluster_610389 V1201353 U, W Pfam:YadA COG5295 Cluster_614022 V1201354 map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase COG3958 Cluster_614023 V1201355 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_610390 V1201357 RPSA map00900,map01100,map01110,map03010 J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) COG0539 Cluster_614024 V1201358 S Thiol disulfide interchange protein DsbD 1AKF0@sphNOG Cluster_617809 V1201364 FUCA map00511 G Alpha-L-fucosidase COG3669 Cluster_617810 V1201365 SCLAV_4722 J Methyltransferase COG2813 Cluster_621474 V1201370 DUSB J Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_640841 V1201378 YACP J Tetracycline resistance protein COG3688 Cluster_887877 V1201381 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_912993 V1201383 RPIA map00030,map00710,map01100,map01110,map01120,map01230 G phosphoriboisomerase A COG0120 Cluster_640842 V1201395 S (LipO)protein 0YDWI Cluster_731343 V1201403 S NA 0ZHU9 Cluster_644716 V1201408 DAPE1 map00300,map00310,map00330,map00780,map01100,map01110,map01120,map01210,map01230 E peptidase COG0624 Cluster_644717 V1201412 L Inherit from COG: transposase COG3666 Cluster_648773 V1201414 PRFC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) COG4108 Cluster_705260 V1201423 S PAP2 superfamily domain protein 11HHM Cluster_656962 V1201425 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_656963 V1201427 T Histidine kinase COG0642 Cluster_674050 V1201434 S NA 101UU Cluster_678509 V1201436 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) COG0442 Cluster_674051 V1201438 S NA 11NI8 Cluster_678510 V1201439 L Virulence-associated protein e COG5545 Cluster_674052 V1201440 DPNA L helicase COG4646 Cluster_678511 V1201442 K, L domain protein COG0553 Cluster_678512 V1201446 F formate-tetrahydrofolate ligase COG2759 Cluster_785103 V1201450 D, T, Z signal transduction protein with EFhand domain COG5126 Cluster_687446 V1201456 O Inherit from COG: ubiquitin COG5272 Cluster_692027 V1201460 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_105801 V1201469 GLNA map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG0174 Cluster_29302 V1201472 RECG map03440 L ATP-dependent DNA helicase RecG COG1200 Cluster_236082 V1201473 TRPA map00260,map00400,map01100,map01110,map01230 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) COG0159 Cluster_48317 V1201474 S Inherit from NOG: Histidine triad protein 11G35 Cluster_509835 V1201476 BCP O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG1225 Cluster_392937 V1201477 S NA 0YH5F Cluster_13172 V1201478 O cysteine protease COG4870 Cluster_52824 V1201479 HSDS V Restriction modification system DNA (Specificity COG0732 Cluster_796859 V1201480 S Pfam:PhdYeFM 0XWRR Cluster_72151 V1201481 CBIO map02010 P ABC transporter COG1122 Cluster_12074 V1201482 S NA 11YT1 Cluster_632778 V1201483 S mobilization protein 11J0G Cluster_843912 V1201485 S NA 122EK Cluster_3947 V1201486 S Pfam:YadA 126HB Cluster_13625 V1201487 ACTP P p-type ATPase COG2217 Cluster_196142 V1201489 S cell wall binding COG5263 Cluster_33522 V1201490 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_14348 V1201491 PPC map00620,map00680,map00710,map00720,map01100,map01120 C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) COG2352 Cluster_610391 V1201492 SGAB map00053,map01100,map01120,map02060 G PTS System 126BH Cluster_43704 V1201493 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_42596 V1201494 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 Cluster_134259 V1201495 HSDS V restriction modification system DNA specificity domain COG0732 Cluster_6165 V1201497 ADDA L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation COG1074 Cluster_7298 V1201498 K TRANSCRIPTIONal 11ZCE Cluster_2203 V1201499 S NA 0YG6V Cluster_198877 V1201500 APBA map00770,map01100,map01110 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) COG1893 Cluster_30351 V1201501 S Putative cell wall binding repeat 0YEGX Cluster_195290 V1201502 PRMA J Methylates ribosomal protein L11 (By similarity) COG2264 Cluster_377032 V1201503 S NA 11RJG Cluster_102791 V1201504 MURE map00300,map00550 M mur ligase COG0769 Cluster_432948 V1201505 MAF D MAF-like protein COG0424 Cluster_133475 V1201506 FLIC map02020,map02040,map04626,map05132,map05134 N Flagellin COG1344 Cluster_23283 V1201507 ACTP1 P Copper-exporting ATPase COG2217 Cluster_118395 V1201508 V Mate efflux family protein COG0534 Cluster_324511 V1201509 S Membrane COG1811 Cluster_644718 V1201510 RPLU map03010 J This protein binds to 23S rRNA in the presence of protein L20 (By similarity) COG0261 Cluster_50156 V1201511 S NA 0YIAW Cluster_9984 V1201512 U, W domain protein COG5295 Cluster_180317 V1201513 S domain protein 0YF83 Cluster_30477 V1201514 F ATP cone domain COG1328 Cluster_576357 V1201517 CCEL_3034 S NA 0XYGI Cluster_3625 V1201518 M Inherit from COG: peptidase' 0XPHJ Cluster_74180 V1201522 BL00983 S Phage Portal Protein 11QNG Cluster_13125 V1201523 AMET_0415 S phage protein 0Y97T Cluster_93743 V1201528 BL03493 L phage plasmid primase, p4 family COG4983 Cluster_192590 V1201529 S YqaJ-like viral recombinase domain 125D5 Cluster_18955 V1201530 L DNA polymerase 0Y9P0 Cluster_118396 V1201531 L snf2 family COG0553 Cluster_85112 V1201532 L Resolvase COG1961 Cluster_10190 V1201534 S Relaxase Mobilization nuclease domain protein 0XRAY Cluster_57513 V1201535 U Type IV secretory pathway VirD4 COG3505 Cluster_272369 V1201536 S NA 11Z1K Cluster_228933 V1201537 S NA 126B8 Cluster_917390 V1201538 S NA 0Y6R4 Cluster_20999 V1201540 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG1214 Cluster_315317 V1201541 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_29071 V1201542 CIRA P Receptor COG4771 Cluster_272370 V1201543 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_256423 V1201544 TERC P Membrane protein terC COG0861 Cluster_54750 V1201545 YFMR S abc transporter COG0488 Cluster_171962 V1201546 V restriction endonuclease 0Z1AJ Cluster_146505 V1201547 V ATPase associated with various cellular activities aaa_5 COG1401 Cluster_347299 V1201549 V DNA methylase COG0863 Cluster_188168 V1201550 DCM map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_820519 V1201551 L DNA binding domain protein, excisionase family 121NU Cluster_585888 V1201552 L DNA methylase COG2189 Cluster_104589 V1201553 RMUC S Dna recombination protein COG1322 Cluster_273700 V1201554 TRPF map00400,map01100,map01110,map01230 E N-(5'-phosphoribosyl)anthranilate isomerase COG0135 Cluster_432949 V1201555 EFP J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) COG0231 Cluster_5343 V1201556 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_262952 V1201557 CHEX-4 S NA 11NTE Cluster_25496 V1201558 PRIA map03440 L Primosomal protein n' COG1198 Cluster_79475 V1201559 HSDM V type I restriction-modification system COG0286 Cluster_365283 V1201560 M Transglycosylase SLT domain 0ZC8U Cluster_507238 V1201561 S toxin-antitoxin system, antitoxin component, Xre family 0ZIHY Cluster_196143 V1201562 L site-specific recombinase, phage integrase family 11IW4 Cluster_462 V1201563 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_51322 V1201564 map00020,map00190,map00250,map00623,map00650,map00720,map00760,map01100,map01110,map01120,map05134 C Fumarate reductase succinate dehydrogenase flavoprotein domain-containing protein COG1053 Cluster_273 V1201565 FAS map00061,map01100 I fatty acid synthase COG4982 Cluster_249037 V1201566 M hydrolase, family 25 COG3757 Cluster_65994 V1201567 L Site-specific recombinase COG1961 Cluster_59344 V1201568 S Inherit from NOG: domain protein 0XXVB Cluster_30231 V1201569 V Type III restriction enzyme, res subunit 0ZVEA Cluster_51918 V1201570 OCAR_4032 S Domain of unknown function DUF87 COG0433 Cluster_303655 V1201571 S NA 11IAR Cluster_239872 V1201572 S Inherit from NOG: Relaxase/Mobilisation nuclease domain 0XT8X Cluster_195291 V1201573 HPAIIM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_515108 V1201574 VSR L DNA mismatch endonuclease Vsr COG3727 Cluster_44485 V1201575 S NA 129DJ Cluster_63743 V1201580 HEMA map00860,map01100,map01110 H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) COG0373 Cluster_289968 V1201582 S NA 0ZNPR Cluster_88567 V1201584 BL00983 S Phage Portal Protein 11QNG Cluster_780933 V1201587 S NA 1228P Cluster_89970 V1201590 S phage plasmid primase, p4 family COG3378 Cluster_310711 V1201591 S Inherit from COG: Virulence-associated protein e COG4983 Cluster_197887 V1201595 S YqaJ-like viral recombinase domain 125D5 Cluster_21765 V1201596 L DNA polymerase 0Y9P0 Cluster_79782 V1201598 map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_108175 V1201599 L Inherit from COG: type iii restriction protein res subunit COG1061 Cluster_414339 V1201601 S NA 11M9C Cluster_85113 V1201602 S G5 COG3583 Cluster_188169 V1201603 ORFL L transposase COG2826 Cluster_156092 V1201604 HSDS V restriction COG0732 Cluster_162878 V1201605 S NA 1784J@proNOG Cluster_94163 V1201606 U, W Domain-Containing protein COG5295 Cluster_382302 V1201607 RSMG M Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) COG0357 Cluster_8292 V1201609 U, W Pfam:YadA COG5295 Cluster_3438 V1201610 U, W Inherit from COG: domain protein COG5295 Cluster_69934 V1201611 MPHA S Aminoglycoside phosphotransferase 0YEJ0 Cluster_128888 V1201612 XYLR G, K ROK family COG1940 Cluster_12525 V1201613 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_11026 V1201614 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_17369 V1201615 HYPF O hydrogenase maturation protein Hypf COG0068 Cluster_268381 V1201616 S NA 12BZ7 Cluster_28964 V1201618 PFLB map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_264336 V1201622 S NA 12B6B Cluster_17066 V1201623 SCLAV_1560 map02010 P ABC transporter COG1122 Cluster_67516 V1201625 AHPF O Alkyl hydroperoxide reductase COG3634 Cluster_353712 V1201627 S NA 0Y67R Cluster_2688 V1201628 MT3296 L helicase COG0210 Cluster_25308 V1201629 PEPN map00480,map01100 E aminopeptidase N COG0308 Cluster_777243 V1201632 S NA 0Z0D1 Cluster_36396 V1201633 S peptidase 0XPBV Cluster_20545 V1201634 S Inherit from COG: leucine Rich Repeat COG4886 Cluster_414340 V1201636 CVRA P Participates in control of cell volume in low-osmolarity conditions (By similarity) COG3263 Cluster_6037 V1201637 NIFJ map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map00910,map01100,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_94164 V1201638 U, W Domain-Containing protein COG5295 Cluster_6007 V1201639 U, W Pfam:YadA COG5295 Cluster_98430 V1201640 map03440 K Inherit from bactNOG: transcriptional regulator COG2865 Cluster_711472 V1201641 V Abi-like protein COG4823 Cluster_773505 V1201642 L Inherit from COG: transposase COG2826 Cluster_70537 V1201643 U, W Domain-Containing protein COG5295 Cluster_63459 V1201644 U, W surface protein COG5295 Cluster_170313 V1201645 S NA 0Y5M6 Cluster_702200 V1201646 S rRNA biogenesis protein Rrp5 0XUK3 Cluster_44486 V1201647 POLA_2 L DNA polymerase 0XRUF Cluster_31841 V1201648 L phage plasmid primase, p4 family COG3378 Cluster_119887 V1201649 K, L domain protein COG0553 Cluster_560701 V1201650 S NA 11PZU Cluster_542941 V1201651 V Hnh endonuclease COG1403 Cluster_305157 V1201652 COMEA L Competence protein COG1555 Cluster_29570 V1201653 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_61268 V1201654 S NA 11H5S Cluster_30834 V1201657 S NA 126EM Cluster_191656 V1201661 L Reverse transcriptase COG3344 Cluster_537274 V1201663 S toxin secretion phage lysis holin COG4824 Cluster_407 V1201665 U, W Inherit from COG: domain protein COG5295 Cluster_377034 V1201666 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_127483 V1201667 map03060,map03070 U sec-independent protein 0ZXQT Cluster_9756 V1201668 SP_0498 map00511 G endo-beta-N-acetylglucosaminidase COG4724 Cluster_211600 V1201670 S NA 0YA7S Cluster_347300 V1201671 GLNR K transcriptional regulator COG0745 Cluster_310712 V1201672 S NA 17944@proNOG Cluster_502277 V1201677 L DNA alkylation repair enzyme 0YG23 Cluster_475699 V1201678 M RHS repeat-associated core domain protein COG3209 Cluster_762101 V1201680 S Protein of unknown function (DUF3046) 127S9 Cluster_74810 V1201681 F Uracil permease COG2233 Cluster_16333 V1201683 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_773506 V1201686 MSC_0172 L Transposase 0XS5E Cluster_172870 V1201687 FECB map02010 P Periplasmic binding protein COG0614 Cluster_178615 V1201688 S ABC transporter 124C1 Cluster_352045 V1201689 S B3 4 domain protein COG3382 Cluster_66575 V1201690 P Arylsulfatase COG3119 Cluster_113498 V1201691 M Glycosyl transferase family 2 COG0463 Cluster_7815 V1201693 S Inherit from NOG: antigen PG97 COG4886 Cluster_178616 V1201694 AATB map02010 E ABC transporter substrate-binding protein 0XQ2S Cluster_463003 V1201696 S Filamentation induced by cAMP protein fic 11MJJ Cluster_217324 V1201697 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_454931 V1201701 L Pfam:Transposase_11 0ZVJY Cluster_380533 V1201703 CAS1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) COG1518 Cluster_515109 V1201704 PULA map00500,map01100,map01110 G Glycogen debranching enzyme COG1523 Cluster_126095 V1201705 S histidine acid phosphatase 0YPZX Cluster_146506 V1201707 O phage portal protein HK97 family COG4695 Cluster_617811 V1201708 S prophage pi2 protein 38 11U3I Cluster_226620 V1201710 S NA 0ZJXE Cluster_405357 V1201711 MUG L U mismatch-specific DNA glycosylase COG3663 Cluster_87257 V1201713 RARA L recombination factor protein RarA COG2256 Cluster_298169 V1201714 K Transcriptional Regulator, LuxR family 0Y1WM Cluster_22018 V1201715 M Inherit from NOG: Polymorphic outer membrane protein 11KKP Cluster_208345 V1201716 E, G Membrane COG0697 Cluster_268382 V1201717 FMT S decarboxylase family COG1611 Cluster_198878 V1201719 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG2852 Cluster_31081 V1201720 S Inherit from NOG: cytoplasmic protein 17X18@proNOG Cluster_714858 V1201721 S helicase COG3972 Cluster_79783 V1201722 CG2937 E Extracellular solute-binding protein, family 5 COG0747 Cluster_211601 V1201723 GLCK map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G ROK family COG1940 Cluster_176120 V1201724 P Sulfatase COG3119 Cluster_59070 V1201727 Y0750 S Conserved Protein COG1479 Cluster_436911 V1201728 RESA2 O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG0526 Cluster_82536 V1201730 U TraG family COG3505 Cluster_796860 V1201731 S NA 11U17 Cluster_281698 V1201732 map03440 K Divergent AAA domain protein COG2865 Cluster_683057 V1201733 K Inherit from firmNOG: Transcriptional regulator COG2865 Cluster_396537 V1201734 TOPB L Dna topoisomerase COG0550 Cluster_754852 V1201735 TOPB L Dna topoisomerase COG0550 Cluster_11727 V1201739 map00500,map01100 N Alpha-L-fucosidase 0XPGV Cluster_421496 V1201740 YABB map00340,map00350,map00624,map01120 L Methyltransferase COG4123 Cluster_95697 V1201743 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_79476 V1201744 S NA 0YEPS Cluster_10262 V1201745 S NA 126VW Cluster_79153 V1201746 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_172871 V1201747 M glycosyltransferase group 2 family protein COG0463 Cluster_126793 V1201748 S Filamentation induced by cAMP protein fic COG3177 Cluster_166875 V1201750 map02010 P Periplasmic binding protein COG0614 Cluster_363544 V1201752 PCP O Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) COG2039 Cluster_24692 V1201754 S NA 0YRUB Cluster_219613 V1201756 LPLA map00785,map01100 H Lipoate-protein, ligase COG0095 Cluster_57766 V1201759 M Cell wall anchor domain protein 11Q8J Cluster_231249 V1201760 map00130,map01100,map01110 S Methyltransferase 125X9 Cluster_19288 V1201761 PROTEASE map05120 O peptidase, U32 COG0826 Cluster_195292 V1201762 map00051,map00520,map01100 M RmlD substrate binding domain COG1089 Cluster_152040 V1201763 FCL map00051,map00520,map01100 M Nad-dependent epimerase dehydratase COG0451 Cluster_167670 V1201766 S NA 0XPM9 Cluster_309271 V1201767 GPM2 map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_754853 V1201768 INFA J however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) COG0361 Cluster_5487 V1201770 U, W Inherit from COG: domain protein 121KM Cluster_780934 V1201771 ASD map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) COG0136 Cluster_208346 V1201772 map02010 E branched-chain amino acid ABC transporter, permease COG4177 Cluster_10966 V1201776 SP_0498 G endo-beta-N-acetylglucosaminidase COG4724 Cluster_56247 V1201777 S (LipO)protein 1AJ0J@sphNOG Cluster_592558 V1201779 S NA 0XNWW Cluster_724793 V1201781 S NA 0ZDIF Cluster_718124 V1201782 S Inherit from NOG: Plasmid stabilization system 0XUXM Cluster_60388 V1201783 G glycoside hydrolase, family COG1626 Cluster_262953 V1201784 FABD map00061,map01100 I malonyl CoA-acyl carrier protein transacylase COG0331 Cluster_90420 V1201785 U, W domain protein COG5295 Cluster_44833 V1201786 U, W domain protein COG5295 Cluster_300812 V1201789 PUNA map00230,map00240,map00760,map01100,map01110 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) COG0005 Cluster_170314 V1201790 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_99480 V1201791 YEGQ map05120 O Peptidase U32 COG0826 Cluster_352046 V1201792 GNTR K Transcriptional regulator, GntR family COG1802 Cluster_33388 V1201795 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_138984 V1201800 BMUL_5034 S Aminoglycoside phosphotransferase 0ZRQS Cluster_80894 V1020002 S NA 0YENI Cluster_181018 V1020003 T Histidine kinase 0ZPYN Cluster_218219 V1020004 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_282844 V1020007 S NA 0YYM2 Cluster_272111 V1020008 OCAR_7318 map02030,map02040 N Ompa motb domain protein COG1360 Cluster_307652 V1020011 L TatD-related deoxyribonuclease COG0084 Cluster_310433 V1020012 H uba thif-type nad fad binding protein COG1179 Cluster_780079 V1020015 S NA 0ZHU9 Cluster_330207 V1020018 map02010 P Cobalt transport protein COG0619 Cluster_75416 V1020023 PEPD E Dipeptidase COG4690 Cluster_336278 V1020024 S repeat-containing protein COG0457 Cluster_827715 V1020025 TIG O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COG0544 Cluster_424779 V1020026 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_390808 V1020027 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_270814 V1020029 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_188869 V1020030 FADE23 map00071,map00280,map00410,map00640,map01100,map01110,map03320 I acyl-Coa dehydrogenase 0XP8P Cluster_173565 V1020031 FAS map00061,map00350,map00362,map00627,map00642,map00903,map01100,map01120 I synthase COG4982 Cluster_390809 V1020033 S dedA family COG0586 Cluster_501733 V1020034 GLDH S gliding motility-associated lipoprotein GldH 0ZU07 Cluster_237053 V1020037 PURC map00230,map01100,map01110 F SAICAR synthetase COG0152 Cluster_340733 V1020039 SAPB S MgtC SapB transporter COG1285 Cluster_82057 V1020044 PLCN map00562,map00564,map00565,map01100 M phospholipase C COG3511 Cluster_668862 V1020045 S Alpha Beta Hydrolase COG4757 Cluster_79425 V1020046 C Thiol oxidoreductase COG3488 Cluster_262723 V1020048 DAPA map00300,map01100,map01110,map01120,map01230 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) COG0329 Cluster_232203 V1020049 S EamA-like transporter family 0ZWF2 Cluster_373251 V1020050 SDAAB map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase, iron-sulfur-dependent, beta subunit COG1760 Cluster_287054 V1020051 S Porphyromonas gingivalis family protein 11XDU Cluster_65629 V1020053 COMEC S DNA internalization-related competence protein ComEC Rec2 COG2333 Cluster_88973 V1020054 HUTH map00340,map01100 E Histidine ammonia-lyase COG2986 Cluster_201683 V1020055 M Sortase family COG3764 Cluster_247515 V1020056 CPSY K Transcriptional regulator COG0583 Cluster_737189 V1020057 S Orthopoxvirus protein of unknown function (DUF830) 0XXPF Cluster_635911 V1020059 S esterase 1294K Cluster_161895 V1020060 NQRB C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG1805 Cluster_355029 V1020064 MAF D MAF-like protein COG0424 Cluster_677630 V1020067 K RNA Polymerase COG1595 Cluster_192440 V1020068 S Radical SAM superfamily COG0535 Cluster_548273 V1020069 S oxidoreductase 11WN8 Cluster_417559 V1020071 RECX S regulatory protein RecX 125BK Cluster_501734 V1020072 S Secreted protein 11Z2N Cluster_254995 V1020073 O sucraseferredoxin family COG4759 Cluster_328828 V1020074 T stage II sporulation protein 11QTH Cluster_246264 V1020077 YITL S S1 RNA binding domain protein COG2996 Cluster_321093 V1020078 LOLD map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_761320 V1020079 S NA 0ZXH1 Cluster_239634 V1020080 S ParB-like nuclease domain 0ZJMC Cluster_343814 V1020081 S Phosphoadenosine phosphosulfate reductase 0ZVY8 Cluster_146368 V1020082 L integrase family 0XRS7 Cluster_499195 V1020083 S Domain of unknown function (DUF1896) 11Y7P Cluster_394338 V1020085 FOLE map00790,map01100 H GTP cyclohydrolase i COG0302 Cluster_572439 V1020086 S doxx family COG2259 Cluster_250066 V1020087 MT1025 S conserved transmembrane protein 12614 Cluster_374954 V1020092 MIP O Peptidyl-prolyl cis-trans isomerase COG0545 Cluster_339277 V1020093 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_325725 V1020094 RECO map03440 L Involved in DNA repair and RecF pathway recombination (By similarity) COG1381 Cluster_394339 V1020096 HSAB map00984,map01100 S flavin reductase domain protein, FMN-binding COG1853 Cluster_419279 V1020099 DEF J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) COG0242 Cluster_257467 V1020100 K acetyltransferase COG0454 Cluster_217102 V1020102 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_389057 V1020103 M hydrolase, family 25 COG3757 Cluster_61506 V1020104 ECTP P Transporter COG1292 Cluster_376671 V1020106 LEXA K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) COG1974 Cluster_174363 V1020107 PABB map00400,map00790,map01100,map01110,map01230 E, H synthase component I COG0147 Cluster_327289 V1020108 BETP P Transporter COG1292 Cluster_72432 V1020111 map00051,map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 G Glycosyl hydrolase family 20 COG3525 Cluster_243645 V1020113 S SPP1 gp7 family 12A6V Cluster_322668 V1020117 PPGK map00010,map00520,map01100,map01110,map01120 G Polyphosphate glucokinase COG1940 Cluster_387323 V1020118 SUHB map00521,map00562,map01100,map01110,map04070 G inositol monophosphatase COG0483 Cluster_103891 V1020119 S NA 11QTV Cluster_475245 V1020120 TPX O Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) COG2077 Cluster_704616 V1020121 SCLAV_1355 K AsnC family transcriptional regulator COG1522 Cluster_296555 V1020122 MT0809 C fumarate reductase succinate dehydrogenase flavoprotein domain protein COG3573 Cluster_166732 V1020123 MRDA map00550 M Penicillin-binding protein 2 COG0768 Cluster_303365 V1020127 COAX map00770,map01100 K Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) COG1521 Cluster_686550 V1020128 PANC map00410,map00770,map01100,map01110 H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) COG0414 Cluster_698505 V1020129 S Cell division protein ZapA 0YIVA Cluster_695136 V1020130 S NA 0XW6Q Cluster_730719 V1020133 S Signal peptide protein, YSIRK family 1293E Cluster_238351 V1020135 S phage protein 0XQDU Cluster_172706 V1020139 G Major Facilitator superfamily 0XQFH Cluster_339278 V1020140 YFMJ map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120 S Alcohol dehydrogenase zinc-binding domain protein COG2130 Cluster_211384 V1020142 PITA P phosphate transporter COG0306 Cluster_380169 V1020143 YKAA P phosphate transport regulator COG1392 Cluster_82467 V1020145 CYDD map02010 V ABC, transporter COG4988 Cluster_440527 V1020148 HXLB map00030,map00040,map00680,map01100,map01120,map01230 G 6-phospho 3-hexuloisomerase COG0794 Cluster_389058 V1020149 HXLA map00030,map00040,map00680,map01100,map01120,map01230 G 3-hexulose-6-phosphate synthase COG0269 Cluster_647915 V1020151 ORF010 S Staphylococcal protein of unknown function (DUF960) 1265C Cluster_470991 V1020152 CCU S Protein of unknown function (DUF1643) COG4333 Cluster_479817 V1020154 MT3328 S NA 11M1Z Cluster_309017 V1020155 METN map02010 P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COG1135 Cluster_184520 V1020156 AROE map00400,map01100,map01110,map01230 E shikimate dehydrogenase COG0169 Cluster_248823 V1020159 S structural protein 11RQ6 Cluster_293744 V1020161 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_740677 V1020162 RPMC map03010 J 50s ribosomal protein l29 COG0255 Cluster_318123 V1020163 C 4Fe-4S ferredoxin, iron-sulfur binding COG1145 Cluster_454548 V1020164 K RNA Polymerase COG1595 Cluster_132495 V1020166 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_440528 V1020167 HIT F, G Histidine triad (Hit) protein COG0537 Cluster_170171 V1020168 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_184521 V1020169 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_269496 V1020174 PYRF map00240,map01100 F orotidine 5''-phosphate decarboxylase COG0284 Cluster_228717 V1020175 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_116902 V1020181 RNFC C Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) COG4656 Cluster_428583 V1020182 RFBC map00521,map00523,map01100,map01110 M Dtdp-4-dehydrorhamnose 3,5-epimerase COG1898 Cluster_103317 V1020183 S S-layer domain protein 11R54 Cluster_244921 V1020186 FTSX map02010 D Part of the ABC transporter FtsEX involved in cellular division (By similarity) COG2177 Cluster_303366 V1020189 NUCS L Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) COG1637 Cluster_371629 V1020195 map00190 C Nitroreductase COG0778 Cluster_691175 V1020196 ADA L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) COG0350 Cluster_664516 V1020197 S ABC transporter, ATPase COG3044 Cluster_306285 V1020198 TIPA K Transcriptional regulator COG0789 Cluster_664517 V1020199 BMUL_0638 G domain protein COG0662 Cluster_343815 V1020200 CMK map00240,map00410,map00770,map01100,map01110 F Cytidine monophosphate kinase COG0283 Cluster_132631 V1201801 MUTS2 L DNA mismatch repair protein COG0249 Cluster_1886 V1201802 U, W Inherit from COG: domain protein COG5295 Cluster_182072 V1201804 ERYC E DegT DnrJ EryC1 StrS COG0399 Cluster_432950 V1201806 V Restriction modification system DNA (Specificity COG0732 Cluster_416123 V1201807 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_136680 V1201808 AROA map00400,map01100,map01110,map01230 E 3-phosphoshikimate 1-carboxyvinyltransferase COG0128 Cluster_26148 V1201811 V abc transporter permease protein 11F1K Cluster_371935 V1201812 map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_338100 V1201815 S CAAX amino terminal protease family 0XUJM Cluster_309272 V1201816 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_47285 V1201817 S NA 12BGB Cluster_2486 V1201818 S NA 101UU Cluster_50956 V1201820 U, W Domain-Containing protein COG5295 Cluster_45566 V1201821 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_344096 V1201822 Q Methyltransferase COG0500 Cluster_288672 V1201824 map00061,map00072,map00650,map00780,map01040,map01100 I, Q short-chain dehydrogenase reductase COG1028 Cluster_17886 V1201827 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_89054 V1201828 FPRB map00250,map00910,map01100,map01110,map01120,map01230 C reductase COG0493 Cluster_307856 V1201830 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_128179 V1201831 S NA 11R7X Cluster_46140 V1201832 LYTC map00511 S Glycosyl hydrolases family 25 COG5263 Cluster_195293 V1201835 NRNA J phosphoesterase RecJ domain protein COG0618 Cluster_475700 V1201836 S Acyltransferase family 0YFSP Cluster_3706 V1201837 L adenine specific DNA methyltransferase COG4889 Cluster_62898 V1201838 ABIR S abortive phage infection 0XQE9 Cluster_428966 V1201839 AGUB map00330,map01100 S hydrolase, carbon-nitrogen family COG0388 Cluster_197888 V1201840 AGUA map00330,map01100 E Agmatine deiminase COG2957 Cluster_291276 V1201841 RPH map00230,map00240,map01100 J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) COG0689 Cluster_184672 V1201842 M glycosyl transferase group 1 11PET Cluster_473573 V1201844 CKL_1868 S NA 0XRCN Cluster_3328 V1201846 S NA 101UU Cluster_253988 V1201847 RRMJ J Hemolysin A COG1189 Cluster_531586 V1201848 L transposase 0XQMH Cluster_201875 V1201849 S cytosolic protein 0XSPM Cluster_209387 V1201851 S filamentation induced by cAMP protein Fic COG3177 Cluster_53782 V1201854 PGCA map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_3560 V1201855 S NA 101UU Cluster_487236 V1201856 SP_0119 L Nudix family COG0494 Cluster_101136 V1201858 V Type II restriction 0XSKF Cluster_316847 V1201860 CP_0141 S metallophosphoesterase COG1768 Cluster_211602 V1201861 PITA P phosphate transporter COG0306 Cluster_352047 V1201862 YKAA P phosphate transport regulator COG1392 Cluster_3806 V1201863 S NA 0YZ82 Cluster_22019 V1201865 S conjugation system ATPase, TraG family 0XSHU Cluster_18205 V1201867 UVRD2 map03420,map03430 L helicase COG0210 Cluster_484959 V1201868 ELI_1297 O phage portal protein HK97 family COG4695 Cluster_157806 V1201869 ELI_1299 S Phage major capsid protein COG4653 Cluster_11858 V1201871 M Inherit from COG: domain protein COG4932 Cluster_839812 V1201872 S NA 0XXBY Cluster_306543 V1201873 OMP28 M outer membrane protein Omp28 127K8 Cluster_32441 V1201875 map02020,map02030 S Methyl-accepting chemotaxis protein (MCP) signalling domain COG0840 Cluster_221965 V1201876 M Cell wall anchor domain protein 11Q8J Cluster_24066 V1201877 T EAL 0XNMH Cluster_130329 V1201878 M Inherit from NOG: Polysaccharide Biosynthesis Protein 0XP95 Cluster_105182 V1201880 CLCAR_1091 T Histidine kinase COG0642 Cluster_162029 V1201882 CLOSA_0730 V Hnh endonuclease COG1479 Cluster_178617 V1201883 ECORIM L Modification methylase EcoRI 0XPU0 Cluster_294019 V1201884 SCLAV_4781 S Protein of unknown function (DUF3710) 11QDA Cluster_40860 V1201885 DPPD map02010 S ABC transporter COG1123 Cluster_100554 V1201886 PBUG S Xanthine uracil vitamin C permease COG2252 Cluster_174512 V1201888 V ABC transporter transmembrane region COG1132 Cluster_5319 V1201891 U, W Inherit from COG: domain protein 121KM Cluster_255201 V1201892 OCAR_7318 map02030,map02040 N Ompa motb domain protein COG1360 Cluster_5124 V1201894 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_109423 V1201895 PARE L DNA topoisomerase IV subunit B COG0187 Cluster_21849 V1201896 S Inherit from COG: leucine Rich Repeat COG4886 Cluster_170315 V1201898 M Lipopolysaccharide biosynthesis protein-like protein COG3754 Cluster_8953 V1201902 S NA 11QZ9 Cluster_17973 V1201903 L helicase COG1204 Cluster_804971 V1201905 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_291277 V1201907 PGL map00030,map01100,map01110,map01120 G 6-phosphogluconolactonase (EC 3.1.1.31) COG0363 Cluster_542942 V1201909 SCLAV_0149 S Glyoxalase Bleomycin resistance protein (Dioxygenase 1228Z Cluster_289969 V1201910 LSGF M glycosyltransferase COG0463 Cluster_200877 V1201912 PANE map00770,map01100,map01110 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) COG1893 Cluster_36683 V1201913 RLMC map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) COG2265 Cluster_283101 V1201918 S Recombinase 0Y2JQ Cluster_92356 V1201920 L helicase COG4646 Cluster_152041 V1201921 THII map00730,map01100,map04122 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) COG0301 Cluster_300813 V1201926 D CobQ CobB MinD ParA nucleotide binding domain protein COG1192 Cluster_190742 V1201928 U, W Pfam:YadA COG5295 Cluster_162030 V1201931 VPS70 map00360,map01120 Q Coenzyme F390 synthetase-like protein COG1541 Cluster_296766 V1201933 S kila-n, DNA-binding domain 0XPNQ Cluster_177780 V1201934 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_291278 V1201935 S NA 11J85 Cluster_708384 V1201936 L DNA packaging protein 123DA Cluster_184673 V1201937 CLOSA_0730 V Hnh endonuclease COG1479 Cluster_182073 V1201939 V Type I restriction modification DNA specificity domain COG0732 Cluster_219614 V1201940 L recombinase (Phage integrase family) COG0582 Cluster_214993 V1201941 E Amino acid or sugar ABC transport system, permease protein COG1079 Cluster_145708 V1201942 YCEG F aminodeoxychorismate lyase COG1559 Cluster_12075 V1201944 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_103995 V1201945 PYRC map00240,map01100 F dihydroorotase COG0044 Cluster_378813 V1201946 S Endonuclease Exonuclease phosphatase 126QX Cluster_15775 V1201948 PPC map00620,map00680,map00710,map00720,map01100,map01120 C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) COG2352 Cluster_96803 V1201950 GLGA map00500,map01100,map01110,map04973 G Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) COG0297 Cluster_12877 V1201951 U, W Inherit from COG: domain protein COG5295 Cluster_127484 V1201952 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_515111 V1201953 S Transcriptional regulator 11MVX Cluster_22277 V1201954 S NA 0ZHYV Cluster_134260 V1201955 SP_1634 S Protein of unknown function (DUF2974) 0XSVF Cluster_114874 V1201957 CAPA M Capsule synthesis protein COG2843 Cluster_380534 V1201958 S NA 0YB4U Cluster_430933 V1201959 S domain protein 0XNZW Cluster_255202 V1201960 WHIA K May be required for sporulation (By similarity) COG1481 Cluster_197889 V1201962 GLUQ map00860,map00970,map01100,map01110 J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) COG0008 Cluster_260335 V1201963 M group 2 family COG0463 Cluster_226621 V1201965 S Acyltransferase family 0YSHG Cluster_39146 V1201966 S TPR repeat-containing protein COG0457 Cluster_482638 V1201967 S NA 11QRM Cluster_54996 V1201969 S Metalloprotease MEP1-like protein 0XPH7 Cluster_102246 V1201970 ASPA map00250,map00910,map01100 E Aspartate ammonia-lyase COG1027 Cluster_50572 V1201971 map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_96804 V1201972 O m6 family metalloprotease domain protein COG4412 Cluster_392938 V1201973 COBQ S Glutamine amidotransferase COG3442 Cluster_21555 V1201974 S domain protein 0XPXI Cluster_111425 V1201975 FUMC map00020,map00720,map01100,map01110,map01120,map05200,map05211 C fumarate hydratase class II COG0114 Cluster_610393 V1201978 L endonuclease I COG2356 Cluster_16608 V1201979 PACL2 P Atpase, p-type (Transporting), had superfamily, subfamily ic COG0474 Cluster_333524 V1201980 GLPQ map00564 C glycerophosphoryl diester phosphodiesterase COG0584 Cluster_168520 V1201982 S phage protein 0XQDU Cluster_44285 V1201983 L adenine specific DNA methylase COG2189 Cluster_140504 V1201984 map00010,map00710,map01100,map01110,map01120,map01230 G phosphoglycerate kinase COG0126 Cluster_497079 V1201985 SLGD_00064 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_19203 V1201986 ISDE map02010 P (ABC) transporter COG0614 Cluster_198879 V1201987 OPPD E, P ABC transporter COG0444 Cluster_253989 V1201988 MRR V restriction COG1715 Cluster_255203 V1201989 S NA 0XPA9 Cluster_56496 V1201990 ARGS map00970 J arginyL-tRNA synthetase COG0018 Cluster_91857 V1201991 ADHE map00010,map00051,map00071,map00350,map00362,map00363,map00591,map00620,map00621,map00622,map00625,map00626,map00650,map01100,map01110,map01120 C Dehydrogenase COG1454 Cluster_324512 V1201995 RPH map00230,map00240,map01100 J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) COG0689 Cluster_287314 V1201998 S Domain of unknown function (DUF1980) COG3689 Cluster_287315 V1201999 THYA map00240,map00670,map01100 F Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) COG0207 Cluster_256425 V1202000 M glycosyltransferase group 2 family protein COG0463 Cluster_324513 V1202001 GUML S ExoV domain protein 11PEJ Cluster_477903 V1202002 I Lipid kinase, YegS Rv2252 BmrU family COG1597 Cluster_392939 V1202003 K Transcriptional Regulator, LuxR family 0Y1WM Cluster_482639 V1202004 S Protein of unknown function (DUF1312) 0ZY08 Cluster_74811 V1202005 YFJK L domain protein COG1204 Cluster_249038 V1202007 ATPG map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) COG0224 Cluster_58795 V1202009 map02010 V ABC transporter COG1132 Cluster_98431 V1202010 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_762102 V1202011 S NA 0ZXT9 Cluster_762103 V1202012 OCAR_6158 L Terminase, large subunit COG4626 Cluster_287316 V1202013 S Porphyromonas gingivalis family protein 11XDU Cluster_122825 V1202014 S NA 0XSI9 Cluster_357067 V1202016 PYRF map00240,map01100 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) COG0284 Cluster_573134 V1202017 S NA 0Y9Z0 Cluster_231250 V1202018 FADD15 map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG1022 Cluster_27270 V1202019 P TonB-dependent receptor Plug 0XNPQ Cluster_32995 V1202020 S NA 101UU Cluster_71231 V1202026 S NA 0YBPX Cluster_237280 V1202029 PFLX S radical SAM domain protein COG1313 Cluster_284468 V1202031 CCEL_1484 L Integrase COG2801 Cluster_352048 V1202032 WBEW M sugar transferase COG2148 Cluster_61556 V1202033 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG0469 Cluster_375268 V1202035 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_52590 V1202036 HSDS V Restriction modification system DNA (Specificity COG0732 Cluster_33636 V1202037 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_40861 V1202040 S p-loop domain protein COG4928 Cluster_569928 V1202041 HTRA map03010 O protease COG0265 Cluster_34350 V1202042 U, W Pfam:YadA COG5295 Cluster_523099 V1202044 map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_423358 V1202045 map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_228934 V1202046 YFIH S Multi-copper polyphenol oxidoreductase laccase COG1496 Cluster_79784 V1202049 S NA 0YAQZ Cluster_348925 V1202051 S OstA-like protein 11YB4 Cluster_399980 V1202053 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_353713 V1202054 AROF map00400,map01100,map01110,map01230 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) COG0722 Cluster_37799 V1202055 V abc transporter permease protein COG0577 Cluster_232418 V1202056 SP_1634 S Protein of unknown function (DUF2974) 0XSVF Cluster_295424 V1202057 S NA 121T2 Cluster_139774 V1202058 NAGA map00520,map01110 G GlcNAc 6-P deacetylase COG1820 Cluster_391127 V1202061 TRMB C Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_75785 V1202062 OPPA E Extracellular solute-binding protein, family 5 COG0747 Cluster_223146 V1202064 TATD L Hydrolase, tatD family COG0084 Cluster_61269 V1202067 AST S Enterotoxin 0YVWS Cluster_41693 V1202068 U, W Pfam:YadA COG5295 Cluster_762104 V1202069 S NA 0YRIH Cluster_480326 V1202070 K Sigma factor 0YGB2 Cluster_477904 V1202071 G Binding-protein-dependent transport systems inner membrane component COG1175 Cluster_96805 V1202072 S S-layer domain protein 0XS72 Cluster_332034 V1202073 map00730,map01100 H thiamine COG1564 Cluster_796862 V1202074 S Pfam:SirA 0ZMJP Cluster_295425 V1202075 P TonB-dependent receptor Plug 0XNPQ Cluster_79154 V1202078 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_260336 V1202079 S NA 0ZC4R Cluster_421497 V1202080 RIMM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) COG0806 Cluster_375269 V1202082 CKL_1850 K phage regulatory protein, rha family COG3646 Cluster_585889 V1202083 S NA 122IS Cluster_201876 V1202085 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_332035 V1202086 STP T Phosphatase COG0631 Cluster_130330 V1202088 M Cell wall binding repeat 2-containing protein 12D0J Cluster_509836 V1202089 OPPF3 map02010 S ABC transporter COG1123 Cluster_557629 V1202090 Q Methyltransferase COG0500 Cluster_471456 V1202091 L Inherit from COG: transposase COG5444 Cluster_51919 V1202092 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_79785 V1202093 S Conserved domain protein 0Y57B Cluster_189876 V1202094 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_133476 V1202096 S Inherit from COG: ATPase (AAA COG1373 Cluster_665364 V1202097 S toxin-antitoxin system, antitoxin component, ribbon-helix-helix 11U5W Cluster_410662 V1202099 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_55753 V1202100 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_144962 V1202101 OCAR_5891 map00020,map00720,map01100,map01110,map01120,map05200,map05211 P iron permease COG0672 Cluster_291279 V1202102 LPTB map02010 S ABC transporter COG1137 Cluster_174513 V1202104 NAGA map00520,map01110 G GlcNAc 6-P deacetylase COG1820 Cluster_463004 V1202105 ALST E amino acid carrier protein COG1115 Cluster_382303 V1202107 S NA 11VCX Cluster_128889 V1202108 P Sodium/hydrogen exchanger family COG0025 Cluster_67148 V1202109 S Pyrogenic exotoxin B 11S8V Cluster_216119 V1202111 map00330,map01110,map01230 E Ornithine Cyclodeaminase COG2423 Cluster_262954 V1202112 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0847 Cluster_363545 V1202113 GLUC map02010 E ABC transporter COG0765 Cluster_144211 V1202114 S NA 0XSI9 Cluster_250301 V1202115 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_295426 V1202116 SCPA S Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) COG1354 Cluster_63744 V1202117 APRE O Inherit from firmNOG: peptidase S8 and S53, subtilisin, kexin, sedolisin COG4412 Cluster_480327 V1202118 DPS P During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction COG0783 Cluster_394744 V1202119 RPLD map03010 J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) COG0088 Cluster_277691 V1202120 K Transcriptional regulator 11GAC Cluster_408802 V1202121 S Pilin isopeptide linkage domain protein 1274N Cluster_67517 V1202122 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_67518 V1202123 YBIT S ABC transporter, ATP-binding protein COG0488 Cluster_91858 V1202124 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_78406 V1202126 S L,D-transpeptidase catalytic domain COG1376 Cluster_355378 V1202129 ELI_1297 O phage portal protein HK97 family COG4695 Cluster_216120 V1202130 S filamentation induced by cAMP protein fic COG3177 Cluster_72153 V1202132 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_261657 V1202133 E peptidase 0XRNU Cluster_170316 V1202134 MDLA V Abc transporter COG1132 Cluster_396538 V1202135 SSTT E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) COG3633 Cluster_86818 V1202137 RECG map03440 L ATP-dependent DNA helicase recG COG1200 Cluster_318412 V1202138 GG9_0942 L transposase COG2801 Cluster_273701 V1202139 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii subunits gamma and tau COG2812 Cluster_156093 V1202141 V Restriction modification system DNA (Specificity COG0732 Cluster_141257 V1202142 L PP-loop domain protein COG1606 Cluster_330474 V1202144 ISPD map00900,map01100,map01110 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COG1211 Cluster_242520 V1202145 PYRC map00230,map00240,map01100,map01120 F dihydroorotase COG0044 Cluster_82119 V1202146 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_195294 V1202147 MODA map02010 P ABC transporter, periplasmic molybdate-binding protein COG0725 Cluster_234885 V1202148 COBW S cobw p47k family protein COG0523 Cluster_131887 V1202149 HSDS V Restriction modification system DNA (Specificity COG0732 Cluster_167671 V1202150 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_652836 V1202151 V DNA specificity domain COG0732 Cluster_824557 V1202152 S Toxin-antitoxin system, toxin component, HicA family 0XUD5 Cluster_540076 V1202153 S Toxin-antitoxin system, antitoxin component, HicB family 12518 Cluster_389401 V1202155 ALKA map03410 L 8-oxoguanine DNA glycosylase COG0122 Cluster_284469 V1202157 S Domain of unknown function (DUF1836) 0ZWQ6 Cluster_551858 V1202158 RPSI map03010 J 30S ribosomal protein S9 COG0103 Cluster_225496 V1202160 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_208347 V1202161 YERB S secreted protein 11FHM Cluster_214994 V1202166 RBSC map02010,map02030 G abc transporter COG1172 Cluster_141258 V1202167 GLNA map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG0174 Cluster_266977 V1202169 L Transposase COG3464 Cluster_96284 V1202170 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_148816 V1202171 YCHF J gtp-binding protein COG0012 Cluster_97876 V1202173 S NA 0YG6V Cluster_428967 V1202174 U, W Pfam:HIM COG5295 Cluster_105183 V1202175 CAFA map03018 J ribonuclease COG1530 Cluster_146507 V1202177 NTPB map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) COG1156 Cluster_105802 V1202180 U, W Pfam:YadA COG5295 Cluster_105803 V1202181 S Lipase (class 3) 0ZJUJ Cluster_296767 V1202182 YAAO map00310,map00330,map00960,map01100,map01110 E decarboxylase COG1982 Cluster_107626 V1202183 M outer membrane autotransporter barrel domain protein COG3468 Cluster_241150 V1202184 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_606727 V1202186 OCAR_6158 L Terminase, large subunit COG4626 Cluster_108176 V1202187 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_454932 V1202189 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_110049 V1202190 S NA 12D73 Cluster_309273 V1202192 METK S methionine adenosyltransferase 0YTXD Cluster_154448 V1202193 RIBBA map00740,map01100 H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) COG0807 Cluster_241151 V1202194 NIRJ L Pyrroloquinoline quinone biosynthesis protein E COG0535 Cluster_773508 V1202196 S NA 11QY9 Cluster_243867 V1202197 XERC L Integrase COG0582 Cluster_338101 V1202198 PSEH map00350,map00362,map00520,map00627,map00642,map00903,map01120 M pseudaminic acid biosynthesis n-acetyl transferase COG1670 Cluster_198880 V1202200 S NA 11F7I Cluster_566841 V1202201 YHGE S domain protein COG1511 Cluster_259034 V1202202 S Uncharacterized protein conserved in bacteria (DUF2179) COG1284 Cluster_699113 V1202207 S YGGT family 0ZT1Y Cluster_124088 V1202208 ATPA map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) COG1155 Cluster_135872 V1202210 map00680,map01120 S Phosphotransferase 0Y7VB Cluster_430934 V1202211 YBEY map00240,map00983,map01100 F Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) COG0319 Cluster_780936 V1202212 SP_0239 S UPF0210 protein COG2848 Cluster_145709 V1202213 SPR M nlp p60 protein COG0791 Cluster_136681 V1202214 E Hydrolase COG0637 Cluster_237281 V1202215 TRMB C Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_560704 V1202216 S NA 11PZU Cluster_358743 V1202217 K, L domain protein COG0553 Cluster_129607 V1202218 S NA 0ZTYV Cluster_156094 V1202219 L site-specific recombinase, phage integrase family 0ZF8H Cluster_332036 V1202226 MTNN map00270,map01100 F Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) COG0775 Cluster_137468 V1202228 S NA 11NI8 Cluster_252733 V1202230 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_355379 V1202231 CSN1 L crispr-associated protein COG3513 Cluster_303656 V1202232 PLSC map00561,map00564,map01100 I Acyl-transferase COG0204 Cluster_142762 V1202233 FADD15 map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG1022 Cluster_146508 V1202234 CARA map00240,map00250,map01100 F carbamoyl-phosphate synthetase glutamine chain COG0505 Cluster_348926 V1202236 V abc transporter permease protein COG0577 Cluster_423359 V1202237 M Inherit from NOG: domain protein 18B9F@proNOG Cluster_261658 V1202239 ATOB map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map02020 I acetyl-coa acetyltransferase COG0183 Cluster_442944 V1202241 U domain protein COG0653 Cluster_296768 V1202242 K Transcriptional regulator, TetR family 11JD6 Cluster_185554 V1202244 S SusD family 0XPTK Cluster_219616 V1202246 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_687452 V1202247 BMUL_0473 S ABC transporter, permease COG4120 Cluster_191657 V1202249 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_162031 V1202250 S NA 0YZ82 Cluster_344097 V1202252 Q methyltransferase COG0500 Cluster_167672 V1202253 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_394745 V1202254 C radical SAM domain protein COG1032 Cluster_534361 V1202255 YYBT T domain protein COG3887 Cluster_239873 V1202256 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_182980 V1202257 NRNA J phosphoesterase RecJ domain protein COG0618 Cluster_724794 V1202258 D, J addiction module toxin, RelE StbE family COG2026 Cluster_792880 V1202259 PRPC3 T PAS PAC sensor protein COG2208 Cluster_350543 V1202260 FTSK D cell division protein FtsK COG1674 Cluster_295427 V1202261 S Hydrolase COG0561 Cluster_175327 V1202264 FLIC map02020,map02040,map04626,map05132,map05134 N Flagellin COG1344 Cluster_287317 V1202267 Q AmP-dependent synthetase and ligase COG0318 Cluster_200878 V1202270 S helicase COG3972 Cluster_275050 V1202272 STRIC_0432 L Transposase (IS4 family 11HCS Cluster_531587 V1202277 FHAB T Fha domain containing protein COG1716 Cluster_371936 V1202278 U, W YadA domain protein COG5295 Cluster_358744 V1202279 S NA 11NM2 Cluster_185555 V1202280 S Pfam:YadA 0ZHSU Cluster_186472 V1202285 S NA 0YZ82 Cluster_375270 V1202286 THID map00730,map01100 H phosphomethylpyrimidine kinase COG0819 Cluster_251524 V1202287 PCCB map00280,map00630,map00640,map00720,map01100,map01120 I carboxyl transferase COG4799 Cluster_512415 V1202289 SEPF S Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) COG1799 Cluster_259035 V1202290 RECG map03440 L ATP-dependent DNA helicase recg COG1200 Cluster_355380 V1202291 SASC S surface protein 11FPX Cluster_728046 V1202292 V ABC transporter COG1132 Cluster_192591 V1202294 S Membrane 0XPGQ Cluster_194412 V1202295 S NA 101UU Cluster_687453 V1202296 L NA 0YKV1 Cluster_313730 V1202297 S Membrane 11NPN Cluster_271043 V1202298 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_225497 V1202299 FRDB map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020 C succinate dehydrogenase COG0479 Cluster_734598 V1202301 PULA map00500,map01100,map04973 G pullulanase COG1523 Cluster_209388 V1202302 GLNE O, T Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) COG1391 Cluster_758402 V1202303 SCLAV_4542 S UPF0109 protein COG1837 Cluster_203962 V1202306 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_226622 V1202307 S Abi-like protein 11VSQ Cluster_205035 V1202308 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_209389 V1202312 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_303657 V1202314 YLME F alanine racemase domain protein COG0325 Cluster_526032 V1202315 RLML L Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) COG1092 Cluster_211603 V1202316 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_576358 V1202319 S NA 0XWWF Cluster_599551 V1202321 YCHF J gtp-binding protein COG0012 Cluster_428968 V1202324 GSPF map03070 U type ii secretion system COG1459 Cluster_256426 V1202325 PPID O Peptidyl-prolyl cis-trans isomerase COG0760 Cluster_582685 V1202329 YACL S PilT protein domain protein COG4956 Cluster_225498 V1202331 U, W Pfam:YadA COG5295 Cluster_265664 V1202332 MUTS2 map03430 L muts2 protein COG1193 Cluster_226623 V1202333 GLGX map00500,map01100,map01110 G glycogen debranching enzyme glgx COG1523 Cluster_463005 V1202334 BMPD S basic membrane COG1744 Cluster_469322 V1202336 SPAT map02010 V ABC transporter 0XPIZ Cluster_230081 V1202337 DLTA Q AMP-binding enzyme COG1020 Cluster_230082 V1202338 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_708385 V1202340 S NA 11UW8 Cluster_531588 V1202341 NMB1132 S T5orf172 domain 10WZH Cluster_692030 V1202342 DIND S DNA-damage-inducible protein d 0XQQP Cluster_454933 V1202343 CARD K Transcriptional regulator (CarD family COG1329 Cluster_234886 V1202344 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_566842 V1202345 TRA L transposase COG2826 Cluster_318413 V1202346 SOJ D Chromosome Partitioning Protein COG1192 Cluster_863690 V1202347 OPPC P Binding-protein-dependent transport systems inner membrane component COG1173 Cluster_699114 V1202349 S VRR-NUC domain protein 122HE Cluster_644719 V1202351 YGIQ C upf0313 protein COG1032 Cluster_245138 V1202352 XYLS map00052,map00500,map01100 G hydrolase, family 31 COG1501 Cluster_245139 V1202353 U, W Pfam:YadA COG5295 Cluster_245140 V1202354 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_702202 V1202359 S conserved domain protein 11G4D Cluster_396539 V1202360 VEX3 V abc transporter permease protein COG0577 Cluster_401767 V1202361 HSLO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) COG1281 Cluster_363546 V1202364 RSMI G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 Cluster_298170 V1202367 S Family of unknown function (DUF490) 0ZVTR Cluster_534362 V1202368 NRDE map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_458833 V1202369 RPLY map03010 J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) COG1825 Cluster_792881 V1202370 YIDD S Could be involved in insertion of integral membrane proteins into the membrane (By similarity) COG0759 Cluster_515112 V1202371 S NA 0YDZN Cluster_378814 V1202373 NRDF map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_777245 V1202375 GCVR T UPF0237 protein COG3830 Cluster_261659 V1202376 FTSK D cell division protein FtsK COG1674 Cluster_321376 V1202379 E amino acid COG0531 Cluster_603111 V1202380 S NA 11W9N Cluster_292639 V1202383 SSCG_03340 S Membrane COG2860 Cluster_444927 V1202384 UDP map00240,map00983,map01100 F Uridine phosphorylase COG2820 Cluster_458834 V1202387 HRCA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) COG1420 Cluster_284470 V1202389 MENA map00130,map01100,map01110 H 1,4-dihydroxy-2-naphthoate octaprenyltransferase COG1575 Cluster_276383 V1202391 S NA 0YZ82 Cluster_335027 V1202393 MENA map00130,map01100,map01110 H 1,4-dihydroxy-2-naphthoate octaprenyltransferase COG1575 Cluster_412483 V1202394 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_456869 V1202395 S NA 0ZHU9 Cluster_434865 V1202396 DAM map03430 L DNA adenine methylase COG0338 Cluster_283102 V1202397 U, W Pfam:YadA COG5295 Cluster_284471 V1202398 MUTF map02010 V ABC transporter, ATP-binding protein COG1131 Cluster_284472 V1202399 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_350544 V1202400 GLNH map00240,map00983,map01100,map02010 E Extracellular solute-binding protein family 3 COG0834 Cluster_405358 V1202401 RIMP S Required for maturation of 30S ribosomal subunits (By similarity) COG0779 Cluster_285912 V1202403 V efflux transporter, rnd family, mfp subunit COG0845 Cluster_896107 V1202406 DEF J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) COG0242 Cluster_289970 V1202408 S NA 0ZTYV Cluster_352049 V1202410 RECG map03420,map03440 L transcription-repair coupling factor COG1197 Cluster_291281 V1202411 MURD map00471,map00550,map01100 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COG0771 Cluster_294020 V1202412 S NA 0ZHYV Cluster_292640 V1202413 map00550,map01100 M glycosyl transferase, family 51 COG0744 Cluster_292641 V1202414 S NA 101UU Cluster_294021 V1202415 M Cell wall anchor domain protein 11Q8J Cluster_469323 V1202416 YTFP S hi0933 family COG2081 Cluster_554710 V1202417 NDK map00230,map00240,map01100,map01110 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) COG0105 Cluster_504668 V1202419 METI map02010 P ABC transporter, permease COG2011 Cluster_295429 V1202420 KUP P Transport of potassium into the cell (By similarity) COG3158 Cluster_309274 V1202423 V Eco57I restriction-modification methylase COG1002 Cluster_370321 V1202426 S NA 10255 Cluster_652837 V1202427 V FtsX-like permease family 0ZW5X Cluster_380535 V1202428 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_300814 V1202430 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_734599 V1202433 H Transporter COG2978 Cluster_305158 V1202435 CSN1 L crispr-associated protein COG3513 Cluster_305159 V1202436 U, W Pfam:YadA COG5295 Cluster_306544 V1202437 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_306545 V1202438 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_307857 V1202439 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_737896 V1202440 CSPB K Cold shock protein COG1278 Cluster_576360 V1202441 SCLAV_1560 map02010 P ABC transporter COG1122 Cluster_554711 V1202443 PSSA map00260,map00564,map01100 I cdpdiacylglycerol-serine O-phosphatidyltransferase COG1183 Cluster_773509 V1202444 K Inherit from COG: Transcriptional regulator COG3655 Cluster_714860 V1202445 RPLI map03010 J Binds to the 23S rRNA (By similarity) COG0359 Cluster_312247 V1202446 S Possible hemagglutinin (DUF637) 0Y87V Cluster_414341 V1202447 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_434867 V1202450 T Histidine kinase COG5000 Cluster_332037 V1202451 V ABC, transporter COG1131 Cluster_438962 V1202452 TROB map02010 P (ABC) transporter COG1121 Cluster_724795 V1202453 L dna damage-inducible protein 0ZX1H Cluster_523101 V1202458 SLL0832 S Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) 1222S Cluster_718125 V1202459 YRZL S UPF0297 protein COG4472 Cluster_324515 V1202460 S NA 0YBRU Cluster_324516 V1202461 FADD15 map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG1022 Cluster_327578 V1202465 M Cell wall anchor domain protein 11Q8J Cluster_329075 V1202467 PURF map00230,map00250,map01100,map01110 F glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_773510 V1202468 CZRA K Transcriptional regulator, arsr family COG0640 Cluster_499730 V1202469 RAIA J ribosomal subunit Interface protein COG1544 Cluster_542945 V1202471 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_731347 V1202472 RPST map03010 J Binds directly to 16S ribosomal RNA (By similarity) COG0268 Cluster_333525 V1202473 S Domain of unknown function (DUF1837) 1276T Cluster_335028 V1202474 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_338102 V1202477 NTPC map00190,map00680,map01100 C ATP synthase subunit C COG1527 Cluster_338103 V1202478 S NA 11NI8 Cluster_339540 V1202479 F ATP cone domain COG1328 Cluster_678514 V1202480 YHBY J Rna-binding protein COG1534 Cluster_392940 V1202484 DPPC map02010 P ABC transporter (Permease) COG1173 Cluster_339541 V1202485 FRUA map00051,map01100,map02060 G PTS System COG1445 Cluster_537275 V1202486 S Uncharacterized conserved protein (DUF2304) 124N2 Cluster_340991 V1202487 UVRD map03420,map03430 L ATP-dependent DNA helicase PcrA COG0210 Cluster_342518 V1202490 map00550 M Peptidase S13, D-Ala-D-Ala carboxypeptidase C COG2027 Cluster_610396 V1202491 S mobilization protein 11J0G Cluster_344098 V1202492 S ErfK YbiS YcfS YnhG COG1376 Cluster_417929 V1202496 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG0194 Cluster_345732 V1202497 S Amidohydrolase 3 COG1574 Cluster_373551 V1202501 M NA 0YDBK Cluster_812974 V1202502 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_394746 V1202504 MDLA V Abc transporter COG1132 Cluster_357068 V1202505 NTPF S H -ATPase, subunit H 122TR Cluster_357069 V1202506 TNAA map00350,map00380 E tryptophanase EC 4.1.99.1 COG3033 Cluster_428969 V1202507 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_360405 V1202508 HSDR V Type I Restriction COG0610 Cluster_358745 V1202509 MGTE P magnesium transporter COG2239 Cluster_368608 V1202514 TRMB C Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_509837 V1202516 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_363547 V1202520 map01054 Q synthetase COG1020 Cluster_363548 V1202521 U, W Pfam:YadA COG5295 Cluster_365284 V1202524 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_863693 V1202530 P TrkA-N domain protein COG1226 Cluster_368609 V1202532 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_370322 V1202533 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_370323 V1202534 OPPA E ABC transporter COG0747 Cluster_377036 V1202539 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_452908 V1202541 APT map00230,map01100 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) COG0503 Cluster_551859 V1202545 ADDB L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination COG3857 Cluster_419699 V1202546 HPRK T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) COG1493 Cluster_573135 V1202548 MDH map00620,map00710,map01100,map01120,map02020 C malate dehydrogenase (Oxaloacetate-decarboxylating) COG0281 Cluster_384090 V1202549 S NA 11SQP Cluster_480329 V1202550 RIBH map00740,map01100 H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) COG0054 Cluster_384091 V1202553 L DNA Methylase COG2189 Cluster_427078 V1202554 TIG O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COG0544 Cluster_440929 V1202555 YPDP S Membrane COG1738 Cluster_534363 V1202556 MRAY map00550,map01100 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) COG0472 Cluster_387695 V1202557 S NA 0YG6V Cluster_391129 V1202559 G Aamy_C COG1523 Cluster_440930 V1202563 M Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) COG1807 Cluster_392941 V1202565 UMUC L Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) COG0389 Cluster_392942 V1202567 S S-layer domain protein 11R54 Cluster_392943 V1202568 S NA 101UU Cluster_534364 V1202570 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_537276 V1202572 YAAK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) COG0718 Cluster_396540 V1202573 BMUL_2277 L DNA Methylase COG1475 Cluster_509838 V1202574 TRMB S Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_398263 V1202576 S copper amine 0XP8R Cluster_460884 V1202577 S S-layer homology domain 11IK1 Cluster_708387 V1202579 YCGA S c4-dicarboxylate anaerobic carrier COG1288 Cluster_636818 V1202580 ARCC map00230,map00330,map00910,map01120 E carbamate kinase COG0549 Cluster_399981 V1202581 U, W Pfam:YadA COG5295 Cluster_769865 V1202582 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_401769 V1202585 TNPB L transposase COG0675 Cluster_492082 V1202586 PUUR K Transcriptional regulator COG1396 Cluster_403549 V1202588 SAGG map02010 V ABC transporter, ATP-binding protein COG1131 Cluster_699115 V1202590 SP_0058 K GntR family transcriptional regulator COG2188 Cluster_405359 V1202591 GPMI map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0696 Cluster_636820 V1202592 RPST map03010 J Binds directly to 16S ribosomal RNA (By similarity) COG0268 Cluster_407047 V1202594 SUGC map02010 G (ABC) transporter COG3839 Cluster_883947 V1202596 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_407048 V1202597 V ABC transporter ATP-binding COG1132 Cluster_839816 V1202598 MACB V ABC transporter COG1136 Cluster_407049 V1202599 UVRA2 map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_408803 V1202600 M hemolysin erythrocyte lysis protein 2 COG1208 Cluster_812977 V1202603 S NA 1262Z Cluster_414342 V1202604 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_414343 V1202606 S NA 0ZTYV Cluster_554712 V1202607 TRMFO J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) COG1206 Cluster_416125 V1202608 U, W Pfam:YadA COG5295 Cluster_800722 V1202610 CCA map03013,map03018 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate COG0617 Cluster_423360 V1202615 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_423361 V1202616 S trap transporter, 4tm 12tm fusion protein COG4666 Cluster_523102 V1202617 HGDA map00362,map01100,map01120,map01220 E dehydratase COG1775 Cluster_507241 V1202619 MIND D site-determining protein COG2894 Cluster_656965 V1202621 RPLU map03010 J This protein binds to 23S rRNA in the presence of protein L20 (By similarity) COG0261 Cluster_425141 V1202624 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_792882 V1202625 S kila-n, DNA-binding domain 0XPNQ Cluster_425142 V1202627 F Permease family COG2233 Cluster_504669 V1202629 S NA 0YVMU Cluster_507242 V1202631 DNAQ map03022,map03420 L helicase COG1199 Cluster_425143 V1202632 U, W Pfam:HIM COG5295 Cluster_835999 V1202634 RPSU map03010 J 30S ribosomal protein S21 COG0828 Cluster_427079 V1202635 ARCC map00230,map00330,map00910,map01120 E carbamate kinase COG0549 Cluster_427080 V1202636 S Acyltransferase family 12D68 Cluster_427081 V1202637 SSTT E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) COG3633 Cluster_427082 V1202638 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_430935 V1202641 YDBI S Membrane COG0628 Cluster_430936 V1202642 ADK map00230,map00240,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_430937 V1202643 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_430938 V1202645 S NA 0YG6V Cluster_432951 V1202647 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_432952 V1202648 SASC S surface protein 11FPX Cluster_585891 V1202650 S cyclase, family COG1878 Cluster_582688 V1202651 L topoisomerase IV, A subunit COG0188 Cluster_434868 V1202654 S NA 0YZ82 Cluster_436912 V1202655 MODC map02010 P ABC transporter COG1118 Cluster_436913 V1202657 PG0188 S BNR Asp-box repeat protein 11U9Y Cluster_458835 V1202659 S Putative cell wall binding repeat 0YEGX Cluster_499731 V1202661 S NA 0YEF7 Cluster_440931 V1202664 Q amino acid adenylation 0XPD8 Cluster_548956 V1202668 V ABC transporter transmembrane region COG1132 Cluster_442946 V1202670 S NA 0YG6V Cluster_442947 V1202674 Q Condensation domain 0XPD8 Cluster_780938 V1202676 TRPH S PHP domain protein COG0613 Cluster_444928 V1202677 LYTC M hydrolase, family 25 COG3757 Cluster_737897 V1202678 S NA 12BS1 Cluster_566843 V1202679 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_769866 V1202680 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_859302 V1202681 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_512416 V1202682 S Membrane protein of unknown function 0ZIET Cluster_448982 V1202689 U, W Pfam:YadA COG5295 Cluster_625270 V1202690 S NA 0Y87T Cluster_448983 V1202691 S NA 127I3 Cluster_566844 V1202693 GLYQ map00970 J glycyl-tRNA synthetase, alpha subunit COG0752 Cluster_751423 V1202696 YDCK S acetyltransferase YdcK 175BH@proNOG Cluster_452910 V1202701 S NA 0YIZN Cluster_705261 V1202703 K Transcriptional regulator, arsr family 121UH Cluster_452911 V1202704 TRAN S Conjugative transposon TraN protein 0XNQ2 Cluster_454934 V1202705 U, W surface protein COG5295 Cluster_454935 V1202707 PROC map00330,map01100,map01110,map01230 E pyrroline-5-carboxylate reductase COG0345 Cluster_900354 V1202709 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_456870 V1202710 YFJK L domain protein COG1204 Cluster_456871 V1202712 GALU map00040,map00052,map00500,map00520,map01100,map01110 M UTP-glucose-1-phosphate uridylyltransferase COG1210 Cluster_456872 V1202713 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_458836 V1202715 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_731349 V1202717 L Recombinase COG1961 Cluster_502278 V1202719 RPLY map03010 J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) COG1825 Cluster_460885 V1202720 P Spermidine putrescine-binding protein COG1840 Cluster_460886 V1202721 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_737898 V1202723 OPPD map02010 E, P ABC transporter COG0444 Cluster_477906 V1202729 AQPZ G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) COG0580 Cluster_528802 V1202731 GLNE O, T Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) COG1391 Cluster_721435 V1202735 TYRA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydrogenase COG0287 Cluster_467174 V1202736 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_467175 V1202738 S NA 12B21 Cluster_773512 V1202744 S Prolyl oligopeptidase family COG1073 Cluster_469325 V1202746 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_762106 V1202749 YAAA S s4 domain protein COG2501 Cluster_497080 V1202750 PPC map00620,map00680,map00710,map00720,map01100,map01120 C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) COG2352 Cluster_625272 V1202752 TRKA P potassium transporter peripheral membrane COG0569 Cluster_471459 V1202753 L Helicase COG4581 Cluster_471460 V1202754 UBIE map00340,map00350,map00624,map01120 Q methyltransferase COG0500 Cluster_816771 V1202755 map00260,map00290,map01100,map01110,map01230 E Threonine dehydratase COG1171 Cluster_517799 V1202757 RIBH map00740,map01100 H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) COG0054 Cluster_683061 V1202758 FLD C Flavodoxin COG0716 Cluster_484960 V1202759 NRDR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) COG1327 Cluster_473574 V1202760 PYRF map00240,map01100 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) COG0284 Cluster_475704 V1202765 P TonB dependent receptor COG4771 Cluster_475705 V1202766 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_475706 V1202768 P tonB-dependent Receptor COG4206 Cluster_520340 V1202770 YXIO G major facilitator superfamily COG2270 Cluster_640845 V1202771 AZLD E branched-chain amino acid COG1687 Cluster_812979 V1202772 S ATPase (AAA COG1373 Cluster_867738 V1202778 GRDI S reductase 0XPPI Cluster_482640 V1202781 S NA 11FZK Cluster_554713 V1202783 GLTA map00250,map00910,map01100,map01110,map01120,map01230 E Glutamate synthase COG0543 Cluster_551860 V1202786 map02010 E PBPb COG0834 Cluster_484962 V1202787 S Conserved Protein COG4866 Cluster_487238 V1202788 B565_1256 S NA 11JBM Cluster_499732 V1202790 S small multi-drug export COG2426 Cluster_487239 V1202792 PEPP E Xaa-Pro aminopeptidase COG0006 Cluster_487240 V1202793 map02010 V ABC transporter COG1131 Cluster_489591 V1202797 DEDA P SNARE associated Golgi COG0586 Cluster_489592 V1202798 DUSB J Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_492086 V1202802 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_492087 V1202803 DCK map00230,map00240,map01100 F deoxynucleoside kinase COG1428 Cluster_579451 V1202804 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G Phosphohexokinase COG0205 Cluster_492089 V1202806 PPDK map00620,map00710,map01100,map01120 G Pyruvate phosphate dikinase COG0574 Cluster_492090 V1202807 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_492091 V1202809 RPSD map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) COG0522 Cluster_492092 V1202813 S S-layer domain protein 11R54 Cluster_492093 V1202814 Q amino acid adenylation domain protein COG1020 Cluster_809001 V1202815 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_718128 V1202818 S NA 0YSBG Cluster_780940 V1202820 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_497082 V1202822 map03440 K Transcriptional regulator COG2865 Cluster_674055 V1202824 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_863696 V1202828 S membrAne 11GVZ Cluster_499733 V1202830 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_499734 V1202831 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_499735 V1202832 S trap transporter, 4tm 12tm fusion protein COG4666 Cluster_499736 V1202833 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_589191 V1202837 S NA 0YPTE Cluster_502280 V1202839 PHND map02010 P Phosphonate ABC transporter, periplasmic COG3221 Cluster_502281 V1202840 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_504670 V1202842 U, W Pfam:YadA COG5295 Cluster_548957 V1202843 FTSK D cell division protein FtsK COG1674 Cluster_504671 V1202844 ELI_3039 K RNA Polymerase 1261F Cluster_610398 V1202846 YUFP S inner-membrane translocator COG4603 Cluster_504672 V1202849 S SusD family 0XPTK Cluster_507243 V1202852 OPPA E ABC transporter COG0747 Cluster_507244 V1202855 HSDS V restriction modification system DNA specificity domain COG0732 Cluster_582689 V1202859 S Membrane COG4330 Cluster_582690 V1202860 LACZ map00040,map00052,map00500,map00511,map00531,map00600,map00860,map00944,map00983,map01100,map04142 G beta-galactosidase COG3250 Cluster_714863 V1202861 GLNQ E ABC transporter, ATP-binding protein COG1126 Cluster_692031 V1202863 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_512417 V1202864 S conserved domain protein 11Q3F Cluster_589192 V1202865 S NA 0ZHU9 Cluster_687454 V1202866 S NA 0ZHU9 Cluster_512418 V1202874 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_515114 V1202875 NNRE G Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity) COG0062 Cluster_621475 V1202880 S NA 102R7 Cluster_773513 V1202883 YOCS S Bile acid COG0385 Cluster_517800 V1202884 S Protein of unknown function DUF58 COG1721 Cluster_520341 V1202889 ELI_3039 K RNA Polymerase 1261F Cluster_517802 V1202890 TRMK S SAM-dependent methyltransferase COG2384 Cluster_540077 V1202892 GMK2 map00230,map01100 F Guanylate kinase COG0194 Cluster_520342 V1202894 S NA 0YG6V Cluster_520343 V1202895 L RecA-family ATPase COG3598 Cluster_523103 V1202897 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_551861 V1202898 YITW O fes assembly suf system protein COG2151 Cluster_526034 V1202901 AROA map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate synthase COG0128 Cluster_724797 V1202902 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_526035 V1202905 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_528803 V1202906 S Inherit from NOG: domain protein 0XXVB Cluster_531589 V1202907 S Protein of unknown function (DUF3021) 123B1 Cluster_625273 V1202909 C FMN-binding domain protein COG3976 Cluster_908866 V1202910 VANR T response regulator COG0745 Cluster_534367 V1202919 S S-adenosylmethionine-dependent methyltransferase COG1092 Cluster_592559 V1202920 BCRA map02010 V ABC transporter COG1131 Cluster_534368 V1202921 S Domain of unknown function DUF87 0ZJHN Cluster_596028 V1202923 K GntR Family Transcriptional Regulator COG2188 Cluster_534369 V1202925 V HpaII restriction endonuclease 11A91 Cluster_534370 V1202926 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_773514 V1202928 YBAK S YbaK ebsC protein COG2606 Cluster_534371 V1202929 S Nucleotidyl transferase of unknown function (DUF1814) 0XP6B Cluster_576361 V1202931 ETFA map00910 C Electron transfer flavoprotein COG2025 Cluster_540078 V1202935 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_617812 V1202939 GCVR T UPF0237 protein COG3830 Cluster_540079 V1202941 S NA 0ZHU9 Cluster_540080 V1202942 NIRJ L Pyrroloquinoline quinone biosynthesis protein E COG0535 Cluster_540081 V1202943 S Hydrolase COG0561 Cluster_741350 V1202944 CZCD P cation diffusion facilitator family transporter COG0053 Cluster_542946 V1202946 map01040 E lipolytic protein G-D-S-L family COG2755 Cluster_576362 V1202947 map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) COG1156 Cluster_674056 V1202954 CSAB M Polysaccharide pyruvyl transferase COG2327 Cluster_545896 V1202956 S NA 126MH Cluster_542949 V1202957 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_545897 V1202958 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_542950 V1202960 PEPD E Dipeptidase COG4690 Cluster_545898 V1202962 SPOU J rrna methyltransferase COG0566 Cluster_545900 V1202966 DEOD map00230,map00240,map00270,map00760,map01100,map01110 F purine nucleoside phosphorylase DeoD-type COG0813 Cluster_855395 V1202970 H IA, variant 3 COG0637 Cluster_548958 V1202974 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_551862 V1202976 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_551863 V1202977 YICL E, G Transporter COG0697 Cluster_551864 V1202981 THIW S thiw protein COG4732 Cluster_551865 V1202982 ECFA1 map02010 P ABC transporter COG1122 Cluster_648776 V1202983 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_731350 V1202985 S Membrane 0ZTTH Cluster_714864 V1202986 DNAC L DNA replication protein COG1484 Cluster_610399 V1202988 S phage protein 12CZJ Cluster_566845 V1202989 PRIA map03440 L Primosomal protein n' COG1198 Cluster_557630 V1202991 S S-layer domain protein 0XRBV Cluster_557631 V1202993 PPDK map00620,map00710,map01100,map01120 G pyruvate phosphate dikinase COG0574 Cluster_614025 V1202995 COMEA L Competence protein COG1555 Cluster_560707 V1203004 SERP0565 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_560708 V1203006 BL00983 S Phage Portal Protein 11QNG Cluster_563648 V1203010 G transporter major facilitator family protein COG0477 Cluster_563650 V1203014 PEPP E Xaa-Pro aminopeptidase COG0006 Cluster_566846 V1203018 I protein, conserved in bacteria COG3581 Cluster_566849 V1203021 V abc transporter permease protein 0ZW5X Cluster_569929 V1203025 RECG map03440 L ATP-dependent DNA helicase RecG COG1200 Cluster_569930 V1203026 HTPG map04141,map04151,map04612,map04621,map04626,map04914,map04915,map05200,map05215 O Molecular chaperone. Has ATPase activity (By similarity) COG0326 Cluster_569931 V1203027 RACD map00250,map01054 E aspartate racemase COG1794 Cluster_579452 V1203028 DAPB map00300,map01100,map01110,map01120,map01230 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) COG0289 Cluster_569932 V1203030 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_573140 V1203035 map01054 Q synthetase COG0318 Cluster_573141 V1203036 S NA 0YB9V Cluster_714865 V1203037 S NA 11X94 Cluster_573142 V1203038 S HAD hydrolase, family IA, variant 3 COG1011 Cluster_636822 V1203040 FMT S decarboxylase family COG1611 Cluster_640846 V1203042 NNRD G Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) COG0063 Cluster_576364 V1203043 U, W Pfam:YadA COG5295 Cluster_576365 V1203044 FAS map00061,map00350,map00362,map00627,map00642,map00903,map01100,map01120 I synthase COG4982 Cluster_576366 V1203045 S Cell surface protein 0ZXQA Cluster_579453 V1203046 MT2802 S atpase involved in dna repair 0XNTH Cluster_576367 V1203049 MNTH P H( )-stimulated, divalent metal cation uptake system (By similarity) COG1914 Cluster_579454 V1203050 RNMV L Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) COG1658 Cluster_579455 V1203055 SCPA S Segregation and condensation protein COG1354 Cluster_843919 V1203057 S von Willebrand factor, type A 11H48 Cluster_582692 V1203059 Q Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) COG1020 Cluster_582693 V1203063 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_582694 V1203064 CYSM map00260,map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_582695 V1203065 S NA 0ZX1V Cluster_678515 V1203068 PRIA map03440 L Primosomal protein n' COG1198 Cluster_592560 V1203071 GAP map00010,map01100,map01110,map01120,map01230,map04066,map05010 G Glyceraldehyde-3-phosphate dehydrogenase COG0057 Cluster_589193 V1203073 map00240,map00450 O Pyridine nucleotide-disulphide oxidoreductase COG0492 Cluster_718130 V1203074 HPRA map00260,map00630,map00680,map01100,map01110,map01120 C D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain COG1052 Cluster_589194 V1203076 S Methyltransferase small domain 0XZ2E Cluster_589195 V1203077 U, W Pfam:YadA COG5295 Cluster_592561 V1203078 UVRD map03420,map03430 L ATP-dependent DNA helicase pcra COG0210 Cluster_596029 V1203080 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_610400 V1203082 THIJ map05012 T DJ-1 family COG0693 Cluster_592563 V1203083 S adenosylcobinamide amidohydrolase COG1865 Cluster_896114 V1203088 VICR map02020 T response regulator COG0745 Cluster_596031 V1203090 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_596032 V1203091 BGLA1 map00010 G Glycosyl hydrolase family 1 COG2723 Cluster_596033 V1203093 LGAS_0607 T head morphogenesis protein, SPP1 gp7 COG5585 Cluster_599554 V1203094 S NA 0ZVIT Cluster_599555 V1203100 V abc transporter permease protein COG0577 Cluster_596034 V1203101 S NA 0Y8RQ Cluster_621476 V1203104 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_599556 V1203107 IDSA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_599557 V1203108 BL01171 P hemerythrin hhe cation binding domain protein COG2461 Cluster_632780 V1203110 map02010 P Permease protein COG0609 Cluster_705262 V1203112 P CBS domain COG1253 Cluster_603115 V1203113 map00230,map01100 F adenine phosphoribosyltransferase COG0503 Cluster_606728 V1203116 S NA 0ZHU9 Cluster_606729 V1203119 YHBH J sigma 54 modulation protein ribosomal protein S30EA COG1544 Cluster_610402 V1203121 DNAQ2 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit epsilon COG0847 Cluster_610403 V1203122 LGAS_0606 S Phage Portal Protein 0XP33 Cluster_610404 V1203123 S fibronectin type III domain protein 11FT5 Cluster_610405 V1203124 REX K Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) COG2344 Cluster_614026 V1203125 YKNZ V ABC transporter, permease COG0577 Cluster_614027 V1203127 C Na H antiporter COG1757 Cluster_614028 V1203131 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_610406 V1203133 S AP2 domain 123DH Cluster_610407 V1203134 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_617814 V1203137 GG9_0942 L Transposase COG2801 Cluster_617816 V1203139 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_796863 V1203140 S hi0933 family COG2081 Cluster_621478 V1203146 S pathogenesis 0XR1H Cluster_652841 V1203147 S amidinotransferase COG4874 Cluster_644720 V1203150 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_661202 V1203153 map03070 S NA 122A7 Cluster_656966 V1203157 PANF H Sodium pantothenate symporter COG4145 Cluster_628986 V1203158 E, T ABC, transporter COG0834 Cluster_751424 V1203169 YKUD M ErfK ybiS ycfS ynhG family protein COG1376 Cluster_636825 V1203170 S NA 11YG8 Cluster_636826 V1203171 PPDK map00620,map00680,map00710,map00720,map01100,map01120 G Pyruvate phosphate dikinase COG0574 Cluster_674058 V1203174 V abc transporter permease protein COG0577 Cluster_809004 V1203175 S NA 0Z7BP Cluster_692033 V1203176 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_636828 V1203178 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG2812 Cluster_648777 V1203179 L Primosomal protein, DnaI COG1484 Cluster_640847 V1203180 M Choline kinase COG4750 Cluster_883951 V1203181 DCM map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_669684 V1203182 OPPB E, P Oligopeptide ABC transporter, permease protein AppB COG0601 Cluster_636829 V1203183 S Inherit from COG: leucine Rich Repeat COG4886 Cluster_640848 V1203184 L Inherit from COG: DNA Methylase COG0827 Cluster_640849 V1203185 S Pfam:DUF2081 COG1479 Cluster_640850 V1203186 YBHK S UPF0052 protein COG0391 Cluster_644722 V1203190 PILE S TM2 domain containing protein COG2314 Cluster_644724 V1203192 L Resolvase, N terminal domain 123HQ Cluster_644725 V1203195 HLYX P CBS domain protein COG1253 Cluster_648779 V1203197 YBHK S UPF0052 protein COG0391 Cluster_648780 V1203200 S NA 11U85 Cluster_652843 V1203202 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_652844 V1203204 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_652845 V1203205 MURG map00550,map01100,map04112 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) COG0707 Cluster_652846 V1203207 PBP2A map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_652847 V1203209 S NA 0YG6V Cluster_661204 V1203216 S NA 11YT1 Cluster_661205 V1203217 S NA 11NI8 Cluster_661208 V1203220 S Phage portal protein COG4695 Cluster_665368 V1203229 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_777251 V1203230 S NA 11UHB Cluster_665369 V1203233 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_665370 V1203237 NORM V Mate efflux family protein COG0534 Cluster_665371 V1203239 map00680 C Na H antiporter COG1757 Cluster_669685 V1203240 L site-specific recombinase COG1961 Cluster_669687 V1203244 NUSA K Transcription elongation factor NusA COG0195 Cluster_674060 V1203248 PYRK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) COG0543 Cluster_678517 V1203253 CYSK map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_678518 V1203254 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_678519 V1203255 M NA 0YDBK Cluster_714866 V1203258 METE map00270,map00450,map01100,map01110,map01230 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) COG0620 Cluster_683065 V1203262 DEOA map00240,map00983,map01100,map05219 F The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) COG0213 Cluster_687457 V1203263 YTBE map00051,map00363,map00591,map00625,map00650,map01100,map01120 C reductase COG0656 Cluster_687459 V1203268 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (alpha subunit) COG0587 Cluster_687460 V1203269 RPLI map03010 J Binds to the 23S rRNA (By similarity) COG0359 Cluster_724800 V1203276 S NA 0YMVP Cluster_168521 V1203277 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_25113 V1203278 S Lipase (class 3) 0ZJUJ Cluster_157807 V1203280 AMET_0436 S Bacteriophage protein COG3299 Cluster_566850 V1203281 map03060,map03070 U Membrane protein insertase, YidC Oxa1 family COG0706 Cluster_348927 V1203284 map04112 M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) COG1589 Cluster_298172 V1203285 AGAC map00052,map02060 G PTS System COG3715 Cluster_259036 V1203286 MURQ map00520 G Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate COG2103 Cluster_360406 V1203288 I PAP2 Family COG0671 Cluster_126794 V1203291 YAGE E amino acid COG0531 Cluster_469327 V1203292 K Transcriptional regulator CarD family 11TV7 Cluster_828413 V1203296 L Inherit from COG: transposase COG2826 Cluster_10191 V1203297 SCLAV_4759 L DNA helicase COG1112 Cluster_170317 V1203298 YCJV map02010 G Abc transporter COG3839 Cluster_1117 V1203299 S Transglycosylase SLT domain COG5283 Cluster_66288 V1203300 YLOV S dak2 domain fusion protein ylov COG1461 Cluster_287318 V1203302 ERIC P Chloride channel COG0038 Cluster_173707 V1203303 M licD family COG3475 Cluster_131119 V1203304 V Restriction modification system DNA (Specificity COG0732 Cluster_25208 V1203306 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_355381 V1203307 S domain protein 0XNZW Cluster_47109 V1203308 YFMR S abc transporter COG0488 Cluster_139775 V1203309 SP_0145 G Major Facilitator COG0477 Cluster_20613 V1203310 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_174514 V1203311 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_403550 V1203312 YHGE S domain protein COG1511 Cluster_285913 V1203313 YBJB S integral membrane protein COG4858 Cluster_264338 V1203314 PARB K parb-like partition protein COG1475 Cluster_264339 V1203315 NOC K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) COG1475 Cluster_448984 V1203316 S Colicin v production protein 0Y5GJ Cluster_200879 V1203317 YLEB S Outer surface protein COG3589 Cluster_465093 V1203318 L Site-specific recombinase COG1961 Cluster_203963 V1203319 LDCA V peptidase U61 LD-carboxypeptidase A COG1619 Cluster_186473 V1203321 YCHF J gtp-binding protein COG0012 Cluster_108790 V1203322 YFNA E amino acid COG0531 Cluster_355382 V1203323 COBQ S Glutamine amidotransferase COG3442 Cluster_292642 V1203324 THID map00730,map01100 H phosphomethylpyrimidine kinase COG0351 Cluster_20925 V1203325 LEVR K Transcriptional COG3933 Cluster_450957 V1203326 LDH map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120 C L-Lactate dehydrogenase COG0039 Cluster_8197 V1203327 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_177781 V1203328 LGAS_0572 L Integrase COG0582 Cluster_47110 V1203329 BGLF map00500,map02060 G pts system COG2190 Cluster_237282 V1203330 S NA 11GVV Cluster_245141 V1203331 K Transcriptional regulator COG0583 Cluster_250302 V1203332 PEPR map00330 E Releases the N-terminal proline from various substrates (By similarity) 0ZVHU Cluster_234887 V1203333 BSH map00120,map00121,map01100 M Choloylglycine hydrolase COG3049 Cluster_456873 V1203334 S Glycine sarcosine betaine reductase 0ZWHF Cluster_125403 V1203335 E Dipeptidase COG0624 Cluster_93744 V1203336 SCRB map00052,map00500,map01100 G sucrose-6-phosphate hydrolase COG1621 Cluster_769868 V1203338 WECD K acetyltransferase COG0454 Cluster_448985 V1203339 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_239874 V1203341 MLEP3 S auxin efflux carrier COG0679 Cluster_174515 V1203342 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_22437 V1203343 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_438963 V1203344 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_348928 V1203345 T Histidine kinase 0XNMH Cluster_315318 V1203346 COAX map00770,map01100 K Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) COG1521 Cluster_262956 V1203347 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_6130 V1203348 S NA 101UU Cluster_40862 V1203350 DPPD map02010 S ABC transporter COG1123 Cluster_175328 V1203351 ATOB map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map02020 I acetyl-coa acetyltransferase COG0183 Cluster_19106 V1203352 PEPN map00480,map01100 E aminopeptidase N COG0308 Cluster_45762 V1203353 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_171141 V1203355 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_145710 V1203356 GLYA map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01230 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) COG0112 Cluster_31186 V1203357 GALA map00052,map00561,map00600,map00603 G alpha-galactosidase COG3345 Cluster_454936 V1203358 K Transcriptional regulator COG1309 Cluster_227753 V1203359 PANE1 map00770,map01100,map01110 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) COG1893 Cluster_110050 V1203360 D DivIVA protein COG3599 Cluster_444929 V1203361 NQR map00051,map00363,map00591,map00625,map00650,map01100,map01120 S Nadph-dependent fmn reductase COG0431 Cluster_122148 V1203362 GSHR3 map00010,map00020,map00260,map00280,map00480,map00620,map01100,map01110,map01120 C reductase COG1249 Cluster_189012 V1203366 CAS2 L CRISPR-associated protein cas2 11VHR Cluster_137469 V1203367 COMFA L Competence protein COG4098 Cluster_366990 V1203368 L Inherit from COG: Competence protein COG1040 Cluster_110051 V1203369 YIFK E amino acid COG1113 Cluster_106409 V1203370 E amino acid COG0531 Cluster_33119 V1203372 LGAS_0626 S NA 121JZ Cluster_432953 V1203373 LGAS_0625 S Uncharacterized protein conserved in bacteria (DUF2313) 127C4 Cluster_168522 V1203374 XKDT S baseplate J family protein COG3299 Cluster_582697 V1203375 LGAS_0623 S phage protein 1218T Cluster_603116 V1203376 LGAS_0622 S Protein of unknown function (DUF2577) 0XYND Cluster_80966 V1203377 ASPC map00250,map00290,map01100,map01110,map01210,map01230 E Aminotransferase COG0436 Cluster_50957 V1203378 map02020 V ABC transporter, permease COG0577 Cluster_98432 V1203379 E amino acid COG0531 Cluster_340992 V1203380 map02010 V ABC-2 type transporter 1282E Cluster_196955 V1203381 TGT J Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COG0343 Cluster_377037 V1203382 S NA 0XV6C Cluster_166139 V1203383 NAPA P Sodium hydrogen exchanger COG0475 Cluster_407050 V1203385 S integral membrane protein COG5523 Cluster_347301 V1203386 VICR map02020 T response regulator COG0745 Cluster_333526 V1203387 ARAD map00040,map00053,map01100,map01120 G L-ribulose-5-phosphate 4-epimerase COG0235 Cluster_131889 V1203388 HFLX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COG2262 Cluster_242521 V1203389 CYSK map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_12526 V1203390 M Cell surface protein 11GRZ Cluster_477909 V1203391 YJEM E Inner membrane transporter yjeM 174IZ@proNOG Cluster_139776 V1203392 S tail tape measure protein COG5412 Cluster_789094 V1203394 S Tail tape measure protein, TP901 family COG5280 Cluster_548959 V1203395 SP_1924 S NA 0Y6AG Cluster_804974 V1203396 S Single-strand binding protein 11IEM Cluster_163677 V1203397 S NA 11R20 Cluster_573144 V1203399 S NA 12BNJ Cluster_16214 V1203401 V abc transporter permease protein COG0577 Cluster_64838 V1203402 LACE map00052,map01100,map02060 G pts system, lactose-specific COG1455 Cluster_463006 V1203403 LUXS map00270,map05111 T Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) COG1854 Cluster_153647 V1203404 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_299452 V1203405 S osta family 0XUST Cluster_399982 V1203407 YGAC J UPF0374 protein COG3557 Cluster_108791 V1203408 RUMA map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_31082 V1203409 RTPR map00230,map00240,map01100 F Ribonucleoside-triphosphate reductase COG0209 Cluster_448986 V1203410 YVQK S adenosyltransferase COG2096 Cluster_648781 V1203411 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_169454 V1203412 M teichoic acid biosynthesis COG1887 Cluster_99481 V1203413 WZX M polysaccharide biosynthesis protein COG2244 Cluster_350545 V1203414 CPSM map00051 M Polysaccharide biosynthesis protein COG3774 Cluster_110734 V1203415 ENC_19000 map00010 G glycoside hydrolase, family 1 COG2723 Cluster_100555 V1203416 PTCC map00052,map01100,map02060 G pts system COG1455 Cluster_162879 V1203418 YJDB S NA 128F1 Cluster_207226 V1203419 CYDB map00190,map01100,map02020 C cytochrome d ubiquinol oxidase, subunit ii COG1294 Cluster_186474 V1203420 S Filamentation induced by cAMP protein fic COG3177 Cluster_599558 V1203421 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_95202 V1203422 MPTP_1202 S Lysm domain protein 11U6T Cluster_256427 V1203423 PSAA map02010 P ABC transporter COG0803 Cluster_526036 V1203425 AMAA map00360 E Peptidase dimerisation domain COG1473 Cluster_294022 V1203426 LGG_00492 S hydrolase COG0561 Cluster_573145 V1203427 CRCB D Protein CrcB homolog COG0239 Cluster_150442 V1203428 LIAG map02020 S Inherit from NOG: Membrane 0XV6C Cluster_731352 V1203430 GLPF G Major Intrinsic Protein COG0580 Cluster_120613 V1203431 V abc transporter COG1132 Cluster_152042 V1203432 CARA map00240,map00250,map01100 F carbamoyl-phosphate synthetase glutamine chain COG0505 Cluster_63180 V1203433 S Cell Division Protein 0ZINK Cluster_60958 V1203434 CYDC map02010 V (ABC) transporter COG4987 Cluster_182075 V1203435 LGAS_0572 L Integrase COG0582 Cluster_507246 V1203436 LGAS_0574 S Domain of unknown function (DUF955) 0XW04 Cluster_606731 V1203437 DICA K Transcriptional regulator COG1396 Cluster_350546 V1203438 YVOA K (GntR family) (Transcriptional regulator COG2188 Cluster_156095 V1203439 BL01171 P hemerythrin hhe cation binding domain protein COG2461 Cluster_800725 V1203440 SPOU J rrna methyltransferase COG0566 Cluster_186475 V1203441 M Cell surface protein 11GRZ Cluster_75786 V1203442 map02010 V ABC transporter COG1132 Cluster_120614 V1203443 PEPC E aminopeptidase c COG3579 Cluster_592564 V1203444 YTFP S hi0933 family COG2081 Cluster_33876 V1203445 map02020,map02030 S Methyl-accepting chemotaxis protein (MCP) signalling domain COG0840 Cluster_109424 V1203446 PTS36C map00052,map01100,map02060 G PTS system, galactitol-specific IIc component COG3775 Cluster_85114 V1203447 S NA 11VH8 Cluster_360407 V1203448 K Transcriptional regulator COG1737 Cluster_158687 V1203449 SP_0298 S ATPase (AAA COG1373 Cluster_148818 V1203451 DLTB map05150 M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_50761 V1203452 FLGJ N, U flagellar rod assembly protein muramidase flgj COG1705 Cluster_104590 V1203453 LYSA2 M Glyco_25 COG3757 Cluster_126096 V1203454 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_436914 V1203455 J acetyltransferase, (GNAT) family COG1670 Cluster_408804 V1203456 YJBF S SNARE-like domain protein COG0398 Cluster_309275 V1203457 TERC P membrane protein, TerC COG0861 Cluster_11367 V1203458 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit alpha COG0587 Cluster_661212 V1203459 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_287319 V1203460 VEX3 V abc transporter permease protein COG0577 Cluster_319891 V1203461 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_139777 V1203462 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_385849 V1203463 FABG map00061,map00780,map01040,map01100 I reductase 0XNW1 Cluster_87684 V1203464 GNTK map00030,map01100,map01110,map01120 G Gluconate kinase COG1070 Cluster_176121 V1203465 LYTR K TRANSCRIPTIONal COG1316 Cluster_153648 V1203466 G Major Facilitator COG0477 Cluster_542951 V1203467 LGAS_0618 S XkdN-like protein 11VQZ Cluster_497084 V1203468 LGAS_0617 S XkdM protein, phage-like element PBSX 11FZB Cluster_515115 V1203469 RMAI K Transcriptional regulator 0XUB6 Cluster_47492 V1203470 PTBA map02060 G pts system COG2190 Cluster_576368 V1203471 PLSC2 map00561,map00564,map01100 I Acyl-transferase COG0204 Cluster_321377 V1203472 MTSC map02010 P ABC transporter COG1108 Cluster_96285 V1203473 map00052,map01100,map02060 G PTS system, galactitol-specific IIc component COG3775 Cluster_614029 V1203475 YHEA S UPF0342 protein COG3679 Cluster_416127 V1203476 S NA 0YNCM Cluster_243868 V1203477 MANN map00051,map00520,map01100,map02060 G PTS system mannose fructose sorbose family transporter subunit IID COG3716 Cluster_216121 V1203478 MANX map00051,map00520,map01100,map02060 G pts system COG3444 Cluster_300815 V1203485 S Protein of unknown function (DUF1071) 12192 Cluster_345733 V1203487 LDH map00010,map00051,map00270,map00363,map00591,map00620,map00625,map00640,map00650,map01100,map01110,map01120 C Dehydrogenase COG0039 Cluster_125404 V1203488 ASPC map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aspartate aminotransferase COG0436 Cluster_171963 V1203491 S phage protein 0XQDU Cluster_164485 V1203492 AGAS map00250,map00520,map01100,map01110 M isomerase COG2222 Cluster_489593 V1203493 RLMH S Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) COG1576 Cluster_74482 V1203494 YBEC E amino acid COG0531 Cluster_318415 V1203495 SP_1071 S abc transporter atp-binding protein COG1101 Cluster_606732 V1203496 CKL_1914 K Transcriptional regulator 0XUC3 Cluster_163678 V1203501 S von Willebrand factor type 11R5D Cluster_25703 V1203502 M Inherit from COG: peptidase' 0XPHJ Cluster_617817 V1203503 S NA 0ZH06 Cluster_296769 V1203504 SA0315 K SIR2 family COG0846 Cluster_181152 V1203505 YBIR P transporter COG0471 Cluster_38674 V1203506 M Sulfatase COG1368 Cluster_563651 V1203507 SP_0889 S Death-On-Curing Family COG3654 Cluster_640852 V1203509 S Uncharacterised protein family (UPF0150) 101HY Cluster_347303 V1203510 S NA 11SQP Cluster_120615 V1203512 GLYQS map00970 J Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) COG0423 Cluster_245142 V1203513 CORA P transporter COG0598 Cluster_285914 V1203514 L NA 121AE Cluster_507247 V1203515 AMAA map00360 E Peptidase dimerisation domain COG1473 Cluster_62899 V1203516 NPLT map00500,map01100,map04973 G alpha amylase, catalytic region COG0366 Cluster_347304 V1203517 YFNB map00361,map00625,map01100,map01120 S Hydrolase COG1011 Cluster_283103 V1203518 SP_0742 S degv family COG1307 Cluster_152872 V1203521 S mobA MobL 17C5P@proNOG Cluster_299453 V1203523 PHNB map02010 P phosphonate abc transporter COG3639 Cluster_256428 V1203524 G Major Facilitator superfamily 0XT9M Cluster_243869 V1203526 OCAR_6158 L Terminase, large subunit COG4626 Cluster_863700 V1203527 S NA 127RR Cluster_186476 V1203528 S Archaeal ATPase 0ZW9J Cluster_167673 V1203529 LGAS_0607 T head morphogenesis protein, SPP1 gp7 COG5585 Cluster_766088 V1203530 SP_0677 S Bacterial protein of unknown function (DUF910) COG4483 Cluster_332038 V1203531 S Inherit from COG: Hemerythrin HHE cation binding domain protein COG2461 Cluster_205036 V1203532 RFBD map00521,map00523,map01100,map01110 M Dtdp-4-dehydrorhamnose reductase COG1091 Cluster_86377 V1203533 YFNA E amino acid COG0531 Cluster_391131 V1203535 K HTH_XRE COG1974 Cluster_632785 V1203537 Y2191 K Antirepressor COG3617 Cluster_306546 V1203538 YBJI S Hydrolase COG0561 Cluster_257709 V1203539 S NA 11GVV Cluster_104591 V1203540 CLCAR_1091 T Histidine kinase COG0642 Cluster_434870 V1203541 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0470 Cluster_196956 V1203542 V Beta-lactamase class C related penicillin binding protein COG1680 Cluster_361976 V1203543 RNC map03008,map05205 K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) COG0571 Cluster_206117 V1203544 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_231251 V1203545 HPRK T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) COG1493 Cluster_875769 V1203546 INSI L transposase COG2826 Cluster_50157 V1203547 PORAS_0069 L Transposase (IS4 family 0XT1T Cluster_434871 V1203548 SP_0482 S UPF0397 protein COG4720 Cluster_360408 V1203550 ENC_10390 S Membrane COG3819 Cluster_246470 V1203551 SP_0859 S Membrane COG3817 Cluster_380536 V1203552 PCP O Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) COG2039 Cluster_260337 V1203553 PSTA map02010 P phosphate ABC transporter (Permease COG0581 Cluster_218455 V1203554 PSTC map02010 P phosphate abc transporter COG0573 Cluster_373553 V1203555 K transcriptional regulator 0ZMZA Cluster_333527 V1203556 FAT map00061,map01100 I Acyl-ACP thioesterase COG3884 Cluster_89504 V1203557 GLNPH2 E amino acid ABC transporter COG0834 Cluster_77500 V1203558 map02010 V ABC transporter COG1132 Cluster_566851 V1203560 YSLB S hydrocarbon binding protein 121J8 Cluster_523105 V1203561 K Transcriptional regulator 0XYJE Cluster_287320 V1203562 P Ion channel COG1226 Cluster_170318 V1203563 HPK31 T Histidine kinase COG0642 Cluster_292643 V1203564 K Transcriptional regulator 0Y1S3 Cluster_327579 V1203565 ECSA V abc transporter atp-binding protein COG1131 Cluster_281699 V1203566 YQFL S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) COG1806 Cluster_265665 V1203567 SP_2113 S membrAne COG1284 Cluster_463007 V1203568 S NA 11XM2 Cluster_208348 V1203569 NRNA J phosphoesterase RecJ domain protein COG0618 Cluster_119118 V1203570 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01230 G phosphohexose isomerase COG0166 Cluster_276384 V1203571 map04112 M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) COG1589 Cluster_69603 V1203572 S domain protein 0YF83 Cluster_401770 V1203574 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_105184 V1203575 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_231252 V1203576 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G Phosphohexokinase COG0205 Cluster_344099 V1203578 NPDA map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_178618 V1203579 S NA 0Y3BQ Cluster_40237 V1203580 RECG map03440 L ATP-dependent DNA helicase recG COG1200 Cluster_218456 V1203581 S Protein of unknown function (DUF3137) 11MSU Cluster_27179 V1203582 S Rib/alpha-like repeat 10008 Cluster_132632 V1203584 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_396541 V1203590 YKOE S ABC superfamily ATP binding cassette transporter membrane protein COG4721 Cluster_336563 V1203591 S NA 11VCX Cluster_43488 V1203592 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_30232 V1203593 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_504675 V1203598 RUSA L endodeoxyribonuclease RusA COG4570 Cluster_243870 V1203599 PHND map02010 P phosphonate ABC transporter, periplasmic phosphonate-binding protein COG3221 Cluster_191658 V1203600 LGAS_0610 S Major capsid protein 11IJY Cluster_573147 V1203601 LGAS_0611 S NA 0ZD5C Cluster_603117 V1203602 S NA 0ZA04 Cluster_714867 V1203603 GLYQS map00970 J Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) COG0423 Cluster_87258 V1203604 RV3193C S UPF0182 protein COG1615 Cluster_851604 V1203605 O Matrixin COG5549 Cluster_257710 V1203606 MSCS M mechanosensitive ion channel COG0668 Cluster_358746 V1203607 M ErfK YbiS YcfS YnhG COG1376 Cluster_242522 V1203608 LYSA2 M Glyco_25 COG3757 Cluster_329076 V1203613 S tail component COG4722 Cluster_294023 V1203616 S hydrolase COG0561 Cluster_442948 V1203617 map00350,map00362,map00627,map00642,map00903,map01120 J -acetyltransferase COG1670 Cluster_87685 V1203618 YJEM E Inner membrane transporter yjeM 174IZ@proNOG Cluster_168523 V1203619 L Integrase COG0582 Cluster_648783 V1203620 LGG_00800 S NA 11UDD Cluster_163679 V1203621 TNPB L transposase COG0675 Cluster_708392 V1203622 S integral membrane protein 121K9 Cluster_318416 V1203623 LACR K DeoRC COG1349 Cluster_289971 V1203624 LICT K antiterminator COG3711 Cluster_515116 V1203625 Y1855 P asch domain protein COG4405 Cluster_213812 V1203626 PSTC map02010 P phosphate abc transporter COG0573 Cluster_167674 V1203627 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_216122 V1203628 TRXB map00240,map00450 C ferredoxin--nadp reductase COG0492 Cluster_832085 V1203629 map00362,map00621,map00622,map01100,map01120 S Tautomerase enzyme 0XVB0 Cluster_148076 V1203630 HOM map00260,map00270,map00300,map01100,map01110,map01120,map01230 E homoserine dehydrogenase COG0460 Cluster_387696 V1203631 UNG2 L uracil-dna glycosylase COG1573 Cluster_534373 V1203632 L Nudix family COG0494 Cluster_231253 V1203634 L Site-specific recombinase COG1961 Cluster_357070 V1203636 SRTA M (sortase) family COG3764 Cluster_357071 V1203637 GPMA1 map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0588 Cluster_241152 V1203639 I Diacylglycerol kinase COG1597 Cluster_430939 V1203640 WHIA K May be required for sporulation (By similarity) COG1481 Cluster_119888 V1203641 DNAB L replication initiation and membrane attachment protein COG3611 Cluster_142763 V1203642 PYRB map00240,map00250,map01100 F aspartate transcarbamylase COG0540 Cluster_357072 V1203643 LGAS_0620 S domain protein COG1652 Cluster_57767 V1203645 L helicase COG4646 Cluster_152873 V1203646 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_138232 V1203647 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_332039 V1203649 S NA 0XNUC Cluster_410663 V1203651 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_184674 V1203652 YCEG F aminodeoxychorismate lyase COG1559 Cluster_487241 V1203653 S Nitroreductase 1234Z Cluster_373554 V1203657 AROB map00400,map01100,map01110,map01230 E 3-dehydroquinate synthase COG0703 Cluster_477910 V1203658 AROQ map00400,map01100,map01110,map01230 E Catalyzes a trans-dehydration via an enolate intermediate (By similarity) COG0757 Cluster_576369 V1203659 S NA 122IS Cluster_75467 V1203660 PCCB map00280,map00630,map00640,map00720,map01100,map01120 I carboxyl transferase COG4799 Cluster_515117 V1203661 SCLAV_2624 S NA 0YQAJ Cluster_366991 V1203662 CLPP map04112 O ATP-dependent Clp protease, proteolytic subunit COG0740 Cluster_391132 V1203663 LGAS_0609 S Phage minor structural protein GP20 123J7 Cluster_102793 V1203664 TEH_04440 map00052,map01100,map02060 G PTS system, galactitol-specific IIc component COG3775 Cluster_780943 V1203665 RPOZ map00230,map00240,map01100,map03020 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) COG1758 Cluster_582698 V1203667 S NA 0YIA5 Cluster_403551 V1203668 S Relaxase mobilization nuclease 0Y9PG Cluster_843921 V1203669 RPMG2 map03010 J 50S ribosomal protein L33 COG0267 Cluster_116990 V1203670 MPHA S Aminoglycoside phosphotransferase 0YEJ0 Cluster_279052 V1203672 V Type II site-specific deoxyribonuclease 0ZIH9 Cluster_130331 V1203673 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_176947 V1203674 BL02952 S Membrane COG1434 Cluster_416128 V1203675 BL01877 K Transcriptional regulator COG1309 Cluster_728048 V1203676 YOEB S Addiction module toxin, Txe YoeB family COG4115 Cluster_625275 V1203677 YABA S Involved in initiation control of chromosome replication (By similarity) COG4467 Cluster_275051 V1203678 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0470 Cluster_401771 V1203679 map00230 S relA SpoT domain protein COG2357 Cluster_233685 V1203680 BL00740 K transcriptional regulator 0XR9S Cluster_132633 V1203682 MVAS map00072,map00280,map00650,map00900,map01100,map01110 I Hydroxymethylglutaryl-CoA synthase COG3425 Cluster_741351 V1203684 S NA 0Z7KY Cluster_269730 V1203686 YCSE S hydrolase COG0561 Cluster_140505 V1203687 map03420,map03430 L helicase COG3973 Cluster_809005 V1203688 HSDM V type I restriction-modification system COG0286 Cluster_261663 V1203690 LACX map00010,map01110,map01120 G aldose 1-epimerase COG2017 Cluster_339542 V1203691 TRMD map00900,map01100,map01110 J Specifically methylates guanosine-37 in various tRNAs (By similarity) COG0336 Cluster_382304 V1203693 S tpr repeat-containing protein 11U03 Cluster_434872 V1203694 TRML map04122 J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) COG0219 Cluster_644726 V1203696 MUTS2 map03430 L muts2 protein COG1193 Cluster_264340 V1203697 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_305160 V1203700 SCLAV_2513 map04112 L DNA Methylase COG0863 Cluster_195295 V1203703 HRCA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) COG1420 Cluster_180318 V1203704 PEPP map00310,map00780,map01100 E peptidase M24 COG0006 Cluster_228935 V1203705 MVAD map00900,map01100,map01110 I diphosphomevalonate decarboxylase COG3407 Cluster_332040 V1203706 S SAM-dependent methyltransferase 0YNVR Cluster_780944 V1203707 S Phage minor structural protein, N-terminal domain protein 11ZGW Cluster_714868 V1203708 map00500 S K01838 beta-phosphoglucomutase EC 5.4.2.6 COG0637 Cluster_299454 V1203710 PPNK map00760,map01100 G Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) COG0061 Cluster_452912 V1203712 SP_0161 K, T lytTr DNA-binding domain protein COG3279 Cluster_582699 V1203716 S phage tail component domain protein 11VYN Cluster_313731 V1203718 map02010 P cobalt transport COG0619 Cluster_824563 V1203719 S NA 102MI Cluster_636831 V1203720 S NA 0YFUK Cluster_124741 V1203721 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_408805 V1203722 RECR map03440 L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) COG0353 Cluster_531592 V1203723 MRAZ S Cell division protein mraZ COG2001 Cluster_319892 V1203724 YBBM S ABC transporter, permease COG0390 Cluster_327580 V1203726 YHCG V abc transporter atp-binding protein COG1131 Cluster_416129 V1203727 YGCG S of methanol dehydrogenase type COG1512 Cluster_434873 V1203731 S Inherit from NOG: Methyltransferase 0XSGP Cluster_606733 V1203732 S conserved domain protein 11YGQ Cluster_452914 V1203734 S NA 0Y22Q Cluster_463009 V1203735 S NA 0Z3UR Cluster_563652 V1203737 SP_0064 map00051,map00520,map01100,map02060 G pts system COG2893 Cluster_509840 V1203740 HIT map00230,map00240 F, G histidine triad (hIT) protein COG0537 Cluster_766089 V1203741 S Phage terminase small subunit 11F23 Cluster_473577 V1203743 S NA 129FA Cluster_557632 V1203745 S NA 0ZHU9 Cluster_156946 V1203746 TYPA T gtp-binding protein typa COG1217 Cluster_450958 V1203748 RIML map00350,map00362,map00627,map00642,map00903,map01120 J -acetyltransferase COG1670 Cluster_162880 V1203750 VEX1 V ABC transporter, permease COG0577 Cluster_625276 V1203752 S RelB antitoxin 12546 Cluster_499737 V1203755 S ASCH domain 0Y0UK Cluster_223147 V1203759 PIPD E Dipeptidase COG4690 Cluster_610408 V1203762 RPSA map00900,map01100,map01110,map03010 J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) COG0539 Cluster_190743 V1203763 L Pfam:Transposase_11 0YB49 Cluster_734603 V1203766 ACPP I Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) COG0236 Cluster_324517 V1203767 STP T phosphatase COG0631 Cluster_238599 V1203769 COIA S Competence protein COG4469 Cluster_695829 V1203770 SP_0742 S degv family COG1307 Cluster_836004 V1203773 LOLD V abc transporter atp-binding protein COG1136 Cluster_789096 V1203776 map00010 G Cellulase (glycosyl hydrolase family 5) COG2723 Cluster_201877 V1203777 FLIC map02020,map02040,map04626,map05132,map05134 N Flagellin COG1344 Cluster_711476 V1203779 L DNA packaging protein 123DA Cluster_621480 V1203783 S Archaeal ATPase 0ZW9J Cluster_246471 V1203784 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_232419 V1203785 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_209390 V1203786 PPC map00620,map00680,map00710,map00720,map01100,map01120 C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) COG2352 Cluster_502282 V1203787 LSPA map03060 M, U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) COG0597 Cluster_276385 V1203788 G Major Facilitator COG0477 Cluster_321378 V1203789 PURC map00230,map01100,map01110 F SAICAR synthetase COG0152 Cluster_220802 V1203794 S NA 0YRUB Cluster_345734 V1203795 RECG map03440 L ATP-dependent DNA helicase RecG COG1200 Cluster_855400 V1203796 TRMB C Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_773517 V1203799 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_329077 V1203800 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_274818 V1020201 FABI map00061,map00780,map01100 I Enoyl- acyl-carrier-protein reductase NADH COG0623 Cluster_452514 V1020205 ARGG map00250,map00330,map01100,map01110,map01230 E Citrulline--aspartate ligase COG0137 Cluster_426662 V1020206 RAIA J ribosomal subunit Interface protein COG1544 Cluster_53742 V1020207 S Protein of unknown function (DUF935) COG4383 Cluster_585218 V1020208 RPLL map03010 J Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) COG0222 Cluster_340734 V1020209 GLUC map02010 E ABC transporter COG0765 Cluster_142647 V1020211 FUCA map00511 G Alpha-L-fucosidase COG3669 Cluster_334724 V1020212 S Pfam:DUF88 COG1432 Cluster_264077 V1020213 S Glyoxalase Bleomycin resistance protein (Dioxygenase COG3324 Cluster_545234 V1020217 map02010 E Binding-protein-dependent transport system inner membrane component COG1174 Cluster_234680 V1020218 OPUCC map02010 M Glycine betaine COG1732 Cluster_522522 V1020219 OPUCD map02010 E Glycine betaine carnitine choline COG1174 Cluster_557007 V1020221 RPLK map03010 J This protein binds directly to 23S ribosomal RNA (By similarity) COG0080 Cluster_355030 V1020222 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_460460 V1020223 RPLJ map03010 J ribosomal protein l10 COG0244 Cluster_76355 V1020225 ARC map03050 O ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) COG0464 Cluster_227535 V1020226 S NA 0Y8K6 Cluster_112630 V1020227 LMRA map02010 V ABC transporter COG1132 Cluster_677631 V1020228 DACA map00550,map01100 M carboxypeptidase COG1686 Cluster_274819 V1020232 S NA 0XV8P Cluster_432570 V1020233 L Primosomal protein, DnaI COG1484 Cluster_164343 V1020234 TETB G Major Facilitator 0YSYS Cluster_562956 V1020235 PRE S plasmid recombination enzyme 0XTDI Cluster_639970 V1020236 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_371630 V1020237 YEAZ O Peptidase M22 Glycoprotease COG1214 Cluster_256225 V1020238 GALU map00040,map00052,map00500,map00520,map01100,map01110 M UTP-glucose-1-phosphate uridylyltransferase COG1210 Cluster_686551 V1020240 MT2205 S integral membrane protein COG0762 Cluster_458402 V1020241 SEPF S Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) COG1799 Cluster_313422 V1020245 BUTA map00650 C reductase 0XNW1 Cluster_740678 V1020247 RPME2 map03010 J 50s ribosomal protein l31 COG0254 Cluster_345413 V1020249 UPP map00240,map01100 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) COG0035 Cluster_102707 V1020251 AROP E amino acid COG1113 Cluster_138869 V1020252 O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG0526 Cluster_109316 V1020253 BMUL_4579 G Major Facilitator superfamily 0XT0X Cluster_250067 V1020259 map02010 P ABC transporter COG0395 Cluster_450561 V1020260 HSDS V restriction modification system DNA specificity COG0732 Cluster_219433 V1020261 L recombinase (Phage integrase family) COG0582 Cluster_115427 V1020263 S DivIVA domain repeat protein 11XZ2 Cluster_406701 V1020264 NARJ map00910,map01120,map02020 C nitrate reductase molybdenum cofactor assembly chaperone COG2180 Cluster_146369 V1020268 CSE4 L Crispr-associated protein, cse4 family 0Y6PV Cluster_257468 V1020269 DAGK I Diacylglycerol kinase COG1597 Cluster_835267 V1020270 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_548275 V1020271 AROK map00400,map01100,map01110,map01230 E Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) COG0703 Cluster_108061 V1020272 G Inherit from COG: 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process COG0726 Cluster_131004 V1020275 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_242284 V1020276 YCEA J UPF0176 protein COG1054 Cluster_522523 V1020277 HRPA L ATP-dependent helicase COG1643 Cluster_499196 V1020278 PHOR map02020 T Histidine kinase 0XNMH Cluster_103318 V1020279 NUSA K Transcription elongation factor NusA COG0195 Cluster_430570 V1020285 C Electron transport protein COG1142 Cluster_313423 V1020288 H Involved in biosynthesis of the thiamine precursor thiazole (By similarity) COG1635 Cluster_152732 V1020289 BIOF map00780,map01100 H 8-amino-7-oxononanoate synthase COG0156 Cluster_313424 V1020291 YGDL H uba thif-type nad fad binding protein COG1179 Cluster_460461 V1020292 K RNA polymerase sigma-70 factor COG1595 Cluster_208154 V1020293 NITSA_0073 S transposase 11TFP Cluster_215940 V1020294 AES map00363,map00960,map01120 I alpha beta hydrolase fold-3 domain protein COG0657 Cluster_816046 V1020295 TATA map03060,map03070 U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) 0XUF0 Cluster_203744 V1020296 PAFC K Transcriptional regulator COG2378 Cluster_188002 V1020303 M Glycosyl transferase COG0463 Cluster_428584 V1020304 EFP J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) COG0231 Cluster_406702 V1020306 Y0750 S Conserved Protein COG1479 Cluster_266738 V1020307 ISOVA_0221 V HNH endonuclease 11RVB Cluster_517240 V1020308 RPLI map03010 J Binds to the 23S rRNA (By similarity) COG0359 Cluster_432571 V1020310 PYRE map00240,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_765285 V1020311 FSLA Q IucA IucC family protein COG4264 Cluster_452515 V1020312 ASP23 S alkaline shock protein COG1302 Cluster_496540 V1020314 S NA 0Y5S9 Cluster_70180 V1020315 S Inherit from NOG: antigen PG97 COG4886 Cluster_613261 V1020320 SCLAV_2114 S Protein of unknown function (DUF3499) 11VV4 Cluster_163546 V1020321 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_355031 V1020323 S Leucine rich repeat variant 11WCW Cluster_235869 V1020324 LDH map00010,map00270,map00620,map00640,map01100,map01110,map01120 C L-lactate dehydrogenase COG0039 Cluster_166008 V1020325 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_624489 V1020327 MRPC P Monovalent cation H antiporter subunit C COG1006 Cluster_536668 V1020328 MRPB P monovalent cation H antiporter subunit B COG2111 Cluster_616994 V1020333 S NA 0ZHU9 Cluster_489065 V1020337 FOLK map00790,map01100 H 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase COG0801 Cluster_591849 V1020338 FOLB map00790,map01100 H dihydroneopterin aldolase COG1539 Cluster_292367 V1020339 FOLP map00790,map01100 H dihydropteroate synthase COG0294 Cluster_390810 V1020342 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_331776 V1020343 XYL31A G hydrolase, family 31 COG1501 Cluster_217103 V1020344 BGAA map00052,map00511,map00600,map01100 G Glycosyl hydrolase family 2, sugar binding domain protein COG3250 Cluster_299210 V1020345 RADC L DNA repair protein (RadC COG2003 Cluster_309018 V1020347 YBBP S TIGR00159 family COG1624 Cluster_368314 V1020348 ATOA map00072,map00280,map00627,map00640,map00650,map01100,map01120,map02020 I CoA-transferase subunit B COG2057 Cluster_265423 V1020349 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_446569 V1020350 U Biopolymer transport protein exbD tolR 11JQD Cluster_462583 V1020351 S NA 0Y9ZV Cluster_233493 V1020352 S Methyltransferase domain 10114 Cluster_110593 V1020353 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_59289 V1020354 L UvrD REP helicase COG1074 Cluster_428585 V1020355 TDK map00240,map00983,map01100 F thymidine kinase COG1435 Cluster_253791 V1020356 RBSK map00030 G ribokinase COG0524 Cluster_304886 V1020357 MURI map00471,map01100 M Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) COG0796 Cluster_545235 V1020363 YDHG S Domain of unknown function (DU1801) COG5646 Cluster_482152 V1020364 YQGC S Protein of unknown function (DUF456) COG2839 Cluster_91772 V1020365 S NA 1202C Cluster_482153 V1020367 RECX S regulatory protein RecX 11Y5X Cluster_197698 V1020368 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_668863 V1020369 SCLAV_2230 V ABC, transporter COG0577 Cluster_303367 V1020370 SSCG_04863 V abc transporter COG1136 Cluster_212496 V1020371 LPSA S lipopolysaccharide core biosynthesis protein 0ZUPW Cluster_167499 V1020372 MODB map02010 P molybdate abc transporter COG4149 Cluster_415799 V1020373 MODA map02010 P ABC transporter, periplasmic molybdate-binding protein COG0725 Cluster_198720 V1020374 map00540,map01100 M heptosyltransferase COG0859 Cluster_345414 V1020375 S Zinc finger, swim domain protein COG4279 Cluster_366686 V1020376 ZNUC map02010 P (ABC) transporter COG1121 Cluster_264078 V1020378 UPPP map00550 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) COG1968 Cluster_747347 V1020380 S NA 0ZHU9 Cluster_155965 V1020384 M glycosyltransferase group 1 family protein COG0438 Cluster_847147 V1020386 S NA 0ZHU9 Cluster_135733 V1020393 HUTI map00340,map01100 Q imidazolone-5-propionate hydrolase COG1228 Cluster_228718 V1020395 S Prolyl oligopeptidase family COG1073 Cluster_383739 V1020396 PLAV_1224 S NA 0ZTDK Cluster_187170 V1020397 AGUA map00330,map01100 E Agmatine deiminase COG2957 Cluster_218220 V1020399 NARK P Nitrite extrusion protein COG2223 Cluster_245143 V1203801 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_512419 V1203805 FTHC map00670,map01100 H 5-formyltetrahydrofolate cyclo-ligase COG0212 Cluster_489594 V1203806 S NA 0XTEF Cluster_365285 V1203807 S NA 0YMVP Cluster_731356 V1203808 YICL E, G Transporter COG0697 Cluster_394747 V1203810 S CYTH domain COG4116 Cluster_475709 V1203812 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_333528 V1203815 V ABC transporter COG1136 Cluster_492094 V1203818 YJEE S protein family UPF0079, ATPase COG0802 Cluster_809006 V1203823 P Chloride channel COG0038 Cluster_403552 V1203825 map00380,map01100 D amidohydrolase 2 COG2159 Cluster_392944 V1203829 PGSA map00564,map01100 I cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase COG0558 Cluster_548960 V1203831 S virulence-like protein 0ZW8F Cluster_371937 V1203833 GLNP map02010 E amino acid AbC transporter COG0765 Cluster_309276 V1203834 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_310713 V1203836 S conjugation system ATPase, TraG family 0XSHU Cluster_315319 V1203837 SCLAV_1560 map02010 P ABC transporter COG1122 Cluster_747992 V1203838 S NA 11MJM Cluster_324518 V1203842 S NA 0YBRU Cluster_330475 V1203845 P E1-E2 ATPase COG2217 Cluster_329078 V1203846 FADD15 map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG1022 Cluster_695830 V1203847 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_537278 V1203848 MURE map00300,map00550,map01100 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_699116 V1203849 L Inherit from COG: Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) COG0389 Cluster_891954 V1203850 GTCA S Teichoic acid glycosylation protein COG2246 Cluster_515118 V1203851 SP_0319 G isomerase COG0698 Cluster_377039 V1203854 K Transcriptional regulator COG1609 Cluster_375271 V1203855 THRB map00260,map01100,map01120,map01230 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) COG0083 Cluster_777253 V1203856 S Domain of unknown function (DUF955) 0ZI1U Cluster_606734 V1203857 S NA 121PH Cluster_452915 V1203858 S NA 10WM6 Cluster_361977 V1203859 HSDR V Type I Restriction COG0610 Cluster_665372 V1203864 YRZB S UPF0473 protein COG3906 Cluster_800727 V1203865 S NA 0ZHU9 Cluster_371938 V1203866 FADD15 map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG1022 Cluster_371939 V1203867 S NA 10Z69 Cluster_371940 V1203868 E peptidase COG2195 Cluster_473578 V1203872 QACE S small multi-drug export COG2426 Cluster_724804 V1203873 G major facilitator superfamily 0XNN3 Cluster_557634 V1203874 S NA 11TBU Cluster_828414 V1203877 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_380537 V1203878 S Transglycosylase SLT domain COG5283 Cluster_382305 V1203880 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_896119 V1203881 S NA 11PBT Cluster_836005 V1203884 SCLAV_4542 S UPF0109 protein COG1837 Cluster_913004 V1203885 map02010 S YodA lipocalin-like domain 11KBP Cluster_391133 V1203886 U, W Pfam:YadA COG5295 Cluster_758408 V1203888 P tonB-dependent Receptor COG4771 Cluster_458838 V1203889 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_800729 V1203892 S NA 121PH Cluster_737900 V1203894 E amino acid COG0531 Cluster_407051 V1203902 G Alpha-1,2-mannosidase COG3537 Cluster_408806 V1203903 S NA 11QNK Cluster_412485 V1203905 map00052,map00511,map01100 G Glycoside hydrolase family 2 TIM barrel COG3250 Cluster_669689 V1203908 ABIGI S Abortive infection protein AbiGI 11WH3 Cluster_628988 V1203909 YLXM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) COG2739 Cluster_419700 V1203912 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_425144 V1203913 MANY map00051,map00520,map01100,map02060 G PTS System COG3715 Cluster_621482 V1203918 S Domain of unknown function (DUF955) 0ZI1U Cluster_477911 V1203920 DINB L Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) COG0389 Cluster_683069 V1203925 REP L Replication Protein COG5527 Cluster_497085 V1203927 NRDI F Probably involved in ribonucleotide reductase function (By similarity) COG1780 Cluster_754855 V1203928 J endoribonuclease L-psp COG0251 Cluster_434874 V1203932 S relaxase mobilization nuclease domain protein 0XNXG Cluster_436915 V1203933 S Membrane COG0730 Cluster_446966 V1203944 L Integrase 0YTFQ Cluster_446967 V1203945 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_504676 V1203949 S 5'-phosphate oxidase COG3576 Cluster_454937 V1203950 S conjugative transposon protein 0XVMR Cluster_454938 V1203951 L helicase COG4646 Cluster_458840 V1203953 S pathogenesis 0XR1H Cluster_458841 V1203954 SERB map00260,map00680,map01100,map01120,map01230 E phosphoserine phosphatase COG0560 Cluster_904728 V1203959 RNHB map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0164 Cluster_460888 V1203960 S Membrane 11YSX Cluster_460889 V1203961 L Dna topoisomerase COG0550 Cluster_463010 V1203964 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_863702 V1203965 S Phage terminase small subunit 11F23 Cluster_465094 V1203967 S membrane 0Z8C3 Cluster_467177 V1203969 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_573148 V1203970 CDPW8_0150 K Antirepressor COG3645 Cluster_718134 V1203971 S peptidase family M49 0XRK4 Cluster_592565 V1203972 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_471462 V1203974 V abc transporter COG1132 Cluster_592567 V1203978 GLTS E Sodium Glutamate Symporter COG0786 Cluster_475711 V1203979 S NA 0YNH7 Cluster_714870 V1203980 SP_0119 L Nudix family COG0494 Cluster_475712 V1203981 S NA 0YZ82 Cluster_475713 V1203982 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_477912 V1203984 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_534374 V1203986 MSRA O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) COG0225 Cluster_585894 V1203987 BDP_1102 V abc transporter COG1136 Cluster_480331 V1203988 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_517805 V1203991 U TraG family COG3505 Cluster_484964 V1203993 U, W Inherit from COG: domain protein COG5295 Cluster_487242 V1203995 V Restriction modification system DNA (Specificity COG0732 Cluster_487243 V1203996 S NA 0YMVP Cluster_492095 V1203999 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_494574 V1204000 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_494575 V1204003 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_497087 V1204005 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_741353 V1204006 S NA 0ZPY9 Cluster_832088 V1204008 S haloacid dehalogenase-like hydrolase COG0637 Cluster_769872 V1204009 S NA 125NP Cluster_499738 V1204011 N Bacterial flagellin C-terminal helical region COG1344 Cluster_502283 V1204013 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_714871 V1204016 CADA P heavy metal translocating p-type ATPase COG2217 Cluster_809009 V1204018 S NA 0ZHU9 Cluster_509841 V1204019 M outer membrane autotransporter barrel domain protein COG3468 Cluster_515119 V1204021 FRDB map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020 C succinate dehydrogenase COG0479 Cluster_683070 V1204022 S NA 11QPQ Cluster_766091 V1204027 TRAM S conjugative transposon 0YI63 Cluster_523107 V1204033 S NA 0ZTYV Cluster_523108 V1204034 S NA 11GMQ Cluster_847845 V1204035 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_528805 V1204036 S integral membrane protein 11UKN Cluster_526037 V1204040 RPOD K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_526038 V1204041 AHCY map00270,map01100 H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) COG0499 Cluster_741354 V1204042 GALU map00040,map00052,map00500,map00520,map01100,map01110 M UTP-glucose-1-phosphate uridylyltransferase COG1210 Cluster_617818 V1204043 PPX map00230 F, P ppx gppa phosphatase COG1507 Cluster_531593 V1204050 CAS2 L CRISPR-associated protein cas2 11VHR Cluster_531594 V1204053 THRC map00260,map00750,map01100,map01120,map01230 E Threonine synthase COG0498 Cluster_534375 V1204055 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_534376 V1204056 TYRA map00400,map01100,map01110,map01230 E Chorismate mutase COG1605 Cluster_540083 V1204062 BISC map00450,map00780,map01100 C sulfoxide reductase COG0243 Cluster_836007 V1204066 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_592568 V1204067 S Domain of unknown function (DUF3387) 0Z3FV Cluster_545902 V1204068 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_785112 V1204073 DPS P During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction COG0783 Cluster_548961 V1204074 RNC map03008,map05205 K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) COG0571 Cluster_734605 V1204077 COMM O Mg chelatase subunit ChlI COG0606 Cluster_724805 V1204080 RDRB K Transcriptional regulator COG1349 Cluster_751426 V1204085 RARA L recombination factor protein RarA COG2256 Cluster_557637 V1204088 SCLAV_4715 S type i phosphodiesterase nucleotide pyrophosphatase COG1524 Cluster_665373 V1204090 L DNA alkylation repair enzyme COG4912 Cluster_560711 V1204091 AMYA2 map00500 G alpha amylase, catalytic 0XQRS Cluster_596038 V1204093 V Peptidase C39 family COG2274 Cluster_702206 V1204096 YMDB S appr-1-p processing domain protein COG2110 Cluster_859315 V1204102 S NA 0ZHU9 Cluster_569934 V1204104 DPPA map02010 E ABC transporter substrate-binding protein COG4166 Cluster_896125 V1204105 CICA E HAD-superfamily subfamily IB hydrolase COG0560 Cluster_569935 V1204108 S NA 12ATZ Cluster_569936 V1204110 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_573149 V1204112 S Protein of unknown function DUF86 COG2361 Cluster_573150 V1204113 PYRK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) COG0543 Cluster_576371 V1204114 ALGI M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_579457 V1204117 PSTC map02010 P phosphate abc transporter COG0573 Cluster_579458 V1204118 S regulatory protein COG3641 Cluster_582700 V1204120 COMM O Mg chelatase subunit ChlI COG0606 Cluster_585895 V1204125 S radical SAM domain protein 125RF Cluster_585897 V1204127 V Type I site-specific COG4096 Cluster_652850 V1204129 S NA 0YVCN Cluster_836008 V1204131 THID H phosphomethylpyrimidine kinase COG0351 Cluster_656972 V1204134 L DNA binding protein, excisionase family 0YKT7 Cluster_711478 V1204136 S relaxase mobilization nuclease domain protein 0XNXG Cluster_599560 V1204138 U, W Pfam:YadA COG5295 Cluster_596039 V1204139 FBPA K Fibronectin-binding protein COG1293 Cluster_599561 V1204140 WHIA K May be required for sporulation (By similarity) COG1481 Cluster_610411 V1204147 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_610412 V1204148 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_644728 V1204151 P Chloride channel COG0038 Cluster_617819 V1204152 YHAO L DNA repair exonuclease COG0420 Cluster_656973 V1204155 S NA 11U85 Cluster_621484 V1204156 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_632787 V1204161 K regulatoR COG3835 Cluster_640855 V1204164 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_640858 V1204170 ASPC map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aspartate aminotransferase COG0436 Cluster_809011 V1204173 S NA 0ZHU9 Cluster_644729 V1204174 S NA 0ZHU9 Cluster_692036 V1204175 S NA 0XW6Q Cluster_847847 V1204181 GPMA map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0588 Cluster_661213 V1204184 O Erythromycin esterase COG2312 Cluster_836010 V1204193 MUTT L hydrolase COG0494 Cluster_674065 V1204194 PURE map00230,map01100,map01110 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) COG0041 Cluster_683071 V1204211 RBSR K Transcriptional regulator COG1609 Cluster_687463 V1204217 MUTS2 L DNA mismatch repair protein COG0249 Cluster_702207 V1204219 S NA 0XR5V Cluster_233686 V1204220 S alpha beta COG1073 Cluster_140506 V1204221 TRAG map03070 U TraG TraD family protein COG3505 Cluster_826 V1204223 S NA 101UU Cluster_79155 V1204225 YPGD map02010 V ABC transporter COG1132 Cluster_302210 V1204226 YBJB S integral membrane protein COG4858 Cluster_165330 V1204227 HSDS V DNA specificity domain protein COG0732 Cluster_219617 V1204228 L recombinase (Phage integrase family) COG0582 Cluster_78783 V1204229 HSDM V Type I restriction-modification system, M subunit COG0286 Cluster_18411 V1204231 INLJ map05150 M Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps 1215X Cluster_537279 V1204242 K Peptidase S24-like protein COG2932 Cluster_450959 V1204246 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_30835 V1204252 U traE protein COG3451 Cluster_89055 V1204259 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) COG0438 Cluster_135873 V1204260 UMUC L ImpB MucB SamB family protein COG0389 Cluster_579459 V1204261 S NA 0XZJN Cluster_85115 V1204266 S NA 11H3W Cluster_250303 V1204267 SRTA M (sortase) family COG3764 Cluster_221966 V1204278 YPUA S secreted protein COG4086 Cluster_236083 V1204279 REP L Replication Protein COG5527 Cluster_313732 V1204280 S integral membrane protein 11QKN Cluster_5604 V1204287 S Pfam:TraG 11F36 Cluster_9228 V1204294 S Lpxtg-motif cell wall anchor domain protein 0XQBH Cluster_332041 V1204295 M Cell wall-associated hydrolase COG1388 Cluster_25114 V1204298 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_146509 V1204299 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_209391 V1204306 PSTC map02010 P phosphate abc transporter COG0573 Cluster_77812 V1204307 S Type IV secretion-system coupling protein DNA-binding domain 0YAV5 Cluster_106410 V1204313 WANG_0286 L Transposase COG2963 Cluster_22438 V1204316 PBP1A map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_355383 V1204317 MPTP_1202 S Lysm domain protein 11U6T Cluster_189013 V1204318 XERS L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) COG0582 Cluster_60389 V1204322 L Domain protein COG0507 Cluster_178619 V1204323 DAM map03430 L DNA adenine methylase COG0338 Cluster_515122 V1204334 MSRB O reductase COG0229 Cluster_566852 V1204335 S 5'-phosphate oxidase COG3576 Cluster_410664 V1204344 BSEL_0787 S Phage terminase small subunit COG3747 Cluster_50358 V1204345 ELI_1296 L Terminase, large subunit COG4626 Cluster_171964 V1204347 S Phage Portal Protein COG4695 Cluster_344101 V1204348 map04112 O ATP-dependent Clp protease, proteolytic subunit COG0740 Cluster_135060 V1204349 S phage major capsid protein, HK97 family 0XTEI Cluster_330476 V1204352 S Major tail protein 0Y77V Cluster_209392 V1204356 ENDA S DNA-entry nuclease 12175 Cluster_394749 V1204358 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_711480 V1204363 HUP L DNA-binding protein COG0776 Cluster_387697 V1204365 K regulatoR 0XUX9 Cluster_294024 V1204367 YXEH S hydrolase COG0561 Cluster_233687 V1204368 LACC map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G tagatose-6-phosphate kinase COG1105 Cluster_318417 V1204369 LACR2 K transcriptional regulator DeoR family COG1349 Cluster_507248 V1204370 PTS36A map00052,map01100,map02060 G PTS System COG1762 Cluster_110736 V1204372 PTS36C map00052,map01100,map02060 G PTS system, galactitol-specific IIc component COG3775 Cluster_313734 V1204374 map00051 G class II Aldolase COG0235 Cluster_266978 V1204379 METQ map02010 P Lipoprotein COG1464 Cluster_7801 V1204380 M Inherit from NOG: Cell Wall 1248X Cluster_375272 V1204384 LEPB map03060 U Signal peptidase i COG0681 Cluster_24570 V1204385 TOPB L Dna topoisomerase COG0550 Cluster_284473 V1204386 S Pfam:Phage_integr_N 0YI69 Cluster_148077 V1204392 S NA 0ZIMM Cluster_509843 V1204399 LACZ map00052,map00511,map00600,map01100 G beta-galactosidase COG3250 Cluster_517806 V1204400 L terminase (Small subunit) COG3747 Cluster_133477 V1204401 L Integrase COG0582 Cluster_227754 V1204404 S NA 0XU6J Cluster_392945 V1204405 K HTH_XRE COG1974 Cluster_769873 V1204406 CRO K HTH_XRE 0XYF7 Cluster_394751 V1204412 map00230 S relA SpoT domain protein COG2357 Cluster_370324 V1204413 PHOP map02020 T Transcriptional regulatory protein, C terminal 11FPD Cluster_139778 V1204414 S Membrane COG1808 Cluster_239875 V1204416 map02010 S ABC transporter COG4152 Cluster_318418 V1204417 S ABC-2 type transporter 11FXW Cluster_378816 V1204421 LDB1079 L integrase family COG0582 Cluster_315321 V1204431 YDHQ K Transcriptional regulator COG2188 Cluster_6396 V1204432 S Transglycosylase SLT domain COG5283 Cluster_167675 V1204434 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_678525 V1204435 K Transcriptional regulator 11VW1 Cluster_734606 V1204437 S NA 120D2 Cluster_741358 V1204439 HTH_0473 L Transposase COG0675 Cluster_603119 V1204442 SP_1143 S Toxin-antitoxin system, toxin component, RelE family COG4679 Cluster_721440 V1204443 K HTH_XRE 0XUC3 Cluster_260338 V1204446 LYS M Glyco_25 COG3757 Cluster_112760 V1204448 DSY2934 L Transposase 1012J Cluster_377041 V1204451 S NA 0YUG9 Cluster_692037 V1204454 ORFL L transposase COG2826 Cluster_656976 V1204455 S NA 0XVT8 Cluster_310714 V1204456 PNUC2 H nicotinamide mononucleotide transporter COG3201 Cluster_448990 V1204461 S Archaeal ATPase 0ZW9J Cluster_614032 V1204464 CHPA T transcriptional modulator of maze toxin, mazf COG2337 Cluster_517807 V1204465 HTH_0473 L Transposase COG0675 Cluster_582704 V1204467 L Inherit from COG: transposase COG2826 Cluster_231254 V1204472 S NA 123XQ Cluster_7873 V1204473 S phage tape measure protein COG5283 Cluster_292644 V1204476 S NA 0XNUC Cluster_469328 V1204478 DPNA L helicase COG4646 Cluster_144963 V1204479 L DnaB-like helicase C-terminal domain protein COG0305 Cluster_469329 V1204481 LDB1085 S NA 0YWIA Cluster_32308 V1204487 M NA 0YESU Cluster_456876 V1204488 FRVA map00051,map01100,map02060 G PTS System COG1762 Cluster_34779 V1204490 MTLR K TRANSCRIPTIONal COG3711 Cluster_191659 V1204495 map02020 T Histidine kinase COG2972 Cluster_231255 V1204497 S Protein of unknown function (DUF805) 0ZYU9 Cluster_31503 V1204502 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_127485 V1204503 YPDC S Conserved Protein COG3538 Cluster_302211 V1204507 map03440 K Transcriptional regulator 0XRI9 Cluster_721441 V1204510 map00051,map00052,map00520,map01100,map02060 G PTS System COG2893 Cluster_859318 V1204513 BH0311 L Transposase COG3328 Cluster_39950 V1204519 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_261665 V1204520 K Transcriptional regulator, ARAC family COG4753 Cluster_502284 V1204521 SP_1996 T Universal stress protein COG0589 Cluster_260339 V1204522 S Protein of unknown function (DUF3737) 0XTHF Cluster_347306 V1204527 CKL_1850 K phage regulatory protein, rha family COG3646 Cluster_582705 V1204529 S VRR-NUC domain protein 0Z445 Cluster_16269 V1204532 PACL P cation-transporting atpase COG0474 Cluster_585898 V1204533 S VRR-NUC domain protein 0Z445 Cluster_344102 V1204540 S NA 0XNUC Cluster_329079 V1204544 K AntA/AntB antirepressor COG3645 Cluster_820532 V1204546 CRO K HTH_XRE 0XYF7 Cluster_632788 V1204551 S NA 122AV Cluster_652852 V1204555 S UPF0145 protein COG0393 Cluster_289972 V1204556 S ABC superfamily ATP binding cassette transporter, permease 0YYAC Cluster_302212 V1204559 BL03485 K phage protein 121ZT Cluster_116992 V1204566 L helicase COG1061 Cluster_728052 V1204569 S phage protein 124IT Cluster_27779 V1204571 BL03493 L phage plasmid primase, p4 family COG4983 Cluster_414345 V1204573 BMUR_1332 S Domain of Unknown Function (DUF1599) 0XXR0 Cluster_497089 V1204574 S VRR-NUC domain protein 0Z445 Cluster_276386 V1204582 LYC M glycoside hydrolase, family 25 11T0J Cluster_599562 V1204585 SP_1143 S Toxin-antitoxin system, toxin component, RelE family COG4679 Cluster_132634 V1204586 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_284474 V1204587 D DivIVA protein COG3599 Cluster_15223 V1204588 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_403553 V1204589 NUDF map00230 F nudix hydrolase COG0494 Cluster_353714 V1204591 MTNN map00270,map01100 F Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) COG0775 Cluster_166876 V1204592 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_287321 V1204594 NADE map00760,map01100 H nh(3)-dependent nad( ) synthetase COG0171 Cluster_442949 V1204595 YFBM K acetyltransferase COG0454 Cluster_509844 V1204596 YEBR T gaf domain protein COG1956 Cluster_306547 V1204597 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_8648 V1204599 S Lpxtg-motif cell wall anchor domain protein 0XQBH Cluster_17141 V1204600 MGTA P magnesium-translocating p-type atpase COG0474 Cluster_450960 V1204601 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0847 Cluster_76094 V1204602 E amino acid COG0531 Cluster_262957 V1204603 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_419701 V1204604 XPT map00230,map01100,map01110 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) COG0503 Cluster_66856 V1204605 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_182982 V1204606 PEPP map00310,map00780,map01100 E peptidase M24 COG0006 Cluster_284475 V1204607 S integral membrane protein COG1284 Cluster_579463 V1204609 GG9_0529 S Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) 1248I Cluster_589198 V1204611 S NA 11GVV Cluster_832090 V1204612 map00362,map00621,map00622,map01100,map01120 S Tautomerase enzyme 0XVB0 Cluster_875777 V1204613 YJHA S Endonuclease Exonuclease phosphatase 0XNVA Cluster_640862 V1204614 YJHA S Endonuclease Exonuclease phosphatase 0XNVA Cluster_656977 V1204615 YJHA S Endonuclease Exonuclease phosphatase 0XNVA Cluster_57019 V1204616 S Membrane 0Y3RG Cluster_702208 V1204617 CINI S Hydrolase COG1073 Cluster_257711 V1204618 CAS2 L CRISPR-associated protein cas2 11VHR Cluster_236084 V1204619 CAS1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) COG1518 Cluster_375273 V1204620 CASE L crispr-associated protein 0XPHC Cluster_338104 V1204621 CAS5E L crispr-associated protein 11JEJ Cluster_180319 V1204622 CSE4 L Crispr-associated protein, cse4 family 0Y6PV Cluster_405360 V1204623 CASB S CRISPR system CASCADE complex protein CasB 0ZXJT Cluster_121385 V1204625 S Transglycosylase SLT domain COG5283 Cluster_551869 V1204627 S phage Tail Protein 129AY Cluster_398265 V1204628 V prophage pi1 protein 32 COG1403 Cluster_196145 V1204633 YABB map00340,map00350,map00624,map01120 L Methyltransferase COG4123 Cluster_392946 V1204634 PLSC map00561,map00564,map01100 I Acyl-transferase COG0204 Cluster_165331 V1204635 CFA M cyclopropane-fatty-acyl-phospholipid synthase COG2230 Cluster_166877 V1204636 S Outer surface protein COG3589 Cluster_154449 V1204638 S Abortive infection protein COG1106 Cluster_95698 V1204639 HSDM V type I restriction-modification system COG0286 Cluster_28352 V1204640 MALZ map00052,map00500,map01100 G Alpha-glucosidase COG1501 Cluster_260340 V1204643 K Transcriptional regulator 0Y1S3 Cluster_721442 V1204644 TXE S Addiction module toxin, Txe YoeB family COG4115 Cluster_632790 V1204646 S Inherit from COG: Protein of unknown function (DUF1093) COG5294 Cluster_358747 V1204649 COBQ S Glutamine amidotransferase COG3442 Cluster_551870 V1204650 S Addiction module antitoxin, RelB DinJ family 0XUTM Cluster_12289 V1204652 M Cell surface protein 11GRZ Cluster_592569 V1204655 STRIC_0432 L Transposase (IS4 family 11HCS Cluster_345736 V1204656 FRLR K (GntR family) (Transcriptional regulator COG2188 Cluster_225499 V1204657 G oxidoreductase COG0673 Cluster_344103 V1204658 DEOC map00030 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) COG0274 Cluster_554716 V1204659 K PemK-like protein 0ZMEC Cluster_67519 V1204660 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_421499 V1204662 S Sel1 repeat COG0790 Cluster_205037 V1204664 S NA 0Z1CQ Cluster_517808 V1204666 S HIRAN domain 0XVUM Cluster_176122 V1204667 map03420,map03430 S UvrD/REP helicase N-terminal domain 174DY@proNOG Cluster_70538 V1204668 S NA 0XR66 Cluster_108792 V1204669 AMET_0416 S Phage-associated protein, HI1409 family COG3567 Cluster_355384 V1204670 AMET_0417 S Phage head morphogenesis protein COG2369 Cluster_166878 V1204672 AMET_0418 S Uncharacterized protein conserved in bacteria (DUF2213) COG3566 Cluster_232420 V1204674 AMET_0420 S Uncharacterized protein conserved in bacteria (DUF2184) COG4834 Cluster_375274 V1204676 AMET_0423 S NA 120SA Cluster_129608 V1204679 AMET_0426 S Protein of unknown function (DUF3383) 11UPU Cluster_531596 V1204680 AMET_0427 S NA 0XUEQ Cluster_210467 V1204683 S LysM domain 0YPBZ Cluster_191660 V1204685 AMET_0433 S NA 11WKE Cluster_158688 V1204688 AMET_0436 S Bacteriophage protein COG3299 Cluster_156096 V1204690 PLNI S CAAX amino terminal protease family 0XW1D Cluster_300816 V1204692 COF S Hydrolase COG0561 Cluster_321379 V1204694 OPPA E ABC transporter COG0747 Cluster_515125 V1204696 S Gcn5-related n-acetyltransferase 1221G Cluster_39300 V1204704 FRUA map00051,map01100,map02060 G PTS System COG1445 Cluster_103997 V1204705 map02020 T Histidine kinase COG2972 Cluster_122826 V1204706 ALL2459 S ATP GTP Binding Protein 0XQ3U Cluster_30953 V1204707 L DEAD DEAH box helicase COG1201 Cluster_120616 V1204708 CELB map00052,map01100,map02060 G Pts system COG1455 Cluster_414346 V1204709 BL03733 map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_373555 V1204710 S Antibiotic biosynthesis monooxygenase 0Y2XH Cluster_358748 V1204711 GLPQ map00564 C glycerophosphoryl diester phosphodiesterase COG0584 Cluster_315322 V1204716 K anti-repressor COG3645 Cluster_148819 V1204717 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_737904 V1204718 YAGE E amino acid COG0531 Cluster_77813 V1204719 map02010 V ABC transporter COG1132 Cluster_7098 V1204720 S inulin fructotransferase 0XRZB Cluster_3607 V1204721 ELI_1307 M phage tail tape measure protein COG5283 Cluster_545904 V1204722 GALA map00052,map00561,map00600,map00603 G alpha-galactosidase COG3345 Cluster_181153 V1204723 MSMK map02010 G ABC transporter, ATP-binding protein COG3839 Cluster_57514 V1204724 C Fumarate reduCtase COG1053 Cluster_103419 V1204725 YFLS P transporter COG0471 Cluster_262958 V1204726 MLER K malolactic fermentation system COG0583 Cluster_54997 V1204727 C Fumarate reduCtase COG1053 Cluster_266979 V1204728 MLER K malolactic fermentation system COG0583 Cluster_678527 V1204729 S NA 11GVV Cluster_507250 V1204730 S NA 11GVV Cluster_246472 V1204731 COAA map00770,map01100 H pantothenic acid kinase COG1072 Cluster_465096 V1204732 BL02883 S Membrane 0XVF5 Cluster_327581 V1204733 SDAAB map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase, iron-sulfur-dependent, beta subunit COG1760 Cluster_18858 V1204734 ADHE map00010,map00051,map00071,map00350,map00362,map00363,map00591,map00620,map00621,map00622,map00625,map00626,map00650,map01100,map01110,map01120 C Dehydrogenase COG1454 Cluster_157809 V1204741 M n-acetylmuramoyl-l-alanine amidase 11R58 Cluster_436919 V1204742 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_5057 V1204753 M Cell surface protein 11GRZ Cluster_10082 V1204754 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_322940 V1204755 CADA P p-type atpase COG2217 Cluster_540085 V1204756 ACIN_0074 L Transposase COG3464 Cluster_734609 V1204757 S Membrane 0XQ7F Cluster_232421 V1204758 SCRR K Transcriptional regulator COG1609 Cluster_70887 V1204760 OPPA map02010 E Extracellular solute-binding protein, family 5 COG4166 Cluster_138233 V1204761 HFLX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COG2262 Cluster_205038 V1204762 S NA 11VH8 Cluster_46354 V1204768 MUTL map03430 L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) COG0323 Cluster_1546 V1204771 M Cell surface protein 11GRZ Cluster_313735 V1204772 SBND G Major Facilitator 0ZVCH Cluster_79477 V1204773 LMRB P Drug resistance transporter EmrB QacA 0XNN3 Cluster_78110 V1204774 map02010 V ABC transporter COG1132 Cluster_319893 V1204776 map00350,map00362,map00627,map00642,map00903,map01120 J -acetyltransferase COG1670 Cluster_335029 V1204777 C nitroreductase COG0778 Cluster_243871 V1204778 APPC map02010 P ABC superfamily ATP binding cassette transporter ABC protein COG1173 Cluster_209393 V1204779 OPPD E, P ABC transporter COG0444 Cluster_111427 V1204781 YGCS G Major Facilitator superfamily 0XQKC Cluster_72154 V1204783 OPPA map02010 E Extracellular solute-binding protein, family 5 COG4166 Cluster_228936 V1204785 G oxidoreductase COG0673 Cluster_21077 V1204788 UVRA map03420 L excinuclease COG0178 Cluster_45951 V1204789 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_56497 V1204790 MDLB map02010 V ABC transporter COG1132 Cluster_59071 V1204791 MDLA map02010 V ABC transporter transmembrane region COG1132 Cluster_780947 V1204792 YNEF S UPF0154 protein COG3763 Cluster_724806 V1204793 SP_1473 S UPF0291 protein COG4224 Cluster_162881 V1204794 DGOD map00052 M Galactonate dehydratase COG4948 Cluster_573151 V1204795 TPX O Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) COG2077 Cluster_785114 V1204796 L Transposase COG2826 Cluster_285915 V1204797 S ABC superfamily ATP binding cassette transporter, permease 0YYAC Cluster_155289 V1204798 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_92357 V1204799 S NA 120ST Cluster_188171 V1204800 XERS L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) COG0582 Cluster_548962 V1204802 YPHH map00362,map01100,map01120 S Cupin 2, conserved barrel domain protein COG1917 Cluster_423363 V1204803 YFDE C L-carnitine dehydratase bile acid-inducible protein F COG1804 Cluster_62625 V1204804 OXC map00630,map01100 E oxalyl-CoA decarboxylase COG0028 Cluster_305162 V1204805 PLNI S CAAX amino terminal protease family 0XW1D Cluster_171142 V1204806 E amino acid COG0531 Cluster_809013 V1204807 DSY2934 L Transposase 1012J Cluster_371941 V1204808 I PAP2 Family COG0671 Cluster_249039 V1204810 S Protein of unknown function (DUF805) 0ZYU9 Cluster_21404 V1204811 PBP1A map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_322941 V1204815 GLNQ map02010 E ABC transporter, ATP-binding protein COG1126 Cluster_576374 V1204816 RFBP M exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase (EC 2.7.8.6) COG2148 Cluster_731362 V1204817 CPSE M transferase COG2148 Cluster_387698 V1204818 YJDB S NA 128F1 Cluster_358750 V1204821 RDGB map00230,map00240,map01100 F Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) COG0127 Cluster_416133 V1204823 S NA 0YPVV Cluster_800734 V1204824 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_213813 V1204825 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_471464 V1204826 YJEE S protein family UPF0079, ATPase COG0802 Cluster_219618 V1204827 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_78784 V1204829 FADX map00620,map00640,map00643,map01100,map01120 I CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) COG4670 Cluster_295430 V1204830 K Transcriptional regulator COG0583 Cluster_695833 V1204833 MSMG map02010 P ABC transporter COG0395 Cluster_124089 V1204834 RUMAL_1137 L Transposase COG3436 Cluster_37489 V1204835 COMA map02010,map02020 V ATP-binding protein COG2274 Cluster_569941 V1204840 DXS map00730,map00900,map01100,map01110 H, I Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) COG1154 Cluster_283104 V1204841 DXS map00730,map00900,map01100,map01110 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) COG1154 Cluster_678528 V1204842 HXLR K Transcriptional regulator COG1733 Cluster_523112 V1204843 SP_0161 K, T lytTr DNA-binding domain protein COG3279 Cluster_344104 V1204844 ORFL L transposase COG2826 Cluster_126796 V1204849 PBUG S Xanthine uracil vitamin C permease COG2252 Cluster_83003 V1204850 S ABC transporter, ATP-binding protein COG0488 Cluster_434876 V1204852 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_614033 V1204857 K transcriptional Regulator LysR family 11Z5Z Cluster_97877 V1204858 LDB1095 map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020 C Fumarate reduCtase COG1053 Cluster_711486 V1204864 S Filamentation induced by cAMP protein fic COG3177 Cluster_124742 V1204870 YKGC map00010,map00020,map00260,map00280,map00480,map00620,map01100,map01110,map01120 C pyridine nucleotide-disulfide oxidoreductase COG1249 Cluster_77814 V1204871 YPGD map02010 V ABC transporter COG1132 Cluster_277692 V1204873 S NA 11GVV Cluster_762118 V1204877 S NA 0ZHU9 Cluster_256430 V1204887 MURQ map00520 G Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate COG2103 Cluster_110053 V1204888 ENC_19000 map00010 G glycoside hydrolase, family 1 COG2723 Cluster_731364 V1204900 G Drug resistance transporter EmrB QacA 0XNN3 Cluster_25599 V1204913 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_628989 V1204916 CHPA T transcriptional modulator of maze toxin, mazf COG2337 Cluster_98962 V1204924 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_145711 V1204934 LYS M Glyco_25 COG3757 Cluster_147278 V1204942 SP_1634 S Protein of unknown function (DUF2974) 0XSVF Cluster_589199 V1204962 ERIC P Chloride channel COG0038 Cluster_193475 V1204965 H UBA THIF-type NAD FAD binding protein COG0476 Cluster_728054 V1204970 S NA 0ZHU9 Cluster_178620 V1204971 LGAS_0572 L Integrase COG0582 Cluster_72155 V1204979 SP_1222 V restriction endonuclease 0ZVJ1 Cluster_573152 V1204988 S NA 0ZHU9 Cluster_855406 V1204994 S NA 0ZHU9 Cluster_450961 V1204997 S NA 0ZHU9 Cluster_606736 V1205000 S NA 0ZHU9 Cluster_579466 V1205001 S NA 0ZHU9 Cluster_606737 V1205022 SBND G Major Facilitator 0ZVCH Cluster_335030 V1205032 S NA 123QA Cluster_661218 V1205039 S NA 0ZHU9 Cluster_149584 V1205060 G Drug resistance transporter EmrB QacA 0XNN3 Cluster_780953 V1205061 S NA 0ZHU9 Cluster_589200 V1205082 S NA 0ZHU9 Cluster_105185 V1205088 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_463012 V1205115 S NA 0ZHU9 Cluster_773523 V1205133 S NA 0ZHU9 Cluster_656979 V1205139 S NA 0ZHU9 Cluster_614035 V1205154 COMA map02010,map02020 V Peptidase C39 family COG2274 Cluster_401773 V1205155 COMA map02010,map02020 V ATP-binding protein COG2274 Cluster_661219 V1205210 S NA 0ZHU9 Cluster_391135 V1205221 S NA 0ZHU9 Cluster_599564 V1205244 S NA 17D58@proNOG Cluster_820542 V1205255 S NA 0ZHU9 Cluster_731366 V1205258 S NA 0ZHU9 Cluster_370326 V1205268 S NA 0ZHU9 Cluster_632797 V1205284 S NA 0ZHU9 Cluster_702213 V1205310 S NA 0ZHU9 Cluster_534379 V1205313 S NA 0ZHU9 Cluster_714880 V1205314 S NA 0ZHU9 Cluster_477914 V1205322 S NA 0ZHU9 Cluster_839842 V1205355 S NA 0ZHU9 Cluster_699121 V1205358 S NA 0ZHU9 Cluster_430944 V1205362 S NA 0ZHU9 Cluster_737907 V1205412 S NA 0ZHU9 Cluster_851615 V1205430 BL00144 L Transposase COG2801 Cluster_754868 V1205464 S NA 0ZHU9 Cluster_419702 V1205479 S NA 0YK7B Cluster_812995 V1205499 S NA 0ZHU9 Cluster_382309 V1205527 S NA 0ZHU9 Cluster_537282 V1205531 S NA 0ZHU9 Cluster_569942 V1205534 S NA 0ZHU9 Cluster_515128 V1205544 COMA map02010,map02020 V ATP-binding protein COG2274 Cluster_534382 V1205583 S NA 0ZHU9 Cluster_430945 V1205649 S NA 0ZHU9 Cluster_683077 V1205665 S NA 0ZHU9 Cluster_748006 V1205668 S NA 0ZHU9 Cluster_804991 V1205684 S NA 0ZHU9 Cluster_762134 V1205749 S NA 0ZHU9 Cluster_780965 V1205769 S NA 0ZHU9 Cluster_800742 V1205774 S NA 0ZHU9 Cluster_563656 V1205792 S NA 0ZHU9 Cluster_296556 V1020402 map00270,map00330,map00410,map00480,map01100 S synthase 0ZXB1 Cluster_458403 V1020406 S Htaa 11VMG Cluster_250068 V1020407 S (LipO)protein 11K11 Cluster_585219 V1020408 YUT E UreA transporter COG4413 Cluster_668864 V1020411 L DNA Repair Protein COG2003 Cluster_799889 V1020412 S NA 0Z727 Cluster_106309 V1020413 GLMU map00520,map01100,map01110 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) COG1207 Cluster_235870 V1020415 OPPC P Binding-protein-dependent transport systems inner membrane component COG1173 Cluster_71462 V1020416 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_204849 V1020417 ECORIM L Modification methylase EcoRI 0XPU0 Cluster_133337 V1020418 PURA map00230,map00250,map01100 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis COG0104 Cluster_79091 V1020419 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_147942 V1020421 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_334725 V1020422 C domain protein 0ZQ9H Cluster_446570 V1020423 M Polysaccharide Biosynthesis Protein 0XP95 Cluster_475246 V1020427 FTN map00860 P ferritin COG1528 Cluster_479818 V1020429 T Histidine kinase COG4585 Cluster_343816 V1020430 T HTH_LUXR COG2197 Cluster_548276 V1020431 ALDA map00010,map00040,map00053,map00071,map00280,map00281,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00626,map00640,map00903,map01100,map01110,map01120 C Aldehyde dehydrogenase family COG1012 Cluster_61755 V1020432 AAP map05150 M surface protein 0XSC2 Cluster_444549 V1020433 YKOE S ABC superfamily ATP binding cassette transporter membrane protein COG4721 Cluster_268127 V1020434 FBA map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01230 G Fructose-1,6-bisphosphate aldolase, class II COG0191 Cluster_380170 V1020435 map00230 S mutt nudix family protein 11RXE Cluster_677632 V1020436 YCHJ S UPF0225 protein COG3012 Cluster_142648 V1020437 map02010 M abc transporter permease protein COG4591 Cluster_85464 V1020441 NADE map00760,map01100 H Nad synthetase COG0388 Cluster_639972 V1020442 HXLR K Transcriptional regulator COG1733 Cluster_364934 V1020443 RGAI101_28 L transposase COG3316 Cluster_148696 V1020444 U, W Pfam:YadA COG5295 Cluster_129476 V1020448 M RHS repeat-associated core domain protein COG3209 Cluster_322669 V1020449 DAPB map00300,map01100,map01110,map01120,map01230 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) COG0289 Cluster_202716 V1020450 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_707770 V1020451 S NA 11EPN Cluster_682168 V1020452 RPSN map03010 J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) COG0199 Cluster_436498 V1020453 RPLE map03010 J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COG0094 Cluster_660315 V1020454 RPLX map03010 J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) COG0198 Cluster_494044 V1020455 S NA 0ZHU9 Cluster_209199 V1020456 RLUD J Pseudouridine synthase COG0564 Cluster_562958 V1020457 INV1 M NLP P60 protein COG0791 Cluster_213600 V1020458 MOXR S Atpase associated with various cellular activities aaa_3 COG0714 Cluster_720766 V1020459 RV1480 S von Willebrand factor COG1721 Cluster_560061 V1020460 TRMFO J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) COG1206 Cluster_238352 V1020464 CZCD P cation diffusion facilitator family transporter COG1230 Cluster_496541 V1020465 S Terminase, large subunit COG1783 Cluster_260124 V1020469 E, G Membrane COG0697 Cluster_620747 V1020470 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_724152 V1020471 RPSR map03010 J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) COG0238 Cluster_63418 V1020479 L Inherit from COG: Helicase COG1112 Cluster_327290 V1020481 S transporter gate domain protein 0XRV8 Cluster_127367 V1020484 map00521,map00562,map01100,map01110 I inositoL-3-phosphate synthase COG1260 Cluster_112631 V1020485 RAGB S RagB SusD domain protein 0XZ44 Cluster_63696 V1020486 P tonB-dependent Receptor 0XP5Y Cluster_701606 V1020487 S NA 0Y1Q6 Cluster_73073 V1020489 G transporter major facilitator family protein 0XRD8 Cluster_426663 V1020490 THIJ S intracellular protease Pfpi family COG0693 Cluster_153497 V1020491 HFLC O SPFH domain, Band 7 family protein COG0330 Cluster_548277 V1020492 NFED O, U Membrane protein implicated in regulation of membrane protease activity COG1585 Cluster_406703 V1020493 RIBE map00740,map01100 H riboflavin synthase, subunit alpha COG0307 Cluster_374955 V1020494 PGLC M Bacterial sugar transferase COG2148 Cluster_446571 V1020495 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_281464 V1020496 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_413986 V1020497 S Acetyltransferase (GNAT) family 0ZX86 Cluster_525410 V1020498 RPLK map03010 J This protein binds directly to 23S ribosomal RNA (By similarity) COG0080 Cluster_348645 V1020499 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_413987 V1020500 S NA 11FTP Cluster_227536 V1020508 map00030 G PfkB domain protein COG0524 Cluster_69543 V1020509 P tonB-dependent Receptor COG4771 Cluster_525411 V1020510 FOLK map00790,map01100 H 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase COG0801 Cluster_297929 V1020511 FECE map02010 P abc transporter COG1120 Cluster_73453 V1020522 L Pfam:Transposase_7 COG4644 Cluster_151882 V1020523 ICD map00020,map00480,map00720,map01100,map01110,map01120,map01210,map01230,map04146 C isocitrate dehydrogenase (NADP) COG0538 Cluster_496542 V1020525 S NA 0YGJM Cluster_609619 V1020527 ESTA S esterase COG0627 Cluster_396210 V1020528 RPLC map03010 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 Cluster_138870 V1020529 DINB L Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) COG0389 Cluster_296557 V1020530 VICX map03013 S domain protein COG1235 Cluster_406704 V1020533 MAF D Maf-like protein COG0424 Cluster_788388 V1020534 K XRE family transcriptional regulator 0XUC3 Cluster_97260 V1020537 COBN map00860,map01100 H cobaltochelatase, cobn subunit COG1429 Cluster_265424 V1020538 HEMG map00860,map01100,map01110 H protoporphyrinogen oxidase COG1232 Cluster_351757 V1020539 YWFI S chlorite dismutase COG3253 Cluster_251304 V1020540 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_240922 V1020541 I Lipid kinase, YegS Rv2252 BmrU family COG1597 Cluster_343817 V1020542 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_278834 V1020543 S Pfam:DUF1812 0YDYP Cluster_470992 V1020544 S NA 0YUF4 Cluster_65059 V1020545 IROC map02010 V abc transporter COG1132 Cluster_450563 V1020546 POLA_2 L DNA polymerase 0XRUF Cluster_444551 V1020547 S Phage-associated protein 11FS5 Cluster_819688 V1020549 S phage protein 0XQDU Cluster_194234 V1020550 S NA 126RX Cluster_394340 V1020553 RPOS map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_602313 V1020554 SCLAV_1038 S integral membrane protein COG3162 Cluster_296558 V1020562 PUNA map00230,map00240,map00760,map01100,map01110 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) COG0005 Cluster_152733 V1020563 ROCD map00300,map00330,map01100,map01110,map01120,map01210,map01230 E Catalyzes the interconversion of ornithine to glutamate semialdehyde (By similarity) COG4992 Cluster_591850 V1020564 S NA 0ZJP4 Cluster_65630 V1020565 PKNG map05152 T Serine Threonine protein kinase COG0515 Cluster_147943 V1020567 M Putative cell wall binding repeat 2 COG2247 Cluster_250069 V1020568 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG0582 Cluster_578757 V1020569 SCLAV_4555 M peptidase COG0739 Cluster_159369 V1020570 FADE25 map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I acyl-Coa dehydrogenase COG1960 Cluster_517241 V1020571 CTAF C Part of cytochrome c oxidase, its function is 11R1D Cluster_816048 V1020572 RPSU map03010 J 30S ribosomal protein S21 122SW Cluster_268128 V1020573 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_371631 V1020574 CYDC map02010 P ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC COG1132 Cluster_337795 V1020575 DUSB J Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_673127 V1020576 SECE map03060,map03070 U Preprotein translocase SecE subunit COG0690 Cluster_664518 V1020577 BL00143 L Transposase 122W1 Cluster_378472 V1020578 DCK map00230,map00240,map01100 F deoxynucleoside kinase COG1428 Cluster_254996 V1020580 MUTY map03410 L a g-specific adenine glycosylase COG1194 Cluster_530982 V1020581 MRAZ S Cell division protein mraZ COG2001 Cluster_176825 V1020588 P Phosphate-Selective Porin O and P 0ZV9B Cluster_152734 V1020590 S Inherit from NOG: (LipO)protein 103B0 Cluster_466705 V1020592 S Ser Thr phosphatase family protein COG1408 Cluster_292368 V1020593 HYPB K, O Hydrogenase accessory protein HypB COG0378 Cluster_479819 V1020594 O AhpC TSA family COG0526 Cluster_406705 V1020595 PNCA map00760,map01100 Q nicotinamidase COG1335 Cluster_153498 V1020596 EAPA map00565,map01100,map04146 C FAD linked oxidase domain protein COG0277 Cluster_551257 V1020599 S Domain of unknown function (DUF3127) 126YQ Cluster_188870 V1020600 K Transcriptional regulator 0XPSK Cluster_551874 V1205802 S NA 0ZHU9 Cluster_785126 V1205804 S NA 0ZHU9 Cluster_800744 V1205829 S NA 0ZHU9 Cluster_718142 V1205879 S NA 0ZHU9 Cluster_904744 V1205919 S NA 0ZHU9 Cluster_687471 V1205924 S NA 0ZHU9 Cluster_699123 V1205935 S NA 0ZHU9 Cluster_592573 V1205940 S NA 0ZHU9 Cluster_640872 V1205973 S NA 0ZHU9 Cluster_494578 V1205975 S NA 0ZHU9 Cluster_796872 V1205994 S NA 0ZHU9 Cluster_614043 V1206034 S NA 0ZHU9 Cluster_754873 V1206079 S NA 0ZHU9 Cluster_718145 V1206091 S NA 0ZHU9 Cluster_526043 V1206114 M NA 0YESU Cluster_528808 V1206128 GLVC map00010,map02060 G PTS System COG1264 Cluster_921279 V1206164 S NA 0ZHU9 Cluster_734617 V1206215 S NA 0ZHU9 Cluster_648796 V1206224 S NA 0ZHU9 Cluster_683080 V1206245 S NA 0ZHU9 Cluster_925272 V1206256 S NA 0ZHU9 Cluster_777269 V1206274 S NA 0ZHU9 Cluster_766113 V1206323 S NA 0ZHU9 Cluster_789124 V1206325 S NA 0ZHU9 Cluster_769888 V1206350 S NA 185WP@proNOG Cluster_836027 V1206369 S NA 0ZHU9 Cluster_632802 V1206407 YAGE E amino acid COG0531 Cluster_636839 V1206418 S NA 0ZHU9 Cluster_669704 V1206470 S NA 0ZHU9 Cluster_792904 V1206496 S NA 0ZHU9 Cluster_147279 V1206511 ECSB U (ABC) transporter COG4473 Cluster_336565 V1206513 S NA 0XV6C Cluster_200881 V1206514 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_828422 V1206515 S Filamentation induced by cAMP protein fic COG3177 Cluster_687478 V1206517 CORA P transporter COG0598 Cluster_438965 V1206519 PYRR map00240,map01100 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) COG2065 Cluster_57020 V1206528 GLPQ map00564 C glycerophosphoryl diester phosphodiesterase COG4781 Cluster_103420 V1206538 M NA 0YESU Cluster_585910 V1206553 S NA 0ZHU9 Cluster_762143 V1206562 S NA 0ZHU9 Cluster_603128 V1206572 S NA 0ZHU9 Cluster_785132 V1206579 K transcriptional regulator MERR family 1248T Cluster_847867 V1206580 S Membrane 11TU2 Cluster_644739 V1206586 S NA 0ZHU9 Cluster_632806 V1206628 S NA 0ZHU9 Cluster_327582 V1206635 S NA 11GVV Cluster_863736 V1206658 S NA 0ZHU9 Cluster_816804 V1206693 S NA 0ZHU9 Cluster_385851 V1206701 GND map00030,map00480,map01100,map01110,map01120 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) COG0362 Cluster_632807 V1206706 S NA 0ZHU9 Cluster_512427 V1206707 S NA 0ZHU9 Cluster_606743 V1206711 S NA 0ZHU9 Cluster_614046 V1206766 S NA 0ZHU9 Cluster_867776 V1206843 S NA 0ZHU9 Cluster_489600 V1206845 LCTP C L-lactate COG1620 Cluster_494579 V1206849 L Topoisomerase COG0550 Cluster_887921 V1206904 S NA 0ZHU9 Cluster_579472 V1206988 S NA 0ZHU9 Cluster_596050 V1207012 M Cell wall binding repeat 2-containing protein COG2247 Cluster_721463 V1207042 S NA 0ZHU9 Cluster_780980 V1207047 S NA 0ZHU9 Cluster_632808 V1207069 TRXA O Thioredoxin COG0526 Cluster_777277 V1207144 AMET_0417 S Phage head morphogenesis protein COG2369 Cluster_102248 V1207148 HSDS V restriction modification system DNA specificity domain COG0732 Cluster_160370 V1207149 THETH_0161 L Transposase COG3328 Cluster_557649 V1207150 RPSH map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) COG0096 Cluster_173708 V1207151 DINB L Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) COG0389 Cluster_832124 V1207156 RIBU S Membrane COG3601 Cluster_313736 V1207157 BH0311 L Transposase COG3328 Cluster_674079 V1207158 S NA 0ZHU9 Cluster_528809 V1207163 S NA 0ZHU9 Cluster_82538 V1207166 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_585911 V1207167 S Protein of unknown function (DUF1304) 0XV9E Cluster_582718 V1207168 S NA 0ZHU9 Cluster_614048 V1207171 S NA 0ZHU9 Cluster_268383 V1207174 S NA 11GVV Cluster_309277 V1207177 MNOD_0308 L Transposase COG3666 Cluster_828429 V1207179 DKGA1 C reductase COG0656 Cluster_428971 V1207185 WECD map00350,map00362,map00627,map00642,map00903,map01120 S -acetyltransferase 11PF0 Cluster_253990 V1207193 SDAA map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase COG1760 Cluster_121386 V1207195 map02010 G ABC transporter COG1653 Cluster_494580 V1207196 S NA 0ZHU9 Cluster_665395 V1207216 S NA 0ZHU9 Cluster_313737 V1207235 STP T phosphatase COG0631 Cluster_113499 V1207252 CELB map02060 G iic component COG1455 Cluster_548964 V1207255 S NA 0ZHU9 Cluster_566857 V1207259 BMUR_1332 S Domain of Unknown Function (DUF1599) 0XXR0 Cluster_159540 V1207310 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_589204 V1207311 S NA 0ZHU9 Cluster_182077 V1207325 M Cell surface protein 11GRZ Cluster_509848 V1207366 S NA 0ZHU9 Cluster_648801 V1207385 S NA 0ZHU9 Cluster_879814 V1207394 S NA 0ZHU9 Cluster_560720 V1207409 S NA 0ZHU9 Cluster_272372 V1207411 PGM map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_273702 V1207412 S NA 11GVV Cluster_917429 V1207417 PACA map00120,map00121,map01100 M Choloylglycine hydrolase COG3049 Cluster_450963 V1207460 S NA 0ZHU9 Cluster_327583 V1207469 ECSA V abc transporter atp-binding protein COG1131 Cluster_446968 V1207470 S NA 0ZHU9 Cluster_805006 V1207534 S NA 0ZHU9 Cluster_632812 V1207574 S NA 0ZHU9 Cluster_345737 V1207580 S NA 0ZHU9 Cluster_816810 V1207611 S NA 0ZHU9 Cluster_836041 V1207624 S NA 0ZHU9 Cluster_702220 V1207669 S NA 0YXBD Cluster_442952 V1207688 S NA 0ZHU9 Cluster_674082 V1207689 S NA 0ZHU9 Cluster_412486 V1207741 S NA 0ZHU9 Cluster_792920 V1207745 S NA 0ZHU9 Cluster_711510 V1207754 S NA 0ZHU9 Cluster_430947 V1207778 map00363,map00960,map01120 I esterase COG0657 Cluster_350216 V1020603 VICR map02020 T response regulator COG0745 Cluster_424780 V1020604 G transporter major facilitator family protein 0XRD8 Cluster_572442 V1020605 S NA 11VA3 Cluster_348646 V1020606 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_426664 V1020607 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_291044 V1020612 map02010 P Cobalt transport protein COG0619 Cluster_68819 V1020614 MEND map00130,map01100,map01110 H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) COG1165 Cluster_673129 V1020615 T Histidine kinase COG4585 Cluster_337796 V1020616 SSCG_03030 map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_509296 V1020617 S Transporter Permease Protein 0ZURF Cluster_373252 V1020620 UPP map00240,map01100 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) COG0035 Cluster_356749 V1020621 S Inherit from COG: esterase COG2819 Cluster_155966 V1020622 RLUA J Pseudouridine synthase COG0564 Cluster_301957 V1020624 YYCO S Orthopoxvirus protein of unknown function (DUF830) COG3863 Cluster_185399 V1020626 GCVT map00260,map00670,map00910,map01100 E The glycine cleavage system catalyzes the degradation of glycine (By similarity) COG0404 Cluster_115428 V1020628 CYCA E amino acid COG1113 Cluster_479820 V1020629 USPR K MarR family Transcriptional regulator 12AHX Cluster_421147 V1020633 JAG S Single-stranded nucleic acid binding R3H domain-containing protein COG1847 Cluster_295159 V1020634 SP_1245 S hydrolase COG0561 Cluster_562960 V1020635 YIDB S Bacterial protein of unknown function (DUF937) COG3753 Cluster_456480 V1020637 S phage protein 0XQDU Cluster_315018 V1020639 S Short-chain dehydrogenase reductase sdr COG0300 Cluster_519822 V1020640 S Membrane 12424 Cluster_530983 V1020642 S Protein of unknown function (DUF3021) 0YSIW Cluster_444552 V1020643 HSLV O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) COG5405 Cluster_358439 V1020645 CMK map00240,map00410,map00770,map01100,map01110 F Cytidine monophosphate kinase COG0283 Cluster_88040 V1020646 MQO3 map00620 C malate dehydrogenase (quinone) COG0579 Cluster_300548 V1020647 map02010 P cobalt transport COG0619 Cluster_129477 V1020651 S NA 11JA1 Cluster_569250 V1020654 S NA 124XV Cluster_624490 V1020655 PPNK map00760,map01100 G Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) COG0061 Cluster_148697 V1020656 L Integrase 0YTFQ Cluster_70486 V1020657 PRIA map03440 L Primosomal protein n' COG1198 Cluster_430571 V1020659 DEF J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) COG0242 Cluster_545236 V1020660 L Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) COG0816 Cluster_473118 V1020661 S sporulation and cell division repeat protein 11VBB Cluster_772715 V1020662 S NA 11XBE Cluster_415800 V1020663 map00350,map00362,map00627,map00642,map00903,map01120 S -acetyltransferase 11TPW Cluster_110594 V1020664 TNAA map00380 E tryptophanase EC 4.1.99.1 COG3033 Cluster_404970 V1020665 RIBE map00740,map01100 H riboflavin synthase, subunit alpha COG0307 Cluster_150298 V1020666 S NA 0YZKI Cluster_392599 V1020668 RECR map03440 L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) COG0353 Cluster_673130 V1020669 YBAB S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) COG0718 Cluster_161068 V1020670 HIPO map00360 E amidohydrolase COG1473 Cluster_588475 V1020671 PAND map00410,map00770,map01100,map01110 H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) COG0853 Cluster_264079 V1020672 PANC map00410,map00770,map01100,map01110 H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) COG0414 Cluster_175179 V1020673 S Archaeal ATPase COG1672 Cluster_144821 V1020674 PMT M glycosyl transferase, family 39 COG1928 Cluster_581976 V1020675 RSMI G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 Cluster_656167 V1020676 S NA 0Y25P Cluster_126664 V1020677 S NA 0XQBQ Cluster_76706 V1020684 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_358440 V1020687 CINA H competence damage-inducible protein COG1546 Cluster_361652 V1020688 PGSA map00564,map01100 I cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase COG0558 Cluster_533758 V1020690 DPS P Ferritin, Dps family protein COG0783 Cluster_436499 V1020691 MURQ map00520 G Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate COG2103 Cluster_196793 V1020692 YLEB S Outer surface protein COG3589 Cluster_346970 V1020695 S SNARE associated Golgi protein 0YNB0 Cluster_368315 V1020696 K Transcriptional regulator 12BGJ Cluster_178485 V1020697 M Sortase family COG3764 Cluster_152735 V1020700 TPAU_0274 L transposase COG3547 Cluster_682170 V1020701 S Addiction module antitoxin, RelB DinJ family 0XUTM Cluster_289766 V1020702 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_111301 V1020704 S NA 0YRUB Cluster_522524 V1020705 YBBP S TIGR00159 family COG1624 Cluster_201684 V1020706 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_237054 V1020707 S NA 0ZZWZ Cluster_221782 V1020708 YPDE map00500,map01100 E Peptidase m42 family protein COG1363 Cluster_330208 V1020709 E N-formylglutamate amidohydrolase 16XWF@proNOG Cluster_536669 V1020710 V Inherit from COG: Type II restriction enzyme, methylase COG1002 Cluster_134121 V1020711 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_149442 V1020714 SDAAA map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase COG1760 Cluster_227537 V1020715 S NA 0XTEF Cluster_157645 V1020716 YCHF J gtp-binding protein COG0012 Cluster_343818 V1020717 GLPF G Major Intrinsic Protein COG0580 Cluster_434459 V1020721 K RNA polymerase sigma-70 factor COG1595 Cluster_458404 V1020724 RIMM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) 11M4J Cluster_353441 V1020726 HMUY S NA 0XZUM Cluster_266739 V1020727 S NA 121T2 Cluster_509297 V1020730 S NA 11EPM Cluster_361653 V1020731 S NA 11EKM Cluster_486777 V1020733 FTN map00860 P ferritin COG1528 Cluster_210289 V1020735 LVIS_1721 L transposase COG2826 Cluster_417560 V1020736 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_464685 V1020737 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_479821 V1020738 MT3093 E amino acid-binding act 0ZHQE Cluster_740679 V1020739 GATC map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0721 Cluster_266740 V1020740 AGUB map00330,map01100 S hydrolase, carbon-nitrogen family COG0388 Cluster_295160 V1020741 FDHD C Necessary for formate dehydrogenase activity (By similarity) COG1526 Cluster_293745 V1020742 map00770,map01100 H Pantothenate kinase 109YT Cluster_178486 V1020743 SRTA M (sortase) family COG3764 Cluster_222942 V1020748 S Endonuclease Exonuclease phosphatase 0ZJ9Y Cluster_701607 V1020749 BCAV_3206 map05152 S Proteins of 100 residues with WXG COG4842 Cluster_695138 V1020750 S Protein of unknown function (DUF2580) COG4842 Cluster_94083 V1020752 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_381953 V1020757 GLGB map00500,map01100,map01110 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) COG0296 Cluster_514522 V1020758 S NA 0YIA5 Cluster_239635 V1020759 RSGA G May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) COG1162 Cluster_325726 V1020760 S NA 0XQBQ Cluster_293746 V1020761 CLOLE_0796 L recT protein COG3723 Cluster_413988 V1020762 map00363,map00960,map01120 I alpha beta hydrolase fold-3 domain protein COG0657 Cluster_272112 V1020763 YXKD S Uncharacterized protein conserved in bacteria (DUF2179) COG1284 Cluster_238353 V1020764 PANE map00770,map01100,map01110 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) COG1893 Cluster_75718 V1020768 S NA 0YDM2 Cluster_598852 V1020772 S HlyD-family transporter 0XPDT Cluster_146370 V1020773 map02010 V ABC transporter, ATP-binding protein COG1132 Cluster_144088 V1020776 P Receptor COG4771 Cluster_135734 V1020779 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_238354 V1020783 ARGF map00330,map01100,map01110,map01230 E ornithine carbamoyltransferase COG0078 Cluster_509298 V1020784 NRDI F Probably involved in ribonucleotide reductase function (By similarity) COG1780 Cluster_202717 V1020787 YKGB map00030,map01100,map01110,map01120 G 6-phosphogluconolactonase (EC 3.1.1.31) COG2706 Cluster_489066 V1020788 YWDH map00010,map00040,map00053,map00071,map00280,map00281,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00626,map00640,map00903,map01100,map01110,map01120 C Aldehyde dehydrogenase COG1012 Cluster_916683 V1020794 RPSJ map03010 J Involved in the binding of tRNA to the ribosomes (By similarity) COG0051 Cluster_397950 V1020795 RPLC map03010 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 Cluster_394341 V1020796 RPLD map03010 J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) COG0088 Cluster_924543 V1020798 PANE map00770,map01100,map01110 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) COG1893 Cluster_408457 V1020800 S NA 11EM0 Cluster_448994 V1207819 MDLA map02010 V ABC transporter transmembrane region COG1132 Cluster_847881 V1207825 S NA 0ZHU9 Cluster_724816 V1207827 S NA 0ZHU9 Cluster_705290 V1207833 S NA 0ZHU9 Cluster_711512 V1207846 S NA 0ZHU9 Cluster_678542 V1207888 S NA 0ZHU9 Cluster_796891 V1207909 S NA 0ZHU9 Cluster_507261 V1207972 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_507262 V1207973 S NA 0ZHU9 Cluster_614051 V1208010 S NA 0ZHU9 Cluster_734631 V1208041 S NA 0ZHU9 Cluster_796894 V1208047 S NA 0ZHU9 Cluster_548966 V1208075 map04112 M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) COG1589 Cluster_551877 V1208084 J TRAM domain COG2265 Cluster_554722 V1208090 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_557652 V1208107 CBPC M choline binding protein COG5263 Cluster_851653 V1208113 S NA 0ZHU9 Cluster_560725 V1208114 HPK31 T Histidine kinase COG0642 Cluster_762166 V1208115 S NA 0ZHU9 Cluster_669715 V1208122 S NA 0ZHU9 Cluster_678547 V1208159 S NA 185WP@proNOG Cluster_917439 V1208176 S NA 0ZHU9 Cluster_603135 V1208213 L Topoisomerase COG0550 Cluster_744662 V1208224 S NA 0ZHU9 Cluster_606748 V1208227 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_636847 V1208261 S NA 17D58@proNOG Cluster_871710 V1208272 S NA 0ZHU9 Cluster_859396 V1208336 S NA 0ZHU9 Cluster_344105 V1208359 S NA 11GVV Cluster_436921 V1208361 HIPMA_0065 L Transposase COG3328 Cluster_796896 V1208363 S NA 0ZHU9 Cluster_55241 V1208364 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_275052 V1208365 S NA 11GVV Cluster_75787 V1208368 map00020,map00190,map00623,map00650,map00720,map00984,map01100,map01110,map01120,map02020 C Flavocytochrome c COG1053 Cluster_560726 V1208369 GLNL map02020 T response regulator COG0784 Cluster_748022 V1208371 YAAA L UPF0246 protein COG3022 Cluster_512429 V1208376 OXLT G Major Facilitator 0XQUK Cluster_520351 V1208381 S NA 0ZHU9 Cluster_502293 V1208383 T Universal stress protein COG0589 Cluster_579476 V1208386 S NA 0ZHU9 Cluster_142765 V1208397 S NA COG4990 Cluster_360409 V1208413 K Sucrose operon repressor COG1609 Cluster_361979 V1208414 GLPT G transporter 0XPWC Cluster_477918 V1208425 TPX O Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) COG2077 Cluster_813022 V1208430 S Protein of unknown function (DUF3042) 0ZR85 Cluster_398267 V1208440 YHCG V abc transporter atp-binding protein COG1131 Cluster_632818 V1208442 S NA 0ZHU9 Cluster_157811 V1208451 Y0402 S enhancing factor (Viral) 0XNVM Cluster_160371 V1208456 GND map00030,map00480,map01100,map01110,map01120 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) COG0362 Cluster_573162 V1208474 S NA 0ZHU9 Cluster_596055 V1208481 S NA 0ZHU9 Cluster_847889 V1208493 S NA 0ZHU9 Cluster_315323 V1208495 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase ii COG0046 Cluster_467182 V1208496 RNHB map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0164 Cluster_432955 V1208497 YLQF K Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) COG1161 Cluster_454941 V1208501 S NA 0ZHU9 Cluster_266980 V1208504 LIPL H Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) COG0095 Cluster_448995 V1208511 YIFK E amino acid COG1113 Cluster_217326 V1208517 GTFA map00500 G Sucrose phosphorylase COG0366 Cluster_656997 V1208518 TRXA O Thioredoxin COG0526 Cluster_357073 V1208523 HELD map03420,map03430 L helicase COG3973 Cluster_425146 V1208526 LYTR K TRANSCRIPTIONal COG1316 Cluster_269731 V1208531 PIPD E Dipeptidase COG4690 Cluster_239876 V1208539 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_350548 V1208544 NPDA map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_781007 V1208552 S NA 0ZHU9 Cluster_368610 V1208559 TERC P membrane protein, TerC COG0861 Cluster_714904 V1208579 COF S Hydrolase COG0561 Cluster_728090 V1208585 S NA 0ZHU9 Cluster_921330 V1208588 GLYA map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01230 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) COG0112 Cluster_545910 V1208590 map02020 V ABC transporter, permease COG0577 Cluster_335031 V1208593 S protease 0XW1D Cluster_332042 V1208599 YFDH map00051,map00510,map01100 M Glycosyl Transferase COG0463 Cluster_291284 V1208601 ERIC P Chloride channel COG0038 Cluster_302214 V1208607 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0516 Cluster_484970 V1208631 G Major Facilitator COG2814 Cluster_316848 V1208635 SUA J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0009 Cluster_333530 V1208657 ADHA map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120 C alcohol dehydrogenase COG1064 Cluster_335032 V1208663 RFAB map00540,map01100 M Glycosyl transferase (Group 1 COG0438 Cluster_460893 V1208664 S NA 123K0 Cluster_777290 V1208665 S NA 129UJ Cluster_338105 V1208669 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_338106 V1208674 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_340993 V1208677 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_674089 V1208679 YDEP K Transcriptional regulator COG1733 Cluster_625289 V1208680 FOLB map00790,map01100 H dihydroneopterin aldolase COG1539 Cluster_669716 V1208682 S NA 0ZHU9 Cluster_344107 V1208685 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_480336 V1208688 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_718160 V1208693 SEPF S Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) COG1799 Cluster_380540 V1208698 HADH map00360,map00362,map00650,map01100,map01120 C Dehydrogenase COG1250 Cluster_366992 V1208701 PEPX E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) 0XPUZ Cluster_357074 V1208705 TETP T Tetracycline resistance protein COG0480 Cluster_360410 V1208707 PEPX E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) 0XPUZ Cluster_610422 V1208712 YAAK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) COG0718 Cluster_492098 V1208713 NQR map00051,map00363,map00591,map00625,map00650,map01100,map01120 S Nadph-dependent fmn reductase COG0431 Cluster_805017 V1208715 S NA 17D58@proNOG Cluster_365288 V1208716 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_520352 V1208723 ANSA map00250,map00460,map00910,map01100,map01110 E L-asparaginase COG0252 Cluster_773560 V1208725 K Sucrose operon repressor COG1609 Cluster_389403 V1208729 FABG3 map00140,map01100 S Short-chain dehydrogenase reductase sdr COG1028 Cluster_371942 V1208731 LMRB P Lincomycin resistance protein LmrB 0XNN3 Cluster_531600 V1208734 SDS map00900,map01110 H synthase COG0142 Cluster_378818 V1208739 PSTS map02010,map02020,map05152 P phosphate COG0226 Cluster_380541 V1208741 S Inherit from NOG: domain protein 0XP4A Cluster_839900 V1208743 S NA 0ZHU9 Cluster_507263 V1208745 S NA 0ZHU9 Cluster_454942 V1208749 S Uncharacterized protein conserved in bacteria (DUF2252) COG4320 Cluster_625290 V1208751 S NA 0ZHU9 Cluster_475716 V1208752 PIPD E Dipeptidase COG4690 Cluster_385853 V1208754 CYDD map02010 V ABC, transporter COG4988 Cluster_387699 V1208759 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_394753 V1208770 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_497091 V1208781 YJDF S NA 11P5R Cluster_401774 V1208783 PTSI map00051,map01100,map02060 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) COG1080 Cluster_403555 V1208784 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_403556 V1208785 PLSX map00561,map00564,map01100 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) COG0416 Cluster_405362 V1208786 S Rib/alpha-like repeat 0YK85 Cluster_460894 V1208790 YECS map02010 E amino acid ABC transporter COG0765 Cluster_718161 V1208799 S NA 0ZHU9 Cluster_526050 V1208803 YIBE S YibE F family protein COG5438 Cluster_460895 V1208807 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_430948 V1208813 DPRA L DNA protecting protein DprA COG0758 Cluster_458845 V1208825 NRDF map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_463015 V1208829 YJCE P Na H antiporter COG0025 Cluster_731395 V1208834 ACYP map00620,map00627,map01120 C Acylphosphatase COG1254 Cluster_419704 V1208837 LMRB G Major Facilitator Superfamily 0XNN3 Cluster_492099 V1208838 MACB map02010 V Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) COG1136 Cluster_421503 V1208840 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (alpha subunit) COG0587 Cluster_421504 V1208845 PHND map02010 P phosphonate ABC transporter, periplasmic phosphonate-binding protein COG3221 Cluster_421505 V1208846 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_728094 V1208848 HELD map03420,map03430 L helicase COG3973 Cluster_425147 V1208852 G Major Facilitator COG0477 Cluster_563668 V1208860 YNER S HesB YadR YfhF-family protein COG4841 Cluster_475717 V1208862 YKOD map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_596057 V1208863 S NA 0ZHU9 Cluster_748025 V1208865 S NA 0ZHU9 Cluster_606749 V1208868 RSFS S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) COG0799 Cluster_792930 V1208869 YKHA map00903,map01040 I thioesterase Superfamily protein COG1607 Cluster_432956 V1208877 GLSA map00250,map00330,map00471,map00910,map01100,map01120,map04724,map04727,map04964 E Glutaminase COG2066 Cluster_545912 V1208888 ISPA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_896180 V1208889 RRMJ J Hemolysin A COG1189 Cluster_748026 V1208890 PGSA map00564,map01100 I cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase COG0558 Cluster_434878 V1208891 KINE T sensor protein 0XNMH Cluster_748027 V1208897 E, G EamA-like transporter family COG0697 Cluster_748028 V1208898 HELD map03420,map03430 L helicase COG3973 Cluster_436923 V1208899 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_599575 V1208902 SP_0889 S Death-On-Curing Family COG3654 Cluster_569949 V1208907 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_442953 V1208909 DNAB L replication initiation and membrane attachment protein COG3611 Cluster_442954 V1208912 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_442955 V1208914 YHAN S domain protein COG4717 Cluster_444935 V1208918 E amino acid COG0531 Cluster_444936 V1208920 UVRA map03420 L excinuclease COG0178 Cluster_446969 V1208922 RARA L recombination factor protein RarA COG2256 Cluster_471465 V1208935 NAPA2 P Na H antiporter COG0569 Cluster_450965 V1208937 NAPA P Sodium hydrogen exchanger COG0475 Cluster_452917 V1208941 GLNK map02020 T Histidine kinase COG0642 Cluster_454943 V1208942 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG2812 Cluster_644749 V1208947 YEAL S UPF0756 membrane protein COG2707 Cluster_458846 V1208950 GALA map00052,map00561,map00600,map00603 G alpha-galactosidase COG3345 Cluster_458847 V1208953 ARGH map00250,map00330,map01100,map01110,map01230 E arginosuccinase COG0165 Cluster_523122 V1208954 HELD map03420,map03430 L helicase COG3973 Cluster_460898 V1208958 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_463016 V1208961 YXIO G major facilitator superfamily COG2270 Cluster_648806 V1208962 S NA 0ZHU9 Cluster_463017 V1208965 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_465100 V1208967 S Uncharacterised protein family (UPF0104) COG0392 Cluster_734637 V1208968 S NA 0XQ6D Cluster_465101 V1208969 YICL E, G Transporter COG0697 Cluster_465102 V1208970 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_465103 V1208971 ECSB U (ABC) transporter COG4473 Cluster_467183 V1208976 MURF map00300,map00550,map01100 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) COG0770 Cluster_467184 V1208977 P Cadmium resistance transporter 0YIQW Cluster_497092 V1208979 SOJ D Chromosome Partitioning Protein COG1192 Cluster_471466 V1208985 PIPD E Dipeptidase COG4690 Cluster_636849 V1208990 SCRR K Sucrose operon repressor COG1609 Cluster_509850 V1208995 GPSA map00564 C NADPH-dependent glycerol-3-phosphate dehydrogenase COG0240 Cluster_475718 V1209002 MUTS2 map03430 L muts2 protein COG1193 Cluster_475719 V1209003 COMFA L Competence protein COG4098 Cluster_475720 V1209004 GAT map00230,map00983,map01100 F Glutamine amido-transferase COG0518 Cluster_576384 V1209007 WANG_1499 S Transposase 11N3I Cluster_477920 V1209008 LACZ map00052,map00511,map00600,map01100 G beta-galactosidase COG3250 Cluster_557653 V1209013 DING L helicase COG1199 Cluster_632820 V1209022 ASP1 S accessory Sec system protein Asp1 11JCE Cluster_741377 V1209024 VEG S Veg protein COG4466 Cluster_482646 V1209032 YVOA K (GntR family) (Transcriptional regulator COG2188 Cluster_482647 V1209034 YKII S NA 11GTZ Cluster_484971 V1209035 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_625292 V1209043 LYTS map02020 T Histidine kinase COG3275 Cluster_489601 V1209050 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_629003 V1209053 P drug resistance transporter, EmrB QacA subfamily 0XQZX Cluster_520353 V1209054 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_781010 V1209055 RPOZ map00230,map00240,map01100,map03020 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) COG1758 Cluster_762175 V1209059 RMAH K Transcriptional regulator 0XUB6 Cluster_867800 V1209060 CRCB2 D Protein CrcB homolog COG0239 Cluster_644750 V1209061 S Protein CrcB homolog 0XUV1 Cluster_526051 V1209063 K TRANSCRIPTIONAl REGULATOR GntR family COG2186 Cluster_554727 V1209066 S NA 0ZCWV Cluster_847895 V1209067 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_497093 V1209070 PATB map00270,map00450,map00920,map01100,map01110,map01230 E Aminotransferase class I and II COG1168 Cluster_843981 V1209072 NYLA map00330,map00360,map00380,map00627,map00643,map01120 J amidase (EC COG0154 Cluster_734638 V1209073 LYC M glycoside hydrolase, family 25 11T0J Cluster_836061 V1209076 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_499747 V1209077 ECFA2 map02010 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates COG1122 Cluster_531602 V1209078 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_499748 V1209081 NTPJ P Potassium uptake protein COG0168 Cluster_502294 V1209084 YLBL T domain protein COG3480 Cluster_537284 V1209087 S NA 0Z167 Cluster_502295 V1209088 LDH map00010,map00270,map00620,map00640,map01100,map01110,map01120 C L-lactate dehydrogenase COG0039 Cluster_809059 V1209089 S NA 0ZHU9 Cluster_507264 V1209091 ADDB L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination COG3857 Cluster_507265 V1209094 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_507266 V1209095 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_507267 V1209098 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_507268 V1209099 T EAL domain 11X2Y Cluster_507269 V1209100 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_824615 V1209104 ARLR map02020 T response regulator COG0745 Cluster_509851 V1209105 NSS S galactofuranosyltransferase 11KQ1 Cluster_563669 V1209112 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_515133 V1209123 LSA S (ABC) transporter COG0488 Cluster_515134 V1209128 S NA 11GVV Cluster_711517 V1209132 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_517811 V1209135 MREC M Involved in formation and maintenance of cell shape (By similarity) COG1792 Cluster_523123 V1209144 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_523124 V1209146 SP_1529 M Polysaccharide Biosynthesis Protein COG2244 Cluster_520356 V1209149 PNCA map00760,map01100 Q isochorismatase COG1335 Cluster_589211 V1209156 MSRA O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) COG0225 Cluster_526052 V1209159 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_528811 V1209166 LMRB P Lincomycin resistance protein LmrB 0XNN3 Cluster_526054 V1209168 G Major Facilitator 0XPHU Cluster_528812 V1209169 DING map00230,map00240,map01100,map03030,map03430,map03440 L helicase COG1199 Cluster_531603 V1209178 RLMB map00340,map00350,map00624,map01120 J RNA methyltransferase TrmH family group 3 COG0566 Cluster_661232 V1209188 MURE map00300,map00550 M mur ligase COG0769 Cluster_531604 V1209190 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_531605 V1209191 LPLA map00785,map01100 H Lipoate-protein, ligase COG0095 Cluster_545914 V1209192 RNJB map03018 O Metallo-Beta-Lactamase COG0595 Cluster_531606 V1209193 ARAB map00040,map01100 G Carbohydrate kinase COG1070 Cluster_537285 V1209200 PRFC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) COG4108 Cluster_537286 V1209205 EST I Carboxylesterase (EC 3.1.1.1) COG1647 Cluster_537287 V1209208 S Frg domain protein 0ZXCB Cluster_661233 V1209211 S NA 0Z8F5 Cluster_540093 V1209212 map03440 K Divergent AAA domain protein COG2865 Cluster_540094 V1209214 AZLC E azlc family COG1296 Cluster_537288 V1209216 SUFC O feS assembly ATPase SufC COG0396 Cluster_754909 V1209220 L Transposase COG2826 Cluster_542963 V1209224 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_621499 V1209230 YBEY map00240,map00983,map01100 F Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) COG0319 Cluster_705294 V1209237 LTRA S low temperature requirement protein COG4292 Cluster_695862 V1209238 RARA L recombination factor protein RarA COG2256 Cluster_545915 V1209239 DCK map00230,map00240,map01100 F deoxynucleoside kinase COG1428 Cluster_542965 V1209240 I esterase COG0657 Cluster_714907 V1209242 YPMS S Uncharacterized protein conserved in bacteria (DUF2140) COG4698 Cluster_900443 V1209243 S UPF0346 protein COG4479 Cluster_661234 V1209245 AMSD map00051 M Glycosyltransferase COG0438 Cluster_545916 V1209252 G phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 COG2211 Cluster_548969 V1209253 MDLA map02010 V ABC transporter transmembrane region COG1132 Cluster_548970 V1209257 T Universal stress protein COG0589 Cluster_548971 V1209258 L helicase COG4889 Cluster_554729 V1209263 HADH map00360,map00362,map00650,map01100,map01120 C Dehydrogenase COG1250 Cluster_554731 V1209269 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_554732 V1209272 YIHY S ribonuclease BN COG1295 Cluster_554733 V1209273 COPA P p-type ATPase COG2217 Cluster_554734 V1209276 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_724829 V1209282 CADA P heavy metal translocating p-type ATPase COG2217 Cluster_721483 V1209288 ZURA map02010 P ABC transporter COG1121 Cluster_560727 V1209293 PARC L DNA topoisomerase IV, subunit A COG0188 Cluster_754910 V1209305 C trp repressor binding protein COG0716 Cluster_592582 V1209307 L adenine specific DNA methyltransferase COG4889 Cluster_579479 V1209309 RPLQ map03010 J 50S ribosomal protein l17 COG0203 Cluster_563671 V1209314 CYDC map02010 V (ABC) transporter COG4987 Cluster_728097 V1209324 L helicase domain protein COG4889 Cluster_566862 V1209328 MBL D Rod shape-determining protein mreb COG1077 Cluster_566863 V1209331 ICAA map00561,map01100 M Glycosyl transferase, family 2 COG1215 Cluster_569952 V1209339 COPA P p-type ATPase COG2217 Cluster_569953 V1209341 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_569954 V1209344 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_573165 V1209348 YFHO S Membrane COG4485 Cluster_573166 V1209351 S NA 120ST Cluster_573167 V1209352 PRKC T serine threonine protein kinase COG2815 Cluster_576387 V1209361 KDGR K Transcriptional regulator COG1609 Cluster_576389 V1209366 ARAT map04113 G transporter 0XNQK Cluster_714908 V1209371 S Nadph-dependent fmn reductase COG0431 Cluster_748032 V1209372 RNC map03008,map05205 K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) COG0571 Cluster_699139 V1209373 L DNA ligase COG0272 Cluster_816828 V1209375 GLNL map02020 T response regulator COG0784 Cluster_724830 V1209377 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_582722 V1209381 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_781013 V1209385 RIBU S Membrane COG3601 Cluster_582723 V1209386 FTSI map00550,map01100 M penicillin-binding protein COG0768 Cluster_632821 V1209387 I acidPPc COG0671 Cluster_805023 V1209392 FOLA map00670,map00790,map01100 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) COG0262 Cluster_585916 V1209393 GATA map00970,map01100 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) COG0154 Cluster_721484 V1209396 YBEC E amino acid COG0531 Cluster_585917 V1209401 STPC map02010 V ABC transporter COG1131 Cluster_606750 V1209406 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_596059 V1209410 SCLAV_3855 K MarR family Transcriptional regulator 121KI Cluster_665401 V1209411 J Inherit from COG: Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA (By similarity) COG3270 Cluster_589213 V1209416 map02010 V ABC transporter COG1131 Cluster_592585 V1209421 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) COG0706 Cluster_592587 V1209428 ADDA L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation COG1074 Cluster_855450 V1209432 THIM map00730,map01100 H 4-methyl-5-beta-hydroxyethylthiazole kinase COG2145 Cluster_596061 V1209437 ARAD map00040,map00053,map01100,map01120 G L-ribulose-5-phosphate 4-epimerase COG0235 Cluster_820607 V1209438 DNAG map03030 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 Cluster_599576 V1209439 THID map00730,map01100 H phosphomethylpyrimidine kinase COG0351 Cluster_596062 V1209440 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_714909 V1209442 RPSP map03010 J 30s ribosomal protein S16 COG0228 Cluster_599577 V1209443 S Inherit from NOG: domain protein 0XP4A Cluster_603136 V1209449 SUHB map00521,map00562,map01100,map01110,map04070 G inositol monophosphatase COG0483 Cluster_603137 V1209451 map00051 S biosynthesis protein 0XQI4 Cluster_603138 V1209453 MRAY map00550,map01100 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) COG0472 Cluster_606751 V1209457 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_603139 V1209460 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_741379 V1209462 map00051 S biosynthesis protein 0XQI4 Cluster_699140 V1209463 YKII S NA 11GTZ Cluster_606752 V1209465 YQEH S ribosome biogenesis GTPase YqeH COG1161 Cluster_610424 V1209466 DACA map00550,map01100 M carboxypeptidase COG1686 Cluster_640883 V1209469 RECG map03440 L ATP-dependent DNA helicase recG COG1200 Cluster_705296 V1209470 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_610426 V1209471 YFHO S Membrane COG4485 Cluster_610427 V1209474 KINE T sensor protein 0XNMH Cluster_614058 V1209477 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_617837 V1209493 G phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 COG2211 Cluster_617838 V1209494 RSGA G May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) COG1162 Cluster_617840 V1209496 ARCT map00300,map00480,map01100,map01120,map01230 E Dipeptidase COG0624 Cluster_824621 V1209497 S Small integral membrane protein (DUF2273) COG5547 Cluster_617841 V1209500 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_621501 V1209502 HELD map03420,map03430 L helicase COG3973 Cluster_847898 V1209507 RNMV L Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) COG1658 Cluster_781015 V1209509 RPSN map03010 J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) COG0199 Cluster_625293 V1209513 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0847 Cluster_629004 V1209515 F Hydroxymethylpyrimidine transporter CytX COG1457 Cluster_741381 V1209517 GTF1 M An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) COG0438 Cluster_629005 V1209518 YTXK L Adenine-specific COG0827 Cluster_816831 V1209521 YBAK S YbaK ebsC protein COG2606 Cluster_629006 V1209523 L adenine specific DNA methyltransferase COG4889 Cluster_629007 V1209524 MVAK2 map00900,map01100,map01110 I Phosphomevalonate kinase COG1577 Cluster_708415 V1209525 PEPC E aminopeptidase c COG3579 Cluster_724832 V1209529 YKFB M mandelate racemase muconate lactonizing COG4948 Cluster_636851 V1209535 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_828454 V1209536 BL02899 K Transcriptional regulator COG1476 Cluster_632822 V1209538 MURE map00300,map00550 M mur ligase COG0769 Cluster_678555 V1209539 LMRA map02010 V ABC transporter COG1132 Cluster_636852 V1209540 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_724833 V1209541 M ErfK YbiS YcfS YnhG COG1376 Cluster_773570 V1209545 PSAA map02010 P ABC transporter COG0803 Cluster_636853 V1209546 NUSA K Transcription elongation factor NusA COG0195 Cluster_636854 V1209547 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_640884 V1209548 NPR P pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_640885 V1209550 YDIF S Abc transporter COG0488 Cluster_751459 V1209558 TRMD map00900,map01100,map01110 J Specifically methylates guanosine-37 in various tRNAs (By similarity) COG0336 Cluster_734640 V1209559 YLBM S UPF0348 protein COG1323 Cluster_644752 V1209562 YFMR S ABC transporter, ATP-binding protein COG0488 Cluster_644753 V1209567 PRFA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) COG0216 Cluster_687495 V1209569 GTFA map00500 G Sucrose phosphorylase COG0366 Cluster_875829 V1209571 S NA 0ZHU9 Cluster_777294 V1209575 LMRA map02010 V ABC transporter COG1132 Cluster_648810 V1209576 PIPD E Dipeptidase COG4690 Cluster_705298 V1209577 AVTA map00300,map01100,map01210,map01230 K Transcriptional regulator, GntR family COG1167 Cluster_652877 V1209579 SUN map00340,map00350,map00624,map01120 J NOL1 NOP2 sun family protein COG3270 Cluster_652878 V1209581 DLTA map00473,map05150 H Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) COG1020 Cluster_652879 V1209583 AZLC E azlc family COG1296 Cluster_652880 V1209585 MTNN map00270,map01100 F Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) COG0775 Cluster_699141 V1209587 CUDT P Transporter COG1292 Cluster_792936 V1209588 CJAA map02010,map02020 E ABC transporter substrate-binding protein COG0834 Cluster_657003 V1209592 TRXB map00240,map00450 C ferredoxin--nadp reductase COG0492 Cluster_657004 V1209593 SECA2 map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_721485 V1209602 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_665403 V1209603 GNTK map00030,map01100,map01110,map01120 G Gluconate kinase COG1070 Cluster_766150 V1209608 SP_1786 S Toxin-antitoxin system, antitoxin component, HicB family COG1598 Cluster_687496 V1209609 T metallophosphoesterase COG0639 Cluster_665405 V1209610 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_665406 V1209611 S Membrane COG4485 Cluster_884020 V1209613 YABO J s4 domain protein COG1188 Cluster_714910 V1209616 YSNB S Phosphodiesterase, mj0936 family COG0622 Cluster_674093 V1209631 DUSB J Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_674094 V1209634 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (alpha subunit) COG0587 Cluster_678556 V1209636 PANE1 map00770,map01100,map01110 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) COG1893 Cluster_674095 V1209637 CCA map03013,map03018 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate COG0617 Cluster_813038 V1209640 ASNA map00250,map00460,map00910,map01100,map01110,map01230 E asparagine synthetase A COG2502 Cluster_683092 V1209649 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase ii COG0046 Cluster_683093 V1209650 S Protein of unknown function (DUF1002) COG4086 Cluster_687497 V1209652 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_10543 V1209666 S NA 12A0K Cluster_30352 V1209667 GBS0396 map03070 U Pfam:TraG COG3505 Cluster_284476 V1209673 SRTB M (sortase) family COG3764 Cluster_47866 V1209674 GLVC map00010,map02060 G PTS System COG1264 Cluster_98433 V1209675 GABD map00250,map00350,map00650,map01100,map01120 C Dehydrogenase COG1012 Cluster_25413 V1209677 S Lpxtg-motif cell wall anchor domain protein 0Y44U Cluster_7526 V1209678 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_512431 V1209683 S Thioredoxin 0ZB1G Cluster_89505 V1209688 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_436924 V1209689 WANG_1264 L Transposase COG2452 Cluster_396544 V1209691 K transcriptional regulator COG0583 Cluster_407053 V1209692 S Major tail protein 0Y77V Cluster_366993 V1209693 S phage major capsid protein, HK97 family 0XTEI Cluster_360411 V1209694 I PAP2 Family COG0671 Cluster_120617 V1209696 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_813040 V1209698 MURP map00500,map00520,map02060 G pts system COG2190 Cluster_48070 V1209699 BGLF map00010,map00500,map00520,map02060 G pts system COG2190 Cluster_107047 V1209700 S NA 11VH8 Cluster_223148 V1209701 IUNH2 map00230,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_279053 V1209702 CAS1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) COG1518 Cluster_221967 V1209703 N, U Competence protein COG2804 Cluster_264342 V1209704 S hydrolase COG4814 Cluster_384093 V1209705 THIJ S intracellular protease Pfpi family COG0693 Cluster_206118 V1209708 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_440936 V1209709 LGAS_0572 L Integrase COG0582 Cluster_492101 V1209711 S Methyltransferase 11P8X Cluster_25899 V1209712 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_419705 V1209713 SP_1246 S Hydrolase COG0561 Cluster_195296 V1209715 S Toprim domain protein 0XSQN Cluster_471467 V1209716 S NA 11GVV Cluster_216124 V1209718 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_18206 V1209719 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_384094 V1209720 MECA O Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis COG4862 Cluster_477921 V1209722 MT2607 map00330,map00480,map01100,map01110 E decarboxylase COG1982 Cluster_347307 V1209723 O Matrixin COG5549 Cluster_112761 V1209724 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_227755 V1209725 RGG K Transcriptional regulator COG1396 Cluster_198881 V1209726 YLEB S Outer surface protein COG3589 Cluster_303658 V1209727 T protein tyrosine serine phosphatase COG2365 Cluster_272373 V1209728 CITM C Citrate transporter COG2851 Cluster_348929 V1209729 RSUA J Pseudouridine synthase COG1187 Cluster_766151 V1209730 YBHL S Membrane COG0670 Cluster_537289 V1209731 map00350,map00360,map00362,map00621,map00622,map01100,map01120 Q hydratase decarboxylase COG3971 Cluster_452918 V1209732 YMDB S appr-1-p processing domain protein COG2110 Cluster_357075 V1209733 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_387700 V1209734 S tpr repeat-containing protein 11U03 Cluster_407054 V1209735 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_197890 V1209736 MALF map02010 P permease protein COG1175 Cluster_75162 V1209738 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 Cluster_545917 V1209740 SP_0742 S degv family COG1307 Cluster_322942 V1209741 RECO map03440 L Involved in DNA repair and RecF pathway recombination (By similarity) COG1381 Cluster_189878 V1209745 CARA map00240,map00250,map01100 F carbamoyl-phosphate synthetase glutamine chain COG0505 Cluster_265667 V1209747 RLUD2 J pseudouridine synthase COG0564 Cluster_64839 V1209748 MNOD_0308 L Transposase COG3666 Cluster_45168 V1209750 S NA 11NI8 Cluster_636855 V1209751 S NA 102VM Cluster_161200 V1209752 SBND G Major Facilitator 0ZVCH Cluster_636856 V1209754 DNAB L replication initiation and membrane attachment protein COG3611 Cluster_353716 V1209755 AACC V aminoglycoside N(3)-acetyltransferase COG2746 Cluster_324520 V1209756 YUFN S basic membrane COG1744 Cluster_60139 V1209758 YKCB M glycosyl transferase, family 39 COG1807 Cluster_430949 V1209762 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0847 Cluster_300817 V1209764 YDIF S ABC transporter, ATP-binding protein COG0488 Cluster_182078 V1209765 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_417933 V1209770 SCRR K Sucrose operon repressor COG1609 Cluster_606753 V1209772 YBBR S ybbr family COG4856 Cluster_366994 V1209773 C Nitroreductase COG0778 Cluster_298173 V1209776 PI346 L dna replication protein COG1484 Cluster_79786 V1209779 M Cell surface protein 11GRZ Cluster_107627 V1209782 WANG_0286 L Transposase COG2801 Cluster_744670 V1209783 XSEB map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1722 Cluster_360413 V1209784 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_322943 V1209785 YIBF S multi-transmembrane protein COG5438 Cluster_368611 V1209787 TCYC map02010 E ABC transporter, ATP-binding protein COG1126 Cluster_291285 V1209789 K anti-repressor COG3645 Cluster_509852 V1209790 S Hydrolase COG4814 Cluster_319894 V1209791 S NA 0XNUC Cluster_310715 V1209794 CSHB map03018 L ATP-dependent RNA helicase COG0513 Cluster_332043 V1209796 MURG map00550,map01100,map04112 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) COG0707 Cluster_399987 V1209798 RSMC J methyltransferase COG2813 Cluster_554735 V1209799 THIN map00730,map01100 H thiamine COG1564 Cluster_169282 V1020801 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_86306 V1020802 XYLB map00040,map01100 G xylulokinase COG1070 Cluster_306286 V1020803 FEPC map02010 P ABC, transporter COG1120 Cluster_361654 V1020804 LSPA map03060 U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) 11G1Y Cluster_581977 V1020805 DKSA S DnaK suppressor protein 11IHW Cluster_536670 V1020806 BMUL_1742 S signal peptide protein COG4731 Cluster_266741 V1020807 S degv family COG1307 Cluster_412067 V1020808 RARA L recombination factor protein RarA COG2256 Cluster_307653 V1020809 S NA 0YWA6 Cluster_164344 V1020810 DXR map00900,map01100,map01110 I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) COG0743 Cluster_77439 V1020811 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_202718 V1020812 ACEE map00010,map00020,map00620,map00650,map01100,map01110,map01120 C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) COG2609 Cluster_77749 V1020813 P tonB-dependent Receptor COG4771 Cluster_177628 V1020814 SCLAV_2537 J methyltransferase COG2890 Cluster_595258 V1020817 S NA 0ZHU9 Cluster_244922 V1020818 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_743920 V1020819 S NA 0ZHU9 Cluster_270816 V1020820 FTSI map00550,map01100 M penicillin-binding protein COG0768 Cluster_339281 V1020824 K hemerythrin hhe cation binding domain protein 11HP7 Cluster_264080 V1020827 SSGB E HAD-superfamily subfamily IB hydrolase COG0560 Cluster_239636 V1020829 S Pfam:DUF1812 0Y61M Cluster_272113 V1020830 GLUD map02010 E amino acid AbC transporter COG0765 Cluster_572444 V1020833 RPSK map03010 J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) COG0100 Cluster_572445 V1020834 ANSA map00250,map00460,map00910,map01100,map01110 E L-asparaginase COG0252 Cluster_239637 V1020835 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Ribose-phosphate pyrophosphokinase COG0462 Cluster_428586 V1020836 TRPG map00230,map00400,map00983,map01100,map01110,map01230 E anthranilate synthase COG0512 Cluster_647917 V1020837 RLUC2 J pseudouridine synthase COG0564 Cluster_256226 V1020838 USPA1 T Universal stress protein COG0589 Cluster_79092 V1020839 SPEB S peptidase C10 11SDT Cluster_356750 V1020840 UREF O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) COG0830 Cluster_333239 V1020841 METI map02010 P ABC transporter, permease COG2011 Cluster_403185 V1020842 METN map02010 P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COG1135 Cluster_862952 V1020843 S NA 0ZHU9 Cluster_300549 V1020847 M NA 0ZYVM Cluster_188871 V1020848 S Terminase large subunit COG4626 Cluster_285631 V1020850 K Transcriptional regulator, ARAC family 125DJ Cluster_368316 V1020851 DNAQ2 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit epsilon COG0847 Cluster_551258 V1020852 S NA 0XQ6D Cluster_440530 V1020856 SBTA G Major Facilitator 0Y0M7 Cluster_213601 V1020857 AMD E amidohydrolase COG1473 Cluster_99399 V1020858 TNP7109-5 L transposase COG2801 Cluster_717495 V1020859 YLMG S integral membrane protein COG0762 Cluster_376672 V1020860 S DivIVA domain protein 11T6K Cluster_80096 V1020861 CYDC map02010 V ABC transporter COG1132 Cluster_218221 V1020862 FLUTA_0256 L Transposase COG3464 Cluster_196794 V1020863 ADH map00010,map00051,map00071,map00350,map00363,map00591,map00625,map00626,map00650,map00830,map00980,map00982,map01100,map01110,map01120 C alcohol dehydrogenase COG1063 Cluster_345415 V1020866 M N-Acetylmuramoyl-L-alanine amidase COG3023 Cluster_850824 V1020868 HSDR V Type I Restriction COG0610 Cluster_322670 V1020871 LACR K lactose phosphotransferase system repressor COG1349 Cluster_733923 V1020872 NPDA map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_381954 V1020873 RUVA map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) COG0632 Cluster_228719 V1020875 RLX U relaxase mobilization nuclease domain protein COG3843 Cluster_720769 V1020877 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_578758 V1020878 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_899570 V1020879 RLMB J RNA methyltransferase TrmH family group 3 COG0566 Cluster_244923 V1020880 V ABC superfamily ATP binding cassette transporter ABC protein COG1131 Cluster_506668 V1020881 SARZ K Transcriptional regulator 11TPH Cluster_94613 V1020883 MNHD P subunit D COG0651 Cluster_406706 V1020884 YCIO J sua5 ycio yrdc ywlc family protein COG0009 Cluster_360086 V1020894 S Membrane 129H3 Cluster_686553 V1020895 MJLS_1669 L transposase, IS3 IS911 family protein COG2963 Cluster_281465 V1020896 AARI_35290 L integrase catalytic COG2801 Cluster_482155 V1020897 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_390811 V1020898 AHPC O C-terminal domain of 1-Cys peroxiredoxin COG0450 Cluster_303368 V1020901 map02010 P ABC, transporter COG1120 Cluster_82058 V1020902 S Protein of unknown function (DUF1524) COG1479 Cluster_95110 V1020903 I, Q amp-dependent synthetase and ligase COG0318 Cluster_353442 V1020905 PHOB map02020 T Response regulator receiver domain protein COG0745 Cluster_389059 V1020906 HISB map00340,map01100,map01110,map01230 E imidazole-glycerol-phosphate dehydratase COG0131 Cluster_232204 V1020907 EXOA map03410 L Exodeoxyribonuclease III COG0708 Cluster_296559 V1020908 YBJI S Hydrolase COG0561 Cluster_136535 V1020909 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_421148 V1020910 YABB map00340,map00350,map00624,map01120 L Methyltransferase COG4123 Cluster_464686 V1020911 YAAT S psp1 domain protein COG1774 Cluster_566155 V1020912 LPRD K Lipoprotein lprD COG4578 Cluster_613263 V1020913 RV1342C S Membrane 1240U Cluster_270817 V1020914 SCLAV_3828 K deoR family transcriptional regulator COG1349 Cluster_710820 V1020916 RPOZ map00230,map00240,map01100,map03020 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) COG1758 Cluster_91773 V1020918 GABD2 map00250,map00350,map00650,map01100,map01120 C succinate-semialdehyde dehydrogenase COG1012 Cluster_799896 V1020921 TENI map00730,map01100 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) COG0352 Cluster_177629 V1020922 THIO map00730 E Glycine oxidase COG0665 Cluster_311979 V1020924 YBBP S TIGR00159 family COG1624 Cluster_318125 V1020925 NFSA map00051,map00190,map00363,map00591,map00625,map00633,map00650,map01100,map01120 C nitroreductase COG0778 Cluster_491592 V1020926 L Replication Protein COG5655 Cluster_432573 V1020927 L decarboxylase COG1611 Cluster_698508 V1020934 MENC map00130,map01100,map01110 H O-succinylbenzoate synthase COG4948 Cluster_217104 V1020935 MENB map00130,map00360,map01100,map01110,map01120 H Naphthoate synthase COG0447 Cluster_757732 V1020936 PDXY map00750,map01100 H functions in a salvage pathway. Uses pyridoxamine (By similarity) COG2240 Cluster_99400 V1020937 AMET_0415 S phage protein 0Y97T Cluster_376673 V1020943 NUDF map00230 F nudix hydrolase COG0494 Cluster_376674 V1020944 XERD L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_506669 V1020945 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_265425 V1020946 NIKC map02010 P ABC transporter (Permease COG1173 Cluster_799897 V1020947 YYZM S protein, conserved in bacteria COG4481 Cluster_183646 V1020948 YCHF J gtp-binding protein COG0012 Cluster_276143 V1020949 map00260,map00670,map00910,map01100 E Aminomethyltransferase folate-binding domain 0YP69 Cluster_548278 V1020950 J endoribonuclease L-psp COG0251 Cluster_304887 V1020951 MAZG map00230,map00240,map01100 F mazG family COG1694 Cluster_142649 V1020952 DAPE map00300,map00330,map01100,map01110,map01120,map01210,map01230 E Acetylornithine deacetylase COG0624 Cluster_804259 V1020955 SECE map03060,map03070 U Preprotein translocase SecE subunit 125W8 Cluster_444553 V1020956 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_643895 V1020958 S NA 0ZHU9 Cluster_426665 V1020959 MOAB2 H molybdenum cofactor biosynthesis protein COG0521 Cluster_631960 V1020961 S NA 11HBJ Cluster_899571 V1020962 S NA 0ZHU9 Cluster_613265 V1020963 CG2428 S rdd domain containing protein 11WIF Cluster_336279 V1020964 SCLAV_1126 map02010 V (ABC) transporter COG0842 Cluster_536671 V1020965 CTAA map00190,map00860,map01100,map01110,map02020 O cytochrome oxidase assembly COG1612 Cluster_808209 V1020966 S Zinc iron permease 127TF Cluster_647918 V1020967 CZRA K Transcriptional regulator, arsr family COG0640 Cluster_504187 V1020969 ZNTA P ATPase (EC 3.6.3.-) COG2217 Cluster_217105 V1020970 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_551260 V1020971 S Pfam:DUF299 0YNP9 Cluster_361655 V1020972 S NA 11YTD Cluster_808210 V1020973 LGAS_0607 T head morphogenesis protein, SPP1 gp7 COG5585 Cluster_269497 V1020975 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_673132 V1020981 L DNA binding protein, excisionase family 0YKT7 Cluster_299211 V1020982 AARI_35290 L integrase catalytic COG2801 Cluster_668865 V1020983 MJLS_1669 L transposase, IS3 IS911 family protein COG2963 Cluster_484462 V1020985 T serine threonine protein kinase COG0515 Cluster_444554 V1020990 S Domain of Unknown Function (DUF1599) 0XPSN Cluster_351758 V1020991 map02020 T Two component transcriptional regulator (Winged helix family COG0745 Cluster_155967 V1020992 M RHS repeat-associated core domain protein COG3209 Cluster_331777 V1020995 BTUF map02010 P Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) COG0614 Cluster_265426 V1020996 S NA 0XPA9 Cluster_86751 V1020997 map00550,map01100 M glycosyl transferase, family 51 COG0744 Cluster_153499 V1020999 PQQE K radical SAM domain protein COG0535 Cluster_337797 V1021000 RECO map03440 L Involved in DNA repair and RecF pathway recombination (By similarity) 0XR7P Cluster_444937 V1209802 ADHE map00010,map00051,map00071,map00350,map00362,map00363,map00591,map00620,map00621,map00622,map00625,map00626,map00650,map01100,map01110,map01120 C Dehydrogenase COG1454 Cluster_380542 V1209804 GLPG S Rhomboid family COG0705 Cluster_345738 V1209806 RPIA map00030,map00710,map01100,map01110,map01120,map01230 G phosphoriboisomerase A COG0120 Cluster_401775 V1209809 YCHF J gtp-binding protein COG0012 Cluster_218458 V1209811 ARGF map00330,map01100,map01110,map01230 E ornithine carbamoyltransferase COG0078 Cluster_557655 V1209812 map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020 C fumarate reductase flavoprotein, subunit COG1053 Cluster_728099 V1209814 S NA 0ZHU9 Cluster_692063 V1209815 ACYP map00620,map00627,map01120 C Acylphosphatase COG1254 Cluster_573168 V1209816 S NA 0YNCM Cluster_705300 V1209821 S Membrane 11YSX Cluster_336566 V1209826 YBJB S integral membrane protein COG4858 Cluster_198882 V1209827 TRMFO J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) COG1206 Cluster_186478 V1209828 S phage tape measure protein COG5283 Cluster_231256 V1209835 RPOD map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_399988 V1209837 S Lpxtg-motif cell wall anchor domain protein 0Y44U Cluster_417934 V1209839 M ErfK YbiS YcfS YnhG COG1376 Cluster_245144 V1209840 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_748034 V1209844 S NA 0ZHU9 Cluster_434879 V1209845 YTTB G Major Facilitator 0ZVV9 Cluster_237283 V1209847 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_237284 V1209851 YAGE E amino acid COG0531 Cluster_792937 V1209857 CPS1D map00051 S biosynthesis protein 0XQI4 Cluster_371943 V1209862 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_249040 V1209869 METY map00270,map01100 E o-acetylhomoserine COG2873 Cluster_333531 V1209876 GLNQ E abc transporter atp-binding protein COG1126 Cluster_387701 V1209877 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_287322 V1209880 LDB1874 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_272374 V1209882 RNY S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 Cluster_744673 V1209894 G Major Facilitator superfamily 0ZW4V Cluster_284477 V1209895 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_298174 V1209899 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_289973 V1209900 PIPD E Dipeptidase COG4690 Cluster_292645 V1209902 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_731400 V1209903 SP_1801 S integral membrane protein COG2261 Cluster_480337 V1209905 BLAI K Transcriptional regulator COG3682 Cluster_494583 V1209907 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_387702 V1209909 MDH map00051,map01100 E Dehydrogenase COG1063 Cluster_416135 V1209910 LEMA S LemA family COG1704 Cluster_352051 V1209911 S B3 4 domain protein COG3382 Cluster_306548 V1209913 M Sulfatase COG1368 Cluster_309278 V1209915 HTRA O serine protease COG0265 Cluster_657005 V1209917 S NA 0XNUC Cluster_509853 V1209918 S NA 0XNUC Cluster_401776 V1209919 K HTH_XRE 0XUC3 Cluster_504684 V1209920 NHAC map00680 C Na H antiporter COG1757 Cluster_758443 V1209921 V Inherit from COG: (ABC) transporter COG1131 Cluster_579483 V1209922 K Transcriptional regulator, GntR family COG1725 Cluster_342520 V1209926 COBQ S Glutamine amidotransferase COG3442 Cluster_316849 V1209928 G phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 COG2211 Cluster_432957 V1209933 S Cbs domain protein COG0517 Cluster_322944 V1209935 CPO S hydrolase COG0596 Cluster_475721 V1209938 S NA 0ZHU9 Cluster_484972 V1209939 S NA 0ZHU9 Cluster_458848 V1209940 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_471469 V1209943 S NA 0ZHU9 Cluster_414349 V1209946 S ABC transporter, ATP-binding protein COG0488 Cluster_477922 V1209949 NTH map03410 L endonuclease III COG0177 Cluster_338107 V1209950 PARC L DNA topoisomerase IV, subunit A COG0188 Cluster_339543 V1209952 PCPA map00051 S surface protein 11WKM Cluster_361980 V1209956 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_436925 V1209958 PSAA map02010 P ABC transporter COG0803 Cluster_711521 V1209963 S NA 0ZHU9 Cluster_350549 V1209965 MLER K malolactic fermentation system COG0583 Cluster_456880 V1209967 S Putative amino acid metabolism 122BZ Cluster_407055 V1209968 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_357076 V1209971 RIHB map00230,map00240,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_363550 V1209973 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_751462 V1209974 SCRK map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G fructokinase COG1940 Cluster_371944 V1209980 POTD map02010 E ABC transporter COG0687 Cluster_373556 V1209983 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_599578 V1209988 SP_0145 G Major Facilitator COG0477 Cluster_576390 V1209990 ARGG map00250,map00330,map01100,map01110,map01230 E Citrulline--aspartate ligase COG0137 Cluster_504685 V1209993 NRDI F NrdI protein COG1780 Cluster_385854 V1209994 SASC S surface protein 11FPX Cluster_499750 V1209996 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_748036 V1209997 S NA 0ZHU9 Cluster_610428 V1209998 ISPA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_394754 V1210005 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_542967 V1210006 S NA 11GVV Cluster_394755 V1210007 map03440 K Transcriptional regulator COG2865 Cluster_399990 V1210018 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase ii COG0046 Cluster_399991 V1210019 FABK map00061,map01100 I 2-Nitropropane dioxygenase COG2070 Cluster_401777 V1210020 map00052,map01100,map02060 G PTS system, galactitol-specific IIc component COG3775 Cluster_450966 V1210021 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_410667 V1210022 map03030 S Caulimovirus viroplasmin COG3341 Cluster_405364 V1210023 COABC map00770,map01100 H Phosphopantothenoylcysteine decarboxylase COG0452 Cluster_554736 V1210025 TRXB map00240,map00450 C ferredoxin--nadp reductase COG0492 Cluster_407056 V1210030 GEOTH_0480 L Integrase catalytic subunit COG4584 Cluster_425148 V1210032 PPIB O PPIases accelerate the folding of proteins COG0652 Cluster_816834 V1210036 S NA 0ZHU9 Cluster_410668 V1210040 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_531608 V1210044 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_419706 V1210049 COMEC S Competence protein COG2333 Cluster_419707 V1210050 CBPC M choline binding protein COG5263 Cluster_425149 V1210053 LYTS map02020 T Histidine kinase COG3275 Cluster_423364 V1210054 PBP2B map00550,map01100 M penicillin-binding protein COG0768 Cluster_573170 V1210055 YFNA E amino acid COG0531 Cluster_423365 V1210056 PYRP F permease COG2233 Cluster_450967 V1210062 RPSK map03010 J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) COG0100 Cluster_428972 V1210064 YCGA S c4-dicarboxylate anaerobic carrier COG1288 Cluster_428973 V1210066 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_430950 V1210068 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_471470 V1210071 S NA 11Z45 Cluster_537292 V1210080 ISPE map00900,map01100,map01110 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COG1947 Cluster_657006 V1210081 S Protein of unknown function (DUF1064) 0YJBM Cluster_475722 V1210082 YACL S PilT protein domain protein COG4956 Cluster_434880 V1210083 L Recombinase COG1961 Cluster_436926 V1210084 PEPV map00300,map00480,map01100,map01120,map01230 E Dipeptidase COG0624 Cluster_621504 V1210088 GPPA map00230 F, P ppx gppa phosphatase COG0248 Cluster_596064 V1210094 S NA 0ZHU9 Cluster_448997 V1210095 L adenine specific DNA methyltransferase COG4889 Cluster_446970 V1210097 PROC map00330,map01100,map01110,map01230 E pyrroline-5-carboxylate reductase COG0345 Cluster_640888 V1210101 DLTA map00473,map05150 H Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) COG1020 Cluster_452919 V1210105 TLYC P CBS domain protein COG1253 Cluster_528814 V1210113 S Uncharacterized conserved protein (DUF2075) COG3410 Cluster_458849 V1210114 S Membrane 0XQ5Q Cluster_458850 V1210116 RNJB map03018 O Metallo-Beta-Lactamase COG0595 Cluster_714914 V1210119 S Uncharacterized protein conserved in bacteria (DUF2252) COG4320 Cluster_892032 V1210120 GALM map00010,map01110,map01120 G converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) COG2017 Cluster_648812 V1210124 S Saccharopine dehydrogenase related protein 0XWVV Cluster_463019 V1210126 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_528815 V1210130 PYRF map00240,map01100 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) COG0284 Cluster_724837 V1210133 IOLS C aldo keto reductase COG0667 Cluster_467185 V1210135 MDH map00051,map01100 E Dehydrogenase COG1063 Cluster_471471 V1210142 YFHO S Membrane COG4485 Cluster_473582 V1210143 S NA 17M0X@proNOG Cluster_545920 V1210147 CADA P p-type atpase COG2217 Cluster_475723 V1210152 G Major Facilitator Superfamily 11M79 Cluster_475724 V1210154 S Membrane COG1434 Cluster_477923 V1210155 ARTM2 E amino acid AbC transporter COG0765 Cluster_477924 V1210157 HPK31 T Histidine kinase COG0642 Cluster_554737 V1210158 YAGE E amino acid COG0531 Cluster_477925 V1210159 C Inherit from bactNOG: reductase COG0656 Cluster_480338 V1210162 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_489602 V1210164 LPLA map00785,map01100 H Lipoate-protein, ligase COG0095 Cluster_480339 V1210167 NNRD G Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) COG0063 Cluster_548973 V1210170 MYCA S Myosin-Cross-Reactive Antigen COG4716 Cluster_515136 V1210171 AZLC E azlc family COG1296 Cluster_614065 V1210176 S NA 0ZHU9 Cluster_657007 V1210178 XSEB map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1722 Cluster_855459 V1210179 ISPA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_487248 V1210181 ARCD E Arginine ornithine antiporter COG0531 Cluster_489603 V1210182 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_687501 V1210183 S NA 0ZHU9 Cluster_489604 V1210186 SP_1529 M Polysaccharide Biosynthesis Protein COG2244 Cluster_492102 V1210188 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_744674 V1210189 MRED M Rod shape-determining protein MreD 1294E Cluster_569955 V1210194 ARCD S c4-dicarboxylate anaerobic carrier COG1288 Cluster_492104 V1210195 M Glycosyl transferase, family 2 COG1215 Cluster_621505 V1210198 S NA 0ZHU9 Cluster_809074 V1210200 K Transcriptional regulator COG1733 Cluster_497094 V1210201 S NA 11NI8 Cluster_499752 V1210203 YJEM E Inner membrane transporter yjeM 174IZ@proNOG Cluster_629008 V1210206 FLD C Flavodoxin COG0716 Cluster_504686 V1210208 SECA2 map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_560728 V1210212 RECG map03440 L ATP-dependent DNA helicase recG COG1200 Cluster_504688 V1210215 PEPN map00480,map01100 E Aminopeptidase COG0308 Cluster_512432 V1210224 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_512433 V1210226 TILS map00230,map00983,map01100,map01110 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) COG0037 Cluster_512434 V1210228 NHAC map00680 C Na H antiporter COG1757 Cluster_512436 V1210236 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_932015 V1210237 P Ion channel COG1226 Cluster_515137 V1210238 PRIA map03440 L Primosomal protein n' COG1198 Cluster_534390 V1210240 AZR S Nadph-dependent fmn reductase COG2461 Cluster_515138 V1210243 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_515139 V1210244 SUFD O feS assembly protein SufD COG0719 Cluster_531609 V1210245 TCYC map02010 E ABC transporter, ATP-binding protein COG1126 Cluster_528816 V1210252 YEBR T gaf domain protein COG1956 Cluster_517813 V1210253 GREA2 K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) COG0782 Cluster_636858 V1210256 map00300,map00330,map01100,map01110,map01120,map01210,map01230 E Acetylornithine deacetylase COG0624 Cluster_520358 V1210257 S Membrane COG0628 Cluster_523126 V1210260 HELD map03420,map03430 L helicase COG3973 Cluster_523127 V1210261 PTSI map00051,map01100,map02060 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) COG1080 Cluster_557657 V1210262 RPSK map03010 J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) COG0100 Cluster_523128 V1210263 CBPE map00500,map02020 M choline binding protein COG5263 Cluster_702231 V1210270 PPK map00190,map03018 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) COG0855 Cluster_528817 V1210275 YUNF S Conserved Protein COG1801 Cluster_528818 V1210276 LMRA map02010 V ABC transporter COG1132 Cluster_528819 V1210277 CELB map00052,map01100,map02060 G iic component COG1455 Cluster_528820 V1210281 MUTM map03410 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) COG0266 Cluster_534391 V1210287 NAPA2 P Na H antiporter COG0569 Cluster_534392 V1210291 FTSK D cell division protein FtsK COG1674 Cluster_537293 V1210293 MUTL map03430 L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) COG0323 Cluster_773571 V1210296 S Membrane COG0628 Cluster_813044 V1210299 S Hydrolase COG4814 Cluster_537295 V1210302 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_540096 V1210304 PSTS map02010,map02020,map05152 P phosphate COG0226 Cluster_632823 V1210305 SECA2 map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_540097 V1210310 LPLA map00785,map01100 H Lipoate-protein, ligase COG0095 Cluster_540098 V1210311 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_540099 V1210313 O Matrixin COG5549 Cluster_542969 V1210315 PEPX E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) 0XPUZ Cluster_542970 V1210316 T metallophosphoesterase COG0639 Cluster_545921 V1210320 S Inherit from NOG: domain protein 0XP4A Cluster_545922 V1210321 YHCG V abc transporter atp-binding protein COG1131 Cluster_545923 V1210322 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_545924 V1210324 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_579485 V1210330 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_548974 V1210331 GLNA map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG0174 Cluster_548975 V1210333 FTSW map04112 D cell division protein COG0772 Cluster_551878 V1210334 AZLC E azlc family COG1296 Cluster_551879 V1210336 SP_1245 S hydrolase COG0561 Cluster_554738 V1210341 TRMB C Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_554739 V1210342 G Major Facilitator 101QG Cluster_554740 V1210349 YFMM S ABC transporter, ATP-binding protein COG0488 Cluster_554742 V1210356 HASA M Glycosyl transferase, family 2 COG1215 Cluster_557658 V1210362 G Drug resistance transporter EmrB QacA 0XNN3 Cluster_678558 V1210364 G, K ROK family COG1940 Cluster_921357 V1210375 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_563673 V1210378 YAJC map03060,map03070 U preprotein translocase, subunit YajC COG1862 Cluster_563674 V1210379 LMRC map02010 V ABC transporter COG1132 Cluster_737941 V1210381 S NA 0ZBK7 Cluster_569956 V1210382 MURE map00300,map00550 M mur ligase COG0769 Cluster_569957 V1210386 map02020 V ABC transporter, permease COG0577 Cluster_573171 V1210387 RLUD J Pseudouridine synthase COG0564 Cluster_828460 V1210388 GLPT G transporter 0XPWC Cluster_699144 V1210389 S SAM-dependent methyltransferase 0YNVR Cluster_573172 V1210390 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_573173 V1210394 LACZ map00052,map00511,map00600,map01100 G beta-galactosidase COG3250 Cluster_836072 V1210396 PEPN map00480,map01100 E Aminopeptidase COG0308 Cluster_762185 V1210397 PEPN map00480,map01100 E Aminopeptidase COG0308 Cluster_576391 V1210399 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_576393 V1210404 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_824627 V1210405 LPCA M Glycosyl transferase family 8 COG1442 Cluster_576394 V1210406 YAGE E amino acid COG0531 Cluster_610429 V1210408 PBP2B map00550,map01100 M penicillin-binding protein COG0768 Cluster_579486 V1210410 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_705303 V1210411 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_582725 V1210413 YIBE S YibE F family protein COG5438 Cluster_582726 V1210414 LTRA S low temperature requirement protein COG4292 Cluster_585920 V1210422 S Membrane COG4485 Cluster_585921 V1210423 PEPX E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) 0XPUZ Cluster_805027 V1210428 YRFA K arsR family transcriptional regulator COG0640 Cluster_828462 V1210430 map00510,map01100 M Glycosyl Transferase COG0463 Cluster_871741 V1210431 YPHH map00362,map01100,map01120 S Cupin 2, conserved barrel domain protein COG1917 Cluster_589214 V1210437 COMF S Competence protein COG1040 Cluster_592589 V1210438 GALT map00052,map00520,map01100,map01110 G UDP-glucose-hexose-1-phosphate uridylyltransferase COG4468 Cluster_606754 V1210441 S Membrane COG4485 Cluster_592590 V1210443 GLNQ map02010 E abc transporter atp-binding protein COG1126 Cluster_629009 V1210444 MDH map00051,map01100 E Dehydrogenase COG1063 Cluster_596065 V1210449 GLNK map02020 T Histidine kinase COG0642 Cluster_632825 V1210451 TRML map04122 J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) COG0219 Cluster_683094 V1210452 S Fic/DOC family 0ZXM7 Cluster_828464 V1210455 XPT map00230,map01100,map01110 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) COG0503 Cluster_599580 V1210456 M phosphoglycerol transferase alkaline phosphatase superfamily protein COG1368 Cluster_603140 V1210458 PRKC T serine threonine protein kinase COG2815 Cluster_599581 V1210460 YUFN S basic membrane COG1744 Cluster_603141 V1210461 PSAA map02010 P ABC transporter COG0803 Cluster_632826 V1210462 RIBT S reductase 121UC Cluster_603142 V1210463 RIBF map00740,map01100 H riboflavin biosynthesis protein ribF COG0196 Cluster_603143 V1210464 GLPT G transporter 0XPWC Cluster_603144 V1210465 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_603145 V1210467 GPMA1 map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0588 Cluster_606755 V1210473 ARCD E Arginine ornithine antiporter COG0531 Cluster_724841 V1210478 LPLA map00785,map01100 H Lipoate-protein ligase COG0095 Cluster_702233 V1210480 CYDA map00190,map01100,map02020 C (Ubiquinol oxidase) subunit I COG1271 Cluster_606757 V1210481 CPS1C M polysaccharide biosynthesis protein COG2244 Cluster_748037 V1210482 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_610430 V1210486 PATA map00300,map01100,map01110,map01230 E Aminotransferase COG0436 Cluster_614067 V1210487 CELB map02060 G pts system 124SH Cluster_614068 V1210490 map03420 K, L transcription-repair coupling factor COG1197 Cluster_839927 V1210491 BL01171 P hemerythrin hhe cation binding domain protein COG2461 Cluster_728106 V1210493 E Peptidase family M20/M25/M40 COG2195 Cluster_714915 V1210496 SPXA K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) COG1393 Cluster_800792 V1210499 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_625296 V1210502 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (alpha subunit) COG0587 Cluster_621506 V1210503 YSLB S hydrocarbon binding protein 121J8 Cluster_708418 V1210505 S YGGT family COG0762 Cluster_625297 V1210508 S NA 0YNCM Cluster_731401 V1210509 S NA 0ZHU9 Cluster_708419 V1210510 DEOB map00030,map00230 G Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) COG1015 Cluster_871743 V1210511 S NA 11S7H Cluster_796907 V1210512 L DNA methylase COG0863 Cluster_629010 V1210513 RARA L recombination factor protein RarA COG2256 Cluster_629012 V1210515 S integral membrane protein COG0392 Cluster_629013 V1210516 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_832159 V1210517 S Protein of unknown function (DUF2922) 0XZ4F Cluster_629014 V1210518 map00240,map00250,map01100 E, F CPSase_sm_chain COG0505 Cluster_629016 V1210522 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_708420 V1210523 NDK map00230,map00240,map01100,map01110 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) COG0105 Cluster_632827 V1210524 PATA map00300,map01100,map01110,map01230 E Aminotransferase COG0436 Cluster_758448 V1210525 YYCI S YycI protein COG4853 Cluster_657010 V1210527 E Arginine ornithine antiporter COG0531 Cluster_816838 V1210528 MVK map00900,map01100,map01110,map04146 I mevalonate kinase COG1577 Cluster_636859 V1210529 GLTP C proton sodium-glutamate symport protein COG1301 Cluster_640889 V1210532 DEGV S degv family COG1307 Cluster_652883 V1210533 PSTB2 map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_644757 V1210539 L adenine specific DNA methyltransferase COG4889 Cluster_766155 V1210545 PARE L DNA topoisomerase IV (Subunit B) COG0187 Cluster_687503 V1210547 YJCE P Na H antiporter COG0025 Cluster_728107 V1210548 S tpr repeat-containing protein 11U03 Cluster_728108 V1210550 YJJP S Membrane COG2966 Cluster_652884 V1210554 OCAR_5722 G, M Nad-dependent epimerase dehydratase COG0702 Cluster_657011 V1210561 RES L resolvase COG1961 Cluster_661244 V1210565 GLNQ E abc transporter atp-binding protein COG1126 Cluster_661246 V1210567 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_777296 V1210573 V Beta-lactamase class C related penicillin binding protein COG1680 Cluster_674101 V1210579 TRMD map00900,map01100,map01110 J Specifically methylates guanosine-37 in various tRNAs (By similarity) COG0336 Cluster_674102 V1210581 PEPN map00480,map01100 E Aminopeptidase COG0308 Cluster_674103 V1210584 DIVIVA D Cell division protein DIVIVA COG3599 Cluster_674104 V1210585 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_674105 V1210587 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_741386 V1210591 PNB C Nitroreductase COG0778 Cluster_674106 V1210592 MUTS2 map03430 L muts2 protein COG1193 Cluster_683095 V1210597 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_203964 V1210611 OPPA E ABC transporter COG0747 Cluster_17494 V1210612 S Rib/alpha-like repeat 10008 Cluster_47693 V1210615 SP_1492 S cell wall surface anchor family protein 0YURI Cluster_484973 V1210631 S NA 0ZHU9 Cluster_135061 V1210633 DACA map00550,map01100 M carboxypeptidase COG1686 Cluster_652885 V1210634 S NA 0ZHU9 Cluster_669723 V1210636 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_548977 V1210642 YUFN S basic membrane COG1744 Cluster_855466 V1210671 S NA 0ZHU9 Cluster_737946 V1210675 S NA 0ZHU9 Cluster_566867 V1210682 GATB map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 Cluster_298175 V1210687 YHAM S Metal Dependent Phosphohydrolase COG3481 Cluster_428974 V1210695 S NA 0ZHU9 Cluster_380543 V1210699 TMK map00240,map01100 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) COG0125 Cluster_473583 V1210703 S NA 0ZHU9 Cluster_569959 V1210723 S NA 0ZHU9 Cluster_339544 V1210742 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_340994 V1210743 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_344109 V1210744 PEPC E aminopeptidase c COG3579 Cluster_748042 V1210751 RPLJ map03010 J 50s ribosomal protein L10 COG0244 Cluster_482648 V1210752 LYTR K TRANSCRIPTIONal COG1316 Cluster_355385 V1210753 C FMN-dependent alpha-hydroxy acid dehydrogenase COG1304 Cluster_361981 V1210756 PURB map00230,map00250,map01100,map01110 F adenylosuccinate lyase COG0015 Cluster_366995 V1210762 S NA 11NI8 Cluster_502296 V1210767 S NA 0Y2WH Cluster_731403 V1210768 YKCB M glycosyl transferase, family 39 COG1807 Cluster_640890 V1210797 YLBN S Nucleic acid-binding protein COG1399 Cluster_579489 V1210810 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_678562 V1210813 S NA 0Z01C Cluster_674107 V1210818 S NA 0ZHU9 Cluster_728111 V1210828 S NA 0ZHU9 Cluster_444938 V1210829 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (alpha subunit) COG0587 Cluster_661247 V1210831 S NA 0ZHU9 Cluster_640891 V1210856 S NA 0ZHU9 Cluster_721491 V1210884 SILP S secreted protein containing plastocyanin domain COG4633 Cluster_805033 V1210895 S NA 0ZHU9 Cluster_721493 V1210896 V prophage pi1 protein 32 COG1403 Cluster_492106 V1210897 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_515140 V1210919 POTA map02010 E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COG3842 Cluster_683096 V1210970 J acetyltransferase, (GNAT) family COG1670 Cluster_548978 V1210974 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_548979 V1210978 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_551881 V1210982 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_579491 V1211020 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_579492 V1211021 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_640893 V1211038 S NA 0ZHU9 Cluster_592591 V1211045 HELD map03420,map03430 L helicase COG3973 Cluster_603148 V1211064 MDLB map02010 V ABC transporter COG1132 Cluster_661248 V1211070 map00052,map01100,map02060 G PTS System COG3414 Cluster_661249 V1211121 G Drug resistance transporter EmrB QacA 0XNN3 Cluster_669725 V1211126 ATOB map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map02020 I Acetyl-CoA acetyltransferase COG0183 Cluster_678564 V1211128 METI map02010 P ABC transporter, permease COG2011 Cluster_687508 V1211140 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_23423 V1211145 S Lipase (class 3) 0ZJUJ Cluster_71824 V1211146 S Bacteriophage peptidoglycan hydrolase 0ZNE8 Cluster_361982 V1211150 SRTA M (sortase) family COG3764 Cluster_200882 V1211151 S NA 0Y8RQ Cluster_198883 V1211153 LGAS_0621 S Phage cell wall hydrolase 0XSRY Cluster_8092 V1211154 BL00969 S NA 0XYM3 Cluster_116280 V1211155 XKDK S phage protein 0XRSE Cluster_528821 V1211157 LGAS_0613 S phage protein 125MW Cluster_436927 V1211158 LGAS_0609 S Phage minor structural protein GP20 123J7 Cluster_103998 V1211159 LGAS_0606 S Phage Portal Protein 0XP33 Cluster_796912 V1211160 S NA 0Z156 Cluster_504689 V1211162 RUSA L endodeoxyribonuclease RusA COG4570 Cluster_322945 V1211163 K Phage antirepressor protein KilAC domain COG3645 Cluster_253992 V1211164 S NA 123QA Cluster_112 V1211165 S NA 120ST Cluster_13210 V1211166 S Inherit from NOG: LPXTG-motif cell wall anchor domain protein 0YEBJ Cluster_112035 V1211168 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_116993 V1211169 K, L domain protein COG0553 Cluster_499756 V1211170 S Phage-Associated Protein 120JX Cluster_669 V1211172 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_377042 V1211173 SP_0721 map02010 P transporter, permease 11MR9 Cluster_338108 V1211175 YDHQ K Transcriptional regulator COG2188 Cluster_43321 V1211176 FRUA map00051,map01100,map02060 G PTS System COG1445 Cluster_18131 V1211182 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_27271 V1211183 V Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) COG1136 Cluster_6317 V1211184 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_50573 V1211185 SP_0577 map00010,map00500,map00520,map02060 G pts system COG2190 Cluster_336567 V1211186 CPHY_2173 L Transposase 11J2V Cluster_378819 V1211187 PGM3 map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_520360 V1211188 S NA 11PZT Cluster_436928 V1211189 AZR S Nadph-dependent fmn reductase COG0431 Cluster_305163 V1211190 ZNUB map02010 P ABC, transporter COG1108 Cluster_176123 V1211191 S Minor capsid protein 0Y58E Cluster_72156 V1211192 S minor capsid protein 0XSIM Cluster_127486 V1211193 L Phage terminase, large subunit COG1783 Cluster_363552 V1211194 S NA 11XM2 Cluster_398270 V1211196 S Bacteriophage Gp15 protein 11NHP Cluster_253993 V1211198 BGLA1 map00010 G Glycosyl hydrolase family 1 COG2723 Cluster_14977 V1211199 M Phage minor structural protein COG4926 Cluster_74483 V1211200 GLNP E ABC transporter COG0834 Cluster_130333 V1211201 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_528822 V1211202 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_37951 V1211203 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_280356 V1211204 DPRA L DNA protecting protein DprA COG0758 Cluster_324521 V1211205 RNHB map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0164 Cluster_108178 V1211206 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_6893 V1211207 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_108179 V1211211 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_96806 V1211212 map00052,map01100,map02060 G PTS system, galactitol-specific IIc component COG3775 Cluster_56764 V1211213 C Fumarate reduCtase COG1053 Cluster_291286 V1211214 BL00871 S Phage tail protein 1222P Cluster_20222 V1211215 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_116281 V1211216 G Major Facilitator Superfamily 11M79 Cluster_272375 V1211218 map02010 P binding-protein-dependent transport systems inner membrane Component COG1175 Cluster_283105 V1211219 LACT K antiterminator COG3711 Cluster_65392 V1211220 LACE map00052,map01100,map02060 G pts system, lactose-specific COG1455 Cluster_101137 V1211221 LACG map00052,map01100 G Glycosyl hydrolase family 1 COG2723 Cluster_29571 V1211222 UVRD map03420,map03430 L ATP-dependent DNA helicase pcra COG0210 Cluster_579494 V1211223 ELI_1301 S Phage head-tail adaptor COG5614 Cluster_138234 V1211224 BL03502 O phage portal protein HK97 family COG4695 Cluster_97351 V1211227 YCAM E amino acid COG0531 Cluster_24282 V1211228 YFGQ P Cation-transporting atpase COG0474 Cluster_98434 V1211229 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_338109 V1211230 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_434881 V1211231 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_49365 V1211232 L SNF2 family DNA RNA helicase COG0553 Cluster_41518 V1211233 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_59585 V1211234 DXS map00730,map00900,map01100,map01110 H, I Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) COG1154 Cluster_130334 V1211235 PURB map00230,map00250,map01100,map01110 F adenylosuccinate lyase COG0015 Cluster_377043 V1211236 GLNP map02010 E amino acid AbC transporter COG0765 Cluster_460899 V1211237 RIMP S Required for maturation of 30S ribosomal subunits (By similarity) COG0779 Cluster_141988 V1211238 NUSA K Transcription elongation factor NusA COG0195 Cluster_421506 V1211239 K family Transcriptional regulator 0XUC3 Cluster_245145 V1211240 DACA map00550,map01100 M carboxypeptidase COG1686 Cluster_151213 V1211241 SBND G Major Facilitator 0ZVCH Cluster_96286 V1211246 LACG map00052,map01100 G Glycosyl hydrolase family 1 COG2723 Cluster_262959 V1211248 L Site-specific recombinase COG1961 Cluster_207227 V1211249 PLSX map00561,map00564,map01100 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) COG0416 Cluster_205039 V1211250 OPPD E, P ABC transporter COG0444 Cluster_384095 V1211251 RIBU S Membrane COG3601 Cluster_73511 V1211254 RNY S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 Cluster_111428 V1211255 S integral membrane protein 0XS1S Cluster_127487 V1211256 YDAM map00051,map00561,map01100 M Glycosyl transferase, family 2 COG1215 Cluster_272376 V1211257 EPSV M glycosyltransferase group 2 family protein COG0463 Cluster_35706 V1211258 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_380544 V1211261 S CAAX amino terminal protease family protein 0XUJM Cluster_237285 V1211265 LYSA2 M Glyco_25 COG3757 Cluster_110738 V1211268 TLYC P CBS domain protein COG1253 Cluster_582730 V1211273 PTHA map00051,map02060 G PTS system glucitol sorbitol-specific 1253B Cluster_207228 V1211274 YKGB map00030,map01100,map01110,map01120 G 6-phosphogluconolactonase (EC 3.1.1.31) COG2706 Cluster_339545 V1211275 L Membrane COG4905 Cluster_245146 V1211276 LSA_08620 S Lysm domain protein 11U6T Cluster_21221 V1211279 PEPN map00480,map01100 E Aminopeptidase COG0308 Cluster_49366 V1211280 ELI_1296 L Terminase, large subunit COG4626 Cluster_264345 V1211281 YQHA G aldose 1-epimerase COG2017 Cluster_156098 V1211284 S Phage Portal Protein COG4695 Cluster_347308 V1211285 map04112 O ATP-dependent Clp protease, proteolytic subunit COG0740 Cluster_195297 V1211286 GPSA map00564 C NADPH-dependent glycerol-3-phosphate dehydrogenase COG0240 Cluster_284478 V1211287 LGT M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 Cluster_592592 V1211292 RBFA J Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) COG0858 Cluster_250304 V1211293 APPC map02010 P ABC superfamily ATP binding cassette transporter ABC protein COG1173 Cluster_55242 V1211294 C NADPH-dependent FMN reductase COG1053 Cluster_224321 V1211301 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_332044 V1211302 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_139779 V1211304 YPIA S TPR repeat-containing protein COG0457 Cluster_322946 V1211307 LGG_01039 M Lyzozyme M1 (1,4-beta-N-acetylmuramidase) COG3757 Cluster_124743 V1211308 UMUC L ImpB MucB SamB family protein COG0389 Cluster_149585 V1211313 PLNI S CAAX amino terminal protease family 0XW1D Cluster_621510 V1211314 TRXA O Thioredoxin COG0526 Cluster_116282 V1211322 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_665412 V1211323 S NA 0ZHU9 Cluster_45567 V1211327 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_392949 V1211328 RELA map00230 S RelA SpoT domain protein COG2357 Cluster_352052 V1211330 S NA 0ZHU9 Cluster_427084 V1211332 K transcriptional regulator 0ZMZA Cluster_129609 V1211334 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_230084 V1211335 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG2176 Cluster_107629 V1211337 G Major Facilitator 0ZXAG Cluster_330480 V1211339 COMEA L Competence protein COG1555 Cluster_176124 V1211343 L Integrase COG0582 Cluster_260341 V1211344 YPJC S YitT family COG1284 Cluster_85910 V1211345 ATPA map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_683098 V1211347 S NA 0ZHU9 Cluster_512437 V1211349 S GtrA-like protein 0XV3V Cluster_252734 V1211358 GALU map00040,map00052,map00500,map00520,map01100,map01110 M UTP-glucose-1-phosphate uridylyltransferase COG1210 Cluster_101697 V1211359 PIPD E Dipeptidase COG4690 Cluster_257712 V1211362 YPBG map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G, K ROK family COG1940 Cluster_164486 V1211365 RECX map00561,map01100 M Glycosyl transferase (Group 1 COG0438 Cluster_344110 V1211366 NRDG O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) COG0602 Cluster_306549 V1211367 LGAS_0585 K phage anti-repressor protein COG3561 Cluster_387703 V1211369 RBSU G Ribose uptake protein RbsU COG4975 Cluster_89056 V1211371 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_122149 V1211372 PYRP F permease COG2233 Cluster_155290 V1211373 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_711530 V1211374 S NA 0ZHU9 Cluster_380545 V1211375 G, M oxidoreductase COG0702 Cluster_79787 V1211377 map00230,map00240 F 2',3'-cyclic-nucleotide 2'-phosphodiesterase EC 3.1.4.16 COG0737 Cluster_153650 V1211380 YFDE C L-carnitine dehydratase bile acid-inducible protein F COG1804 Cluster_260342 V1211381 L Protein of unknown function (DUF1351) 0YIT0 Cluster_665413 V1211388 S NA 0ZHU9 Cluster_499757 V1211391 S NA 0XY0U Cluster_425150 V1211392 MT0709 K Transcriptional regulator 11WKC Cluster_238600 V1211394 LYSA2 M Glyco_25 COG3757 Cluster_427085 V1211397 WECD map00350,map00362,map00627,map00642,map00903,map01120 S -acetyltransferase 11PF0 Cluster_129610 V1211402 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_340995 V1211406 HLYB map02010,map03070,map05133 V ABC, transporter COG2274 Cluster_370327 V1211408 PHOP map02020 T Transcriptional regulatory protein, C terminal 11FPD Cluster_534395 V1211409 LACA map00052,map01100 G Galactose-6-phosphate isomerase subunit LacA COG0698 Cluster_236085 V1211411 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_412488 V1211412 SPRL S SprT-like COG3091 Cluster_438966 V1211415 PAIA map00350,map00362,map00627,map00642,map00903,map01120 K Protease synthase and sporulation negative regulatory protein pai 1 COG0454 Cluster_599583 V1211421 RSFS S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) COG0799 Cluster_275053 V1211422 ORF3 S degv family COG1307 Cluster_382311 V1211427 K transcriptional Regulator LysR family 11Z5Z Cluster_249041 V1211431 GLYQ map00970 J glycyl-tRNA synthetase, alpha subunit COG0752 Cluster_599584 V1211445 GALT map00052,map00520,map01100,map01110 G UDP-glucose-hexose-1-phosphate uridylyltransferase COG4468 Cluster_492107 V1211448 PTPA T Low molecular weight phosphotyrosine protein phosphatase COG0394 Cluster_289974 V1211454 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_132635 V1211458 HIPMA_0065 L Transposase COG3328 Cluster_805037 V1211461 S NA 0ZHU9 Cluster_373558 V1211467 PLSY map00561,map00564,map01100 S Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) COG0344 Cluster_161201 V1211472 ATOB map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map02020 I Acetyl-CoA acetyltransferase COG0183 Cluster_482649 V1211473 S NA 0ZHU9 Cluster_446971 V1211481 NNRE S Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity) 124BP Cluster_209395 V1211482 YABB map00340,map00350,map00624,map01120 L Methyltransferase COG4123 Cluster_489606 V1211485 SP_1996 T Universal stress protein COG0589 Cluster_452921 V1211487 S NA 0ZHU9 Cluster_385855 V1211520 map00564,map01100 I Phosphatase COG0671 Cluster_430952 V1211521 NUDF map00230 F nudix hydrolase COG0494 Cluster_391137 V1211522 MUTF map02010 V ABC transporter, ATP-binding protein COG1131 Cluster_401778 V1211523 K HTH_XRE COG1974 Cluster_202930 V1211528 S phage tape measure protein COG5283 Cluster_380546 V1211530 YTPR J TRNA binding domain protein COG0073 Cluster_528824 V1211537 S NA 11GVV Cluster_473585 V1211549 NRDR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) COG1327 Cluster_545925 V1211550 PSIE S phosphate-starvation-inducible protein PsiE COG3223 Cluster_458851 V1211551 WECD map00350,map00362,map00627,map00642,map00903,map01120 S -acetyltransferase 11PF0 Cluster_728114 V1211563 S NA 0ZHU9 Cluster_385856 V1211575 S Acetyltransferase (GNAT) family 0XV0I Cluster_446972 V1211581 S NA 0ZHU9 Cluster_276387 V1211603 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_748048 V1211604 S NA 11GVV Cluster_405366 V1211620 MURF map00300,map00550,map01100 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) COG0770 Cluster_661251 V1211627 S NA 0ZHU9 Cluster_394756 V1211660 S NA 0ZHU9 Cluster_306550 V1211666 CPDA F serine threonine protein phosphatase COG1409 Cluster_456881 V1211680 S MutT NUDIX family protein 11JZT Cluster_427086 V1211718 LEPB map03060 U Signal peptidase i COG0681 Cluster_454944 V1211724 S NA 0ZHU9 Cluster_744689 V1211726 S NA 0ZHU9 Cluster_871757 V1211739 S NA 0ZHU9 Cluster_456882 V1211759 HSLV O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) COG5405 Cluster_399992 V1211760 PLSC map00561,map00564,map01100 I Acyl-transferase COG0204 Cluster_385857 V1211761 L decarboxylase COG1611 Cluster_748050 V1211768 S NA 0ZHU9 Cluster_432960 V1211777 YJDF S NA 11P5R Cluster_124625 V1021001 NAGB map00520,map01100,map01110 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COG0363 Cluster_542255 V1021002 SAFC map00340,map00350,map00624,map01120 S O-methyltransferase COG4122 Cluster_93210 V1021006 PYKF4 map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG0469 Cluster_747351 V1021009 XTHA map03410 L Exodeoxyribonuclease III COG0708 Cluster_788389 V1021011 K acetyltransferase COG0454 Cluster_351759 V1021014 CG2376 S NA 0XX45 Cluster_328829 V1021015 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_179343 V1021016 DALK_0234 L Transposase (IS4 family) protein COG3385 Cluster_340735 V1021017 ASPB E Aminotransferase COG0436 Cluster_278835 V1021018 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_403186 V1021023 L resolvase COG1961 Cluster_319660 V1021025 S NA 11JB6 Cluster_560062 V1021026 BIOC map00780,map01100 H Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) 11P8N Cluster_203745 V1021027 O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG0526 Cluster_158517 V1021032 YAGA L Integrase catalytic subunit 0XTHD Cluster_321094 V1021035 SCAD N, U domain protein COG3942 Cluster_89893 V1021040 RECG map03420,map03440 L transcriptioN-repair coupling factor COG1197 Cluster_823816 V1021041 RPSZ map03010 J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) COG0199 Cluster_444555 V1021042 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_101039 V1021043 P Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) COG4206 Cluster_213602 V1021044 map00240,map00250,map01100 E, F Carbamoyl phosphate synthase-like protein COG0458 Cluster_854692 V1021045 S conjugation system ATPase, TraG family 0XSHU Cluster_309019 V1021046 LTRA L reverse transcriptase COG3344 Cluster_346971 V1021048 S NA 100SX Cluster_155968 V1021049 YKNZ V ABC transporter, permease COG0577 Cluster_462584 V1021050 PABB F Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_450564 V1021055 S Cupin domain 122JN Cluster_280104 V1021060 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_462585 V1021062 S NA 0ZHE8 Cluster_333241 V1021065 K Transcriptional Regulator AraC Family 0Z5N2 Cluster_103892 V1021066 DPPA map02010 E ABC transporter substrate-binding protein COG4166 Cluster_404971 V1021067 S NA 0ZFZE Cluster_482156 V1021068 K RNA polymerase COG1595 Cluster_92283 V1021069 ACEE map00010,map00020,map00620,map00650,map01100,map01110,map01120 C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) COG2609 Cluster_353443 V1021070 YOQW S Conserved protein COG2135 Cluster_373253 V1021071 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_257469 V1021075 S Mammalian cell entry related domain protein 0YWNZ Cluster_808211 V1021076 S NA 11EN1 Cluster_175180 V1021079 PLDB map00561,map00564,map01100,map04723 I Alpha Beta Hydrolase Fold protein COG2267 Cluster_757733 V1021081 YAAA S S4 domain protein YaaA COG2501 Cluster_387324 V1021082 CCH L SCCmec staphylococcal cassette region, isolate CMFT106 COG5519 Cluster_714231 V1021083 CCRA L Cassette chromosome recombinase A COG1961 Cluster_838987 V1021084 S Zinc iron permease 127TF Cluster_496543 V1021085 GREA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) COG0782 Cluster_656168 V1021086 P transport system permease protein COG1173 Cluster_192441 V1021087 E ABC transporter substrate-binding protein COG0747 Cluster_342220 V1021088 FTSE map02010 D Cell division ATP-binding protein ftsE COG2884 Cluster_489067 V1021089 S Helix-turn-helix 102BD Cluster_380171 V1021090 S NA 0ZP1D Cluster_470993 V1021091 LSPA map03060 U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) COG0597 Cluster_240923 V1021092 HUTG map00330,map00340,map01100 E formiminoglutamate hydrolase COG0010 Cluster_221783 V1021093 MUTT1 L NUDIX hydrolase COG0494 Cluster_704619 V1021095 VAPD S Virulence-associated protein D COG3309 Cluster_199687 V1021098 GALM map00010,map01110,map01120 G converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) COG2017 Cluster_440531 V1021099 GPO map00480,map00590 O Glutathione peroxidase COG0386 Cluster_714232 V1021100 HUP L DNA-binding protein COG0776 Cluster_776535 V1021103 INFA J however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) COG0361 Cluster_595260 V1021104 RPSM map03010 J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits COG0099 Cluster_673134 V1021105 RPSK map03010 J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) COG0100 Cluster_234681 V1021106 M Transglycosylase COG5009 Cluster_371632 V1021112 YRBE Q ABC superfamily ATP binding cassette transporter permease protein COG0767 Cluster_324228 V1021113 FAT map00061,map01100 I Acyl-ACP thioesterase COG3884 Cluster_94084 V1021114 S NA 0Y4CP Cluster_691176 V1021115 SDHC map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120 C cytochrome b subunit 0YBKA Cluster_776536 V1021116 RV1590 S positive regulation by symbiont of host immune response 0XTWK Cluster_351760 V1021118 HISH map00340,map01100,map01110,map01230 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) COG0118 Cluster_772716 V1021119 T Protein tyrosine phosphatase COG0394 Cluster_114770 V1021121 L integrase family 112QY Cluster_799898 V1021125 S NA 0ZHU9 Cluster_94085 V1021129 FAS map00061,map00350,map00362,map00627,map00642,map00903,map01100,map01120 I synthase COG4982 Cluster_131742 V1021130 L Integrase COG4974 Cluster_136536 V1021131 S spore coat protein CotH 0YUJE Cluster_116903 V1021132 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_704620 V1021135 S NA 0ZHU9 Cluster_780089 V1021137 RPMC map03010 J 50s ribosomal protein l29 COG0255 Cluster_595261 V1021138 RPLN map03010 J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) COG0093 Cluster_639974 V1021139 RPLX map03010 J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) COG0198 Cluster_415801 V1021141 DNAQ2 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0847 Cluster_224123 V1021142 IDSA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_566156 V1021143 TATD L Hydrolase, tatD family COG0084 Cluster_139646 V1021144 PGN_0948 S NA 0Z217 Cluster_761330 V1021146 GLUP G transporter COG0738 Cluster_292369 V1021147 K Transcriptional regulator, MarR family 0XUB6 Cluster_180167 V1021148 S NA 122PE Cluster_635912 V1021149 CP_1013 map00520,map01100,map01110 G UTP-glucose-1-phosphate uridylyltransferase COG4284 Cluster_460462 V1021150 YDJM S Membrane-bound metal-dependent hydrolase COG1988 Cluster_717496 V1021151 S UPF0457 protein 0Z1YI Cluster_231051 V1021152 XERD L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_135735 V1021153 AMTB P ammonium transporter 0XNMH Cluster_293747 V1021154 S NA 11Z9D Cluster_452516 V1021155 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_215941 V1021156 O AhpC Tsa family 0YT1V Cluster_211386 V1021157 COBG map00860,map01100 H precorrin-3b synthase COG0155 Cluster_717497 V1021159 S ParB-like nuclease domain 0ZJMC Cluster_117588 V1021162 TNP3508A L Transposase COG3328 Cluster_150299 V1021163 S Lipoprotein 0YP1K Cluster_350217 V1021164 CBIO map02010 P abc transporter COG1122 Cluster_595262 V1021165 BIOY map02010 S bioY protein COG1268 Cluster_695139 V1021167 map00051 M glycosyltransferase group 2 family protein COG0463 Cluster_278836 V1021168 M Glycosyl transferase, family 2 COG1216 Cluster_96190 V1021169 M Inherit from NOG: Polymorphic outer membrane protein 11KKP Cluster_419280 V1021170 PANE map00770,map01100,map01110 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) COG1893 Cluster_710821 V1021176 SP_0276 S addiction module toxin, RelE StbE family COG3041 Cluster_714233 V1021179 S NA 0ZDIF Cluster_557008 V1021181 BL02553 K Transcriptional regulator COG1959 Cluster_385504 V1021182 YWNB S Nad-dependent epimerase dehydratase COG2910 Cluster_399646 V1021184 S NA 17PP9@proNOG Cluster_557009 V1021185 S NA 17U78@proNOG Cluster_269498 V1021187 S NA 12026 Cluster_428587 V1021188 EFP J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) COG0231 Cluster_652004 V1021191 CKL_1885 S Protein of unknown function (DUF1064) 1251H Cluster_494045 V1021192 S Domain of unknown function (DUF1896) 0YBI2 Cluster_477454 V1021194 S hmm pf04634 0Y5PY Cluster_602315 V1021195 L Resolvase, N terminal domain COG1961 Cluster_150300 V1021197 TRPE map00400,map01100,map01110,map01230 E anthranilate synthase component i COG0147 Cluster_761331 V1021198 S NA 0ZHU9 Cluster_582734 V1211803 S NA 0ZHU9 Cluster_718172 V1211804 S NA 0ZHU9 Cluster_683101 V1211822 S NA 0ZHU9 Cluster_744691 V1211823 S NA 0ZHU9 Cluster_762194 V1211834 S NA 0ZHU9 Cluster_705313 V1211844 S NA 0ZHU9 Cluster_573177 V1211853 S NA 0ZHU9 Cluster_766164 V1211869 S NA 0ZHU9 Cluster_674112 V1211882 S NA 0ZHU9 Cluster_599586 V1211887 YUGI J RNA binding s1 domain protein COG1098 Cluster_614075 V1211891 YPHI S Antibiotic biosynthesis monooxygenase COG1359 Cluster_450968 V1211892 S NA 0ZHU9 Cluster_487250 V1211900 GREA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) COG0782 Cluster_520361 V1211934 S NA 0ZHU9 Cluster_859450 V1211937 S NA 0ZHU9 Cluster_452922 V1211944 S NA 11VH8 Cluster_473587 V1211964 S NA 0Z376 Cluster_636866 V1211984 S NA 0ZHU9 Cluster_648818 V1211990 S NA 0ZHU9 Cluster_674114 V1212002 S NA 185WP@proNOG Cluster_789167 V1212025 S NA 0ZHU9 Cluster_560731 V1212043 S NA 0ZHU9 Cluster_582736 V1212055 S NA 0ZHU9 Cluster_499759 V1212062 S NA 0ZHU9 Cluster_551883 V1212076 S NA 0ZHU9 Cluster_754924 V1212078 S NA 0ZHU9 Cluster_805046 V1212090 S NA 0ZHU9 Cluster_695877 V1212107 S NA 0ZHU9 Cluster_800816 V1212122 S NA 0ZHU9 Cluster_636867 V1212128 S NA 0ZHU9 Cluster_652896 V1212133 S NA 0ZHU9 Cluster_820638 V1212179 S NA 0ZHU9 Cluster_596071 V1212218 S NA 0ZHU9 Cluster_582739 V1212237 K lytTr DNA-binding domain protein 0XX0T Cluster_820639 V1212273 S NA 0ZHU9 Cluster_711536 V1212278 YPHH map00362,map01100,map01120 S Cupin 2, conserved barrel domain protein COG1917 Cluster_621514 V1212315 S Uncharacterized conserved protein (DUF2075) COG3410 Cluster_652898 V1212360 G Major Facilitator 0XPHU Cluster_492108 V1212416 S NA 11GVV Cluster_33753 V1212418 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_256431 V1212419 BMUL_0473 S ABC transporter, permease COG4120 Cluster_57021 V1212421 GLPQ map00564 C glycerophosphoryl diester phosphodiesterase COG4781 Cluster_377044 V1212427 ADK map00230,map00240,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_83004 V1212434 ARLS T Histidine kinase COG0642 Cluster_299457 V1212440 LGAS_0582 S Erf family 11KYA Cluster_824644 V1212458 S NA 0ZHU9 Cluster_74181 V1212471 DEXB map00052,map00500,map01100 G trehalose-6-phosphate hydrolase (EC 3.2.1.93) COG0366 Cluster_87259 V1212480 S surface protein 11NE4 Cluster_273703 V1212482 DKG map00051,map00363,map00591,map00625,map00650,map01100,map01120 C reductase COG0656 Cluster_345739 V1212487 YCLJ T response regulator COG0745 Cluster_523130 V1212492 S Acetyltransferase (GNAT) family COG2153 Cluster_446973 V1212503 PYRR map00240,map01100 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) COG2065 Cluster_259037 V1212510 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_711540 V1212511 S NA 0ZHU9 Cluster_489607 V1212521 NRDI F Probably involved in ribonucleotide reductase function (By similarity) COG1780 Cluster_238601 V1212536 DEGV S degv family COG1307 Cluster_392950 V1212540 S NA 0YNCM Cluster_375276 V1212545 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_361983 V1212547 S Cbs domain protein COG0517 Cluster_233688 V1212550 map02010 S ABC transporter COG4152 Cluster_146510 V1212570 M Cell surface protein 11GRZ Cluster_657020 V1212581 S NA 0ZHU9 Cluster_307859 V1212582 STRA J Aminoglycoside COG3231 Cluster_467190 V1212584 CORA P transporter COG0598 Cluster_162034 V1212586 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG2812 Cluster_427087 V1212593 map00350,map00362,map00627,map00642,map00903,map01120 S -acetyltransferase 11TPW Cluster_509859 V1212594 SMPB O Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) COG0691 Cluster_599590 V1212600 S NA 0ZHU9 Cluster_231257 V1212606 MALR K transcriptional regulator COG1609 Cluster_335033 V1212622 RSUA J Pseudouridine synthase COG1187 Cluster_859465 V1212634 S NA 0ZHU9 Cluster_220804 V1212651 CLPE O ATP-dependent clp protease, ATP-binding subunit COG0542 Cluster_540102 V1212658 S toxin secretion phage lysis holin COG4824 Cluster_225500 V1212665 POXB map00620,map01100 E acetolactate synthase COG0028 Cluster_744700 V1212680 S NA 0ZHU9 Cluster_534397 V1212703 S NA 0ZHU9 Cluster_678574 V1212744 S NA 0ZHU9 Cluster_884061 V1212753 S NA 0ZHU9 Cluster_796927 V1212754 S NA 0ZHU9 Cluster_714931 V1212772 S NA 0ZHU9 Cluster_569963 V1212777 K Transcriptional Regulator AraC Family COG2207 Cluster_436930 V1212785 BAS1404 M n-acetylmuramoyl-l-alanine amidase COG5632 Cluster_458853 V1212791 SARE_3718 S Terminase 11NCI Cluster_399993 V1212795 K HTH_XRE 0ZH40 Cluster_494588 V1212834 ECFA1 map02010 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates COG1122 Cluster_378820 V1212836 S NA 0ZHU9 Cluster_382312 V1212854 BL01893 T 2'-3'-cyclic nucleotide COG5324 Cluster_384096 V1212856 S NA 11UKT Cluster_391138 V1212869 S Lpxtg-motif cell wall anchor domain protein 0Y44U Cluster_454946 V1212870 APT map00230,map01100 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) COG0503 Cluster_724858 V1212872 S NA 0ZHU9 Cluster_394757 V1212876 BL00740 K transcriptional regulator 0XR9S Cluster_410669 V1212905 AMPC V Beta-lactamase COG1680 Cluster_465105 V1212918 TREC map00052,map00500,map01100 G trehalose-6-phosphate hydrolase (EC 3.2.1.93) COG0366 Cluster_687525 V1212942 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_512439 V1212952 S NA 0ZHU9 Cluster_748062 V1212955 S NA 0ZHU9 Cluster_438967 V1212969 S Membrane 123WC Cluster_507278 V1212973 S Gcn5-related n-acetyltransferase 1221G Cluster_528827 V1212984 GLPF G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) COG0580 Cluster_851710 V1212989 RPMH map03010 J 50S ribosomal protein l34 COG0230 Cluster_489608 V1213000 PEPC E aminopeptidase c COG3579 Cluster_526059 V1213002 S NA 0ZHU9 Cluster_678575 V1213003 S NA 0ZHU9 Cluster_551886 V1213019 S NA 0ZHU9 Cluster_465106 V1213026 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_636870 V1213038 NPR P pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_487251 V1213071 L terminase (Small subunit) COG3747 Cluster_721509 V1213075 S NA 0ZHU9 Cluster_702245 V1213079 K Transcriptional regulator 0Y1S3 Cluster_548980 V1213117 map00010,map00051,map00071,map00350,map00362,map00363,map00591,map00620,map00621,map00622,map00625,map00626,map00650,map00830,map00980,map00982,map01100,map01110,map01120 C Dehydrogenase COG1454 Cluster_512441 V1213126 S NA 0ZHU9 Cluster_512442 V1213130 MVAS map00072,map00280,map00650,map00900,map01100,map01110 I Hydroxymethylglutaryl-CoA synthase COG3425 Cluster_900513 V1213161 J EFG_IV COG0480 Cluster_579501 V1213163 NRDF map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_531613 V1213185 YJEM E Inner membrane transporter yjeM 174IZ@proNOG Cluster_573182 V1213275 SCPB K Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) COG1386 Cluster_576400 V1213288 TCTD map02020 T Two component transcriptional regulator (Winged helix family COG0745 Cluster_844027 V1213317 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_603156 V1213336 ACIN_0074 L Transposase COG3464 Cluster_796931 V1213346 S selenium-binding protein YdfZ 17N8C@proNOG Cluster_610434 V1213349 SRTA M (sortase) family COG3764 Cluster_839966 V1213359 S NA 0ZHU9 Cluster_621518 V1213371 GLNE O, T Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) COG1391 Cluster_820651 V1213387 GBRO_0040 L Transposase COG3464 Cluster_661259 V1213423 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_813076 V1213433 S NA 0ZHU9 Cluster_785177 V1213451 BGLF map00010,map00500,map00520,map02060 G pts system COG2190 Cluster_695888 V1213457 UDP map00230 S phosphorylase 11F11 Cluster_687527 V1213465 S NA 0XU1A Cluster_805058 V1213467 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_194414 V1213480 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_141989 V1213484 MALE map02010 G (ABC) transporter COG2182 Cluster_116283 V1213485 MALF map02010 P permease protein COG1175 Cluster_275054 V1213486 MALG map02010 P ABC transporter, permease COG3833 Cluster_252735 V1213489 DAGK I Diacylglycerol kinase COG1597 Cluster_37017 V1213492 MT2607 map00330,map00480,map01100,map01110 E decarboxylase COG1982 Cluster_434882 V1213493 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_408810 V1213494 S NA 0ZHU9 Cluster_55495 V1213495 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG2812 Cluster_134261 V1213497 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_47694 V1213498 M Cell surface protein 11GRZ Cluster_440938 V1213499 ATPH map00190,map00195,map01100 C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) COG0712 Cluster_545930 V1213504 RPSL map03010 J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) COG0048 Cluster_373560 V1213509 map00230,map00450,map00920,map01100,map01120 S (phospho)adenosine phosphosulfate reductase 17YKU@proNOG Cluster_338110 V1213511 YEAZ O Peptidase M22 Glycoprotease COG1214 Cluster_29442 V1213513 MAP2 map00500,map01100 G hydrolase family 65, central catalytic COG1554 Cluster_121387 V1213516 S Pfam:DUF1142 0YD7R Cluster_382313 V1213517 CUTC P copper homeostasis protein cutc COG3142 Cluster_164487 V1213519 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_246473 V1213527 YIHY S ribonuclease BN COG1295 Cluster_85534 V1213539 CELA map00010 G 6-phospho-beta-glucosidase (EC 3.2.1.86) COG2723 Cluster_265668 V1213546 K Transcriptional Regulator AraC Family COG2207 Cluster_233689 V1213552 LACC map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G tagatose-6-phosphate kinase COG1105 Cluster_69604 V1213556 MALL map00052,map00500,map01100 G trehalose-6-phosphate hydrolase (EC 3.2.1.93) COG0366 Cluster_603158 V1213558 S NA 0ZHU9 Cluster_57515 V1213559 OPPA E ABC transporter COG0747 Cluster_60647 V1213560 OPPA E ABC transporter COG0747 Cluster_430954 V1213588 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_473589 V1213590 NTD map00240 F Nucleoside deoxyribosyltransferase COG3613 Cluster_132636 V1213596 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_718179 V1213606 S NA 0ZHU9 Cluster_275055 V1213609 RSMI G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 Cluster_228937 V1213614 M Glycosyl transferase family 8 0Y03U Cluster_789183 V1213625 S NA 0ZHU9 Cluster_520362 V1213665 S NA 0ZHU9 Cluster_792966 V1213668 CSPA K Cold shock protein COG1278 Cluster_279054 V1213671 YBBP S TIGR00159 family COG1624 Cluster_428977 V1213693 HSDS1 V type I restriction-modification system COG0732 Cluster_394758 V1213694 LEXA K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) COG1974 Cluster_585929 V1213702 S NA 0ZHU9 Cluster_236086 V1213705 FBA map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01230 G Aldolase COG0191 Cluster_699159 V1213716 S NA 0ZHU9 Cluster_731429 V1213718 TRXA2 O Thioredoxin COG0526 Cluster_277693 V1213722 K transcriptional regulator COG1737 Cluster_711555 V1213739 S NA 0ZHU9 Cluster_758465 V1213740 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_563682 V1213742 S NA 17D58@proNOG Cluster_674123 V1213745 S Inherit from NOG: Toxin-antitoxin system, toxin component, RelE family 0Y0E0 Cluster_276144 V1021206 SCLAV_1731 S Protein of unknown function (DUF3097) 0XR3X Cluster_175181 V1021209 FADH map00633,map01120 C NADH flavin oxidoreductase NADH oxidase COG1902 Cluster_98324 V1021216 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_98855 V1021219 S NA 0YG6V Cluster_581978 V1021220 L resolvase COG1961 Cluster_346973 V1021222 M hydrolase, family 25 COG3757 Cluster_366687 V1021223 GLDA map02010 V ABC, transporter COG1131 Cluster_788390 V1021224 S NA 0ZHU9 Cluster_171001 V1021230 YDBM map00071,map00280,map00281,map00650,map00903,map01040,map01100,map01110 I acyl-CoA dehydrogenase 0XWKU Cluster_150301 V1021231 PRIA map03440 L Primosomal protein n' COG1198 Cluster_277457 V1021232 RARA L recombination factor protein RarA COG2256 Cluster_321095 V1021234 M Sortase family COG3764 Cluster_363226 V1021237 NHAA map00680 P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) COG3004 Cluster_624491 V1021238 WHIB3 K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) 11U54 Cluster_595263 V1021239 S NA 11M8V Cluster_578760 V1021241 RNPA J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) COG0594 Cluster_792156 V1021242 YIDD S Could be involved in insertion of integral membrane proteins into the membrane (By similarity) COG0759 Cluster_105705 V1021243 NIFJ map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map00910,map01100,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_101040 V1021252 L DNA helicase COG1112 Cluster_363227 V1021253 S NA 0XS0Q Cluster_269499 V1021257 YEGX M hydrolase, family 25 COG3757 Cluster_417561 V1021261 PNUC H Nicotinamide Mononucleotide Transporter COG3201 Cluster_100470 V1021262 KUP P Transport of potassium into the cell (By similarity) COG3158 Cluster_562962 V1021267 S Protein of unknown function (DUF3164) 11TRN Cluster_306287 V1021269 FTSE map02010 D Cell division ATP-binding protein ftsE COG2884 Cluster_413989 V1021273 TRAO S conjugative transposon protein TraO 0YB3M Cluster_394342 V1021274 TRAN S Conjugative transposon TraN protein 0XNQ2 Cluster_190610 V1021275 NUSA K Transcription elongation factor NusA COG0195 Cluster_128757 V1021279 ASPB K Transcriptional regulator COG1167 Cluster_102157 V1021280 ILVB map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E acetolactate synthase COG0028 Cluster_154316 V1021281 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_252485 V1021282 SCLAV_4612 D Chromosome partitioning ATPase COG0455 Cluster_816053 V1021283 ECHA3 map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120 I Enoyl-CoA hydratase COG1024 Cluster_887147 V1021284 THIS map04122 H Thiamine biosynthesis protein thiS 0ZZQD Cluster_136537 V1021285 THIO map00730 E glycine oxidase COG0665 Cluster_274820 V1021286 AASI_0159 L transposase is116 is110 is902 family COG3547 Cluster_343819 V1021287 RV2229C S Zn-ribbon protein possibly nucleic acid-binding COG1579 Cluster_181864 V1021288 ERYC E DegT DnrJ EryC1 StrS COG0399 Cluster_799899 V1021289 NQRD C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG1347 Cluster_403187 V1021290 NQRE C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG2209 Cluster_412068 V1021291 NQRF C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) COG2871 Cluster_406707 V1021292 P Chromate transport protein COG2059 Cluster_102708 V1021293 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_436500 V1021294 OMPH M outer membrane chaperone Skp (OmpH) 11GII Cluster_209200 V1021298 RV1480 S von Willebrand factor COG1721 Cluster_551261 V1021301 HSPR K merR family transcriptional Regulator COG0789 Cluster_115429 V1021302 GLPT map02020 G transporter COG2271 Cluster_591851 V1021304 SCLAV_4550 L UPF0102 protein COG0792 Cluster_609620 V1021305 GLTT E glutamate COG0786 Cluster_484464 V1021306 O Tryp_SPc 0YAAN Cluster_256227 V1021308 PPK2 map00190,map03018 L polyphosphate kinase 2 COG2326 Cluster_355032 V1021309 RLPA M rare lipoprotein A COG0797 Cluster_473119 V1021312 HYCH O formate hydrogenlyase maturation 11Q8X Cluster_235871 V1021317 AHCY map00270,map01100 H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) COG0499 Cluster_562963 V1021328 MT2225 S Membrane 124IY Cluster_366688 V1021329 YEGV G Kinase, PfkB family COG0524 Cluster_190611 V1021330 ADCA map02010 P periplasmic solute binding protein COG0803 Cluster_468886 V1021331 S Protein of unknown function (DUF3180) 11VVN Cluster_464687 V1021332 FOLK map00790,map01100 H 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase COG0801 Cluster_624492 V1021333 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_428588 V1021334 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_135736 V1021335 HEMG map00860,map01100,map01110 H Flavin containing amine oxidoreductase COG1232 Cluster_265427 V1021336 RLX U relaxase mobilization nuclease domain protein COG3843 Cluster_602317 V1021338 MOBC S mobilization protein 0YZDW Cluster_643896 V1021339 AROK map00400,map01100,map01110,map01230 E Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) COG0703 Cluster_174364 V1021340 S WD-40-like protein 0ZD2Z Cluster_217106 V1021341 map02010 V ABC-2 type transporter COG0842 Cluster_588479 V1021350 CMTB S esterase COG0627 Cluster_548281 V1021351 P transport system permease protein COG1173 Cluster_315019 V1021352 P transport system permease protein COG1173 Cluster_369973 V1021354 S hemolysin III COG1272 Cluster_106310 V1021356 S NA 0XRDA Cluster_364935 V1021357 CDHC S 3-keto-5-aminohexanoate cleavage enzyme COG3246 Cluster_118273 V1021358 GND map00030,map00480,map01100,map01110,map01120 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) COG0362 Cluster_220603 V1021359 BETA map00260,map01100 E Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) COG2303 Cluster_303369 V1021360 AARI_35290 L integrase catalytic COG2801 Cluster_107522 V1021362 MUTB map00280,map00630,map00640,map00720,map01100,map01120 I Methylmalonyl-coA mutase COG2185 Cluster_264081 V1021363 NADC map00760,map01100 H nicotinate-nucleotide pyrophosphorylase COG0157 Cluster_266742 V1021364 PURK map00230,map01100,map01110 F phosphoribosylaminoimidazole carboxylase atpase subunit COG0026 Cluster_156822 V1021365 S NA 11QWE Cluster_316581 V1021366 S Membrane COG1811 Cluster_454550 V1021368 S NA 0YG6V Cluster_635914 V1021370 YVDD L decarboxylase COG1611 Cluster_514523 V1021371 YQXD S UPF0178 protein COG1671 Cluster_479822 V1021372 ACCB map00061,map00253,map00620,map00640,map00720,map01100,map01110,map01120 I Acetyl-CoA carboxylase, biotin carboxyl carrier protein COG0511 Cluster_231052 V1021373 S NA 11IEF Cluster_595264 V1021375 S Membrane 0Y7CA Cluster_299212 V1021376 METX map00270,map00920,map01100 E Homoserine O-trans-acetylase COG2021 Cluster_181865 V1021377 IDSA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_253792 V1021378 M Glycosyl Transferase 11P3Q Cluster_486779 V1021379 M Polysaccharide Biosynthesis Protein COG2244 Cluster_691177 V1021380 S NA 0Z98M Cluster_754161 V1021382 SUHB map00521,map00562,map01100,map01110,map04070 G inositol monophosphatase COG0483 Cluster_660317 V1021384 TRXA O Thioredoxin COG0526 Cluster_862957 V1021386 PADR K Transcriptional regulator COG1695 Cluster_464688 V1021392 COBB map00860,map01100 H Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) COG1797 Cluster_358442 V1021393 MAQU_3187 L Integrase catalytic subunit COG4584 Cluster_322671 V1021394 LIN1243 S domain protein COG1235 Cluster_464689 V1021395 S NA 0ZI5S Cluster_109317 V1021397 S ragb susd domaiN-containing protein 0XQXG Cluster_161069 V1021400 AARI_34710 L Transposase for insertion sequence 11IYJ Cluster_484978 V1213825 U hydrolase, family 8 0Y1JM Cluster_851721 V1213826 S NA 0ZHU9 Cluster_721518 V1213828 S NA 0ZHU9 Cluster_766182 V1213829 S NA 0ZHU9 Cluster_718182 V1213858 S NA 0ZHU9 Cluster_582742 V1213874 MEPR K Transcriptional regulator 121PJ Cluster_744711 V1213884 S NA 0ZHU9 Cluster_576401 V1213901 S NA 0ZHU9 Cluster_340998 V1213911 GBS0396 map03070 U Pfam:TraG COG3505 Cluster_678579 V1213933 S NA 0ZHU9 Cluster_748070 V1213936 S NA 0ZHU9 Cluster_800843 V1213943 S NA 0ZHU9 Cluster_828496 V1213963 S NA 0ZHU9 Cluster_515146 V1213966 HIPMA_0065 L Transposase COG3328 Cluster_800844 V1213984 S NA 0ZHU9 Cluster_702249 V1213987 S NA 0ZHU9 Cluster_792968 V1213991 S NA 0ZHU9 Cluster_417935 V1213993 S NA 0ZHU9 Cluster_820663 V1214025 S NA 0ZHU9 Cluster_816869 V1214027 PNCA map00760,map01100 Q isochorismatase COG1335 Cluster_596081 V1214037 S Protein of unknown function (DUF1304) 0XV9E Cluster_844041 V1214044 S NA 0ZHU9 Cluster_644775 V1214046 S NA 0ZHU9 Cluster_603159 V1214049 S NA 0ZHU9 Cluster_781055 V1214064 S NA 0ZHU9 Cluster_446977 V1214076 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_526061 V1214090 SP_0161 K, T lytTr DNA-binding domain protein COG3279 Cluster_425153 V1214107 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_528830 V1214156 S NA 0ZHU9 Cluster_450973 V1214169 S NA 0ZHU9 Cluster_452925 V1214172 CADA P heavy metal translocating p-type ATPase COG2217 Cluster_800850 V1214196 S NA 0ZHU9 Cluster_781060 V1214211 S NA 0ZHU9 Cluster_900536 V1214250 S NA 0ZHU9 Cluster_699163 V1214253 S NA 0ZHU9 Cluster_859497 V1214259 ARLR map02020 T response regulator COG0745 Cluster_537301 V1214261 S NA 11GVV Cluster_744717 V1214318 S NA 0ZHU9 Cluster_758470 V1214414 S NA 17D58@proNOG Cluster_542979 V1214419 K Transcriptional regulator 0Y1S3 Cluster_762227 V1214465 S NA 0ZHU9 Cluster_702251 V1214479 S NA 0ZHU9 Cluster_579504 V1214488 PCKA map00010,map00020,map00620,map00710,map01100,map01110,map01120 C phosphoenolpyruvate carboxykinase 0XT66 Cluster_606766 V1214504 S NA 0ZHU9 Cluster_792973 V1214508 S NA 0ZHU9 Cluster_592598 V1214522 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_603164 V1214546 OGT L Methyltransferase COG0350 Cluster_836102 V1214577 S Gcn5-related n-acetyltransferase 1221G Cluster_892100 V1214581 S NA 0ZHU9 Cluster_629031 V1214583 L Nudix family COG0494 Cluster_728134 V1214599 S NA 0ZHU9 Cluster_669744 V1214644 MNAA map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_792976 V1214670 S NA 0ZHU9 Cluster_769944 V1214675 YJHA S Endonuclease Exonuclease phosphatase 0XNVA Cluster_395 V1214686 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_762231 V1214703 S NA 0ZHU9 Cluster_531614 V1214716 S NA 0ZHU9 Cluster_632848 V1214737 S NA 0ZHU9 Cluster_494594 V1214742 S NA 0ZHU9 Cluster_744720 V1214745 S NA 0ZHU9 Cluster_629032 V1214746 S NA 0ZHU9 Cluster_482652 V1214754 S NA 0ZHU9 Cluster_751495 V1214807 S NA 0ZHU9 Cluster_721523 V1214832 S NA 0ZHU9 Cluster_384097 V1214854 COBC map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_844050 V1214862 S NA 0ZHU9 Cluster_596084 V1214879 S NA 0ZHU9 Cluster_644777 V1214895 S NA 0ZHU9 Cluster_414352 V1214909 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_813096 V1214930 S NA 0ZHU9 Cluster_463022 V1214971 S NA 0ZP3E Cluster_839977 V1214994 S NA 17D58@proNOG Cluster_648823 V1215036 CLPC O ATP-dependent Clp protease ATP-binding subunit COG0542 Cluster_683107 V1215046 S NA 0ZHU9 Cluster_728137 V1215052 S NA 0ZHU9 Cluster_573183 V1215083 DEXB map00052,map00500,map01100 G alpha amylase, catalytic region COG0366 Cluster_569968 V1215124 M Cell surface protein 11GRZ Cluster_569969 V1215127 S NA 0ZHU9 Cluster_582745 V1215133 BL02952 S Membrane COG1434 Cluster_711566 V1215157 EF0078 map00051,map00520,map01100,map02060 G PTS System COG3715 Cluster_526062 V1215252 S NA 0ZHU9 Cluster_652914 V1215261 S NA 0ZHU9 Cluster_475727 V1215263 L Transposase 11M0T Cluster_131120 V1215286 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_168525 V1215290 S Acyltransferase family 11XA1 Cluster_805080 V1215291 S NA 0ZHU9 Cluster_692077 V1215300 RPLW map03010 J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) COG0089 Cluster_171965 V1215301 PURB map00230,map00250,map00362,map01100,map01110,map01120 F adenylosuccinate lyase COG0015 Cluster_548988 V1215303 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_289975 V1215312 AMAA map00360 E amidohydrolase COG1473 Cluster_243875 V1215327 4HBD map00650 C NAD-dependent 4-hydroxybutyrate dehydrogenase COG1454 Cluster_251525 V1215328 RODA map00550,map04112 D cell cycle protein COG0772 Cluster_785198 V1215330 GLF M udp-galactopyranose mutase COG0562 Cluster_357077 V1215331 M Glycosyl transferase family 2 COG0463 Cluster_603167 V1215335 S NA 0ZHU9 Cluster_606769 V1215337 S NA 0ZHU9 Cluster_687545 V1215340 MJLS_1669 L transposase, IS3 IS911 family protein COG2963 Cluster_640916 V1215341 S NA 0ZHU9 Cluster_280358 V1215344 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_407057 V1215350 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_296771 V1215353 DPRE1 C FAD linked oxidase domain protein COG0277 Cluster_329081 V1215363 S ApbE family 11H27 Cluster_315324 V1215368 S PAP2 superfamily 0XZ0P Cluster_326020 V1215374 DPPD E, P (ABC) transporter COG0444 Cluster_333532 V1215379 TGT J Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COG0343 Cluster_844055 V1215383 S NA 0YXS4 Cluster_589234 V1215386 U Type IV secretory pathway VirD4 COG3505 Cluster_523140 V1215387 SCLAV_1560 map02010 P ABC transporter COG1122 Cluster_758477 V1215388 BDP_1102 V abc transporter COG1136 Cluster_339546 V1215389 LYTR2 K TRANSCRIPTIONal COG1316 Cluster_875891 V1215392 YHAO L DNA repair exonuclease COG0420 Cluster_463023 V1215395 G glycoside hydrolase, family COG1626 Cluster_347311 V1215397 UDP map00230 S phosphorylase 11F11 Cluster_507279 V1215399 S NA 0ZHU9 Cluster_355387 V1215404 S NA 0ZHU9 Cluster_434883 V1215409 DARB map00061,map01100 I synthase III COG0332 Cluster_368612 V1215411 AMYE map02010 G solute-binding protein COG1653 Cluster_399994 V1215416 PIP S domain protein COG1511 Cluster_699172 V1215417 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_526063 V1215419 TATD L Hydrolase, tatD family COG0084 Cluster_705334 V1215420 J sua5 ycio yrdc ywlc family protein COG0009 Cluster_421508 V1215421 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_392952 V1215428 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_585931 V1215432 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_425154 V1215433 MT3543 S NA 11ISP Cluster_396545 V1215434 PIP map00330 L Prolyl aminopeptidase COG0596 Cluster_454949 V1215435 CSN1 V CRISPR-associated 10TRZ Cluster_896274 V1215438 S NA 0XY3U Cluster_408811 V1215452 RNC map03008,map05205 K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) COG0571 Cluster_484981 V1215455 DPS P During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction COG0783 Cluster_809121 V1215458 S NA 17D58@proNOG Cluster_416136 V1215460 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_417936 V1215462 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_523141 V1215463 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_423366 V1215474 S NA 126VW Cluster_428979 V1215485 V ABC, transporter COG0577 Cluster_428980 V1215486 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_428981 V1215488 GLF M udp-galactopyranose mutase COG0562 Cluster_434884 V1215493 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_517817 V1215494 PSTS2 map02010,map02020,map05152 P Phosphate-binding protein COG0226 Cluster_526064 V1215499 LYSC map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Aspartokinase COG0527 Cluster_440939 V1215500 KUP P Transport of potassium into the cell (By similarity) COG3158 Cluster_892120 V1215505 S NA 0ZCAU Cluster_440940 V1215507 MALQ map00500,map01100 G 4-alpha-glucanotransferase COG1640 Cluster_683113 V1215508 S radical SAM domain protein COG0641 Cluster_465107 V1215509 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_482654 V1215518 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_450975 V1215524 XERD L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_737997 V1215531 S Toxin-antitoxin system, toxin component, HicA family 126G5 Cluster_836114 V1215534 DPPD map02010 S ABC transporter COG1123 Cluster_460903 V1215538 S domain protein 0XNZW Cluster_863857 V1215541 S NA 0ZHU9 Cluster_480343 V1215547 S NA 0YNFS Cluster_582747 V1215554 M Transferase COG1216 Cluster_467191 V1215559 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins COG0706 Cluster_494595 V1215562 PURA map00230,map00250,map01100 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis COG0104 Cluster_471476 V1215573 G Aamy_C COG1523 Cluster_475728 V1215581 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_480344 V1215590 PTSG map00010,map00500,map00520,map02060 G PTS System COG1264 Cluster_652915 V1215593 MURF map00300,map00550,map01100 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) COG0770 Cluster_482655 V1215595 MRCB map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_504693 V1215597 RIHB map00230,map00240,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_484982 V1215600 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_669747 V1215603 S NA 0ZHU9 Cluster_545932 V1215607 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_489614 V1215608 PEPD E Dipeptidase COG4690 Cluster_769950 V1215610 GLUQ map00860,map00970,map01100,map01110 J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) COG0008 Cluster_494596 V1215613 ARGG map00250,map00330,map01100,map01110,map01230 E Citrulline--aspartate ligase COG0137 Cluster_557667 V1215626 FOLB map00790,map01100 H dihydroneopterin aldolase COG1539 Cluster_705336 V1215629 S ApbE family 11H27 Cluster_504694 V1215630 RND J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) COG0349 Cluster_504695 V1215636 UGPC map02010 G (ABC) transporter COG3839 Cluster_507280 V1215637 COBN map00860,map01100 H cobaltochelatase, cobn subunit COG1429 Cluster_563689 V1215640 UGD map00040,map00053,map00500,map00520,map01100,map01110 M UDP-glucose 6-dehydrogenase COG1004 Cluster_548989 V1215641 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_509865 V1215645 HOM map00260,map00270,map00300,map01100,map01110,map01120,map01230 E homoserine dehydrogenase COG0460 Cluster_512445 V1215646 DPPB map02010 P ABC transporter (Permease) COG0601 Cluster_515149 V1215650 FLUTA_0256 L Transposase COG3464 Cluster_754953 V1215653 ASPA map00250,map00910,map01100 E Aspartate ammonia-lyase COG1027 Cluster_683114 V1215665 S integral membrane protein 0XS1S Cluster_526065 V1215669 U relaxase mobilization nuclease domain protein COG3843 Cluster_526066 V1215672 S NA 0ZTYV Cluster_526067 V1215673 M Inherit from NOG: domain protein 18B9F@proNOG Cluster_741422 V1215674 S NA 11H00 Cluster_531615 V1215693 BT_0485 L transposase is116 is110 is902 family COG3547 Cluster_531616 V1215697 GLGB map00500,map01100,map01110 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) COG0296 Cluster_531617 V1215699 TIG O Peptidyl-prolyl cis-trans isomerase COG0545 Cluster_632854 V1215701 AMTB P ammonium transporter 0XNMH Cluster_534402 V1215703 M Inherit from NOG: domain protein 18B9F@proNOG Cluster_537303 V1215708 PBP2B map00550,map01100 M penicillin-binding protein COG0768 Cluster_540106 V1215709 map02010 P ABC transporter COG1122 Cluster_542982 V1215714 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_542983 V1215719 COAA map00770,map01100 H pantothenic acid kinase COG1072 Cluster_816892 V1215727 S NA 185WP@proNOG Cluster_625307 V1215728 ISPF map00900,map01100,map01110 I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) COG0245 Cluster_551888 V1215734 PURM map00230,map01100,map01110 F phosphoribosylaminoimidazole synthetase COG0150 Cluster_900564 V1215737 NOX map00190 P pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_606772 V1215742 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_705338 V1215748 LDTA S ErfK YbiS YcfS YnhG COG1376 Cluster_851739 V1215751 TRAN S Conjugative transposon TraN protein 0XNQ2 Cluster_557669 V1215756 MUTT1 L NUDIX hydrolase COG0494 Cluster_669748 V1215764 VEX1 V ABC transporter, permease COG0577 Cluster_563691 V1215765 AGCS E amino acid carrier protein COG1115 Cluster_563692 V1215766 TYRA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydrogenase COG0287 Cluster_731447 V1215776 RPLQ map03010 J 50S ribosomal protein l17 COG0203 Cluster_566885 V1215780 NOX map00190 P pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_569970 V1215783 S NA 0YESD Cluster_702257 V1215786 COMEC S ComEC Rec2-like protein COG0658 Cluster_762243 V1215788 S Inherit from NOG: Methyltransferase 0XSGP Cluster_576403 V1215792 S NA 0ZAU4 Cluster_687548 V1215794 RARA L recombination factor protein RarA COG2256 Cluster_576404 V1215799 DPPB map02010 P ABC transporter (Permease) COG0601 Cluster_576405 V1215800 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG0194 Cluster_219434 V1021403 FRUK-1 map00051 G 1-phosphofructokinase COG1105 Cluster_346974 V1021405 CSP1 M LGFP repeat COG5479 Cluster_110595 V1021406 SASC S surface protein 11FPX Cluster_426667 V1021407 S NA 126XC Cluster_147944 V1021408 L Inherit from COG: transposase COG3385 Cluster_525413 V1021409 SCRB map00052,map00500,map01100 G hydrolase COG1621 Cluster_496544 V1021410 SCRA map00500,map02060 G PTS system COG2190 Cluster_232205 V1021411 S NA 0Z51W Cluster_562964 V1021412 S NA 0ZMA4 Cluster_511884 V1021415 RPLI map03010 J Binds to the 23S rRNA (By similarity) COG0359 Cluster_227538 V1021417 P abc transporter atp-binding protein COG1116 Cluster_282845 V1021418 COMEA L Competence protein COG1555 Cluster_159370 V1021420 AARI_34710 L Transposase for insertion sequence 11IYJ Cluster_446572 V1021421 ATPH map00190,map00195,map01100 C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) COG0712 Cluster_530984 V1021422 S -acetyltransferase 0XYCF Cluster_788391 V1021423 S Protein of unknown function (DUF2582) 0XWWH Cluster_355033 V1021425 PSD map00564,map01100 I Phosphatidylserine decarboxylase proenzyme COG0688 Cluster_412069 V1021426 S conjugative transposon protein TraO 0YB3M Cluster_419281 V1021427 TRAN_2 S Conjugative transposon TraN protein 0XNQ2 Cluster_784344 V1021431 S NA 0XZ3Z Cluster_226421 V1021432 APEB E M18 family aminopeptidase COG1362 Cluster_202719 V1021433 PILB map03070 U type ii secretion system protein e COG2804 Cluster_160249 V1021434 S Membrane COG3949 Cluster_111935 V1021435 S NA 11TF5 Cluster_257470 V1021436 PHOH T Phoh family COG1702 Cluster_280105 V1021437 PHAB map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120 I Enoyl-CoA hydratase 0XTHX Cluster_336280 V1021440 L TatD family COG0084 Cluster_112632 V1021441 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_188003 V1021442 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_380172 V1021446 FLDA map00910,map01120 C Low-potential electron donor to a number of redox enzymes (By similarity) COG0716 Cluster_315020 V1021447 S Family of unknown function (DUF490) 0Z0C5 Cluster_406708 V1021448 M Outer membrane protein, OMP85 family 0XNPU Cluster_113359 V1021449 NIFJ map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map00910,map01100,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_113360 V1021450 S integral membrane protein 11VP2 Cluster_438550 V1021451 S NA 0YNYF Cluster_757734 V1021452 S NA 126R7 Cluster_113361 V1021453 map01054 Q synthetase COG1020 Cluster_195123 V1021455 HEMB map00860,map01100,map01110 H delta-aminolevulinic acid dehydratase COG0113 Cluster_887149 V1021456 HEMD map00860,map01100,map01110 H synthase COG1587 Cluster_385505 V1021457 GLTD map00250,map00910,map01100,map01110,map01120,map01230 E Glutamate synthase COG0493 Cluster_340736 V1021458 NIRK map00910,map01120 Q nitrite reductase COG2132 Cluster_120483 V1021468 V ABC transporter COG1132 Cluster_686557 V1021470 ECOLC_0728 L Transposase is3 is911 COG2963 Cluster_270818 V1021471 AVIN_16550 L Transposase COG2801 Cluster_168375 V1021474 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_698510 V1021475 M Glycosyl transferase, family 2 16QVP@proNOG Cluster_569251 V1021476 CSEE S NA 0XUV8 Cluster_276145 V1021477 RLUD2 J pseudouridine synthase COG0564 Cluster_396211 V1021478 RBSK map00030 G ribokinase COG0524 Cluster_199688 V1021479 map02010 P abc transporter COG1131 Cluster_210290 V1021480 SLGD_00086 S Ser Thr phosphatase family protein COG1409 Cluster_325727 V1021481 L DNA methylase n-4 n-6 domain protein COG0863 Cluster_595265 V1021482 RPLN map03010 J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) COG0093 Cluster_430574 V1021483 SIGM K RNA polymerase COG1595 Cluster_346975 V1021485 S Rhodanese-like domain 11QSF Cluster_528239 V1021487 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0847 Cluster_134933 V1021488 SP_1221 V restriction 0XQ8K Cluster_424782 V1021489 K Tetr family transcriptional regulator 11ZIV Cluster_602318 V1021490 S NA 11Z5A Cluster_292370 V1021494 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_322672 V1021495 YRBE Q ABC superfamily ATP binding cassette transporter permease protein COG0767 Cluster_260125 V1021496 S NA 0XZ8I Cluster_602319 V1021497 S rhodanese-like protein 0ZX1Q Cluster_156823 V1021499 SPL M NlpC/P60 family COG0791 Cluster_366689 V1021500 YDHK S (LipO)protein 11PEU Cluster_664520 V1021501 YEED O redox protein, regulator of disulfide bond formation COG0425 Cluster_299213 V1021502 S Inherit from NOG: antigen PG97 COG4886 Cluster_117589 V1021503 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_525414 V1021504 P transport protein COG2985 Cluster_390812 V1021505 S NA 0ZHU9 Cluster_244924 V1021506 S ErfK ybiS ycfS ynhG family protein 0ZJ65 Cluster_569252 V1021511 S NA 12B7K Cluster_311980 V1021512 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_639976 V1021513 K ArsR family transcriptional regulator COG0640 Cluster_128079 V1021514 SULP P sulfate transporter COG0659 Cluster_466707 V1021517 TRML map04122 J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) COG0219 Cluster_140374 V1021523 UGD map00040,map00053,map00500,map00520,map01100,map01110 M UDP-glucose 6-dehydrogenase COG1004 Cluster_204850 V1021525 CYDD map02010 V ABC, transporter COG4988 Cluster_635915 V1021526 YJJK S ABC transporter, ATP-binding protein COG0488 Cluster_432574 V1021527 map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_539528 V1021529 NDK map00230,map00240,map01100,map01110 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) COG0105 Cluster_462587 V1021530 S Membrane 12317 Cluster_306288 V1021531 L Dna topoisomerase COG0550 Cluster_430575 V1021532 MAF D MAF-like protein COG0424 Cluster_252486 V1021534 S NA 11R7X Cluster_345416 V1021535 V ABC transporter COG1136 Cluster_345417 V1021537 S abc transporter atp-binding protein 11HXT Cluster_373254 V1021539 PURE map00230,map01100,map01110 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) COG0041 Cluster_145578 V1021540 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_296560 V1021541 L DNA Methylase COG2189 Cluster_264082 V1021545 L UvrD REP helicase COG1074 Cluster_121999 V1021546 S NA 0Z4Z7 Cluster_536673 V1021548 S NA 122DJ Cluster_473120 V1021550 S NA 12D6S Cluster_656169 V1021552 S Toxin-antitoxin system, toxin component, RelE family 122IP Cluster_260126 V1021555 ADCA map02010 P periplasmic solute binding protein COG0803 Cluster_122703 V1021556 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_210291 V1021557 map00860,map01100 H Precorrin-6y C5,15-methyltransferase COG2242 Cluster_243646 V1021564 TIG O Peptidyl-prolyl cis-trans isomerase COG0545 Cluster_123339 V1021565 YPWA E carboxy-peptidase COG2317 Cluster_462588 V1021566 L helicase COG1061 Cluster_727357 V1021568 S Inherit from COG: Virulence-associated protein e COG5545 Cluster_484465 V1021570 ARGB map00330,map01100,map01110,map01210,map01230 E nag kinase COG0548 Cluster_299214 V1021571 ARGD map00300,map00330,map01100,map01110,map01120,map01210,map01230 E acetylornithine aminotransferase COG4992 Cluster_152736 V1021572 S NA 0Z9TI Cluster_152737 V1021573 F Uracil permease COG2233 Cluster_225294 V1021574 V Type I restriction modification DNA specificity domain 0ZKBR Cluster_609621 V1021575 RPSP map03010 J 30s ribosomal protein S16 COG0228 Cluster_123340 V1021576 S NA 11JP6 Cluster_545239 V1021577 S NA 0YIEB Cluster_740683 V1021581 ZNTA P ATPase (EC 3.6.3.-) COG2217 Cluster_193277 V1021582 S Acyl-transferase 128XF Cluster_819696 V1021584 S NA 0ZHU9 Cluster_211387 V1021589 GND map00030,map00480,map01100,map01110,map01120 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) COG0362 Cluster_257471 V1021590 GLUQ map00860,map00970,map01100,map01110 J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) COG0008 Cluster_156824 V1021597 ORF028 S NA 0ZZ9R Cluster_125293 V1021599 EXPZ S ABC transporter, ATP-binding protein COG0488 Cluster_276146 V1021600 RRMJ J Hemolysin A COG1189 Cluster_629033 V1215805 XPT map00230,map01100,map01110 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) COG0503 Cluster_576406 V1215806 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_579508 V1215808 MOXR S Atpase associated with various cellular activities aaa_3 COG0714 Cluster_576407 V1215810 PEPN map00480,map01100 E aminopeptidase N COG0308 Cluster_579509 V1215812 RV1825 S Bacterial protein of unknown function (DUF881) COG3879 Cluster_661267 V1215813 YFMR S abc transporter COG0488 Cluster_599600 V1215816 S NA 11ZHA Cluster_582748 V1215819 S Relaxase mobilization nuclease 0Y9PG Cluster_585933 V1215822 ADH map00051,map00363,map00591,map00625,map00650,map01100,map01120 C alcohol dehydrogenase COG1454 Cluster_734667 V1215823 STSB P Binding-protein-dependent transport systems, inner membrane component COG0601 Cluster_585934 V1215826 METE map00270,map00450,map01100,map01110,map01230 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) COG0620 Cluster_585935 V1215830 SOJ D Chromosome Partitioning Protein COG1192 Cluster_589236 V1215834 P binding-protein-dependent transport systems inner membrane Component COG4986 Cluster_589237 V1215836 CAS3 L CRISPR-associated helicase, cas3 COG1203 Cluster_705339 V1215837 MIDI_00056 L Transposase 0YEAS Cluster_589238 V1215838 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_589239 V1215839 L Integrase, catalytic region COG2801 Cluster_592602 V1215842 MT1293 map00350,map00362,map00627,map00642,map00903,map01120 I Acyl-transferase COG1835 Cluster_592603 V1215843 NDVA2 V ABC transporter, ATP-binding protein COG1132 Cluster_592604 V1215847 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_592605 V1215848 THIO map00730 E glycine oxidase COG0665 Cluster_596087 V1215850 S NA 11SYG Cluster_721526 V1215855 S NA 0ZTGB Cluster_702258 V1215860 PURF map00230,map00250,map01100,map01110 F glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_855515 V1215861 VICX map03013 S domain protein COG1235 Cluster_610441 V1215875 V ATPase associated with various cellular activities aaa_5 COG1401 Cluster_606774 V1215876 NQRE C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG2209 Cluster_610442 V1215877 C domain protein COG0426 Cluster_606775 V1215878 L Resolvase COG1961 Cluster_610443 V1215884 L type iii restriction protein res subunit COG3886 Cluster_610444 V1215888 RARA L recombination factor protein RarA COG2256 Cluster_614086 V1215897 DAPB map00300,map01100,map01110,map01120,map01230 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) COG0289 Cluster_621524 V1215901 HELY L helicase COG4581 Cluster_758480 V1215902 DCIAE E Extracellular solute-binding protein, family 5 COG0747 Cluster_617857 V1215903 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_644778 V1215904 CPDB map00230,map00240,map00760,map01100,map01110 F 5-nucleotidase COG0737 Cluster_621525 V1215906 L site-specific recombinase, phage integrase family 0ZJK4 Cluster_621526 V1215910 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_625309 V1215917 TRAA L TrwC relaxase COG0507 Cluster_629035 V1215923 S Rib/alpha-like repeat 10008 Cluster_625310 V1215924 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_629036 V1215928 map00270,map00920,map01100,map01120,map01230 E serine acetyltransferase COG1045 Cluster_687551 V1215929 S NA 0YF67 Cluster_741423 V1215930 HISE2 E Hydrolase COG0637 Cluster_632855 V1215932 NRDF map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_632856 V1215933 YQEY S gatB Yqey COG1610 Cluster_632857 V1215934 NUOE map00190,map00910,map01100 C NADH dehydrogenase (Ubiquinone), 24 kDa subunit COG1905 Cluster_636884 V1215940 THIE map00730,map01100 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) COG0422 Cluster_665440 V1215947 S HipA domain protein COG3550 Cluster_711569 V1215950 MURE map00300,map00550 M mur ligase COG0769 Cluster_648826 V1215957 DINF V Mate efflux family protein COG0534 Cluster_762244 V1215959 PURC map00230,map01100,map01110 F SAICAR synthetase COG0152 Cluster_648827 V1215962 S phosphate 0XP49 Cluster_820693 V1215963 ATPH map00190,map00195,map01100 C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) COG0712 Cluster_648828 V1215965 TYRA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydrogenase COG0287 Cluster_766215 V1215971 NTPJ P Potassium uptake protein COG0168 Cluster_652920 V1215976 S (LipO)protein 0YDWI Cluster_652921 V1215977 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_789203 V1215980 PKNB T Serine Threonine protein kinase COG0515 Cluster_661268 V1215981 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_828513 V1215991 GSHA map00480,map01100 H glutamate--cysteine ligase COG3572 Cluster_702259 V1215995 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_665442 V1216000 MAEB map00620,map00710,map01100,map01120,map02020 C Malic enzyme COG0281 Cluster_669750 V1216003 GLGC map00500,map00520,map01100,map01110 G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) COG0448 Cluster_674140 V1216005 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_674141 V1216010 ILVB map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E Acetolactate synthase, large subunit COG0028 Cluster_678589 V1216015 F cytosine purines uracil thiamine allantoin COG1457 Cluster_678590 V1216018 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_678591 V1216019 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_683116 V1216020 SCLAV_3021 S (twin-arginine translocation) pathway signal COG3211 Cluster_683117 V1216023 S NA 11NI8 Cluster_683118 V1216025 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_687553 V1216029 LDH map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120 C L-Lactate dehydrogenase COG0039 Cluster_687554 V1216032 COBW S Cobalamin synthesis protein cobW C-terminal domain COG0523 Cluster_687555 V1216034 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_692082 V1216038 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_102249 V1216040 N, U spore coat assembly protein SafA COG1388 Cluster_26031 V1216041 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG2812 Cluster_115556 V1216042 P Chloride channel COG0038 Cluster_83005 V1216043 GATA map00970,map01100 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) COG0154 Cluster_300819 V1216044 YLME F alanine racemase domain protein COG0325 Cluster_187314 V1216045 GLUQ map00860,map00970,map01100,map01110 J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) COG0008 Cluster_110054 V1216046 MURE map00300,map00550 M mur ligase COG0769 Cluster_81748 V1216047 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_56498 V1216049 S integral membrane protein 0XS1S Cluster_250305 V1216051 RV1825 S Bacterial protein of unknown function (DUF881) COG3879 Cluster_179495 V1216052 GLUD map02010 E amino acid AbC transporter COG0765 Cluster_32077 V1216055 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_112762 V1216056 VEX3 V abc transporter permease protein COG0577 Cluster_116284 V1216058 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_62368 V1216059 GSIA map02010 S ABC transporter COG1123 Cluster_8113 V1216060 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_49794 V1216062 M Inherit from NOG: Lpxtg-motif cell wall anchor domain protein 0Y6CS Cluster_160372 V1216063 M Sortase family COG3764 Cluster_378821 V1216064 S NA 11QRM Cluster_21000 V1216065 S NA 11QZ9 Cluster_398271 V1216066 S NA 11WG4 Cluster_25115 V1216067 PARE L DNA topoisomerase IV subunit B COG0187 Cluster_21222 V1216069 T Histidine kinase COG4585 Cluster_6505 V1216070 RV3193C S UPF0182 protein COG1615 Cluster_27362 V1216071 METE map00270,map00450,map01100,map01110,map01230 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) COG0620 Cluster_8921 V1216072 GLNE O, T Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) COG1391 Cluster_355388 V1216073 PYRE map00240,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_484983 V1216074 HSDS V restriction -modification system COG0732 Cluster_21309 V1216075 S NA 0Y9Z0 Cluster_744735 V1216076 SP_0122 S UPF0356 protein COG5503 Cluster_185556 V1216077 S Auxin Efflux Carrier COG0679 Cluster_777342 V1216078 K Transcriptional regulator 0XUP9 Cluster_49367 V1216080 S atpase involved in dna repair 0XRFS Cluster_347312 V1216081 SURB S G5 domain protein 0ZVV3 Cluster_205040 V1216082 S ApbE family 11H27 Cluster_136682 V1216083 Y2367 P integral membrane protein COG4393 Cluster_389405 V1216084 S FMN_bind 12BR0 Cluster_189014 V1216085 NRDF map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_31504 V1216086 NRDE map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_617858 V1216087 S NA 126R7 Cluster_467193 V1216088 S GtrA-like protein 11U0Q Cluster_7444 V1216089 S NA 12BGB Cluster_398272 V1216090 AASI_0458 S WbqC-like 0ZW99 Cluster_193477 V1216091 S Protein of unknown function (DUF1189) 0Y1IJ Cluster_357078 V1216093 M Ompa motb domain protein COG2885 Cluster_24466 V1216094 IRP P tonB-dependent Receptor COG1629 Cluster_280359 V1216096 LICD3 M licD family COG3475 Cluster_265670 V1216097 SAGE S CAAX amino protease family protein 0XUJM Cluster_102250 V1216098 BVU_1425 L Transposase COG3039 Cluster_242523 V1216099 P ABC 3 transport family protein COG1108 Cluster_242524 V1216100 CPSY K Transcriptional regulator COG0583 Cluster_358752 V1216102 S NA 12BYI Cluster_30714 V1216103 S p-loop domain protein COG4928 Cluster_4558 V1216104 SP_1222 V restriction endonuclease 0ZVJ1 Cluster_218459 V1216105 S Type II DNA modification methyltransferase 0ZM02 Cluster_62369 V1216106 NADE map00760,map01100 H Nad synthetase COG0388 Cluster_182983 V1216108 TILS map00230,map00983,map01100,map01110 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) COG0037 Cluster_70888 V1216109 SSCG_00971 S integral membrane transport protein 0XP2U Cluster_124090 V1216110 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_46725 V1216111 RGPF M Rhamnan synthesis protein F COG3754 Cluster_25497 V1216112 MRCB map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_176948 V1216115 L Reverse transcriptase COG3344 Cluster_276389 V1216123 SCLAV_2148 S NA 0XNX0 Cluster_396546 V1216124 S NA 0ZG83 Cluster_557670 V1216130 S NA 0ZAU4 Cluster_269732 V1216131 S NA 11NRA Cluster_161202 V1216135 L Integrase COG0582 Cluster_203966 V1216137 DPPC map02010 P ABC transporter (Permease) COG1173 Cluster_72480 V1216138 DPPA map02010 E ABC transporter substrate-binding protein COG4166 Cluster_499764 V1216139 AROQ map00400,map01100,map01110,map01230 E Catalyzes a trans-dehydration via an enolate intermediate (By similarity) COG0757 Cluster_61270 V1216140 AROB map00400,map01100,map01110,map01230 E 3-dehydroquinate synthase COG0703 Cluster_12711 V1216141 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_47286 V1216142 TYPA T gtp-binding protein typa COG1217 Cluster_70889 V1216143 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_188172 V1216144 COMGB U Competence protein COG1459 Cluster_106411 V1216145 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_300820 V1216146 S NA 101UU Cluster_36263 V1216148 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_156099 V1216149 FRDB map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020 C succinate dehydrogenase COG0479 Cluster_302215 V1216150 RSME S Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) COG1385 Cluster_131890 V1216151 PHOH T Phoh family COG1702 Cluster_82539 V1216152 GLDE P CBS domain containing protein COG1253 Cluster_16668 V1216154 S domain protein 0XPXI Cluster_150444 V1216155 S Cell surface-anchored protein 1005T Cluster_335034 V1216157 YJBH Q Dithiol-disulfide isomerase COG2761 Cluster_809124 V1216158 FLUTA_0256 L Transposase COG3464 Cluster_375277 V1216159 YADS S Membrane COG2860 Cluster_34909 V1216160 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_95699 V1216161 L Domain protein COG0507 Cluster_347313 V1216162 ORN map03008 A 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) COG1949 Cluster_365289 V1216163 SUA5 J sua5 ycio yrdc ywlc family protein COG0009 Cluster_252736 V1216164 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_226 V1216165 S NA 101UU Cluster_394759 V1216166 RPLY map03010 J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) COG1825 Cluster_38832 V1216167 FADD15 map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG1022 Cluster_610446 V1216169 S interferon-induced transmembrane protein 121MN Cluster_54998 V1216171 M Cell wall anchor domain protein 11Q8J Cluster_4217 V1216173 UVRD2 map03420,map03430 L helicase COG0210 Cluster_60648 V1216174 M Sulfatase COG1368 Cluster_124744 V1216175 L Integrase 0YTFQ Cluster_228938 V1216176 L site-specific recombinase, phage integrase family 0ZF8H Cluster_67888 V1216178 S NA 0YRIH Cluster_33523 V1216185 S NA 11VT6 Cluster_408812 V1216187 GNTK map00030,map00400,map01100,map01110,map01120,map01230 G carbohydrate kinase, thermoresistant glucokinase family COG3265 Cluster_26258 V1216188 map00550,map01100 M glycosyl transferase, family 51 COG0744 Cluster_255205 V1216189 S NA 0ZW0D Cluster_85116 V1216190 ASPC map00250,map00290,map01100,map01110,map01210,map01230 E Aminotransferase COG0436 Cluster_288677 V1216191 NFRA map00051,map00190,map00363,map00591,map00625,map00633,map00650,map01100,map01120 C nitroreductase COG0778 Cluster_306552 V1216192 K transcriptional regulator 0YJ72 Cluster_492111 V1216194 S Phage virion morphogenesis family 1281C Cluster_20845 V1216195 S Protein of unknown function (DUF935) COG4383 Cluster_338111 V1216196 S NA 0YDAR Cluster_234888 V1216197 L DNA primase 11GUV Cluster_62626 V1216199 PGN_0950 V ABC transporter, ATP-binding protein COG1132 Cluster_60140 V1216200 LMRA V ABC transporter, ATP-binding protein COG1132 Cluster_319895 V1216201 PYRP F permease COG2233 Cluster_273705 V1216202 LYC M glycoside hydrolase, family 25 11T0J Cluster_231258 V1216204 K transcriptional regulator, lysr family COG0583 Cluster_169456 V1216205 S domain protein 0YF83 Cluster_421509 V1216207 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_355389 V1216208 K Transcriptional regulator 1240D Cluster_89057 V1216209 S NA 101UU Cluster_408813 V1216211 V restriction enzyme 17CDW@proNOG Cluster_122150 V1216212 BL03512 M phage tail tape measure protein COG5283 Cluster_51323 V1216213 M Transferase COG1216 Cluster_164488 V1216214 S NA 0Y5S2 Cluster_181154 V1216215 GLFT1 M Glycosyl transferase, family 2 COG1216 Cluster_137470 V1216216 map00730,map04122 E Cysteine desulfurase COG0520 Cluster_227756 V1216217 QOR C Quinone oxidoreductase COG0604 Cluster_259038 V1216219 S NA 11X74 Cluster_6263 V1216220 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_219619 V1216221 YHBW C Luciferase family COG2141 Cluster_279055 V1216222 C l-carnitine dehydratase bile acid-inducible protein F COG1804 Cluster_245147 V1216223 TYRA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydrogenase COG0287 Cluster_428983 V1216224 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_11500 V1216225 MMPL2 S Membrane COG2409 Cluster_45360 V1216226 M Cell wall anchor domain protein 11Q8J Cluster_6597 V1216228 S NA 11QZ9 Cluster_371945 V1216233 SLYD O peptidylprolyl cis-trans isomerase COG1047 Cluster_25209 V1216234 S NA 0YRUB Cluster_107048 V1216235 HOM map00260,map00270,map00300,map01100,map01110,map01120,map01230 E homoserine dehydrogenase COG0460 Cluster_200883 V1216236 THRB map00260,map01100,map01120,map01230 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) COG0083 Cluster_702260 V1216238 S kila-n, DNA-binding domain 0XPNQ Cluster_785205 V1216239 S NA 1AQGC@spiNOG Cluster_347314 V1216240 S domain protein 0XNZW Cluster_348931 V1216242 CAS5D L CRISPR-associated protein 0XQ9Q Cluster_20079 V1216243 CAS3 L CRISPR-Associated Helicase Cas3 COG1203 Cluster_319896 V1216244 S NA 100T6 Cluster_277694 V1216245 O DnaJ domain protein COG0484 Cluster_300821 V1216246 OPPF map02010 E (ABC) transporter COG4608 Cluster_370328 V1216248 S Tetratricopeptide repeat protein 0XZXZ Cluster_248 V1216250 FAS map00061,map01100 I fatty acid synthase COG4982 Cluster_21405 V1216251 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_230085 V1216252 YQJG O Glutathione S-transferase COG0435 Cluster_196957 V1216253 MSRA O reductase COG0229 Cluster_430956 V1216254 K HTH_XRE 0XUC3 Cluster_124091 V1216255 MGTE P magnesium transporter COG2239 Cluster_348932 V1216256 S Structural protein 11PKS Cluster_392953 V1216262 S structural protein 11RQ6 Cluster_2243 V1216265 S NA COG5412 Cluster_175329 V1216266 S NA 0YZKI Cluster_69935 V1216267 S NA 0YENI Cluster_310717 V1216272 S twiN-arginine translocation pathway 0XZIK Cluster_262960 V1216276 SSEA map00270,map01100,map04122 P sulfurtransferase COG2897 Cluster_226624 V1216277 S NA 0XSAP Cluster_440941 V1216278 S Phage-associated protein 11FS5 Cluster_174516 V1216279 S phage protein 0XQDU Cluster_329082 V1216280 S NA 11VCX Cluster_51920 V1216282 S Endonuclease 0XNXZ Cluster_231259 V1216283 S NgoFVII restriction endonuclease 127ZV Cluster_196958 V1216284 map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_52825 V1216287 S NA 128RV Cluster_178621 V1216289 L Type I restriction modification DNA specificity domain COG0732 Cluster_28668 V1216290 M Minor structural protein 0XPF3 Cluster_6362 V1216292 S Phage tail tape measure protein, TP901 family COG5283 Cluster_589241 V1216294 S Phage protein 12BKU Cluster_428984 V1216295 S Phage major tail protein 2 0XU4M Cluster_640919 V1216297 S Phage protein, HK97 gp10 family 0Y04J Cluster_261666 V1216300 S NA 11V19 Cluster_403559 V1216301 S NA 127XX Cluster_259039 V1216302 S NA 0YVYG Cluster_118397 V1216304 T phage Mu protein F like protein COG5585 Cluster_113500 V1216305 BL00983 S Phage Portal Protein 11QNG Cluster_137471 V1216306 BL00759 L Phage terminase, large subunit COG1783 Cluster_504696 V1216307 PS333 L terminase (Small subunit) COG3728 Cluster_560736 V1216309 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_582750 V1216318 CKL_1885 S Protein of unknown function (DUF1064) 1251H Cluster_480346 V1216320 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_15102 V1216322 XYLS map00052,map00500,map01100 G hydrolase, family 31 COG1501 Cluster_674 V1216323 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_123459 V1216324 TGT J Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COG0343 Cluster_144964 V1216325 MVK map00900,map01100,map01110,map04146 I mevalonate kinase COG1577 Cluster_693 V1216327 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_116285 V1216328 RV3630 S Membrane 11JY2 Cluster_217327 V1216329 SCLAV_3115 O DSBA oxidoreductase COG1651 Cluster_214995 V1216330 GALE map00052,map00520,map00521,map00523,map01055,map01100,map01110 M Polysaccharide biosynthesis protein COG0451 Cluster_119119 V1216331 G transporter 0XP7I Cluster_161203 V1216332 ACX map00071,map00592,map01040,map01100,map03320,map04146 I acyl-CoA oxidase COG1960 Cluster_227757 V1216333 S integral membrane protein 11J5I Cluster_114875 V1216334 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0470 Cluster_137472 V1216335 S Membrane COG2311 Cluster_75163 V1216336 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG1754 Cluster_152875 V1216338 L Site-specific recombinase, phage integrase family 11F8N Cluster_135062 V1216339 S Conserved Protein COG4804 Cluster_62082 V1216340 S Protein of unknown function (DUF1524) COG1479 Cluster_373562 V1216341 S NA 0Y3II Cluster_246474 V1216342 S Relaxase mobilization nuclease 11PW0 Cluster_212688 V1216343 S NA 0ZC4R Cluster_113501 V1216344 S NA 1211J Cluster_322947 V1216349 D Chromosome Partitioning Protein COG1192 Cluster_300823 V1216355 THYA map00240,map00670,map01100 F Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) COG0207 Cluster_199878 V1216360 MT0027 M NLP P60 family protein COG0791 Cluster_339547 V1216367 S SNARE associated Golgi protein 0YNB0 Cluster_191662 V1216371 ECORIM L Modification methylase EcoRI 0XPU0 Cluster_99482 V1216374 PBPA map00550 M penicillin-binding protein COG0768 Cluster_38990 V1216375 PKNB T Serine Threonine protein kinase COG2815 Cluster_366998 V1216376 TRPG map00230,map00400,map00790,map00983,map01100,map01110,map01230 E anthranilate synthase COG0512 Cluster_640920 V1216377 S Transmembrane domain of unknown function (DUF3566) 11X32 Cluster_45361 V1216380 PLCN map00562,map00564,map00565,map01100 M phospholipase C COG3511 Cluster_266981 V1216381 S Alpha Beta Hydrolase COG4757 Cluster_144213 V1216382 NLPD M peptidase M23 COG0739 Cluster_361984 V1216383 map00630,map01100,map01110 S had-superfamily hydrolase, subfamily ia, variant COG0546 Cluster_428985 V1216384 BIOY map02010 S bioY protein COG1268 Cluster_277695 V1216385 K Transcriptional regulator 11GAC Cluster_36868 V1216386 S Secreted protein 0XRGW Cluster_237287 V1216387 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_636886 V1216388 S toxin-antitoxin system, antitoxin component, ribbon-helix-helix 11U5W Cluster_41040 V1216389 S Uncharacterized conserved protein (DUF2075) 0XPB6 Cluster_287324 V1216390 UDP map00230 S phosphorylase 11F11 Cluster_261667 V1216391 map02010 E, T ABC transporter substrate-binding protein COG0834 Cluster_14636 V1216392 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_75788 V1216393 GGT map00430,map00460,map00480,map00590,map01100 E gamma-glutamyltransferase COG0405 Cluster_338112 V1216394 THIE map00730,map01100 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) COG0352 Cluster_8114 V1216395 S NA 0YB9V Cluster_21625 V1216396 MPRF map05150 J Membrane COG2898 Cluster_6131 V1216397 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0047 Cluster_128180 V1216398 P Transporter COG0471 Cluster_194415 V1216400 S NA 0YZ0Q Cluster_216126 V1216412 RHUM S DNA-binding protein COG3943 Cluster_554750 V1216413 S Domain of unknown function (DUF955) 0Z637 Cluster_268384 V1216417 DMNB map03430 L D12 class N6 adenine-specific DNA methyltransferase COG0338 Cluster_171143 V1216419 L Integrase COG0582 Cluster_440942 V1216421 map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase family protein COG0406 Cluster_366999 V1216423 S NA 1224P Cluster_90910 V1216424 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_143463 V1216425 S UPF0597 protein COG3681 Cluster_166879 V1216429 K acetyltransferase COG0454 Cluster_245148 V1216431 S NA 11W41 Cluster_148820 V1216432 RV0433 S ATP-dependent carboxylate-amine ligase (By similarity) COG2170 Cluster_617861 V1216433 MRPG P monovalent cation proton antiporter, MnhG PhaG subunit 1224K Cluster_377046 V1216434 MRPE P monovalent cation H antiporter subunit E COG1863 Cluster_64840 V1216435 MRPD P Monovalent cation H antiporter subunit D COG0651 Cluster_12419 V1216436 MRPA map00190 P monovalent cation H antiporter subunit A COG2111 Cluster_296772 V1216437 MNTB map02010 P (ABC) transporter COG1121 Cluster_85117 V1216438 ERIC P Chloride channel COG0038 Cluster_115557 V1216439 V Mate efflux family protein COG0534 Cluster_211605 V1216440 GCVT map00260,map00670,map00910,map01100 E The glycine cleavage system catalyzes the degradation of glycine (By similarity) COG0404 Cluster_22099 V1216441 V Efflux ABC transporter, permease protein 0XPE8 Cluster_268385 V1216442 T Histidine kinase COG0642 Cluster_4816 V1216443 V abc transporter permease protein COG0577 Cluster_382314 V1216444 S Conjugative transposon protein TraI 0YE08 Cluster_232422 V1216445 TRAN S Conjugative transposon TraN protein 0XNQ2 Cluster_412489 V1216446 TRAO S conjugative transposon protein TraO 0YB3M Cluster_509868 V1216447 TRAQ2 S conjugative transposon protein TraQ 11SF8 Cluster_344111 V1216449 S UbiE COQ5 family 11KJ9 Cluster_380547 V1216450 S NA 0Z1FC Cluster_12076 V1216451 L N-6 DNA Methylase 0XTBT Cluster_731448 V1216453 S NA 0YWQY Cluster_135875 V1216454 S NA 0XNWW Cluster_198886 V1216455 S Oxidoreductase family, C-terminal alpha/beta domain COG0673 Cluster_327587 V1216464 S NA 11YW7 Cluster_284479 V1216467 LYTA M n-acetylmuramoyl-l-alanine amidase 123CS Cluster_582752 V1216468 S toxin secretion phage lysis holin 0XUV6 Cluster_179496 V1216476 METE map00270,map00450,map01100,map01110,map01230 E Methionine synthase COG0620 Cluster_10295 V1216477 S NA 0YB9V Cluster_6038 V1216478 V type I restriction-modification system COG0732 Cluster_138985 V1216480 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_378822 V1216481 RHTC E Lysine exporter protein (Lyse ygga) COG1280 Cluster_141260 V1216482 S Secreted protein 11J24 Cluster_241153 V1216483 PHEA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydratase COG0077 Cluster_108793 V1216484 AMIDASE map00330,map00360,map00380,map00627,map00643,map01120 J Amidase (EC 3.5.1.4) COG0154 Cluster_277696 V1216485 YNIA map00564,map01100 G Fructosamine kinase COG3001 Cluster_253995 V1216486 LYTR2 K TRANSCRIPTIONal COG1316 Cluster_249042 V1216487 SCLAV_2829 S Sec-C motif domain protein 100MK Cluster_44834 V1216489 PYKF4 map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG0469 Cluster_62370 V1216490 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_95700 V1216492 S Calcineurin-like phosphoesterase 0YC4X Cluster_152043 V1216493 FADE23 map00071,map00280,map00410,map00640,map01100,map01110,map03320 I acyl-Coa dehydrogenase 0XP8P Cluster_105186 V1216494 FADE24 map00281,map01110 I acyl-Coa dehydrogenase 0XT9E Cluster_80160 V1216495 SPEE map00270,map00330,map00410,map00480,map01100 E Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) COG4262 Cluster_471478 V1216496 RV2600 S Membrane 11XBK Cluster_463024 V1216499 GLGB map00500,map01100,map01110 G pullulanase, type i COG1523 Cluster_210468 V1216500 S NA 125P7 Cluster_233690 V1216502 S NurA domain protein 11IQE Cluster_54532 V1216503 S Domain of unknown function DUF87 COG0433 Cluster_6955 V1216504 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_6318 V1216505 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_285917 V1216506 ECFA1 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_273706 V1216507 ECFA2 map02010 P Abc transporter COG1122 Cluster_302216 V1216508 ECFT map02010 P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) COG0619 Cluster_333533 V1216509 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_380548 V1216510 RPLD map03010 J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) COG0088 Cluster_157812 V1216511 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_35428 V1216512 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_592607 V1216513 RPSL map03010 J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) COG0048 Cluster_380549 V1216514 map00240,map00330,map01100 G, M epimerase dehydratase COG0702 Cluster_9092 V1216515 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_266982 V1216516 L Recombinase COG1961 Cluster_281701 V1216519 M N-Acetylmuramoyl-L-alanine amidase COG3023 Cluster_497102 V1216520 S toxin secretion phage lysis holin COG4824 Cluster_13041 V1216522 M Phage minor structural protein COG4926 Cluster_465108 V1216523 S tail component COG4722 Cluster_16937 V1216524 CRES_0873 S Tape measure protein 0YD0X Cluster_551889 V1216526 CRES_0875 S NA 11SKH Cluster_482656 V1216528 YTSP T gaf domain protein COG1956 Cluster_184675 V1216529 S NA 0YXMU Cluster_23491 V1216530 M Ser Thr phosphatase family protein COG2247 Cluster_147280 V1216531 L site-specific recombinase, phage integrase family 0ZF8H Cluster_172873 V1216532 S NA 17MYW@proNOG Cluster_200884 V1216533 S NA 0XT2A Cluster_335035 V1216534 S NA 11MJM Cluster_225501 V1216535 S Nucleotidyl transferase of unknown function (DUF1814) 0XP6B Cluster_363553 V1216536 C PBS lyase HEAT domain protein repeat-containing protein COG1413 Cluster_789205 V1216537 S NA 11QA3 Cluster_621528 V1216538 S protein, conserved in bacteria COG1937 Cluster_31967 V1216539 ACTP P p-type atpase COG2217 Cluster_832234 V1216540 COPZ map04978 P heavy metal transport detoxification protein 0XUQ1 Cluster_161204 V1216541 V HNHc 125G9 Cluster_85911 V1216542 AMN map00230 F Amp nucleosidase COG0775 Cluster_137473 V1216543 MNTH P H( )-stimulated, divalent metal cation uptake system (By similarity) COG1914 Cluster_512447 V1216544 S multimeric flavodoxin wrba COG0655 Cluster_223150 V1216545 GLUQ map00860,map00970,map01100,map01110 J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) COG0008 Cluster_230086 V1216546 map02010 P ABC transporter COG1131 Cluster_196959 V1216548 UBIA H Prenyltransferase COG0382 Cluster_414354 V1216549 I Membrane-associated phospholipid phosphatase COG0671 Cluster_39147 V1216550 GLFT M Transferase COG1216 Cluster_245149 V1216551 CMTB S esterase COG0627 Cluster_243876 V1216552 S EamA-like transporter family 129W1 Cluster_93293 V1216553 CSP M n-acetylmuramoyl-l-alanine amidase COG5479 Cluster_25210 V1216554 CSP M n-acetylmuramoyl-l-alanine amidase COG5479 Cluster_336568 V1216555 MT3922 S hydrolase COG0561 Cluster_93294 V1216556 PLSC map00561,map00564,map01100 I Acyl-transferase 0Z3QU Cluster_14637 V1216557 HSDR V Type I Restriction COG0610 Cluster_31739 V1216558 FADB map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00640,map00650,map00720,map00903,map00930,map01040,map01100,map01110,map01120 I 3-hydroxyacyl-CoA dehydrogenase COG1250 Cluster_74182 V1216559 YDIU S UPF0061 protein COG0397 Cluster_60959 V1216560 DPPA map02010 E ABC transporter substrate-binding protein COG4166 Cluster_245150 V1216561 DPPB map02010 P ABC transporter (Permease) COG0601 Cluster_211606 V1216562 DPPC map02010 P ABC transporter (Permease) COG1173 Cluster_281702 V1216563 CITE map00020,map01110,map02020 G Citrate lyase COG2301 Cluster_37324 V1216564 map00061,map00280,map00630,map00640,map00720,map01100,map01120 I carbamoyL-phosphate synthase l chain ATP-binding COG4770 Cluster_78111 V1216565 MCCB map00280,map00720,map01100,map01120 I carboxylase COG4799 Cluster_53273 V1216566 S Membrane 11NP1 Cluster_480347 V1216567 S Thioesterase 11UBJ Cluster_338113 V1216568 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_110739 V1216569 MNME S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 Cluster_184676 V1216570 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_126797 V1216573 S NA 0XPEA Cluster_128181 V1216574 GSHA map00480,map01100 H glutamate--cysteine ligase COG3572 Cluster_306553 V1216575 S Metal dependent hydrolase COG2220 Cluster_17142 V1216576 ATP2C1 P p-type ATPase COG0474 Cluster_19204 V1216577 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_499766 V1216580 OGT L Methyltransferase COG0350 Cluster_59586 V1216581 S Membrane 0ZI5H Cluster_209396 V1216582 LTAE map00260,map01100,map01110,map01120,map01230 E Aldolase COG2008 Cluster_69936 V1216583 map02010 E ABC, transporter COG4166 Cluster_249043 V1216584 OPPC map02010 P abc transporter, permease COG1173 Cluster_382315 V1216585 NT5E map00230,map00240,map00630,map00760,map01100,map01110 S Hydrolase COG0546 Cluster_279056 V1216586 AADK S Aminoglycoside 6-adenylyltransferase 0YSKJ Cluster_781083 V1216587 ENTF map00250,map01053,map01054 Q non-ribosomal peptide synthetase COG1020 Cluster_392954 V1216588 S integral membrane protein 11P1U Cluster_327588 V1216589 map02010 P Cobalt transport protein COG0619 Cluster_92359 V1216590 SLGD_00064 map02010 P ABC transporter COG1122 Cluster_62900 V1216591 map02010 V ABC transporter COG1132 Cluster_59072 V1216592 V abc transporter COG1132 Cluster_307861 V1216593 IRP4 Q Thioesterase COG3208 Cluster_161205 V1216594 M glycosyl transferase family COG1819 Cluster_391139 V1216595 MAA map00350,map00362,map00627,map00642,map00903,map01120 E O-Acetyltransferase COG0110 Cluster_193478 V1216596 map02010 P ABC transporter 0XXUP Cluster_319897 V1216597 DRRB map02010 V ABC, transporter COG0842 Cluster_434885 V1216599 TPAU_0274 L transposase COG3547 Cluster_104592 V1216601 S NA 0Z34Z Cluster_37800 V1216602 L Dna topoisomerase COG0550 Cluster_119889 V1216603 NNRD G Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) COG0063 Cluster_108180 V1216604 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_113503 V1216605 TRKA P potassium transporter peripheral membrane COG0569 Cluster_96287 V1216606 TRKH P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) COG0168 Cluster_106412 V1216607 TRKA P potassium transporter peripheral membrane COG0569 Cluster_336569 V1216608 SUPH S Hydrolase COG0561 Cluster_423367 V1216609 AARI_34720 L Transposase COG3547 Cluster_469332 V1216610 AARI_34720 L Transposase COG3547 Cluster_471479 V1216612 S Transporter Permease Protein 0Z4FB Cluster_30581 V1216613 YKOD map02010 P ABC transporter COG1122 Cluster_330482 V1216614 FADD32 I, Q amp-dependent synthetase and ligase COG1020 Cluster_324523 V1216616 DRRB map02010 V ABC, transporter COG0842 Cluster_63460 V1216618 IRTA map02010 V abc transporter COG1132 Cluster_401781 V1216619 CHER Q Methyltransferase COG0500 Cluster_257714 V1216620 map00051,map00500,map00520,map01100 G pfkb domain protein COG0524 Cluster_465109 V1216621 SCRA map00500,map02060 G PTS system COG2190 Cluster_288679 V1216622 FNT P nitrite transporter COG2116 Cluster_163680 V1216623 P drug resistance transporter, Bcr CflA 0XNNX Cluster_51524 V1216625 BIOF map00260,map00780,map01100 H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) COG1424 Cluster_442956 V1216626 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_55243 V1216627 MT1099 S Membrane COG4425 Cluster_410672 V1216628 SODA map04146,map05016 P Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) COG0605 Cluster_54533 V1216629 S recb family COG2251 Cluster_59882 V1216630 PHOD map00627,map00790,map01100,map01120,map02020 P Alkaline phosphatase COG3540 Cluster_115558 V1216631 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins COG0706 Cluster_396547 V1216632 MCBR K Transcriptional regulator 11WG2 Cluster_695900 V1216633 S Transglycosylase associated protein 0Z2KY Cluster_6242 V1216634 YLBB V abc transporter permease protein COG0577 Cluster_367000 V1216635 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_59346 V1216636 PGM map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_378823 V1216637 DEOC map00030 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) COG0274 Cluster_132637 V1216638 DEOA map00240,map00983,map01100,map05219 F The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) COG0213 Cluster_542984 V1216639 CDD map00240,map00983,map01100,map05219 F cytidine deaminase COG0295 Cluster_209397 V1216640 YJHU map00561,map00680,map01100,map01120,map04622 K Transcriptional regulator COG2390 Cluster_45362 V1216641 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_234890 V1216642 M lysozyme COG3757 Cluster_243877 V1216643 L decarboxylase COG1611 Cluster_423368 V1216644 MAF D MAF-like protein COG0424 Cluster_72157 V1216648 PPAC map00190 C Manganese-dependent inorganic pyrophosphatase COG1227 Cluster_741425 V1216649 RPSR map03010 J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) COG0238 Cluster_74812 V1216650 GLT map00630,map00910 E Glutamate synthase COG0069 Cluster_442957 V1216651 PURE map00230,map01100,map01110 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) COG0041 Cluster_71513 V1216652 PCCB map00280,map00630,map00640,map00720,map01100,map01120 I carboxyl transferase COG4799 Cluster_72819 V1216653 PCCB map00280,map00630,map00640,map00720,map01100,map01120 I propionyl-CoA carboxylase COG4799 Cluster_46524 V1216655 V restriction COG1401 Cluster_606778 V1216656 DIND S DNA-damage-inducible protein d 176AU@proNOG Cluster_350551 V1216657 RDGB map00230,map00240,map01100 F Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) COG0127 Cluster_271045 V1216658 MURI map00230,map00240,map00471,map01100 M Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) COG0796 Cluster_182080 V1216659 DMPA E, Q peptidase s58 dmpa COG3191 Cluster_438969 V1216660 S Domain of unknown function (DUF2017) 0XSEV Cluster_125406 V1216661 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_217328 V1216662 G Major Facilitator superfamily 0Z6XG Cluster_477933 V1216664 S NA 0YGJM Cluster_64018 V1216667 P sulfate transporter COG0659 Cluster_300824 V1216668 C Monooxygenase COG2141 Cluster_606779 V1216669 CMTR K arsR family transcriptional regulator COG0640 Cluster_49368 V1216670 CADA P heavy metal translocating p-type ATPase COG2217 Cluster_851745 V1216671 S NA 0Z8JS Cluster_335036 V1216672 S Pfam:DUF1089 12580 Cluster_520366 V1216673 YAEJ J class I peptide chain release factor COG1186 Cluster_731450 V1216674 S plasmid maintenance system antidote protein, xre family COG3093 Cluster_708446 V1216675 S Plasmid maintenance system killer COG3549 Cluster_967 V1216676 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_276390 V1216677 MREC M Involved in formation and maintenance of cell shape (By similarity) COG1792 Cluster_367001 V1216678 RADC L DNA repair protein (RadC COG2003 Cluster_220805 V1216679 SP_0859 S Membrane COG3817 Cluster_365290 V1216680 ENC_10390 S Membrane COG3819 Cluster_425155 V1216681 RNFG C Electron transport complex, RnfABCDGE type, G subunit COG4659 Cluster_122827 V1216682 RNFC C Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) COG4656 Cluster_384098 V1216683 M lytic transglycosylase COG0741 Cluster_95701 V1216684 FADD4 map00071,map01100,map03320,map04146,map04920 Q Amp-dependent synthetase and ligase COG0318 Cluster_245151 V1216685 THRB map00260,map01100,map01120,map01230 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) COG0083 Cluster_121388 V1216686 HOM map00260,map00270,map00300,map01100,map01110,map01120,map01230 E homoserine dehydrogenase COG0460 Cluster_102795 V1216687 LYSA map00300,map01100,map01110,map01120,map01230 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) COG0019 Cluster_70234 V1216688 ARGS map00970 J arginyL-tRNA synthetase COG0018 Cluster_375278 V1216689 YVFV map00630,map01100,map01110,map01120 C glycolate oxidase (iron-sulfur subunit) COG0247 Cluster_82120 V1216690 BMUL_5818 C Iron-sulfur cluster binding protein COG1139 Cluster_342521 V1216691 S Conserved Protein COG1556 Cluster_207229 V1216692 O pirin domain protein COG1741 Cluster_665443 V1216693 FECE map02010 P ABC transporter, ATP-binding protein COG1120 Cluster_182081 V1216694 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_796948 V1216695 YAAA S s4 domain protein COG2501 Cluster_192592 V1216696 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_47695 V1216697 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_640923 V1216698 RSBV T stage II sporulation protein COG1366 Cluster_401782 V1216700 V ABC, transporter COG1136 Cluster_112763 V1216701 FUMC map00020,map00720,map01100,map01110,map01120,map05200,map05211 C fumarate hydratase class II COG0114 Cluster_134262 V1216703 map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) COG1156 Cluster_62627 V1216704 CYDD map02010 V ABC, transporter COG4988 Cluster_333534 V1216705 YAAA L UPF0246 protein COG3022 Cluster_280360 V1216706 map02020 K Transcriptional regulator, ARAC family 11AZ4 Cluster_140507 V1216707 PYRP F permease COG2233 Cluster_554751 V1216708 map02020 V ABC transporter, permease COG0577 Cluster_38313 V1216709 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_416138 V1216710 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_145712 V1216711 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_27581 V1216712 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_438970 V1216713 YFCE S Phosphodiesterase COG0622 Cluster_47867 V1216714 UUP S Abc transporter COG0488 Cluster_285918 V1216715 VICX map03013 S domain protein COG1235 Cluster_288680 V1216716 TTCA D Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) COG0037 Cluster_156947 V1216717 FPRA C domain protein COG0426 Cluster_69605 V1216718 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_118398 V1216719 GCVPA map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG0403 Cluster_96288 V1216720 GCVPB map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG1003 Cluster_104593 V1216721 LPDA map00010,map00020,map00260,map00280,map00620,map01100,map01110,map01120 C dihydrolipoyl dehydrogenase COG1249 Cluster_154450 V1216722 HTRA map03010 M peptidase S1 and S6, chymotrypsin Hap COG0265 Cluster_117711 V1216723 YJIN S Membrane COG2733 Cluster_138986 V1216724 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_53274 V1216725 FADD map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG0318 Cluster_119120 V1216726 MSHA M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) COG0438 Cluster_8901 V1216727 FADF C Fe-S oxidoreductase COG0247 Cluster_368613 V1216728 T response regulator COG2197 Cluster_365291 V1216729 S NA 0YBW6 Cluster_412490 V1216730 S NA 0YHQV Cluster_176125 V1216731 C Luciferase-like COG2141 Cluster_417938 V1216732 ASPC map00250,map00290,map01100,map01110,map01210,map01230 E Aminotransferase COG0436 Cluster_212689 V1216733 S oxidoreductase 11GP7 Cluster_473593 V1216734 S Protein of unknown function (DUF1469) 102XY Cluster_224322 V1216735 EPHE S Alpha Beta Hydrolase Fold protein 0XRPK Cluster_275057 V1216736 SCLAV_2562 L nudix hydrolase COG0494 Cluster_319898 V1216737 MT3774 O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG0526 Cluster_309279 V1216738 NTH map03410 L endonuclease III COG0177 Cluster_492112 V1216740 SCLAV_2568 J endoribonuclease L-psp COG0251 Cluster_217329 V1216742 SCLAV_5135 S NA 0YWD2 Cluster_777343 V1216744 S NA 0YXSW Cluster_247736 V1216745 S NA 0YS7C Cluster_617862 V1216746 E Branched-chain amino acid 12BFW Cluster_275058 V1216747 CG3417 L nudix hydrolase COG0494 Cluster_27180 V1216748 MT4028 S NA 0XRB8 Cluster_281703 V1216749 CMTB S esterase COG0627 Cluster_42774 V1216750 CMTC M Trehalose corynomycolyl transferase COG5479 Cluster_246475 V1216752 ELRF S cutinase 11FQ6 Cluster_507281 V1216753 S TM2 domain COG2314 Cluster_85118 V1216754 DTPT E Transporter COG3104 Cluster_625312 V1216755 TRMB C Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_79788 V1216756 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_22700 V1216758 V FtsX-like permease family 0ZW5X Cluster_361985 V1216759 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_380550 V1216760 T response regulator COG0745 Cluster_88568 V1216761 GPMI map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0696 Cluster_189015 V1216762 COBD map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01230 E decarboxylase COG0079 Cluster_183799 V1216763 LTAE map00260,map01100,map01110,map01120,map01230 E Aldolase COG2008 Cluster_199879 V1216764 S filamentation induced by cAMP protein Fic COG3177 Cluster_15570 V1216765 ACTP P Copper-exporting ATPase COG2217 Cluster_438971 V1216766 CYSE map00270,map00920,map01100,map01120,map01230 E serine acetyltransferase COG1045 Cluster_287325 V1216767 NFO map03410 L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) COG0648 Cluster_276391 V1216768 NADE map00760,map01100 H nh(3)-dependent nad( ) synthetase COG0171 Cluster_454950 V1216769 K Tetr family transcriptional regulator COG1309 Cluster_335037 V1216770 O Secreted protein COG1651 Cluster_523145 V1216771 S doxx family 11VM9 Cluster_188173 V1216772 YLBL T Secreted protein COG3480 Cluster_92360 V1216773 SCLAV_4061 S Uncharacterised conserved protein (DUF2342) COG5282 Cluster_534403 V1216774 S metal-dependent hydrolase COG1451 Cluster_5453 V1216775 M NA 0ZP9N Cluster_1366 V1216776 APRE O Peptidase S8 and S53 subtilisin kexin sedolisin COG4412 Cluster_291288 V1216777 ESSC D ftsk spoIIIe COG1674 Cluster_88569 V1216778 S Protein of unknown function (DUF690) 11F8D Cluster_751504 V1216782 NRDH O (Glutaredoxin-like protein) NrdH COG0695 Cluster_120618 V1216787 NOX map00190 P pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_45363 V1216788 FBP map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120 G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 COG3855 Cluster_454951 V1216789 LEPB map03060 U Signal peptidase i COG0681 Cluster_132638 V1216790 S -dicarboxylate symporter COG1823 Cluster_504698 V1216791 map00633,map00680,map00720,map01120 C domain protein COG2080 Cluster_313738 V1216792 YGFM map00450 C FAD binding domain in molybdopterin dehydrogenase 0YU1D Cluster_149586 V1216793 M glycosyl transferase group 1 0ZWDI Cluster_143464 V1216794 ALBF P drug resistance transporter, EmrB QacA subfamily 0XNN3 Cluster_355390 V1216795 S aaa ATPase COG3910 Cluster_648831 V1216796 S Resuscitation-promoting factor 11WB2 Cluster_249044 V1216798 map00680,map00982,map01120 P oxidoreductase COG2072 Cluster_201878 V1216799 YGHZ map00051,map00363,map00591,map00625,map00650,map01100,map01120 C Aldo keto reductase COG0667 Cluster_275059 V1216800 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_44659 V1216801 E peptidase s9, prolyl oligopeptidase COG1506 Cluster_9155 V1216802 DNAE2 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase (By similarity) COG0587 Cluster_350552 V1216803 METI map02010 P ABC transporter, permease COG2011 Cluster_152876 V1216806 ILVA map00260,map00290,map01100,map01110,map01230 E threonine COG1171 Cluster_252737 V1216807 CITG map02020 H triphosphoribosyl-dephospho-CoA synthase COG1767 Cluster_4665 V1216808 O cysteine protease COG4870 Cluster_333535 V1216809 map00680 C Na H antiporter COG1757 Cluster_35994 V1216811 M efflux transporter, rnd family, mfp subunit COG0845 Cluster_141261 V1216812 V ABC transporter, permease COG0577 Cluster_209398 V1216813 MENC map00130,map01100,map01110 H O-succinylbenzoate synthase COG4948 Cluster_469333 V1216814 FECE map02010 P ABC transporter COG1120 Cluster_170319 V1216815 map02010 P ABC transporter permease COG0609 Cluster_176949 V1216816 YIUA map02010 P Periplasmic binding protein COG0614 Cluster_106413 V1216817 NORM V Mate efflux family protein COG0534 Cluster_252738 V1216818 TSB map00260,map00270,map01100,map01230 E Cysteine synthase COG0031 Cluster_89971 V1216819 SSCG_02586 map00300,map01100,map01110,map01120,map01230 E decarboxylase COG0019 Cluster_197891 V1216820 map00330,map01110,map01230 E Ornithine cyclodeaminase 10EHU Cluster_242525 V1216821 YDED E, G Membrane COG0697 Cluster_407058 V1216822 S CAAX amino terminal protease family 11SPS Cluster_125407 V1216823 YIEG S Xanthine uracil vitamin C permease COG2252 Cluster_5127 V1216824 S Inherit from NOG: LPXTG-motif cell wall anchor domain protein 0YEBJ Cluster_758483 V1216825 S sigma-70, region 4 11JJM Cluster_116994 V1216826 V MatE COG0534 Cluster_231260 V1216827 S NA 121AE Cluster_499767 V1216829 TRML map04122 J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) COG0219 Cluster_76095 V1216830 P Na Pi-cotransporter COG1283 Cluster_214996 V1216831 GAP map00010,map01100,map01110,map01120,map01230,map04066,map05010 G glyceraldehyde-3-phosphate dehydrogenase COG0057 Cluster_158689 V1216832 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_315325 V1216833 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_81749 V1216834 GPMI map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0696 Cluster_132639 V1216835 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_105804 V1216837 S Membrane COG4129 Cluster_355391 V1216838 SCLAV_3949 S Domain of unknown function (DUF1707) 11SS5 Cluster_300825 V1216839 S NA 11R2V Cluster_131891 V1216840 PURA map00230,map00250,map01100 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis COG0104 Cluster_147282 V1216842 GLPQ map00564 C glycerophosphoryl diester phosphodiesterase COG0584 Cluster_203967 V1216843 IUNH map00230,map00240,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_482658 V1216844 L NUDIX hydrolase COG0494 Cluster_220806 V1216845 NUSA K Transcription elongation factor NusA COG0195 Cluster_194416 V1216847 NRNA J phosphoesterase RecJ domain protein COG0618 Cluster_141262 V1216848 DINF V Mate efflux family protein COG0534 Cluster_231261 V1216849 LYTR K TRANSCRIPTIONal COG1316 Cluster_211607 V1216850 FNI map00900,map01100,map01110 C Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) COG1304 Cluster_450976 V1216851 BIOY map02010 S bioY protein COG1268 Cluster_357079 V1216852 S TIM-barrel fold 11FGY Cluster_194417 V1216853 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E amino acid aminotransferase COG0115 Cluster_53275 V1216854 CAPD map00051,map00362,map00363,map00521,map00523,map00591,map00625,map00626,map00650,map00903,map01055,map01100,map01110,map01120 M Polysaccharide biosynthesis protein COG1086 Cluster_226625 V1216855 map00260,map00680,map01100,map01120,map01230 E, H D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain COG0111 Cluster_361986 V1216856 K Transcriptional regulator, GntR family COG1802 Cluster_64019 V1216857 LMRA map02010 V abc transporter COG1132 Cluster_60960 V1216858 YFIC map02010 V ABC transporter COG1132 Cluster_162882 V1216859 BDHA map00051,map00363,map00591,map00625,map00650,map01100,map01120 C alcohol dehydrogenase COG1979 Cluster_318419 V1216860 SSUC map02010 P Binding-protein-dependent transport systems, inner membrane component COG0600 Cluster_345740 V1216861 S NA 0ZMT1 Cluster_162035 V1216865 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_332046 V1216867 SCLAV_0494 S integral membrane protein 11SWN Cluster_45568 V1216869 L Domain protein COG0507 Cluster_100557 V1216870 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0847 Cluster_711573 V1216873 O ADP-ribosylglycohydrolase COG1397 Cluster_875903 V1216874 O ADP-ribosylglycohydrolase COG1397 Cluster_161206 V1216875 NATB C, P ABC transporter, permease COG1668 Cluster_188174 V1216876 S Membrane COG4194 Cluster_585936 V1216877 K Transcriptional regulator, GntR family COG1725 Cluster_116286 V1216878 map00190,map00680,map01100 C ATP synthase alpha/beta chain, C terminal domain COG1155 Cluster_269733 V1216879 SCLAV_2396 H NADP oxidoreductase, coenzyme f420-dependent COG5495 Cluster_136683 V1216880 S NA 11QQB Cluster_212690 V1216881 FOLP map00790,map01100 H dihydropteroate synthase COG0294 Cluster_423369 V1216882 FOLE map00790,map01100 H GTP cyclohydrolase i COG0302 Cluster_17370 V1216883 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_758484 V1216884 S Inherit from COG: Alpha beta hydrolase COG0596 Cluster_828515 V1216885 S reductase COG1028 Cluster_152877 V1216886 S copper amine 121X1 Cluster_265672 V1216887 S NA 0YIZN Cluster_542985 V1216888 S NA 0YRPX Cluster_247737 V1216891 PYRB map00240,map00250,map01100 F aspartate transcarbamylase COG0540 Cluster_534404 V1216892 PYRI map00240,map00250,map01100 F Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) COG1781 Cluster_156100 V1216893 PYRC map00230,map00240,map00410,map00770,map00983,map01100,map01120 F dihydroorotase COG0044 Cluster_277697 V1216894 PYRF map00240,map00983,map01100 F orotidine 5''-phosphate decarboxylase COG0284 Cluster_342522 V1216895 PYRK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) COG0543 Cluster_257715 V1216896 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate (By similarity) COG0167 Cluster_425156 V1216897 PYRE map00240,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_348933 V1216898 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_310718 V1216899 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_193479 V1216900 ISPG map00900,map01100,map01110 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) COG0821 Cluster_216127 V1216901 NTPC map00190,map00680,map01100 C ATP synthase subunit C COG1527 Cluster_436934 V1216902 ATPE map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG1390 Cluster_46141 V1216903 NTPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_365292 V1216904 UPP map00240,map01100 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) COG0035 Cluster_205042 V1216905 SUA J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0009 Cluster_214997 V1216906 YBHK S UPF0052 protein COG0391 Cluster_275060 V1216907 YHBJ S Displays ATPase and GTPase activities (By similarity) COG1660 Cluster_326022 V1216908 HIS2 L PHP domain protein COG1387 Cluster_442958 V1216909 RPLE map03010 J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COG0094 Cluster_440943 V1216910 OGT L Methyltransferase COG0350 Cluster_198887 V1216912 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_256432 V1216913 I May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) COG1597 Cluster_142766 V1216914 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_403561 V1216915 UDK map00240,map00710,map00983,map01100,map01120 F uridine monophosphokinase COG0572 Cluster_37325 V1216916 TEX K domain protein COG2183 Cluster_62628 V1216917 PEPTIDASE E prolyl oligopeptidase COG1505 Cluster_99483 V1216918 RAMB K transcriptional regulator COG3800 Cluster_292647 V1216919 S abc transporter atp-binding protein 0XQ1Z Cluster_132640 V1216920 MLEP map02020 C citrate carrier protein COG3493 Cluster_162883 V1216921 MDH map00620,map00710,map01100,map01120,map02020 C malate dehydrogenase (Oxaloacetate-decarboxylating) COG0281 Cluster_152044 V1216922 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_95203 V1216923 YCAM E amino acid COG0531 Cluster_94686 V1216924 NRDF map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_212691 V1216925 BIOB map00780,map01100 H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) COG0502 Cluster_189880 V1216926 NADA map00760,map01100 H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) COG0379 Cluster_96807 V1216927 NADB map00250,map00760,map01100 H L-aspartate oxidase COG0029 Cluster_277698 V1216931 VDLC S short-chain dehydrogenase reductase COG1028 Cluster_150445 V1216932 SCLAV_5207 map00300,map00310,map01100,map01110,map01230 S Saccharopine dehydrogenase COG3268 Cluster_152878 V1216933 YNFM G Major Facilitator Superfamily 0XP8J Cluster_151214 V1216934 S Filamentation induced by cAMP protein fic COG3177 Cluster_335038 V1216935 YLME F alanine racemase domain protein COG0325 Cluster_557674 V1216936 GUAB3 map00230,map00983,map01100,map01110 F Dehydrogenase COG0516 Cluster_60649 V1216937 CHOD map00984 E Cholesterol oxidase COG2303 Cluster_78785 V1216938 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_669752 V1216940 S Antibiotic biosynthesis monooxygenase COG2329 Cluster_347316 V1216941 RV3395C S DNA repair 129Q4 Cluster_68894 V1216942 MT3501 L polymerase involved in DNA repair COG0389 Cluster_502298 V1216943 S Secreted protein 11Z2N Cluster_333536 V1216944 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_398273 V1216945 MAG map03410 L 3-methyladenine DNA glycosylase COG2094 Cluster_389406 V1216946 PYRE map00240,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_21766 V1216947 SURB S G5 domain protein 0ZVV3 Cluster_175330 V1216948 APBE H ApbE family COG1477 Cluster_291289 V1216949 PS305 S Protein of unknown function (Hypoth_ymh) 10DNB Cluster_44835 V1216950 POLA_2 L DNA polymerase 0XRUF Cluster_436935 V1216952 S Phage-associated protein 11FS5 Cluster_173709 V1216953 S phage protein 0XQDU Cluster_540108 V1216954 S rRNA biogenesis protein Rrp5 0XUK3 Cluster_417939 V1216956 S NA 0Z4HT Cluster_144965 V1216957 S NA 11HCX Cluster_762245 V1216958 S NA 0XZ2W Cluster_52591 V1216959 ASNB map00250,map00910,map01100,map01110,map01120 E asparagine synthetase COG0367 Cluster_162036 V1216960 COXB map00190,map00910,map01100 C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) COG1622 Cluster_62629 V1216961 EXPZ S ABC transporter COG0488 Cluster_72820 V1216962 C Inherit from COG: Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) COG1290 Cluster_224323 V1216963 QCRA map00190,map00910,map01100,map02020,map04260,map05010,map05012,map05016 C c reductase, iron-sulfur COG0723 Cluster_124092 V1216964 HOXA map02020 T Sigma-54 interaction domain protein COG2204 Cluster_27967 V1216965 T ATPase histidine kinase DNA gyrase B HSP90 domain protein 0XNMH Cluster_484984 V1216968 S HD domain protein COG1418 Cluster_62083 V1216969 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG0469 Cluster_231262 V1216970 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G phosphohexokinase COG0205 Cluster_458857 V1216971 COAA map00770,map01100 H pantothenic acid kinase COG1072 Cluster_150446 V1216972 V Hnh endonuclease 11M4H Cluster_440944 V1216973 SAT2 map00350,map00362,map00627,map00642,map00903,map01120 K gCN5-related N-acetyltransferase COG0454 Cluster_321381 V1216974 PAAB map00360,map01120 Q Enoyl-CoA hydratase COG1024 Cluster_79478 V1216975 METP P -transporter COG0733 Cluster_119121 V1216976 S nucleoside recognition domain protein COG3314 Cluster_187315 V1216977 ARSB P arsenicaL-resistance protein COG0798 Cluster_208349 V1216978 S Copper amine oxidase N-terminal domain 0YD2Q Cluster_494597 V1216979 MGSA map00620 G methylglyoxal synthase COG1803 Cluster_155291 V1216980 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_154451 V1216981 FABG map00061,map00780,map01040,map01100 I reductase COG1028 Cluster_3267 V1216983 S Inherit from NOG: Mediates binding to human platelets, possibly through a receptor-ligand interaction. Probably associated with virulence in endovascular infection (By similarity) 12CMI Cluster_199880 V1216985 M NLP P60 protein COG0791 Cluster_144214 V1216986 S NA 0YHMP Cluster_196146 V1216987 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_384099 V1216988 S NA 11MYY Cluster_261669 V1216989 RECB L recb family COG2887 Cluster_126097 V1216990 DCUA map02020 O Anaerobic c4-dicarboxylate transporter COG2704 Cluster_97353 V1216991 ASPA map00250,map00910,map01100 E Aspartate ammonia-lyase COG1027 Cluster_176126 V1216992 SERB1 E HAD-superfamily subfamily IB hydrolase COG0560 Cluster_102251 V1216993 HEMA map00860,map01100,map01110 H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) COG0373 Cluster_68559 V1216994 HEMD map00860,map01100,map01110 H synthase COG1587 Cluster_287326 V1217003 NHAP P Na H antiporter COG0025 Cluster_10724 V1217004 S conserved repeat domain protein 0ZW39 Cluster_67520 V1217009 YJJK S ABC transporter, ATP-binding protein COG0488 Cluster_110740 V1217012 K Transcriptional regulator GntR family COG1167 Cluster_269734 V1217013 PDXS map00750 H Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) COG0214 Cluster_252739 V1217014 L Membrane COG4905 Cluster_166880 V1217015 NIFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_295432 V1217016 SOJ D Chromosome Partitioning Protein COG1192 Cluster_416139 V1217017 M cell wall-binding protein COG2247 Cluster_10769 V1217019 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_217330 V1217020 NQRB C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG1805 Cluster_405369 V1217021 RNFG S FMN-binding domain-containing protein 12937 Cluster_399995 V1217022 NQRD C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG1347 Cluster_417940 V1217023 NQRE C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG2209 Cluster_469334 V1217025 MENA map00130,map01100,map01110 H 1,4-dihydroxy-2-naphthoate octaprenyltransferase COG1575 Cluster_169458 V1217026 MENE map00130,map01100,map01110 H o-succinylbenzoic acid-CoA ligase COG0318 Cluster_375279 V1217027 MSRA O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) COG0225 Cluster_160373 V1217028 S Membrane COG3949 Cluster_329084 V1217030 STPC map02010 V ABC, transporter COG1131 Cluster_347318 V1217031 T Two component transcriptional regulator luxr family COG2197 Cluster_147283 V1217032 SCLAV_2731 T Histidine kinase 11T0E Cluster_405370 V1217033 ALKB L Alkylated DNA repair protein COG3145 Cluster_208350 V1217034 SELU S Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) COG2603 Cluster_53783 V1217035 M Sulfatase COG1368 Cluster_225502 V1217036 S NA 0ZSFH Cluster_162037 V1217037 U Pfam:GSPII_E COG4962 Cluster_385862 V1217038 MT3758 U Type ii secretion system COG4965 Cluster_377047 V1217039 U type ii secretion system 123KS Cluster_718196 V1217040 RV3656C S NA 12265 Cluster_27094 V1217042 MT3751 L Helicase COG1205 Cluster_276392 V1217043 K, T Phage shock protein A COG1842 Cluster_279057 V1217044 HPAF map00350,map01100,map01120 Q Fumarylacetoacetate hydrolase COG0179 Cluster_76766 V1217045 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_540109 V1217046 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_59587 V1217047 HSDM V type I restriction-modification system COG0286 Cluster_176127 V1217048 PUCG map00250,map00260,map00630,map00680,map01100,map01110,map01120,map04146 E Aminotransferase COG0075 Cluster_259040 V1217050 S copper amine 121X1 Cluster_419711 V1217051 O Tryp_SPc 0YAAN Cluster_120619 V1217052 GLTT E glutamate COG0786 Cluster_74813 V1217054 S Relaxase/Mobilisation nuclease domain 0YUGU Cluster_138235 V1217057 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_699174 V1217058 J CRS1 / YhbY (CRM) domain COG1534 Cluster_460904 V1217059 RSMI G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 Cluster_67521 V1217060 BETP P Transporter COG1292 Cluster_138236 V1217061 PABB map00400,map00790,map01100,map01110,map01230 E, H synthase component I COG0147 Cluster_289976 V1217062 TATD L Hydrolase, tatD family COG0084 Cluster_318420 V1217063 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_460905 V1217064 S Abortive infection protein AbiGII 0XQHH Cluster_487255 V1217066 FOLA map00670,map00790,map01100 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) COG0262 Cluster_284480 V1217067 THYA map00240,map00670,map01100 F Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) COG0207 Cluster_322948 V1217068 CYSQ map00920,map01100,map01120 P inositol mono-phosphatase COG1218 Cluster_199881 V1217069 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120 G phosphohexose isomerase COG0166 Cluster_91375 V1217070 YEEE O YeeE YedE family protein COG2391 Cluster_230087 V1217071 S NA 0YHWM Cluster_316851 V1217072 PCS map00564 I Phosphatidylcholine synthase COG1183 Cluster_82540 V1217073 GABD2 map00010,map00040,map00053,map00071,map00250,map00280,map00310,map00330,map00340,map00350,map00360,map00380,map00410,map00561,map00620,map00625,map00640,map00643,map00650,map00903,map01100,map01110,map01120 C Dehydrogenase COG1012 Cluster_465111 V1217074 GREA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) COG0782 Cluster_446979 V1217075 LEGAS_1040 L transposase COG2963 Cluster_816897 V1217076 S NA 0Z7SI Cluster_365293 V1217077 K Transcriptional regulator 123QU Cluster_306554 V1217078 UBIE map00340,map00350,map00624,map01120 Q methyltransferase COG0500 Cluster_520368 V1217079 LYTR1 K TRANSCRIPTIONal COG1316 Cluster_731451 V1217080 O hydrogenase 12C73 Cluster_116287 V1217081 HOXH map00680 C Nickel-dependent hydrogenase large subunit COG3259 Cluster_385863 V1217082 O maturation protease COG0680 Cluster_60650 V1217083 HYAB map00633,map01120 C Hydrogenase, large subunit COG0374 Cluster_171145 V1217084 HYAA map00633,map01120 C small subunit COG1740 Cluster_200885 V1217085 MAZG map00230,map00240,map01100 F mazG family COG1694 Cluster_335039 V1217086 LPQU M MemBrane-bound lytic murein transglycosylase COG2951 Cluster_219620 V1217087 PPX map00230 F, P ppx gppa phosphatase COG0248 Cluster_399996 V1217088 GABD2 map00010,map00040,map00053,map00071,map00250,map00280,map00310,map00330,map00340,map00350,map00360,map00380,map00410,map00561,map00620,map00625,map00640,map00643,map00650,map00903,map01100,map01110,map01120 C Dehydrogenase COG1012 Cluster_226627 V1217089 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_148078 V1217090 P peroxidase COG2837 Cluster_414355 V1217091 P CopC domain COG2372 Cluster_232423 V1217092 YWQG S Domain of unknown function (DUF1963) COG3878 Cluster_89058 V1217095 S Radical SAM superfamily COG0641 Cluster_442959 V1217096 MT1019 S saf domain-containing protein 122V5 Cluster_365294 V1217097 FTHC map00670,map01100 H 5-formyltetrahydrofolate cyclo-ligase COG0212 Cluster_136684 V1217098 MOEA H Molybdenum cofactor synthesis domain protein COG0303 Cluster_417941 V1217099 RIMJ J N-acetyltransferase COG1670 Cluster_136685 V1217100 MT1025 S conserved transmembrane protein 12614 Cluster_309280 V1217101 S Membrane COG5660 Cluster_256433 V1217102 PMT M glycosyl transferase, family 39 COG1928 Cluster_85912 V1217103 COMM O Mg chelatase subunit ChlI COG0606 Cluster_97878 V1217104 GSPE map03070 U type ii secretion system protein e COG2804 Cluster_579511 V1217105 map02020,map03070 U Prokaryotic N-terminal methylation motif 0ZR0Y Cluster_423371 V1217106 PILD N, O, U Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) COG1989 Cluster_152879 V1217107 S NA 0YCC9 Cluster_32706 V1217111 S RNA ligase COG5324 Cluster_10137 V1217113 S Cell surface protein 0ZXQA Cluster_119122 V1217115 YOCR P transporter COG0733 Cluster_203968 V1217116 GRDB S Selenoprotein B, glycine betaine sarcosine D-proline reductase family 0XPCF Cluster_132641 V1217117 S reductase 0XPPI Cluster_321382 V1217118 YOAP S acetyltransferase, (GNAT) family 0XRCP Cluster_7123 V1217119 SURB S G5 domain protein 0ZVV3 Cluster_355392 V1217122 S NA 12433 Cluster_67522 V1217125 YDCQ D ftsk SpoIIIE family protein COG1674 Cluster_245152 V1217131 RIBF map00740,map01100 H riboflavin biosynthesis protein ribF COG0196 Cluster_34910 V1217132 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_531620 V1217133 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_449002 V1217134 PGSA map00564,map01100 I cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase COG0558 Cluster_187316 V1217135 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_95702 V1217136 SLGD_00064 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_333537 V1217137 map02010 P Cobalt transport protein COG0619 Cluster_152045 V1217138 YCSG P transporter COG1914 Cluster_350553 V1217139 KIPI map00330,map00791,map01100,map01120 E Allophanate hydrolase, subunit 1 COG2049 Cluster_262962 V1217140 MT0276 E urea amidolyase related protein COG1984 Cluster_499768 V1217141 ELAA S gCN5-related N-acetyltransferase COG2153 Cluster_92813 V1217142 PNTB map00760,map01100 C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) COG1282 Cluster_77124 V1217143 map00760,map01100 C NAD(P) transhydrogenase (Alpha subunit COG3288 Cluster_592608 V1217144 BH0416 L Transposase COG3464 Cluster_28763 V1217145 THRC map00260,map00750,map01100,map01120,map01230 E Threonine synthase COG0498 Cluster_160374 V1217146 HOM map00260,map00270,map00300,map01100,map01110,map01120,map01230 E homoserine dehydrogenase COG0460 Cluster_224324 V1217147 ASD map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) COG0136 Cluster_126798 V1217148 YCLM map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Aspartokinase COG0527 Cluster_281704 V1217149 P cation diffusion facilitator family transporter COG0053 Cluster_148821 V1217150 NLPD M peptidase M23 COG0739 Cluster_360417 V1217151 FTSE map02010 D Cell division ATP-binding protein ftsE COG2884 Cluster_279058 V1217152 V (ABC) transporter COG1131 Cluster_170320 V1217153 S Membrane COG0628 Cluster_434886 V1217154 EFP J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) COG0231 Cluster_551891 V1217155 YLQF K Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) COG1161 Cluster_665444 V1217156 RIBH map00740,map01100 H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) COG0054 Cluster_171146 V1217157 RIBD map00740,map01100 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) COG1985 Cluster_341000 V1217158 S membrane 11HPM Cluster_357082 V1217160 J Glutamine amidotransferase COG2071 Cluster_251526 V1217161 E, G EamA-like transporter family COG0697 Cluster_237288 V1217162 MSRA O reductase COG0229 Cluster_142767 V1217164 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_192593 V1217165 PRFA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) COG0216 Cluster_305164 V1217166 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_257716 V1217167 YQHQ J Metal-dependent enzyme COG3872 Cluster_360418 V1217168 O Cytochrome c biogenesis protein COG0785 Cluster_401783 V1217169 S Thioredoxin 12AE3 Cluster_446980 V1217170 RAIA J ribosomal subunit Interface protein COG1544 Cluster_728144 V1217171 S Copper-sensing transcriptional repressor CsoR COG1937 Cluster_27181 V1217172 COPA P p-type ATPase COG2217 Cluster_97354 V1217173 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_456886 V1217174 APT map00230,map01100 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) COG0503 Cluster_554752 V1217175 PEPN map00480,map01100 E aminopeptidase N COG0308 Cluster_385864 V1217176 G SMI1 / KNR4 family (SUKH-1) COG4282 Cluster_382318 V1217177 Q DSBA oxidoreductase 0ZVBB Cluster_130335 V1217178 PQQE K radical SAM domain protein COG0535 Cluster_494598 V1217179 RPIB map00030,map00710,map01100,map01110,map01120,map01230 G Ribose/Galactose Isomerase COG0698 Cluster_264346 V1217180 S NA 11FQQ Cluster_85535 V1217182 BGLA map00460,map00500,map00940,map01100,map01110 G ec 3.2.1.21 COG2723 Cluster_657039 V1217183 G Major Facilitator superfamily 0XP3M Cluster_606780 V1217184 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_165332 V1217185 HEMN map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_53512 V1217186 FADD3 map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG1022 Cluster_31614 V1217187 MALQ map00500,map01100 G 4-alpha-glucanotransferase COG1640 Cluster_636888 V1217189 PADR K Transcriptional regulator COG1695 Cluster_162884 V1217190 PLDB map00561,map00564,map01100,map04723 I Alpha Beta Hydrolase Fold protein COG2267 Cluster_80967 V1217191 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_326023 V1217192 GLPF G glycerol uptake facilitator protein COG0580 Cluster_56499 V1217193 GLPD map00564 C Glycerol-3-phosphate dehydrogenase COG0578 Cluster_492114 V1217194 TRMB C Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_53276 V1217198 PCKG map00010,map00020,map00620,map01100,map01110,map01120,map03320,map04151,map04910,map04920,map04964 C Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) COG1274 Cluster_494599 V1217199 NSRR map05132 K Transcriptional regulator COG1959 Cluster_156101 V1217200 HMP map05132 C nitric oxide dioxygenase (EC 1.14.12.17) COG1018 Cluster_249045 V1217201 map00910 S 2-Nitropropane dioxygenase COG2070 Cluster_133478 V1217202 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_129611 V1217203 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_63181 V1217204 G domain protein 11V8D Cluster_10627 V1217205 S NA 0XPXX Cluster_332047 V1217206 D ftsk SpoIIIE family protein COG1674 Cluster_596091 V1217210 HINDVM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_189017 V1217213 AFTC S integral membrane protein 0XT56 Cluster_449003 V1217217 SPOVK O AAA ATPase, central domain protein COG0464 Cluster_509869 V1217218 FPRA map00250,map00910,map01100,map01110,map01120,map01230 C reductase COG0493 Cluster_315326 V1217219 H cobalamin (vitamin b12) biosynthesis cbix protein COG2138 Cluster_152046 V1217220 CYSN map00230,map00450,map00920,map01100,map01120 P may be the GTPase, regulating ATP sulfurylase activity (By similarity) COG2895 Cluster_245153 V1217221 CYSD map00230,map00450,map00920,map01100,map01120 P sulfate adenylyltransferase), subunit 2 COG0175 Cluster_64574 V1217222 NIRA map00910,map00920,map01100,map01120 C Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) COG0155 Cluster_9809 V1217223 S VWA 11VQQ Cluster_213815 V1217225 M Cell wall anchor domain protein 0YMXG Cluster_316852 V1217226 S ABC, transporter COG1123 Cluster_234891 V1217227 SCLAV_5590 S ABC, transporter 11FMH Cluster_285919 V1217228 DPPC map02010 P ABC transporter COG1173 Cluster_239877 V1217229 DPPB P Binding-protein-dependent transport systems inner membrane component COG0601 Cluster_70235 V1217230 SCLAV_5587 E Extracellular solute-binding protein, family 5 COG0747 Cluster_245154 V1217231 PDXY map00750,map01100 H functions in a salvage pathway. Uses pyridoxamine (By similarity) COG2240 Cluster_520369 V1217232 YAEJ J class I peptide chain release factor COG1186 Cluster_273708 V1217233 YPFJ S zinc metallopeptidase COG2321 Cluster_118399 V1217235 PFLB map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_88116 V1217236 PFLA O Pyruvate formate-lyase COG1180 Cluster_545934 V1217237 S NA 0Y5YX Cluster_275061 V1217238 YIHY S ribonuclease BN COG1295 Cluster_188175 V1217239 K regulatoR COG3835 Cluster_174517 V1217240 GLXK map00260,map00561,map00630,map01100,map01110 G Glycerate kinase COG1929 Cluster_138237 V1217241 GNTT2 E, G gntp family COG2610 Cluster_179497 V1217242 map02010 S ABC-2 type transporter 11HPT Cluster_507282 V1217243 DRAG O ADP-ribosylation crystallin J1 COG1397 Cluster_66576 V1217244 E oligoendopeptidase, m3 family COG1164 Cluster_114876 V1217245 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_279059 V1217246 C nitrilase cyanide hydratase and apolipoprotein n-acyltransferase COG0388 Cluster_80161 V1217248 S Pfam:DUF1023 11GG7 Cluster_156102 V1217249 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_416140 V1217250 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_225503 V1217251 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_199882 V1217252 DINB L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity) COG0389 Cluster_202931 V1217253 S NA 124W6 Cluster_135063 V1217254 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01230 G phosphohexose isomerase COG0166 Cluster_482661 V1217255 COAD map00770,map01100 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) COG0669 Cluster_432964 V1217256 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_40386 V1217257 RECG map03440 L ATP-dependent DNA helicase recg COG1200 Cluster_73147 V1217258 YLOV S dak2 domain fusion protein ylov COG1461 Cluster_785209 V1217259 RPMB map03010 J 50S ribosomal protein l28 COG0227 Cluster_389407 V1217260 THIN map00730,map01100 H thiamine COG1564 Cluster_446981 V1217261 THIT S Proton-coupled thiamine transporter YuaJ COG3859 Cluster_512448 V1217262 NRDR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) COG1327 Cluster_130336 V1217263 RARA L recombination factor protein RarA COG2256 Cluster_109425 V1217264 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_816898 V1217265 XIS S DNA binding domain protein, excisionase family 121Y0 Cluster_296773 V1217266 PROC map00330,map01100,map01110,map01230 E pyrroline-5-carboxylate reductase COG0345 Cluster_102796 V1217267 S Membrane 0XTQ0 Cluster_260343 V1217268 PPX1 map00230 F, P ppx gppa phosphatase COG0248 Cluster_305166 V1217269 RV0495C S NA 0ZV27 Cluster_127488 V1217270 SENX3 map02020 T Histidine kinase 0XNMH Cluster_160375 V1217272 E Aminotransferase COG0436 Cluster_107049 V1217273 ABGB E aminobenzoyl-glutamate utilization protein B COG1473 Cluster_246477 V1217274 GLSA map00250,map00330,map00471,map00910,map01100,map01120,map04724,map04727,map04964 E Glutaminase COG2066 Cluster_380551 V1217275 S Membrane 11U5A Cluster_252740 V1217276 SCLAV_4470 map00561,map01100 S Triacylglycerol lipase COG1075 Cluster_88570 V1217278 S Conserved domain protein 0XZV4 Cluster_124093 V1217280 METY map00270,map01100 E O-Acetylhomoserine COG2873 Cluster_31505 V1217281 ICD map00020,map00480,map00720,map01100,map01110,map01120,map01210,map01230,map04146 C Isocitrate dehydrogenase COG2838 Cluster_126799 V1217283 CG0772 G Major Facilitator COG2814 Cluster_494600 V1217284 PPA map00190 C pyrophosphate phospho-hydrolase COG0221 Cluster_692087 V1217285 P Rhodanese-like domain 121TY Cluster_4653 V1217286 NPSC Q amino acid adenylation domain protein COG1020 Cluster_149587 V1217287 G Major Facilitator COG0477 Cluster_195298 V1217288 S Zinc finger, swim domain protein COG4279 Cluster_17887 V1217289 RV1278 S growth 0ZW9I Cluster_172874 V1217290 map02010 P Periplasmic binding protein COG0614 Cluster_40387 V1217291 GLTB map00250,map00630,map00910,map01100,map01110,map01120,map01230 E Glutamate synthase COG0070 Cluster_284481 V1217292 S Pfam:DUF1994 0XRWZ Cluster_65393 V1217293 FADD2 Q Acyl-CoA synthetase COG0318 Cluster_335040 V1217294 I, Q Short chain dehydrogenase COG1028 Cluster_319899 V1217295 SDH map00240,map01100 L Dehydrogenase COG4221 Cluster_212692 V1217296 P TrkA-N domain protein COG1226 Cluster_352053 V1217297 PURC map00230,map01100,map01110 F SAICAR synthetase COG0152 Cluster_118400 V1217298 PURF map00230,map00250,map01100,map01110 F glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_88117 V1217299 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_140508 V1217300 UVRD2 map03420,map03430 L helicase COG2887 Cluster_8467 V1217301 MT3296 L helicase COG2887 Cluster_183800 V1217302 S NA 11KMG Cluster_84712 V1217303 KATA map00380,map00630,map01110,map04146,map05014 P catalase COG0753 Cluster_487256 V1217305 MNHE P monovalent cation H antiporter subunit E COG1863 Cluster_380552 V1217306 MNHD P subunit D COG0651 Cluster_487257 V1217307 PHAC map00190,map00910,map01100 P Monovalent cation H antiporter subunit C COG1006 Cluster_10168 V1217308 MRPA map00190 P monovalent cation H antiporter subunit A COG2111 Cluster_469335 V1217309 S NA 17B7U@proNOG Cluster_287327 V1217310 UBIE map00340,map00350,map00624,map01120 Q methyltransferase COG0500 Cluster_614089 V1217311 S Cupin 2, conserved barrel domain protein COG1917 Cluster_153651 V1217313 HRRS T Histidine kinase 0XNMH Cluster_191663 V1217314 YXEA map02010 V ABC transporter, permease COG0577 Cluster_377048 V1217315 ORN map03008 A 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) COG1949 Cluster_296774 V1217316 SCLAV_0509 S Cytochrome c oxidase caa3-type, assembly factor ctag-related protein COG3336 Cluster_11281 V1217317 BL03512 M phage tail tape measure protein COG5283 Cluster_105187 V1217318 S NA 0Y87T Cluster_42597 V1217319 YYBT T domain protein COG3887 Cluster_60961 V1217320 LPQB S lipoprotein lpqb 0ZF99 Cluster_185557 V1217323 BMPA S basic membrane COG1744 Cluster_196147 V1217324 POTD map02010 E ABC transporter COG0687 Cluster_824677 V1217325 NRNA J phosphoesterase RecJ domain protein COG0618 Cluster_318421 V1217330 MEPA M peptidase COG0739 Cluster_125408 V1217332 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L DNA polymerase COG0749 Cluster_531621 V1217333 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_256434 V1217334 O Erythromycin esterase COG2312 Cluster_377049 V1217335 T cyclic nucleotide-binding domain protein COG0664 Cluster_69257 V1217336 HCP C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) COG1151 Cluster_91859 V1217337 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_318422 V1217338 S Protein of unknwon function (DUF2893) 10NS1 Cluster_125409 V1217339 S Phage integrase family 0ZK4N Cluster_836121 V1217340 LTRA L reverse transcriptase COG3344 Cluster_55244 V1217341 TRES map00500,map01100 G Trehalose synthase COG0366 Cluster_110741 V1217342 S domain protein COG3428 Cluster_482662 V1217343 S membrane-flanked domain protein COG3402 Cluster_114197 V1217344 I Carboxylesterase COG2272 Cluster_160376 V1217345 FEOB P Ferrous iron transport protein B COG0370 Cluster_246478 V1217346 DAPF map00300,map01100,map01110,map01120,map01230 E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) COG0253 Cluster_145713 V1217347 MT2802 S atpase involved in dna repair 0XNTH Cluster_131892 V1217349 HFLX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COG2262 Cluster_699175 V1217350 RPLW map03010 J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) COG0089 Cluster_391140 V1217351 RPLC map03010 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 Cluster_450977 V1217352 S Membrane 123WC Cluster_28252 V1217353 S Phage infection protein COG1511 Cluster_54751 V1217354 LEUA map00290,map00620,map01100,map01110,map01210,map01230 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) COG0119 Cluster_147284 V1217355 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_56500 V1217356 LMRA V ABC transporter transmembrane region COG1132 Cluster_59588 V1217357 V ABC transporter, ATP-binding protein COG1132 Cluster_492115 V1217358 RMAH K Transcriptional regulator, MarR family 0XUB6 Cluster_444940 V1217359 map00230 F Adenylate cyclase COG1437 Cluster_38833 V1217360 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_296775 V1217361 RPSB map03010 J 30S ribosomal protein S2 COG0052 Cluster_365296 V1217362 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_341001 V1217363 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_434887 V1217364 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_156948 V1217365 ASPC map00250,map00290,map01100,map01110,map01210,map01230 E Aminotransferase COG0436 Cluster_90911 V1217366 SSCG_04100 S YibE F family protein COG5438 Cluster_110055 V1217367 UDGA map00040,map00053,map00500,map00520,map01100,map01110 M Udp-glucose 6-dehydrogenase COG1004 Cluster_401784 V1217368 DCD map00240,map01100 F deoxycytidine triphosphate deaminase COG0717 Cluster_380553 V1217369 T regulatoR COG2197 Cluster_360419 V1217370 T Two-component system sensor kinase COG4564 Cluster_674143 V1217371 XASA E amino acid COG0531 Cluster_80968 V1217372 S fad dependent oxidoreductase COG2509 Cluster_134263 V1217373 S NA 0ZKMT Cluster_261670 V1217374 V (ABC) transporter 0XQRE Cluster_195299 V1217375 T Histidine kinase COG0642 Cluster_224325 V1217376 SP_0986 S Membrane COG2035 Cluster_15364 V1217377 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_94687 V1217378 RPSA map00900,map01100,map01110,map03010 J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) COG0539 Cluster_224326 V1217379 S YbbR-like protein COG4856 Cluster_281706 V1217380 YBBP S TIGR00159 family COG1624 Cluster_199883 V1217381 MBL D Rod shape-determining protein mreb COG1077 Cluster_489615 V1217382 ISPF map00900,map01100,map01110 I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) COG0245 Cluster_353717 V1217383 ISPD map00900,map01100,map01110 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COG1211 Cluster_100011 V1217386 SARE_3718 S Terminase 11NCI Cluster_97879 V1217387 S Phage portal protein, SPP1 Gp6-like 11J8D Cluster_805089 V1217390 S Structural protein 11PKS Cluster_407059 V1217391 MT0948 L resolvase COG2452 Cluster_108181 V1217392 L transposase IS605 OrfB family 0ZUWF Cluster_71232 V1217393 S NA 0ZT45 Cluster_79479 V1217399 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_186479 V1217401 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_61808 V1217402 POXB map00620,map01100 C pyruvate dehydrogenase COG0028 Cluster_489616 V1217403 RIMI S ribosomal-protein-alanine acetyltransferase COG0456 Cluster_603172 V1217404 YEAZ O Peptidase M22 Glycoprotease COG1214 Cluster_350554 V1217405 Q methyltransferase, type 11 COG0500 Cluster_223151 V1217406 S NA 11NX4 Cluster_348934 V1217407 J methyltransferase COG0566 Cluster_353718 V1217408 GPH map00630,map01100,map01110 S HAD-superfamily hydrolase subfamily IA COG0546 Cluster_322949 V1217409 FDHD C Necessary for formate dehydrogenase activity (By similarity) COG1526 Cluster_72481 V1217411 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_132642 V1217413 CCSB O Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) COG1333 Cluster_266983 V1217414 CCDA O cytochrome C biogenesis COG0785 Cluster_456888 V1217415 CCSX O Redoxin domain protein COG0526 Cluster_352054 V1217416 SCLAV_3539 G phosphoglycerate mutase COG0406 Cluster_118401 V1217417 HEML map00860,map01100,map01110 H Glutamate-1-semialdehyde aminotransferase COG0001 Cluster_154452 V1217418 APRE O Peptidase S8 and S53 subtilisin kexin sedolisin COG4412 Cluster_150447 V1217419 map02010 V (ABC) transporter COG1132 Cluster_382320 V1217420 PA5115 Q Methyltransferase 11IAU Cluster_130337 V1217421 PIP map00330 L Prolyl aminopeptidase COG0596 Cluster_184677 V1217422 S Membrane COG2860 Cluster_410674 V1217423 map00230 K, T Metal Dependent Phosphohydrolase COG0317 Cluster_182082 V1217424 YFMJ map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120 S Alcohol dehydrogenase zinc-binding domain protein COG2130 Cluster_342523 V1217425 G Major Facilitator superfamily 0XQFH Cluster_40546 V1217426 RV2345 S conserved transmembrane protein 11FRB Cluster_131121 V1217427 DGT map00230 F deoxyguanosinetriphosphate triphosphohydrolase-like protein COG0232 Cluster_471480 V1217428 BMUL_2753 F ribonuclease COG4290 Cluster_237289 V1217429 DNAG map03030 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 Cluster_253996 V1217430 NAGK G BadF BadG BcrA BcrD COG2971 Cluster_338115 V1217432 SLGD_00063 map02010 P Cobalt transport protein COG0619 Cluster_93745 V1217433 map02010 P ABC transporter COG1122 Cluster_60651 V1217434 V ABC transporter transmembrane region COG1132 Cluster_58543 V1217435 V ABC transporter COG1132 Cluster_35833 V1217436 F ATP cone domain COG1328 Cluster_231263 V1217437 M polysaccharide deacetylase COG0726 Cluster_162038 V1217438 CTPA M Carboxyl-terminal protease COG0793 Cluster_373564 V1217439 S NA 102FF Cluster_280361 V1217440 RBSK map00030 G ribokinase COG0524 Cluster_389408 V1217441 S NA 103AZ Cluster_280362 V1217442 map02010 P ABC transporter, permease COG1175 Cluster_91860 V1217443 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_252741 V1217445 USPA4 T Universal stress protein COG0589 Cluster_187317 V1217446 INO1 map00521,map00562,map01100,map01110 I synthase COG1260 Cluster_257717 V1217447 map00550,map01100 M glycosyl transferase, family 51 COG0744 Cluster_162039 V1217448 D Chromosome segregation protein SMC COG1196 Cluster_80580 V1217449 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_183801 V1217452 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_312249 V1217453 SURE map00230,map00240,map00760,map01100,map01110 F Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) COG0496 Cluster_307862 V1217454 VICX map03013 S domain protein COG1235 Cluster_279060 V1217455 S YycH protein 0ZZRJ Cluster_152880 V1217457 NATB C, P ABC transporter, permease COG1668 Cluster_161207 V1217458 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_867878 V1217459 SELB map00450,map00970 J Selenocysteine-specific translation elongation factor COG3276 Cluster_59073 V1217461 S NA 0Y392 Cluster_174518 V1217462 S NA 11M61 Cluster_221968 V1217463 YFEH G Bile acid COG0385 Cluster_401785 V1217464 TRPP S Membrane COG5658 Cluster_110056 V1217465 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_35429 V1217466 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_523147 V1217467 USPA3 T Universal stress protein COG0589 Cluster_303659 V1217471 map03420,map03430 L helicase COG3973 Cluster_266984 V1217472 YPUA S secreted protein COG4086 Cluster_408814 V1217474 E, H Thiamine pyrophosphate COG0028 Cluster_97355 V1217475 THRC map00260,map00750,map01100,map01120,map01230 E threonine synthase COG0498 Cluster_146511 V1217476 DCTP C symporter COG1301 Cluster_105805 V1217477 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_144966 V1217478 PTSI map02060 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) COG1080 Cluster_184678 V1217479 YKFB M mandelate racemase muconate lactonizing COG4948 Cluster_289977 V1217480 map00311,map00312,map01110,map02020 V Beta-lactamase COG2367 Cluster_363555 V1217482 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_238603 V1217483 RLUD J Pseudouridine synthase COG0564 Cluster_365297 V1217484 LYTB map00511 G endo-beta-N-acetylglucosaminidase COG4193 Cluster_357083 V1217485 NUC L nuclease COG1525 Cluster_232424 V1217486 YPUA S secreted protein COG4086 Cluster_97356 V1217487 T Histidine kinase 0XNMH Cluster_138238 V1217488 PRIA map03440 L Primosomal protein n' COG1198 Cluster_176950 V1217489 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_134264 V1217490 COABC map00770,map01100 H Phosphopantothenoylcysteine decarboxylase COG0452 Cluster_425157 V1217491 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG0194 Cluster_91861 V1217492 ACCD map00061,map00253,map00620,map00640,map00720,map01100,map01110,map01120 I carboxyl transferase COG0825 Cluster_257718 V1217494 RLUD J pseudouridine synthase COG0564 Cluster_192594 V1217495 MT3294 P TrkA-N domain protein COG1226 Cluster_414356 V1217496 S Metal Dependent Phosphohydrolase COG2316 Cluster_748085 V1217497 PAP L polyphosphate kinase 2 COG2326 Cluster_444941 V1217498 PAP L polyphosphate kinase 2 COG2326 Cluster_68560 V1217499 META map00270,map00920,map01100,map01110,map01230 E Homoserine O-transsuccinylase COG1897 Cluster_440945 V1217500 LPLA map00785,map01100 H Lipoate-protein ligase COG0095 Cluster_542987 V1217501 S DNA-binding protein with PD1-like DNA-binding motif COG1661 Cluster_489617 V1217502 YCIA map00903,map01040 I thioesterase Superfamily protein COG1607 Cluster_30582 V1217503 DNAQ map03022,map03420 L helicase COG1199 Cluster_205043 V1217504 LDCA V peptidase U61 LD-carboxypeptidase A COG1619 Cluster_90421 V1217505 GLCD map00620,map00630,map01100,map01110,map01120 C FAD linked oxidase domain-containing protein COG0277 Cluster_617863 V1217506 LRGA map02020 S lrga family COG1380 Cluster_162040 V1217507 THII map00730,map01100,map04122 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) COG0301 Cluster_175331 V1217508 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_401786 V1217510 S membrane 11UQ3 Cluster_589242 V1217511 map03070 U NA 0ZZV9 Cluster_115559 V1217513 K Inherit from COG: Transcriptional regulator COG2508 Cluster_178622 V1217514 S NA 1030P Cluster_281707 V1217516 MSHB S Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) COG2120 Cluster_39148 V1217517 LPQW E Extracellular solute-binding protein, family 5 COG0747 Cluster_47868 V1217518 TYPA T gtp-binding protein typa COG1217 Cluster_450978 V1217519 S NA 120AV Cluster_12796 V1217522 RV3193C S UPF0182 protein COG1615 Cluster_211608 V1217523 RESC O cytochrome C COG0755 Cluster_266985 V1217524 RFBA map00521,map00523,map01100,map01110 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) COG1209 Cluster_606782 V1217526 S Membrane 0Y2N2 Cluster_166140 V1217527 SCLAV_3679 S Alpha beta hydrolase fold COG0596 Cluster_196960 V1217529 S Acyltransferase family 12D68 Cluster_29303 V1217531 SECA2 map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_321383 V1217532 MERR1 K merr family transcriptional regulator COG0789 Cluster_408815 V1217533 RV1829 S nuclease activity COG1259 Cluster_108182 V1217534 U type iv secretory pathway vird4 protein-like protein 0YII6 Cluster_6568 V1217537 DPNA L helicase COG4646 Cluster_211609 V1217539 M polysaccharide deacetylase COG0726 Cluster_178623 V1217540 METE map00270,map00450,map01100,map01110,map01230 E Methionine synthase COG0620 Cluster_39301 V1217541 FUSA2 J Translation elongation factor COG0480 Cluster_332048 V1217542 MUTM map03410 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) COG0266 Cluster_336571 V1217543 RNC map03008,map05205 K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) COG0571 Cluster_432965 V1217544 YLBN S metal-binding protein COG1399 Cluster_319900 V1217545 RV2927C D growth COG3599 Cluster_34635 V1217546 RECG map03440 L ATP-dependent DNA helicase RecG COG1200 Cluster_596093 V1217547 RRGB M Lpxtg-motif cell wall anchor domain protein 0XSEP Cluster_1999 V1217548 CAFA map03018 J ribonuclease COG1530 Cluster_17294 V1217549 S Rib/alpha-like repeat 10008 Cluster_143465 V1217550 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_475729 V1217551 PURN map00230,map00670,map01100,map01110 F phosphoribosylglycinamide formyltransferase COG0299 Cluster_477934 V1217552 RUVC map03440 L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) COG0817 Cluster_217332 V1217553 ASNA map00250,map00460,map00910,map01100,map01110,map01230 E asparagine synthetase A COG2502 Cluster_265673 V1217558 S Protein of unknown function (DUF3102) 11VGJ Cluster_242526 V1217565 YQAJ L phage-type endonuclease COG5377 Cluster_259041 V1217566 RECT L recT protein COG3723 Cluster_396548 V1217567 S Phage replisome organizer 0ZW0Q Cluster_59883 V1217570 FADH map00633,map01120 C NADH flavin oxidoreductase NADH oxidase COG1902 Cluster_473594 V1217571 OGT L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) COG0350 Cluster_259042 V1217572 P cation diffusion facilitator family transporter COG0053 Cluster_99484 V1217573 HRPB L ATP-dependent helicase COG1643 Cluster_86819 V1217574 map03440 K Transcriptional regulator COG2865 Cluster_149588 V1217575 HSDS V type I restriction-modification system COG0732 Cluster_475730 V1217576 S Toxin-antitoxin system, toxin component, Fic family COG3943 Cluster_436936 V1217577 S DNA-binding protein COG3943 Cluster_257719 V1217578 HSDM V type I restriction-modification system COG0286 Cluster_391141 V1217579 CKL_0494 L transposase COG2801 Cluster_665445 V1217580 S Inherit from NOG: Toxin-antitoxin system, toxin component, RelE family 0Y0E0 Cluster_122152 V1217581 PBUX F permease COG2233 Cluster_38492 V1217582 T Histidine kinase COG0642 Cluster_277699 V1217584 L Dna topoisomerase COG0550 Cluster_517818 V1217585 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_190744 V1217586 PRFA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) COG0216 Cluster_237290 V1217587 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_382321 V1217588 SUA5 J sua5 ycio yrdc ywlc family protein COG0009 Cluster_144215 V1217589 RFE M Glycosyl transferase, family 4 COG0472 Cluster_398275 V1217590 RECX S Modulates RecA activity (By similarity) COG2137 Cluster_714953 V1217591 YAZA L domain protein COG2827 Cluster_614091 V1217592 RPLT map03010 J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) COG0292 Cluster_321384 V1217593 SPOU J rrna methyltransferase COG0566 Cluster_358753 V1217594 S NA 0ZVJP Cluster_471481 V1217595 S NA 0Z63U Cluster_48071 V1217596 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_497104 V1217597 L CT1975-like protein 0YBWR Cluster_449004 V1217598 L CRISPR-associated protein Cse2 (CRISPR_cse2) 0ZD9H Cluster_127490 V1217599 S NA 0YA7V Cluster_414357 V1217600 L CRISPR-Associated Protein 11NWW Cluster_20846 V1217601 CAS3 L CRISPR-associated helicase, cas3 COG1203 Cluster_14638 V1217603 EGYY_05010 U traE protein COG3451 Cluster_141263 V1217606 PITB P phosphate COG0306 Cluster_299458 V1217607 LIPB map00785,map01100 H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) COG0321 Cluster_195300 V1217608 LIPA map00785,map01100 H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) COG0320 Cluster_310719 V1217609 RV2219 S integral membrane protein 0Z3WW Cluster_72821 V1217610 P transport protein COG2985 Cluster_820697 V1217611 CG2428 S rdd domain containing protein 11WIF Cluster_371947 V1217612 ZNUC map02010 P (ABC) transporter COG1121 Cluster_237291 V1217613 ZNUA map02010 P periplasmic solute binding protein COG0803 Cluster_563695 V1217616 S Uncharacterised protein family (UPF0150) 0ZXU8 Cluster_373565 V1217617 BMUL_3003 S Membrane COG3619 Cluster_382322 V1217618 S NA 11XPU Cluster_104594 V1217619 V HNHc 0ZNS5 Cluster_540110 V1217620 SCLAV_4550 L UPF0102 protein COG0792 Cluster_84282 V1217621 COMM O Mg chelatase subunit ChlI COG0606 Cluster_432966 V1217622 P Chromate COG2059 Cluster_210469 V1217623 FECB map02010 P transport system permease protein COG0609 Cluster_368615 V1217624 BMUL_5652 L Transposase COG2801 Cluster_412491 V1217625 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_157813 V1217626 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_61809 V1217627 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_188176 V1217628 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_62084 V1217629 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_57022 V1217630 CAFA map03018 J ribonuclease COG1530 Cluster_414358 V1217631 ARSM map00130,map00340,map00350,map00624,map01100,map01110,map01120 S methyltransferase, type 11 0XSKB Cluster_678594 V1217632 K transcriptional regulator 11VCW Cluster_238604 V1217633 JAG S Single-stranded nucleic acid binding R3H domain-containing protein COG1847 Cluster_41382 V1217634 L adenine specific DNA methylase COG2189 Cluster_432967 V1217635 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_116288 V1217636 TILS D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) COG0037 Cluster_540111 V1217637 YABR J RNA binding s1 domain protein COG1098 Cluster_260344 V1217639 J HAD-superfamily hydrolase subfamily IA variant 3 COG0637 Cluster_221969 V1217640 PHOH T Phoh family COG1702 Cluster_504699 V1217641 YBEY map00240,map00983,map01100 F Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) COG0319 Cluster_389409 V1217642 S NA 11VIE Cluster_266986 V1217644 RLUC2 J pseudouridine synthase COG0564 Cluster_18859 V1217645 SCLAV_2230 V ABC, transporter COG0577 Cluster_520371 V1217646 S Short-chain dehydrogenase reductase sdr COG0300 Cluster_336572 V1217647 S NA 0ZCBM Cluster_6921 V1217648 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit alpha COG0587 Cluster_130338 V1217649 ILVA map00260,map00290,map01100,map01110,map01230 E Threonine dehydratase COG1171 Cluster_288681 V1217650 S NA 0ZN4K Cluster_184679 V1217651 S ABC transporter, ATPase COG3044 Cluster_306555 V1217652 TIPA K Transcriptional regulator COG0789 Cluster_307863 V1217654 NAGB map00520,map01100,map01110 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COG0363 Cluster_335041 V1217655 O ADP-ribosylation crystallin J1 COG1397 Cluster_781085 V1217656 S Protein of unknown function (DUF1648) 0YVE4 Cluster_51921 V1217657 L recombinase COG1961 Cluster_345741 V1217658 T Regulator COG0745 Cluster_13211 V1217659 ADDA L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation COG1074 Cluster_305167 V1217660 PLSC map00561,map00564,map01100 I Acyl-transferase COG0204 Cluster_167676 V1217661 PIMB M Glycosyl transferase (Group 1 COG0438 Cluster_208351 V1217662 CG2401 M Secreted protein COG0791 Cluster_212693 V1217663 S CAAX amino terminal protease family 0ZWQM Cluster_16938 V1217664 P ATPase, P-type transporting, HAD superfamily, subfamily IC COG0474 Cluster_504700 V1217666 CTSR K transcriptional regulator, ctsr COG4463 Cluster_152882 V1217667 APEB E M18 family aminopeptidase COG1362 Cluster_221970 V1217669 S Htaa 11VMG Cluster_137475 V1217670 THIC map00730,map01100 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) COG0422 Cluster_45569 V1217671 NTPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_403562 V1217679 DCM map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_762247 V1217680 S NA 0Y0CD Cluster_98963 V1217681 UMUC L ImpB MucB SamB family protein COG0389 Cluster_444942 V1217682 S Toxin-antitoxin system, toxin component 0XRRU Cluster_557675 V1217683 K DNA-binding helix-turn-helix protein 11XIQ Cluster_367002 V1217685 map02010 S YodA lipocalin-like domain 11KBP Cluster_103421 V1217686 AGCS E amino acid carrier protein COG1115 Cluster_73512 V1217687 HCP C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) COG1151 Cluster_289978 V1217688 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_136686 V1217689 SUN J ribosomal RNA small subunit methyltransferase COG0144 Cluster_197892 V1217690 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_83391 V1217691 S Domain of unknown function (DUF222) 11KRE Cluster_287328 V1217692 map00270,map01100,map04122 P sulfurtransferase COG2897 Cluster_45953 V1217693 MT0396 S Secreted protein 11RTG Cluster_526069 V1217694 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_124745 V1217696 PEPD map02020 O Peptidase s1 and s6 chymotrypsin hap COG0265 Cluster_80969 V1217697 MPRB map02020 T Histidine kinase COG0642 Cluster_230088 V1217699 MRAY map00550,map01100 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) COG0472 Cluster_123460 V1217700 MURD map00471,map00550,map01100 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COG0771 Cluster_180321 V1217701 FTSW map04112 D cell division protein COG0772 Cluster_179498 V1217702 MURG map00550,map01100,map04112 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) COG0707 Cluster_339548 V1217703 FTSQ map04112 M domain protein, FtsQ-type COG1589 Cluster_596094 V1217704 TNPR L Resolvase COG1961 Cluster_299459 V1217705 STRA J Aminoglycoside COG3231 Cluster_284482 V1217706 STRB V aminoglycoside hydroxyurea antibiotic resistance kinase COG3570 Cluster_162041 V1217707 G Chloramphenicol resistance protein COG2814 Cluster_427090 V1217708 L resolvase COG1961 Cluster_589244 V1217709 GRDX S grdx protein 1230X Cluster_105188 V1217710 SELA map00450,map00970 E Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) COG1921 Cluster_173710 V1217711 S Inherit from COG: Membrane COG3949 Cluster_160377 V1217712 HOM map00260,map00270,map00300,map01100,map01110,map01120,map01230 E homoserine dehydrogenase COG0460 Cluster_225504 V1217713 ASD map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) COG0136 Cluster_126800 V1217714 YCLM map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Aspartokinase COG0527 Cluster_95703 V1217716 GLNA map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG0174 Cluster_162885 V1217717 OCD map00270,map00330,map00920,map01100,map01110,map01120,map01230 E Ornithine Cyclodeaminase COG2423 Cluster_99485 V1217718 GLNA map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG0174 Cluster_11534 V1217721 SCLAV_2624 S NA 0YQAJ Cluster_603173 V1217722 S NA 0YJ8K Cluster_378824 V1217724 VANZ V VanZ-like protein COG4767 Cluster_699176 V1217725 HYPD O hydrogenase expression formation protein HypD COG0409 Cluster_272377 V1217726 CITE map00020,map01110,map02020 G Citrate lyase COG2301 Cluster_60141 V1217727 FADD35 map00071,map01100,map03320,map04146,map04920 Q Amp-dependent synthetase and ligase COG0318 Cluster_196961 V1217728 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_114198 V1217729 MURF map00300,map00550,map01100 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) COG0770 Cluster_360420 V1217730 YDJZ S SNARE associated Golgi protein-related protein COG0398 Cluster_138239 V1217731 GLTP C Transporter, dicarboxylate amino acid cation Na H symporter family protein COG1301 Cluster_440946 V1217732 TRPP S tryptophan transport protein 11UPK Cluster_313739 V1217733 UDP map00240,map00983,map01100 F Uridine phosphorylase COG2820 Cluster_333538 V1217734 RLMB map00340,map00350,map00624,map01120 J RNA methyltransferase TrmH family group 3 COG0566 Cluster_97880 V1217735 AMYA map00500,map01100,map04973 G Alpha-amylase COG0366 Cluster_403563 V1217736 RNHA map03030 S ribonuclease COG3341 Cluster_192595 V1217737 NUOG map00190,map00630,map00680,map00910,map01100,map01120 C oxidoreductase COG3383 Cluster_245155 V1217738 C NADH-ubiquinone oxidoreductase-G iron-sulfur binding region COG3383 Cluster_50158 V1217739 HYMB map00190,map00910,map01100 C NADH dehydrogenase COG1894 Cluster_484985 V1217740 NUOE map00190,map00910,map01100 C NADH dehydrogenase (Ubiquinone), 24 kDa subunit COG1905 Cluster_299460 V1217742 S Calcineurin-like phosphoesterase COG1408 Cluster_114199 V1217744 PYCB map00330,map00620,map01100 C Oxaloacetate decarboxylase COG5016 Cluster_41383 V1217747 U TraG family COG3505 Cluster_477935 V1217748 RIBX S Pfam:DUF2581 11VXH Cluster_196962 V1217749 RIBD map00740,map01100 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) COG1985 Cluster_368617 V1217750 RPE map00030,map00040,map00710,map01100,map01110,map01120,map01230 G ribulose-phosphate 3-epimerase COG0036 Cluster_83392 V1217752 ERIC P Chloride channel COG0038 Cluster_345742 V1217755 SRTA M (sortase) family COG3764 Cluster_385866 V1217761 RIMJ J N-acetyltransferase COG1670 Cluster_186480 V1217764 BL01373 L Integrase COG0582 Cluster_403564 V1217766 K Peptidase S24-like COG1974 Cluster_185558 V1217769 MURE map00300,map00550 M mur ligase COG0769 Cluster_233691 V1217771 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_135876 V1217772 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_280364 V1217773 PDXS map00750 H Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) COG0214 Cluster_327589 V1217774 CAUL_2856 map00051,map00140,map00363,map00591,map00625,map00650,map01100,map01120 S Short-chain dehydrogenase reductase Sdr COG1028 Cluster_103999 V1217775 GND map00030,map00480,map01100,map01110,map01120 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) COG0362 Cluster_105806 V1217777 S secreted peptidase 0Z6A1 Cluster_75164 V1217778 YEJH L type iii restriction protein res subunit COG1061 Cluster_318423 V1217779 Y3088 S regulatory prophage protein 16SGX@proNOG Cluster_13494 V1217780 Y3088 S regulatory prophage protein 16SGX@proNOG Cluster_540112 V1217781 FRUA map00051,map01100,map02060 G PTS System COG1762 Cluster_119123 V1217782 F Uracil permease COG2233 Cluster_170321 V1217783 MRPA map00190 P monovalent cation H antiporter subunit A COG2111 Cluster_114200 V1217785 GSPE map03070 U type ii secretion system protein e COG2804 Cluster_271046 V1217786 DKGA C reductase COG0656 Cluster_473595 V1217787 S ABC transporter COG4152 Cluster_384100 V1217788 NBCG_03603 S Protein of unknown function (DUF3027) 11G10 Cluster_15263 V1217791 ELRF S cutinase 11FQ6 Cluster_242527 V1217793 S Secretion protein snm4 0YE0Q Cluster_119124 V1217794 HLYX P Domain of unknown function DUF21 COG1253 Cluster_41694 V1217795 HPPA map00190 C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for COG3808 Cluster_542989 V1217796 C Flavodoxin COG0716 Cluster_449005 V1217797 NTPF S H -ATPase, subunit H 122TR Cluster_342525 V1217798 RNC map03008,map05205 K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) COG0571 Cluster_226628 V1217799 PLSX map00561,map00564,map01100 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) COG0416 Cluster_160378 V1217800 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_415802 V1021601 RNFE C Electron transport complex COG4660 Cluster_345418 V1021604 GLNE O, T Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) COG1391 Cluster_397951 V1021607 YCGM map00350,map01100,map01120 Q fumarylacetoacetate (faa) hydrolase COG0179 Cluster_430576 V1021610 MAF D MAF-like protein COG0424 Cluster_231053 V1021611 K RNA polymerase sigma-24 subunit, ECF subfamily 0ZKQ9 Cluster_428589 V1021622 LGAS_0609 S Phage minor structural protein GP20 123J7 Cluster_419282 V1021625 FKPB O peptidylprolyl cis-trans isomerase COG0545 Cluster_226423 V1021626 map02010 E PBPb COG0834 Cluster_436503 V1021629 S NA 11RDA Cluster_875047 V1021630 V Eco57I restriction-modification methylase COG1002 Cluster_321096 V1021632 LYTT map02020 T regulatoR COG3279 Cluster_895403 V1021633 LRGA map02020 S murein hydrolase regulator LrgA COG1380 Cluster_496545 V1021634 S lysozyme 0YC6U Cluster_484466 V1021635 S conjugative transposon protein TraQ 11SF8 Cluster_381955 V1021639 K Tetr family transcriptional regulator 11PAC Cluster_217107 V1021642 RECQ map03018 L ATP-dependent DNA helicase RecQ COG0514 Cluster_819697 V1021644 TNP3509A L Transposase for insertion sequence element 0Z3DP Cluster_406709 V1021646 RIBE map00740,map01100 H riboflavin synthase, subunit alpha COG0307 Cluster_128758 V1021647 S NA 1202A Cluster_698511 V1021652 S Protein of unknown function (DUF713) 0Y5I3 Cluster_908192 V1021653 SASC S surface protein 11FPX Cluster_261437 V1021654 SASC S surface protein 11FPX Cluster_285632 V1021655 SANA S SanA protein COG2949 Cluster_193278 V1021656 PURM map00230,map01100,map01110 F phosphoribosylaminoimidazole synthetase COG0150 Cluster_464690 V1021657 S NA 11USQ Cluster_188872 V1021661 L UvrD REP helicase COG0210 Cluster_413990 V1021663 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_528240 V1021664 S NA 0YSBG Cluster_299215 V1021665 CBIO1 map02010 P Abc transporter COG1122 Cluster_180168 V1021666 VIOA map00362,map00363,map00626,map00650,map00903,map01100,map01110,map01120 E DegT DnrJ EryC1 StrS COG0399 Cluster_501735 V1021670 RSMI G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 Cluster_460463 V1021672 RPSE map03010 J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) COG0098 Cluster_602320 V1021673 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_743924 V1021675 S NA 0ZHU9 Cluster_499198 V1021677 S Domain of unknown function (DUF1896) 11Y7P Cluster_331778 V1021681 map02010 V transporter COG0842 Cluster_424783 V1021682 ADK map00230,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_132496 V1021683 CLFA map05150 M Cell surface-associated protein implicated in virulence. Promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen. Induces formation of bacterial clumps 0Y59N Cluster_591853 V1021685 YOHJ S lrga family COG1380 Cluster_324229 V1021688 S NA 11PBC Cluster_289767 V1021689 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_281467 V1021691 RLUB J pseudouridine synthase COG1187 Cluster_164345 V1021692 DESA3 map00591,map01100 I Fatty Acid Desaturase COG3239 Cluster_134122 V1021693 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_613267 V1021694 AZO1 map00740,map01100 S Nadph-dependent fmn reductase COG0431 Cluster_575676 V1021696 S NA 11SIY Cluster_578761 V1021699 QUEC map00790,map01100 S Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) COG0603 Cluster_419283 V1021703 S NA 0ZHU9 Cluster_737193 V1021704 S NA 0XW3Z Cluster_353444 V1021705 S acidPPc 11ME9 Cluster_334726 V1021707 FTSE map02010 D Cell division ATP-binding protein ftsE COG2884 Cluster_145579 V1021708 M exopolysaccharide biosynthesis COG0489 Cluster_486780 V1021709 S membrane 11PB2 Cluster_181866 V1021710 BGAA map00052,map00511,map00600,map01100 G hydrolase, family 2 COG3250 Cluster_569254 V1021714 S NA 17D58@proNOG Cluster_253793 V1021715 S Pfam:DUF1812 0Y61M Cluster_260127 V1021716 QCRC map00190,map01100 C cytochrome C COG2010 Cluster_695142 V1021717 QCRA map00190,map00910,map01100,map02020,map04260,map05010,map05012,map05016 C c reductase, iron-sulfur COG0723 Cluster_243647 V1021718 L integrase family 0ZJHZ Cluster_454551 V1021719 S single-strand binding family protein 0XS6K Cluster_506672 V1021720 S NA 0ZEMC Cluster_769163 V1021721 GMD map00051,map00520,map01100 M Gdp-mannose 4,6-dehydratase COG1089 Cluster_360088 V1021722 BMUL_1176 S Peptidase M50 COG1994 Cluster_199689 V1021730 RC1_2786 L transposase COG5433 Cluster_176826 V1021731 MRPA map00190 P monovalent cation H antiporter subunit A COG2111 Cluster_136538 V1021732 map00020,map00310,map00380,map01100,map01110,map01120 C 2-oxoglutarate dehydrogenase, E1 subunit COG0567 Cluster_135737 V1021733 U, W Pfam:YadA COG5295 Cluster_747354 V1021734 FEOA P Ferrous iron transport protein A COG1918 Cluster_300550 V1021736 PHNB map02010 P phosphonate abc transporter COG3639 Cluster_136539 V1021737 HSDR V type I restriction-modification system COG0610 Cluster_479823 V1021740 MRA_2194 S NA 11IRB Cluster_473121 V1021741 MMSA map00280,map00410,map00562,map00640,map01100 I methylmalonate-semialdehyde dehydrogenase COG1012 Cluster_192442 V1021742 AARI_34710 L Transposase for insertion sequence 11IYJ Cluster_136540 V1021743 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_460464 V1021744 ISPF map00900,map01100,map01110 I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) COG0245 Cluster_137318 V1021748 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_202720 V1021749 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin 0XQTW Cluster_602321 V1021750 S NA 11SYG Cluster_287056 V1021752 CKL_0494 L transposase COG2801 Cluster_727358 V1021753 BBAL3_2090 L transposase COG2801 Cluster_442549 V1021755 K Tetr family transcriptional regulator 11SFF Cluster_213603 V1021756 COBT map00860,map01100 H Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) COG2038 Cluster_528241 V1021759 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_310434 V1021763 COBA map00860,map01100,map01110 H Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) COG0007 Cluster_380174 V1021766 ACNA map00020,map00300,map00630,map00720,map01100,map01110,map01120,map01210,map01230 C aconitate hydratase COG1048 Cluster_542258 V1021767 ARSC P arsenate reductase COG1393 Cluster_714236 V1021768 NRDA map00230,map00240,map00480,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_701612 V1021769 GALF_0732 L transposase, IS3 IS911 family protein 17PD7@proNOG Cluster_624493 V1021770 RPIC_1486 L IS66 Orf2 family protein 17EQY@proNOG Cluster_509299 V1021774 HSLR J Heat shock protein COG1188 Cluster_277459 V1021780 S NA 11KFV Cluster_904009 V1021783 S NA 0ZHU9 Cluster_450565 V1021784 RV1481 S von Willebrand factor, type A COG2304 Cluster_536674 V1021785 RV1480 S von Willebrand factor COG1721 Cluster_278837 V1021786 S Protein of unknown function (DUF2807) 0ZWQJ Cluster_221784 V1021787 S NA 0ZKFH Cluster_754163 V1021788 map03420,map03430 L helicase COG3973 Cluster_475250 V1021789 COAD map00770,map01100 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) COG0669 Cluster_295161 V1021790 NQRC C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG2869 Cluster_448586 V1021791 RBR C Rubrerythrin COG1592 Cluster_238355 V1021792 FLGJ map00511 N, U flagellar rod assembly protein muramidase flgj COG1705 Cluster_442550 V1021795 RIMM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) 11M4J Cluster_289768 V1021796 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_695143 V1021797 S Transglycosylase associated protein COG2261 Cluster_410676 V1217801 PLSY map00561,map00564,map01100 S Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) COG0344 Cluster_800883 V1217803 L Dna topoisomerase COG0550 Cluster_107050 V1217804 S NA 0Z34Z Cluster_62630 V1217806 MOP map00230,map01100,map01120 C Xanthine dehydrogenase COG2080 Cluster_26892 V1217807 PRIA map03440 L Primosomal protein n' COG1198 Cluster_669755 V1217808 S NA 11JEI Cluster_108183 V1217809 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_241154 V1217810 YHCC S Radical SAM Protein COG1242 Cluster_531622 V1217811 S NA 121S9 Cluster_21406 V1217814 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_614092 V1217815 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_566887 V1217816 RPSH map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) COG0096 Cluster_127491 V1217817 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_291290 V1217818 BMUL_5652 L Transposase COG2801 Cluster_34351 V1217820 S Lpxtg-motif cell wall anchor domain protein 0XQBH Cluster_425158 V1217821 YQEK map00760,map01100 H Metal Dependent Phosphohydrolase COG1713 Cluster_419712 V1217822 S integral membrane protein 11P1U Cluster_714954 V1217823 map00630,map01100 G Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) COG3622 Cluster_335042 V1217824 OCAR_5505 S Short-chain dehydrogenase reductase Sdr 0XNT1 Cluster_146512 V1217825 ENTC map00130,map01053,map01100,map01110 H Isochorismate synthase COG1169 Cluster_306556 V1217826 FAHA Q 5-carboxymethyl-2-hydroxymuconate Delta-isomerase (EC 5.3.3.10) COG0179 Cluster_77125 V1217827 VP1725 T cbs domain and cyclic nucleotide-regulated nucleotidyltransferase COG2905 Cluster_165333 V1217828 S NA 0Z6MD Cluster_341002 V1217829 S Filamentation induced by cAMP protein fic COG3177 Cluster_16440 V1217830 S s-layer domain-containing protein 11ZJU Cluster_193480 V1217831 CSAB M Polysaccharide pyruvyl transferase COG2327 Cluster_394763 V1217832 MSHD S Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) COG0456 Cluster_183802 V1217833 PSTS map02010,map02020,map05152 P Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) COG0226 Cluster_188177 V1217835 M glycosyl transferase group 1 COG0438 Cluster_161208 V1217836 PGLE E DegT DnrJ EryC1 StrS aminotransferase COG0399 Cluster_382324 V1217838 PGLB M sugar transferase COG2148 Cluster_446982 V1217839 map00350,map00362,map00627,map00642,map00903,map01120 S Transferase COG0110 Cluster_2435 V1217840 S NA 101UU Cluster_65103 V1217841 CRTI map00906,map01100,map01110 Q phytoene COG1233 Cluster_179499 V1217842 IDSA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_245156 V1217843 METF map00670,map00720,map01100,map01120 E Methylenetetrahydrofolate reductase COG0685 Cluster_405372 V1217844 LPPM S (LipO)protein 11TZC Cluster_32707 V1217845 F ATP cone domain COG1328 Cluster_103422 V1217846 S Pfam:DUF571 101QY Cluster_144967 V1217847 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_487258 V1217848 map00190,map00910,map01100 C hydrogenase) (Fe-only COG4624 Cluster_171966 V1217849 S YibE F family protein COG5438 Cluster_239878 V1217851 OPPF map02010 E ABC superfamily ATP binding cassette transporter ABC protein COG4608 Cluster_227758 V1217852 OPPB E, P Oligopeptide ABC transporter, permease protein AppB COG0601 Cluster_247738 V1217853 APPC map02010 P ABC superfamily ATP binding cassette transporter ABC protein COG1173 Cluster_13250 V1217854 PITRM1 O peptidase COG1026 Cluster_319901 V1217855 XTH map03410 L Exodeoxyribonuclease III COG0708 Cluster_436938 V1217856 TATB map03060,map03070 U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) COG1826 Cluster_124746 V1217857 HTRA map02020 O Peptidase s1 and s6 chymotrypsin hap COG0265 Cluster_377050 V1217858 SIGE K RNA polymerase COG1595 Cluster_515150 V1217859 SMPB O Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) COG0691 Cluster_61810 V1217860 FBPA K Fibronectin-binding protein COG1293 Cluster_724875 V1217861 YLZA S UPF0296 protein COG2052 Cluster_494601 V1217862 PURE map00230,map01100,map01110 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) COG0041 Cluster_206119 V1217863 PURM map00230,map01100,map01110 F phosphoribosylaminoimidazole synthetase COG0150 Cluster_76424 V1217864 YBIT S ABC transporter, ATP-binding protein COG0488 Cluster_87687 V1217865 GATB map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 Cluster_124747 V1217868 P NA 1834U@proNOG Cluster_269735 V1217869 P Siderophore-interacting protein COG2375 Cluster_7527 V1217870 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_310720 V1217872 map02010 P ABC transporter COG1131 Cluster_387709 V1217873 S integral membrane protein 11PE6 Cluster_107630 V1217874 SCLAV_4353 T Histidine kinase 11H4Z Cluster_367003 V1217875 T Two component transcriptional regulator, LuxR family COG2197 Cluster_271047 V1217876 C radical SAM domain protein COG1032 Cluster_96289 V1217877 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_221971 V1217878 YTQA S Radical SAM Protein COG1242 Cluster_292648 V1217879 HYPD O hydrogenase expression formation protein HypD COG0409 Cluster_171147 V1217880 HYPE O hydrogenase expression formation protein (HypE) COG0309 Cluster_24917 V1217881 HYPF O hydrogenase maturation protein Hypf COG0068 Cluster_399997 V1217882 THIN map00730,map01100 H thiamine COG1564 Cluster_241155 V1217885 S Protein of unknown function (DUF418) 0YAB0 Cluster_300826 V1217887 HISN map00340,map00521,map00562,map01100,map01110,map01230,map04070 E histidinol-phosphate phosphatase COG0483 Cluster_419713 V1217888 SUHB G inositol mono-phosphatase COG0483 Cluster_157814 V1217889 IADA S Isoaspartyl dipeptidase 0XNTK Cluster_287329 V1217890 M (sortase) family COG3764 Cluster_74183 V1217892 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_492117 V1217893 S septicolysin 11TVT Cluster_265674 V1217894 DINB L Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) COG0389 Cluster_371948 V1217895 MAA S maltose O-acetyltransferase COG0110 Cluster_220808 V1217896 ANSA map00250,map00460,map00910,map01100,map01110 E L-asparaginase COG0252 Cluster_329085 V1217897 S secreted protein 0Y4BT Cluster_277700 V1217898 S NA 129E3 Cluster_560740 V1217899 LSPA map03060 M, U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) COG0597 Cluster_378825 V1217900 S Membrane 129XD Cluster_298176 V1217901 TRPC map00400,map01100,map01110,map01230 E Indole-3-glycerol phosphate synthase COG0134 Cluster_145714 V1217902 TRPB map00260,map00400,map01100,map01110,map01230 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) COG0133 Cluster_310721 V1217903 TRPA map00260,map00400,map01100,map01110,map01230 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) COG0159 Cluster_699177 V1217904 LGT M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 Cluster_233692 V1217906 YEDI S Inner membrane protein yedI COG2354 Cluster_231264 V1217907 GUAB1 map00230,map00983,map01100,map01110 F Dehydrogenase COG0517 Cluster_396549 V1217908 RPFA S Resuscitation-promoting factor 11WB2 Cluster_21686 V1217909 MT0885 S NA 0XPFG Cluster_277701 V1217910 ERCC3 map03022,map03420 L helicase COG1061 Cluster_61557 V1217911 PBP2B M penicillin-binding protein COG0768 Cluster_94688 V1217912 COBQ map00860,map01100 H catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) COG1492 Cluster_256435 V1217913 MTR map00010,map00020,map00260,map00280,map00480,map00620,map01100,map01110,map01120 C pyridine nucleotide-disulfide oxidoreductase COG1249 Cluster_313740 V1217914 S NA 0Y8QF Cluster_339549 V1217915 S Multi-copper polyphenol oxidoreductase laccase COG1496 Cluster_180322 V1217916 S repeat protein 11IAG Cluster_182984 V1217917 MT0238 map00350,map00362,map00627,map00642,map00903,map01120 I Acyl-transferase COG1835 Cluster_10628 V1217918 AFTD S coagulation factor 5 8 type domain-containing protein 0YR9E Cluster_352055 V1217919 T Response Regulator COG0745 Cluster_417943 V1217920 PPIB O PPIases accelerate the folding of proteins COG0652 Cluster_389410 V1217921 TDK map00240,map00983,map01100 F thymidine kinase COG1435 Cluster_497105 V1217922 LUXS map00270,map05111 T Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) COG1854 Cluster_182083 V1217923 MRDB M Rod shape-determining protein rodA COG0772 Cluster_285920 V1217924 NFO map03410 L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) COG0648 Cluster_124748 V1217926 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_339550 V1217927 YFIH S Multi-copper polyphenol oxidoreductase laccase COG1496 Cluster_210470 V1217928 D DivIVA protein COG3599 Cluster_288682 V1217929 OCAR_5968 S Protein of unknown function (DUF1009) COG3494 Cluster_103423 V1217931 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_141264 V1217932 S UPF0597 protein COG3681 Cluster_741427 V1217933 MUG map03410 L U mismatch-specific DNA glycosylase COG3663 Cluster_408817 V1217934 PDUO map00860,map01100 S adenosyltransferase COG2096 Cluster_769953 V1217935 O ADP-ribosylation crystallin J1 COG1397 Cluster_77815 V1217936 P Sodium hydrogen exchanger COG4651 Cluster_209399 V1217937 S Ankyrin repeat protein COG0666 Cluster_117712 V1217938 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_61271 V1217940 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_71233 V1217941 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0847 Cluster_387710 V1217942 TREY map00500,map01100,map01110 G malto-oligosyltrehalose synthase COG3280 Cluster_19107 V1217943 RV3401 map00500,map01100 G hydrolase family 65, central catalytic COG1554 Cluster_194418 V1217944 SDHA map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020,map05134 C succinate dehydrogenase, flavoprotein subunit COG1053 Cluster_534405 V1217945 AROQ map00400,map01051,map01100,map01110,map01230 E Catalyzes a trans-dehydration via an enolate intermediate (By similarity) COG0757 Cluster_152047 V1217946 map00400,map01100,map01110,map01230 E shikimate COG0703 Cluster_185559 V1217947 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_156103 V1217948 AROA map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate synthase COG0128 Cluster_2616 V1217949 M domain protein COG4932 Cluster_79789 V1217950 OCAR_6158 L Terminase, large subunit COG4626 Cluster_820698 V1217951 ELI_1297 O phage portal protein HK97 family COG4695 Cluster_326024 V1217952 S Rhodanese-like domain 11QSF Cluster_91862 V1217953 map00680,map01120 S Phosphotransferase 0Y7VB Cluster_236087 V1217954 C iron-sulfur 11G02 Cluster_310722 V1217955 RSME S Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) COG1385 Cluster_205044 V1217956 PHOH T Phoh family COG1702 Cluster_231265 V1217957 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_425159 V1217960 S NA 0Z4GX Cluster_37490 V1217961 M Transglycosylase SLT domain COG0739 Cluster_175332 V1217962 S ATP GTP-binding protein 0XNYD Cluster_348936 V1217963 NUSB K Involved in the transcription termination process (By similarity) COG0781 Cluster_427091 V1217964 PYRR map00240,map01100 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) COG2065 Cluster_233693 V1217965 PYRB map00240,map00250,map01100 F aspartate transcarbamylase COG0540 Cluster_463025 V1217966 PYRC map00240,map01100 F dihydroorotase COG0044 Cluster_548991 V1217967 PROB map00330,map01100,map01230 E Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) COG0263 Cluster_344113 V1217968 SRTA M (sortase) family COG3764 Cluster_373566 V1217969 GPMB map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_266987 V1217970 PSTA map02010 P phosphate abc transporter COG0581 Cluster_324524 V1217971 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_375281 V1217972 PHOU P Plays a role in the regulation of phosphate uptake COG0704 Cluster_64841 V1217973 PHOR map02020 T Histidine kinase 0XNMH Cluster_102252 V1217974 HYDG map00730,map01100 H biosynthesis protein thiH COG1060 Cluster_162042 V1217975 HYDF S gtp-binding protein COG1160 Cluster_353719 V1217976 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_319902 V1217977 SP_1381 V abc transporter atp-binding protein COG1131 Cluster_200886 V1217978 S NA 0YEPS Cluster_79480 V1217979 PURF map00230,map00250,map01100,map01110 F glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_523148 V1217980 MT0828 S NA 11U2D Cluster_241156 V1217981 map00130,map00362,map01100,map01110,map01120 I thioesterase COG1607 Cluster_576409 V1217982 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_497106 V1217983 BL01774 map00053,map01100,map01120,map02060 G IIa component COG1762 Cluster_345743 V1217984 map00030,map01100,map01110,map01120,map01230 G Transaldolase COG0176 Cluster_405373 V1217985 V HsdM N-terminal domain COG0286 Cluster_167677 V1217987 YGFZ map00260,map00670,map00910,map01100 S Folate-binding protein YgfZ COG0354 Cluster_261671 V1217988 PABC map00280,map00290,map00770,map00790,map01100,map01110,map01210,map01230 E Aminotransferase COG0115 Cluster_361987 V1217989 I May play a role in the intracellular transport of hydrophobic ligands 11G4X Cluster_101138 V1217990 LEUC map00290,map00660,map01100,map01110,map01210,map01230 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) COG0065 Cluster_338116 V1217991 K HTH_ICLR COG1414 Cluster_247739 V1217992 BMUL_2943 G Major Facilitator Superfamily 0XNST Cluster_382325 V1217993 NNRE G Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity) COG0062 Cluster_224327 V1217994 DNAC L DNA replication protein COG1484 Cluster_382326 V1217995 OPUCD map02010 E Glycine betaine carnitine choline COG1174 Cluster_224328 V1217996 OPUCC map02010 M Glycine betaine COG1732 Cluster_33524 V1217997 UVRD map03420,map03430 L ATP-dependent DNA helicase pcra COG0210 Cluster_43132 V1217998 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_708447 V1217999 GATC map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0721 Cluster_257720 V1218001 S CAAX amino terminal protease family protein COG1266 Cluster_832236 V1218002 HSDM V type I restriction-modification system COG0286 Cluster_238605 V1218003 KDGT P The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) 0XNUJ Cluster_131893 V1218004 AMD E amidohydrolase COG1473 Cluster_456889 V1218005 S DNA-binding helix-turn-helix protein 11HJM Cluster_551892 V1218006 YPJC S YitT family COG1284 Cluster_699178 V1218007 HUP L DNA-binding protein COG0776 Cluster_228941 V1218008 PRSA O Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) COG0760 Cluster_22100 V1218009 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_193481 V1218010 NRDF map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_97881 V1218011 TET38 P MFS family major facilitator transporter, tetracycline cation symporter COG0477 Cluster_175333 V1218012 ACD map00071,map00280,map00281,map00362,map00410,map00640,map00650,map01100,map01110,map01120,map03320 I Acyl-CoA dehydrogenase, C-terminal domain COG1960 Cluster_540113 V1218013 ARGF map00330,map01100,map01110,map01230 E ornithine carbamoyltransferase COG0078 Cluster_449006 V1218014 CHLI map00860,map01100,map01110 H magnesium chelatase COG1240 Cluster_168527 V1218015 CHLI map00860,map01100,map01110 H magnesium chelatase COG1239 Cluster_89506 V1218016 MQO map00620 C malate dehydrogenase (quinone) COG0579 Cluster_200887 V1218017 I Alpha beta hydrolase fold COG2267 Cluster_751507 V1218018 S UPF0473 protein 0Z6ED Cluster_512449 V1218019 FUR P Ferric uptake COG0735 Cluster_68561 V1218020 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_632861 V1218021 S Protein of unknown function (DUF964) 102XZ Cluster_382327 V1218022 YRRM map00340,map00350,map00360,map00624,map00940,map00941,map00945,map01100,map01110,map01120 S O-methyltransferase COG4122 Cluster_148080 V1218023 YEGQ map05120 O Peptidase U32 COG0826 Cluster_193482 V1218024 E, G Membrane COG0697 Cluster_268386 V1218025 ASD map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) COG0136 Cluster_98435 V1218026 S Predicted membrane protein (DUF2157) 11HGJ Cluster_517819 V1218027 MUTB map00280,map00630,map00640,map00720,map01100,map01120 I Methylmalonyl-coA mutase COG2185 Cluster_49369 V1218028 MUTA map00280,map00630,map00640,map00720,map01100,map01120 I Methylmalonyl-coA mutase COG2185 Cluster_357084 V1218029 HFLC O SPFH domain, Band 7 family protein COG0330 Cluster_319903 V1218030 THYX map00240,map00340,map00350,map00624,map00670,map01120 F Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) COG1351 Cluster_454954 V1218031 S NA 0YF67 Cluster_460906 V1218032 MCSA S Uvrb UvrC protein COG3880 Cluster_223152 V1218033 MCSB map00330 E ATP guanido phosphotransferase COG3869 Cluster_23124 V1218034 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_60652 V1218035 V ABC superfamily ATP binding cassette transporter, ABC membrane protein COG1132 Cluster_35995 V1218036 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_104595 V1218037 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_276393 V1218039 M (sortase) family COG3764 Cluster_283107 V1218040 SRTC M (sortase) family COG3764 Cluster_271048 V1218041 SRTB M (sortase) family COG3764 Cluster_189882 V1218044 S Triacylglycerol lipase COG1075 Cluster_68218 V1218045 NNR G carbohydrate kinase, YjeF related protein COG0063 Cluster_74484 V1218046 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0802 Cluster_292649 V1218047 P ABC 3 transport family protein 128A2 Cluster_185560 V1218048 MNTA map02010 P periplasmic solute binding protein COG0803 Cluster_177783 V1218049 BMPA S basic membrane COG1744 Cluster_836123 V1218050 YFGQ P Cation-transporting atpase COG0474 Cluster_378826 V1218051 DEOC map00030 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) COG0274 Cluster_305168 V1218052 HISK map00340,map01100,map01110,map01230 E histidinol phosphate phosphatase hisj family COG1387 Cluster_238606 V1218053 GYAR map00260,map00630,map00680,map01100,map01120,map01230 C 2-hydroxyacid dehydrogenase COG1052 Cluster_131122 V1218054 WBLL S NA 0XWNY Cluster_176951 V1218055 TELA P Resistance protein COG3853 Cluster_94689 V1218056 S NA 0XWFB Cluster_310723 V1218059 COMEA L Competence protein COG1555 Cluster_58278 V1218060 COMEC S ComEC Rec2-like protein COG0658 Cluster_73855 V1218061 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_151215 V1218062 S SAM-dependent methyltransferase COG1092 Cluster_283108 V1218063 L nudix hydrolase COG0494 Cluster_40709 V1218064 GLGE map00500,map01100,map04973 G Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) COG0366 Cluster_196963 V1218065 MT3314 I diacylglycerol kinase, catalytic region COG1597 Cluster_122153 V1218066 MT3308 S secreted protein 0XRRW Cluster_233694 V1218067 PRMA J Methylates ribosomal protein L11 (By similarity) COG2264 Cluster_211610 V1218068 DGT map00230 F deoxyguanosinetriphosphate triphosphohydrolase-like protein COG0232 Cluster_738003 V1218069 RPSQ map03010 J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal COG0186 Cluster_134265 V1218070 S NA 0ZCNR Cluster_291291 V1218071 RLUD J pseudouridine synthase COG0564 Cluster_291292 V1218072 PPNK map00760,map01100 G Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) COG0061 Cluster_692088 V1218073 KDPC map02020 P One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) COG2156 Cluster_36548 V1218074 KDPB map02020 P One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) COG2216 Cluster_70236 V1218075 KDPA map02020 P One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) COG2060 Cluster_62371 V1218077 V ABC transporter COG1132 Cluster_582753 V1218082 TRPE map00400,map01100,map01110,map01230 E anthranilate synthase component i COG0147 Cluster_312250 V1218083 HISF map00340,map01100,map01110,map01230 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) COG0107 Cluster_287330 V1218084 IMPA map00521,map00562,map01100,map01110,map04070 G inositol mono-phosphatase COG0483 Cluster_333539 V1218085 HISA map00340,map00400,map01100,map01110,map01230 E Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase COG0106 Cluster_463026 V1218086 J ribosome-associated inhibitor protein Y COG1544 Cluster_36684 V1218087 S Transglycosylase SLT domain COG3953 Cluster_233695 V1218090 MT4035 S NA 0XR0D Cluster_255206 V1218091 HUNADC P transporter COG0471 Cluster_80970 V1218092 RPOD K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_589245 V1218093 S RteC protein 10SVC Cluster_114877 V1218094 V MatE COG0534 Cluster_279061 V1218095 K Transcriptional regulator, ARAC family COG2207 Cluster_523149 V1218096 S NA 11NIN Cluster_35569 V1218097 FEOB P Ferrous iron transport protein b COG0370 Cluster_751508 V1218098 FEOA P Ferrous iron transport protein A COG1918 Cluster_773618 V1218099 P domain protein 101JI Cluster_261672 V1218100 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_800884 V1218101 LKTB3 V ABC transporter, ATP-binding protein COG2274 Cluster_220809 V1218102 S Protein of unknown function (DUF2984) 0Z0TY Cluster_44286 V1218103 NRDF map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_744740 V1218106 PFLAC C Formate acetyltransferase COG1882 Cluster_545936 V1218108 S NA 0YDRM Cluster_683120 V1218109 S NA 0YPRS Cluster_33637 V1218110 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_61272 V1218111 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 Cluster_238607 V1218112 HMUT map02010 P Periplasmic binding protein COG4558 Cluster_189019 V1218113 HMUU map02010 P transport system permease protein COG0609 Cluster_289979 V1218114 HMUV map02010 P Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) COG4559 Cluster_358754 V1218115 HMUO map00860,map04978 P Heme oxygenase COG5398 Cluster_284483 V1218117 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120 G phosphohexose isomerase COG0166 Cluster_89972 V1218118 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_3423 V1218119 U, W Inherit from COG: domain protein COG5295 Cluster_403565 V1218120 THIM map00730,map01100 H 4-methyl-5-beta-hydroxyethylthiazole kinase COG2145 Cluster_442961 V1218121 THIW S thiw protein COG4732 Cluster_54027 V1218122 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_155292 V1218123 S NA 125RX Cluster_257721 V1218124 K cell envelope-related transcriptional attenuator COG1316 Cluster_280365 V1218125 S Membrane COG1434 Cluster_298177 V1218126 map02010 P cobalt transport COG0619 Cluster_38493 V1218127 S NA 121Q8 Cluster_224329 V1218128 S NA 126B8 Cluster_237292 V1218129 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_49370 V1218130 MUTL map03430 L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) COG0323 Cluster_95204 V1218131 M Cell wall anchor domain protein 11PS2 Cluster_205045 V1218132 DMPA E, Q peptidase s58 dmpa COG3191 Cluster_124094 V1218133 GLTT C -dicarboxylate symporter COG1301 Cluster_18860 V1218134 map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_465113 V1218135 YMDB S appr-1-p processing domain protein COG2110 Cluster_625314 V1218136 S NA 0XX7Y Cluster_241157 V1218137 RBSC-2 S abc transporter, permease COG1079 Cluster_182985 V1218138 RBSC-1 S ABC transporter (Permease) COG4603 Cluster_67523 V1218139 PPAC map00190 C Manganese-dependent inorganic pyrophosphatase COG1227 Cluster_246479 V1218141 WBBL M Glycosyl transferase, family 2 COG1216 Cluster_225505 V1218142 RFBD map00521,map00523,map01100,map01110 M Dtdp-4-dehydrorhamnose reductase COG1091 Cluster_219622 V1218143 LYTR1 K TRANSCRIPTIONal COG1316 Cluster_59589 V1218144 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_327590 V1218145 SCLAV_1530 S UPF0246 protein COG3022 Cluster_185561 V1218146 CYSG map00860,map01100,map01110 H Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) COG0007 Cluster_171148 V1218147 G abc transporter integral membrane protein COG1172 Cluster_373567 V1218150 SP_0899 S Membrane Associated 114SZ Cluster_197893 V1218151 MVAK2 map00900,map01100,map01110 I Phosphomevalonate kinase COG1577 Cluster_157815 V1218152 MVAS map00072,map00280,map00650,map00900,map01100,map01110 I Hydroxymethylglutaryl-CoA synthase COG3425 Cluster_171967 V1218154 GLGC map00500,map00520,map01100,map01110 G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) COG0448 Cluster_179500 V1218155 GLGD map00500,map00520,map01100,map01110 M glucose-1-phosphate adenylyltransferase, glgd subunit COG0448 Cluster_101698 V1218156 GLGA map00500,map01100,map01110,map04973 G Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) COG0297 Cluster_105189 V1218158 NORM V Mate efflux family protein COG0534 Cluster_163681 V1218162 S NA 0Z2CV Cluster_534406 V1218166 S Protein of unknown function (DUF1049) 12CJV Cluster_300827 V1218167 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_288683 V1218168 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_430958 V1218169 RPSB map03010 J 30S ribosomal protein S2 COG0052 Cluster_8005 V1218170 PYC map00020,map00620,map00720,map01100,map01120,map01230 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) COG1038 Cluster_177784 V1218171 S gtp-binding protein COG3596 Cluster_436939 V1218173 FOLE map00790,map01100 H GTP cyclohydrolase i COG0302 Cluster_489619 V1218174 S domain protein COG1418 Cluster_766218 V1218177 YVLC S phage shock protein C, PspC COG1983 Cluster_119125 V1218180 L transposase, IS605 OrfB COG0675 Cluster_644780 V1218181 L transposase COG1943 Cluster_450979 V1218183 COAD map00770,map01100 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) COG0669 Cluster_329086 V1218184 S Phage replisome organizer 0ZW0Q Cluster_250306 V1218185 SCLAV_3818 map00010,map00040,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00640,map00903,map01100,map01110,map01120 C Aldehyde dehydrogenase COG1012 Cluster_33244 V1218186 BETT P Transporter COG1292 Cluster_352056 V1218187 GLUB map02010,map02020 E, T Extracellular solute-binding protein family 3 COG0834 Cluster_358755 V1218188 GLUC map02010 E ABC transporter COG0765 Cluster_232425 V1218189 GLUD map02010 E amino acid AbC transporter COG0765 Cluster_465114 V1218190 C flavodoxin family COG0716 Cluster_157816 V1218193 YTFP S hi0933 family COG2081 Cluster_347319 V1218194 RLUB J Pseudouridine synthase COG1187 Cluster_18674 V1218197 S NA 10111 Cluster_365299 V1218198 STP T phosphatase COG0631 Cluster_109426 V1218199 MIAB J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) COG0621 Cluster_213816 V1218200 LACC map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G tagatose-6-phosphate kinase COG1105 Cluster_74814 V1218201 S fad dependent oxidoreductase COG2509 Cluster_316853 V1218202 TATD L Hydrolase, tatD family COG0084 Cluster_456891 V1218203 RNMV L Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) COG1658 Cluster_277702 V1218204 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_48959 V1218205 M Putative cell wall binding repeat 2 COG2247 Cluster_863863 V1218206 SCFA S RSAM-modified six-cysteine peptide 0XUIZ Cluster_57023 V1218207 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 Cluster_198888 V1218208 REP L Replication Protein COG5527 Cluster_74485 V1218209 S relaxase Mobilization nuclease 17A1X@proNOG Cluster_196964 V1218212 YCIC S cobalamin synthesis protein P47K COG0523 Cluster_88571 V1218213 CAT1 map00281,map00620,map00626,map01110,map01120 C Transferase COG0427 Cluster_91863 V1218214 SERA map00260,map00270,map00680,map01100,map01120,map01230 E d-3-phosphoglycerate dehydrogenase COG0111 Cluster_234892 V1218215 TRXB map00240,map00450 O thioredoxin reductase COG0492 Cluster_231266 V1218217 I Diacylglycerol kinase COG1597 Cluster_50159 V1218218 NDVA V ABC superfamily ATP binding cassette transporter COG1132 Cluster_438972 V1218219 MAK map00500,map01100 G Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) COG3281 Cluster_365300 V1218220 K Transcriptional regulator, TetR family 11IM0 Cluster_375282 V1218221 LOLD V abc transporter atp-binding protein COG1136 Cluster_176952 V1218222 APBE H ApbE family COG1477 Cluster_467194 V1218223 S NA 0YPTE Cluster_268387 V1218225 COBS map00860,map01100 H Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) COG0368 Cluster_36869 V1218226 YWMD S von Willebrand factor, type A COG2304 Cluster_83006 V1218227 GLTD map00250,map00910,map01100,map01110,map01120,map01230 E Glutamate synthase COG0493 Cluster_21001 V1218228 GLTB map00250,map00630,map00910,map01100,map01110,map01120,map01230 E Glutamate synthase COG0070 Cluster_705344 V1218229 PTSH G phosphocarrier protein (HPr COG1925 Cluster_396550 V1218230 PPIB O PPIases accelerate the folding of proteins COG0652 Cluster_253997 V1218231 map00190,map00680,map01100 C ATP synthase alpha/beta chain, C terminal domain COG1155 Cluster_563696 V1218232 GLOA map00620,map04011 E Lactoylglutathione lyase COG0346 Cluster_403566 V1218233 PTH J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) COG0193 Cluster_629038 V1218234 S Phospholipase, patatin family 0YEF4 Cluster_285921 V1218235 S Phospholipase, patatin family 0YEF4 Cluster_477936 V1218236 S NA 11XBE Cluster_57271 V1218237 MDLA V ABC transporter COG1132 Cluster_330483 V1218238 MUTE map02010 S ABC transporter, permease 11NSJ Cluster_373568 V1218239 SPAR T response regulator COG0745 Cluster_741428 V1218240 T His Kinase A (phospho-acceptor) domain COG2205 Cluster_515152 V1218241 F nudix hydrolase COG1051 Cluster_367004 V1218251 SCLAV_0739 map00620 S Beta-lactamase domain protein 10GCR Cluster_268388 V1218252 PPIB O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) COG0652 Cluster_36397 V1218253 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_446983 V1218254 YHCG S Conserved Protein COG4804 Cluster_167678 V1218255 THIH map00730,map01100 H biosynthesis protein thiH COG1060 Cluster_318424 V1218256 THIG map00730,map01100 H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) COG2022 Cluster_410677 V1218257 THIF map00730,map01100,map04122 H Thiamine biosynthesis protein ThiF COG0476 Cluster_224330 V1218259 MVAD map00900,map01100,map01110 I diphosphomevalonate decarboxylase COG3407 Cluster_201879 V1218260 MVK map00900,map01100,map01110,map04146 I mevalonate kinase COG1577 Cluster_119126 V1218261 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_617864 V1218262 ILVB map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E acetolactate synthase COG0028 Cluster_471482 V1218263 ILVN map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E Acetolactate synthase small subunit COG0440 Cluster_98436 V1218264 P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) COG0168 Cluster_83007 V1218265 S ABC transporter COG0488 Cluster_231267 V1218266 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G phosphohexokinase COG0205 Cluster_417944 V1218267 S (sortase) family 11V31 Cluster_273709 V1218268 S AP2 domain 123DH Cluster_281709 V1218270 ETFB map00910 C Electron transfer flavoprotein COG2086 Cluster_177785 V1218271 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_246480 V1218272 PRMA J Methylates ribosomal protein L11 (By similarity) COG2264 Cluster_338117 V1218273 RSME S Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) COG1385 Cluster_312251 V1218276 D replication-associated protein COG1192 Cluster_96290 V1218280 YLOV S dak2 domain fusion protein ylov COG1461 Cluster_232426 V1218281 THIL map00730,map01100 H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) COG0611 Cluster_387711 V1218285 S Carbohydrate binding domain 1227X Cluster_333540 V1218287 M Bacteriophage peptidoglycan hydrolase COG0791 Cluster_617865 V1218289 S Toxin-antitoxin system, antitoxin component, HicB family 11KI8 Cluster_206120 V1218293 S Protein of unknown function (DUF3644) 11F6J Cluster_172875 V1218294 M group 1 glycosyl transferase COG0438 Cluster_242528 V1218295 DUSB J Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_306557 V1218296 COAX map00770,map01100 K Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) COG1521 Cluster_434888 V1218297 MT3354 S NA 11P0K Cluster_110742 V1218298 MANB map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G phosphomannomutase COG1109 Cluster_554753 V1218299 MT3357 S Possibl zinc metallo-peptidase 11VPR Cluster_285922 V1218301 GLPF G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) COG0580 Cluster_199884 V1218302 S filamentation induced by cAMP protein Fic COG3177 Cluster_135064 V1218303 T Histidine kinase COG0642 Cluster_357085 V1218304 T response regulator COG0745 Cluster_148081 V1218305 SCLAV_0509 S Cytochrome c oxidase caa3-type, assembly factor ctag-related protein COG3336 Cluster_68219 V1218307 YJJK S ABC transporter, ATP-binding protein COG0488 Cluster_380555 V1218308 TMK map00240,map01100 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) COG0125 Cluster_67889 V1218309 MTRB map02020 T Histidine kinase 0XNMH Cluster_554754 V1218311 S Toxin-antitoxin system, toxin component 0XRRU Cluster_242529 V1218312 MUTY map03410 L a g-specific adenine glycosylase COG1194 Cluster_414360 V1218313 CYNT map00910 P carbonic anhydrase COG0288 Cluster_116995 V1218314 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_322950 V1218315 CG1711 C Aldo keto reductase COG0667 Cluster_190745 V1218316 LPPL S prolipoprotein LppL 0Z2Q4 Cluster_182986 V1218317 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) COG0167 Cluster_112037 V1218318 ISOVA_0221 V HNH endonuclease 11RVB Cluster_179501 V1218319 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_352057 V1218320 CBIQ map02010 P Cobalt abc transporter COG0619 Cluster_303660 V1218321 CBIM map02010 P Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) COG0310 Cluster_242530 V1218322 CYSK map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_566890 V1218323 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_554755 V1218324 S NA 0ZJ2P Cluster_458858 V1218326 S Nitroreductase 1234Z Cluster_221972 V1218327 DUSB J Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_20847 V1218328 L dEAD DEAH box helicase COG1204 Cluster_512450 V1218330 S Gcn5-related n-acetyltransferase 17QRN@proNOG Cluster_392955 V1218332 LEXA K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) COG1974 Cluster_178624 V1218336 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_288684 V1218338 PANB map00770,map01100,map01110 H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) COG0413 Cluster_61273 V1218339 SCLAV_1772 S chad domain containing protein 0YY54 Cluster_773619 V1218340 SCLAV_1493 S NA 0XUCQ Cluster_452928 V1218342 SECF map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) COG0341 Cluster_47111 V1218343 SECD map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) COG0342 Cluster_330484 V1218344 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_303661 V1218346 OCAR_4090 map00240,map00380,map00410,map00460,map00627,map00643,map00770,map00910,map00983,map01100,map01120 S nitrilase cyanide hydratase and apolipoprotein n-acyltransferase COG0388 Cluster_384101 V1218347 SDPI S Membrane COG5658 Cluster_809129 V1218348 YVBA K Transcriptional regulator, arsr family COG0640 Cluster_326026 V1218349 K transcriptional regulator, IclR family COG1414 Cluster_162043 V1218350 PGN_0971 L Transposase, is4 family COG3039 Cluster_37645 V1218352 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_307864 V1218353 S NA 1119B Cluster_51922 V1218354 S NA 1217B Cluster_512451 V1218356 S NA 0Y5YG Cluster_150448 V1218358 S NA 0XW3Z Cluster_50762 V1218359 ASA S Ceramidase 0XQWE Cluster_336573 V1218361 FABG map00061,map00780,map01040,map01100 I reductase 0XNW1 Cluster_39476 V1218362 GLNN map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG3968 Cluster_714956 V1218363 RPSK map03010 J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) COG0100 Cluster_206121 V1218364 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_540114 V1218365 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_69937 V1218366 M Putative cell wall binding repeat 2 COG2247 Cluster_43133 V1218368 YYBT T domain protein COG3887 Cluster_144968 V1218370 GLYA map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01230 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) COG0112 Cluster_156949 V1218371 SUCB map00010,map00020,map00280,map00310,map00620,map01100,map01110,map01120 C 2-oxoglutarate dehydrogenase E2 component, dihydrolipoamide succinyltransferase COG0508 Cluster_83393 V1218372 PEPA map00480,map01100 E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) COG0260 Cluster_277703 V1218373 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E brancheD-chain amino acid aminotransferase COG0115 Cluster_50359 V1218374 GLGB map00500,map01100,map01110 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) COG0296 Cluster_212694 V1218375 IOLG2 map00521,map00562,map01100,map01110,map01120 Q Myo-inositol 2-dehydrogenase COG0673 Cluster_548992 V1218376 NUSB K Involved in the transcription termination process (By similarity) COG0781 Cluster_172876 V1218377 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_330485 V1218378 GUAB3 map00230,map00983,map01100,map01110 F Dehydrogenase COG0516 Cluster_80581 V1218379 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_540115 V1218380 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_225506 V1218381 map00010,map01110,map01120 G aldose 1-epimerase COG2017 Cluster_53277 V1218382 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_309281 V1218383 MRP D ATP-binding protein COG0489 Cluster_247740 V1218384 S phage protein 0XQDU Cluster_492118 V1218385 S Alanine rich transmembrane protein 11W3D Cluster_310724 V1218386 MT2770 S Protein of unknown function (DUF3710) 11Q1S Cluster_145715 V1218387 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_55496 V1218388 PULA G Glycogen debranching enzyme COG1523 Cluster_51324 V1218389 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_264347 V1218390 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_330486 V1218396 FETB map02010 P Periplasmic binding protein COG4607 Cluster_199885 V1218397 FATC map02010 P permease protein COG4605 Cluster_321385 V1218398 FEUA map02010 P abc transporter atp-binding protein COG4604 Cluster_617866 V1218399 RNHA map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0328 Cluster_319904 V1218402 S Pfam:DUF124 COG2013 Cluster_9733 V1218404 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_793003 V1218405 MODE H TOBE domain protein COG3585 Cluster_12712 V1218406 GLNE O, T Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) COG1391 Cluster_296776 V1218410 map00561,map01100 S Secretory lipase 0YTM1 Cluster_440947 V1218411 ECFT map02010 P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) COG0619 Cluster_298178 V1218412 ZURM map02010 P ABC, transporter COG1108 Cluster_370329 V1218413 ADCC map02010 P ABC transporter COG1121 Cluster_191664 V1218414 ZNUA map02010 P periplasmic solute binding protein COG0803 Cluster_428988 V1218415 S NA 0XU7T Cluster_617868 V1218416 L UPF0102 protein COG0792 Cluster_292650 V1218417 YQFL S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) COG1806 Cluster_18675 V1218418 PPDK map00620,map00680,map00710,map00720,map01100,map01120 G Pyruvate phosphate dikinase COG0574 Cluster_477937 V1218419 RUVC map03440 L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) COG0817 Cluster_332049 V1218420 FABG map00061,map00780,map01040,map01100 S reductase 0XNW1 Cluster_341003 V1218421 T Two component transcriptional regulator, winged helix family COG0745 Cluster_117713 V1218422 map02020 T Histidine kinase COG0642 Cluster_781086 V1218424 RPOZ map00230,map00240,map01100,map03020 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) COG1758 Cluster_164489 V1218425 COABC map00770,map01100 H Phosphopantothenoylcysteine decarboxylase COG0452 Cluster_458859 V1218426 AHCY map00270,map01100 H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) COG0499 Cluster_169459 V1218427 MANA map00051,map00520,map01100,map01110 G mannose-6-phosphate isomerase COG1482 Cluster_61811 V1218429 map02010 V abc transporter COG1132 Cluster_438973 V1218430 map00790,map01100 H Pterin binding enzyme COG0294 Cluster_847968 V1218431 S Protein of unknown function (DUF3117) 121WY Cluster_262963 V1218432 RRMA Q Methyltransferase COG0500 Cluster_360422 V1218433 BUDA map00650,map00660 Q Alpha-acetolactate decarboxylase COG3527 Cluster_295433 V1218434 G Inherit from NOG: Cellulase (glycosyl hydrolase family 5) 0ZVSV Cluster_19205 V1218435 L Inherit from COG: helicase 0XPYJ Cluster_446984 V1218436 FTHC map00670,map01100 H 5-formyltetrahydrofolate cyclo-ligase COG0212 Cluster_218460 V1218437 map00330,map01110,map01230 E Ornithine cyclodeaminase 10EHU Cluster_227759 V1218438 S oxygenase 0YDQ0 Cluster_84283 V1218439 STSA S Extracellular solute-binding protein, family 5 0XQUV Cluster_220810 V1218440 S cAMP factor 0YS1B Cluster_63746 V1218441 S CAMP factor (Cfa) 0Z1YX Cluster_246481 V1218442 G Ig domain protein, group 2 domain protein COG5492 Cluster_47288 V1218443 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_205046 V1218444 S NA 0YXS4 Cluster_273710 V1218445 map02010 V ABC transporter 0XPIZ Cluster_53278 V1218446 map02010 V ABC transporter 0XPIZ Cluster_164490 V1218447 BL01323 M Cell wall binding repeat 2-containing protein 0ZKZU Cluster_245157 V1218448 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_81342 V1218449 CAS3 L CRISPR-Associated Helicase Cas3 COG1203 Cluster_396552 V1218450 BION map02010 P Cobalt transport protein COG0619 Cluster_288685 V1218451 K, T Phage shock protein A COG1842 Cluster_209400 V1218452 CYDB map00190,map01100,map02020 C cytochrome d ubiquinol oxidase, subunit ii COG1294 Cluster_410678 V1218453 CYDD map02010 V ABC, transporter COG4988 Cluster_674146 V1218455 TRXA O Thioredoxin COG0526 Cluster_648834 V1218456 S NA 0ZJ2P Cluster_38314 V1218457 CTPC map00190 P heavy metal translocating P-type ATPase COG2217 Cluster_370330 V1218458 G isomerase COG0698 Cluster_399998 V1218459 LEPB map03060 U Signal peptidase i COG0681 Cluster_260345 V1218460 RNHC map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG1039 Cluster_678595 V1218461 S Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) 0XUW5 Cluster_440948 V1218462 CVPA S cvpA family COG1286 Cluster_560741 V1218463 RPSK map03010 J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) COG0100 Cluster_300828 V1218464 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_569971 V1218466 ADK map00230,map00240,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_17010 V1218467 S NA 0YAQZ Cluster_291293 V1218468 GDHA map00250,map00330,map00910,map01100 E Glutamate dehydrogenase COG0334 Cluster_319905 V1218469 S membrane 11VWI Cluster_223153 V1218470 SSCG_01435 E ABC transporter COG0765 Cluster_408819 V1218471 K Transcriptional regulator 11NA6 Cluster_306558 V1218472 SCLAV_0396 V ABC transporter COG1132 Cluster_125410 V1218473 RIMO J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) COG0621 Cluster_142768 V1218474 HFLX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COG2262 Cluster_38991 V1218475 map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_299461 V1218479 S NA 11H5V Cluster_29895 V1218480 PEPN map00480,map01100 E aminopeptidase N COG0308 Cluster_257722 V1218482 M (sortase) family COG3764 Cluster_57024 V1218483 M Cell wall anchor domain protein 129AF Cluster_384102 V1218485 CLOSA_0730 V Hnh endonuclease COG1479 Cluster_155293 V1218487 ECORIM L Modification methylase EcoRI 17X1E@proNOG Cluster_5789 V1218490 S NA 0YCCW Cluster_520373 V1218494 COMEB map00240,map01100 F deaminase COG2131 Cluster_377052 V1218495 CG2401 M Secreted protein COG0791 Cluster_70539 V1218502 S NA 0ZWV4 Cluster_487260 V1218503 S BioX protein 11WNI Cluster_353720 V1218504 BIOW map00780,map01100 H Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) COG1424 Cluster_223154 V1218505 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii subunits gamma and tau COG2812 Cluster_115560 V1218507 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_238608 V1218508 CTAB map00190,map00860,map01100,map01110 O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) COG0109 Cluster_355394 V1218509 CTAA map00190,map00860,map01100,map01110,map02020 O cytochrome oxidase assembly COG1612 Cluster_534407 V1218510 BL01497 Q methyltransferase COG0500 Cluster_80582 V1218511 MMDA map00280,map00630,map00640,map00720,map01100,map01120 I Methylmalonyl-CoA carboxyltransferase 12S subunit COG4799 Cluster_102797 V1218512 OADA map00020,map00330,map00620,map00720,map01100,map01120,map01230 C Oxaloacetate decarboxylase COG5016 Cluster_683121 V1218513 SCLAV_4880 map00500,map01100,map01110 G Glycogen debranching enzyme COG1523 Cluster_31740 V1218514 S NA 11U17 Cluster_335044 V1218515 GLNQ map02010 E abc transporter atp-binding protein COG1126 Cluster_162044 V1218516 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_39799 V1218518 S NA 0YCC9 Cluster_207230 V1218520 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_335045 V1218521 S NA 122AV Cluster_551894 V1218522 S Toxin-antitoxin system, antitoxin component, HicB family 12518 Cluster_176953 V1218523 EMBC M Arabinosyltransferase 0XSQE Cluster_41218 V1218524 AFTA M Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases 0Z57H Cluster_206122 V1218525 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_324525 V1218526 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_83008 V1218527 PPC map00620,map00680,map00710,map00720,map01100,map01120 C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) COG2352 Cluster_28153 V1218528 CAFA map03018 J ribonuclease COG1530 Cluster_674147 V1218529 RPLU map03010 J This protein binds to 23S rRNA in the presence of protein L20 (By similarity) COG0261 Cluster_734676 V1218530 RPMA map03010 J 50S ribosomal protein l27 COG0211 Cluster_119890 V1218532 S NA 0ZTYV Cluster_139780 V1218535 HTRA map03010 M peptidase S1 and S6, chymotrypsin Hap COG0265 Cluster_285923 V1218536 YOCS S Bile acid COG0385 Cluster_35430 V1218537 DEAD map03018 L RNA helicase COG0513 Cluster_79790 V1218538 S NA 0Y3S5 Cluster_124749 V1218539 P NMT1/THI5 like COG0715 Cluster_523150 V1218540 ZNTR K Transcriptional regulator COG0789 Cluster_471483 V1218541 S NA 1296H Cluster_187318 V1218542 PERMEASE S permease COG0701 Cluster_223155 V1218543 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit epsilon COG0847 Cluster_153652 V1218544 MURE map00300,map00550 M mur ligase COG0769 Cluster_319906 V1218545 COBQ S Glutamine amidotransferase COG3442 Cluster_419714 V1218547 map02010 P ATP-binding protein COG1120 Cluster_192596 V1218548 map02010 P Periplasmic binding protein COG0614 Cluster_391143 V1218549 S Membrane COG3949 Cluster_61274 V1218550 PTSG map00010,map00500,map00520,map02060 G PTS system COG2190 Cluster_133479 V1218551 BGLG K antiterminator COG3711 Cluster_531623 V1218552 PTSI map02060 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) COG1080 Cluster_361988 V1218553 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_265675 V1218554 YQFU S YitT family COG1284 Cluster_896283 V1218555 map00630,map01100 G Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) COG3622 Cluster_104596 V1218556 S AIPR protein 0ZFWF Cluster_405374 V1218557 K Pfam:DUF2174 COG4832 Cluster_176128 V1218558 S regulatory protein COG3641 Cluster_361989 V1218559 FHUC map02010 P ABC transporter COG1121 Cluster_268389 V1218560 map02010 P ABC transporter COG1108 Cluster_347320 V1218561 S Membrane COG3503 Cluster_275063 V1218562 YGCG S of methanol dehydrogenase type COG1512 Cluster_119891 V1218563 M Cell wall anchor domain protein 129AF Cluster_276394 V1218565 SRTB M (sortase) family COG3764 Cluster_216128 V1218566 GPSA map00564 C NADPH-dependent glycerol-3-phosphate dehydrogenase COG0240 Cluster_129612 V1218567 T Calcineurin-like phosphoesterase COG4639 Cluster_212695 V1218568 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_201880 V1218569 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_168528 V1218570 TGT J Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COG0343 Cluster_33389 V1218573 SCLAV_3021 S (twin-arginine translocation) pathway signal COG3211 Cluster_661272 V1218574 S NA 11W2C Cluster_48072 V1218576 FTSI map00550,map01100 M penicillin-binding protein COG0768 Cluster_517821 V1218577 S NA 11NZP Cluster_358756 V1218578 SSCG_03030 map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_161209 V1218579 V permease COG0577 Cluster_49580 V1218580 map00350,map00362,map00627,map00642,map00903,map01120 I acyltransferase 3 COG1835 Cluster_363556 V1218581 YEIH S Membrane COG2855 Cluster_218461 V1218582 S copper amine 0XP8R Cluster_134266 V1218583 METY map00270,map00450,map00920,map01100,map01110,map01230 E Cys/Met metabolism PLP-dependent enzyme COG2873 Cluster_189020 V1218585 LACI K laci family transcriptional regulator COG1609 Cluster_528835 V1218586 PSAA map02010 P ABC transporter COG0803 Cluster_582754 V1218587 S NA 12866 Cluster_512452 V1218589 RPIB map00030,map00710,map01100,map01110,map01120,map01230 G isomerase COG0698 Cluster_368619 V1218590 RND J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) COG0349 Cluster_436940 V1218591 SCLAV_4848 S Protein of unknown function (DUF3000) 11PF6 Cluster_288686 V1218592 HEMG map00860,map01100,map01110 H protoporphyrinogen oxidase COG1232 Cluster_227760 V1218594 DNAG map03030 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 Cluster_389411 V1218595 S Metallo-beta-lactamase superfamily COG0491 Cluster_163683 V1218596 ADHE2 map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map05204 C Dehydrogenase COG1062 Cluster_438974 V1218597 SP_1232 S Membrane COG4684 Cluster_256437 V1218598 SDAAA map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase COG1760 Cluster_86820 V1218599 VANW V VanW family COG2720 Cluster_174519 V1218601 S NA 0ZVJP Cluster_338119 V1218602 S NA 0Z20Q Cluster_531624 V1218603 S Phage major capsid protein COG4653 Cluster_285924 V1218604 CLPP map04112 O ATP-dependent Clp protease, proteolytic subunit COG0740 Cluster_160379 V1218605 O phage portal protein HK97 family COG4695 Cluster_252742 V1218606 OCAR_6158 L Terminase, large subunit COG4626 Cluster_101699 V1218607 S Copper amine oxidase domain-containing protein 0XT7E Cluster_299462 V1218608 S NA 0ZUR0 Cluster_108794 V1218610 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_287331 V1218611 S NA 11GJK Cluster_430959 V1218613 DNAQ2 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit epsilon COG0847 Cluster_175334 V1218614 ASPB E Aminotransferase COG0436 Cluster_164491 V1218615 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_296777 V1218616 MT0808 S Inherit from COG: deacetylase COG3233 Cluster_414361 V1218620 S RNA ligase 0Y4VX Cluster_399999 V1218622 RSMG M Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) COG0357 Cluster_502301 V1218623 TRMK S SAM-dependent methyltransferase COG2384 Cluster_57025 V1218624 DNAG map03030 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 Cluster_170322 V1218628 SURB S G5 domain protein 0ZVV3 Cluster_237293 V1218629 PSTS2 map02010,map02020,map05152 P Phosphate-binding protein COG0226 Cluster_122154 V1218630 map00051,map00363,map00520,map00591,map00625,map00650,map01100,map01120 M Dehydrogenase COG0677 Cluster_421510 V1218631 WBPD map00520 S Transferase hexapeptide repeat containing protein COG0110 Cluster_158690 V1218632 DEGT E DegT DnrJ EryC1 StrS aminotransferase COG0399 Cluster_387712 V1218634 CASE L crispr-associated protein 0XPHC Cluster_358757 V1218635 CAS5E L crispr-associated protein 11JEJ Cluster_176129 V1218636 CSE4 L Crispr-associated protein, cse4 family 0Y6PV Cluster_243880 V1218637 CASA L crispr-associated protein 0XPA1 Cluster_442962 V1218638 CTAE map00190,map00910,map01100 C oxidase (Subunit III) COG1845 Cluster_192597 V1218639 TRPD map00400,map01100,map01110,map01230 E anthranilate phosphoribosyltransferase COG0547 Cluster_7622 V1218640 S NA 0ZHVH Cluster_436941 V1218641 PEPS E aminopeptidase COG2309 Cluster_76096 V1218643 MEPA M peptidase COG0739 Cluster_419716 V1218644 S Allergen V5 TPX-1 0XUG5 Cluster_281710 V1218645 K transcriptional regulator, merr family COG0789 Cluster_232427 V1218646 L integrase family 0ZJHZ Cluster_99486 V1218647 L helicase COG4646 Cluster_54295 V1218650 S Oligopeptide transporter, Opt family COG1297 Cluster_625317 V1218651 S Coenzyme PQQ synthesis protein D (PqqD) 11PNC Cluster_777347 V1218652 C Anaerobic dehydrogenase COG0243 Cluster_683122 V1218653 E Branched-chain amino acid 0Y67M Cluster_347321 V1218654 AZLC E azlc family COG1296 Cluster_7979 V1218656 FAS map00061,map01100 I fatty acid synthase COG4982 Cluster_58279 V1218657 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_438975 V1218659 INFC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) COG0290 Cluster_813113 V1218660 RPMI map03010 J 50S ribosomal protein L35 COG0291 Cluster_287332 V1218661 TSNR J rrna methyltransferase COG0566 Cluster_294025 V1218662 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_141990 V1218663 BMUL_2277 L DNA Methylase COG1475 Cluster_824680 V1218664 S NA 0YY6Z Cluster_809130 V1218665 S NA 0XZ3Z Cluster_260346 V1218666 YHBJ S Displays ATPase and GTPase activities (By similarity) COG1660 Cluster_236088 V1218667 YBHK S UPF0052 protein COG0391 Cluster_502302 V1218668 T Two-component system sensor kinase COG4564 Cluster_122155 V1218669 G Major Facilitator Superfamily COG2807 Cluster_371949 V1218671 MT3543 S NA 11ISP Cluster_353721 V1218672 ISOVA_0221 V HNH endonuclease 11RVB Cluster_264349 V1218673 YTQA S Radical SAM Protein COG1242 Cluster_363557 V1218674 KTRA P domain protein COG0569 Cluster_335046 V1218675 SPOU J rrna methyltransferase COG0566 Cluster_207231 V1218676 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_245158 V1218677 PRKC T serine threonine protein kinase COG0515 Cluster_408820 V1218678 SUN J ribosomal RNA small subunit methyltransferase COG0144 Cluster_629040 V1218680 MAZF T Toxic component of a toxin-antitoxin (TA) module (By similarity) COG2337 Cluster_162045 V1218681 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_348938 V1218683 RPRY map02020 T response regulator COG0745 Cluster_126801 V1218684 CLCAR_1091 T Histidine kinase COG0642 Cluster_724877 V1218685 RHLE map03018 L atp-dependent rna helicase COG0513 Cluster_371950 V1218686 MURG map00550,map01100,map04112 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) COG0707 Cluster_89973 V1218687 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_174520 V1218688 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_288688 V1218689 PTS-EIID map00051,map00520,map01100,map02060 G PTS System COG3716 Cluster_259043 V1218690 PTS-EIIC map00051,map00520,map01100,map02060 G PTS System COG3715 Cluster_81750 V1218691 S integral membrane protein COG0628 Cluster_683123 V1218692 YQGV S Domain of unknown function DUF77 COG0011 Cluster_183803 V1218693 M Cell wall binding repeat 2-containing protein COG2247 Cluster_432969 V1218694 S Protein of unknown function (DUF523) COG5418 Cluster_271050 V1218695 S Inherit from NOG: Leucine rich repeat protein, bspa family protein 0Y4NF Cluster_463027 V1218696 S hemerythrin hhe cation binding domain protein COG3945 Cluster_499769 V1218697 SCLAV_3863 S Membrane 0XVS8 Cluster_276395 V1218698 MCA S mycothiol conjugate amidase mca COG2120 Cluster_189021 V1218699 AROF map00400,map01100,map01110,map01230 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) COG0722 Cluster_414362 V1218700 NTPE map00190,map00680,map01100 C subunit e 0Y7S3 Cluster_489620 V1218701 NTPK map00190,map00680,map01100 C V-type sodium ATPase, K subunit COG0636 Cluster_79481 V1218702 S Pfam:DUF88 COG1432 Cluster_135065 V1218703 P Major facilitator superfamily MFS_1 11HZQ Cluster_554756 V1218704 ISCR K Transcriptional regulator, BadM Rrf2 family COG1959 Cluster_104000 V1218705 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_589247 V1218706 S Protein of unknown function (DUF1294) 0ZYFY Cluster_167679 V1218707 VRAB map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map02020 I acetyl-CoA COG0183 Cluster_417945 V1218708 M Cell wall anchor domain protein 0YMXG Cluster_322952 V1218709 S Sortase family 11T4H Cluster_318425 V1218710 S Lpxtg-motif cell wall anchor domain protein 0XQBH Cluster_93746 V1218711 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_695901 V1218713 CAS2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) COG1343 Cluster_540116 V1218715 SCLAV_2692 E ABC transporter COG1123 Cluster_319907 V1218716 DPRE2 I, Q short-chain dehydrogenase reductase COG1028 Cluster_221973 V1218717 DPRE1 C FAD linked oxidase domain protein COG0277 Cluster_134267 V1218718 PHON map00627,map00740,map01120,map02020 I Phosphoesterase, PA-phosphatase related COG0671 Cluster_117714 V1218720 F permease COG2233 Cluster_206123 V1218721 C pyridine nucleotide-disulfide oxidoreductase family protein COG1252 Cluster_576411 V1218722 BMPA S basic membrane COG1744 Cluster_145716 V1218723 APGM map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG3635 Cluster_96808 V1218724 P transporter COG0471 Cluster_805092 V1218730 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_20151 V1218731 ADDA L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation COG1074 Cluster_58280 V1218732 MDLA V ABC transporter, ATP-binding protein COG1132 Cluster_421511 V1218733 XYLG S ABC transporter COG3845 Cluster_177786 V1218734 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_182987 V1218736 YIUA map02010 P Periplasmic binding protein COG0614 Cluster_114878 V1218737 NORM V Mate efflux family protein COG0534 Cluster_177787 V1218738 S X-X-X-Leu-X-X-Gly heptad repeats COG1511 Cluster_62372 V1218739 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_74815 V1218741 S NA 0Y12I Cluster_341004 V1218742 CAS6 L CRISPR-associated protein cas6 11MM9 Cluster_305169 V1218743 S Phospholipase, patatin family 0YEF4 Cluster_238609 V1218744 BL02952 S Membrane COG1434 Cluster_724878 V1218746 S prevent-host-death family 124KH Cluster_71234 V1218747 ABGT H Transporter COG2978 Cluster_170323 V1218748 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_414363 V1218749 RECR map03440 L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) COG0353 Cluster_502303 V1218750 S Phage-Associated Protein 120JX Cluster_114879 V1218751 K, L domain protein COG0553 Cluster_711579 V1218752 S VRR-NUC domain protein 122HE Cluster_20614 V1218753 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_183804 V1218754 D ATPase MipZ 0ZR7H Cluster_407061 V1218755 COMF S Competence protein COG1040 Cluster_105807 V1218756 XASA E amino acid COG0531 Cluster_347323 V1218757 XTHA map03410 L Exodeoxyribonuclease III COG0708 Cluster_430960 V1218758 K MarR family Transcriptional regulator 12CGG Cluster_648835 V1218759 S NA 11ZSB Cluster_471485 V1218760 MUTT3 L nudix hydrolase COG0494 Cluster_695902 V1218761 MT0425 S secreted protein 10SG5 Cluster_302218 V1218762 BMUL_5125 S UPF0317 protein COG4336 Cluster_291294 V1218764 S NA 0XQ6D Cluster_196965 V1218765 MT3095 S Methionine synthase vitamin-b12 independent 0XYJG Cluster_171968 V1218766 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_269737 V1218768 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_71514 V1218769 S NA 0YK1E Cluster_233696 V1218770 YYBS S Membrane COG4241 Cluster_342526 V1218771 K, L Inherit from COG: helicase COG0553 Cluster_421513 V1218772 YGFC K Transcriptional regulator 120E9 Cluster_196148 V1218773 S NA 0XS0Q Cluster_569972 V1218776 RPSP map03010 J 30s ribosomal protein S16 COG0228 Cluster_449007 V1218777 S Rhodanese domain protein 11KPM Cluster_179502 V1218778 OCAR_5156 E transglutaminase domain protein COG1305 Cluster_473596 V1218779 S NA 11FFJ Cluster_69258 V1218780 M NA 0YDBK Cluster_123461 V1218781 TRPB map00260,map00400,map01100,map01110,map01230 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) COG0133 Cluster_205047 V1218782 TRKH P Potassium uptake protein COG0168 Cluster_295434 V1218786 POTC map02010 P putrescine abc transporter COG1177 Cluster_392956 V1218787 S NA 11H00 Cluster_239879 V1218788 S esterase 1294K Cluster_124095 V1218789 HOM E saf domain-containing protein COG4091 Cluster_9877 V1218790 FAS map00061,map00350,map00362,map00627,map00642,map00903,map01100,map01120 I synthase COG4982 Cluster_277704 V1218791 S Secreted protein COG1376 Cluster_48073 V1218792 PKNG map05152 T Serine Threonine protein kinase COG0515 Cluster_121390 V1218793 ALL2459 S ATP GTP Binding Protein 0XQ3U Cluster_162886 V1218794 YDJZ S SNARE associated Golgi protein-related protein COG0398 Cluster_130339 V1218795 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_520374 V1218796 SAGG map02010 V ABC transporter, ATP-binding protein COG1131 Cluster_621530 V1218802 CKL_1885 S Protein of unknown function (DUF1064) 1251H Cluster_412492 V1218805 TNPR L resolvase COG1961 Cluster_26149 V1218808 T serine threonine protein kinase PknL (EC 2.7.11.1) COG2815 Cluster_589248 V1218809 MT2231 K transcriptional regulatory protein 11UQP Cluster_24067 V1218810 TRSE U traE protein COG3451 Cluster_333541 V1218811 ISTB L IstB domain-containing protein ATP-binding protein COG1484 Cluster_90912 V1218812 CVAR_1349 L Transposase COG4584 Cluster_554759 V1218813 TNPB L integrase catalytic COG2801 Cluster_288689 V1218814 NORM V Mate efflux family protein COG0534 Cluster_194419 V1218815 TSB map00260,map00270,map01100,map01230 E Cysteine synthase COG0031 Cluster_137476 V1218816 SSCG_02586 map00300,map01100,map01110,map01120,map01230 E decarboxylase COG0019 Cluster_189022 V1218818 S 5-bromo-4-chloroindolyl phosphate hydrolysis protein 111JX Cluster_177788 V1218819 TELA P Resistance protein COG3853 Cluster_45763 V1218821 MUTL map03430 L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) COG0323 Cluster_227761 V1218822 YBHK S UPF0052 protein COG0391 Cluster_259044 V1218823 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_358758 V1218824 YEBC K transcriptional regulatory protein COG0217 Cluster_557677 V1218825 MRNC S Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) COG1939 Cluster_310725 V1218826 map00230 S phosphorylase 11F11 Cluster_319908 V1218827 SOJ D Chromosome Partitioning Protein COG1192 Cluster_504702 V1218828 S ASCH domain 0Y0UK Cluster_307865 V1218829 S domain protein 0XNZW Cluster_148822 V1218830 S hi0933 family COG2081 Cluster_657041 V1218831 CUTA S divalent ion tolerance protein COG3323 Cluster_188178 V1218833 MT1293 map00350,map00362,map00627,map00642,map00903,map01120 I Acyl-transferase COG1835 Cluster_307866 V1218834 L TatD-related deoxyribonuclease COG0084 Cluster_87688 V1218835 S peptidase, S41 11FNN Cluster_313741 V1218837 S peptidase, S41 11FNN Cluster_551895 V1218838 M rhs family COG3209 Cluster_517823 V1218839 S Yqey-like protein COG1610 Cluster_107051 V1218840 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_216129 V1218841 M RND family efflux transporter COG0845 Cluster_347324 V1218842 RSUA J Pseudouridine synthase COG1187 Cluster_123462 V1218843 YWDH map00010,map00040,map00053,map00071,map00280,map00281,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00626,map00640,map00903,map01100,map01110,map01120 C Aldehyde dehydrogenase COG1012 Cluster_408821 V1218844 CPSD M Capsular exopolysaccharide family COG0489 Cluster_384103 V1218845 S Secreted protein 0XS2C Cluster_85536 V1218846 PUTP E Sodium proline symporter COG0591 Cluster_159541 V1218847 map02010 V ABC transporter 0XPIZ Cluster_554760 V1218848 MURG map00550,map01100,map04112 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) COG0707 Cluster_66857 V1218849 FTSW map04112 D Cell division protein, FtsW COG0772 Cluster_250307 V1218850 MURD map00471,map00550,map01100 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COG0771 Cluster_148083 V1218851 CAP5O map00051,map00363,map00520,map00591,map00625,map00650,map01100,map01120 M Dehydrogenase COG0677 Cluster_367005 V1218853 SPOU map00340,map00350,map00624,map01120 J tRNA rRNA methyltransferase COG0566 Cluster_280367 V1218854 S YhhN-like protein 0YYMV Cluster_785211 V1218855 YAAA S s4 domain protein COG2501 Cluster_159542 V1218856 DLPA map00020,map00290,map00480,map00720,map01100,map01110,map01120,map01210,map01230,map04146 E Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) COG0473 Cluster_446985 V1218857 S NA 11QTP Cluster_401787 V1218858 S Triacylglycerol lipase COG1075 Cluster_303662 V1218859 S Inherit from COG: Pfam:DUF567 COG4894 Cluster_436942 V1218860 S intracellular protease Pfpi family COG0693 Cluster_718199 V1218861 S phage protein 1262M Cluster_329087 V1218862 FABG map00061,map00780,map01040,map01100 S 3-oxoacyl- acyl-carrier-protein reductase 0XNW1 Cluster_143466 V1218863 FABF map00061,map00780,map01100 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) COG0304 Cluster_603175 V1218864 MMUM map00270,map01100,map01110 E Homocysteine COG2040 Cluster_81343 V1218865 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_56501 V1218867 PEPF map04614,map05143 E Oligoendopeptidase f COG1164 Cluster_203969 V1218869 FECD map02010 P Permease protein COG0609 Cluster_86821 V1218870 GATA map00970,map01100 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) COG0154 Cluster_128892 V1218871 VMRA V Mate efflux family protein COG0534 Cluster_446986 V1218873 YTQB map00340,map00350,map00624,map01120 Q rRNA Methylase COG0500 Cluster_154453 V1218874 YTFP S hi0933 family COG2081 Cluster_269738 V1218875 CMK map00240,map00410,map00770,map01100,map01110 F Cytidine monophosphate kinase COG0283 Cluster_89507 V1218876 MURE map00300,map00550,map01100 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_154454 V1218878 PAC S PAC2 family 0XNTG Cluster_332050 V1218879 NAGB map00520,map01100,map01110 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COG0363 Cluster_102253 V1218880 LMRB P Drug resistance transporter EmrB QacA 0ZVC8 Cluster_232428 V1218881 ACEE map00010,map00020,map00620,map00650,map01100,map01110,map01120 C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) COG2609 Cluster_394764 V1218883 MT2317 S Protein of unknown function (DUF3145) 11JAC Cluster_276396 V1218884 MT2318 V Beta-lactamase COG1680 Cluster_24361 V1218885 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_436943 V1218886 S degv family COG1307 Cluster_129613 V1218887 S Transporter Permease Protein 0ZURF Cluster_198889 V1218888 PHOH2 T Phoh family COG1875 Cluster_39630 V1218889 MT3737 S NA 0YAW9 Cluster_300829 V1218892 GG9_0942 L transposase COG2801 Cluster_440949 V1218893 L Transposase 11M0T Cluster_199886 V1218894 PURT map00230,map00670,map01100,map01110 F Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR COG0027 Cluster_545937 V1218895 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_144216 V1218896 HEMZ map00860,map01100,map01110 H coproporphyrinogen III oxidase COG0635 Cluster_526071 V1218897 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_377053 V1218898 LGAS_0604 V Hnh endonuclease 0XUCJ Cluster_236089 V1218901 SERA map00260,map00680,map01100,map01120,map01230 E Dehydrogenase COG0111 Cluster_279062 V1218902 M secretion protein, HlyD family COG0845 Cluster_170324 V1218903 map02010 V ABC-2 type transporter 0ZVIN Cluster_266988 V1218904 map02010 V ABC-2 type transporter 0ZVIN Cluster_809132 V1218905 V abc transporter permease protein 0ZW5X Cluster_361990 V1218906 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_273711 V1218907 T Histidine kinase COG0642 Cluster_378827 V1218908 T response regulator COG0745 Cluster_268390 V1218909 S YitT family COG1284 Cluster_307867 V1218910 PDXK map00750,map01100 H Pyridoxal kinase COG2240 Cluster_150449 V1218911 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_72482 V1218914 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_560743 V1218916 S NA 11YG8 Cluster_436944 V1218919 SCLAV_4066 S NA 11QJK Cluster_793004 V1218920 RV3193C S UPF0182 protein COG1615 Cluster_551896 V1218921 NDK map00230,map00240,map01100,map01110 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) COG0105 Cluster_131123 V1218922 L transposase, IS605 OrfB COG0675 Cluster_105190 V1218925 IROC map02010 V abc transporter COG1132 Cluster_89059 V1218926 map00020,map00310,map00380,map01100,map01110,map01120 C 2-oxoglutarate dehydrogenase, E1 subunit COG0567 Cluster_140509 V1218928 SPOVK O AAA ATPase, central domain protein COG0464 Cluster_766219 V1218929 S Abi-like protein 11VSQ Cluster_166141 V1218934 S NA 0YF9C Cluster_389413 V1218935 S NA 0YN8E Cluster_350556 V1218936 S NA 0YJH0 Cluster_108795 V1218937 GLPD1 map00564 C Glycerol-3-phosphate dehydrogenase COG0578 Cluster_224331 V1218938 EAPA map00565,map01100,map04146 C FAD linked oxidase domain protein COG0277 Cluster_875908 V1218939 S NA 0ZIXX Cluster_298179 V1218941 ELI_3039 K RNA Polymerase 1261F Cluster_322953 V1218944 S Pfam:DUF1994 0XRWZ Cluster_617869 V1218947 S Protein of unknown function (DUF1292) 1248N Cluster_469337 V1218948 MT1505 map02010 V ABC transporter COG1131 Cluster_64020 V1218949 MPTB S Membrane 0XTGY Cluster_599608 V1218950 S NA 0Y86C Cluster_502304 V1218951 YBBK J Purine nucleoside phosphorylase COG1683 Cluster_78408 V1218955 PROTEASE map05120 O peptidase, U32 COG0826 Cluster_596095 V1218956 SORA C Superoxide reductase COG2033 Cluster_126802 V1218957 E amidohydrolase COG1473 Cluster_113504 V1218958 V Mate efflux family protein COG0534 Cluster_280368 V1218960 V transporter, permease 10BP7 Cluster_417946 V1218961 SIGC K rna polymerase sigma factor COG1595 Cluster_438977 V1218962 S NA 0XXJW Cluster_537310 V1218964 S NA 11TBU Cluster_205048 V1218965 S relaxase mobilization nuclease domain protein 0XNXG Cluster_614095 V1218966 S NA 11NGD Cluster_127492 V1218975 LYSP E permease COG0833 Cluster_152883 V1218976 CRTL map00363,map00624,map00627,map00903,map00906,map00945,map01100,map01110,map01120 I LycopEne 0XPIY Cluster_769955 V1218977 YBIT S ABC transporter COG0488 Cluster_90422 V1218978 M Cell wall anchor domain protein 11Q8J Cluster_499770 V1218980 S Inherit from NOG: Ribosomal protein 1272F Cluster_265676 V1218982 RBSK map00030 G ribokinase COG0524 Cluster_805093 V1218986 PARB K parb-like partition protein COG1475 Cluster_158691 V1218988 S NIF3 (NGG1p interacting factor 3) COG3323 Cluster_295435 V1218989 COBC map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01230 E Aminotransferase COG0079 Cluster_12958 V1218990 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_182988 V1218991 PGN_0050 S NA 0XNWW Cluster_738005 V1218992 PGN_0051 S NA 0YP2S Cluster_421514 V1218993 SCLAV_1351 M Secreted protein COG0791 Cluster_245159 V1218994 TRXB map00240,map00450 O thioredoxin reductase COG0492 Cluster_111430 V1218995 L Integrase COG0582 Cluster_813116 V1218999 ATPG map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) COG0224 Cluster_97882 V1219000 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_199887 V1219001 RARA L recombination factor protein RarA COG2256 Cluster_63461 V1219002 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_157817 V1219003 UGPB map02010 G extracellular solute-binding protein family 1 COG1653 Cluster_344115 V1219004 GLPQ map00564 C glycerophosphoryl diester phosphodiesterase COG0584 Cluster_300830 V1219006 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_141265 V1219008 FRUA map00051,map01100,map02060 G PTS System COG1762 Cluster_226629 V1219009 FRUK map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G 1-phosphofructokinase COG1105 Cluster_22870 V1219010 FTSK D cell division protein FtsK COG1674 Cluster_813117 V1219011 TERC P integral membrane protein, terc COG0861 Cluster_249047 V1219012 S tetrapyrrole methylase COG3956 Cluster_230090 V1219013 DAPF E Diaminopimelate epimerase COG0253 Cluster_789210 V1219014 PCRA map03420,map03430 L DNA helicase COG0210 Cluster_13778 V1219015 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_268391 V1219016 THIG map00730,map01100 H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) COG2022 Cluster_762250 V1219017 THIS map04122 H Thiamine biosynthesis protein thiS 0ZZQD Cluster_236090 V1219018 THIO map00730 E glycine oxidase COG0665 Cluster_115561 V1219019 K Inherit from COG: Transcriptional regulator COG2865 Cluster_419717 V1219021 Y1676 S DUF218 domain COG1434 Cluster_312252 V1219022 PAAF map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00630,map00640,map00650,map00720,map00903,map00930,map01100,map01110,map01120,map01220 I Enoyl-CoA hydratase COG1024 Cluster_318426 V1219023 S cyclase, family COG1878 Cluster_279064 V1219024 O Erythromycin esterase COG2312 Cluster_796951 V1219025 D, J addiction module toxin, RelE StbE family COG2026 Cluster_309282 V1219026 DRAG O ADP-ribosylation crystallin J1 COG1397 Cluster_434889 V1219027 CHRA P Chromate COG2059 Cluster_531625 V1219030 YAJC map03060,map03070 U preprotein translocase, subunit YajC COG1862 Cluster_569973 V1219031 S NA 0Z261 Cluster_528837 V1219032 S Rubrerythrin 12ADX Cluster_669756 V1219033 S NA 12840 Cluster_523151 V1219034 M acetyltransferase COG1247 Cluster_218462 V1219035 I Diacylglycerol kinase COG1597 Cluster_585938 V1219036 RNFA C Electron transport complex COG4657 Cluster_109427 V1219037 FUMC map00020,map00720,map01100,map01110,map01120,map05200,map05211 C fumarate hydratase class II COG0114 Cluster_107631 V1219038 S s-layer domain-containing protein 122G9 Cluster_754960 V1219039 K Transcriptional regulator 120E9 Cluster_253998 V1219041 map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) COG1156 Cluster_124096 V1219042 ILVD map00290,map00770,map01100,map01110,map01210,map01230 E Dihydroxy-acid dehydratase COG0129 Cluster_348939 V1219043 S NA 0YS7C Cluster_456892 V1219044 S Membrane COG2259 Cluster_353722 V1219045 BLT G major facilitator superfamily 0ZVHM Cluster_548994 V1219046 L mutator MutT protein COG0494 Cluster_73148 V1219047 L type iii restriction protein res subunit COG3886 Cluster_93295 V1219048 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_370331 V1219049 MT1047 K Tetr family transcriptional regulator 0XSTJ Cluster_603176 V1219050 GLPX map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120 G Fructose-1,6-bisphosphatase COG1494 Cluster_371951 V1219051 YFHF M epimerase COG4276 Cluster_102798 V1219052 GLMU map00520,map01100,map01110 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) COG1207 Cluster_330487 V1219053 NPDA map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_563697 V1219054 S Zn-finger containing protein 121ND Cluster_273712 V1219055 SSCG_06117 S degv family COG1307 Cluster_117715 V1219056 CG2284 C uridylyltransferase COG1085 Cluster_769956 V1219057 GDHA map00250,map00330,map00910,map01100 E Glutamate dehydrogenase COG0334 Cluster_367006 V1219058 MGTC S MgtC SapB transporter COG1285 Cluster_751510 V1219059 S NA 0Y39F Cluster_385868 V1219060 HISB map00340,map01100,map01110,map01230 E imidazole-glycerol-phosphate dehydratase COG0131 Cluster_148084 V1219061 G Major Facilitator superfamily 11Q79 Cluster_228942 V1219063 RUMA map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_288690 V1219064 S NA 0Y1DS Cluster_176130 V1219065 FECD map02010 P ABC transporter permease COG0609 Cluster_592613 V1219066 FECE map02010 P ABC transporter COG1120 Cluster_754961 V1219067 TNPB L integrase catalytic COG2801 Cluster_777350 V1219068 TNPB L integrase catalytic COG2801 Cluster_265677 V1219069 PSTC map02010 P phosphate abc transporter COG0573 Cluster_15404 V1219070 HRPA L ATP-dependent helicase COG1643 Cluster_39149 V1219071 S NA 11MYY Cluster_394765 V1219072 S Signal transduction histidine kinase, lyts 11GMZ Cluster_335047 V1219073 map02010 P Cobalt transport protein COG0619 Cluster_284484 V1219074 CBIO2 map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_428989 V1219075 CBIO1 map02010 P ABC transporter COG1122 Cluster_326027 V1219077 RSEP map04112 M Membrane-associated zinc metalloprotease COG0750 Cluster_180323 V1219078 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_22353 V1219079 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_442963 V1219080 V type i restriction COG0732 Cluster_206124 V1219083 SP_1222 V restriction endonuclease 0ZVJ1 Cluster_242531 V1219084 TRXB map00240,map00450 O thioredoxin reductase COG0492 Cluster_892129 V1219085 GRDA S reductase complex 0XWGN Cluster_360423 V1219086 TRMK S SAM-dependent methyltransferase COG2384 Cluster_146513 V1219087 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_139781 V1219088 MT1736 S thiamin pyrophosphokinase catalytic COG4825 Cluster_674148 V1219091 COBC map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01230 E Aminotransferase COG0079 Cluster_531626 V1219092 PTPA T protein tyrosine phosphatase COG0394 Cluster_382328 V1219093 THIE map00730,map01100 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) COG0352 Cluster_551897 V1219094 S NA 0Y3IW Cluster_617870 V1219095 K Transcriptional regulator, GntR family COG1725 Cluster_333542 V1219096 FAT map00061,map01100 I Acyl-ACP thioesterase COG3884 Cluster_262964 V1219097 SERB map00260,map00680,map01100,map01120,map01230 E phosphoserine phosphatase COG3830 Cluster_341005 V1219098 ISPD map00900,map01100,map01110 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COG1211 Cluster_502305 V1219099 RIMP S Required for maturation of 30S ribosomal subunits (By similarity) COG0779 Cluster_221974 V1219100 YQFA S UPF0365 protein COG4864 Cluster_203970 V1219101 S NA 0ZN4K Cluster_65394 V1219102 TREZ map00500,map01100,map01110 G maltooligosyl trehalose trehalohydrolase COG0296 Cluster_705346 V1219103 S NA 128RN Cluster_166142 V1219106 GSPE map03070 U type ii secretion system protein e COG2804 Cluster_171149 V1219111 YLBM S UPF0348 protein COG1323 Cluster_16557 V1219112 XYLS map00052,map00500,map01100 G hydrolase, family 31 COG1501 Cluster_557679 V1219113 OCAR_5646 S Protein of unknown function DUF126 COG1786 Cluster_200888 V1219114 G Bacterial extracellular solute-binding protein, family 7 COG1638 Cluster_296778 V1219115 AROF map00400,map01100,map01110,map01230 E phospho-2-dehydro-3-deoxyheptonate aldolase COG2876 Cluster_67524 V1219116 T Histidine kinase 0XNMH Cluster_105191 V1219117 BIOA map00780,map01100 H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) COG0161 Cluster_357087 V1219118 BIOD map00780,map01100 H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) COG0132 Cluster_820701 V1219119 GLNE O, T Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) COG1391 Cluster_851749 V1219121 G Major Facilitator superfamily 0XPEM Cluster_227762 V1219123 NRNA J phosphoesterase RecJ domain protein COG0618 Cluster_599609 V1219124 RBFA J Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) COG0858 Cluster_341006 V1219125 LGAS_0583 S Replication Protein 0YVZX Cluster_114201 V1219126 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_280369 V1219127 DAPA map00300,map01100,map01110,map01120,map01230 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) COG0329 Cluster_107052 V1219128 GLYQS map00970 J Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) COG0423 Cluster_446987 V1219131 S NA 11XFF Cluster_64575 V1219132 ABIR S abortive phage infection 0XQE9 Cluster_444943 V1219133 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_214998 V1219134 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_189023 V1219135 E, T Extracellular solute-binding protein family 3 0YHUR Cluster_430961 V1219136 PKNG map05152 T Serine Threonine protein kinase COG0515 Cluster_37491 V1219137 V ATPase associated with various cellular activities aaa_5 COG1401 Cluster_408822 V1219138 KDPC map02020 P One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) COG2156 Cluster_333543 V1219139 KDPE map02020 T Response regulator receiver domain protein COG0745 Cluster_785213 V1219143 S NA 0ZYXP Cluster_41695 V1219144 MGTE P magnesium transporter COG2239 Cluster_302219 V1219146 map00561,map01100 S Secretory lipase 0YTM1 Cluster_370332 V1219147 LIPS2 map00561,map01100 S Secretory lipase 0YTM1 Cluster_427093 V1219148 COBN map00860,map01100 H cobaltochelatase, cobn subunit COG1429 Cluster_269739 V1219149 UGPE map02010 P ABC transporter COG0395 Cluster_262965 V1219150 UGPA map02010 P binding-protein-dependent transport systems inner membrane Component COG1175 Cluster_196149 V1219151 HEPT map00900,map01110 H synthase COG0142 Cluster_213817 V1219152 RV0561C map00860,map00900,map01100,map01110 C geranylgeranyl reductase COG0644 Cluster_365301 V1219153 TLPA O Thioredoxin family COG0526 Cluster_112038 V1219154 APEA map00480,map01100 E M18 family aminopeptidase COG1362 Cluster_193483 V1219155 RV3230C C oxidoreductase COG1018 Cluster_171150 V1219156 BDHA map00010,map00051,map00071,map00350,map00363,map00591,map00625,map00626,map00650,map00830,map00980,map00982,map01100,map01110,map01120 C alcohol dehydrogenase COG1979 Cluster_599610 V1219157 C Alcohol dehydrogenase zinc-binding domain protein COG1063 Cluster_249048 V1219158 COBW S Cobalamin synthesis protein cobW C-terminal domain COG0523 Cluster_473597 V1219159 MUG map03410 L U mismatch-specific DNA glycosylase COG3663 Cluster_189883 V1219160 COBD map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01230 E decarboxylase COG0079 Cluster_487262 V1219162 CARD K Transcriptional regulator (CarD family COG1329 Cluster_316855 V1219163 PGL map00030,map01100,map01110,map01120 G 6-phosphogluconolactonase (EC 3.1.1.31) COG0363 Cluster_109428 V1219164 RV1842C P integral membrane protein COG1253 Cluster_164492 V1219165 RHLE map03018 L atp-dependent rna helicase COG0513 Cluster_526072 V1219167 COMGF U comG operon protein 6 COG4940 Cluster_233697 V1219169 YTXK L Adenine-specific COG0827 Cluster_80162 V1219170 map00550,map01100 M glycosyl transferase, family 51 COG0744 Cluster_394766 V1219171 TRAK S Conjugative transposon TraK protein 0YYBW Cluster_674149 V1219172 TRAL S NA 11MPG Cluster_116996 V1219173 TRAM S Conjugative transposon TraM protein 0XQI8 Cluster_632863 V1219174 map02010 K Transcriptional regulator 10Z7N Cluster_262966 V1219175 S Inherit from COG: Aminoglycoside phosphotransferase COG3173 Cluster_531627 V1219176 S NA 11TBU Cluster_192598 V1219177 S relaxase mobilization nuclease domain protein 0XNXG Cluster_396553 V1219178 ENTB Q isochorismatase COG1335 Cluster_537311 V1219179 MSRB O reductase COG0229 Cluster_687560 V1219180 DAPE map00300,map00330,map01100,map01110,map01120,map01210,map01230 E succinyl-diaminopimelate desuccinylase COG0624 Cluster_218463 V1219182 DAPD map00300,map01100,map01120,map01230 E Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) COG2171 Cluster_377054 V1219183 PNUC H nicotinamide mononucleotide transporter COG3201 Cluster_132643 V1219185 S integral membrane protein 11VP2 Cluster_77816 V1219186 S smc domain-containing protein 0XTF4 Cluster_36870 V1219187 PRTP O peptidase S8 and S53, subtilisin, kexin, sedolisin COG2247 Cluster_20679 V1219188 V restriction enzyme COG1002 Cluster_454956 V1219189 KDSD M Arabinose 5-phosphate isomerase COG0794 Cluster_24823 V1219190 S Inherit from NOG: Histidine triad protein 11G35 Cluster_925408 V1219191 S NA 11FFJ Cluster_440950 V1219193 S peptidase C60 sortase A and B 128TE Cluster_531628 V1219195 ECHA3 map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120 I Enoyl-CoA hydratase COG1024 Cluster_232429 V1219196 SCLAV_4612 D Chromosome partitioning ATPase COG0455 Cluster_355395 V1219197 S Membrane 11K10 Cluster_25900 V1219198 V Type III COG3587 Cluster_220811 V1219200 RDGB map00230,map00240,map01100 F Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) COG0127 Cluster_458860 V1219201 YSNB S Phosphodiesterase, mj0936 family COG0622 Cluster_96809 V1219202 GATA map00970,map01100 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) COG0154 Cluster_33525 V1219203 NRDE map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_773620 V1219204 NRDE map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_324526 V1219205 PPID O Peptidyl-prolyl cis-trans isomerase COG0760 Cluster_305170 V1219206 AROE map00400,map01100,map01110,map01230 E shikimate COG0169 Cluster_169460 V1219208 DUSB J Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_66578 V1219209 TEX K domain protein COG2183 Cluster_284485 V1219210 S NA 0XZ8I Cluster_871825 V1219211 CG1711 C Aldo keto reductase COG0667 Cluster_116289 V1219212 MSHC map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_68895 V1219213 ARGS map00970 J arginyl-trna synthetase COG0018 Cluster_77817 V1219214 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_515153 V1219215 HSDS V restriction modification system DNA specificity COG0732 Cluster_80163 V1219217 L Site-specific recombinase COG1961 Cluster_617871 V1219218 S recombinase 11R6K Cluster_114202 V1219219 map02010 P ABC transporter COG1122 Cluster_300831 V1219220 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_327591 V1219221 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_303663 V1219222 PURC map00230,map01100,map01110 F SAICAR synthetase COG0152 Cluster_124097 V1219223 FADA2 map00071,map00072,map00280,map00281,map00310,map00350,map00362,map00380,map00592,map00620,map00627,map00630,map00640,map00642,map00650,map00720,map00900,map00903,map01100,map01110,map01120,map02020 I Acetyl-COA acetyltransferase COG0183 Cluster_674150 V1219225 map02020 V ABC transporter, permease COG0577 Cluster_206125 V1219226 OCAR_5486 H Molybdopterin binding domain protein COG0303 Cluster_387713 V1219227 I PAP2 Family COG0671 Cluster_115562 V1219230 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_430962 V1219231 P Chromate transport protein COG2059 Cluster_112764 V1219232 L integrase family 0ZJHZ Cluster_425160 V1219235 XPT map00230,map01100,map01110 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) COG0503 Cluster_55245 V1219236 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_38834 V1219237 MRCA map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_305171 V1219238 POTC map02010 P putrescine abc transporter COG1177 Cluster_438978 V1219239 RECX S Modulates RecA activity (By similarity) COG2137 Cluster_148823 V1219240 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG1372 Cluster_232430 V1219243 O Peptidase, M22 COG0533 Cluster_629041 V1219244 FUR P uptake regulator, fur family COG0735 Cluster_560744 V1219245 FTSL S Cell division protein FtsL 0XTK5 Cluster_239880 V1219246 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_321386 V1219247 THIE map00730,map01100 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) COG0352 Cluster_629042 V1219248 S Cupin 2, conserved barrel domain protein COG1917 Cluster_350557 V1219249 TRKA P domain protein COG0569 Cluster_313742 V1219250 MT0235 map00051 M glycosyl transferase group 1 COG0438 Cluster_68562 V1219251 MT0236 S conserved transmembrane protein 0ZV9J Cluster_434890 V1219253 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_48535 V1219254 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_867879 V1219255 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_253999 V1219257 S NA 1241G Cluster_104597 V1219260 APEA map00480,map01100 E M18 family aminopeptidase COG1362 Cluster_692090 V1219261 P cation diffusion facilitator family transporter COG0053 Cluster_62373 V1219262 S Abortive infection phage resistance protein 0YGER Cluster_64842 V1219263 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_85537 V1219264 S Conserved domain protein 0Y57B Cluster_156104 V1219266 SBND G Major Facilitator 0ZVCH Cluster_138240 V1219267 S NA 121Y4 Cluster_339551 V1219268 GLNQ E abc transporter atp-binding protein COG1126 Cluster_585939 V1219271 V Hnh endonuclease COG1403 Cluster_428990 V1219272 S Protein of unknown function (DUF1706) COG4283 Cluster_573187 V1219273 RV1042C L Transposase COG3293 Cluster_517824 V1219274 SSNG_01961 L Transposase COG3293 Cluster_86378 V1219277 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Involved in acetate metabolism (By similarity) COG0280 Cluster_188179 V1219278 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_517825 V1219279 S NA 11QKP Cluster_560745 V1219280 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_165334 V1219282 L Helicase COG4581 Cluster_48536 V1219283 MRCB map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_148085 V1219284 ATHE_0092 S Uncharacterised protein family (UPF0236) 0XRR3 Cluster_363558 V1219288 K Tetr family transcriptional regulator 11MWV Cluster_375283 V1219290 ATPA map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_292651 V1219291 ATPH map00190,map00195,map01100 C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) COG0712 Cluster_430963 V1219292 ATPF map00190,map00195,map01100 C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) COG0711 Cluster_153653 V1219293 S NA 11IN7 Cluster_560746 V1219294 S toxin secretion phage lysis holin COG4824 Cluster_298180 V1219295 M Cpl-7 lysozyme C-terminal domain protein 11GG1 Cluster_25309 V1219296 V Type I restriction-modification system R subunit COG4096 Cluster_341007 V1219298 LGT M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 Cluster_338120 V1219299 CPN_0573 K transcriptional regulatory protein COG0217 Cluster_338121 V1219300 NADE map00760,map01100 H nh(3)-dependent nad( ) synthetase COG0171 Cluster_456893 V1219302 CKL_1924 S Predicted membrane protein (DUF2335) COG5346 Cluster_380556 V1219303 SSCG_04455 S Methyltransferase 0XSGP Cluster_307868 V1219304 ETFB map00910 C Electron transfer flavoprotein COG2086 Cluster_42775 V1219307 S Inherit from NOG: LPXTG-motif cell wall anchor domain protein 0YEBJ Cluster_127493 V1219309 RARA L recombination factor protein RarA COG2256 Cluster_147285 V1219310 GLTS E Sodium Glutamate Symporter COG0786 Cluster_540118 V1219311 RARA L recombination factor protein RarA COG2256 Cluster_207232 V1219316 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_329088 V1219318 HSDM V type I restriction-modification system COG0286 Cluster_224332 V1219319 RV0224C map00340,map00350,map00624,map01120 S methyltransferase 0XTDB Cluster_566892 V1219320 MT0235 map00051 M glycosyl transferase group 1 COG0438 Cluster_44660 V1219322 FTSI map00550,map01100 M penicillin-binding protein COG0768 Cluster_221977 V1219324 S Nucleotidyl transferase of unknown function (DUF1814) 0XP6B Cluster_382329 V1219325 PLAV_1224 S NA 0ZTDK Cluster_579513 V1219327 GTO2 O Glutathione S-transferase COG0435 Cluster_384104 V1219328 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_724879 V1219331 CYSK map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_332051 V1219332 YQEC S selenium-dependent hydroxylase accessory protein YqeC 11VFN Cluster_396555 V1219333 ILVB map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E acetolactate synthase COG0028 Cluster_156105 V1219335 TOPB L Dna topoisomerase COG0550 Cluster_238610 V1219337 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_167680 V1219338 map00561,map01100 M Glycosyl transferase (Group 1 COG0438 Cluster_394767 V1219339 YJBF S SNARE-like domain protein COG0398 Cluster_26781 V1219340 MTSD S NA 17UZ3@proNOG Cluster_714957 V1219341 L Addiction module antitoxin, RelB DinJ family COG3077 Cluster_27462 V1219342 TRAG map03070 U TraG TraD family protein COG3505 Cluster_100012 V1219344 MURE map00300,map00550 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_427094 V1219345 TETR K Tetr family transcriptional regulator 104NP Cluster_318428 V1219347 T Histidine kinase COG0642 Cluster_548995 V1219348 S Toxin-antitoxin system, antitoxin component, HicB family 12518 Cluster_828520 V1219349 S conserved domain protein 1280C Cluster_55497 V1219350 O cysteine protease COG4870 Cluster_537312 V1219352 M Arylsulfatase COG1368 Cluster_64021 V1219353 THRE S Amino acid export carrier protein COG3610 Cluster_168529 V1219354 CSD map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_54752 V1219355 TREY map00500,map01100,map01110 G malto-oligosyltrehalose synthase COG3280 Cluster_606784 V1219356 L Recombinase COG1961 Cluster_463028 V1219359 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_44487 V1219360 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_606785 V1219361 HSDS V type I restriction modification DNA specificity domain COG0732 Cluster_341008 V1219362 V ABC transporter, ATP-binding permease protein COG1132 Cluster_79157 V1219363 PEAH map02010 V ABC transporter, ATP-binding protein COG1132 Cluster_303664 V1219364 SCPA S Segregation and condensation protein COG1354 Cluster_266989 V1219365 SOJ D cobyrinic Acid a,c-diamide synthase COG1192 Cluster_367008 V1219369 YGFZ map00260,map00670,map00910,map01100 S Folate-binding protein YgfZ COG0354 Cluster_257723 V1219370 PABC map00280,map00290,map00770,map00790,map01100,map01110,map01210,map01230 E Aminotransferase COG0115 Cluster_370333 V1219371 I May play a role in the intracellular transport of hydrophobic ligands 11G4X Cluster_371952 V1219372 S Chromosome segregation ATPase 11HKQ Cluster_284486 V1219373 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_394768 V1219374 S nuclear export factor GLE1 COG4549 Cluster_499771 V1219375 MHQR K transcriptional regulator), MarR family 11UT8 Cluster_425161 V1219376 S Nitroreductase COG3560 Cluster_28066 V1219377 ACNA map00020,map00300,map00630,map00720,map01100,map01110,map01120,map01210,map01230 C aconitate hydratase COG1048 Cluster_145717 V1219378 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_148086 V1219379 SCLAV_0831 E alanine racemase domain protein COG3616 Cluster_206126 V1219380 GULO map00053,map01100 C oxidoreductase COG0277 Cluster_401789 V1219382 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_230091 V1219383 C Alcohol dehydrogenase zinc-binding domain protein COG0604 Cluster_661274 V1219385 S Pfam:Phage_QLRG 0XZ9J Cluster_648837 V1219386 YERC S protein, YerC YecD COG4496 Cluster_661275 V1219387 S NA 0XW7Q Cluster_319909 V1219388 KDPD map02020 T Osmosensitive K channel His kinase sensor COG2205 Cluster_62085 V1219389 V ABC transporter COG1132 Cluster_28863 V1219390 M domain protein COG4932 Cluster_34030 V1219391 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_97357 V1219392 PBUX F permease COG2233 Cluster_143467 V1219393 G Major Facilitator superfamily 0XPEM Cluster_231268 V1219394 E, H Thiamine pyrophosphate COG0028 Cluster_171969 V1219395 AARI_34710 L Transposase for insertion sequence 11IYJ Cluster_417947 V1219399 CARD K Transcriptional regulator (CarD family COG1329 Cluster_103424 V1219400 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_306559 V1219401 PPP map03070 T phosphatase COG0631 Cluster_254000 V1219402 I Diacylglycerol kinase COG1597 Cluster_523152 V1219403 S NA 0XWY0 Cluster_419719 V1219404 EBA2484 L AtP-binding protein COG1484 Cluster_68220 V1219405 MAQU_3187 L Integrase catalytic subunit COG4584 Cluster_250308 V1219406 S NA 0Z3WT Cluster_133480 V1219407 O AAA ATPase, central domain protein COG0464 Cluster_209401 V1219409 map00190,map00680,map01100 C ATP synthase (C/AC39) subunit 0ZXSZ Cluster_237294 V1219410 CORA P transporter COG0598 Cluster_363559 V1219411 YBJB S integral membrane protein COG4858 Cluster_754962 V1219412 RPSR map03010 J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) COG0238 Cluster_322955 V1219413 I CoA-substrate-specific enzyme activase COG1924 Cluster_303665 V1219414 S NA 0Y843 Cluster_96291 V1219417 V Restriction modification system DNA specificity domain protein COG0732 Cluster_621533 V1219418 S NA 0Y8FU Cluster_606787 V1219419 GCDC map00010,map00020,map00362,map00620,map00650,map01100,map01110,map01120 I biotin lipoyl attachment domaiN-containing protein COG0511 Cluster_170325 V1219420 Y3785 S Uncharacterized protein conserved in bacteria N-term (DUF3322) COG4924 Cluster_199888 V1219421 SBCC3 S Cytosolic protein COG4913 Cluster_391144 V1219422 CAS1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) COG1518 Cluster_809134 V1219423 FADD4 map00071,map01100,map03320,map04146,map04920 Q Amp-dependent synthetase and ligase COG0318 Cluster_95205 V1219424 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_305172 V1219426 T Histidine kinase COG4585 Cluster_678598 V1219427 SSCG_03030 map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_199889 V1219428 S NA 0Z59Q Cluster_170326 V1219429 AROA map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate synthase COG0128 Cluster_542993 V1219430 P Ferric uptake regulator, Fur family COG0735 Cluster_315327 V1219431 O Dehydrogenase COG1975 Cluster_295437 V1219432 YQEB O Selenium-dependent molybdenum hydroxylase system protein, YqeB family COG1975 Cluster_545938 V1219433 S NA 11ZGT Cluster_53279 V1219434 PROTEASE map05120 O Peptidase U32 COG0826 Cluster_219623 V1219435 S Pilin isopeptide linkage domain protein 1274N Cluster_456894 V1219436 CYSE map00270,map00920,map01100,map01120,map01230 E serine acetyltransferase COG1045 Cluster_214999 V1219437 S NA 0XTJ4 Cluster_417948 V1219438 SLGD_00062 S membrAne 11F2H Cluster_91864 V1219439 G transporter 0XNQK Cluster_380557 V1219440 UBIE map00130,map01100,map01110 H Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) COG2226 Cluster_156950 V1219441 MGTA map00051 M Glycosyl transferase (Group 1 COG0438 Cluster_211611 V1219442 ASNA map00250,map00460,map00910,map01100,map01110,map01230 E asparagine synthetase A COG2502 Cluster_648838 V1219443 SPOVG M Could be involved in septation (By similarity) COG2088 Cluster_89974 V1219444 L site-specific recombinase COG1961 Cluster_557680 V1219445 L Resolvase, N-terminal domain protein COG1961 Cluster_31843 V1219446 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_106414 V1219447 S RelA SpoT domain protein 0XPFE Cluster_252743 V1219448 I Lipid kinase, YegS Rv2252 BmrU family COG1597 Cluster_355396 V1219450 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_342527 V1219451 K Iclr family transcriptional regulator 11XKS Cluster_442964 V1219452 K Tetr family transcriptional regulator 11SFF Cluster_644781 V1219453 P multidrug resistance protein 126BZ Cluster_589250 V1219454 S NA 0ZS1W Cluster_227763 V1219457 S surface protein 11NE4 Cluster_375284 V1219458 VNCR T response regulator COG0745 Cluster_440951 V1219459 VEX3 V abc transporter permease protein COG0577 Cluster_494602 V1219460 S NA 125SF Cluster_449009 V1219461 WECD map00350,map00362,map00627,map00642,map00903,map01120 S -acetyltransferase 11PF0 Cluster_32309 V1219462 METH map00270,map00450,map00670,map01100,map01110,map01230 E Methionine synthase COG1410 Cluster_855527 V1219463 S single-strand binding family protein 0XS6K Cluster_218464 V1219464 K AraC Family Transcriptional Regulator COG2207 Cluster_247741 V1219465 U, W Hep Hag repeat protein COG5295 Cluster_66858 V1219466 GYRA2 L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_731458 V1219468 RPMC map03010 J 50s ribosomal protein l29 COG0255 Cluster_132644 V1219469 MGTE P magnesium transporter COG2239 Cluster_370334 V1219470 S Methyltransferase 11PHP Cluster_275064 V1219471 S NA 11HU2 Cluster_350558 V1219474 MT1102 S membrane COG4760 Cluster_563698 V1219476 Y2191 K Antirepressor COG3617 Cluster_291295 V1219477 S FhuF 2Fe-2S C-terminal domain 0XWKM Cluster_271051 V1219478 MT1287 S NA 11QDU Cluster_184680 V1219481 S Band 7 protein COG2268 Cluster_252744 V1219482 PROB map00330,map01100,map01230 E Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) COG0263 Cluster_216130 V1219483 E amidohydrolase COG1473 Cluster_176954 V1219484 E peptidase COG2195 Cluster_172877 V1219485 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_198890 V1219486 POTA map02010 E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COG3842 Cluster_446988 V1219487 PUUR K Transcriptional regulator COG1396 Cluster_652924 V1219489 LICA map02060 G PTS System COG1447 Cluster_657042 V1219490 LICB map02060 G PTS System COG1440 Cluster_257724 V1219491 S PEP phosphonomutase family protein 0XPW8 Cluster_208353 V1219492 K Transcriptional Regulator AraC Family 0ZYR5 Cluster_139782 V1219493 CODA map00240,map00330,map00791,map01100,map01120 F cytosine deaminase COG0402 Cluster_265678 V1219496 REP L Replication Protein COG5527 Cluster_243881 V1219498 YRRN map05120 O peptidase (U32 family) COG0826 Cluster_34197 V1219499 IROC map02010 V abc transporter COG1132 Cluster_566893 V1219500 S NA 0YSYB Cluster_236091 V1219501 S NA 11HGS Cluster_517826 V1219502 TRAA L TrwC relaxase COG0507 Cluster_380558 V1219503 RPLY map03010 J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) COG1825 Cluster_344116 V1219505 YABB map00340,map00350,map00624,map01120 L Methyltransferase COG4123 Cluster_281711 V1219506 YAAT S psp1 domain protein COG1774 Cluster_59074 V1219508 DXS map00730,map00900,map01100,map01110 H, I Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) COG1154 Cluster_163684 V1219511 SCLAV_3035 S Abi-like protein 11WV5 Cluster_186481 V1219512 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_480350 V1219513 GUAB1 map00230,map00983,map01100,map01110 F Dehydrogenase COG0517 Cluster_179503 V1219514 GLSA map00250,map00330,map00471,map00910,map01100,map01120,map04724,map04727,map04964 E Glutaminase COG2066 Cluster_421515 V1219516 S ATP GTP-binding protein 0XNYD Cluster_368621 V1219518 S NA 1119B Cluster_262967 V1219519 CRTB map00906,map01062,map01100,map01110 I phytoene synthase COG1562 Cluster_72822 V1219520 SSMG_01709 L transposase COG2826 Cluster_223156 V1219521 LIVM map02010 E amino acid COG4177 Cluster_378828 V1219524 MTSD S NA 17UZ3@proNOG Cluster_548998 V1219525 P tonB-dependent siderophore receptor COG1629 Cluster_72159 V1219529 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_507285 V1219530 SEPF S Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) COG1799 Cluster_285925 V1219533 map00330,map00360,map00380,map00627,map00643,map01120 Q K01426 amidase EC 3.5.1.4 COG0154 Cluster_285926 V1219534 ISPE map00900,map01100,map01110 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COG1947 Cluster_382330 V1219535 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_463029 V1219536 ISCU C SUF system FeS assembly protein COG0822 Cluster_484988 V1219537 SCLAV_1116 S metal-sulfur cluster biosynthetic COG2151 Cluster_358759 V1219540 S NA 11NM2 Cluster_403567 V1219541 C nitroreductase COG0778 Cluster_592614 V1219542 GST map00480,map00980,map00982,map05204 O Glutathione S-transferase COG0625 Cluster_85913 V1219543 COMM O Mg chelatase subunit ChlI COG0606 Cluster_134268 V1219544 L C-5 cytosine-specific DNA methylase COG0270 Cluster_138241 V1219545 MTAD F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) COG0402 Cluster_36685 V1219549 U, W Pfam:YadA COG5295 Cluster_629043 V1219550 LYSC map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Aspartokinase COG0527 Cluster_287333 V1219551 E, G Membrane COG0697 Cluster_355397 V1219552 LEUA map00290,map00620,map01100,map01110,map01210,map01230 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) COG0119 Cluster_695904 V1219553 S inner membrane protein YbaN COG2832 Cluster_155294 V1219554 KDPD map02020 T Histidine kinase COG2205 Cluster_329089 V1219555 KDPE map02020 T Two component transcriptional regulator, winged helix family COG0745 Cluster_180324 V1219556 CFA M cyclopropane-fatty-acyl-phospholipid synthase COG2230 Cluster_335049 V1219557 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_236092 V1219558 INSI L transposase COG2826 Cluster_114203 V1219559 ACTP E sodium solute COG4147 Cluster_632864 V1219560 SCLAV_1038 S integral membrane protein COG3162 Cluster_855528 V1219561 DKGA C reductase COG0656 Cluster_339552 V1219564 SRTB U sortase, SrtB family COG4509 Cluster_352058 V1219565 CASA L crispr-associated protein 0XPA1 Cluster_81344 V1219566 CYDC map02010 V Abc transporter COG1132 Cluster_537313 V1219567 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_652925 V1219570 FDXA C Ferredoxin COG1146 Cluster_175335 V1219571 DAPC map00300,map01100,map01120,map01230 E Aminotransferase COG0436 Cluster_225507 V1219572 ANSA map00250,map00460,map00910,map01100,map01110 E l-asparaginase (EC 3.5.1.1) COG0252 Cluster_173711 V1219574 ELRF S cutinase 11FQ6 Cluster_450980 V1219575 S secreted protein 11S0R Cluster_699181 V1219578 TNPA L transposase COG4644 Cluster_38134 V1219579 ESSC D ftsk spoIIIe COG1674 Cluster_442965 V1219581 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_148087 V1219584 LGAS_0605 S phage terminase large subunit 0XSCY Cluster_361991 V1219585 YHCW map00500 J HAD-superfamily hydrolase subfamily IA variant 3 COG0637 Cluster_104598 V1219586 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_385869 V1219587 GUAB3 map00230,map00983,map01100,map01110 F Dehydrogenase COG0516 Cluster_94166 V1219588 SUFB O FeS assembly protein SUFB COG0719 Cluster_434891 V1219589 K Transcriptional regulator 120E9 Cluster_200889 V1219590 S NA 0XNQB Cluster_48960 V1219591 S Membrane 0Y2EP Cluster_859530 V1219592 L ABC transporter COG0178 Cluster_512453 V1219593 K Tetr family transcriptional regulator 11SFF Cluster_89508 V1219594 SMVA G major facilitator superfamily COG0477 Cluster_387714 V1219597 S NA 12A75 Cluster_407062 V1219598 S Cutinase 0YUSA Cluster_138987 V1219599 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_492119 V1219600 YJEE S protein family UPF0079, ATPase COG0802 Cluster_225508 V1219601 CZCD P cation diffusion facilitator family transporter COG1230 Cluster_367009 V1219602 SRTA M (sortase) family COG3764 Cluster_107632 V1219604 GLPT map02020 G transporter COG2271 Cluster_330488 V1219605 CPPA S CppA protein 0ZGK6 Cluster_378829 V1219606 C Nitroreductase COG0778 Cluster_373571 V1219607 PFOR S Membrane COG3641 Cluster_569974 V1219609 SARE_3740 K Antirepressor COG3645 Cluster_50360 V1219612 S NA 0XPJ6 Cluster_482664 V1219613 RIMM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) COG0806 Cluster_70237 V1219615 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_161210 V1219616 L transposase 11GFI Cluster_310726 V1219618 G, M Inherit from COG: Capsular polysaccharide biosynthesis protein COG4464 Cluster_40710 V1219619 U, W Pfam:YadA COG5295 Cluster_824685 V1219621 S NA 0ZHU9 Cluster_126803 V1219622 PORAS_0418 L reverse transcriptase COG3344 Cluster_596097 V1219623 RPLN map03010 J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) COG0093 Cluster_731459 V1219624 RPSQ map03010 J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal COG0186 Cluster_796953 V1219625 RPMC map03010 J 50s ribosomal protein l29 COG0255 Cluster_599611 V1219626 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_734679 V1219627 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_114880 V1219628 BL03948 S nucleoside recognition domain protein COG3314 Cluster_844065 V1219629 SECE map03060,map03070 U Preprotein translocase SecE subunit 0XUXP Cluster_256438 V1219631 DNAI L Primosomal protein, DnaI COG1484 Cluster_370335 V1219632 DNAB L replication initiation and membrane attachment COG3611 Cluster_292652 V1219633 YXEH S hydrolase COG0561 Cluster_401790 V1219634 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_566894 V1219636 CDD map00240,map00983,map01100,map05219 F cytidine deaminase COG0295 Cluster_262968 V1219637 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_288691 V1219638 SDHA map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020,map05134 C succinate dehydrogenase, flavoprotein subunit COG1053 Cluster_51325 V1219639 S ATPase domain protein 125CS Cluster_542995 V1219640 K Bacterial regulatory proteins, tetR family COG1309 Cluster_206127 V1219641 PURM map00230,map01100,map01110 F phosphoribosylaminoimidazole synthetase COG0150 Cluster_396556 V1219642 PURF map00230,map00250,map01100,map01110 F glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_322956 V1219643 KDSB map00540,map01100 M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) COG1212 Cluster_371953 V1219644 SITB map02010,map02020 P (ABC) transporter COG1121 Cluster_246482 V1219645 SITA map02010,map02020 P periplasmic solute binding protein COG0803 Cluster_731460 V1219646 UBIE map00130,map01100,map01110 H Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) COG2226 Cluster_348940 V1219647 PYRC map00230,map00240,map00410,map00770,map00983,map01100,map01120 F dihydroorotase COG0044 Cluster_542996 V1219648 ISPG map00900,map01100,map01110 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) COG0821 Cluster_77818 V1219649 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_58038 V1219650 K Fibronectin-binding protein A N-terminus (FbpA) COG1293 Cluster_83394 V1219651 NNRD G Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) COG0063 Cluster_43134 V1219652 M Phage minor structural protein COG4926 Cluster_734680 V1219653 KATA map00380,map00630,map01110,map04146,map05014 P catalase COG0753 Cluster_96810 V1219654 S secreted protein 0YGV2 Cluster_370336 V1219655 COBI map00860,map01100 H Precorrin-2 c20-methyltransferase COG2243 Cluster_377055 V1219656 COBG map00860,map01100 H precorrin-3b synthase COG0155 Cluster_758488 V1219657 Q Mammalian cell entry related domain protein COG1463 Cluster_224333 V1219658 LYSR K transcriptional regulator, lysR family COG0583 Cluster_233698 V1219659 RIMO J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) COG0621 Cluster_497108 V1219660 BPR_I0156 L transposase COG1943 Cluster_867881 V1219661 GLTC K transcriptional regulator COG0583 Cluster_250309 V1219664 S NA 0YCC9 Cluster_551898 V1219667 DEF2 J peptide deformylase COG0242 Cluster_239881 V1219668 SCRK map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G fructokinase COG1940 Cluster_217334 V1219670 P Periplasmic binding protein COG0614 Cluster_465116 V1219671 C Nitroreductase COG0778 Cluster_444944 V1219672 S Acetyltransferase (GNAT) family 11Z04 Cluster_423374 V1219673 PCAD map00362,map01100,map01120 Q 3-oxoadipate enol-lactonase COG0596 Cluster_569976 V1219674 SCLAV_5538 S NA 11XKE Cluster_324528 V1219675 K LysR family Transcriptional regulator COG0583 Cluster_283110 V1219676 COF S hydrolase COG0561 Cluster_236093 V1219677 MT0809 C fumarate reductase succinate dehydrogenase flavoprotein domain protein COG3573 Cluster_166143 V1219679 ADH map00051,map00363,map00591,map00625,map00650,map01100,map01120 C iron-containing alcohol dehydrogenase COG1454 Cluster_205049 V1219681 PPA1638 S abc transporter 0XNT6 Cluster_239882 V1219682 SSCG_03007 S ABC, transporter 0XNW9 Cluster_145718 V1219683 S radical SAM domain protein COG4277 Cluster_403568 V1219684 YQGX map00620 Q domain protein COG0491 Cluster_178625 V1219685 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_396557 V1219686 FXSA S cytoplasmic membrane protein 12942 Cluster_102254 V1219688 NDH map00190 C NADH dehydrogenase COG1252 Cluster_134269 V1219689 PORAS_0418 L reverse transcriptase COG3344 Cluster_382332 V1219690 map02010 P ABC, transporter COG1120 Cluster_173712 V1219691 HMUU map02010 P permease protein COG0609 Cluster_262969 V1219693 FTSX map02010 D Part of the ABC transporter FtsEX involved in cellular division (By similarity) COG2177 Cluster_781091 V1219694 YRXA K 3H domain protein COG1827 Cluster_265679 V1219695 BMUL_3003 S Membrane COG3619 Cluster_603179 V1219696 K Transcriptional regulator, ARAC family COG2207 Cluster_318429 V1219697 LTRA L reverse transcriptase COG3344 Cluster_463030 V1219698 S hydrolase 11G9J Cluster_126098 V1219699 YFMR S abc transporter COG0488 Cluster_143468 V1219700 YAAO map00310,map00330,map00960,map01100,map01110 E decarboxylase COG1982 Cluster_777351 V1219701 V (ABC) transporter COG1131 Cluster_820704 V1219702 UDGA map00040,map00053,map00500,map00520,map01100,map01110 M Udp-glucose 6-dehydrogenase COG1004 Cluster_82121 V1219703 GLT map00630,map00910 E Glutamate synthase COG0069 Cluster_102799 V1219704 S S-layer domain protein 11R54 Cluster_249049 V1219705 RNFB C electron transport complex, RnfABCDGE type, B subunit COG2878 Cluster_203971 V1219706 VIRE2 S Virulence-associated protein e COG5545 Cluster_711582 V1219707 S Abortive infection protein AbiGII 0XQHH Cluster_416141 V1219709 S Abortive infection protein AbiGI 11WH3 Cluster_227764 V1219710 RARD S rard protein COG2962 Cluster_385870 V1219711 S NA 0ZUJG Cluster_355398 V1219712 TRMK S SAM-dependent methyltransferase COG2384 Cluster_465117 V1219714 S NA 0Y65N Cluster_566895 V1219715 TPDA E peptidase COG0624 Cluster_221978 V1219716 GALE map00052,map00520,map01100,map01110 M udp-glucose 4-epimerase COG1087 Cluster_377056 V1219717 IDER K iron (metal) dependent repressor, dtxr family COG1321 Cluster_789213 V1219718 PLSY map00561,map00564,map01100 S Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) COG0344 Cluster_239883 V1219719 ZNUA map02010 P periplasmic solute binding protein COG0803 Cluster_53280 V1219720 NIRK map00910,map01120 Q nitrite reductase COG2132 Cluster_69606 V1219721 NIST map02010 V ABC transporter 0XPIZ Cluster_773624 V1219722 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_73513 V1219723 PARE L Dna topoisomerase iv (Subunit b) COG0187 Cluster_542997 V1219724 LSA_01120 L Transposase COG1943 Cluster_711583 V1219728 VEG S Veg protein COG4466 Cluster_148824 V1219729 SERP0565 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_147286 V1219731 SULP P sulfate transporter COG0659 Cluster_380559 V1219732 S NA 0YE9N Cluster_48074 V1219733 U, W Pfam:YadA COG5295 Cluster_683124 V1219734 RUVX L Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) COG0816 Cluster_260348 V1219736 DCM map00270,map01100 L Inherit from proNOG: cytosine-specific methyltransferase COG0270 Cluster_175336 V1219740 L transposase, IS605 OrfB COG0675 Cluster_373572 V1219741 MGPA S DHH family COG0618 Cluster_425162 V1219742 S NA 0Y7IJ Cluster_748090 V1219743 V Type I restriction modification DNA specificity domain 11G07 Cluster_50361 V1219744 MT3888 S NA 11KBZ Cluster_793009 V1219745 V Abc transporter COG1132 Cluster_277705 V1219747 HBD map00360,map00362,map00650,map01100,map01120 I 3-hydroxyacyl-CoA dehydrogenase COG1250 Cluster_137478 V1219748 HYDF S gtp-binding protein COG1160 Cluster_49581 V1219749 M domain protein COG4932 Cluster_49371 V1219750 M domain protein COG4932 Cluster_417949 V1219751 YHJX G major facilitator superfamily 171GS@proNOG Cluster_321388 V1219752 FDHD C Necessary for formate dehydrogenase activity (By similarity) COG1526 Cluster_610451 V1219753 S Protein of unknown function (DUF2786) 11S2Y Cluster_230092 V1219754 S NA 0XPQF Cluster_288692 V1219755 RV1836C S VWA 11NEC Cluster_220812 V1219756 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_367010 V1219757 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_159543 V1219758 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_438979 V1219759 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_272378 V1219760 STRIC_0432 L Transposase (IS4 family 11HCS Cluster_50160 V1219761 map05132 M repeat protein COG3209 Cluster_836127 V1219762 S Relaxase mobilization nuclease 11PW0 Cluster_117716 V1219763 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_156106 V1219764 GLGC map00500,map00520,map01100,map01110 G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) COG0448 Cluster_124752 V1219765 SP_1683 G ABC, transporter COG1653 Cluster_157818 V1219766 ELI_1299 S Phage major capsid protein COG4653 Cluster_132645 V1219767 FPRA map00250,map00910,map01100,map01110,map01120,map01230 C reductase COG0493 Cluster_569977 V1219770 S Hydrolase COG1011 Cluster_62374 V1219771 MUTB map00280,map00630,map00640,map00720,map01100,map01120 I Methylmalonyl-coA mutase COG2185 Cluster_344117 V1219775 S NA 11US3 Cluster_51525 V1219777 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_148088 V1219780 S NA 0ZKKG Cluster_236094 V1219781 ARCC map00230,map00330,map00910,map01120 E carbamate kinase COG0549 Cluster_665451 V1219782 S phage protein 11QFY Cluster_629044 V1219783 S Phage head-tail adaptor 11JDV Cluster_526073 V1219784 S Phage protein, HK97 gp10 family 11K8D Cluster_674153 V1219785 CRES_0877 S NA 11IZ7 Cluster_718201 V1219786 NLAXM map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_467196 V1219788 MODB map02010 P molybdate abc transporter COG4149 Cluster_683125 V1219789 TMP1 S NA 10C99 Cluster_91376 V1219790 MOD map00340,map00350,map00624,map01120 L DNA methylase COG2189 Cluster_579515 V1219792 S NA 11W9N Cluster_367011 V1219795 RELA map00230 S RelA SpoT domain protein COG2357 Cluster_432970 V1219796 CYAA S Adenylate cyclase COG4116 Cluster_196966 V1219797 CAPA M Capsule synthesis protein COG2843 Cluster_428991 V1219798 RLMH S Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) COG1576 Cluster_195098 V1002001 YLOV S dak2 domain fusion protein ylov COG1461 Cluster_928073 V1002002 ASP S Alkaline-shock protein COG1302 Cluster_331740 V1002003 MALD map02010 P ABC transporter, permease COG3833 Cluster_525342 V1002004 MALC map02010 P permease protein COG1175 Cluster_396172 V1002005 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_528181 V1002006 CODA F deaminase COG0295 Cluster_253768 V1002009 RR07 map02020 T regulatoR COG4753 Cluster_730667 V1002010 HK07 map02020 T Histidine kinase COG2972 Cluster_545168 V1002013 PLSX map00561,map00564,map01100 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) COG0416 Cluster_327247 V1002014 RECO map03440 L Involved in DNA repair and RecF pathway recombination (By similarity) COG1381 Cluster_178470 V1002015 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_660227 V1002016 CINA H competence damage-inducible protein COG1546 Cluster_342176 V1002017 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_519774 V1002019 BDP_0120 L Transposase 11QWX Cluster_456448 V1002020 GG9_0942 L Transposase COG2801 Cluster_170980 V1002021 COPA P p-type ATPase COG2217 Cluster_179316 V1002022 CBPC M choline binding protein COG5263 Cluster_575627 V1002023 VICR map02020 T response regulator COG0745 Cluster_316546 V1002024 VICK map02020 T Histidine kinase 0XNMH Cluster_519775 V1002025 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_403141 V1002026 PANC map00410,map00770,map01100,map01110 H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) COG0414 Cluster_501689 V1002027 FCHA map00670,map01100 E Methenyltetrahydrofolate cyclohydrolase COG3404 Cluster_368276 V1002028 FTCD map00340,map00670,map01100 E Glutamate formiminotransferase COG3643 Cluster_293713 V1002031 S (LipO)protein 0XQK7 Cluster_208125 V1002032 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_647836 V1002033 TRXA O Thioredoxin COG0526 Cluster_343787 V1002034 TRXB map00240,map00450 O thioredoxin reductase COG0492 Cluster_188854 V1002035 S Membrane 11KXQ Cluster_464651 V1002036 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins COG0706 Cluster_493973 V1002037 YIDD S Could be involved in insertion of integral membrane proteins into the membrane (By similarity) COG0759 Cluster_743859 V1002039 SAES map02020 T Histidine kinase COG0642 Cluster_401358 V1002040 RPSD map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) COG0522 Cluster_378429 V1002041 MDLB V ABC transporter COG1132 Cluster_489009 V1002042 MDLA V ABC transporter transmembrane region COG1132 Cluster_174339 V1002043 YYBT T domain protein COG3887 Cluster_635837 V1002044 THIN map00730,map01100 H thiamine COG1564 Cluster_303327 V1002045 RMUC S RmuC domain protein COG1322 Cluster_175156 V1002046 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_176807 V1002047 ESSC D ftsk spoIIIe COG1674 Cluster_867004 V1002048 SPOU J rrna methyltransferase COG0566 Cluster_710738 V1002049 ACYP map00620,map00627,map01120 C Acylphosphatase COG1254 Cluster_446529 V1002050 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) COG0706 Cluster_189700 V1002051 SP_2145 G Alpha-1,2-mannosidase COG3537 Cluster_179317 V1002052 map02010 V ABC transporter COG1132 Cluster_179318 V1002053 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_698453 V1002054 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_747301 V1002055 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_506612 V1002056 RPSE map03010 J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) COG0098 Cluster_180152 V1002057 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_180153 V1002058 BGAA map00040,map00052,map00500,map00511,map00531,map00600,map00860,map00944,map00983,map01100,map04142 G hydrolase family 2, sugar binding COG3250 Cluster_180999 V1002061 CAPA M Capsule synthesis protein COG2843 Cluster_408414 V1002062 AHPC O alkyl hydroperoxide reductase COG0450 Cluster_475198 V1002063 AHPD S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) COG2128 Cluster_195959 V1002064 S Membrane 0Y3RG Cluster_477421 V1002065 YXKA S phospholipid-binding protein COG1881 Cluster_214765 V1002070 METE map00270,map00450,map01100,map01110,map01230 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) COG0620 Cluster_343788 V1002076 METF map00670,map00720,map01100,map01120 E Methylenetetrahydrofolate reductase COG0685 Cluster_327248 V1002077 YVFS map02010 V ABC transporter COG0842 Cluster_664450 V1002078 YVFR map02010 V ABC transporter COG1131 Cluster_366648 V1002079 DEGU map02020 T Two component transcriptional regulator luxr family COG2197 Cluster_668776 V1002080 YPSA S UPF0398 protein COG4474 Cluster_628131 V1002081 GPSB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) COG3599 Cluster_187155 V1002082 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_308983 V1002084 RPSB map03010 J 30S ribosomal protein S2 COG0052 Cluster_217073 V1002086 TAUA map02010 P ABC transporter substrate-binding protein COG0715 Cluster_434417 V1002087 P Chloride channel COG0038 Cluster_602261 V1002088 RPLS map03010 J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) COG0335 Cluster_572378 V1002092 CKL_1904 S YopX protein 0XUQJ Cluster_188856 V1002093 CLPL O ATP-dependent Clp protease ATP-binding subunit COG0542 Cluster_189701 V1002094 GATA map00970,map01100 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) COG0154 Cluster_682096 V1002095 OCAR_6878 map00281,map01110 C acyl-Coa dehydrogenase 0ZM68 Cluster_456449 V1002096 SRPF S NA 11IBX Cluster_227508 V1002097 MANA map00051,map00520,map01100,map01110 G mannose-6-phosphate isomerase COG1482 Cluster_501690 V1002098 MALA S maltodextrose utilization protein MalA COG5521 Cluster_421109 V1002099 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_548210 V1002100 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_664451 V1002101 S NA 12BEE Cluster_392563 V1002102 L C-5 cytosine-specific DNA methylase 0YDMD Cluster_192407 V1002105 NHAP P Na H antiporter COG0025 Cluster_631872 V1002106 map00230 S phosphorylase 11F11 Cluster_336241 V1002107 SP_0483 map02010 P ABC transporter COG1122 Cluster_591778 V1002108 S NA 0ZHU9 Cluster_740638 V1002109 PURS map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG1828 Cluster_378430 V1002110 S NA 0XPQF Cluster_368277 V1002111 YLME F alanine racemase domain protein COG0325 Cluster_591779 V1002112 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_525343 V1002114 V Vanz family COG4767 Cluster_598774 V1002115 K HTH_XRE 0XUC3 Cluster_197677 V1002117 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_827671 V1002118 RPMD map03010 J 50S ribosomal protein L30 COG1841 Cluster_195099 V1002119 PTSG map00010,map00500,map00520,map02060 G PTS system COG2190 Cluster_195960 V1002120 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_489010 V1002121 LYSA map00260,map00270,map00300,map00330,map00480,map01100,map01110,map01120,map01230 E diaminopimelate decarboxylase COG0019 Cluster_212479 V1002122 S NA 0ZMA4 Cluster_351714 V1002123 M n-acetylmuramoyl-l-alanine amidase 11R58 Cluster_199655 V1002127 S NA 0YA5W Cluster_199656 V1002129 LYSS map00970 J lysyL-tRNA synthetase COG2898 Cluster_273441 V1002131 TREC map00052,map00500,map01100 G trehalose-6-phosphate hydrolase (EC 3.2.1.93) COG0366 Cluster_595174 V1002133 ILVD map00290,map00770,map01100,map01110,map01210,map01230 E Dihydroxy-acid dehydratase COG0129 Cluster_272072 V1002134 MGTA P magnesium-translocating p-type atpase COG0474 Cluster_454509 V1002135 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0302 Cluster_475199 V1002136 FOLE map00790,map01100 H GTP cyclohydrolase i COG0302 Cluster_887097 V1002137 BMUL_0468 S ycii-related COG2350 Cluster_548211 V1002138 YJDF S Protein of unknown function (DUF2992) 11PXB Cluster_743860 V1002139 BL02849 S Baat aCyl-coa thioester hydrolase COG1073 Cluster_698454 V1002140 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_475200 V1002141 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_533712 V1002142 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_440481 V1002143 AROG map00400,map01100,map01110,map01230 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) COG0722 Cluster_363202 V1002144 S VTC domain protein 11IRS Cluster_605877 V1002145 S NA 0ZW6I Cluster_473071 V1002146 BMUL_0473 S ABC transporter, permease COG4120 Cluster_458355 V1002147 S abc transporter atp-binding protein COG1101 Cluster_205885 V1002148 NHAA map00680 P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) COG3004 Cluster_205886 V1002149 D ftsk spoIIIe COG1674 Cluster_525344 V1002150 SUFS map00450,map00730,map01100 E Cysteine desulfurase COG0520 Cluster_528182 V1002151 NIFU C SUF system FeS assembly protein, NifU family COG0822 Cluster_747302 V1002153 AGRA map02020 T response regulator COG3279 Cluster_319621 V1002154 COMD map02020 T Histidine kinase COG2972 Cluster_812146 V1002155 YYZM S protein, conserved in bacteria COG4481 Cluster_499138 V1002156 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_643820 V1002158 HUTG map00330,map00340,map01100 E formiminoglutamate hydrolase COG0010 Cluster_417531 V1002159 HUTH map00340,map01100 E Histidine ammonia-lyase COG2986 Cluster_209170 V1002160 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_353405 V1002161 SP_1914 S Cell wall-active antibiotics response protein (DUF2154) 11V5T Cluster_209171 V1002162 S NA 0YA5W Cluster_210271 V1002165 MALX map02010 G extracellular solute-binding protein family 1 COG2182 Cluster_605878 V1002167 MURE map00300,map00550,map01100 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_432531 V1002168 SP_1529 M Polysaccharide Biosynthesis Protein COG2244 Cluster_300515 V1002169 DLTA map00473,map05150 H Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) COG1020 Cluster_211362 V1002170 CDR P pyridine nucleotide-disulfide oxidoreductase COG0607 Cluster_277425 V1002171 USP S CHAP domain protein COG3942 Cluster_408415 V1002173 L 5'-3' exonuclease COG0749 Cluster_647837 V1002174 L Resolvase COG1961 Cluster_268090 V1002178 L Replication Protein COG5655 Cluster_213574 V1002181 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_396173 V1002185 YQEH S ribosome biogenesis GTPase YqeH COG1161 Cluster_581907 V1002186 YQEG V had superfamily (subfamily IIIa) phosphatase COG2179 Cluster_214766 V1002187 PEPX E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) 0XPUZ Cluster_496489 V1002188 RPSG map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) COG0049 Cluster_509240 V1002189 RPSL map03010 J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) COG0048 Cluster_270775 V1002190 SSTT E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) COG3633 Cluster_385454 V1002191 PERMEASE S permease COG0701 Cluster_602262 V1002192 YCGQ S transporter substrate-binding protein COG3689 Cluster_248790 V1002193 CORA P transporter COG0598 Cluster_215910 V1002194 map00860,map01100,map01110 S decarboxylase 11UPA Cluster_285607 V1002195 ECSB U (ABC) transporter COG4473 Cluster_850759 V1002196 ECSA V abc transporter atp-binding protein COG1131 Cluster_217074 V1002197 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_417532 V1002199 S Membrane COG4485 Cluster_378431 V1002200 map00564,map01100 I PAP2 Family COG0671 Cluster_423004 V1021801 M domain protein COG4932 Cluster_337798 V1021805 LPTB map02010 S ABC transporter COG1137 Cluster_562965 V1021806 S Protein of unknown function (DUF1573) 120RE Cluster_364937 V1021807 RV1337 S Rhomboid family COG0705 Cluster_325728 V1021808 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_647919 V1021810 YPJD S MazG nucleotide pyrophosphohydrolase COG1694 Cluster_157646 V1021817 M peptidase M23 0XQC5 Cluster_142650 V1021819 LIPA map00561,map01100 S Triacylglycerol lipase COG1075 Cluster_473122 V1021820 ARGR K Regulates arginine biosynthesis genes (By similarity) COG1438 Cluster_403188 V1021822 L Resolvase, N terminal domain COG1961 Cluster_284220 V1021825 N Cell surface protein 0XQ7Y Cluster_143345 V1021829 ZNTA P p-type atpase COG2217 Cluster_143346 V1021830 U, W Pfam:YadA COG5295 Cluster_620750 V1021831 E, G Membrane COG0697 Cluster_171002 V1021832 WECB map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_170172 V1021833 AMIB map00360 E amidohydrolase COG1473 Cluster_171808 V1021834 SSCG_04455 S Methyltransferase 0XSGP Cluster_530986 V1021835 S NA 0YXHR Cluster_325729 V1021836 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_772719 V1021837 S NA 11EM6 Cluster_613268 V1021838 S NA 11YJ3 Cluster_489069 V1021839 RLMH S Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) COG1576 Cluster_219435 V1021841 MANA map00051,map00520,map01100,map01110 G mannose-6-phosphate isomerase COG1482 Cluster_854694 V1021842 PNUC H nicotinamide mononucleotide transporter COG3201 Cluster_698512 V1021846 PGN_0051 S NA 0YP2S Cluster_792159 V1021847 S NA 0XNWW Cluster_368317 V1021850 YUGP S zinc metallopeptidase COG2738 Cluster_145580 V1021855 TPAU_0274 L transposase COG3547 Cluster_436505 V1021857 AZL_008490 L DNA methylase COG0863 Cluster_539529 V1021858 S NA 0YZDB Cluster_174365 V1021859 TELA P Resistance protein COG3853 Cluster_209201 V1021862 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E brancheD-chain amino acid aminotransferase COG0115 Cluster_242285 V1021867 RPOD map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_307655 V1021868 S NA 11EHP Cluster_222943 V1021869 M Glycosyl transferase, family 2 COG0463 Cluster_192443 V1021872 L site-specific recombinase, phage integrase family 11HGP Cluster_369974 V1021873 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_631962 V1021883 M efflux transporter, rnd family, mfp subunit COG0845 Cluster_151883 V1021884 M domain protein COG4932 Cluster_336281 V1021885 LMRA V ABC transporter, ATP-binding protein COG1132 Cluster_346976 V1021886 HEMG map00860,map01100,map01110 H protoporphyrinogen oxidase COG1232 Cluster_598853 V1021888 RPLN map03010 J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) COG0093 Cluster_737195 V1021889 RPSQ map03010 J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal COG0186 Cluster_605941 V1021891 FKPA O peptidylprolyl cis-trans isomerase COG0545 Cluster_188873 V1021892 RECQ map03018 L ATP-dependent DNA helicase RecQ COG0514 Cluster_217108 V1021894 LDH map00010,map00270,map00620,map00640,map01100,map01110,map01120 C lactate/malate dehydrogenase, alpha/beta C-terminal domain COG0039 Cluster_850830 V1021895 MT1293 map00350,map00362,map00627,map00642,map00903,map01120 I Acyl-transferase COG1835 Cluster_218222 V1021897 METN map02010 P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COG1135 Cluster_181021 V1021898 L Site-specific recombinase, phage integrase family 11F8N Cluster_228720 V1021900 TYRA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydrogenase COG0287 Cluster_345419 V1021903 S domain protein 1009W Cluster_707773 V1021906 RPSO map03010 J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) COG0184 Cluster_195974 V1021907 FBA map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01230 G fructose-bisphosphate aldolase COG0191 Cluster_430577 V1021908 EFP J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) COG0231 Cluster_517242 V1021909 S Thioesterase 11QVX Cluster_394344 V1021911 S Cytidylate kinase 0XP28 Cluster_158518 V1021912 S NA 0Y9QN Cluster_155969 V1021915 ILVC map00290,map00770,map01100,map01110,map01210,map01230 E Alpha-keto-beta-hydroxylacyl reductoisomerase COG0059 Cluster_605942 V1021917 S NA 0ZHU9 Cluster_292371 V1021918 MANY map00051,map00520,map01100,map02060 G PTS System COG3715 Cluster_183647 V1021921 PNTB map00760,map01100 C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) COG1282 Cluster_843164 V1021923 S NA 0ZHU9 Cluster_149443 V1021929 Y1701 map05133 U Inherit from COG: filamentous hemagglutinin family outer membrane protein COG3210 Cluster_162739 V1021930 S NA 0XPM9 Cluster_397952 V1021934 S NA 11KNZ Cluster_282846 V1021936 NOC K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) COG1475 Cluster_458405 V1021937 map00130 S nad(p)h dehydrogenase (quinone) COG2249 Cluster_158519 V1021940 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_838992 V1021945 MRDA map00550 M Penicillin-binding protein 2 COG0768 Cluster_470994 V1021946 MRED S Rod shape-determining protein MreD 1267M Cluster_318126 V1021950 S NA 12BX3 Cluster_494049 V1021953 STHE_0097 S doxx family COG2259 Cluster_313425 V1021954 COBM map00860,map01100 H precorrin-4 C(11)-methyltransferase COG2875 Cluster_276147 V1021955 SOJ D Chromosome Partitioning Protein COG1192 Cluster_486781 V1021958 SIGH K rna polymerase sigma factor COG1595 Cluster_539530 V1021960 S NA 0XXJW Cluster_509300 V1021961 S NA 124KR Cluster_151884 V1021962 UVRA map03420 L excinuclease ABC subunit A COG0178 Cluster_380175 V1021963 CICA E HAD-superfamily subfamily IB hydrolase COG0560 Cluster_151885 V1021968 GLNS map00970,map01100 J glutaminyL-tRNA synthetase COG0008 Cluster_284221 V1021970 C radical SAM domain protein COG0731 Cluster_780095 V1021972 S NA 0ZHU9 Cluster_668868 V1021975 ORF010 S Staphylococcal protein of unknown function (DUF960) 1265C Cluster_468888 V1021976 CCU S Protein of unknown function (DUF1643) COG4333 Cluster_181867 V1021977 MT0425 S secreted protein 10SG5 Cluster_152738 V1021980 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_578762 V1021981 S Conserved Protein COG1556 Cluster_291046 V1021982 BMUL_5818 C Iron-sulfur cluster binding protein COG1139 Cluster_701613 V1021983 YEAZ O Peptidase M22 Glycoprotease COG1214 Cluster_333242 V1021984 map00790,map01100 H Pterin binding enzyme COG0294 Cluster_501737 V1021985 FMT S decarboxylase family COG1611 Cluster_339282 V1021990 S NA 0YDZN Cluster_827723 V1021991 L Pfam:Transposase_11 0YB49 Cluster_277460 V1021993 P tonB-dependent Receptor 0XNN9 Cluster_545241 V1021994 S NA 0YIEB Cluster_788393 V1021996 PGN_0048 S NA 0YI97 Cluster_444557 V1021997 L Integrase 0YTFQ Cluster_156952 V1219801 SPSC map00362,map00363,map00520,map00626,map00650,map00903,map01100,map01110,map01120,map02020 M Polysaccharide biosynthesis protein COG0399 Cluster_534409 V1219802 LDB1085 S NA 0YWIA Cluster_326028 V1219803 map00230 S phosphorylase 11F11 Cluster_303666 V1219804 RSMI G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 Cluster_378831 V1219805 YABB map00340,map00350,map00624,map01120 L Methyltransferase COG4123 Cluster_53047 V1219806 COBN map00860,map01100 H cobaltochelatase, cobn subunit COG1429 Cluster_400000 V1219808 MT2477 S PemK-like protein 11VAX Cluster_467197 V1219809 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_65104 V1219810 FADD map00071,map01100,map03320,map04146,map04920 I Long-chain-fatty-acid--CoA ligase COG1022 Cluster_403569 V1219812 PDXP G hydrolase COG0647 Cluster_279065 V1219813 RRMJ J Hemolysin A COG1189 Cluster_497109 V1219814 FABT K Transcriptional regulator, MarR family 11N9R Cluster_225509 V1219815 FABH map00061,map01100 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) COG0332 Cluster_232431 V1219816 S AIPR protein 0ZFWF Cluster_203972 V1219818 GLGA map00500,map01100,map01110 G glycogen) synthase COG0438 Cluster_54534 V1219819 EMBC M Arabinosyltransferase 0XSQE Cluster_392957 V1219820 TILS D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) COG0037 Cluster_430964 V1219821 S phospholipase COG4667 Cluster_542998 V1219822 S Domain of unknown function (DUF1896) 0YBI2 Cluster_554762 V1219823 THIC map00730,map01100 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) COG0422 Cluster_738008 V1219828 ELAA S gCN5-related N-acetyltransferase COG2153 Cluster_104001 V1219829 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_711584 V1219830 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_67890 V1219831 YXCA I coA-substrate-specific enzyme activase COG3581 Cluster_120620 V1219833 S NA 0Z0R9 Cluster_554763 V1219834 LEBU_0481 L Transposase COG1943 Cluster_131124 V1219835 BCOA_0505 L transposase COG0675 Cluster_82122 V1219836 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_335050 V1219837 Q Methyltransferase Type COG0500 Cluster_458861 V1219838 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_61275 V1219840 TRAA L TrwC relaxase COG0507 Cluster_216131 V1219845 LIAG map02020 S Inherit from NOG: Membrane 0XV6C Cluster_114204 V1219846 S Iron transport-associated domain protein 0Y3IT Cluster_261674 V1219847 METN map02010 P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COG1135 Cluster_913203 V1219848 AARI_34870 L transposase of ISAar22, IS481 family COG2801 Cluster_124098 V1219849 GBRO_0040 L Transposase COG3464 Cluster_657043 V1219851 S NA 0XVGU Cluster_138242 V1219852 NATB C, P ABC transporter, permease COG1668 Cluster_114205 V1219853 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG1754 Cluster_384105 V1219854 PPM1 map00510,map01100 M dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) 0XQRC Cluster_171970 V1219855 LNT M Transfers the fatty acyl group on membrane lipoproteins (By similarity) COG0815 Cluster_254001 V1219857 STSB P Binding-protein-dependent transport systems, inner membrane component COG0601 Cluster_305173 V1219858 SCLAV_2693 P Binding-protein-dependent transport systems, inner membrane component 11V45 Cluster_237295 V1219859 CBPA O DnaJ domain protein COG2214 Cluster_421516 V1219861 CARD K Transcriptional regulator (CarD family COG1329 Cluster_339553 V1219862 ISPD map00900,map01100,map01110 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COG1211 Cluster_515154 V1219864 SP_1730 S Membrane COG3610 Cluster_171971 V1219865 HEMZ map00860,map01100,map01110 H coproporphyrinogen III oxidase COG0635 Cluster_228943 V1219867 AARI_34870 L transposase of ISAar22, IS481 family COG2801 Cluster_122156 V1219869 S NA 0ZX1V Cluster_499772 V1219870 S Domain of unknown function (DUF2088) COG3875 Cluster_59075 V1219871 S Rib/alpha-like repeat 10008 Cluster_216132 V1219872 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit delta' COG1466 Cluster_702263 V1219873 RES V Type III COG3587 Cluster_105808 V1219874 L ATP-dependent endonuclease of the OLD COG3593 Cluster_239884 V1219875 RBSC map02010 G Ribose transport system permease protein RbsC COG1172 Cluster_211612 V1219877 M Cell wall anchor domain protein 11PS2 Cluster_592616 V1219879 S Domain of unknown function (DUF3560) 100XC Cluster_294026 V1219882 K anti-repressor COG3645 Cluster_569978 V1219883 YAAT S psp1 domain protein COG1774 Cluster_324529 V1219884 S NA 0YFZU Cluster_357088 V1219885 YDFK S Membrane COG1811 Cluster_484989 V1219886 SGLY_0535 S phage protein 16PS0@proNOG Cluster_465118 V1219887 K NA 0YWD9 Cluster_542999 V1219888 COBC map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01230 H phosphatase COG0406 Cluster_345744 V1219889 TNP L transposase COG3316 Cluster_226630 V1219890 C alcohol dehydrogenase COG0604 Cluster_758489 V1219891 PGSA1 map00562,map00564,map01100,map04070 I Cdp-alcohol phosphatidyltransferase COG0558 Cluster_255207 V1219892 HTRB map00540,map01100 M lipid a biosynthesis lauroyl acyltransferase COG1560 Cluster_423375 V1219893 PIMA M Glycosyl transferase (Group 1 COG0438 Cluster_384106 V1219895 YQFA S hemolysin iii COG1272 Cluster_738011 V1219896 M (sortase) family COG3764 Cluster_285927 V1219897 CYDC map02010 P ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC COG1132 Cluster_563699 V1219900 S Pfam:DUF1696 11UJ8 Cluster_197894 V1219902 GRDB S Selenoprotein B, glycine betaine sarcosine D-proline reductase family 0XPCF Cluster_669758 V1219903 G Major Facilitator 0XPHU Cluster_517827 V1219904 map00440,map01110 M N-acetyltransferase COG1247 Cluster_140510 V1219905 SHC P drug resistance transporter, EmrB QacA subfamily 0XNN3 Cluster_342528 V1219906 TNP L transposase COG3316 Cluster_294027 V1219907 APHA J Aminoglycoside COG3231 Cluster_62086 V1219908 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_531629 V1219909 COBU map00860,map01100 H Adenosylcobinamide kinase COG2087 Cluster_318430 V1219910 S integral membrane protein 11MQQ Cluster_268392 V1219912 RBSA map02010 G ABC transporter COG1129 Cluster_156953 V1219917 S Inherit from NOG: peptidase inhibitor activity 0XX92 Cluster_62633 V1219918 LKTB3 V ABC transporter, ATP-binding protein COG2274 Cluster_687561 V1219919 BCOA_0505 L transposase COG0675 Cluster_252745 V1219920 TOPB L Dna topoisomerase COG0550 Cluster_324530 V1219923 S NA 12A8X Cluster_636891 V1219924 S Uncharacterized BCR, YitT family COG1284 COG1284 Cluster_102255 V1219925 YBIT S ABC transporter COG0488 Cluster_218465 V1219928 G Exopolysaccharide biosynthesis protein COG4632 Cluster_249050 V1219931 PFLX S radical SAM domain protein COG1313 Cluster_287334 V1219932 NADE map00760,map01100 H nh(3)-dependent nad( ) synthetase COG0171 Cluster_699183 V1219934 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_63462 V1219935 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_859531 V1219936 S NA 11WI9 Cluster_189024 V1219938 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG0582 Cluster_475731 V1219940 PDXS map00750 H Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) COG0214 Cluster_563700 V1219941 MT2684 L nudix hydrolase COG0494 Cluster_303667 V1219942 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_144217 V1219944 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_233699 V1219945 S Hydrid cluster protein-associated redox disulfide domain protein 123UM Cluster_358760 V1219946 S radical SAM domain protein 11FK0 Cluster_255208 V1219948 CORA P magnesium and cobalt transport protein CorA COG0598 Cluster_382333 V1219949 RIBD2 H bifunctional deaminase-reductase domain protein COG1985 Cluster_563701 V1219950 S Radical SAM superfamily COG0641 Cluster_599613 V1219951 AROQ map00400,map01100,map01110,map01230 E Catalyzes a trans-dehydration via an enolate intermediate (By similarity) COG0757 Cluster_196150 V1219952 AROB map00400,map01100,map01110,map01230 E 3-dehydroquinate synthase COG0337 Cluster_721532 V1219953 YAAK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) COG0718 Cluster_152048 V1219954 AARI_34710 L Transposase for insertion sequence 11IYJ Cluster_312253 V1219955 LGT M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 Cluster_318431 V1219956 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_454958 V1219960 LEPB map03060 U Signal peptidase i COG0681 Cluster_203973 V1219961 G Major Facilitator 0XPHU Cluster_515156 V1219962 K MarR family Transcriptional regulator 0Y4KW Cluster_509872 V1219965 ASP23 S alkaline shock protein COG1302 Cluster_276398 V1219966 SSCG_06117 S degv family COG1307 Cluster_94691 V1219967 THID map00730,map01100 H phosphomethylpyrimidine kinase COG0819 Cluster_360424 V1219968 SSCG_03030 map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_112765 V1219969 DACA map00550,map01100 M carboxypeptidase COG1686 Cluster_176131 V1219975 TRAA L TrwC relaxase COG0507 Cluster_322957 V1219976 LGT M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 Cluster_751512 V1219977 K Inherit from COG: Transcriptional regulator COG3655 Cluster_153654 V1219978 P Chloride channel COG0038 Cluster_800891 V1219979 BMUL_2943 G Major Facilitator Superfamily 0XNST Cluster_243882 V1219980 P Pfam:C4dic_mal_tran COG1275 Cluster_480351 V1219981 LYSR K LysR family (Transcriptional regulator COG0583 Cluster_543000 V1219982 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_507286 V1219984 ARGJ map00330,map01100,map01110,map01210,map01230 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) COG1364 Cluster_80971 V1219985 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_621535 V1219986 MT3093 E amino acid-binding act 0ZHQE Cluster_177789 V1219987 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_407063 V1219988 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_355399 V1219989 RSMG M Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) COG0357 Cluster_71825 V1219990 ACTP E sodium solute COG4147 Cluster_589251 V1219991 map02020,map03070 U Prokaryotic N-terminal methylation motif 0ZR0Y Cluster_442966 V1219994 S NA 11XN9 Cluster_705348 V1219995 S NA 0ZX1V Cluster_272379 V1219996 SP_1681 G ABC transporter (Permease COG0395 Cluster_313743 V1219998 CAFA map03018 J ribonuclease COG1530 Cluster_465119 V1219999 S NA 0ZS73 Cluster_292653 V1220000 DAPE map00300,map00330,map01100,map01110,map01120,map01210,map01230 E succinyl-diaminopimelate desuccinylase COG0624 Cluster_367012 V1220001 FMT S decarboxylase family COG1611 Cluster_489621 V1220002 C NADH dehydrogenase 12BDE Cluster_741431 V1220003 L Transposase 0ZX7U Cluster_256439 V1220004 MVAN_1091 L Integrase catalytic subunit COG2801 Cluster_661277 V1220005 MVAN_1090 L transposase, IS3 IS911 family protein 128FE Cluster_299463 V1220006 map02010 P Abc transporter COG1120 Cluster_68896 V1220007 L helicase domain protein COG0553 Cluster_147287 V1220008 S NA 0ZGFA Cluster_162046 V1220010 OCAR_7462 map00270,map00450,map01100,map01110,map01230 E Methionine synthase COG0620 Cluster_153655 V1220011 PRFC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) COG4108 Cluster_436945 V1220012 QCRC map00190,map01100 C cytochrome C COG2010 Cluster_412493 V1220013 CTAE map00190,map00910,map01100 C oxidase (Subunit III) COG1845 Cluster_430965 V1220014 AHPC O Peroxiredoxin COG0450 Cluster_252746 V1220015 COBL map00860,map01100 H Precorrin-6y C5,15-methyltransferase COG2242 Cluster_324531 V1220016 RV2073C I, Q short-chain dehydrogenase reductase COG1028 Cluster_250310 V1220017 LACC map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G tagatose-6-phosphate kinase COG1105 Cluster_284487 V1220018 S abc transporter permease protein 124X7 Cluster_268393 V1220019 ECFA2 map02010 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates COG1122 Cluster_319911 V1220020 THYX map00240,map00340,map00350,map00624,map00670,map01120 F Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) COG1351 Cluster_85914 V1220021 SPOIID D SpoIID LytB domain protein COG2385 Cluster_212696 V1220022 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily COG1368 Cluster_319912 V1220023 GLPQ map00564 C glycerophosphoryl diester phosphodiesterase COG4781 Cluster_545939 V1220024 GLPQ map00564 C glycerophosphoryl diester phosphodiesterase COG4781 Cluster_809136 V1220025 S Inherit from COG: conserved protein COG1434 Cluster_512454 V1220026 DTD J Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) COG1490 Cluster_851751 V1220027 S NA 0ZHU9 Cluster_268394 V1220029 S phospholipase COG4667 Cluster_142769 V1220030 S NA 125HN Cluster_423376 V1220032 S Phage-associated protein 11FS5 Cluster_196152 V1220034 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_144969 V1220035 DAPL map00300,map01100,map01110,map01230 H Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli (By similarity) COG0436 Cluster_310727 V1220039 HPRK T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) COG1493 Cluster_484990 V1220041 AMAA map00360 E amidohydrolase COG1473 Cluster_172878 V1220042 map00500,map01100,map04973 G alpha amylase, catalytic COG0366 Cluster_166881 V1220043 S NA 0ZS65 Cluster_102256 V1220045 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_425163 V1220046 UNG L uracil-dna glycosylase COG1573 Cluster_385871 V1220047 COBO map00860,map01100 H Cob-I-yrinic acid a,c-diamide adenosyltransferase COG2109 Cluster_247742 V1220048 COBB map00860,map01100 H Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) COG1797 Cluster_250311 V1220049 PAFB K Transcriptional regulator COG2378 Cluster_73856 V1220050 GBS0386 S domain protein 0XRRR Cluster_194420 V1220051 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_295438 V1220052 O DnaJ domain protein COG0484 Cluster_596098 V1220053 S domain protein 0Y8F3 Cluster_523153 V1220054 YTBE map00051,map00363,map00591,map00625,map00650,map01100,map01120 C reductase COG0656 Cluster_176132 V1220055 HISD map00340,map01100,map01110,map01230 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) COG0141 Cluster_419720 V1220056 YPRA L dEAD DEAH box helicase COG1205 Cluster_800892 V1220057 CSPA K Cold shock protein COG1278 Cluster_416142 V1220058 S dedA family COG0586 Cluster_452929 V1220059 NUDF map00230 F nudix hydrolase COG0494 Cluster_309283 V1220060 CSHA map03018 L ATP-dependent RNA helicase COG0513 Cluster_545940 V1220061 S Holin family 0YUUS Cluster_93747 V1220063 L transposase COG3666 Cluster_744744 V1220065 MJLS_1669 L transposase, IS3 IS911 family protein COG2963 Cluster_520375 V1220066 S DNA-binding helix-turn-helix protein 0ZJRR Cluster_277706 V1220069 S NA 12BX4 Cluster_385872 V1220072 COMEA L Competence protein COG1555 Cluster_124099 V1220076 MRCB map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_678600 V1220077 CAS2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) COG3512 Cluster_257725 V1220079 map05100 G s-layer domain protein 11IBF Cluster_202932 V1220081 U, W Pfam:YadA COG5295 Cluster_551899 V1220082 ATTT S acetyltransferase, (GNAT) family 11VF3 Cluster_76097 V1220083 S NA 0ZTYV Cluster_428992 V1220084 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_199890 V1220085 AMIDASE map00330,map00360,map00380,map00627,map00643,map01120 J Amidase COG0154 Cluster_484991 V1220087 GCVPB map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG1003 Cluster_528838 V1220088 DTD J Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) COG1490 Cluster_227765 V1220089 SCLAV_2537 J methyltransferase COG2890 Cluster_592617 V1220090 ARGR K Regulates arginine biosynthesis genes (By similarity) COG1438 Cluster_212697 V1220091 PRE S plasmid recombination enzyme 0XTDI Cluster_132646 V1220093 L Pfam:Transposase_11 0YB49 Cluster_196153 V1220094 HRCA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) COG1420 Cluster_115563 V1220095 M cell wall-binding protein COG2247 Cluster_741432 V1220099 MOAB2 H molybdenum cofactor biosynthesis protein COG0521 Cluster_540121 V1220101 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_392959 V1220102 MT1019 S saf domain-containing protein 122V5 Cluster_731461 V1220108 K Transcriptional Regulator AraC Family 0ZYR5 Cluster_210471 V1220112 YLOV S dak2 domain fusion protein ylov COG1461 Cluster_191665 V1220113 MEND map00130,map01100,map01110 H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) COG1165 Cluster_471487 V1220114 MENB map00130,map01100,map01110 H Naphthoate synthase COG0447 Cluster_394770 V1220117 ATPD map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG1394 Cluster_85538 V1220118 S Ragb susd domain-containing protein 0XPXH Cluster_410679 V1220120 D plasmid partition protein ParA COG1192 Cluster_644784 V1220122 ETFA map00910 C electron transfer flavoprotein alpha subunit COG2025 Cluster_275065 V1220123 LPXC map00061,map00540,map01100 M involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) COG0774 Cluster_168530 V1220126 S NA 11F3W Cluster_469338 V1220132 CCPA K Transcriptional regulator, LacI family COG1609 Cluster_279066 V1220134 REPA L Replication initiator protein A 0YDCP Cluster_592618 V1220136 map00540,map01100 S Phage-related protein 11PAV Cluster_102257 V1220137 S surface protein 11NE4 Cluster_341009 V1220138 E Peptidase family S51 11R1E Cluster_540122 V1220140 TCSR3 T regulatoR COG2197 Cluster_836128 V1220143 S Inherit from COG: oxidoreductase 0XPNK Cluster_259045 V1220144 M Sortase family COG3764 Cluster_122829 V1220146 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_82123 V1220147 PHOA map00521,map00627,map00790,map01100,map01110,map01120,map02020 P alkaline phosphatase COG1785 Cluster_371954 V1220150 COBD map00860,map01100 H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) COG1270 Cluster_112766 V1220151 SELB map00450,map00970 J Selenocysteine-specific translation elongation factor COG3276 Cluster_758491 V1220152 XSEB map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) 0ZZ01 Cluster_294028 V1220153 ISPA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_718203 V1220154 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_83395 V1220155 TRAA L TrwC relaxase COG0507 Cluster_589252 V1220159 DPRA L DNA protecting protein DprA COG0758 Cluster_392960 V1220160 S NA 11Y61 Cluster_371955 V1220161 BCELL_1025 L Transposase COG2801 Cluster_440952 V1220162 L Transposase 11X46 Cluster_300832 V1220163 BL00144 L Transposase COG2801 Cluster_380561 V1220164 L Transposase COG0675 Cluster_342530 V1220165 NLAXM map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_313744 V1220166 GLNQ E ABC transporter, ATP-binding protein COG1126 Cluster_385873 V1220167 SSCG_01435 E ABC transporter COG0765 Cluster_84713 V1220168 ELI_1307 M phage tail tape measure protein COG5283 Cluster_124753 V1220169 YJCE P Na H antiporter COG0025 Cluster_344118 V1220170 GLNQ map02010 E abc transporter atp-binding protein COG1126 Cluster_131894 V1220172 O phage portal protein HK97 family COG4695 Cluster_342531 V1220173 S Pfam:DUF322 0XUSX Cluster_454959 V1220174 S alkaline shock protein COG1302 Cluster_177790 V1220175 L DNA primase catalytic core domain protein COG0358 Cluster_86379 V1220178 SURB S G5 domain protein 0ZVV3 Cluster_515157 V1220179 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_692091 V1220180 S NA 0ZHU9 Cluster_327592 V1220181 SCLAV_1351 M Secreted protein COG0791 Cluster_557682 V1220182 CG2401 M Secreted protein COG0791 Cluster_436946 V1220183 ISPG map00900,map01100,map01110 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) COG0821 Cluster_636893 V1220184 ARSB P arsenicaL-resistance protein COG0798 Cluster_621536 V1220185 K Sugar-specific transcriptional regulator TrmB COG0640 Cluster_480352 V1220186 YDFG map00362,map01100,map01120 S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) COG2128 Cluster_344119 V1220189 S host cell surface-exposed lipoprotein 11S42 Cluster_86380 V1220190 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_446990 V1220191 ENTB Q Isochorismatase, hydrolase 11I3F Cluster_475732 V1220192 HEMN map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_832238 V1220198 S Suppressor of fused protein (SUFU) 11QEC Cluster_489622 V1220199 FUR K regulator Fur family COG0735 Cluster_166882 V1220202 FIC D cell filamentation protein COG2184 Cluster_338122 V1220204 L transposase 11GFI Cluster_487264 V1220205 HP1080 V restriction endonuclease COG1787 Cluster_531631 V1220206 S Membrane 12424 Cluster_196154 V1220207 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_489623 V1220208 V type I restriction modification DNA specificity domain COG0732 Cluster_201881 V1220209 HSDM-1 V Type I restriction-modification system, M subunit COG0286 Cluster_172879 V1220211 PRPE map00230 T Phosphatase COG4639 Cluster_758492 V1220213 NOCA_0571 L transposase COG2963 Cluster_247743 V1220214 TNPB L integrase catalytic COG2801 Cluster_327593 V1220215 S Inherit from COG: Alpha beta hydrolase COG0596 Cluster_389415 V1220216 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_665452 V1220218 S Protein of unknown function (DUF2516) 0XXPZ Cluster_333544 V1220219 S NA 12A0N Cluster_94692 V1220220 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_89975 V1220221 U TraG family COG3505 Cluster_335051 V1220222 IOLTB G ABC transporter COG1172 Cluster_371956 V1220223 IOLTC G ABC transporter COG1129 Cluster_90425 V1220224 M domain protein COG4932 Cluster_291296 V1220225 ZWF map00030,map00480,map01100,map01110,map01120 G glucose-6-phosphate 1-dehydrogenase COG0364 Cluster_871826 V1220226 ZWF map00030,map00480,map01100,map01110,map01120 G glucose-6-phosphate 1-dehydrogenase COG0364 Cluster_840000 V1220227 SDHA map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020,map05134 C succinate dehydrogenase, flavoprotein subunit COG1053 Cluster_326029 V1220228 SDHB map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120 C succinate dehydrogenase fumarate reductase iron-sulfur subunit COG0479 Cluster_396558 V1220230 RPSB map03010 J 30S ribosomal protein S2 COG0052 Cluster_382334 V1220231 map03022,map03420 L type iii restriction protein res subunit COG1061 Cluster_475733 V1220232 DPRE1 C FAD linked oxidase domain protein COG0277 Cluster_520376 V1220234 RV3789 S Membrane COG2246 Cluster_678601 V1220235 GLFT1 M Glycosyl transferase, family 2 COG1216 Cluster_289980 V1220236 SUFC O feS assembly ATPase SufC COG0396 Cluster_475734 V1220240 MT1505 map02010 V ABC transporter COG1131 Cluster_367013 V1220241 DARB map00061,map01100 I synthase III COG0332 Cluster_705349 V1220242 K Transcriptional regulator 1240D Cluster_151216 V1220243 G Major Facilitator superfamily 0XQFH Cluster_163685 V1220248 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_603180 V1220249 K Transcriptional regulator, ARAC family COG2207 Cluster_444946 V1220251 RHAT7 E, G Transporter COG0697 Cluster_269740 V1220252 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_405377 V1220253 XTHA map03410 L Exodeoxyribonuclease III COG0708 Cluster_384107 V1220254 LGT M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 Cluster_382335 V1220255 VEX2 V abc transporter atp-binding protein COG1136 Cluster_534411 V1220256 S HutP family 11NY2 Cluster_425164 V1220257 E amidohydrolase COG1473 Cluster_277707 V1220258 ABGT H Transporter COG2978 Cluster_178626 V1220259 MDLB map02010 V ABC transporter COG1132 Cluster_280370 V1220260 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG1754 Cluster_480353 V1220261 COBJ map00860,map01100 H Precorrin-3B C17-methyltransferase COG2243 Cluster_436947 V1220262 CLOSA_0730 V Hnh endonuclease COG1479 Cluster_277708 V1220263 O SPFH domain / Band 7 family COG0330 Cluster_520378 V1220264 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_391145 V1220265 MUTT L hydrolase COG0494 Cluster_168531 V1220266 PARE L DNA topoisomerase IV (Subunit B) COG0187 Cluster_554765 V1220267 SP_2057 I Acyl-transferase COG1835 Cluster_471488 V1220268 GYAR map00260,map00630,map00680,map01100,map01120,map01230 C D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding COG1052 Cluster_430966 V1220270 S NA 1243K Cluster_303668 V1220273 S Membrane COG2966 Cluster_260350 V1220277 LEUB map00290,map01100,map01110,map01210,map01230 E Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) COG0473 Cluster_135066 V1220278 ARGH map00250,map00330,map01100,map01110,map01230 E arginosuccinase COG0165 Cluster_97358 V1220279 YHGE S domain protein COG1511 Cluster_473598 V1220280 PAFA1 S proteasome 0XQPS Cluster_657045 V1220281 FTHC map00670,map01100 H 5-formyltetrahydrofolate cyclo-ligase COG0212 Cluster_223157 V1220282 GALU map00040,map00052,map00500,map00520,map01100,map01110 M UTP-glucose-1-phosphate uridylyltransferase COG1210 Cluster_195301 V1220283 FUSA2 J Translation elongation factor COG0480 Cluster_566896 V1220284 BMUL_0473 S ABC transporter, permease COG4120 Cluster_573188 V1220288 RV2239C S Protein of unknown function (DUF3052) 11N74 Cluster_463031 V1220290 RESA2 O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG0526 Cluster_540123 V1220292 PS333 L terminase (Small subunit) COG3728 Cluster_526074 V1220293 BL00759 L Phage terminase, large subunit COG1783 Cluster_98964 V1220294 SURB S G5 domain protein 0ZVV3 Cluster_217335 V1220295 M Glycosyl transferase family 2 COG0463 Cluster_569979 V1220296 AMRA M polysaccharide biosynthesis protein COG2244 Cluster_99487 V1220299 SUCA map00020,map00310,map00380,map01100,map01110,map01120 C 2-oxoglutarate dehydrogenase, E1 COG0567 Cluster_107053 V1220300 S NA 11NI8 Cluster_303669 V1220301 S integral membrane protein COG3182 Cluster_644785 V1220302 MENB map00130,map00360,map01100,map01110,map01120 H Naphthoate synthase COG0447 Cluster_599614 V1220304 S NA 0ZHU9 Cluster_262971 V1220305 YICL E, G Transporter COG0697 Cluster_201882 V1220310 ORFL L transposase COG2826 Cluster_154455 V1220311 ASPC map00250,map00290,map01100,map01110,map01210,map01230 E Aminotransferase COG0436 Cluster_375286 V1220312 BMUL_5568 S nerd domain protein 0XSNF Cluster_357089 V1220313 S NA 1241G Cluster_101139 V1220314 HSDM V HsdM N-terminal domain COG0286 Cluster_239885 V1220317 PRSA O Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) COG0760 Cluster_475735 V1220319 LEPB map03060 U Signal peptidase i COG0681 Cluster_781093 V1220322 HUNADC P transporter COG0471 Cluster_523154 V1220323 SDRA V type iii restriction COG1061 Cluster_175337 V1220324 BAES map02020 T Histidine kinase COG0642 Cluster_157819 V1220326 S Inherit from NOG: S-layer protein 0ZUVU Cluster_102800 V1220327 HELY L helicase COG4581 Cluster_509873 V1220329 PROTEASE map05120 O peptidase, U32 COG0826 Cluster_444947 V1220331 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_442967 V1220333 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG3848 Cluster_417950 V1220335 L Replication Protein 0YRQ2 Cluster_614098 V1220337 S Protein of unknown function (DUF1232) COG3339 Cluster_255209 V1220338 RIHC map00230,map00240,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_230093 V1220339 WBPC I Acyl-transferase COG1835 Cluster_614099 V1220340 GLPG S Rhomboid family COG0705 Cluster_454961 V1220341 FTHC map00670,map01100 H 5-formyltetrahydrofolate cyclo-ligase COG0212 Cluster_106415 V1220344 U, W Inherit from COG: domain protein COG5295 Cluster_844070 V1220345 DAGA E amino acid carrier protein COG1115 Cluster_178627 V1220346 PGM map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase (EC 5.4.2.2 COG0033 Cluster_335052 V1220347 S NA 0XQDK Cluster_687563 V1220348 YLXQ J ribosomal protein COG1358 Cluster_131895 V1220349 GCVPA map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG0403 Cluster_126099 V1220351 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_353724 V1220352 T response regulator 11GEV Cluster_534413 V1220353 BCRA map02010 V ABC transporter COG1131 Cluster_162887 V1220355 V Mate efflux family protein COG0534 Cluster_197895 V1220356 HOM map00260,map00270,map00300,map01100,map01110,map01120,map01230 E homoserine dehydrogenase COG0460 Cluster_731463 V1220357 LYSA map00300,map01100,map01110,map01120,map01230 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) COG0019 Cluster_380563 V1220359 V abc transporter atp-binding protein COG1131 Cluster_295439 V1220360 map02010 P ABC transporter COG1122 Cluster_477941 V1220361 map00630,map01100,map01110 S haloacid dehalogenase-like hydrolase COG0546 Cluster_108797 V1220362 MURG map00550,map01100,map04112 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) COG0707 Cluster_840001 V1220363 HELY L helicase COG4581 Cluster_178628 V1220364 PEPP map00310,map00780,map01100 E peptidase M24 COG0006 Cluster_644786 V1220365 SPOU J rrna methyltransferase COG0566 Cluster_614100 V1220366 RPLT map03010 J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) COG0292 Cluster_805096 V1220367 RPMI map03010 J 50S ribosomal protein L35 COG0291 Cluster_487265 V1220368 INFC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) COG0290 Cluster_129614 V1220369 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_440953 V1220371 S NA 180SD@proNOG Cluster_515158 V1220373 SP_0341 S UPF0371 protein COG4868 Cluster_138989 V1220375 V FtsX-like permease family 0ZW5X Cluster_793012 V1220376 PEPTIDASE E prolyl oligopeptidase COG1505 Cluster_166144 V1220377 PEPN_1 E Peptidase M1 membrane alanine aminopeptidase COG0308 Cluster_186482 V1220378 CAT1 map00281,map00620,map00626,map01110,map01120 C Transferase COG0427 Cluster_178629 V1220379 CARA map00240,map00250,map01100 F carbamoyl-phosphate synthetase glutamine chain COG0505 Cluster_754964 V1220380 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_312254 V1220381 S copper amine 121X1 Cluster_705351 V1220383 S Protein of unknown function (DUF1778) COG4453 Cluster_465120 V1220384 K Gcn5-related n-acetyltransferase COG0454 Cluster_520379 V1220385 RPLM map03010 J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) COG0102 Cluster_432971 V1220386 RPSI map03010 J 30S ribosomal protein S9 COG0103 Cluster_173713 V1220388 S surface protein 11NE4 Cluster_347326 V1220389 SCPA S Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) COG1354 Cluster_256440 V1220390 map00330,map00360,map00380,map00627,map00643,map01120 C Acetamidase formamidase COG2421 Cluster_396559 V1220391 TERY_3118 L Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) COG0553 Cluster_358761 V1220392 MCTB S wide pore channel activity 0XPWI Cluster_113505 V1220395 MEXF V AcrB AcrD family multidrug resistance protein COG0841 Cluster_113506 V1220397 RES V Type III COG3587 Cluster_563703 V1220398 SPXA_1 K transcriptional regulator, Spx COG1393 Cluster_430967 V1220399 S NA 0YEA2 Cluster_322958 V1220400 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_114206 V1220401 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_796955 V1220402 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_151217 V1220404 MEND map00130,map01100,map01110 H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) COG1165 Cluster_114881 V1220405 S NA 0ZTYV Cluster_384108 V1220406 S single-strand binding family protein 0XS6K Cluster_724881 V1220408 PSTS map02010,map02020,map05152 P Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) COG0226 Cluster_221979 V1220409 PSTC map02010 P phosphate abc transporter COG0573 Cluster_216133 V1220411 ECHA3 map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120 I Enoyl-CoA hydratase COG1024 Cluster_504705 V1220413 MERR2 K merR family transcriptional Regulator COG0789 Cluster_762256 V1220415 D cobyrinic Acid a,c-diamide synthase COG1192 Cluster_724882 V1220416 MRR V restriction COG1715 Cluster_851754 V1220417 MRR V restriction COG1715 Cluster_463032 V1220418 RES V Type III COG3587 Cluster_178630 V1220422 AFTD S coagulation factor 5 8 type domain-containing protein 0YR9E Cluster_116290 V1220423 TOPB L Dna topoisomerase COG0550 Cluster_116291 V1220424 S NA 0ZTYV Cluster_187320 V1220425 PEPP map00310,map00780,map01100 E peptidase M24 COG0006 Cluster_195302 V1220427 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_504706 V1220428 SHP S Cell surface heme-binding protein Shp 12069 Cluster_551900 V1220430 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_342532 V1220432 L Replication initiator protein A 0Y2JJ Cluster_233700 V1220433 PEPD map02020 O Peptidase s1 and s6 chymotrypsin hap COG0265 Cluster_119127 V1220437 V type II restriction enzyme, methylase subunit COG1002 Cluster_119128 V1220438 TOPB L Dna topoisomerase COG0550 Cluster_509874 V1220441 MSRB O reductase COG0229 Cluster_380564 V1220444 L Helicase COG1061 Cluster_367014 V1220445 SCLAV_2473 S NA 0XZ8Y Cluster_724883 V1220446 RNPA J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) 124YT Cluster_154456 V1220448 L DNA polymerase 0XRUF Cluster_632865 V1220450 S NA 0ZHU9 Cluster_122157 V1220451 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_657046 V1220452 S NA 0YW62 Cluster_389416 V1220453 S had-superfamily hydrolase, subfamily ia, variant COG1011 Cluster_167682 V1220454 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_122830 V1220455 AMIA map02010 E Oligopeptide-binding protein COG4166 Cluster_162047 V1220456 CSD1 L CRISPR-associated protein Csd1 family 0ZVNC Cluster_269741 V1220458 DEGV S degv family COG1307 Cluster_363560 V1220459 S NA 0ZF15 Cluster_543001 V1220461 S NA 1119B Cluster_296779 V1220462 SP_1461 map02010 E abc transporter permease protein 11RN5 Cluster_143469 V1220463 PRTC map05120 O collagenase COG0826 Cluster_220813 V1220464 PARC L DNA topoisomerase IV, subunit A COG0188 Cluster_549000 V1220467 COBK map00860,map01100 H reductase COG2099 Cluster_265680 V1220472 RSGA G May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) COG1162 Cluster_731464 V1220473 YQEY S gatB Yqey COG1610 Cluster_832239 V1220474 RPSU map03010 J 30S ribosomal protein S21 COG0828 Cluster_487266 V1220475 ARGR K Regulates arginine biosynthesis genes (By similarity) COG1438 Cluster_661278 V1220476 PARE L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_221980 V1220478 PABB map00790 E synthase component I COG0147 Cluster_721535 V1220480 CYSE map00270,map00920,map01100,map01120,map01230 E serine acetyltransferase COG1045 Cluster_241158 V1220481 CYSK map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_134270 V1220482 map03440 K Transcriptional regulator COG2865 Cluster_217336 V1220483 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_432972 V1220484 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_312255 V1220487 MSHB S Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) COG2120 Cluster_796957 V1220489 FDXA C Ferredoxin COG1146 Cluster_182086 V1220493 RV0485 K Transcriptional regulator COG1940 Cluster_640924 V1220494 MT3734 S Uncharacterized conserved protein (DUF2304) 122QX Cluster_357090 V1220495 MT3733 map00510,map01100 M Glycosyl transferase COG0463 Cluster_708455 V1220496 LSGF map00051 M glycosyltransferase COG0463 Cluster_859535 V1220497 MCBR K Transcriptional regulator 11WG2 Cluster_731465 V1220498 S Transglycosylase associated protein 12BJA Cluster_358762 V1220499 USPA1 T Universal stress protein COG0589 Cluster_189884 V1220500 MRCB map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_465121 V1220501 S single-strand binding family protein 0XS6K Cluster_531632 V1220508 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_128182 V1220511 SUN_0728 L transposase (IS4 family) protein 12CNV Cluster_665453 V1220513 TRXA O Thioredoxin COG0526 Cluster_387717 V1220515 L Replication Protein 0YRQ2 Cluster_487267 V1220518 YBAK S YbaK ebsC protein COG2606 Cluster_128894 V1220519 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_416143 V1220521 K Peptidase S24-like protein COG2932 Cluster_551901 V1220522 RV2239C S Protein of unknown function (DUF3052) 11N74 Cluster_246483 V1220524 TYPA T gtp-binding protein typa COG1217 Cluster_687564 V1220525 MJLS_1669 L transposase, IS3 IS911 family protein COG2963 Cluster_316856 V1220526 AARI_35290 L integrase catalytic COG2801 Cluster_400001 V1220527 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_596099 V1220528 O serine protease 11GRH Cluster_271052 V1220531 RES V Type III COG3587 Cluster_360425 V1220534 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_683129 V1220535 J Elongation factor Tu GTP binding domain COG0050 Cluster_131125 V1220536 E Peptidase, S9A B C family, catalytic domain protein COG1506 Cluster_714960 V1220537 K Transcriptional regulator 0XUC3 Cluster_648841 V1220538 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_863867 V1220541 S NA 12BS1 Cluster_368623 V1220542 YVDE J Glutamine amidotransferase COG2071 Cluster_322960 V1220543 N, O, T adapter protein MecA COG4862 Cluster_731467 V1220544 LDB1874 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_326031 V1220546 L SNF2 family DNA RNA helicase COG0553 Cluster_442969 V1220547 map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_131896 V1220548 RES V Type III COG3587 Cluster_281712 V1220549 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_298182 V1220552 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0470 Cluster_449010 V1220554 S Gp157 family 11ZXY Cluster_370338 V1220557 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_380565 V1220558 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_265681 V1220560 LYTR1 K TRANSCRIPTIONal COG1316 Cluster_617873 V1220561 S NA 0ZHU9 Cluster_166883 V1220566 K Inherit from firmNOG: Transcriptional regulator COG2865 Cluster_534414 V1220569 S NA 17HPJ@proNOG Cluster_520380 V1220570 S NA 0YVRK Cluster_243883 V1220571 S NA 11JF2 Cluster_391146 V1220572 GLNQ E abc transporter atp-binding protein COG1126 Cluster_614101 V1220574 O Pentapeptide repeat protein COG1357 Cluster_480354 V1220578 DCP E oligopeptidase A COG0339 Cluster_333545 V1220581 map05100 S repeat protein 11TEE Cluster_603181 V1220582 VAPC S Toxic component of a toxin-antitoxin (TA) module. A COG1487 Cluster_255210 V1220584 RLUC J pseudouridine synthase COG0564 Cluster_249051 V1220586 ARDC L antirestriction protein COG4227 Cluster_875913 V1220588 S NA 11HVF Cluster_231269 V1220589 LACC map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G tagatose-6-phosphate kinase COG1105 Cluster_499773 V1220593 SARZ K Transcriptional regulator 11TPH Cluster_492120 V1220594 K Transcriptional regulator COG1959 Cluster_348942 V1220595 EBA2484 L AtP-binding protein COG1484 Cluster_138990 V1220597 MBTB map01053 Q non-ribosomal peptide synthetase COG1020 Cluster_652930 V1220598 LACF map00052,map01100,map02060 G PTS System COG1447 Cluster_563704 V1220603 CDPW8_0140 S Protein of unknown function (DUF3644) 11FC8 Cluster_606789 V1220604 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_227766 V1220605 SPPA O, U Signal peptide peptidase, SppA COG0616 Cluster_140511 V1220606 N, U Inherit from COG: flagellar rod assembly protein muramidase flgj COG1705 Cluster_387718 V1220608 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_875914 V1220609 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_249052 V1220610 NANH map00520 E, M N-acetylneuraminate lyase COG0329 Cluster_269742 V1220611 S doxx family COG2259 Cluster_523155 V1220612 E solute binding transport lipoprotein COG0747 Cluster_410681 V1220613 SCLAV_2829 S Sec-C motif domain protein 100MK Cluster_644788 V1220614 BCELL_1025 L Transposase COG2801 Cluster_371958 V1220615 C SNARE associated Golgi COG0398 Cluster_432973 V1220616 PARC L DNA topoisomerase IV, subunit A COG0188 Cluster_636895 V1220617 map03440 K Transcriptional regulator COG2865 Cluster_327594 V1220618 map03440 K Transcriptional regulator COG2865 Cluster_198891 V1220620 YABE M domain protein COG3584 Cluster_142770 V1220621 M domain protein COG4932 Cluster_341011 V1220622 MDH map00620,map00710,map01100,map01120,map02020 C malate dehydrogenase (Oxaloacetate-decarboxylating) COG0281 Cluster_560749 V1220623 PKND E ABC transporter substrate-binding protein COG0834 Cluster_692093 V1220626 RPSO map03010 J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) COG0184 Cluster_257726 V1220627 S NA 12B83 Cluster_143470 V1220628 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_196155 V1220632 SCLAV_2561 O serine protease COG0265 Cluster_144970 V1220633 map03420,map03430 L helicase COG3973 Cluster_307869 V1220634 S Extracellular solute-binding protein, family 5 0XQUV Cluster_517828 V1220635 P Binding-protein-dependent transport systems, inner membrane component COG0601 Cluster_766221 V1220636 L transposase COG3328 Cluster_636896 V1220637 TNP3504J L Transposase COG2801 Cluster_579516 V1220638 NDVA2 V ABC transporter, ATP-binding protein COG1132 Cluster_273714 V1220639 V ABC transporter COG1132 Cluster_576412 V1220641 S Radical SAM superfamily COG0641 Cluster_502306 V1220642 AMIB map00360 E amidohydrolase COG1473 Cluster_569980 V1220643 RPSI map03010 J 30S ribosomal protein S9 COG0103 Cluster_442970 V1220644 S Conserved domain protein 0XZV4 Cluster_315328 V1220647 K, L domain protein COG0553 Cluster_708457 V1220648 S VRR-NUC domain protein 122HE Cluster_234893 V1220649 T Histidine kinase COG0642 Cluster_266990 V1220650 PRKC T Serine threonine protein kinase COG0515 Cluster_146514 V1220651 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_738014 V1220652 S helix-turn-helix domain protein 122WR Cluster_592620 V1220655 S NA 11M8V Cluster_644789 V1220657 ILVN map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E Acetolactate synthase small subunit COG0440 Cluster_257727 V1220658 ILVB map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E acetolactate synthase COG0028 Cluster_592621 V1220659 MANO S ManO family COG4687 Cluster_321389 V1220660 EBA2484 L AtP-binding protein COG1484 Cluster_844071 V1220662 RPMB map03010 J 50S ribosomal protein l28 COG0227 Cluster_292654 V1220664 RPFB L domain protein COG3583 Cluster_307870 V1220665 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_585941 V1220666 COAA map00770,map01100 H pantothenic acid kinase COG1072 Cluster_610453 V1220667 GAP map00010,map01100,map01110,map01120,map01230,map04066,map05010 G Glyceraldehyde-3-phosphate dehydrogenase COG0057 Cluster_373573 V1220668 DEDA S dedA family COG0586 Cluster_341012 V1220669 SCPA S Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) COG1354 Cluster_423377 V1220670 PNCA map00760,map01100 Q nicotinamidase COG1335 Cluster_579517 V1220672 YGAI S Methyl-accepting chemotaxis family protein COG4768 Cluster_921460 V1220673 S Protein of unknown function (DUF1294) COG3326 Cluster_367016 V1220674 YLME F alanine racemase domain protein COG0325 Cluster_368626 V1220675 NPTA P Sodium-dependent phosphate COG1283 Cluster_487268 V1220676 MDLB V abc transporter COG1132 Cluster_721536 V1220678 DNAJ1 O DnaJ domain protein COG2214 Cluster_361992 V1220679 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_322961 V1220681 V abc transporter permease protein 0ZW5X Cluster_785219 V1220682 K Transcriptional regulator 0XUP9 Cluster_150450 V1220683 L transposase COG0675 Cluster_360426 V1220685 MODB map02010 P molybdate abc transporter COG4149 Cluster_166145 V1220686 map02010 V ABC-2 type transporter COG0842 Cluster_150451 V1220687 S conjugation system ATPase, TraG family 0XSHU Cluster_385874 V1220688 MAF D MAF-like protein COG0424 Cluster_695905 V1220689 YBBK J Purine nucleoside phosphorylase COG1683 Cluster_475736 V1220690 CAS4 L crispr-associated protein Cas4 COG1468 Cluster_215000 V1220691 AROF map00400,map01100,map01110,map01230 E phospho-2-dehydro-3-deoxyheptonate aldolase COG2876 Cluster_419722 V1220693 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_389417 V1220694 SUN J Fmu (Sun) domain-containing protein COG0144 Cluster_371959 V1220696 S Domain of unknown function (DUF1837) 100DA Cluster_436949 V1220697 L helicase COG1204 Cluster_322962 V1220700 K Helix-turn-helix domain, rpiR family COG1737 Cluster_152885 V1220701 M Inherit from COG: YD repeat protein COG3209 Cluster_153656 V1220704 U, W Pfam:YadA COG5295 Cluster_162048 V1220706 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_444948 V1220707 RAIA J ribosomal subunit Interface protein COG1544 Cluster_540125 V1220711 KDPB map02020 P One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) COG2216 Cluster_421518 V1220712 L Transposase 11X46 Cluster_153657 V1220713 ADDB L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination COG3857 Cluster_255211 V1220714 ARGD map00300,map00330,map01100,map01110,map01120,map01210,map01230 E acetylornithine aminotransferase COG4992 Cluster_412494 V1220715 K transcriptional regulator COG1309 Cluster_384109 V1220716 S NA 11VAR Cluster_428994 V1220718 MSRA S methionine sulfoxide reductase A 0YJ5R Cluster_687565 V1220719 L UvrD REP helicase COG0210 Cluster_174521 V1220720 YBDL map00300,map01100,map01120,map01230 E Aminotransferase COG0436 Cluster_182989 V1220722 RECQ2 map03018 L ATP-dependent DNA helicase COG0514 Cluster_360427 V1220724 FTSK D cell division protein FtsK COG1674 Cluster_871828 V1220725 TRAI S Conjugative transposon protein TraI 0ZVHG Cluster_198892 V1220726 TRAJ S conjugative transposon 0XP5P Cluster_273715 V1220727 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_184681 V1220729 YPJC S YitT family COG1284 Cluster_545942 V1220730 PTRB map05142,map05143 E Oligopeptidase b COG1770 Cluster_365302 V1220731 MT0808 S Inherit from COG: deacetylase COG3233 Cluster_307871 V1220734 TRAA L TrwC relaxase COG0507 Cluster_276399 V1220736 ISPA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_171151 V1220738 M Cell wall binding repeat 2-containing protein COG2247 Cluster_421519 V1220739 YEBR T gaf domain protein COG1956 Cluster_294029 V1220741 S NA 11FM9 Cluster_157820 V1220742 TRAA map03440 L mobA MobL family protein COG0507 Cluster_268396 V1220744 METN map02010 P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COG1135 Cluster_321390 V1220746 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_157821 V1220747 U, W Pfam:YadA COG5295 Cluster_306560 V1220749 S alpha beta COG0596 Cluster_234894 V1220750 INSI L transposase COG2826 Cluster_158692 V1220751 MOD map00340,map00350,map00624,map01120 L DNA methylase COG2189 Cluster_582756 V1220752 S Prophage pi2 protein 37 11UE0 Cluster_276400 V1220754 S NA 0YWA6 Cluster_824688 V1220755 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_309284 V1220756 RPSB map03010 J 30S ribosomal protein S2 COG0052 Cluster_844072 V1220757 S NA 128M4 Cluster_348943 V1220762 S NA 0YM1X Cluster_161211 V1220766 AROP E amino acid COG1113 Cluster_160381 V1220767 TRSE U traE protein COG3451 Cluster_161212 V1220768 MMPL3 H MMPL domain protein COG2409 Cluster_161213 V1220769 FTSI map00550,map01100 M Stage V sporulation protein D COG0768 Cluster_163686 V1220770 S Filamentation induced by cAMP protein fic COG3177 Cluster_344120 V1220771 ARGB map00330,map01100,map01110,map01210,map01230 E nag kinase COG0548 Cluster_517829 V1220772 ARGJ map00330,map01100,map01110,map01210,map01230 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) COG1364 Cluster_847970 V1220773 MT1132 S NA 12B5W Cluster_407064 V1220774 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_162049 V1220779 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_224334 V1220782 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_585942 V1220787 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_321391 V1220788 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_408825 V1220789 S Membrane COG4330 Cluster_163687 V1220790 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_504707 V1220791 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_517830 V1220793 YXIE T Universal stress protein COG0589 Cluster_197896 V1220794 S Pfam:DUF2081 COG3472 Cluster_367017 V1220795 S Domain of unknown function (DUF1803) 0ZGP5 Cluster_163688 V1220796 GLSA map00250,map00330,map00471,map00910,map01100,map01120,map04724,map04727,map04964 E Glutaminase COG2066 Cluster_606791 V1220798 CLGR K Transcriptional regulator 122H2 Cluster_427095 V1220799 K, T Phage shock protein A COG1842 Cluster_407065 V1220800 S NA 11SFQ Cluster_526075 V1220801 SP_2122 S Major Facilitator 121QJ Cluster_242533 V1220802 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_504708 V1220803 DPNII V Type II restriction 0YTH4 Cluster_358763 V1220804 map04112 L DNA methylase n-4 n-6 domain protein COG0863 Cluster_589255 V1220805 MANO S Domain of unknown function (DUF956) COG4687 Cluster_205050 V1220806 S Membrane COG1434 Cluster_336574 V1220807 MT1025 S conserved transmembrane protein 12614 Cluster_781095 V1220808 XDHB map00230,map00633,map00680,map00720,map01100,map01120 C Dehydrogenase COG1319 Cluster_450982 V1220811 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_421520 V1220812 V abc transporter permease protein 0XQE2 Cluster_551902 V1220813 HIT F, G histidine triad (HIT) protein COG0537 Cluster_482667 V1220814 SCLAV_0395 V ABC transporter COG1132 Cluster_191667 V1220815 ZWF map00030,map00480,map01100,map01110,map01120 G glucose-6-phosphate 1-dehydrogenase COG0364 Cluster_599617 V1220816 PDXP G hydrolase COG0647 Cluster_363561 V1220817 SCLAV_1000 S TPR-repeat-containing protein 10GX4 Cluster_363562 V1220818 O sucraseferredoxin family COG4759 Cluster_629045 V1220819 S Secreted protein 11Z2N Cluster_523156 V1220821 S NA 0ZEDM Cluster_296780 V1220824 TELA P Resistance protein COG3853 Cluster_484993 V1220825 S Peptidase family M50 0Z3K7 Cluster_166146 V1220826 TERY_3118 L Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) COG0553 Cluster_482668 V1220827 LKTB3 V ABC transporter, ATP-binding protein COG2274 Cluster_531634 V1220828 CYCMA_0607 S transposase 11H93 Cluster_167683 V1220835 NDVA2 V ABC transporter, ATP-binding protein COG1132 Cluster_824691 V1220836 S inner membrane protein YbaN COG2832 Cluster_168532 V1220839 L type iii restriction protein res subunit COG3886 Cluster_728150 V1220840 PEPF E Oligoendopeptidase f COG1164 Cluster_333546 V1220841 Q Methyltransferase Type COG0500 Cluster_236095 V1220842 G Major Facilitator superfamily 0XP3M Cluster_242534 V1220843 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (alpha subunit) COG0587 Cluster_206128 V1220844 TAL map00010,map00030,map00500,map00520,map00710,map01051,map01100,map01110,map01120,map01230 G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) COG0176 Cluster_169461 V1220845 DPNA L helicase COG4646 Cluster_336575 V1220846 S NA 0YHMP Cluster_416144 V1220850 AHPC O alkyl hydroperoxide reductase COG0450 Cluster_456895 V1220851 AHPD S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) COG2128 Cluster_170328 V1220852 FADD map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG0318 Cluster_762257 V1220854 OORD map00020,map00720,map01100,map01120 C 4Fe-4S Ferredoxin, iron-sulfur binding domain protein COG1146 Cluster_170329 V1220855 ACEE map00010,map00020,map00620,map00650,map01100,map01110,map01120 C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) COG2609 Cluster_549001 V1220856 CLOLE_0796 L recT protein COG3723 Cluster_333547 V1220857 CLOLE_0797 S NA 11N1T Cluster_269743 V1220858 MT3308 S secreted protein 0XRRW Cluster_721537 V1220859 RHLE map03018 L Helicase COG0513 Cluster_170330 V1220860 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_515159 V1220862 map00010 G Cellulase (glycosyl hydrolase family 5) COG2723 Cluster_324533 V1220866 P cation diffusion facilitator family transporter COG0053 Cluster_171972 V1220868 FAS map00061,map01100 I fatty acid synthase COG4982 Cluster_517831 V1220869 OGT L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) COG0350 Cluster_427096 V1220870 YNIA map00564,map01100 G Fructosamine kinase COG3001 Cluster_350560 V1220871 S NA 0YBRU Cluster_824692 V1220873 CINA H competence damage-inducible protein COG1546 Cluster_172880 V1220874 TNPA L transposase COG4644 Cluster_636898 V1220875 MIHF S integration host factor 11UU9 Cluster_416145 V1220876 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG0194 Cluster_260351 V1220878 FBPC map02010 E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COG3842 Cluster_285928 V1220880 ENTE map01053 Q 2,3-dihydroxybenzoate-AMP ligase COG1021 Cluster_545943 V1220882 L ATP-dependent endonuclease of the OLD COG3593 Cluster_339554 V1220883 L Superfamily I DNA and RNA helicases-like COG0210 Cluster_502307 V1220887 RPLY map03010 J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) COG1825 Cluster_632866 V1220888 S alkaline shock protein COG1302 Cluster_718205 V1220890 map00350,map00362,map00627,map00642,map00903,map01120 S acetyltransferase, (GNAT) family COG0456 Cluster_805097 V1220891 S Nucleotidyltransferase domain 0ZNBK Cluster_174522 V1220892 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_517832 V1220893 S Inherit from NOG: LPXTG-motif cell wall anchor domain protein 0YEBJ Cluster_537314 V1220894 S ATP cone domain 0Y76S Cluster_674157 V1220895 XTH map03410 L Exodeoxyribonuclease III COG0708 Cluster_195303 V1220896 HEMH map00860,map01100,map01110 H Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) COG0276 Cluster_652933 V1220897 S Protein of unknown function (DUF2029) 0Y6D7 Cluster_563705 V1220902 TNPR L Resolvase COG1961 Cluster_407066 V1220903 L transposase COG4644 Cluster_276401 V1220904 BETA map00260,map01100 E Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) COG2303 Cluster_175339 V1220905 CAPA M Capsule synthesis protein COG2843 Cluster_816909 V1220907 RPSU map03010 J 30S ribosomal protein S21 122SW Cluster_875915 V1220908 MT2226 map00350,map00362,map00627,map00642,map00903,map01120 S Gcn5-related n-acetyltransferase COG0456 Cluster_285929 V1220909 S NA 11GVV Cluster_175340 V1220911 M domain protein COG4932 Cluster_176133 V1220914 DPNA L helicase COG4646 Cluster_176134 V1220918 S NA 12D1P Cluster_454962 V1220919 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0847 Cluster_419723 V1220922 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_446992 V1220923 S Terminase COG4626 Cluster_699184 V1220924 S NA 0YRYB Cluster_875916 V1220925 S NA 0XVZI Cluster_176955 V1220926 CYSN map00230,map00450,map00920,map01100,map01120 P may be the GTPase, regulating ATP sulfurylase activity (By similarity) COG2895 Cluster_262972 V1220927 CYDC map02010 V (ABC) transporter COG4987 Cluster_596100 V1220929 G Major Facilitator COG2807 Cluster_181155 V1220931 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_432974 V1220932 MT0057 S integral membrane protein COG5650 Cluster_199891 V1220936 ARGK E lAO AO transport system ATPase COG1703 Cluster_336576 V1220937 YBIW map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_276402 V1220938 S NA 0XQDK Cluster_540126 V1220939 NMB0459 S Filamentation induced by cAMP protein fic COG3177 Cluster_423379 V1220940 YCFI map02010 V abc transporter COG1132 Cluster_436950 V1220942 U relaxase mobilization nuclease domain protein COG3843 Cluster_836129 V1220943 TCSR3 T regulatoR COG2197 Cluster_238611 V1220944 T Histidine kinase COG4585 Cluster_183805 V1220945 AARI_34870 L transposase of ISAar22, IS481 family COG2801 Cluster_401791 V1220947 V restriction endonuclease 11GCV Cluster_512456 V1220948 DCM map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_621538 V1220949 RNY S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 Cluster_557683 V1220951 ACPS map00770 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) COG0736 Cluster_410682 V1220952 FAS map00061,map01100 I fatty acid synthase COG4982 Cluster_182087 V1220953 RUMAL_0348 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_427097 V1220954 PTH J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) COG0193 Cluster_449012 V1220957 YGAC J UPF0374 protein COG3557 Cluster_400002 V1220959 YLBB V abc transporter permease protein COG0577 Cluster_614102 V1220960 DNAQ map03420,map03430 L Uvrd rep helicase COG2176 Cluster_316857 V1220961 RC1_2786 L transposase COG5433 Cluster_781097 V1220963 YYAH map00620,map04011 E Glyoxalase Bleomycin resistance protein (Dioxygenase COG0346 Cluster_181156 V1220964 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_257728 V1220966 L Integrase COG0582 Cluster_543003 V1220967 S NA 0YIA5 Cluster_489624 V1220968 L helicase COG1204 Cluster_517833 V1220969 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_440955 V1220970 AATB map02010 E ABC transporter substrate-binding protein COG0834 Cluster_387719 V1220974 THYX map00240,map00670 F Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) COG1351 Cluster_599618 V1220975 DAPA map00300,map01100,map01110,map01120,map01230 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) COG0329 Cluster_329091 V1220976 XERD L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_603182 V1220977 NUDF map00230 F nudix hydrolase COG0494 Cluster_401792 V1220979 S O-methyltransferase-like protein 106VG Cluster_275066 V1220980 MSCS M mechanosensitive ion channel COG0668 Cluster_579518 V1220982 S NA 0XY0U Cluster_847972 V1220985 S NA 0XNWW Cluster_648843 V1220986 S Gcn5-related n-acetyltransferase 1221G Cluster_257729 V1220988 ACCBC map00061,map01100 I carboxylase COG4770 Cluster_184682 V1220990 S Relaxase mobilization nuclease 0Y9PG Cluster_321392 V1220991 DCP E oligopeptidase A COG0339 Cluster_477943 V1220993 ATPF map00190,map00195,map01100 C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) COG0711 Cluster_442971 V1220994 map00350,map00362,map00627,map00642,map00903,map01120 J -acetyltransferase COG1670 Cluster_184683 V1220995 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_184684 V1220996 FAS map00061,map00350,map00362,map00627,map00642,map00903,map01100,map01120 I synthase COG4982 Cluster_184685 V1220997 TRAA L TrwC relaxase COG0507 Cluster_492121 V1220999 LPD map00010,map00020,map00260,map00280,map00620,map01100,map01110,map01120 C dihydrolipoyl dehydrogenase COG1249 Cluster_766223 V1221002 S NA 0YIA5 Cluster_185562 V1221003 NDVA2 V ABC transporter, ATP-binding protein COG1132 Cluster_361993 V1221004 map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_820708 V1221005 S NA 11V4N Cluster_724886 V1221008 RPSO map03010 J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) COG0184 Cluster_692094 V1221009 ARSA map00600,map04142 P Arylsulfatase COG3119 Cluster_294030 V1221013 PSTA map02010 P phosphate abc transporter COG0581 Cluster_777355 V1221014 TRPG map00230,map00400,map00790,map00983,map01100,map01110,map01230 E anthranilate synthase COG0512 Cluster_449014 V1221015 HSDM V HsdM N-terminal domain COG0286 Cluster_678604 V1221016 S NA 0Y86B Cluster_264350 V1221018 RLUD J Pseudouridine synthase COG0564 Cluster_800894 V1221019 LSPA map03060 M, U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) COG0597 Cluster_621539 V1221020 MOAA map00790,map01100,map04122 H Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) COG2896 Cluster_370339 V1221021 FADD4 map00071,map01100,map03320,map04146,map04920 Q Amp-dependent synthetase and ligase COG0318 Cluster_377057 V1221023 S gCN5-related N-acetyltransferase 11U5D Cluster_189025 V1221024 PEPP E peptidase, M24 COG0006 Cluster_342533 V1221026 S NA 0XWFB Cluster_377058 V1221028 ELI_1297 O phage portal protein HK97 family COG4695 Cluster_189026 V1221029 S degv family COG1307 Cluster_492122 V1221030 FEOA P Ferrous iron transport protein A COG1918 Cluster_339555 V1221031 S NA 11NX4 Cluster_702264 V1221032 TRA L transposase COG2826 Cluster_189885 V1221034 TOCE_0081 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_412495 V1221036 FTSW D cell cycle protein COG0772 Cluster_573189 V1221043 TATD L Hydrolase, tatD family COG0084 Cluster_606792 V1221045 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_625321 V1221046 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_338124 V1221047 S PspC domain-containing protein 0Y3A6 Cluster_401793 V1221050 L phage plasmid primase, p4 family COG3378 Cluster_674158 V1221051 S NA 11QFB Cluster_432975 V1221052 TNPB L transposase COG0675 Cluster_410683 V1221054 S NA 0Y84K Cluster_669760 V1221057 YRDD L Dna topoisomerase COG0551 Cluster_434892 V1221060 S Inherit from COG: Pfam:DUF567 COG4894 Cluster_272380 V1221063 YFMR S Abc transporter COG0488 Cluster_327595 V1221064 SUCA map00020,map00310,map00380,map01100,map01110,map01120 C 2-oxoglutarate dehydrogenase, E1 COG0567 Cluster_423380 V1221065 FATD map02010 P permease protein COG4606 Cluster_573190 V1221067 MT2231 K transcriptional regulatory protein 11UQP Cluster_465122 V1221068 PKNL T Serine Threonine protein kinase COG2815 Cluster_194421 V1221069 PFLB map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_194422 V1221070 S NA 11NI8 Cluster_194423 V1221071 SURB S G5 domain protein 0ZVV3 Cluster_754966 V1221073 YSDC map00500,map01100 E Peptidase m42 family protein COG1363 Cluster_194424 V1221074 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_400003 V1221075 TMK map00240,map01100 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) COG0125 Cluster_592622 V1221078 RPSL map03010 J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) COG0048 Cluster_195304 V1221080 V Type I restriction-modification system R subunit COG4096 Cluster_398278 V1221081 S Methyltransferase 11PHP Cluster_363563 V1221082 SPD S Prophage Lp1 protein 65 0XSDQ Cluster_629046 V1221085 BL01323 M Cell wall binding repeat 2-containing protein 0ZKZU Cluster_292655 V1221086 M polysaccharide biosynthesis protein COG2244 Cluster_382336 V1221088 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_195305 V1221089 TRAA L TrwC relaxase COG0507 Cluster_492123 V1221090 LACD map00052,map01100 G Aldolase COG3684 Cluster_385875 V1221091 HRRA T regulatoR COG2197 Cluster_632867 V1221092 HRRS T Histidine kinase 0XNMH Cluster_268397 V1221094 DAPF map00300,map01100,map01110,map01120,map01230 E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) COG0253 Cluster_394771 V1221095 RPSE map03010 J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) COG0098 Cluster_824697 V1221096 RPMD map03010 J 50S ribosomal protein L30 COG1841 Cluster_836131 V1221097 RPLO map03010 J Binds to the 23S rRNA (By similarity) COG0200 Cluster_711589 V1221100 SCLAV_1045 S Membrane COG3346 Cluster_196156 V1221101 S domain protein 0YF83 Cluster_275067 V1221102 S NA 11MTE Cluster_467199 V1221103 DPS P ferritin dps family protein COG0783 Cluster_262973 V1221105 MODA map02010 P ABC transporter, periplasmic molybdate-binding protein COG0725 Cluster_276403 V1221108 S Cutinase 0YHDW Cluster_196967 V1221119 UUP S Abc transporter COG0488 Cluster_444949 V1221120 V Restriction modification system DNA specificity COG0732 Cluster_446993 V1221122 ELI_3039 K RNA Polymerase 1261F Cluster_339556 V1221123 map00230 Q RelA SpoT domain protein COG2357 Cluster_389418 V1221124 K NA 0Z0MV Cluster_200890 V1221126 L Integrase COG0582 Cluster_648845 V1221130 PPA map00190 C Inorganic pyrophosphatase COG0221 Cluster_563706 V1221133 MT3543 S NA 11ISP Cluster_502308 V1221134 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_410684 V1221135 SRTA M (sortase) family COG3764 Cluster_520382 V1221136 MCBR K Transcriptional regulator 11WG2 Cluster_198893 V1221137 SBCC3 S Cytosolic protein COG4913 Cluster_198894 V1221139 TRBE map03070 U conjugal transfer ATPase COG3451 Cluster_421521 V1221141 RNMV L Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) COG1658 Cluster_360428 V1221142 SGLY_1036 V (ABC) transporter COG1136 Cluster_199892 V1221143 MUTY map03410 L a g-specific adenine glycosylase COG1194 Cluster_257730 V1221144 BCGIA V Type II restriction modification enzyme methyltransferase COG0286 Cluster_820709 V1221146 S NA 0YVZD Cluster_456896 V1221149 ANSA map00250,map00460,map00910,map01100,map01110 E L-asparaginase COG0252 Cluster_458862 V1221150 S secreted protein 0Y4BT Cluster_789218 V1221151 WANG_1499 S Transposase 11N3I Cluster_444950 V1221155 BMUL_5568 S nerd domain protein 0XSNF Cluster_785222 V1221156 PUCB map00230,map01100,map01120 O 4-diphosphocytidyl-2c-methyl-d-erythritol synthase COG2068 Cluster_458863 V1221159 S NA 0ZHU9 Cluster_220814 V1221162 PCKA map00010,map00020,map00620,map00710,map01100,map01110,map01120 C Phosphoenolpyruvate Carboxylase COG1866 Cluster_201883 V1221163 CAP5F map00051,map00363,map00521,map00523,map00591,map00625,map00650,map01100,map01110,map01120 G, M epimerase dehydratase COG1898 Cluster_201884 V1221164 S Cutinase 0YUSA Cluster_377059 V1221165 G Major Facilitator superfamily 0XQFH Cluster_751514 V1221166 S ABC transporter, ATPase COG3044 Cluster_669761 V1221167 S Protein of unknown function (DUF2580) COG4842 Cluster_705355 V1221168 BCAV_3206 map05152 S Proteins of 100 residues with WXG COG4842 Cluster_652934 V1221170 S rRNA biogenesis protein Rrp5 0XUK3 Cluster_702265 V1221172 CLCAR_2470 G aldose 1-epimerase COG2017 Cluster_355400 V1221173 YWQD M Capsular exopolysaccharide family COG0489 Cluster_734686 V1221174 G, M Capsular polysaccharide biosynthesis protein COG4464 Cluster_606794 V1221175 RBPA S NA 11U3N Cluster_348944 V1221176 SUFC O feS assembly ATPase SufC COG0396 Cluster_579519 V1221178 S Toxic component of a toxin-antitoxin (TA) module. A 1274P Cluster_576413 V1221179 MT0235 map00051 M glycosyl transferase group 1 COG0438 Cluster_259047 V1221181 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_398279 V1221182 LIVK map02010 E Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein COG0683 Cluster_617875 V1221183 MUTT1 L NUDIX hydrolase COG0494 Cluster_250312 V1221186 RRGB M Lpxtg-motif cell wall anchor domain protein 0XSEP Cluster_238612 V1221188 S NA 11NGH Cluster_330490 V1221190 S NA 0ZMX8 Cluster_800895 V1221192 S NA 17D58@proNOG Cluster_339557 V1221196 S Cell surface protein 0ZXQA Cluster_477945 V1221197 QUEF map00790,map01100 S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) COG0780 Cluster_206129 V1221198 V Type III COG3587 Cluster_206130 V1221199 LHR L helicase COG1201 Cluster_309285 V1221201 L site-specific recombinase, phage integrase family 0ZQ44 Cluster_695908 V1221203 YJGR S ATP-binding protein COG0433 Cluster_549002 V1221205 S NA 0YWKD Cluster_206131 V1221206 YBBC V conserved protein UCP016719 COG3876 Cluster_206132 V1221207 ACTP P p-type atpase COG2217 Cluster_440956 V1221208 YUTD S transcriptional regulator COG4470 Cluster_412496 V1221209 map00230 Q RelA SpoT domain protein COG2357 Cluster_579520 V1221210 HSLR J Heat shock protein COG1188 Cluster_442972 V1221211 BL01877 K Transcriptional regulator COG1309 Cluster_458864 V1221212 GLFT M Transferase COG1216 Cluster_632868 V1221213 SULP P sulfate transporter COG0659 Cluster_385876 V1221214 THIE map00730,map01100 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) COG0352 Cluster_657049 V1221217 FTSL D Essential cell division protein (By similarity) COG4839 Cluster_669762 V1221218 BL02952 S Membrane COG1434 Cluster_683133 V1221219 LMRA V ABC transporter COG1132 Cluster_299464 V1221220 DAPB map00300,map01100,map01110,map01120,map01230 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) COG0289 Cluster_427098 V1221222 PSTS map02010,map02020,map05152 P phosphate COG0226 Cluster_582758 V1221224 S NA 183FK@proNOG Cluster_762260 V1221226 YYZM S protein, conserved in bacteria COG4481 Cluster_480356 V1221229 V HNH endonuclease COG1403 Cluster_543004 V1221230 SERB1 E HAD-superfamily subfamily IB hydrolase COG0560 Cluster_469340 V1221231 S -acetyltransferase 122ZA Cluster_718208 V1221232 YEIH S Membrane COG2855 Cluster_257731 V1221233 PCCB I carboxylase, beta COG4799 Cluster_606795 V1221239 DIVIC D Septum formation initiator COG2919 Cluster_307872 V1221241 E Sodium:solute symporter family COG0591 Cluster_339558 V1221242 S NA 0YYC5 Cluster_210472 V1221243 S (LipO)protein 0XSYT Cluster_579521 V1221244 TMK map00240,map01100 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) COG0125 Cluster_264351 V1221246 BMUL_3652 V Abortive infection bacteriophage resistance protein COG4823 Cluster_210473 V1221247 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_661280 V1221250 TRXA2 O Thioredoxin COG0526 Cluster_871829 V1221251 COAD map00770,map01100 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) COG0669 Cluster_416146 V1221252 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_728151 V1221253 RECG map03440 L ATP-dependent DNA helicase RecG COG1200 Cluster_336577 V1221254 KDPE map02020 T Response regulator receiver domain protein COG0745 Cluster_321393 V1221256 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_796959 V1221257 NUDF map00230 F nudix hydrolase COG0494 Cluster_210474 V1221259 PGN_0946 S Membrane COG1033 Cluster_449015 V1221261 T HPP family COG3448 Cluster_610454 V1221262 S NA 0YX7F Cluster_211615 V1221263 CAT1 map00281,map00620,map00626,map01110,map01120 C Transferase COG0427 Cluster_211616 V1221264 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_589257 V1221265 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_449016 V1221266 NRDI F Probably involved in ribonucleotide reductase function (By similarity) COG1780 Cluster_365303 V1221267 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_212698 V1221269 S fad dependent oxidoreductase COG2509 Cluster_469341 V1221271 YBBK J Purine nucleoside phosphorylase COG1683 Cluster_213818 V1221276 S NA 0YH2T Cluster_215001 V1221279 S NA 11FSG Cluster_315329 V1221281 TRMB C Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_489626 V1221285 P phosphonate ABC transporter substrate-binding protein COG3221 Cluster_254003 V1221286 B565_1256 S NA 11JBM Cluster_298183 V1221287 E Extracellular solute-binding protein, family 5 COG0747 Cluster_904895 V1221289 MSRB O reductase COG0229 Cluster_789219 V1221290 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_450983 V1221291 RV2876 S Protein of unknown function (DUF2631) 0Y36A Cluster_324535 V1221293 TELA P Resistance protein COG3853 Cluster_661281 V1221294 E amidohydrolase COG1473 Cluster_705356 V1221295 E amidohydrolase COG1473 Cluster_523158 V1221296 YJEE S protein family UPF0079, ATPase COG0802 Cluster_215002 V1221299 map00500,map01100 N Alpha-L-fucosidase 0XPGV Cluster_603183 V1221300 RPLL map03010 J Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) COG0222 Cluster_809140 V1221302 K Transcriptional regulator COG1476 Cluster_517834 V1221303 S NA 12D5B Cluster_216134 V1221304 U, W Pfam:YadA COG5295 Cluster_216135 V1221305 CSP1 M LGFP repeat COG5479 Cluster_566901 V1221307 map02010 V (ABC) transporter COG1131 Cluster_216136 V1221309 S NA 0Y940 Cluster_728152 V1221312 S YGGT family COG0762 Cluster_793016 V1221317 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_353725 V1221318 RSME S Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) COG1385 Cluster_494606 V1221319 S NA 11QS8 Cluster_509875 V1221320 S NA 100BM Cluster_218467 V1221321 SALY V ABC transporter COG0577 Cluster_800898 V1221322 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins COG0706 Cluster_436951 V1221323 RSMG M Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) COG0357 Cluster_781100 V1221324 REPA S Phage replisome organizer 0YDCP Cluster_741436 V1221325 S Transglycosylase-associated protein 125P9 Cluster_219624 V1221327 S YbbR-like protein 11RE7 Cluster_219625 V1221329 M Inherit from NOG: Polymorphic outer membrane protein 11KKP Cluster_754967 V1221331 S Plasmid pRiA4b ORF-3 family protein 1026Y Cluster_255212 V1221332 ATP2C1 P p-type ATPase COG0474 Cluster_800899 V1221336 GUFA P Mediates zinc uptake. May also transport other divalent cations (By similarity) COG0428 Cluster_219626 V1221337 KDPD map02020 T Osmosensitive K channel His kinase sensor COG2205 Cluster_507287 V1221338 S septicolysin 11TVT Cluster_509876 V1221339 MT0235 map00051 M glycosyl transferase group 1 COG0438 Cluster_339559 V1221340 YFIH S Multi-copper polyphenol oxidoreductase laccase COG1496 Cluster_326032 V1221342 PHOA map00521,map00627,map00790,map01100,map01110,map01120,map02020 P alkaline phosphatase COG1785 Cluster_226631 V1221343 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase ii COG0046 Cluster_292657 V1221344 ISPE map00900,map01100,map01110 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COG1947 Cluster_305174 V1221345 CDR P pyridine nucleotide-disulfide oxidoreductase COG0607 Cluster_614103 V1221346 S NA 0ZHU9 Cluster_465123 V1221347 DINF V Mate efflux family protein COG0534 Cluster_517835 V1221348 NRNA J phosphoesterase RecJ domain protein COG0618 Cluster_220815 V1221349 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_537316 V1221350 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_473599 V1221351 PPNK map00760,map01100 G Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) COG0061 Cluster_766227 V1221354 BDP_1102 V ABC transporter COG1136 Cluster_324536 V1221355 YLBB V abc transporter permease protein COG0577 Cluster_310728 V1221356 FABG3 map00140,map01100 S Short-chain dehydrogenase reductase Sdr COG1028 Cluster_625322 V1221358 ISCA O iron--sulfur cluster insertion protein erpA COG0316 Cluster_492124 V1221359 S Peptidase, S41 11XDZ Cluster_520383 V1221360 L transposase, IS605 OrfB COG0675 Cluster_243884 V1221364 P peroxidase COG2837 Cluster_223159 V1221366 PHTE S Pneumococcal histidine triad protein E 0Y9TQ Cluster_403570 V1221368 Y3395 S exported protein 11NNA Cluster_473600 V1221369 M Glycosyl transferase (Group 1 11H1P Cluster_489627 V1221370 S NA 0ZWIA Cluster_279067 V1221371 OXLT G Major Facilitator 0XQUK Cluster_288694 V1221372 map02010 P Transporter Permease Protein COG1178 Cluster_751515 V1221373 ERUM3880 S phage protein COG5410 Cluster_471489 V1221374 S NA 0Y208 Cluster_554766 V1221375 S helix-turn-helix domain protein 122WR Cluster_469342 V1221376 S NA 0ZA8M Cluster_644791 V1221382 S NA 123I8 Cluster_721539 V1221384 MPTA S Membrane 0XT70 Cluster_385877 V1221385 L Pfam:Transposase_11 0ZVJY Cluster_585943 V1221388 FAS map00061,map01100 I fatty acid synthase COG4982 Cluster_294031 V1221389 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_560750 V1221390 SSDA map00250,map00350,map00650,map01100,map01120 C Dehydrogenase COG1012 Cluster_432976 V1221391 NAGD map00627,map01120 G had-superfamily hydrolase, subfamily iia COG0647 Cluster_268398 V1221395 DPRE1 C FAD linked oxidase domain protein COG0277 Cluster_777356 V1221397 TRA L transposase COG2826 Cluster_350561 V1221398 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_227767 V1221401 ARGG map00250,map00330,map01100,map01110,map01230 E Citrulline--aspartate ligase COG0137 Cluster_824700 V1221406 S Protein of unknown function (DUF3042) 0Y0YB Cluster_347328 V1221407 HUNADC P transporter COG0471 Cluster_227768 V1221409 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_724887 V1221414 D, J addiction module toxin, RelE StbE family COG2026 Cluster_741438 V1221415 S toxin-antitoxin system, antitoxin component, ribbon-helix-helix 121PE Cluster_557684 V1221420 DCD map00240,map01100 F deoxycytidine triphosphate deaminase COG0717 Cluster_526076 V1221422 S NA 0ZEZ0 Cluster_360429 V1221424 EMBC M Arabinosyltransferase 0XSQE Cluster_789221 V1221425 AFTA M Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases 0Z57H Cluster_230094 V1221427 TRAG S conjugation system ATPase, TraG family 0XSHU Cluster_230095 V1221428 map01053 Q non-ribosomal peptide synthetase COG1020 Cluster_266991 V1221429 PARE L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_363565 V1221430 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_231271 V1221431 S Tape measure protein COG5281 Cluster_276404 V1221432 YITL S S1 RNA binding domain protein COG2996 Cluster_809142 V1221433 S NA 0Z6X2 Cluster_573191 V1221434 MT3438 K Transcriptional regulator COG0789 Cluster_289982 V1221436 MMPL3 H MMPL domain protein COG2409 Cluster_497113 V1221438 SP_1785 S Protein of unknown function (DUF3013) 1289G Cluster_345745 V1221439 TNP L transposase COG3316 Cluster_504710 V1221441 AFTD S coagulation factor 5 8 type domain-containing protein 0YR9E Cluster_566902 V1221442 LPPL S prolipoprotein LppL 0Z2Q4 Cluster_438980 V1221443 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) COG0167 Cluster_391147 V1221445 SCLAV_3539 G phosphoglycerate mutase COG0406 Cluster_840007 V1221446 HEML map00860,map01100,map01110 H Glutamate-1-semialdehyde aminotransferase COG0001 Cluster_232432 V1221447 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_232433 V1221448 S NA 101UU Cluster_754969 V1221449 S Nucleotidyl transferase of unknown function (DUF1814) 0XP6B Cluster_504711 V1221453 SCLAV_0509 S Cytochrome c oxidase caa3-type, assembly factor ctag-related protein COG3336 Cluster_632869 V1221454 map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_318433 V1221455 AFER_0154 L transposase IS3 IS911 family protein COG2801 Cluster_232435 V1221457 L Integrase 0YTFQ Cluster_260352 V1221458 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_440958 V1221459 ELI_3039 K RNA Polymerase 1261F Cluster_430969 V1221461 S Frg domain protein 0ZXCB Cluster_233701 V1221462 PPC map00620,map00680,map00710,map00720,map01100,map01120 C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) COG2352 Cluster_758496 V1221463 C, O Glutaredoxin-like domain (DUF836) COG0526 Cluster_450984 V1221464 SERB1 E HAD-superfamily subfamily IB hydrolase COG0560 Cluster_307873 V1221465 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_847975 V1221466 LEPB map03060 U Signal peptidase i COG0681 Cluster_234895 V1221468 M cell wall-binding protein COG2247 Cluster_234896 V1221469 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_728153 V1221470 YYAT map00350,map00362,map00627,map00642,map00903,map01120 Q acetyltransferase 121PI Cluster_625324 V1221472 SCLAV_0069 S Membrane COG2311 Cluster_758497 V1221473 RPMB map03010 J 50s ribosomal protein l28 COG0227 Cluster_851758 V1221474 RPMG map03010 J 50S ribosomal protein L33 COG0267 Cluster_405380 V1221475 COMF map00230,map00250,map01100,map01110 S Competence protein COG1040 Cluster_423381 V1221479 GPSA map00564 C NADPH-dependent glycerol-3-phosphate dehydrogenase COG0240 Cluster_711591 V1221480 MUTT1 L NUDIX hydrolase COG0494 Cluster_291297 V1221482 MURE map00300,map00550 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_339560 V1221485 S Abi-like protein 11WV5 Cluster_329092 V1221486 NMB0459 S Filamentation induced by cAMP protein fic COG3177 Cluster_820711 V1221487 MAA map00350,map00362,map00627,map00642,map00903,map01120 S O-acetyltransferase COG0110 Cluster_480357 V1221488 L Transposase, IS605 OrfB family 0XT7Q Cluster_610456 V1221490 S NA 0XXFR Cluster_296781 V1221491 SCLAV_2565 map00620 L Beta-lactamase domain protein COG0491 Cluster_467200 V1221493 ASP23 S alkaline shock protein COG1302 Cluster_614104 V1221494 ARSC P Transcriptional regulator, Spx MgsR family COG1393 Cluster_705357 V1221496 RPSQ map03010 J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal COG0186 Cluster_394772 V1221497 FEPD map02010 P transport system permease protein COG0609 Cluster_714963 V1221498 SIDE P Siderophore-interacting protein COG2375 Cluster_238613 V1221500 M domain protein COG4932 Cluster_543006 V1221501 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_281713 V1221502 DPRA L DNA protecting protein DprA COG0758 Cluster_554767 V1221503 MODC map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_238614 V1221505 M Inherit from COG: YD repeat protein COG3209 Cluster_238615 V1221506 VIRD4 map03070,map05120 U TraG TraD family protein COG3505 Cluster_789222 V1221507 K Transcriptional regulator COG1309 Cluster_669764 V1221508 BL01877 K Transcriptional regulator COG1309 Cluster_279068 V1221509 map00071,map00310,map00380,map01100 I acyl-CoA dehydrogenase domain-containing protein COG1960 Cluster_440959 V1221510 map00480,map00590 O Glutathione peroxidase COG0386 Cluster_321394 V1221512 V restriction enzyme 17CDW@proNOG Cluster_484995 V1221513 map03440 K Transcriptional regulator COG2865 Cluster_751516 V1221514 DCTP C symporter COG1301 Cluster_748094 V1221515 HEMB map00860,map01100,map01110 H delta-aminolevulinic acid dehydratase COG0113 Cluster_355401 V1221516 HEML map00860,map01100,map01110 H Glutamate-1-semialdehyde aminotransferase COG0001 Cluster_892140 V1221517 L NA 0Z8MW Cluster_239887 V1221518 HSDS V Restriction modification system DNA specificity COG0732 Cluster_296782 V1221520 YDIA S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) COG1806 Cluster_579522 V1221525 YKOE S ABC superfamily ATP binding cassette transporter membrane protein COG4721 Cluster_475737 V1221526 PBP2B M penicillin-binding protein COG0768 Cluster_632871 V1221527 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_695910 V1221528 S NA 0Z0KI Cluster_385878 V1221529 S Inherit from NOG: Tail protein 11MY0 Cluster_632872 V1221531 K Bacterial regulatory proteins, tetR family COG1309 Cluster_427099 V1221532 map00230,map00983,map01100 F Glutamine amidotransferase COG0518 Cluster_339561 V1221535 map02010 P Nickel transport complex protein, NikM subunit, transmembrane 11GS3 Cluster_285930 V1221537 I Inherit from COG: acetyl-CoA carboxylase biotin carboxylase COG0439 Cluster_298184 V1221538 FADD map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG0318 Cluster_614105 V1221540 POTB map02010 P ABC transporter, permease COG1176 Cluster_414365 V1221541 POTA map02010 E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COG3842 Cluster_358764 V1221543 SSCG_01128 S secreted protein 124ZH Cluster_368628 V1221548 MELS_0665 L RNA-directed DNA polymerase (Reverse transcriptase) COG3344 Cluster_242535 V1221549 M Cell surface protein COG5295 Cluster_242536 V1221550 DLD map00620 C d-lactate dehydrogenase COG0277 Cluster_766228 V1221551 map00362,map01100,map01120 S domain protein COG1917 Cluster_419724 V1221557 COBL map00860,map01100 H Precorrin-6y C5,15-methyltransferase COG2242 Cluster_847976 V1221558 S Metallo-beta-lactamase superfamily COG0491 Cluster_318434 V1221559 ADHE2 map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map05204 C Dehydrogenase COG1062 Cluster_497114 V1221560 LEGAS_1040 L transposase COG2963 Cluster_560751 V1221561 UBIE map00340,map00350,map00624,map01120 Q methyltransferase COG0500 Cluster_243886 V1221565 M Inherit from NOG: Polymorphic outer membrane protein 11KKP Cluster_596102 V1221566 ARGS map00970 J arginyL-tRNA synthetase COG0018 Cluster_380566 V1221568 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_245160 V1221569 S NA 0ZHVH Cluster_302221 V1221570 DPPD E, P (ABC) transporter COG0444 Cluster_287336 V1221572 PYRC map00240,map01100 F dihydroorotase COG0044 Cluster_705358 V1221573 SCPA S Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) COG1354 Cluster_391148 V1221574 CMTA S Trehalose corynomycolyl transferase COG0627 Cluster_526077 V1221575 S AIPR protein 0ZFWF Cluster_269744 V1221577 PHOD map00627,map00790,map01100,map01120,map02020 P Alkaline phosphatase COG3540 Cluster_610457 V1221578 MIDI_00056 L Transposase 0YEAS Cluster_336578 V1221579 YPFJ S zinc metallopeptidase COG2321 Cluster_249053 V1221580 HELD map03420,map03430 L helicase COG3973 Cluster_246484 V1221581 PYC map00020,map00620,map00720,map01100,map01120,map01230 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) COG1038 Cluster_246485 V1221582 HEPA L Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) COG0553 Cluster_551904 V1221583 MT1668 S Protein of unknown function (DUF402) COG2306 Cluster_469343 V1221584 S NA 120AV Cluster_380567 V1221585 map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_796960 V1221590 SCLAV_1493 S NA 0XUCQ Cluster_528839 V1221591 SCLAV_1772 S chad domain containing protein 0YY54 Cluster_268399 V1221592 RV1481 S von Willebrand factor, type A COG2304 Cluster_247745 V1221593 DPNA L helicase COG4646 Cluster_606796 V1221594 RPLT map03010 J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) COG0292 Cluster_805098 V1221595 RPMI map03010 J 50s ribosomal protein L35 COG0291 Cluster_414366 V1221596 IRP6B map02010 P Iron chelate uptake ABC transporter, FeCT family, permease protein COG0609 Cluster_687567 V1221597 IRP6A map02010 P Periplasmic binding protein COG0614 Cluster_705359 V1221599 K, T phage shock protein C, PspC COG1983 Cluster_249054 V1221600 HEMD map00860,map01100,map01110 H synthase COG1587 Cluster_480358 V1221601 map00330,map01110,map01230 E Ornithine cyclodeaminase COG2423 Cluster_458865 V1221603 map03440 K Transcriptional regulator COG2865 Cluster_674161 V1221604 RFBA map00521,map00523,map01100,map01110 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) COG1209 Cluster_515160 V1221606 L transposase IS605 OrfB family 0XT7Q Cluster_250313 V1221607 ACTP P p-type atpase COG2217 Cluster_475738 V1221609 LPD map00010,map00020,map00260,map00280,map00620,map01100,map01110,map01120 C dihydrolipoyl dehydrogenase COG1249 Cluster_250314 V1221610 FADF C Fe-S oxidoreductase COG0247 Cluster_507289 V1221611 S Rib/alpha-like repeat 10008 Cluster_352059 V1221612 MTRA map02020 T response regulator COG0745 Cluster_250315 V1221615 ADH map00650 C Dehydrogenase COG1063 Cluster_250316 V1221616 TREB map00010,map00500,map00520,map02060 G phosphotransferase system, EIIB COG1264 Cluster_534416 V1221617 FCOL_03560 S NA 11YT4 Cluster_385879 V1221619 L Inherit from COG: transposase COG3666 Cluster_284488 V1221620 S Zinc finger, swim domain protein COG4279 Cluster_793017 V1221622 LEUC map00290,map00660,map01100,map01110,map01210,map01230 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) COG0065 Cluster_375288 V1221623 LTBR K Iclr family transcriptional regulator COG1414 Cluster_471490 V1221624 TERD T tellurium resistance protein COG2310 Cluster_251532 V1221626 SURB S G5 domain protein 0ZVV3 Cluster_589259 V1221630 RV0191 G integral membrane protein COG2814 Cluster_674162 V1221631 CAS2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) COG3512 Cluster_252747 V1221632 M NA 0YHI1 Cluster_252748 V1221634 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_434893 V1221637 PRIA map03440 L Primosomal protein n' COG1198 Cluster_252749 V1221638 ZWF map00030,map00480,map01100,map01110,map01120 G glucose-6-phosphate 1-dehydrogenase COG0364 Cluster_449017 V1221640 LEMA S LemA family COG1704 Cluster_458866 V1221642 PMT M glycosyl transferase, family 39 COG1928 Cluster_582759 V1221643 S Membrane COG5660 Cluster_657052 V1221644 HSDS V Restriction modification system DNA (Specificity COG0732 Cluster_687568 V1221646 L DNA methylase N-4 N-6 domain-containing protein COG1475 Cluster_268400 V1221649 S Inherit from NOG: domain protein 0XP4A Cluster_256441 V1221657 SURB S G5 domain protein 0ZVV3 Cluster_892142 V1221658 S NA 11IJN Cluster_458867 V1221659 C, O Pfam:DUF255 COG0526 Cluster_347329 V1221660 AARI_34710 L Transposase for insertion sequence 11IYJ Cluster_257732 V1221661 S radical SAM domain protein COG0535 Cluster_264352 V1221662 L Inherit from COG: Type II restriction enzyme, methylase COG1002 Cluster_796962 V1221664 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_450985 V1221665 CTAB map00190,map00860,map01100,map01110 O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) COG0109 Cluster_449018 V1221666 UBIA H Prenyltransferase COG0382 Cluster_603185 V1221667 I Membrane-associated phospholipid phosphatase COG0671 Cluster_256442 V1221668 GLGC map00500,map00520,map01100,map01110 G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) COG0448 Cluster_257733 V1221669 SCLAV_4759 L DNA helicase COG1112 Cluster_497115 V1221670 S NA 11R2V Cluster_526078 V1221671 PURA map00230,map00250,map01100 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis COG0104 Cluster_256443 V1221672 CSN1 L CRISPR-associated protein, Csn1 family COG3513 Cluster_582760 V1221675 IDSA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_528840 V1221676 MT2226 map00350,map00362,map00627,map00642,map00903,map01120 S Gcn5-related n-acetyltransferase COG0456 Cluster_871831 V1221681 YHFR K GntR Family Transcriptional Regulator COG2188 Cluster_365304 V1221682 D cobyrinic Acid a,c-diamide synthase COG1192 Cluster_596104 V1221684 COBT map00860,map01100 H Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) COG2038 Cluster_636901 V1221688 YLBL T Secreted protein COG3480 Cluster_330491 V1221691 S surface protein 11NE4 Cluster_259048 V1221695 ALDA map00010,map00040,map00053,map00071,map00280,map00281,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00626,map00640,map00903,map01100,map01110,map01120 C Aldehyde dehydrogenase family COG1012 Cluster_699185 V1221697 S NA 0ZD0C Cluster_847978 V1221701 S Flavin reductase like domain protein COG1853 Cluster_260353 V1221702 CLPA O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_648849 V1221703 RPLX map03010 J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) COG0198 Cluster_260354 V1221704 MT1814 V Hnh endonuclease 11XHB Cluster_408826 V1221705 S NA 0YHMP Cluster_728154 V1221706 S Membrane COG2860 Cluster_475739 V1221707 PYRF map00240,map01100 F orotidine 5''-phosphate decarboxylase COG0284 Cluster_566904 V1221708 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_632873 V1221711 RECO map03440 L Involved in DNA repair and RecF pathway recombination (By similarity) COG1381 Cluster_444951 V1221712 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_569983 V1221713 SP_1213 S Uncharacterized protein conserved in bacteria (DUF2130) COG4487 Cluster_261675 V1221715 LHR L helicase COG1201 Cluster_636902 V1221717 S mobilization protein 11J0G Cluster_260357 V1221718 RECQ map03018 L ATP-dependent DNA helicase RecQ COG0514 Cluster_260358 V1221721 DPNA L helicase COG4646 Cluster_465124 V1221722 PGPA map00564,map01100 I phosphatidylglycerophosphatase a COG1267 Cluster_365305 V1221724 TPN L transposase COG3316 Cluster_576415 V1221725 IRP6B map02010 P Iron chelate uptake ABC transporter, FeCT family, permease protein COG0609 Cluster_471491 V1221726 FECE map02010 P ABC transporter, ATP-binding protein COG1120 Cluster_589261 V1221727 DHAM G Dihydroxyacetone kinase COG3412 Cluster_275068 V1221728 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_289983 V1221730 C Molybdopterin-binding domain of aldehyde dehydrogenase COG1529 Cluster_471492 V1221731 LUXS map00270,map05111 T Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) COG1854 Cluster_361994 V1221733 DAPA map00300,map01100,map01110,map01120,map01230 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) COG0329 Cluster_279069 V1221735 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_262974 V1221738 SUCB map00010,map00020,map00280,map00310,map00620,map01100,map01110,map01120 C 2-oxoglutarate dehydrogenase E2 component, dihydrolipoamide succinyltransferase COG0508 Cluster_312256 V1221739 MEND map00130,map01100,map01110 H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) COG1165 Cluster_492125 V1221743 MAF D Maf-like protein COG0424 Cluster_537317 V1221744 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_744746 V1221745 BMUL_0586 map00051,map00520,map01100,map01110 M Nucleotidyl transferase COG1208 Cluster_644792 V1221749 map02010 S NA 0ZQE4 Cluster_432977 V1221750 STPC map02010 P ABC transporter COG1131 Cluster_283113 V1221751 PEPN map00480,map01100 E aminopeptidase N COG0308 Cluster_285931 V1221752 DPPB map02010 P Binding-protein-dependent transport systems inner membrane component COG0601 Cluster_312257 V1221753 L transposase IS605 OrfB family 0XT7Q Cluster_262975 V1221756 AARI_34870 L transposase of ISAar22, IS481 family COG2801 Cluster_484997 V1221758 S conjugative transposon protein TraQ 11SF8 Cluster_446994 V1221761 NDVA2 V ABC transporter, ATP-binding protein COG1132 Cluster_310729 V1221762 CLCAR_0322 D domain protein COG5279 Cluster_342534 V1221763 SP_0058 K GntR family transcriptional regulator COG2188 Cluster_579524 V1221764 MRP D ATP-binding protein COG0489 Cluster_589262 V1221765 TATB map03060,map03070 U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) COG1826 Cluster_644793 V1221767 MT0582 S conserved TRANSMEMBRANE PROTEIN 11TI5 Cluster_434894 V1221768 MGTA map00051 M Glycosyl transferase (Group 1 COG0438 Cluster_265682 V1221769 G domain protein COG4193 Cluster_678606 V1221771 S NA 124KR Cluster_277709 V1221772 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_361995 V1221773 SIRR K iron (metal) dependent repressor, dtxr family COG1321 Cluster_669766 V1221775 REPW S Plasmid Encoded RepA Protein 0XSQ6 Cluster_275069 V1221783 V type i restriction COG0732 Cluster_266992 V1221785 YJIN S Membrane COG2733 Cluster_606797 V1221786 SMPB O Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) COG0691 Cluster_695913 V1221787 ARGF map00330,map01100,map01110,map01230 E ornithine carbamoyltransferase COG0078 Cluster_367018 V1221788 L Integrase core domain COG2801 Cluster_446995 V1221790 SSCG_02636 S Protein of unknown function DUF2617 126IP Cluster_410685 V1221792 S NA 0Y83Y Cluster_711592 V1221793 S Cutinase 0YUSA Cluster_499774 V1221795 TRML map04122 J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) COG0219 Cluster_449019 V1221799 S conjugation system ATPase, TraG family 0XSHU Cluster_268401 V1221800 C FMN-binding domain protein COG3976 Cluster_325730 V1022001 S NA 11MMW Cluster_613269 V1022006 S NA 0ZHU9 Cluster_234683 V1022009 CYDA map00190,map01100,map02020 C (Ubiquinol oxidase) subunit I COG1271 Cluster_172707 V1022011 TYPA T gtp-binding protein typa COG1217 Cluster_233494 V1022012 S membrane 0Z8C3 Cluster_808219 V1022013 S NA 11EKD Cluster_215942 V1022016 map00230 Q RelA SpoT domain protein COG2357 Cluster_413992 V1022017 RNFE C Electron transport complex COG4660 Cluster_631963 V1022020 YIFE S UPF0438 protein yifE COG3085 Cluster_733929 V1022021 S Membrane COG0628 Cluster_337799 V1022022 YJJQ K regulatoR 174V6@proNOG Cluster_203746 V1022024 GLTS E Sodium Glutamate Symporter COG0786 Cluster_796109 V1022025 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_458406 V1022026 S VIT family COG1814 Cluster_578763 V1022027 RHLE map03018 L atp-dependent rna helicase COG0513 Cluster_458407 V1022028 M DegT/DnrJ/EryC1/StrS aminotransferase family COG0399 Cluster_325731 V1022033 S NA 0XTZD Cluster_765295 V1022034 BSEL_0787 S Phage terminase small subunit COG3747 Cluster_262724 V1022037 S NA 11JP6 Cluster_205924 V1022038 PURQ map00230,map01100,map01110 F Phosphoribosylformylglycinamidine synthase I COG0047 Cluster_334727 V1022041 CYSH map00920,map01100,map01120 P Reduction of activated sulfate into sulfite (By similarity) COG0175 Cluster_250070 V1022048 V ABC transporter, permease protein 0XP9H Cluster_306289 V1022049 MEPA M peptidase COG0739 Cluster_572446 V1022051 TREZ map00500,map01100,map01110 G maltooligosyl trehalose trehalohydrolase COG0296 Cluster_284222 V1022052 FOLP map00790,map01100 H dihydropteroate synthase COG0294 Cluster_210292 V1022057 GLK map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G Glucokinase COG1940 Cluster_202721 V1022058 map02010 P Iron chelate uptake ABC transporter, FeCT family, permease protein COG0609 Cluster_222944 V1022059 DAPD map00300,map01100,map01120,map01230 E Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) COG2171 Cluster_284223 V1022063 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) COG0706 Cluster_158520 V1022064 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_297930 V1022065 LPXA map00540,map01100 M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) COG1043 Cluster_413993 V1022066 FURR P ferric uptake regulator COG0735 Cluster_159371 V1022067 V Type III COG3587 Cluster_296561 V1022069 YJJH S Phosphohydrolase COG1409 Cluster_769165 V1022075 FEOA P ferrous iron transport protein COG1918 Cluster_581980 V1022076 GCVH map00630,map01110 E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) COG0509 Cluster_159372 V1022077 THIC map00730,map01100 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) COG0422 Cluster_415803 V1022081 WBPC I Acyl-transferase COG1835 Cluster_421151 V1022082 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_239638 V1022084 S Membrane 0XRRH Cluster_346977 V1022085 S NA 11K8T Cluster_160250 V1022086 M Inherit from NOG: Polymorphic outer membrane protein 11KKP Cluster_252487 V1022087 CYSK map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_161071 V1022089 S NA 11W22 Cluster_656171 V1022092 RPLX map03010 J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) COG0198 Cluster_436506 V1022093 RPLE map03010 J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COG0094 Cluster_297931 V1022094 HISD map00340,map01100,map01110,map01230 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) COG0141 Cluster_366690 V1022095 YUGP S zinc metallopeptidase COG2738 Cluster_560065 V1022096 RIMO J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) COG0621 Cluster_313426 V1022098 GLNQ E ABC transporter, ATP-binding protein COG1126 Cluster_733931 V1022099 S membrane 11VWI Cluster_602322 V1022106 M Glycosyl transferase family 2 0ZX2Q Cluster_316582 V1022108 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_330209 V1022109 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_161072 V1022111 O m6 family metalloprotease domain protein COG4412 Cluster_501738 V1022112 S NA 0Z2W5 Cluster_161896 V1022113 S Int_alpha 0ZYU3 Cluster_340737 V1022114 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_161897 V1022116 S NA 0ZN4K Cluster_331779 V1022117 RLUC J pseudouridine synthase COG0564 Cluster_494050 V1022119 SASC S surface protein 11FPX Cluster_331780 V1022120 PHOU P Plays a role in the regulation of phosphate uptake COG0704 Cluster_193279 V1022123 OA307_1435 S DDE_Tnp_IS1595 11G14 Cluster_501739 V1022128 S Lpxtg-motif cell wall anchor domain protein 0XQBH Cluster_167500 V1022129 ACA4 P Calcium-translocating P-type ATPase, PMCA-type COG0474 Cluster_243649 V1022130 RNZ map03013 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) COG1234 Cluster_164346 V1022131 GLPD map00564 C Glycerol-3-phosphate dehydrogenase COG0578 Cluster_262725 V1022132 L Inherit from NOG: Helicase COG1112 Cluster_415804 V1022133 S Short chain dehydrogenase 0XNW1 Cluster_438551 V1022135 G polysaccharide deacetylase COG0726 Cluster_548284 V1022136 S Membrane 0XQTX Cluster_313427 V1022140 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E brancheD-chain amino acid aminotransferase COG0115 Cluster_765296 V1022141 S Conserved domain protein COG4443 Cluster_591855 V1022142 SURE map00230,map00240,map00760,map01100,map01110 F Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) COG0496 Cluster_254998 V1022143 MT0809 C fumarate reductase succinate dehydrogenase flavoprotein domain protein COG3573 Cluster_403189 V1022144 HSPR K merR family transcriptional Regulator COG0789 Cluster_399647 V1022145 EMBC M Arabinosyltransferase 0XSQE Cluster_477455 V1022146 BIOB map00780,map01100 H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) COG0502 Cluster_545242 V1022147 map00280,map00640,map00720,map01100,map01120 E, I B12 binding domain COG2185 Cluster_440534 V1022148 S NA 0YU05 Cluster_169283 V1022149 SGLY_0535 S phage protein 0XNW6 Cluster_385507 V1022150 S NA 0Z23H Cluster_166009 V1022151 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_196795 V1022155 NDVA V ABC superfamily ATP binding cassette transporter COG1132 Cluster_369975 V1022156 S NA 11EPI Cluster_166734 V1022158 S NA 11YT1 Cluster_408458 V1022159 RDGB map00230,map00240,map01100 F Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) COG0127 Cluster_166010 V1022160 SASC S surface protein 11FPX Cluster_253794 V1022161 PHR L deoxyribo-dipyrimidine photolyase COG0415 Cluster_166735 V1022162 POLA_2 L DNA polymerase 0XRUF Cluster_166736 V1022167 PRPE map00230 T Phosphatase COG4639 Cluster_720775 V1022169 WHIB1 K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) 11UDY Cluster_167501 V1022170 S NA 0XSI9 Cluster_167502 V1022176 HTPG map04141,map04151,map04612,map04621,map04626,map04914,map04915,map05200,map05215 O Molecular chaperone. Has ATPase activity (By similarity) COG0326 Cluster_562966 V1022177 ARGB map00330,map01100,map01110,map01210,map01230 E nag kinase COG0548 Cluster_243650 V1022178 YDJI G virion core protein (Lumpy skin disease COG4260 Cluster_253795 V1022179 S NA 11EJ3 Cluster_389064 V1022183 PLSC map00561,map00564,map01100 I Acyl-transferase 0Z3QU Cluster_253796 V1022185 S Sulfatase COG2194 Cluster_514525 V1022186 DKSA S DnaK suppressor protein 11IHW Cluster_368318 V1022187 LSPA map03060 U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) 11G1Y Cluster_673136 V1022188 S NA 0ZHU9 Cluster_438552 V1022189 YRHL I Acyl-transferase COG1835 Cluster_168376 V1022190 BIOA map00780,map01100 H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) COG0161 Cluster_484467 V1022192 CYSE S -acetyltransferase 11PF0 Cluster_169285 V1022194 GLPD1 map00564 C Glycerol-3-phosphate dehydrogenase COG0578 Cluster_169286 V1022197 YBGQ map05133 M outer membrane usher protein COG3188 Cluster_266743 V1022198 GLTD map00250,map00910,map01100,map01110,map01120,map01230 E Glutamate synthase COG0493 Cluster_643897 V1022199 S NA 11KFV Cluster_360089 V1022200 S NA 11XU3 Cluster_294032 V1221801 FOLK map00790,map01100 H 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase COG1539 Cluster_268402 V1221802 WBPC I Acyl-transferase COG1835 Cluster_408827 V1221804 S Membrane COG2860 Cluster_353726 V1221805 RESD map02020 K regulator COG0745 Cluster_268403 V1221807 S NA 0ZV0P Cluster_268404 V1221808 LPDA map00010,map00020,map00260,map00280,map00620,map01100,map01110,map01120 C Flavoprotein disulfide reductase COG1249 Cluster_489628 V1221809 S NA 1294N Cluster_702267 V1221811 FTN map00860 P ferritin COG1528 Cluster_268405 V1221813 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_754970 V1221815 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_828527 V1221816 S NA 0Y0GF Cluster_471493 V1221817 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_322963 V1221819 E Indole-3-glycerolphosphate synthase COG0134 Cluster_391149 V1221820 M YngK protein COG1649 Cluster_273716 V1221822 CYDD map02010 V ABC, transporter COG4988 Cluster_502309 V1221824 S NA 11NJV Cluster_859542 V1221825 UGE map00052,map00500,map00520,map01100,map01110 G, M Male sterility protein COG0451 Cluster_724888 V1221834 RIBD2 H bifunctional deaminase-reductase domain protein COG1985 Cluster_450986 V1221835 P drug resistance transporter, Bcr CflA 0XNNX Cluster_452931 V1221836 S Pyrogenic exotoxin B 11S8V Cluster_368629 V1221838 YHGE S domain protein COG1511 Cluster_401794 V1221840 L Inherit from COG: transposase COG3464 Cluster_863873 V1221842 SCLAV_2569 S NA 121W6 Cluster_606798 V1221843 WBLA K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) 11W0R Cluster_287338 V1221844 S recb family COG2251 Cluster_319913 V1221846 AKR5F C reductase COG0656 Cluster_718211 V1221847 YAAQ S protein from nitrogen regulatory protein P-II COG3870 Cluster_517837 V1221848 SG1639 S Phage-Associated Protein COG3600 Cluster_640929 V1221849 S TraX protein 11N9P Cluster_272382 V1221850 SP_0341 S UPF0371 protein COG4868 Cluster_785226 V1221851 O Peptidyl-prolyl cis-trans isomerase COG0760 Cluster_458868 V1221852 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_333548 V1221853 BMUL_4530 S Protein of unknown function (DUF2891) 0XR9Q Cluster_291298 V1221855 PURM map00230,map01100,map01110 F phosphoribosylaminoimidazole synthetase COG0150 Cluster_273717 V1221856 S Protein of unknown function (DUF3375) 0XQSA Cluster_353727 V1221858 YHFI map00140,map00600 S Beta-lactamase domain-containing protein COG1234 Cluster_273718 V1221859 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_734688 V1221860 L DNA packaging protein 123DA Cluster_275070 V1221861 RV3193C S UPF0182 protein COG1615 Cluster_299465 V1221862 PARE L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_408828 V1221863 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG0194 Cluster_275071 V1221866 ECFA1 map02010 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates COG1122 Cluster_809143 V1221867 AMIA map00360 E amidohydrolase COG1473 Cluster_482670 V1221868 K Helix-turn-helix COG1396 Cluster_275072 V1221871 MT0536 V Hnh endonuclease 122A9 Cluster_836138 V1221872 S Hydrolase COG1011 Cluster_276405 V1221873 L helicase COG4646 Cluster_599620 V1221875 L Transposase 11WA6 Cluster_450987 V1221882 IRC4 S Protein of unknown function (DUF1706) COG4283 Cluster_523159 V1221884 RPLM map03010 J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) COG0102 Cluster_632874 V1221885 MT1173 S Abortive infection protein COG1266 Cluster_531635 V1221889 PPIB O PPIases accelerate the folding of proteins (By similarity) COG0652 Cluster_408829 V1221890 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_614107 V1221891 S NA 11HZH Cluster_392962 V1221894 NORM V Mate efflux family protein COG0534 Cluster_554768 V1221895 S NA 0XQ5J Cluster_665454 V1221896 L NA 0YJFA Cluster_699187 V1221897 L NA 0YKV1 Cluster_648851 V1221898 S NA 1APRV@spiNOG Cluster_517838 V1221900 GLGB map00500,map01100,map01110 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) COG0296 Cluster_708458 V1221901 PHOH T Phoh family COG1702 Cluster_432978 V1221902 S NA 11H67 Cluster_352060 V1221904 BLT G major facilitator superfamily 0ZVHM Cluster_863874 V1221905 YOCS S Bile acid COG0385 Cluster_674163 V1221908 SCLAV_5203 S ABC transporter COG0488 Cluster_417952 V1221909 YJHA S Endonuclease Exonuclease phosphatase 0XNVA Cluster_610460 V1221910 L transposase 11GFI Cluster_652935 V1221911 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_731468 V1221913 RPSP map03010 J 30s ribosomal protein S16 COG0228 Cluster_721542 V1221915 S NA 0Y92Z Cluster_699188 V1221917 S CHAP domain 0ZJI2 Cluster_458869 V1221919 LMAA S antigen A COG5437 Cluster_599621 V1221922 V Type III COG3587 Cluster_576416 V1221923 S NA 0Z7KY Cluster_305175 V1221924 P Pfam:C4dic_mal_tran COG1275 Cluster_280372 V1221925 TRAG map03070 U TraG TraD family protein COG3505 Cluster_800906 V1221927 S NA 0YKUS Cluster_534418 V1221928 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_728155 V1221929 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_648852 V1221933 TFOX K TfoX, N-terminal domain protein COG3070 Cluster_731469 V1221934 S beta-propeller domains of methanol dehydrogenase type COG1512 Cluster_537318 V1221937 MT3340 S Phosphoribosyl transferase domain COG1040 Cluster_557685 V1221938 LPQB S lipoprotein lpqb 0ZF99 Cluster_576417 V1221939 RPLQ map03010 J 50S ribosomal protein l17 COG0203 Cluster_549003 V1221940 RPSL map03010 J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) COG0048 Cluster_683136 V1221941 LSA_07090 L Transposase COG2963 Cluster_281715 V1221942 U, W Pfam:YadA COG5295 Cluster_361996 V1221945 ENDA S DNA-entry nuclease 12175 Cluster_281716 V1221946 TRAG2 S conjugation system ATPase, TraG family 0XSHU Cluster_711595 V1221947 S NA 121AE Cluster_520385 V1221948 T response regulator COG0745 Cluster_283114 V1221950 S NA 11NI8 Cluster_582761 V1221952 S Membrane 0ZWJJ Cluster_534419 V1221953 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_463035 V1221955 VIRE2 S Virulence-associated protein e COG5545 Cluster_789224 V1221960 CRO K HTH_XRE 0XYF7 Cluster_781102 V1221963 S Toxic component of a toxin-antitoxin (TA) module. A 11NP2 Cluster_394774 V1221964 NDVA V ABC superfamily ATP binding cassette transporter COG1132 Cluster_531636 V1221968 TRPC map00400,map01100,map01110,map01230 E Indole-3-glycerol phosphate synthase COG0135 Cluster_412497 V1221970 N Cell surface protein 0XQ7Y Cluster_283116 V1221972 PKS13 Q PKS_AT COG3321 Cluster_428997 V1221975 RECB L recb family COG2887 Cluster_718212 V1221976 F formate-tetrahydrofolate ligase COG2759 Cluster_285933 V1221979 PKS13 Q PKS_AT COG3321 Cluster_285934 V1221980 MAQU_3187 L Integrase catalytic subunit COG4584 Cluster_585945 V1221981 ACPS map00770 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) COG0736 Cluster_515161 V1221983 CLOLE_0796 L recT protein COG3723 Cluster_589265 V1221984 LIN1243 S domain protein COG1235 Cluster_452932 V1221985 CASE L crispr-associated protein 0XPHC Cluster_285935 V1221987 DPPA map02010 E ABC transporter substrate-binding protein COG4166 Cluster_531637 V1221988 PURM map00230,map01100,map01110 F phosphoribosylaminoimidazole synthetase COG0150 Cluster_405381 V1221989 HSDS V Restriction modification system DNA (Specificity COG0732 Cluster_545946 V1221991 CAS1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) COG1518 Cluster_285936 V1221992 RLUC2 J pseudouridine synthase COG0564 Cluster_820717 V1221993 RIBF map00740,map01100 H riboflavin biosynthesis protein ribF COG0196 Cluster_657053 V1222000 L DNA Methylase COG2189 Cluster_477946 V1222001 V Type III COG3587 Cluster_648854 V1222002 S Filamentation induced by cAMP protein fic 11MJJ Cluster_285937 V1222003 V Eco57I restriction-modification methylase COG1002 Cluster_287340 V1222005 S NA 0ZBRU Cluster_287341 V1222007 FTSK D cell division protein FtsK COG1674 Cluster_288695 V1222008 S Rib/alpha-like repeat 10008 Cluster_487269 V1222009 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_610461 V1222010 S Protein of unknown function DUF45 COG1451 Cluster_582762 V1222012 LCD map00270,map00450,map00920,map01100,map01110,map01230 E Aminotransferase class I and II COG1168 Cluster_520386 V1222013 RPLM map03010 J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) COG0102 Cluster_380568 V1222015 S peptidase, S41 11U77 Cluster_515162 V1222016 METG J emap domain COG0073 Cluster_288696 V1222017 TEX K domain protein COG2183 Cluster_813129 V1222019 S NA 0ZZPX Cluster_425168 V1222020 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_465125 V1222021 RRMJ J Hemolysin A COG1189 Cluster_449020 V1222023 BIOY map02010 S bioY protein COG1268 Cluster_403571 V1222025 M Peptidase family S41 COG0793 Cluster_454963 V1222029 YQEG V had superfamily (subfamily IIIa) phosphatase COG2179 Cluster_599622 V1222035 K Transcriptional regulator, GntR family COG1725 Cluster_800907 V1222038 LEUB map00290,map01100,map01110,map01210,map01230 C, E Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) COG0473 Cluster_714966 V1222042 SP_0207 map00240,map00983,map01100 S phosphoribulokinase uridine kinase 11JPM Cluster_711597 V1222043 PSPC S phage shock protein C, PspC COG1983 Cluster_504713 V1222044 S peptidase, S41 11FNN Cluster_291299 V1222045 M Putative cell wall binding repeat 2 COG2247 Cluster_469344 V1222046 map02010 S ABC-2 type transporter 11H02 Cluster_640930 V1222047 map02010 S ABC-2 type transporter 11HPT Cluster_389419 V1222049 RES V Type III COG3587 Cluster_509878 V1222050 COMEB map00240,map01100 F deaminase COG2131 Cluster_582763 V1222054 SCLAV_0650 S ankyrin repeat-containing protein COG0666 Cluster_428998 V1222057 MSMK map02010 G (ABC) transporter COG3839 Cluster_773632 V1222059 MSRB O reductase COG0229 Cluster_408830 V1222060 AFTC S integral membrane protein 0XT56 Cluster_338125 V1222061 RLUB J Pseudouridine synthase COG1187 Cluster_335053 V1222062 FAT map00061,map01100 I Acyl-ACP thioesterase COG3884 Cluster_442973 V1222065 CFP6 S low molecular weight protein antigen 6 127P8 Cluster_416147 V1222067 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_714967 V1222068 HUP L DNA-binding protein COG0776 Cluster_292659 V1222069 YPFJ S zinc metallopeptidase COG2321 Cluster_367019 V1222070 M acetyltransferase COG1247 Cluster_497116 V1222071 PCP O Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) COG2039 Cluster_832245 V1222072 MT1149 S Antibiotic biosynthesis monooxygenase COG1359 Cluster_412498 V1222073 S May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) COG1162 Cluster_754973 V1222075 NRDH O (Glutaredoxin-like protein) NrdH COG0695 Cluster_816912 V1222076 RPMJ map03010 J 50S ribosomal protein L36 COG0257 Cluster_432979 V1222077 ACTP P p-type ATPase COG2217 Cluster_384111 V1222079 S NA 1119B Cluster_777359 V1222080 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_674164 V1222081 K Transcription factor WhiB 0YYTM Cluster_423382 V1222086 PNCA map00760,map01100 Q isochorismatase COG1335 Cluster_549004 V1222087 S Protein of unknown function (Porph_ging) 124PH Cluster_391150 V1222088 L DNA alkylation repair enzyme 0YG23 Cluster_294033 V1222090 FEPD map02010 P transport system permease protein COG0609 Cluster_294034 V1222091 map00270,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01230 E Aminotransferase class i COG1448 Cluster_347330 V1222092 S NA 11XKP Cluster_738017 V1222093 FADD10 map00071,map00130,map00360,map00627,map00640,map00903,map00930,map00940,map00960,map01100,map01110,map01120,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG0318 Cluster_557686 V1222094 SERB map00260,map00680,map01100,map01120,map01230 E phosphoserine phosphatase COG3830 Cluster_614109 V1222096 MT2225 S Membrane 124IY Cluster_695914 V1222097 CSM map00400,map01100,map01110,map01230 E chorismate mutase COG1605 Cluster_625326 V1222098 MHUD S Antibiotic biosynthesis monooxygenase COG2329 Cluster_785229 V1222100 RPLN map03010 J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) COG0093 Cluster_606799 V1222101 TRAI S Conjugative transposon protein TraI 0YE08 Cluster_295441 V1222104 SECA2 map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_345746 V1222107 DDH map00300,map01100,map01110,map01230 E Diaminopimelate dehydrogenase 0XPX2 Cluster_502310 V1222108 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii, epsilon subunit COG0847 Cluster_805102 V1222109 S Gnat family 0ZMKQ Cluster_708459 V1222110 SP_0119 L Nudix family COG0494 Cluster_385880 V1222111 TRKH P Potassium uptake protein COG0168 Cluster_528841 V1222112 FEPC map02010 P ABC, transporter COG1120 Cluster_724889 V1222113 FEPG map02010 P transport system, permease COG4779 Cluster_392963 V1222115 NATB C, P ABC transporter, permease COG1668 Cluster_295442 V1222116 V Type I restriction modification DNA specificity domain 18CYQ@proNOG Cluster_295443 V1222117 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_487270 V1222118 ATPB map00190,map00195,map01100 C it plays a direct role in the translocation of protons across the membrane (By similarity) COG0356 Cluster_582764 V1222119 S NA 0YIA5 Cluster_347331 V1222120 S Protein of unknown function (DUF3068) 0ZPTM Cluster_489629 V1222126 S Uncharacterized protein conserved in bacteria (DUF2236) COG3662 Cluster_410686 V1222130 M Cell wall anchor domain protein 11Q8J Cluster_296783 V1222131 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_573192 V1222132 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_777361 V1222133 map03440 K Transcriptional regulator COG2865 Cluster_303670 V1222134 TEH_04490 J HAD-superfamily hydrolase subfamily IA variant 3 COG0637 Cluster_526081 V1222135 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_644796 V1222136 S NA 11VY9 Cluster_428999 V1222139 map00630,map00680,map01100,map01120 C molybdopterin oxidoreductase fe4s4 region COG0243 Cluster_731470 V1222140 LSA_01360 L transposase COG0675 Cluster_721544 V1222141 RGPD map02010 P abc transporter COG1134 Cluster_449021 V1222142 RGPC map02010 V ABC-2 type transporter COG1682 Cluster_298185 V1222144 S Rib/alpha-like repeat 10008 Cluster_754974 V1222145 YEHR S (LipO)protein COG4808 Cluster_809144 V1222146 YYZM S protein, conserved in bacteria COG4481 Cluster_321395 V1222147 PSSA map00260,map00564,map01100 I cdpdiacylglycerol-serine O-phosphatidyltransferase COG1183 Cluster_573193 V1222152 S NA 0Z7KY Cluster_298186 V1222154 S Family of unknown function (DUF490) 0ZVTR Cluster_298188 V1222156 S Domain of unknown function (DUF222) 0ZBYA Cluster_299466 V1222157 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_370340 V1222158 C Nitroreductase COG0778 Cluster_298189 V1222159 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG0469 Cluster_425169 V1222162 E, G Membrane COG0697 Cluster_475740 V1222164 PROA map00330,map01100,map01230 E Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) COG0014 Cluster_341013 V1222168 MSHD S Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) COG0456 Cluster_813130 V1222169 MT3785 S metallophosphoesterase COG1408 Cluster_452933 V1222171 K, L Inherit from COG: helicase COG0553 Cluster_363566 V1222172 S Protein of unknown function (DUF402) COG2306 Cluster_299467 V1222173 S NA 0Z0R9 Cluster_300833 V1222174 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_300834 V1222175 PGM map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase (EC 5.4.2.2 COG0033 Cluster_382338 V1222176 REP L Replication Protein COG5527 Cluster_347332 V1222177 S Metal dependent hydrolase COG2220 Cluster_844077 V1222178 S NA 11XPU Cluster_300835 V1222179 S NA 0Y8K6 Cluster_446996 V1222180 RPSI map03010 J 30S ribosomal protein S9 COG0103 Cluster_324537 V1222181 IRP6B map02010 P Iron chelate uptake ABC transporter, FeCT family, permease protein COG0609 Cluster_625327 V1222183 MEND map00130,map01100,map01110 H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) COG1165 Cluster_632875 V1222186 L Inherit from COG: transposase COG3666 Cluster_582765 V1222187 E Peptidase dimerisation domain COG1473 Cluster_300836 V1222188 S NA 122HI Cluster_367020 V1222189 ADHA map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120 C alcohol dehydrogenase COG1064 Cluster_300837 V1222190 S nhl repeat containing protein 12C7Q Cluster_589266 V1222191 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_657054 V1222192 L NA 1004T Cluster_789227 V1222193 BMUL_5652 L Transposase COG2801 Cluster_465126 V1222194 FOLA map00670,map00790,map01100 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) COG0262 Cluster_344122 V1222196 I, Q Short-chain dehydrogenase reductase Sdr COG1028 Cluster_414369 V1222197 S Inherit from NOG: (LipO)protein 103B0 Cluster_302222 V1222198 S NA 0YP9M Cluster_310730 V1222199 D Conjugative transposon protein TraA 0Y9K3 Cluster_300839 V1222203 PBUX F permease COG2233 Cluster_300840 V1222204 TILS map00230,map00983,map01100,map01110 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) COG0037 Cluster_573194 V1222205 map00330,map00360,map00380,map00627,map00643,map01120 C Acetamidase formamidase COG2421 Cluster_504714 V1222206 POXB map00620,map01100 C pyruvate dehydrogenase COG0028 Cluster_781103 V1222207 HSPR K merR family transcriptional Regulator COG0789 Cluster_329093 V1222208 YNFM G Major Facilitator Superfamily 0XP8J Cluster_391151 V1222211 CSP1 M LGFP repeat COG5479 Cluster_394776 V1222212 S Thiol disulfide interchange protein DsbD 1AKF0@sphNOG Cluster_302224 V1222213 PUTA map00250,map00330,map01100,map01110 C Dehydrogenase COG1012 Cluster_531638 V1222215 PFLA O Pyruvate formate-lyase COG1882 Cluster_377060 V1222216 RADC L DNA repair protein (RadC COG2003 Cluster_863876 V1222217 YEGQ map05120 O Peptidase U32 COG0826 Cluster_416148 V1222219 map02010 P ABC transporter substrate-binding protein 0Y63A Cluster_748098 V1222221 S integral membrane protein 121K9 Cluster_303671 V1222222 S NA 0XVNA Cluster_303672 V1222223 L transposase IS605 OrfB family 0YAQA Cluster_302225 V1222224 S NA 0ZHVH Cluster_303674 V1222226 MT1099 S Membrane COG4425 Cluster_523161 V1222227 S Phage minor capsid protein 2 0ZX9D Cluster_303675 V1222230 CYSK map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_303676 V1222234 S Inherit from NOG: (LipO)protein 1AJM6@sphNOG Cluster_305177 V1222235 RLUB J pseudouridine synthase COG1187 Cluster_427101 V1222238 map02010 P ABC transporter COG1131 Cluster_695915 V1222244 BL03504 S phage major capsid protein, HK97 family 0XTEI Cluster_705361 V1222245 L Pfam:Phage_QLRG 0ZFPV Cluster_867886 V1222247 MSRA O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) COG0225 Cluster_520387 V1222249 MT1099 S Membrane COG4425 Cluster_640932 V1222254 OTSA map00500,map01100 G alpha-alpha-trehalose-phosphate synthase COG0380 Cluster_306563 V1222255 L DNA polymerase 0Y9P0 Cluster_306564 V1222260 KATA map00380,map00630,map01110,map04146,map05014 P catalase COG0753 Cluster_338126 V1222261 HSDR V Type I Restriction COG0610 Cluster_306565 V1222262 SURB S G5 domain protein 0ZVV3 Cluster_375289 V1222264 S Inherit from NOG: DNA repair protein 0XQPN Cluster_307875 V1222266 HEPA L Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) COG0553 Cluster_307876 V1222267 S NA 11NI8 Cluster_523162 V1222268 S NA 117XY Cluster_313745 V1222269 L type iii restriction protein res subunit COG3886 Cluster_582766 V1222271 S NA 0ZHU9 Cluster_385881 V1222274 S Protein of unknown function (DUF664) 12AMH Cluster_625328 V1222276 P Cation efflux protein COG1230 Cluster_398280 V1222281 SCLAV_4952 map00230,map00983,map01100 F Glutamine amido-transferase COG0518 Cluster_477947 V1222283 U, W Inherit from COG: domain protein COG5295 Cluster_828530 V1222284 S NA 0ZX1V Cluster_430971 V1222285 S atpase involved in dna repair 0XRFS Cluster_322964 V1222286 L Inherit from COG: transposase COG3464 Cluster_423383 V1222287 C Alcohol dehydrogenase zinc-binding domain protein COG1063 Cluster_309287 V1222288 S Bacterial protein of unknown function (DUF885) COG4805 Cluster_748100 V1222289 AARI_34710 L Transposase for insertion sequence 11IYJ Cluster_540129 V1222290 TNP7109-31 L Transposase COG3328 Cluster_728157 V1222292 RPST map03010 J Binds directly to 16S ribosomal RNA (By similarity) COG0268 Cluster_352061 V1222294 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_309289 V1222297 DNAG map03030 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 Cluster_403572 V1222298 T Histidine kinase 0ZPYN Cluster_900582 V1222300 YDHQ K Transcriptional regulator COG2188 Cluster_310732 V1222302 GLXK map00260,map00561,map00630,map01100,map01110 G Glycerate kinase COG1929 Cluster_387721 V1222304 S NA 17ZXQ@proNOG Cluster_434895 V1222305 PPX map00230 F, P ppx gppa phosphatase COG0248 Cluster_436952 V1222306 MTR map00010,map00020,map00260,map00280,map00480,map00620,map01100,map01110,map01120 C pyridine nucleotide-disulfide oxidoreductase COG1249 Cluster_816913 V1222307 M Inherit from COG: YD repeat protein COG3209 Cluster_665455 V1222308 map00360,map00362,map00650,map01100,map01120 C 3-hydroxybutyryl-CoA dehydrogenase COG1250 Cluster_576418 V1222309 L Integrase COG0582 Cluster_430972 V1222310 NQR S Nadph-dependent fmn reductase COG0431 Cluster_389420 V1222312 K Tetr family transcriptional regulator 11QBX Cluster_321396 V1222314 ANT_21350 E DNA-binding protein COG2856 Cluster_312258 V1222316 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_614110 V1222317 S Sporulation protein YtfJ 11PTS Cluster_517841 V1222320 ADHE map00010,map00051,map00071,map00350,map00362,map00363,map00591,map00620,map00621,map00622,map00625,map00626,map00650,map01100,map01110,map01120 C Dehydrogenase COG1454 Cluster_888051 V1222322 EXOA map03410 L Exodeoxyribonuclease III COG0708 Cluster_436953 V1222323 BIOB map00780,map01100 H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) COG0502 Cluster_489630 V1222324 S cytosolic protein 0XSPM Cluster_832247 V1222325 S NA 125TX Cluster_380569 V1222326 DIPZ O cytochrome biogenesis protein DipZ COG0785 Cluster_313746 V1222327 COBQ map00860,map01100,map02010 H catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) COG1492 Cluster_313747 V1222328 SCRB map00052,map00500,map01100 G sucrose-6-phosphate hydrolase COG1621 Cluster_315330 V1222329 D, Z regulator of chromosome condensation, RCC1 COG5184 Cluster_315331 V1222330 CLPL O ATP-dependent Clp protease ATP-binding subunit COG0542 Cluster_534421 V1222332 MENF map00130,map01053,map01100,map01110 H Isochorismate synthase COG1169 Cluster_629052 V1222333 MEND map00130,map01100,map01110 H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) COG1165 Cluster_463036 V1222335 S NA 0ZXY2 Cluster_315332 V1222336 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_365306 V1222341 AMY13I map00500,map01100,map04973 G Alpha-amylase COG0366 Cluster_454964 V1222342 SSEA map00270,map01100,map04122 P sulfurtransferase COG2897 Cluster_741442 V1222343 LEUC map00290,map00300,map00660,map01100,map01110,map01210,map01230 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) COG0065 Cluster_512459 V1222344 LEUD map00290,map00300,map00660,map01100,map01110,map01210,map01230 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) COG0066 Cluster_625329 V1222345 L recombinase (Phage integrase family) COG0582 Cluster_507290 V1222346 V restriction COG0732 Cluster_414370 V1222347 V Mate efflux family protein COG0534 Cluster_494609 V1222348 S metal-dependent hydrolase COG1451 Cluster_718213 V1222349 SCLAV_4061 S Uncharacterised conserved protein (DUF2342) COG5282 Cluster_820718 V1222351 ACEAR_0872 L Transposase, IS605 OrfB family 0XT7Q Cluster_316859 V1222353 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_537319 V1222356 S Pfam:YadA 0YNSE Cluster_414371 V1222357 SUFD O feS assembly protein SufD COG0719 Cluster_840010 V1222358 SUFB O FeS assembly protein SUFB COG0719 Cluster_341014 V1222360 TNPB L integrase catalytic COG2801 Cluster_504715 V1222361 BETA map00260,map01100 E Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) COG2303 Cluster_394778 V1222362 TRKA P potassium transporter peripheral membrane COG0569 Cluster_412499 V1222363 P Sodium hydrogen exchanger 0ZT2S Cluster_847984 V1222366 ADDA L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation COG1074 Cluster_318436 V1222376 COMEC S Competence protein COG2333 Cluster_512461 V1222377 RPLI map03010 J Binds to the 23S rRNA (By similarity) COG0359 Cluster_417953 V1222378 UNG L uracil-dna glycosylase COG1573 Cluster_909030 V1222379 RPMJ map03010 J 50S ribosomal protein L36 COG0257 Cluster_579526 V1222380 NADE map00760,map01100 H nh(3)-dependent nad( ) synthetase COG0171 Cluster_318437 V1222381 GLGB map00500,map01100,map01110 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) COG0296 Cluster_758500 V1222382 COPZ map04978 P heavy metal transport detoxification protein 0XUQ1 Cluster_560752 V1222383 S Abi-like protein 11WV5 Cluster_371960 V1222384 UPP map00240,map01100 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) COG0035 Cluster_319914 V1222385 LHR L helicase COG1201 Cluster_319915 V1222386 G Major Facilitator COG2814 Cluster_319916 V1222388 S Pfam:DUF88 COG1432 Cluster_582767 V1222389 PLSC map00561,map00564,map01100 I Acyl-transferase COG0204 Cluster_596105 V1222390 GLK map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G Glucokinase COG1940 Cluster_319918 V1222392 M Inherit from NOG: Polymorphic outer membrane protein 11KKP Cluster_352062 V1222394 COAA map00770,map01100 H pantothenic acid kinase COG1072 Cluster_614111 V1222396 YLBE map00051,map00363,map00591,map00625,map00650,map01100,map01120 G, M epimerase dehydratase COG0702 Cluster_319920 V1222397 S nlpC P60 family protein 0ZVM8 Cluster_543007 V1222398 V type I restriction modification DNA specificity domain COG0732 Cluster_319921 V1222399 T Pasta domain containing protein COG2815 Cluster_319922 V1222400 T Histidine kinase COG4585 Cluster_781104 V1222402 INFA J however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) COG0361 Cluster_389421 V1222404 APEB E M18 family aminopeptidase COG1362 Cluster_321397 V1222405 S NA 0Z3TH Cluster_321398 V1222407 V type II restriction enzyme, methylase subunit COG1002 Cluster_517842 V1222410 PRFC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) COG4108 Cluster_378833 V1222414 MDLB map02010 V ABC transporter COG1132 Cluster_520388 V1222417 map00270,map01100,map04122 P sulfurtransferase COG2897 Cluster_400005 V1222419 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_434896 V1222420 K Tetr family transcriptional regulator 11TPI Cluster_534422 V1222422 HRCA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) COG1420 Cluster_389422 V1222426 NUC L nuclease COG1525 Cluster_640934 V1222427 SECE map03060,map03070 U Preprotein translocase SecE subunit 0XUXP Cluster_419725 V1222428 map00360,map00362,map00650,map01100,map01120 C Dehydrogenase COG1250 Cluster_322965 V1222429 PURB map00230,map00250,map01100,map01110 F Adenylosuccinate lyase COG0015 Cluster_504716 V1222430 NRDR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) COG1327 Cluster_875921 V1222431 HRPA L ATP-dependent helicase COG1643 Cluster_322967 V1222433 TRAA L TrwC relaxase COG0507 Cluster_766231 V1222436 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_440960 V1222437 map00051,map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 G Glycosyl hydrolase family 20 COG3525 Cluster_324540 V1222438 HELY L helicase COG4581 Cluster_738020 V1222440 L Integrase COG0582 Cluster_683137 V1222441 TATA map03060,map03070 U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) 0XUF0 Cluster_512462 V1222442 TATC map03060,map03070 U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) COG0805 Cluster_368630 V1222443 TNPB L integrase catalytic COG2801 Cluster_721545 V1222447 S ABC transporter COG4586 Cluster_534423 V1222448 DDE_1233 L Integrase catalytic subunit COG2801 Cluster_816914 V1222449 map00071,map00310,map00380,map01100 I Dehydrogenase COG1960 Cluster_338127 V1222452 MEPA M peptidase COG0739 Cluster_851763 V1222453 RIBX S Pfam:DUF2581 11VXH Cluster_454965 V1222454 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_324541 V1222455 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_540130 V1222457 S ATP GTP-binding protein 0XNYD Cluster_347333 V1222459 S copper amine 11ICU Cluster_744752 V1222460 S NA 185WS@proNOG Cluster_326034 V1222464 S nucleoside recognition domain protein COG3314 Cluster_324542 V1222465 V Type I restriction modification system COG0286 Cluster_324543 V1222467 M Inherit from NOG: Polymorphic outer membrane protein 11KKP Cluster_326035 V1222468 PEPD map02020 O Peptidase s1 and s6 chymotrypsin hap COG0265 Cluster_324545 V1222471 M peptidase, S41 COG0793 Cluster_326036 V1222472 COPB P p-type atpase COG2217 Cluster_326037 V1222473 CRR map00010,map00500,map00520,map02060 G Pts system COG2190 Cluster_326038 V1222475 P TonB-linked outer membrane protein, SusC RagA family 0ZWIF Cluster_432980 V1222476 S NA 0ZQXB Cluster_326039 V1222477 PFLB map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_560753 V1222478 SP_1064 L transposase COG1943 Cluster_375290 V1222479 S NA 1241G Cluster_347334 V1222480 DAM map03430 L Dna adenine methylase COG0338 Cluster_326040 V1222481 M domain protein COG4932 Cluster_458870 V1222482 map00052,map02060 G PTS System COG2893 Cluster_515165 V1222483 S Holin family 0XZRF Cluster_702268 V1222484 M hydrolase, family 25 COG3757 Cluster_847985 V1222485 MSRB O reductase COG0229 Cluster_429001 V1222486 YWFI S chlorite dismutase COG3253 Cluster_327597 V1222487 MRAY map00550,map01100 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) COG0472 Cluster_326041 V1222489 S NA 0Z34Z Cluster_327598 V1222490 BETP P Transporter COG1292 Cluster_773634 V1222491 S Protein of unknown function (DUF3039) 11WTE Cluster_456898 V1222492 SDRA V type iii restriction COG1061 Cluster_355402 V1222494 L transposase COG0675 Cluster_327599 V1222496 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase ii COG0046 Cluster_327600 V1222497 M Glycosyltransferase, group 2 family protein COG0463 Cluster_327601 V1222499 S Cutinase 0YUSA Cluster_813132 V1222502 S NA 0YPHQ Cluster_329094 V1222503 LNT M Transfers the fatty acyl group on membrane lipoproteins (By similarity) COG0815 Cluster_329095 V1222504 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_531639 V1222507 K Transcriptional regulator 1296U Cluster_543008 V1222508 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_327602 V1222509 NRDE map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_724890 V1222510 YBFH E, G Membrane COG0697 Cluster_499776 V1222511 S Endonuclease Exonuclease phosphatase 0ZJ9Y Cluster_327603 V1222513 MANC map00051,map00520,map00540,map01100,map01110 M Nucleotidyl transferase COG1208 Cluster_585948 V1222514 S recombinase 11R6K Cluster_329096 V1222515 MT0398 C oxidoreductase COG0543 Cluster_430973 V1222516 SECF map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) COG0341 Cluster_329097 V1222518 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_523163 V1222519 YNFM G Major Facilitator Superfamily 0XP8J Cluster_389423 V1222523 AARI_34710 L Transposase for insertion sequence 11IYJ Cluster_329098 V1222524 RARA L recombination factor protein RarA COG2256 Cluster_621545 V1222527 ARSR K Transcriptional regulator, arsR family COG0640 Cluster_456899 V1222528 G Major Facilitator superfamily 0XT9M Cluster_329099 V1222529 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_361997 V1222530 SCLAV_0069 S Membrane COG2311 Cluster_392965 V1222531 DAPE map00300,map00330,map01100,map01110,map01120,map01210,map01230 E succinyl-diaminopimelate desuccinylase COG0624 Cluster_473603 V1222533 LYSA2 M Glyco_25 COG3757 Cluster_330492 V1222536 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_330493 V1222537 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_695916 V1222538 ATPD map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG1394 Cluster_341015 V1222539 ISDF map02010 P ABC transporter, permease COG0609 Cluster_332053 V1222543 ARGJ map00330,map01100,map01110,map01210,map01230 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) COG1364 Cluster_449022 V1222551 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_773635 V1222553 PROTEASE map05120 O peptidase, U32 COG0826 Cluster_365307 V1222555 U type ii secretion system protein e COG4962 Cluster_509880 V1222558 K Transcriptional regulator 11ZU6 Cluster_332055 V1222561 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_332056 V1222562 S NA 11NI8 Cluster_471497 V1222563 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_333550 V1222564 NAMU_0131 L Integrase COG2801 Cluster_429002 V1222565 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_333551 V1222566 V ABC transporter COG1132 Cluster_678608 V1222570 PCCB I carboxylase, beta COG4799 Cluster_332057 V1222571 S NA 11F8K Cluster_333552 V1222572 PCKG map00010,map00020,map00620,map01100,map01110,map01120,map03320,map04151,map04910,map04920,map04964 C Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) COG1274 Cluster_614112 V1222573 S CAAX amino terminal protease family 0XUJM Cluster_333553 V1222574 DNAE2 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase (By similarity) COG0587 Cluster_714970 V1222575 RPSP map03010 J 30s ribosomal protein S16 COG0228 Cluster_766232 V1222576 YLQC S UPF0109 protein COG1837 Cluster_813133 V1222579 S -acetyltransferase COG2388 Cluster_754976 V1222580 S NA 0Z4VD Cluster_545947 V1222581 S NA 0ZQJ3 Cluster_773636 V1222582 S NA 0XZ2W Cluster_333555 V1222586 SDAC E Serine transporter COG0814 Cluster_543009 V1222587 RPLO map03010 J Binds to the 23S rRNA (By similarity) COG0200 Cluster_824706 V1222588 RPMD map03010 J 50S ribosomal protein L30 COG1841 Cluster_370341 V1222589 RLUB J pseudouridine synthase COG1187 Cluster_333556 V1222590 ESSC D ftsk spoIIIe COG1674 Cluster_333557 V1222591 BDHA map00051,map00363,map00591,map00625,map00650,map01100,map01120 C alcohol dehydrogenase COG1979 Cluster_551907 V1222593 SP_0239 S UPF0210 protein COG2848 Cluster_482671 V1222595 S Domain of unknown function (DUF1896) 0YBI2 Cluster_606801 V1222596 CMTR K arsR family transcriptional regulator COG0640 Cluster_482672 V1222597 RIMP S Required for maturation of 30S ribosomal subunits (By similarity) COG0779 Cluster_335054 V1222598 M Glycosyl hydrolase, family 25 COG3757 Cluster_335055 V1222599 WBPC I Acyl-transferase COG1835 Cluster_335056 V1222600 CAS1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) COG1518 Cluster_392966 V1222601 DCM map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_335057 V1222602 HSDM V N-6 DNA Methylase COG0286 Cluster_367022 V1222604 L helicase COG4646 Cluster_442974 V1222608 PVDL Q Peptide synthase COG0318 Cluster_336579 V1222609 CDR P pyridine nucleotide-disulfide oxidoreductase COG0607 Cluster_382339 V1222610 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_335058 V1222611 DEAD map03018 L RNA helicase COG0513 Cluster_614113 V1222615 PCCB I carboxylase, beta COG4799 Cluster_336580 V1222618 L DNA Methylase COG2189 Cluster_748102 V1222619 TOPB L Dna topoisomerase COG0550 Cluster_335059 V1222620 VANS T Histidine kinase COG0642 Cluster_341016 V1222622 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_385883 V1222623 S Inherit from COG: ATPase (AAA COG1373 Cluster_361998 V1222624 EBA2484 L AtP-binding protein COG1484 Cluster_336581 V1222625 S NA 0XZRS Cluster_336582 V1222627 YBHI P transporter COG0471 Cluster_855545 V1222628 YBIT S ABC transporter COG0488 Cluster_336583 V1222632 L Transposase COG0675 Cluster_465128 V1222633 THYX map00240,map00340,map00350,map00624,map00670,map01120 F Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) COG1351 Cluster_440963 V1222635 SSCG_04455 S Methyltransferase 0XSGP Cluster_432981 V1222637 S NA 0YNJV Cluster_446997 V1222641 MT3774 O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG0526 Cluster_345747 V1222646 map02010 P transporter substrate-binding protein COG1840 Cluster_338128 V1222648 S Inherit from NOG: Histidine triad protein 11G35 Cluster_432982 V1222650 S Mu Gam family protein 127RT Cluster_430974 V1222652 K Tetr family transcriptional regulator 11VWQ Cluster_813134 V1222653 RPIB map00030,map00710,map01100,map01110,map01120,map01230 G Ribose/Galactose Isomerase COG0698 Cluster_454966 V1222654 Q DSBA oxidoreductase 0ZVBB Cluster_589267 V1222656 GLUA map02010 E ABC transporter, ATP-binding protein COG1126 Cluster_744753 V1222657 MIAB J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) COG0621 Cluster_336585 V1222658 GCVT map00260,map00670,map00910,map01100 E The glycine cleavage system catalyzes the degradation of glycine (By similarity) COG0404 Cluster_400006 V1222659 IOLTA G ABC transporter substrate-binding protein COG1879 Cluster_338129 V1222663 S domain protein COG3428 Cluster_338130 V1222664 MURF map00300,map00550,map01100 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) COG0770 Cluster_347335 V1222665 map02010 P Cobalt transport protein COG0619 Cluster_338131 V1222666 CAFA map03018 J ribonuclease COG1530 Cluster_440964 V1222667 NRDF map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_452934 V1222668 DPRE2 I, Q short-chain dehydrogenase reductase COG1028 Cluster_338132 V1222669 map05132 M repeat protein COG3209 Cluster_543010 V1222670 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_762261 V1222671 RPLK map03010 J This protein binds directly to 23S ribosomal RNA (By similarity) COG0080 Cluster_338133 V1222673 S NA 16TDB@proNOG Cluster_339563 V1222674 map02010 S NA 0ZQE4 Cluster_396560 V1222676 GBRO_2584 L integrase family COG0582 Cluster_338134 V1222677 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_487271 V1222678 SLGD_00064 map02010 P ABC transporter COG1122 Cluster_378835 V1222681 M glycosyl transferase family COG0463 Cluster_469345 V1222682 L DNA alkylation repair enzyme COG4912 Cluster_614114 V1222683 GARA T fha domain-containing protein COG1716 Cluster_625330 V1222684 SECA2 map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_758501 V1222685 ACPP I Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) COG0236 Cluster_339564 V1222687 Q Putative Ig domain COG2931 Cluster_458871 V1222688 GLNP E glutamine ABC transporter, permease protein COG0765 Cluster_339565 V1222690 HSDS V type I restriction-modification system COG0732 Cluster_687574 V1222692 GROS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) COG0234 Cluster_824707 V1222696 COAA map00770,map01100 H pantothenic acid kinase COG1072 Cluster_534424 V1222697 GLYA map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01230 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) COG0112 Cluster_370342 V1222701 S Metal dependent hydrolase COG2220 Cluster_408832 V1222704 S copper amine 121X1 Cluster_380570 V1222705 BCCA map00061,map01100 I carboxylase COG4770 Cluster_482673 V1222708 METX map00270,map00920,map01100 E Homoserine O-trans-acetylase COG2021 Cluster_762263 V1222709 NANE map00520 G Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) COG3010 Cluster_380571 V1222711 HUTU map00340,map01100 E Urocanate hydratase COG2987 Cluster_442975 V1222714 V Type I restriction modification DNA specificity domain protein COG0732 Cluster_467201 V1222716 LPD map00010,map00020,map00260,map00280,map00620,map01100,map01110,map01120 C dihydrolipoyl dehydrogenase COG1249 Cluster_458872 V1222717 AFTA M Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases 0Z57H Cluster_341018 V1222718 S NA 101UU Cluster_460912 V1222719 L Transposase COG3666 Cluster_438982 V1222722 RIMP S Required for maturation of 30S ribosomal subunits (By similarity) COG0779 Cluster_674167 V1222724 P Divalent cation transporter COG2239 Cluster_341019 V1222726 S NA 11NI8 Cluster_473604 V1222731 SCLAV_4397 S Domain of unknown function (DUF955) 0XUKG Cluster_342537 V1222732 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_454967 V1222733 PLSY map00561,map00564,map01100 S Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) COG0344 Cluster_599623 V1222735 PQQL O Peptidase, M16 COG0612 Cluster_492126 V1222736 BL01323 M Cell wall binding repeat 2-containing protein 0ZKZU Cluster_342538 V1222737 UVRA map03420 L Excinuclease abc subunit a COG0178 Cluster_342539 V1222738 S Inherit from NOG: Ribosomal protein 1272F Cluster_342540 V1222739 V Inherit from COG: Restriction modification system DNA (Specificity COG0286 Cluster_342541 V1222740 S Protein of unknown function (DUF2786) 1229N Cluster_342542 V1222741 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_342543 V1222742 PBPA map00550 M penicillin-binding protein COG0768 Cluster_342544 V1222744 INV1 M NLP P60 protein COG0791 Cluster_382340 V1222745 FADD4 map00071,map01100,map03320,map04146,map04920 Q Amp-dependent synthetase and ligase COG0318 Cluster_427103 V1222746 L Helicase COG4581 Cluster_718215 V1222747 S NA 126GF Cluster_444952 V1222748 L CT1975-like protein 0YBWR Cluster_342545 V1222749 HRPA L ATP-dependent helicase COG1643 Cluster_879963 V1222750 RIMO J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) COG0621 Cluster_344123 V1222755 L Dna topoisomerase COG0550 Cluster_344124 V1222756 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_344126 V1222758 YLBB V abc transporter permease protein COG0577 Cluster_345748 V1222759 FTSI map00550,map01100 M penicillin-binding protein COG0768 Cluster_585949 V1222760 RFBD map00521,map00523,map01100,map01110 M Dtdp-4-dehydrorhamnose reductase COG1898 Cluster_344127 V1222762 MAQU_3187 L Integrase catalytic subunit COG4584 Cluster_361999 V1222763 MT3801 S glutamate--cysteine ligase 0XP45 Cluster_344128 V1222764 S peptidase C10 11SDT Cluster_446998 V1222766 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_512463 V1222768 S conserved domain protein 11RSW Cluster_477949 V1222769 HISC map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01230 E imidazole acetol-phosphate transaminase COG0079 Cluster_419726 V1222770 NIRA map00910,map00920,map01100,map01120 C Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) COG0155 Cluster_754978 V1222772 YCEI S ycei family COG2353 Cluster_344130 V1222774 OPPB1 P Binding-protein-dependent transport systems inner membrane component COG0601 Cluster_517843 V1222775 GLUQ map00860,map00970,map01100,map01110 J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) COG0008 Cluster_724892 V1222776 S Membrane COG1738 Cluster_543011 V1222777 NADD map00230,map00760,map01100,map05340 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) COG1057 Cluster_800911 V1222778 RSFS S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) COG0799 Cluster_489631 V1222779 RLMH S Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) COG1576 Cluster_632876 V1222781 V Abi-like protein COG4823 Cluster_345749 V1222784 L transposase COG3328 Cluster_345750 V1222789 M phosphoglycerol transferase COG1368 Cluster_596106 V1222790 map02010 P ABC transporter COG1122 Cluster_345751 V1222793 C L-carnitine dehydratase bile acid-inducible protein F COG1804 Cluster_345752 V1222794 CAPA M Capsule synthesis protein COG2843 Cluster_345753 V1222795 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_683138 V1222798 SELA map00450,map00970 E Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) COG1921 Cluster_392967 V1222799 PEPN map00480,map01100 E Pfam:DUF3358 COG0308 Cluster_347336 V1222800 M domain protein COG4932 Cluster_855546 V1222803 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_440965 V1222804 SUFC O feS assembly ATPase SufC COG0396 Cluster_748103 V1222805 NDH map00190 C NADH dehydrogenase COG1252 Cluster_621546 V1222806 CFA M cyclopropane-fatty-acyl-phospholipid synthase COG2230 Cluster_494610 V1222807 CSAB M Polysaccharide pyruvyl transferase COG2327 Cluster_440966 V1222810 CCA map03013,map03018 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate COG0617 Cluster_502311 V1222811 LGAS_0604 V Hnh endonuclease 0XUCJ Cluster_484998 V1222813 YDCQ D ftsk SpoIIIE family protein COG1674 Cluster_350562 V1222814 AFTA M Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases 0Z57H Cluster_348946 V1222815 V ABC transporter, ATP-binding protein COG1132 Cluster_347337 V1222816 PRFA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) COG0216 Cluster_347338 V1222817 SSDA map00250,map00350,map00650,map01100,map01120 C Dehydrogenase COG1012 Cluster_348947 V1222822 V restriction COG1401 Cluster_348948 V1222823 PDXP G hydrolase COG0647 Cluster_348949 V1222824 BCRA map02010 V ABC transporter COG1131 Cluster_363567 V1222826 RHTA S Membrane COG5006 Cluster_442976 V1222827 S NA 0Y5S9 Cluster_549005 V1222828 SAGG map02010 V ABC transporter, ATP-binding protein COG1131 Cluster_348950 V1222830 L DNA mismatch repair protein COG0323 Cluster_754979 V1222832 SP_2027 S MORN repeat protein COG4642 Cluster_509882 V1222834 SCLAV_1000 S TPR-repeat-containing protein 10GX4 Cluster_551909 V1222836 S 5'-phosphate oxidase COG3576 Cluster_796968 V1222837 FADE36_1 S Aminoglycoside phosphotransferase COG3173 Cluster_762264 V1222838 S Protein of unknown function (DUF3408) 11QAR Cluster_892148 V1222839 S NA 11TBU Cluster_467203 V1222840 REPW S Plasmid Encoded RepA Protein 0XSQ6 Cluster_545948 V1222841 T Protein tyrosine phosphatase COG0394 Cluster_348951 V1222843 U, W Pfam:HIM COG5295 Cluster_350563 V1222845 ACCC map00061,map00253,map00620,map00640,map00720,map01100,map01110,map01120 I acetyl-CoA carboxylase biotin carboxylase COG0439 Cluster_350564 V1222848 TNP7109-31 L Transposase COG3328 Cluster_695918 V1222850 GBS0384 S NA 0Y5Y1 Cluster_350565 V1222851 PPGK map00010,map00520,map01100,map01110,map01120 G Polyphosphate glucokinase COG1940 Cluster_545950 V1222852 DPPD map02010 E, P (ABC) transporter COG0444 Cluster_702269 V1222853 OPPC P Binding-protein-dependent transport systems inner membrane component COG1173 Cluster_378836 V1222854 PCKG map00010,map00020,map00620,map01100,map01110,map01120,map03320,map04151,map04910,map04920,map04964 C Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) COG1274 Cluster_543012 V1222856 S NA 117XY Cluster_800912 V1222857 ALBF P drug resistance transporter, EmrB QacA subfamily 0XNN3 Cluster_463037 V1222858 YBEY S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) COG0319 Cluster_350567 V1222860 TGT J Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COG0343 Cluster_734689 V1222861 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_661283 V1222863 S Uncharacterized conserved protein (DUF2163) COG5449 Cluster_576421 V1222864 S Conserved hypothetical protein 2217 (DUF2460) 0YITT Cluster_705363 V1222867 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii subunits gamma and tau COG2812 Cluster_442977 V1222868 MT3314 I diacylglycerol kinase, catalytic region COG1597 Cluster_352063 V1222869 map00910 S 2-Nitropropane dioxygenase COG2070 Cluster_785233 V1222871 S Membrane COG3949 Cluster_531641 V1222872 S NA 0ZX6K Cluster_412501 V1222874 MT3758 U Type ii secretion system COG4965 Cluster_352065 V1222875 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_450989 V1222881 BMUL_5125 S UPF0317 protein COG4336 Cluster_566907 V1222884 YCHM P sulfate transporter COG0659 Cluster_377061 V1222887 FTSP D Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) COG2132 Cluster_352066 V1222888 S NA 0ZN4K Cluster_352067 V1222890 GYRA L DNA gyrase subunit a COG1372 Cluster_769969 V1222892 OTSB map00500,map01100 G K01087 trehalose 6-phosphate phosphatase EC 3.1.3.12 COG1877 Cluster_370343 V1222894 TIG O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COG0544 Cluster_353729 V1222895 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_370344 V1222897 L transposase, IS605 OrfB COG0675 Cluster_632877 V1222898 FEUA map02010 P abc transporter atp-binding protein COG4604 Cluster_603187 V1222899 FATC map02010 P permease protein COG4605 Cluster_863881 V1222900 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_452935 V1222901 S NA 0YWA6 Cluster_425171 V1222903 ATPF map00190,map00195,map01100 C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) COG0711 Cluster_353731 V1222906 GALE map00052,map00520,map01100,map01110 M udp-glucose 4-epimerase COG1087 Cluster_738023 V1222907 U, W Pfam:YadA COG5295 Cluster_579527 V1222908 U, W Pfam:YadA COG5295 Cluster_353732 V1222910 map00500,map01100,map01110 G, M phosphorylase COG0438 Cluster_377062 V1222911 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_617878 V1222914 PCNB map03013,map03018 J polymerase COG0617 Cluster_614116 V1222915 RV0038 K UPF0301 protein COG1678 Cluster_355403 V1222916 V FtsX-like permease family COG0577 Cluster_353733 V1222917 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120 G phosphohexose isomerase COG0166 Cluster_355404 V1222919 FEOB P Ferrous iron transport protein B COG0370 Cluster_417954 V1222921 V Restriction modification system DNA (Specificity COG0732 Cluster_444953 V1222923 M Cell surface protein 11GRZ Cluster_859549 V1222924 map00052,map00520,map01100,map01110 G, M Inherit from COG: Nad-dependent epimerase dehydratase COG0451 Cluster_734690 V1222926 RES V Type III COG3587 Cluster_569984 V1222928 MSRA O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) COG0225 Cluster_384112 V1222931 METQ map02010 P lipoprotein COG1464 Cluster_507292 V1222932 SPOU map00340,map00350,map00624,map01120 J tRNA rRNA methyltransferase COG0566 Cluster_867889 V1222933 G Glycoside hydrolase family 76 COG4833 Cluster_589269 V1222935 BIRA map00780,map01100 H biotin acetyl-CoA-carboxylase ligase COG0340 Cluster_475741 V1222937 P tonB-dependent Receptor 0XPDR Cluster_469346 V1222938 PPHA_0614 L transposase COG3335 Cluster_473605 V1222945 BCOA_0505 L transposase COG0675 Cluster_357092 V1222948 MUTS2 L DNA mismatch repair protein COG0249 Cluster_357093 V1222952 THIJ S intracellular protease Pfpi family COG0693 Cluster_512464 V1222953 SG1639 S Phage-Associated Protein COG3600 Cluster_585950 V1222956 M NA 0ZP9N Cluster_357094 V1222957 YGAD map02010 V ABC transporter COG1132 Cluster_781108 V1222958 M Inherit from NOG: Polymorphic outer membrane protein 11KKP Cluster_636904 V1222961 TPDA E peptidase COG0624 Cluster_904904 V1222962 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_358766 V1222963 AROB map00230,map00400,map01100,map01110,map01230 E 3-dehydroquinate synthase COG0337 Cluster_358767 V1222964 GLYA map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01230 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) COG0112 Cluster_380572 V1222965 U35 S ATP-dependent Clp protease, proteolytic subunit 0XZ09 Cluster_382341 V1222966 YBGL E lamb ycsf family protein COG1540 Cluster_358768 V1222967 YXBA S ATP-grasp COG3919 Cluster_367024 V1222968 C FMN-binding domain protein COG3976 Cluster_695919 V1222969 MURE map00300,map00550 M mur ligase COG0769 Cluster_365309 V1222970 S Conserved Protein COG4804 Cluster_520390 V1222971 LTRA L reverse transcriptase COG3344 Cluster_520391 V1222973 SCLAV_2340 K Transcriptional regulator 11HTM Cluster_695920 V1222974 M Glycosyl transferase COG0463 Cluster_360431 V1222975 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_398282 V1222976 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_360432 V1222978 VIRB11 map03070,map05120 U type IV secretion system COG0630 Cluster_507293 V1222979 K transcriptional regulator COG1737 Cluster_360433 V1222980 V ABC transporter, permease COG0577 Cluster_362000 V1222981 PGLE E DegT DnrJ EryC1 StrS aminotransferase COG0399 Cluster_360434 V1222984 FADA2 map00071,map00072,map00280,map00281,map00310,map00350,map00362,map00380,map00592,map00620,map00627,map00630,map00640,map00642,map00650,map00720,map00900,map00903,map01100,map01110,map01120,map02020 I Acetyl-COA acetyltransferase COG0183 Cluster_412503 V1222985 LIPA map00785,map01100 H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) COG0320 Cluster_360435 V1222986 U, W Inherit from COG: domain protein COG5295 Cluster_449024 V1222987 HISC map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01230 E May catalyze the transamination reaction in phenylalanine biosynthesis (By similarity) COG0079 Cluster_867890 V1222988 G transporter 0XP7I Cluster_789230 V1222992 L DNA Methylase COG2189 Cluster_362001 V1222995 V abc transporter permease protein 0ZW5X Cluster_785234 V1222996 DCUC C C4-dicarboxylate transporter COG3069 Cluster_360436 V1222998 MURE map00300,map00550 M mur ligase COG0769 Cluster_362002 V1222999 AZL_008490 L DNA methylase COG0863 Cluster_484999 V1223000 U Biopolymer transport protein exbD tolR 11GVS Cluster_362003 V1223003 S Cell surface-anchored protein 1005T Cluster_362004 V1223004 ESSC D ftsk spoIIIe COG1674 Cluster_492127 V1223006 PECS K Transcriptional regulator 11Q21 Cluster_734691 V1223007 ISPF map00900,map01100,map01110 I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) COG0245 Cluster_579528 V1223008 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_385884 V1223009 S P22 coat protein - gene protein 5 11FX2 Cluster_394779 V1223011 DING L helicase COG1199 Cluster_362005 V1223012 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_820722 V1223013 K Transcriptional regulator, ARAC family 125DJ Cluster_432983 V1223015 FAHA Q 5-carboxymethyl-2-hydroxymuconate Delta-isomerase (EC 5.3.3.10) COG0179 Cluster_363568 V1223017 U, W Pfam:YadA COG5295 Cluster_362006 V1223018 CYDC map02010 P ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC COG1132 Cluster_436954 V1223019 L Integrase core domain protein COG2801 Cluster_785235 V1223020 FBPA K Fibronectin-binding protein COG1293 Cluster_363569 V1223022 DPEP_1224 C Ferredoxin COG3894 Cluster_475742 V1223023 WHIA K May be required for sporulation (By similarity) COG1481 Cluster_365310 V1223024 LYTR2 K TRANSCRIPTIONal COG1316 Cluster_363570 V1223025 S NA 12BRW Cluster_363571 V1223026 PRPC map00020,map00630,map00640,map01100,map01110,map01120,map01210,map01230 C citrate synthase COG0372 Cluster_363573 V1223028 PKNA T serine threonine protein kinase COG0515 Cluster_509883 V1223029 SMPB O Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) COG0691 Cluster_809145 V1223030 I, Q Short chain dehydrogenase COG1028 Cluster_828535 V1223031 PTSG map00010,map00500,map00520,map02060 G PTS system COG2190 Cluster_543013 V1223034 S Protein of unknown function (DUF3152) 10F95 Cluster_398283 V1223035 V N-6 DNA Methylase COG0286 Cluster_582768 V1223038 PURC map00230,map01100,map01110 F SAICAR synthetase COG0152 Cluster_913219 V1223041 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_434897 V1223042 S NA 0YR6I Cluster_554773 V1223045 TRPB map00260,map00400,map01100,map01110,map01230 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) COG0133 Cluster_375292 V1223047 RPLC map03010 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 Cluster_365312 V1223048 L DNA polymerase 0XRUF Cluster_657055 V1223051 TRML map04122 J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) COG0219 Cluster_644797 V1223052 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_492128 V1223053 RECX S Modulates RecA activity (By similarity) COG2137 Cluster_596107 V1223056 PDXY map00750,map01100 H functions in a salvage pathway. Uses pyridoxamine (By similarity) COG2240 Cluster_758502 V1223057 map02010 E Extracellular solute-binding protein, family 5 COG0747 Cluster_526083 V1223058 P ABC transporter, permease COG0601 Cluster_394780 V1223059 GK0308 L Transposase COG3464 Cluster_365314 V1223060 NPSC Q amino acid adenylation domain protein COG1020 Cluster_434898 V1223061 IUNH map00230,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_367025 V1223062 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_526084 V1223063 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_367026 V1223064 HEMD map00860,map01100,map01110 H synthase COG1587 Cluster_625331 V1223065 L helicase domain protein COG0553 Cluster_610463 V1223067 Y0354 O Glutamine cyclotransferase COG3823 Cluster_378837 V1223068 PHOH T Phoh family COG1702 Cluster_394781 V1223069 GLXR map02020,map05111 T transcriptional regulator, crp fnr family COG0664 Cluster_425172 V1223070 SDHA map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020,map05134 C succinate dehydrogenase, flavoprotein subunit COG1053 Cluster_475743 V1223072 S radical SAM domain protein COG4277 Cluster_515168 V1223073 DAM map03430 L Dna adenine methylase COG0338 Cluster_728160 V1223074 ATPD map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG1394 Cluster_367027 V1223075 S copper amine 0XP8R Cluster_401796 V1223076 S Dehydrogenase reductase COG0300 Cluster_560755 V1223077 V HNHc 125G9 Cluster_748104 V1223078 SSCG_05367 J acetyltransferase COG1670 Cluster_557688 V1223082 C NADH:flavin oxidoreductase / NADH oxidase family COG1902 Cluster_367028 V1223083 S NA 11NI8 Cluster_454968 V1223085 PROA map00330,map01100,map01230 E Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) COG0014 Cluster_412504 V1223087 HTAA S domain protein 11Z68 Cluster_367029 V1223088 M Cell wall anchor domain protein 129AF Cluster_367030 V1223091 SURB S G5 domain protein 0ZVV3 Cluster_368631 V1223092 map00540,map01100 M lipid A biosynthesis COG1560 Cluster_408833 V1223094 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_367031 V1223095 S SusD family 0YEUD Cluster_606803 V1223097 S dNA-binding protein 12AGK Cluster_367032 V1223098 M peptidase COG0791 Cluster_705364 V1223100 S Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily 11QNP Cluster_368632 V1223101 SURB S G5 domain protein 0ZVV3 Cluster_368633 V1223102 HSDM V type I restriction-modification system, M subunit COG0286 Cluster_368634 V1223106 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_449025 V1223107 S integral membrane protein COG0628 Cluster_368635 V1223108 YJJK S ABC transporter, ATP-binding protein COG0488 Cluster_636905 V1223109 LICD3 M licD family COG3475 Cluster_414372 V1223111 S NA 11MTE Cluster_475744 V1223112 ALKA map03410 L 8-oxoguanine DNA glycosylase COG0122 Cluster_855547 V1223113 SRTB U sortase, SrtB family COG4509 Cluster_398284 V1223115 S NA 11PGB Cluster_370345 V1223116 GK0308 L Transposase COG3464 Cluster_403575 V1223117 PEPDA E Dipeptidase COG4690 Cluster_368637 V1223118 LCOP P Transporter COG1292 Cluster_368638 V1223119 THRC map00260,map00750,map01100,map01120,map01230 E threonine synthase COG0498 Cluster_477950 V1223122 S NA 0Y87T Cluster_824708 V1223123 S NA 11IN7 Cluster_621547 V1223125 YHCF K TRANSCRIPTIONAl REGULATOR GntR family COG1725 Cluster_368639 V1223127 map05132 M repeat protein COG3209 Cluster_370347 V1223128 RODA map00550,map04112 D cell cycle protein COG0772 Cluster_389424 V1223129 GLPQ map00564 C glycerophosphoryl diester phosphodiesterase COG0584 Cluster_526085 V1223136 UREE O Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) COG2371 Cluster_371961 V1223140 PURB map00230,map00250,map01100,map01110 F Adenylosuccinate lyase COG0015 Cluster_460913 V1223141 PBP2B M penicillin-binding protein COG0768 Cluster_371963 V1223151 MRCB map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_370351 V1223152 S Rib/alpha-like repeat 10008 Cluster_563708 V1223156 map02010 G, M ABC transporter COG1134 Cluster_371964 V1223158 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_576423 V1223161 HMUO map00860,map04978 P Heme oxygenase COG5398 Cluster_554774 V1223164 RV0049 S NA 11WJF Cluster_373575 V1223168 FEPC2 map02010 P ABC transporter COG1120 Cluster_371965 V1223169 SULP P sulfate transporter COG0659 Cluster_373576 V1223171 CNA M domain protein 0ZWTG Cluster_373577 V1223172 PUTA map00250,map00330,map01100,map01110 C Dehydrogenase COG1012 Cluster_687575 V1223175 ARTH_4141 map00620 C d-lactate dehydrogenase COG0277 Cluster_678609 V1223176 S ABC transporter COG4152 Cluster_380573 V1223177 S NA 11ZCV Cluster_373580 V1223182 RMLB map00521,map00523,map01055,map01100,map01110 M dtdp-glucose 4,6-dehydratase COG1088 Cluster_375293 V1223183 map00071,map03320,map04146,map04920 S carnitine O-acetyltransferase EC 2.3.1.7 0XNZ9 Cluster_373582 V1223185 S NA 0ZHVH Cluster_373583 V1223186 METN map02010 P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COG1135 Cluster_621548 V1223187 S NA 0ZHU9 Cluster_702273 V1223188 MRA_3235 O glutaredoxin-like protein COG0695 Cluster_373584 V1223189 MGT map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_375294 V1223192 GLMU map00520,map01100,map01110 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) COG1207 Cluster_526086 V1223193 S HutP family 11NY2 Cluster_375295 V1223194 SFUB map02010 P transporter (permease) COG1178 Cluster_373585 V1223195 S Domain of unknown function (DUF222) 0ZBYA Cluster_375297 V1223197 GLFT M Transferase COG1216 Cluster_375298 V1223198 RGPE M Glycosyl transferase (Group 1 0XTCA Cluster_416150 V1223199 S NA 0ZHU9 Cluster_714972 V1223201 OTSB map00500,map01100 G K01087 trehalose 6-phosphate phosphatase EC 3.1.3.12 COG1877 Cluster_563709 V1223202 Q Inherit from COG: depolymerase COG3509 Cluster_449026 V1223204 GLTT E glutamate COG0786 Cluster_375299 V1223205 NPSC Q amino acid adenylation domain protein COG1020 Cluster_377063 V1223208 P TonB-dependent receptor Plug COG4771 Cluster_549006 V1223209 O Osmc-like protein 11ZZ5 Cluster_661285 V1223210 YABA S Involved in initiation control of chromosome replication (By similarity) COG4467 Cluster_480359 V1223212 G Major Facilitator superfamily 11Q79 Cluster_762267 V1223213 S Protein of unknown function (DUF2550) 0ZXR0 Cluster_734693 V1223214 ATPC map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG0355 Cluster_377064 V1223215 NHAC-1 map00680 C Na H antiporter COG1757 Cluster_785237 V1223218 YKKB map00350,map00362,map00627,map00642,map00903,map01120 J gCN5-related N-acetyltransferase COG1670 Cluster_669767 V1223219 S NA 11GVV Cluster_377065 V1223220 S NA 0Y9TN Cluster_380574 V1223221 OCAR_6158 L Terminase, large subunit COG4626 Cluster_475745 V1223222 S NA 0XTEF Cluster_375300 V1223223 LIPS2 map00561,map01100 S Secretory lipase 0YTM1 Cluster_377066 V1223225 S Tetratricopeptide tpr_2 repeat protein 16RZF@proNOG Cluster_377067 V1223226 UVRA map03420 L Excinuclease abc subunit a COG0178 Cluster_502313 V1223229 YQEY S gatB Yqey COG1610 Cluster_497117 V1223230 S lysozyme 0YC6U Cluster_531642 V1223231 BL00983 S Phage Portal Protein 11QNG Cluster_537322 V1223233 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_721546 V1223234 PANB map00770,map01100,map01110 H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) COG0413 Cluster_400008 V1223235 B565_1256 S NA 11JBM Cluster_816915 V1223236 COMM O Mg chelatase subunit ChlI COG0606 Cluster_582769 V1223237 SCLAV_4550 L UPF0102 protein COG0792 Cluster_377068 V1223239 S SPP1 gp7 family 12A6V Cluster_377069 V1223240 U, W Domain-Containing protein COG5295 Cluster_475746 V1223242 V ABC transporter COG1131 Cluster_683142 V1223245 SCLAV_3320 J 2'-5' rna ligase COG1514 Cluster_617879 V1223246 HRPB L ATP-dependent helicase COG1643 Cluster_378838 V1223247 SPR M NlpC p60 family protein COG0791 Cluster_416151 V1223248 S NA 0YKKJ Cluster_458873 V1223249 SP_0341 S UPF0371 protein COG4868 Cluster_458874 V1223251 MNTB map02010 P (ABC) transporter COG1121 Cluster_734694 V1223253 M Cell wall anchor domain protein 11Q8J Cluster_378840 V1223254 PEPN map00480,map01100 E aminopeptidase N COG0308 Cluster_378841 V1223255 S NA 11FYY Cluster_378842 V1223256 S conserved domain protein 11Q3F Cluster_378843 V1223257 S Inherit from COG: endonuclease exonuclease phosphatase COG4222 Cluster_644798 V1223258 RLUB J pseudouridine synthase COG1187 Cluster_378844 V1223259 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_800914 V1223260 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_557690 V1223261 DUSB J Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_721547 V1223264 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_378845 V1223265 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_380576 V1223266 S NA 0XQBQ Cluster_840015 V1223267 ZUPT P Mediates zinc uptake. May also transport other divalent cations (By similarity) COG0428 Cluster_412505 V1223268 TRMD map00900,map01100,map01110 J Specifically methylates guanosine-37 in various tRNAs (By similarity) COG0336 Cluster_859550 V1223271 ILVA map00260,map00290,map01100,map01110,map01230 E Threonine dehydratase COG1171 Cluster_477951 V1223273 GCA map00350,map00362,map00627,map00642,map00903,map01120 L Transferase COG0663 Cluster_458875 V1223276 V type II restriction enzyme, methylase subunit COG1002 Cluster_384113 V1223283 S NA 177T9@proNOG Cluster_396561 V1223284 RV0191 G integral membrane protein COG2814 Cluster_824710 V1223286 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_644799 V1223287 RPMA map03010 J 50S ribosomal protein l27 COG0211 Cluster_430975 V1223288 RPMA map03010 J 50S ribosomal protein l27 COG0211 Cluster_385885 V1223289 YTFP S hi0933 family COG2081 Cluster_557691 V1223291 TPDA E peptidase COG0624 Cluster_531643 V1223292 S Secreted protein 11J24 Cluster_382342 V1223296 AROP E amino acid COG1113 Cluster_382343 V1223297 CYSD map00230,map00450,map00920,map01100,map01120 P sulfate adenylyltransferase), subunit 2 COG0175 Cluster_382344 V1223303 MT0057 S integral membrane protein COG5650 Cluster_460915 V1223304 FTSK D cell division protein FtsK COG1674 Cluster_382345 V1223305 PRPD map00640 S 2-methylcitrate dehydratase COG2079 Cluster_396562 V1223306 S Conjugative transposon TraN protein 0XNQ2 Cluster_382346 V1223307 HCP C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) COG1151 Cluster_657056 V1223308 S sigma-70, region 4 11JJM Cluster_382347 V1223309 S NA 1212E Cluster_469348 V1223310 S NA 0ZK9J Cluster_452936 V1223312 METE map00270,map00450,map01100,map01110,map01230 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) COG0620 Cluster_789233 V1223313 DACET_1463 S DNA-binding protein COG3943 Cluster_502314 V1223314 S Putative ATPase subunit of terminase (gpP-like) 0Z1RP Cluster_382348 V1223315 S NA 101UU Cluster_579529 V1223316 SUN_0728 L transposase (IS4 family) protein 12CNV Cluster_414373 V1223317 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_382349 V1223318 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_384114 V1223320 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_384115 V1223321 LMRA V Abc transporter COG1132 Cluster_596108 V1223322 LIN2373 V Abortive infection bacteriophage resistance protein COG4823 Cluster_400009 V1223323 RRMA Q Methyltransferase COG0500 Cluster_526087 V1223325 PPIB O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) COG0652 Cluster_384116 V1223327 S NA 11NI8 Cluster_796971 V1223329 YQEY S gatB Yqey COG1610 Cluster_551910 V1223330 MT3785 S metallophosphoesterase COG1408 Cluster_384117 V1223331 TETB map02010 V ABC transporter COG1132 Cluster_603188 V1223332 DCP E oligopeptidase A COG0339 Cluster_384118 V1223333 PUUR K Transcriptional regulator COG1396 Cluster_384119 V1223334 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_674168 V1223335 SCLAV_3863 S Membrane 0XVS8 Cluster_805108 V1223336 MCA S mycothiol conjugate amidase mca COG2120 Cluster_692101 V1223337 LIPT map00363,map00960,map01120 I Carboxylesterase COG2272 Cluster_384120 V1223343 HELY L helicase COG4581 Cluster_384121 V1223344 S tonB-dependent Receptor 0YAYV Cluster_385886 V1223346 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_425173 V1223348 ADHE2 map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map05204 C Dehydrogenase COG1062 Cluster_777363 V1223350 GBS0386 S domain protein 0XRRR Cluster_385887 V1223354 HRPA L ATP-dependent helicase COG1643 Cluster_385888 V1223356 DPNA L helicase COG4646 Cluster_385889 V1223357 SURB S G5 domain protein 0ZVV3 Cluster_385890 V1223358 S Phage portal protein, SPP1 Gp6-like 0XRSA Cluster_385891 V1223359 S Putative esterase COG0627 Cluster_417955 V1223360 MAG map03410 L 3-methyladenine DNA glycosylase COG2094 Cluster_387722 V1223361 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_592624 V1223363 M Efflux transporter, RND family, MFP subunit 0XNVN Cluster_460916 V1223365 S NA 0ZZZK Cluster_385892 V1223369 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_387723 V1223373 O Heat shock protein COG0443 Cluster_387724 V1223374 L Transposase, IS605 OrfB family 0XT7Q Cluster_796973 V1223376 L DNA binding domain protein, excisionase family 121NU Cluster_387725 V1223377 SSCG_01435 E ABC transporter COG0765 Cluster_387726 V1223378 YFMR S abc transporter COG0488 Cluster_820724 V1223379 YNIA map00564,map01100 G Fructosamine kinase COG3001 Cluster_657057 V1223381 L Pfam:Transposase_8 12BD7 Cluster_892149 V1223382 RBFA J Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) COG0858 Cluster_463039 V1223383 NRNA J phosphoesterase RecJ domain protein COG0618 Cluster_526088 V1223384 K Prophage LambdaCh01, transcriptional regulator 123FJ Cluster_387727 V1223386 CSHA map03018 L atp-dependent rna helicase COG0513 Cluster_485000 V1223387 S membrane 11PB2 Cluster_851768 V1223392 MCBR K Transcriptional regulator 11WG2 Cluster_450990 V1223394 YBGL E lamb ycsf family protein COG1540 Cluster_387728 V1223396 S peptidase 0XPBV Cluster_387729 V1223398 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_400010 V1223399 S zeta toxin 11J1Q Cluster_758503 V1223402 map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_781111 V1223404 T response regulator COG2197 Cluster_699192 V1223405 S NA 11M4I Cluster_699193 V1223409 FADD map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG0318 Cluster_824711 V1223410 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_389426 V1223411 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_421525 V1223412 SP_2234 K Transcriptional regulator, TetR family COG1309 Cluster_573200 V1223413 S Beta-lactamase domain protein COG0491 Cluster_867893 V1223415 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_540132 V1223416 ARGC map00330,map01100,map01110,map01210,map01230 E N-acetylglutamate semialdehyde dehydrogenase COG0002 Cluster_389427 V1223418 AROA map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate synthase COG0128 Cluster_449027 V1223419 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_492129 V1223421 AROK map00400,map01100,map01110,map01230 E Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) COG0703 Cluster_447000 V1223423 map02010 E Abc transporter COG0410 Cluster_731474 V1223424 S Bacterial protein of unknown function (DUF896) COG4224 Cluster_391152 V1223428 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_456900 V1223430 VIUB P Siderophore-interacting protein COG2375 Cluster_391153 V1223431 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_391154 V1223432 PROY E amino acid COG1113 Cluster_447001 V1223436 CCMA map02010 V (ABC) transporter COG1131 Cluster_731475 V1223437 S NA 0ZD0C Cluster_391155 V1223438 MRPA map00190 P monovalent cation H antiporter subunit A COG2111 Cluster_430976 V1223439 M hydrolase, family 25 COG3757 Cluster_391156 V1223440 CINA H competence damage-inducible protein COG1546 Cluster_554775 V1223441 MT1132 S NA 12B5W Cluster_391157 V1223443 FAS map00061,map01100 I fatty acid synthase COG4982 Cluster_471498 V1223445 S acetyltransferase, (GNAT) family COG3981 Cluster_741444 V1223447 GLTL map02010,map02020 E (ABC) transporter COG1126 Cluster_625333 V1223448 GLUB map02010,map02020 E, T Extracellular solute-binding protein family 3 COG0834 Cluster_629057 V1223450 FECD map02010 P permease protein COG0609 Cluster_392968 V1223451 SP_1245 S hydrolase COG0561 Cluster_392969 V1223454 SSCG_04100 S YibE F family protein COG5438 Cluster_391159 V1223455 ALDA map00010,map00040,map00053,map00071,map00280,map00281,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00626,map00640,map00903,map01100,map01110,map01120 C Aldehyde dehydrogenase family COG1012 Cluster_563710 V1223456 CG3417 L nudix hydrolase COG0494 Cluster_863886 V1223457 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_540133 V1223460 S integral membrane protein COG3182 Cluster_392970 V1223461 S Lpxtg-motif cell wall anchor domain protein 0XQBH Cluster_392971 V1223463 S NA 0YM2S Cluster_392972 V1223468 TNPB L integrase catalytic COG2801 Cluster_452938 V1223469 HTRB map00540,map01100 M lipid a biosynthesis lauroyl acyltransferase COG1560 Cluster_394782 V1223470 VIRB4 map03070,map05120 U conjugal transfer ATPase COG3451 Cluster_392973 V1223471 WECC map00051,map00363,map00520,map00591,map00625,map00650,map01100,map01120 M Dehydrogenase COG0677 Cluster_773640 V1223474 HEME map00860,map01100,map01110 H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) COG0407 Cluster_394783 V1223476 MT3058 S Secreted protein 11UJP Cluster_724894 V1223479 BCELL_1025 L Inherit from firmNOG: Transposase COG2801 Cluster_751521 V1223481 PHEA map00400,map01100,map01110,map01230 E Prephenate dehydratase COG0077 Cluster_632879 V1223482 S NA 0Y8RQ Cluster_731476 V1223483 REPA L Replication initiator protein A 0YDCP Cluster_394785 V1223484 PRFA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) COG0216 Cluster_394786 V1223486 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_477953 V1223489 O Pentapeptide repeat protein COG1357 Cluster_394787 V1223490 RECG map03440 L ATP-dependent DNA helicase recg COG1200 Cluster_394788 V1223491 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_702275 V1223496 RPLX map03010 J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) COG0198 Cluster_632880 V1223497 RPLE map03010 J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COG0094 Cluster_394790 V1223498 S phage terminase large subunit 0XPS1 Cluster_661286 V1223499 SERB map00260,map00680,map01100,map01120,map01230 E phosphoserine phosphatase COG3830 Cluster_394791 V1223500 YGEX map00260,map00290,map01100,map01110,map01230 E Diaminopropionate ammonia-lyase COG1171 Cluster_396563 V1223501 SDHA map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020,map05134 C succinate dehydrogenase, flavoprotein subunit COG1053 Cluster_603189 V1223502 O Inherit from COG: peptidase COG1026 Cluster_551912 V1223503 HSDS V type i restriction modification DNA specificity domain protein COG0732 Cluster_396564 V1223505 RBSC S abc transporter COG1079 Cluster_394792 V1223506 DOTL S NA 16TD2@proNOG Cluster_425174 V1223507 S NGG1p interacting factor 3 protein, NIF3 COG3323 Cluster_436955 V1223508 PHOR T Histidine kinase 0XNMH Cluster_467205 V1223509 INFC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) COG0290 Cluster_394793 V1223511 map03420,map03430 L helicase COG3973 Cluster_394794 V1223512 CSP M n-acetylmuramoyl-l-alanine amidase COG5479 Cluster_545953 V1223515 K Transcriptional regulator, TetR family 103AX Cluster_396566 V1223516 WBPC I Acyl-transferase COG1835 Cluster_492130 V1223518 POTC map02010 P putrescine abc transporter COG1177 Cluster_636907 V1223520 SUFB O FeS assembly protein SUFB COG0719 Cluster_396567 V1223521 K AraC Family Transcriptional Regulator COG2207 Cluster_526089 V1223523 E, G EamA-like transporter family COG0697 Cluster_731477 V1223524 WHIB1 K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) 11UDY Cluster_396568 V1223525 TNPB L transposase COG0675 Cluster_396569 V1223526 S NA 0ZEM9 Cluster_396570 V1223527 SCLAV_4880 map00500,map01100,map01110 G Glycogen debranching enzyme COG1523 Cluster_396571 V1223528 T cyclic nucleotide-binding domain protein COG0664 Cluster_625335 V1223529 PGM map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase COG0033 Cluster_523166 V1223536 RPLO map03010 J Binds to the 23S rRNA (By similarity) COG0200 Cluster_731478 V1223537 GUAD map00230,map01100 F, J Cmp dcmp deaminase zinc-binding COG0590 Cluster_674169 V1223538 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 Cluster_396572 V1223540 PKNB T Serine Threonine protein kinase COG2815 Cluster_398285 V1223542 YEDI S Inner membrane protein yedI COG2354 Cluster_465129 V1223544 L UvrD REP helicase COG0210 Cluster_465130 V1223547 S NA 0YY2Z Cluster_640938 V1223548 SSCG_01435 E ABC transporter COG0765 Cluster_708461 V1223549 PKND E ABC transporter substrate-binding protein COG0834 Cluster_398287 V1223550 PPC map00620,map00680,map00710,map00720,map01100,map01120 C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) COG2352 Cluster_497118 V1223551 S Membrane 123WC Cluster_398289 V1223553 RLMG J Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA (By similarity) COG2813 Cluster_777364 V1223554 S peptidase, S41 11FNN Cluster_398290 V1223556 S Rib/alpha-like repeat 10008 Cluster_423385 V1223557 S Short-chain dehydrogenase reductase sdr COG1028 Cluster_400011 V1223558 P tonB-dependent Receptor COG4206 Cluster_398291 V1223559 SCLAV_0672 P integral membrane protein COG1253 Cluster_400012 V1223560 M Inherit from NOG: Polymorphic outer membrane protein 11KKP Cluster_592625 V1223561 S NA 0YRPJ Cluster_475747 V1223563 PALG map02010 G Binding-protein-dependent transport systems inner membrane component COG0395 Cluster_400013 V1223564 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_851769 V1223565 UDGA map00040,map00053,map00500,map00520,map01100,map01110 M Udp-glucose 6-dehydrogenase COG1004 Cluster_728163 V1223566 DCD map00240,map01100 F deoxycytidine triphosphate deaminase COG0717 Cluster_661288 V1223567 MVAN_1090 L transposase, IS3 IS911 family protein 128FE Cluster_800917 V1223568 CSPA K Cold shock protein COG1278 Cluster_520392 V1223569 S NA 11HKV Cluster_398292 V1223572 S NA 0YUD0 Cluster_892151 V1223573 RPMH map03010 J 50S ribosomal protein l34 COG0230 Cluster_412506 V1223574 C nitrilase cyanide hydratase and apolipoprotein n-acyltransferase COG0388 Cluster_398293 V1223575 map03420,map03430 L helicase COG3973 Cluster_621549 V1223578 DCD map00240,map01100 F deoxycytidine triphosphate deaminase COG0717 Cluster_400015 V1223580 S NA 11M0W Cluster_543015 V1223583 L phage plasmid primase, p4 family COG3378 Cluster_400016 V1223584 ALST E amino acid carrier protein COG1115 Cluster_549008 V1223586 YBHK S UPF0052 protein COG0391 Cluster_492131 V1223587 S Beta-lactamase domain protein COG0491 Cluster_400017 V1223588 MDLA V ABC transporter, ATP-binding protein COG1132 Cluster_400018 V1223590 YHBW C Luciferase family COG2141 Cluster_432984 V1223591 S Conserved domain protein 0XZV4 Cluster_400019 V1223592 DEAD map03018 L atp-dependent rna helicase COG0513 Cluster_714974 V1223593 DCM map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_400020 V1223594 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_687578 V1223595 U, W Inherit from COG: domain protein COG5295 Cluster_400021 V1223596 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins COG0706 Cluster_551913 V1223597 TRXB map00240,map00450 O thioredoxin reductase COG0492 Cluster_738025 V1223598 LLDP C L-lactate COG1620 Cluster_718216 V1223599 YVFV map00630,map01100,map01110,map01120 C glycolate oxidase (iron-sulfur subunit) COG0247 Cluster_401797 V1223600 U, W Pfam:Hep_Hag COG5295 Cluster_820725 V1223601 HIT F, G Histidine triad (Hit) protein COG0537 Cluster_596109 V1223602 PGSA1 map00562,map00564,map01100,map04070 I Cdp-alcohol phosphatidyltransferase COG0558 Cluster_699194 V1223604 CAT1 map00281,map00620,map00626,map01110,map01120 C Transferase COG0427 Cluster_855550 V1223605 YBHF V ABC, transporter COG1131 Cluster_596110 V1223606 T response regulator 11FXM Cluster_610465 V1223607 E 2-hydroxyglutaryl-CoA dehydratase COG1775 Cluster_734695 V1223608 S NA 0Y843 Cluster_557692 V1223610 PURE map00230,map01100,map01110 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) COG0041 Cluster_400022 V1223611 HSDM V type I restriction-modification system COG0286 Cluster_452939 V1223612 PURB map00230,map00250,map01100,map01110 F Adenylosuccinate lyase COG0015 Cluster_401798 V1223615 YEEA V methylase COG1002 Cluster_456901 V1223617 ISPE map00900,map01100,map01110 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COG1947 Cluster_400023 V1223618 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_416152 V1223619 MEND map00130,map01100,map01110 H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) COG1165 Cluster_487272 V1223620 CDPW8_0140 S Protein of unknown function (DUF3644) 11FC8 Cluster_582771 V1223621 CWLM M n-acetylmuramoyl-l-alanine amidase COG3409 Cluster_828538 V1223622 TRXA O Thioredoxin COG0526 Cluster_401799 V1223623 TRPA map00260,map00400,map01100,map01110,map01230 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) COG0159 Cluster_400024 V1223624 M Pilin isopeptide linkage domain protein 11AV1 Cluster_401800 V1223625 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_401801 V1223630 MRCB map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_569985 V1223631 map02010 V ABC transporter COG1132 Cluster_401803 V1223634 COABC map00770,map01100 H Phosphopantothenoylcysteine decarboxylase COG0452 Cluster_621550 V1223636 PEPN map00480,map01100 E aminopeptidase N COG0308 Cluster_545954 V1223638 SCLAV_3679 S Alpha beta hydrolase fold COG0596 Cluster_480360 V1223639 STRIC_0432 L Transposase (IS4 family 11HCS Cluster_777366 V1223643 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_751522 V1223644 TSNR J rrna methyltransferase COG0566 Cluster_458877 V1223647 L helicase COG4581 Cluster_403576 V1223648 S basic membrane COG1744 Cluster_785240 V1223649 L integrase family 0XRS7 Cluster_610466 V1223650 S Domain of unknown function (DUF1896) 11Y7P Cluster_427104 V1223654 PPM1 map00510,map01100 M dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) 0XQRC Cluster_430977 V1223655 PURF map00230,map00250,map01100,map01110 F glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_403578 V1223658 ABGA E amidohydrolase COG1473 Cluster_711601 V1223659 S Protein of unknown function (DUF3618) 121IJ Cluster_724896 V1223661 CLPL O ATP-dependent Clp protease ATP-binding subunit COG0542 Cluster_754983 V1223665 S NA 1241G Cluster_718217 V1223667 YLBN S metal-binding protein COG1399 Cluster_683145 V1223668 RV2927C D growth COG3599 Cluster_403579 V1223669 ASTA S Arylsulfotransferase 174ZE@proNOG Cluster_403580 V1223670 S Frg domain protein 0ZXCB Cluster_403581 V1223672 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_403582 V1223673 GLTA map00020,map00630,map00640,map01100,map01110,map01120,map01210,map01230 C citrate synthase COG0372 Cluster_458878 V1223674 NAGB map00520,map01100,map01110 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COG0363 Cluster_403583 V1223675 DNAQ map03420,map03430 L Uvrd rep helicase COG2176 Cluster_444954 V1223678 S NA 11F3W Cluster_403584 V1223679 M NA 0YHI1 Cluster_403586 V1223685 MRPA map00190 P monovalent cation H antiporter subunit A COG2111 Cluster_405382 V1223686 SURB S G5 domain protein 0ZVV3 Cluster_405383 V1223687 HEMD map00860,map01100,map01110 H synthase COG1587 Cluster_403587 V1223688 MDLA V ABC transporter, ATP-binding protein COG1132 Cluster_405384 V1223689 GLTA map00020,map00630,map01100,map01110,map01120,map01210,map01230 C citrate synthase COG0372 Cluster_405385 V1223691 S NA 0Y8K6 Cluster_405386 V1223692 PRTP O peptidase S8 and S53, subtilisin, kexin, sedolisin COG2247 Cluster_405387 V1223693 CRTB map00906,map01062,map01100,map01110 I phytoene synthase COG1562 Cluster_405388 V1223694 PCKG map00010,map00020,map00620,map01100,map01110,map01120,map03320,map04151,map04910,map04920,map04964 C Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) COG1274 Cluster_449029 V1223695 TRPC map00400,map01100,map01110,map01230 E Indole-3-glycerol phosphate synthase COG0134 Cluster_504718 V1223696 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_417956 V1223699 MANA map00051,map00520,map01100,map01110 G mannose-6-phosphate isomerase COG1482 Cluster_606804 V1223701 ABGT H Transporter COG2978 Cluster_917564 V1223702 U TraG family COG3505 Cluster_692105 V1223705 CZRA K Transcriptional regulator, arsr family COG0640 Cluster_405390 V1223706 ALBF P drug resistance transporter, EmrB QacA subfamily 0XNN3 Cluster_405391 V1223707 S nlpC P60 family protein 0ZVM8 Cluster_789236 V1223708 XSEB map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1722 Cluster_405393 V1223711 ACEE map00010,map00020,map00620,map00650,map01100,map01110,map01120 C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) COG2609 Cluster_596111 V1223712 ARGJ map00330,map01100,map01110,map01210,map01230 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) COG1364 Cluster_824713 V1223713 ARGC map00330,map01100,map01110,map01210,map01230 E N-acetylglutamate semialdehyde dehydrogenase COG0002 Cluster_405394 V1223714 PRKC T serine threonine protein kinase COG0515 Cluster_405395 V1223715 V Type III COG3587 Cluster_758506 V1223716 GPT map00230,map01100,map01110 S phosphoribosyltransferase COG2236 Cluster_405397 V1223718 LVIS_1721 L transposase COG2826 Cluster_781112 V1223719 MT0376 S Protein of unknown function (DUF3151) 11W1H Cluster_751523 V1223720 S NA 0XSAP Cluster_405398 V1223721 O Tryp_SPc 0YAAN Cluster_751524 V1223723 RV0433 S ATP-dependent carboxylate-amine ligase (By similarity) COG2170 Cluster_405399 V1223725 CORA P magnesium and cobalt transport protein CorA COG0598 Cluster_617880 V1223726 RFE M Glycosyl transferase, family 4 COG0472 Cluster_762270 V1223727 SUA5 J sua5 ycio yrdc ywlc family protein COG0009 Cluster_614118 V1223730 S ragb susd domaiN-containing protein 0XP53 Cluster_405400 V1223732 PURM map00230,map01100,map01110 F phosphoribosylaminoimidazole synthetase COG0150 Cluster_407069 V1223733 DAGA E amino acid carrier protein COG1115 Cluster_708463 V1223735 YQEY S gatB Yqey COG1610 Cluster_625336 V1223738 CCEL_3034 S NA 0XYGI Cluster_405401 V1223740 AGCS map02020 E amino acid carrier protein COG1115 Cluster_557693 V1223744 S NA 0ZX1V Cluster_785241 V1223745 S NA 0ZX1V Cluster_554776 V1223749 BUDA map00650,map00660 Q Alpha-acetolactate decarboxylase COG3527 Cluster_482677 V1223750 RGPA M Glycosyl transferase (Group 1 0XPWD Cluster_417957 V1223753 S Membrane COG2311 Cluster_534427 V1223754 K transcriptional regulator COG1396 Cluster_585952 V1223755 CMTA S Trehalose corynomycolyl transferase COG0627 Cluster_460918 V1223761 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_475748 V1223762 S QueT transporter 11NXZ Cluster_610467 V1223763 S NA 1225K Cluster_407070 V1223766 L UvrD REP helicase COG0210 Cluster_407071 V1223767 M Cna protein B-type domain 0ZN11 Cluster_444955 V1223769 S Abortive infection protein AbiGII 0XQHH Cluster_408837 V1223770 YQEB O Selenium-dependent molybdenum hydroxylase system protein, YqeB family COG1975 Cluster_589271 V1223771 E, G permease COG0697 Cluster_517845 V1223772 K GntR Family Transcriptional Regulator COG1802 Cluster_450991 V1223773 MMPL H MMPL domain protein COG2409 Cluster_517846 V1223774 ELAA S gCN5-related N-acetyltransferase COG2153 Cluster_781113 V1223775 WECB map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_724898 V1223776 MT2407 S NA 124CH Cluster_408838 V1223777 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_408839 V1223779 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG1754 Cluster_417959 V1223780 RPOD map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_408840 V1223781 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_408841 V1223782 S NA 120CJ Cluster_551914 V1223783 S Peptidase, S41 11XDZ Cluster_449030 V1223784 S domain protein 0YNW0 Cluster_820727 V1223786 S NA 0XW6Y Cluster_614119 V1223787 S AcnD-accessory protein PrpF COG2828 Cluster_832251 V1223788 S AcnD-accessory protein PrpF COG2828 Cluster_408843 V1223790 ILVD map00290,map00770,map01100,map01110,map01210,map01230 E, G Dihydroxy-acid dehydratase COG0129 Cluster_429003 V1223791 RIBA map00740,map01100 H Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) COG0807 Cluster_410687 V1223792 DCUA map02020 O Anaerobic c4-dicarboxylate transporter COG2704 Cluster_442978 V1223793 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_796974 V1223794 S NA 0YPHQ Cluster_695922 V1223795 L transposase COG1943 Cluster_465131 V1223796 FUMC map00020,map00720,map01100,map01110,map01120,map05200,map05211 C fumarate hydratase class II COG0114 Cluster_408844 V1223797 SUFC O feS assembly ATPase SufC COG0396 Cluster_432985 V1223798 K helix-turn-helix domain protein COG2856 Cluster_410688 V1223799 T Metal dependent phosphohydrolase COG2206 Cluster_576424 V1223800 ASPB K Transcriptional regulator COG1167 Cluster_293748 V1022201 THID map00730,map01100 H phosphomethylpyrimidine kinase COG0351 Cluster_170173 V1022202 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_355034 V1022203 TAL map00030,map01100,map01110,map01120,map01230 G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) COG0176 Cluster_270819 V1022204 FADB2 map00360,map00362,map00650,map01100,map01120 I Dehydrogenase COG1250 Cluster_355035 V1022205 RSSA I Phospholipase, patatin family COG4667 Cluster_602323 V1022206 PEPP E peptidase, M24 COG0006 Cluster_381956 V1022210 map02020 K Transcriptional regulator COG2197 Cluster_171809 V1022215 PCRA map03420,map03430 L helicase COG0210 Cluster_256228 V1022219 MVAN_1091 L Integrase catalytic subunit COG2801 Cluster_207027 V1022220 ADHP map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120 C alcohol dehydrogenase COG1064 Cluster_291047 V1022221 S NA 0ZRFK Cluster_444558 V1022223 AROK map00400,map01100,map01110,map01230 E Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) COG0703 Cluster_172708 V1022224 PTPA map04974 E peptidase COG1506 Cluster_281468 V1022225 S NA 11NH0 Cluster_454552 V1022228 V Inherit from COG: Type I site-specific deoxyribonuclease COG0610 Cluster_511886 V1022229 M Polysaccharide Biosynthesis Protein COG2244 Cluster_172709 V1022230 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_295162 V1022237 TAGG map02010 G, M permease protein COG1682 Cluster_399649 V1022240 SPL M NlpC/P60 family COG0791 Cluster_173566 V1022244 MVAS map00072,map00280,map00650,map00900,map01100,map01110 I Hydroxymethylglutaryl-CoA synthase COG3425 Cluster_173567 V1022245 ALDA map00010,map00040,map00053,map00071,map00280,map00281,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00626,map00640,map00903,map01100,map01110,map01120 C Aldehyde dehydrogenase family COG1012 Cluster_356751 V1022249 NT5E map00230,map00240,map00630,map00760,map01100,map01110 S Hydrolase COG0546 Cluster_827724 V1022250 map05132 M repeat protein COG3209 Cluster_173568 V1022255 V Type I restriction modification DNA specificity domain COG0732 Cluster_363228 V1022257 YDFF K arsR family transcriptional regulator COG0640 Cluster_572447 V1022258 RPSK map03010 J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) COG0100 Cluster_266744 V1022259 S NA 11Q0J Cluster_208155 V1022260 map00910 S 2-Nitropropane dioxygenase COG2070 Cluster_276148 V1022262 S NA 12BYI Cluster_202722 V1022264 LPXD map00540,map01100 M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) COG1044 Cluster_276149 V1022265 S NA 12BYI Cluster_215943 V1022266 U, W domain protein COG5295 Cluster_454553 V1022269 PPIB O PPIases accelerate the folding of proteins (By similarity) COG0652 Cluster_340738 V1022271 LNT M Transfers the fatty acyl group on membrane lipoproteins (By similarity) COG0815 Cluster_588480 V1022272 S NA 0YHMG Cluster_843169 V1022273 DDH map00300,map01100,map01110,map01230 E Diaminopimelate dehydrogenase 0XPX2 Cluster_269500 V1022274 map00030,map00650,map01120 S Dehydrogenase 0XNUN Cluster_373255 V1022276 L Replication Protein 0YRQ2 Cluster_175989 V1022279 SPEB S peptidase C10 11SDT Cluster_175990 V1022282 S OmpA family 0YMNW Cluster_450567 V1022285 MUCPA_5825 S Protein of unknown function (DUF935) 11VDI Cluster_542259 V1022286 S Protein of unknown function (DUF1320) 12DBA Cluster_176827 V1022287 S NA 11P3R Cluster_264083 V1022288 RECE L exonuclease VIII 174DI@proNOG Cluster_456482 V1022290 M Alpha beta hydrolase fold COG1073 Cluster_458408 V1022292 MANA map00051,map00520,map01100,map01110 G mannose-6-phosphate isomerase COG1482 Cluster_262726 V1022293 PPNK map00760,map01100 G Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) COG0061 Cluster_383740 V1022298 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_177630 V1022305 M Cell wall binding repeat 2-containing protein COG2247 Cluster_306290 V1022306 S NA 11JHM Cluster_554128 V1022307 OCAR_4302 S Protein of unknown function (DUF1232) COG3339 Cluster_442551 V1022308 S SusD family 0XPTK Cluster_287057 V1022310 L D12 class N6 adenine-specific DNA methyltransferase 110K5 Cluster_366691 V1022317 V Restriction modification system DNA (Specificity COG0732 Cluster_179344 V1022318 GLTD map00250,map00910,map01100,map01110,map01120,map01230 C, E pyridine nucleotide-disulfide oxidoreductase COG1894 Cluster_368319 V1022319 YRBL S transferase activity, transferring phosphorus-containing groups 175ZH@proNOG Cluster_296562 V1022323 M hydrolase, family 25 COG3757 Cluster_389065 V1022329 SCLAV_0672 P integral membrane protein COG1253 Cluster_313428 V1022332 PG0694 M major outer membrane protein OmpA 11X18 Cluster_504189 V1022333 SEPF S Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) COG1799 Cluster_691180 V1022334 GDHA map00250,map00330,map00910,map01100 E Glutamate dehydrogenase COG0334 Cluster_717499 V1022337 YJBD S Conserved Protein 17CUT@proNOG Cluster_274821 V1022338 S (LipO)protein 11K11 Cluster_588481 V1022340 PKND E ABC transporter substrate-binding protein COG0834 Cluster_333243 V1022341 SSCG_01435 E ABC transporter COG0765 Cluster_780098 V1022342 L Inherit from COG: transposase COG3293 Cluster_506673 V1022343 SSNG_01961 L Transposase COG3293 Cluster_458409 V1022344 S NA 11VHX Cluster_350218 V1022345 TRPF map00400,map01100,map01110,map01230 E N-(5'-phosphoribosyl)anthranilate isomerase COG0135 Cluster_754165 V1022351 S NA 0XNWW Cluster_180169 V1022352 U, W Domain-Containing protein COG5295 Cluster_185400 V1022353 map00500,map01100,map04973 G alpha amylase, catalytic COG0366 Cluster_266745 V1022356 MT0536 V Hnh endonuclease 122A9 Cluster_233495 V1022358 WHIA K May be required for sporulation (By similarity) COG1481 Cluster_211388 V1022359 map00330,map01100,map01110,map01210,map01230 E peptidase COG0624 Cluster_265428 V1022362 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_912225 V1022363 SP_2191 S isoprenylcysteine carboxyl methyltransferase family protein COG1755 Cluster_310435 V1022364 UHPT map02020 G transporter COG2271 Cluster_796110 V1022366 COPZ map04978 P copper ion binding protein 0XUQ1 Cluster_181022 V1022373 PBP2B M penicillin-binding protein COG0768 Cluster_491594 V1022374 OCAR_4103 S cupin superfamily protein COG3542 Cluster_328830 V1022375 YBDL map00300,map01100,map01120,map01230 E Aminotransferase COG0436 Cluster_410263 V1022378 RFBC map00521,map00523,map01100,map01110 M Dtdp-4-dehydrorhamnose 3,5-epimerase COG1898 Cluster_419286 V1022381 SCLAV_4066 S NA 11QJK Cluster_242286 V1022385 NADA map00760,map01100 H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) COG0379 Cluster_270820 V1022388 TRPB map00260,map00400,map01100,map01110,map01230 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) COG0133 Cluster_244925 V1022389 PANE map00770,map01100,map01110 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) COG1893 Cluster_682173 V1022390 YAJC map03060,map03070 U Preprotein translocase YajC subunit 0XVGY Cluster_466708 V1022397 S isoprenylcysteine carboxyl methyltransferase COG1755 Cluster_313429 V1022398 COAX map00770,map01100 K Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) COG1521 Cluster_410689 V1223803 T Histidine kinase COG0642 Cluster_410690 V1223804 L Integrase COG0582 Cluster_661289 V1223805 map00071,map00280,map00281,map00650,map01100,map01110 I acyl-Coa dehydrogenase COG1960 Cluster_410692 V1223807 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_487273 V1223810 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_674170 V1223812 S conserved domain protein 11RSW Cluster_410694 V1223814 map05100 M Repeat protein COG4886 Cluster_458879 V1223816 K Tetr family transcriptional regulator 128EX Cluster_734696 V1223817 YEEN K transcriptional regulatory protein COG0217 Cluster_820728 V1223818 S domain protein 17QHA@proNOG Cluster_504719 V1223820 DNAE2 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase (By similarity) COG0587 Cluster_705369 V1223821 PRIA map03440 L Primosomal protein n' COG1198 Cluster_410695 V1223823 HSDR V type iii restriction COG4096 Cluster_410696 V1223824 CODB F permease for cytosine purines, uracil, thiamine, allantoin COG1457 Cluster_449031 V1223825 HISF map00340,map01100,map01110,map01230 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) COG0107 Cluster_410698 V1223827 V ABC transporter 0ZVG0 Cluster_699196 V1223828 L NA 0YJFA Cluster_769972 V1223829 L NA 0YKV1 Cluster_793021 V1223832 PHAJ I MaoC domain protein dehydratase COG2030 Cluster_410699 V1223834 FATD map02010 P permease protein COG4606 Cluster_721548 V1223837 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_754985 V1223838 RPSO map03010 J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) COG0184 Cluster_412507 V1223839 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_766238 V1223841 VIUB P Siderophore-interacting protein COG2375 Cluster_773643 V1223843 THIS map04122 H Thiamine biosynthesis protein thiS 0XUTZ Cluster_444956 V1223851 S NA 0Z9VZ Cluster_414374 V1223852 V restriction COG1401 Cluster_412509 V1223853 VICR map02020 T response regulator COG0745 Cluster_485001 V1223856 GLK map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G Glucokinase COG1940 Cluster_692106 V1223857 L NA 0YJFA Cluster_414375 V1223860 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_414376 V1223862 map00020,map00310,map00380,map01100,map01110,map01120 C 2-oxoglutarate dehydrogenase, E1 subunit COG0567 Cluster_863888 V1223865 U, W Pfam:YadA COG5295 Cluster_454970 V1223866 GLTT E glutamate COG0786 Cluster_528842 V1223867 LTAE map00260,map01100,map01110,map01120,map01230 E Aldolase COG2008 Cluster_414377 V1223869 MT2601 S secreted protein 11JUS Cluster_477954 V1223871 S Protein of unknown function (DUF3375) 0XQSA Cluster_414378 V1223874 V abc transporter permease protein 11F1K Cluster_414379 V1223875 S NA 11NI8 Cluster_414380 V1223877 FADD2 Q Acyl-CoA synthetase COG0318 Cluster_657058 V1223878 ADDA L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation COG1074 Cluster_416153 V1223879 S NA 0ZMA4 Cluster_414381 V1223880 map03440 K Transcriptional regulator COG2865 Cluster_416154 V1223883 ESSC D ftsk spoIIIe COG1674 Cluster_789238 V1223884 MODC map02010 P ABC transporter COG3842 Cluster_509885 V1223885 ABGT H Transporter COG2978 Cluster_414382 V1223887 ACNA map00020,map00300,map00630,map00720,map01100,map01110,map01120,map01210,map01230 C aconitate hydratase COG1048 Cluster_489632 V1223891 MURG map00550,map01100,map04112 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) COG0707 Cluster_494612 V1223892 GPMA map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0588 Cluster_414383 V1223895 DACB map00550 M d-alanyl-d-alanine carboxypeptidase COG2027 Cluster_477955 V1223897 PPIB O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) COG0652 Cluster_512465 V1223900 HFLX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COG2262 Cluster_416156 V1223902 RV1278 S growth 0ZW9I Cluster_909037 V1223904 SUCB map00010,map00020,map00280,map00310,map00620,map01100,map01110,map01120 C 2-oxoglutarate dehydrogenase E2 component, dihydrolipoamide succinyltransferase COG0508 Cluster_554777 V1223905 S NA 123I8 Cluster_416157 V1223906 P sulfate transporter COG0659 Cluster_549009 V1223909 S NA 11UWB Cluster_585954 V1223910 MNTB map02010,map02020 P (ABC) transporter COG1121 Cluster_796976 V1223911 MTSC map02010,map02020 P ABC transporter COG1108 Cluster_417961 V1223914 S Pyrogenic exotoxin B 11S8V Cluster_416159 V1223915 S Membrane 11WHS Cluster_417962 V1223916 S NA 0YPHQ Cluster_526090 V1223920 CHRA P Chromate COG2059 Cluster_416160 V1223921 METY map00270,map01100 E O-Acetylhomoserine COG2873 Cluster_416162 V1223923 CYA map00230,map04113 T Adenylate cyclase COG2114 Cluster_417963 V1223926 P TonB dependent receptor 0XNNV Cluster_417964 V1223930 MT2607 map00330,map00480,map01100,map01110 E decarboxylase COG1982 Cluster_417965 V1223931 S Pfam:DUF2081 COG3472 Cluster_421526 V1223933 ARCD E Arginine ornithine antiporter COG0531 Cluster_419729 V1223934 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_721549 V1223935 C Monooxygenase COG2141 Cluster_657059 V1223937 MUTY map03410 L a g-specific adenine glycosylase COG1194 Cluster_554778 V1223939 L resolvase COG1961 Cluster_417966 V1223940 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_554779 V1223941 O cysteine protease COG4870 Cluster_543016 V1223943 WECB map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_793022 V1223946 DNAE2 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase (By similarity) COG0587 Cluster_504720 V1223947 MEPR K Transcriptional regulator 121PJ Cluster_417967 V1223948 E (ABC) transporter COG4608 Cluster_447002 V1223950 MT1523 S Membrane 12CTB Cluster_724899 V1223951 NOSF map02010 V ABC transporter COG1131 Cluster_644800 V1223952 NOSY S nitrous-oxide metabolic protein nosy 0XSQP Cluster_419730 V1223953 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_419731 V1223956 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_419732 V1223957 MURD map00471,map00550,map01100 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COG0771 Cluster_419733 V1223958 S Protein of unknown function (DUF1524) COG1479 Cluster_419735 V1223962 GBRO_2584 L integrase family COG0582 Cluster_421527 V1223965 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_497119 V1223967 DEF J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) COG0242 Cluster_419736 V1223969 GLVR K Transcriptional regulator COG1737 Cluster_419737 V1223970 M Pilin isopeptide linkage domain protein 11AV1 Cluster_497120 V1223972 LPQB S lipoprotein lpqb 0ZF99 Cluster_665458 V1223973 CTAF C Part of cytochrome c oxidase, its function is 11R1D Cluster_744759 V1223974 COXB map00190,map00910,map01100 C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) COG1622 Cluster_436956 V1223975 HUTI map00340,map01100 Q imidazolone-5-propionate hydrolase COG1228 Cluster_473607 V1223976 G Glycoside hydrolase family 76 COG4833 Cluster_836148 V1223977 RPMD map03010 J 50S ribosomal protein L30 COG1841 Cluster_621553 V1223978 MURG map00550,map01100,map04112 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) COG0707 Cluster_606805 V1223980 SORA C Superoxide reductase COG2033 Cluster_421528 V1223981 PGDA G Polysaccharide deacetylase COG0726 Cluster_551915 V1223983 FHAB T Fha domain containing protein COG1716 Cluster_789239 V1223986 CSPA K Cold shock protein COG1278 Cluster_450993 V1223987 SODA map04146,map05016 P Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) COG0605 Cluster_596112 V1223988 D Inherit from COG: Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) COG3599 Cluster_421530 V1223990 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_840018 V1223991 L Excinuclease ABC C subunit domain protein COG2827 Cluster_636910 V1223993 YIEG S Xanthine uracil vitamin C permease COG2252 Cluster_603193 V1223997 PKNA T serine threonine protein kinase COG0515 Cluster_785242 V1223998 PBPA map00550 M penicillin-binding protein COG0768 Cluster_421531 V1223999 CAS3 L CRISPR-associated helicase, cas3 COG1203 Cluster_421532 V1224000 S Protein of unknown function (DUF2029) 0Y6D7 Cluster_421534 V1224005 SHC P drug resistance transporter, EmrB QacA subfamily 0XNN3 Cluster_421535 V1224008 S NA 0YCCW Cluster_617881 V1224009 ACNA map00020,map00300,map00630,map00720,map01100,map01110,map01120,map01210,map01230 C aconitate hydratase COG1048 Cluster_517847 V1224010 NFED O nodulation efficiency protein D COG1030 Cluster_617882 V1224011 THRC map00260,map00750,map01100,map01120,map01230 E threonine synthase COG0498 Cluster_871838 V1224012 G Major Facilitator superfamily 0XPEM Cluster_487274 V1224014 YAAA L UPF0246 protein COG3022 Cluster_824714 V1224015 RV0495C S NA 0ZV27 Cluster_718220 V1224016 PPX1 map00230 F, P ppx gppa phosphatase COG0248 Cluster_423387 V1224019 M NA 0ZY8Y Cluster_423388 V1224020 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_494613 V1224021 SPR M Nlp p60 protein COG0791 Cluster_754986 V1224022 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_617883 V1224024 FEUA map02010 P abc transporter atp-binding protein COG4604 Cluster_928891 V1224025 TRPD map00400,map01100,map01110,map01230 E anthranilate phosphoribosyltransferase COG0547 Cluster_423389 V1224026 PEPC E aminopeptidase c COG3579 Cluster_423390 V1224028 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_699197 V1224030 S Nadph-dependent fmn reductase COG0431 Cluster_758509 V1224031 PRFC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) COG4108 Cluster_430980 V1224032 RV1324 O Thioredoxin COG3118 Cluster_454971 V1224034 TOPB L Dna topoisomerase COG0550 Cluster_545955 V1224036 CSP M n-acetylmuramoyl-l-alanine amidase COG5479 Cluster_665459 V1224037 CORA P magnesium and cobalt transport protein CorA COG0598 Cluster_785243 V1224038 MT1272 S NA 11TNI Cluster_423391 V1224039 SPPA O, U Signal peptide peptidase, SppA COG0616 Cluster_489634 V1224040 PBUG S Xanthine uracil vitamin C permease COG2252 Cluster_423393 V1224042 U, W Pfam:HIM COG5295 Cluster_769974 V1224043 S NA 0XYN2 Cluster_847994 V1224047 GLTA map00020,map00630,map01100,map01110,map01120,map01210,map01230 C citrate synthase COG0372 Cluster_900592 V1224048 MCSA S Uvrb UvrC protein COG3880 Cluster_520393 V1224049 CTSR K transcriptional regulator, ctsr COG4463 Cluster_425176 V1224050 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_589272 V1224051 G transporter 0XP7I Cluster_563711 V1224053 S transmembrane signal peptide protein COG3169 Cluster_425177 V1224054 WHIA K May be required for sporulation (By similarity) COG1481 Cluster_432986 V1224055 MT3340 S Phosphoribosyl transferase domain COG1040 Cluster_425179 V1224057 HEMC map00860,map01100,map01110 H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) COG0181 Cluster_674171 V1224058 map00270,map01100,map04122 P sulfurtransferase COG2897 Cluster_705370 V1224060 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0847 Cluster_425180 V1224063 ATPA map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_425181 V1224064 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_832252 V1224065 PGN_0946 S Membrane COG1033 Cluster_751527 V1224066 AFTB S Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids 0YKVT Cluster_683147 V1224067 UBIA H Prenyltransferase COG0382 Cluster_425182 V1224068 ARCA map00330,map01100,map01110 E Arginine dihydrolase COG2235 Cluster_425183 V1224069 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_425184 V1224070 YHBJ S Displays ATPase and GTPase activities (By similarity) COG1660 Cluster_425185 V1224071 L UvrD REP helicase COG0210 Cluster_425186 V1224073 TPDA E peptidase COG0624 Cluster_751528 V1224074 S NA 0ZGFA Cluster_425187 V1224076 PRPB map00640 G methylisocitrate lyase COG2513 Cluster_427105 V1224077 S Rib/alpha-like repeat 10008 Cluster_467207 V1224078 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_425188 V1224079 L Transposase 0ZX7U Cluster_427106 V1224080 ATL G the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis COG5632 Cluster_427107 V1224082 M domain protein COG4932 Cluster_621554 V1224083 S Putative amino acid metabolism 122BZ Cluster_450994 V1224084 GYAR map00260,map00680,map01100,map01120,map01230 C Dehydrogenase COG0111 Cluster_573202 V1224085 DUSB J Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_427108 V1224086 SURB S G5 domain protein 0ZVV3 Cluster_429004 V1224088 S NA 11NX4 Cluster_427109 V1224089 IROC map02010 V abc transporter COG1132 Cluster_528843 V1224090 HEMD map00860,map01100,map01110 H synthase COG1587 Cluster_621555 V1224092 RECR map03440 L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) COG0353 Cluster_507296 V1224094 S Phage capsid family 0ZMHM Cluster_429005 V1224095 L DNA primase helicase 0ZVWQ Cluster_427111 V1224097 BMUL_3599 map02010 P ABC transporter COG1129 Cluster_427112 V1224098 SUCB map00010,map00020,map00280,map00310,map00620,map01100,map01110,map01120 C 2-oxoglutarate dehydrogenase E2 component, dihydrolipoamide succinyltransferase COG0508 Cluster_824715 V1224099 RPSZ map03010 J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) COG0199 Cluster_502315 V1224102 RIMM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) COG0806 Cluster_554780 V1224105 ABGT H Transporter COG2978 Cluster_573203 V1224108 ATPH map00190,map00195,map01100 C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) COG0712 Cluster_589273 V1224110 PARB K parb-like partition protein COG1475 Cluster_534428 V1224113 DXR map00900,map01100,map01110 I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) COG0743 Cluster_603194 V1224115 ILVB map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E acetolactate synthase COG0028 Cluster_773647 V1224117 FABD map00061,map01100 I malonyl CoA-acyl carrier protein transacylase COG0331 Cluster_429006 V1224120 AMN map00230 F Amp nucleosidase COG0775 Cluster_480361 V1224121 L nudix hydrolase COG0494 Cluster_699198 V1224122 HUTU map00340,map01100 E Urocanate hydratase COG2987 Cluster_718221 V1224125 CRGA D septation inhibitor protein 121NJ Cluster_507297 V1224126 PTSG map00010,map00500,map00520,map02060 G PTS system COG2190 Cluster_452940 V1224127 GCVP map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG1003 Cluster_430981 V1224128 BCOA_0505 L transposase COG0675 Cluster_430982 V1224130 L DNA helicase COG1112 Cluster_429007 V1224132 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_429008 V1224133 LPQU M MemBrane-bound lytic murein transglycosylase COG2951 Cluster_452941 V1224135 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG2812 Cluster_430983 V1224137 L Integrase COG0582 Cluster_665460 V1224138 S NA 0Z4VD Cluster_465133 V1224139 SUFB O FeS assembly protein SUFB COG0719 Cluster_430984 V1224140 S Hydrolase COG4814 Cluster_579532 V1224142 map00330,map00360,map00380,map00627,map00643,map01120 Q K01426 amidase EC 3.5.1.4 COG0154 Cluster_758510 V1224143 S Conserved Protein COG1556 Cluster_648857 V1224144 BMUL_5818 C Iron-sulfur cluster binding protein COG1139 Cluster_554781 V1224145 THRC map00260,map00750,map01100,map01120,map01230 E threonine synthase COG0498 Cluster_573204 V1224146 CITM C Citrate transporter COG2851 Cluster_629058 V1224148 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_430985 V1224149 EMBC M Arabinosyltransferase 0XSQE Cluster_847996 V1224150 S NA 0ZS1W Cluster_683148 V1224151 HIT F, G Histidine triad (Hit) protein COG0537 Cluster_721550 V1224152 PGSA1 map00562,map00564,map01100,map04070 I Cdp-alcohol phosphatidyltransferase COG0558 Cluster_430986 V1224153 QUEC map00790,map01100 S Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) COG0603 Cluster_573205 V1224154 S Protein of unknown function (DUF1016) COG4804 Cluster_888059 V1224155 S NA 0YUPP Cluster_430987 V1224156 S ATP-dependent OLD family endonuclease 1740Z@proNOG Cluster_859554 V1224157 ETFA map00910 C electron transfer flavoprotein alpha subunit COG2025 Cluster_430988 V1224158 TRPA map00260,map00400,map01100,map01110,map01230 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) COG0159 Cluster_432987 V1224160 YVFR map02010 V ABC transporter COG1131 Cluster_430990 V1224163 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_430991 V1224164 RPOS map05111 K RNA polymerase COG0568 Cluster_589275 V1224166 SCLAV_0101 S metallophosphoesterase COG1409 Cluster_430992 V1224167 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_494614 V1224169 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit alpha COG0587 Cluster_636912 V1224171 SUCD map00020,map00640,map00660,map00720,map01100,map01110,map01120 C Succinyl-CoA ligase ADP-forming subunit alpha COG0074 Cluster_705371 V1224173 TRMB S Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_711604 V1224175 PVDS map00190,map03018 L polyphosphate kinase 2 COG2326 Cluster_665461 V1224178 S NA 0ZUS3 Cluster_855552 V1224179 S NA 0Y5YG Cluster_748107 V1224181 map00473,map05150 Q amino acid adenylation domain protein COG1020 Cluster_718223 V1224184 YQJA S Membrane COG4129 Cluster_447003 V1224185 S NA 11QS8 Cluster_718224 V1224186 PEPD E Dipeptidase COG4690 Cluster_432988 V1224187 PMT M glycosyl transferase, family 39 COG1928 Cluster_793023 V1224190 S UPF0126 domain COG2860 Cluster_432989 V1224191 S NA 0ZMA4 Cluster_480362 V1224193 HADH map00360,map00362,map00650,map01100,map01120 C Dehydrogenase COG1250 Cluster_454972 V1224194 MOEA H molybdopterin biosynthesis protein COG0303 Cluster_467208 V1224195 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_475749 V1224198 YICG S Membrane COG2860 Cluster_482678 V1224201 S Thioesterase 11QVX Cluster_504721 V1224203 METX map00270,map00920,map01100 E Homoserine O-trans-acetylase COG2021 Cluster_796980 V1224206 K Transcriptional regulator GntR family COG1167 Cluster_442979 V1224209 S Vitamin K epoxide reductase 11HU3 Cluster_434899 V1224210 DHAL map00561,map01100 G Dihydroxyacetone kinase COG2376 Cluster_599625 V1224211 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_695923 V1224212 RPSG map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) COG0049 Cluster_432990 V1224213 CCSB O Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) COG1333 Cluster_683149 V1224214 RECB L recb family COG2887 Cluster_432991 V1224215 S phage portal protein, SPP1 0ZZDC Cluster_557696 V1224216 SCAD N, U domain protein COG3942 Cluster_851772 V1224217 S NA 0ZHU9 Cluster_432992 V1224218 METQ map02010 P (Lipo)protein COG1464 Cluster_432993 V1224220 S Transglutaminase-like superfamily 110H2 Cluster_467209 V1224222 O (LipO)protein COG0526 Cluster_744760 V1224224 MTSC P ABC transporter COG1108 Cluster_596113 V1224225 YDIB S ATP-binding protein COG0802 Cluster_748108 V1224228 S Protein of unknown function (DUF3152) 10F95 Cluster_674172 V1224229 MT3300 S NA 0XS4X Cluster_434901 V1224231 DPNA L helicase COG4646 Cluster_705372 V1224232 MT2205 S integral membrane protein COG0762 Cluster_744761 V1224233 SEPF S Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) COG1799 Cluster_625337 V1224235 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_434902 V1224236 V LlaJI restriction endonuclease 103AJ Cluster_434903 V1224237 RECG map03420,map03440 L transcription-repair coupling factor COG1197 Cluster_434904 V1224238 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_888060 V1224239 M Arylsulfatase COG1368 Cluster_434905 V1224240 S surface protein 11NE4 Cluster_434906 V1224241 P hemin receptor COG1629 Cluster_592628 V1224245 map00750,map01100 H Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) COG0259 Cluster_434907 V1224249 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_436957 V1224250 ACTP P p-type atpase COG2217 Cluster_434908 V1224253 CSP M n-acetylmuramoyl-l-alanine amidase COG5479 Cluster_434909 V1224254 IROC map02010 V abc transporter COG1132 Cluster_434910 V1224255 MMPL H MMPL domain protein COG2409 Cluster_695924 V1224256 GATB map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 Cluster_436958 V1224259 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_436959 V1224261 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_436960 V1224262 ARC map03050 O ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) COG0464 Cluster_809150 V1224264 INFC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) COG0290 Cluster_809151 V1224265 map03010 J Ribosomal protein L35 0ZZFG Cluster_475750 V1224266 S NA 11JF2 Cluster_560758 V1224267 S Thioesterase COG5496 Cluster_785244 V1224268 M NLP P60 protein COG0791 Cluster_434912 V1224269 S Rib/alpha-like repeat 10008 Cluster_632882 V1224270 LACZ map00052,map00511,map00600,map01100 G beta galactosidase small chain COG3250 Cluster_557697 V1224272 S NA 11H3H Cluster_436961 V1224273 TIG O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COG0544 Cluster_436962 V1224274 RBSC map02010,map02030 G abc transporter COG1879 Cluster_436963 V1224278 map02010 P ABC transporter, permease COG1175 Cluster_436964 V1224279 U, W domain protein COG5295 Cluster_932105 V1224280 S NA 0ZHU9 Cluster_644801 V1224281 M Sulfatase COG1368 Cluster_438983 V1224282 DPPD map02010 S ABC transporter COG1123 Cluster_724902 V1224283 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_436965 V1224284 LDTA S ErfK YbiS YcfS YnhG COG1376 Cluster_436966 V1224285 IROC map02010 V abc transporter COG1132 Cluster_438984 V1224288 RECO map03440 L Involved in DNA repair and RecF pathway recombination (By similarity) 0XR7P Cluster_438985 V1224291 S Inherit from NOG: cytoplasmic protein 0XW40 Cluster_557698 V1224293 I Diacylglycerol kinase catalytic domain COG1597 Cluster_652939 V1224294 CELC map02060 G PTS System COG1447 Cluster_847997 V1224295 FOLP map00790,map01100 H dihydropteroate synthase COG0294 Cluster_585955 V1224296 FOLE map00790,map01100 H GTP cyclohydrolase i COG0302 Cluster_460919 V1224298 S aaa ATPase COG3910 Cluster_438986 V1224301 S NA 0Y0TP Cluster_438987 V1224302 GLGE map00500,map01100,map04973 G Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) COG0366 Cluster_475751 V1224303 S Virulence-associated protein D COG3309 Cluster_777371 V1224304 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_450995 V1224305 NUDF map00230 F nudix hydrolase COG0494 Cluster_499779 V1224307 O cysteine protease COG4870 Cluster_465134 V1224308 THRS map00020,map00300,map00630,map00720,map01100,map01110,map01120,map01210,map01230 C Aconitate hydratase COG1048 Cluster_438989 V1224314 TRAA L TrwC relaxase COG0507 Cluster_438990 V1224315 VNCS T Histidine kinase COG0642 Cluster_438991 V1224316 OTSA map00500,map01100 G alpha-alpha-trehalose-phosphate synthase COG0380 Cluster_438992 V1224317 CRTI map00906,map01100,map01110 Q phytoene COG1233 Cluster_867897 V1224318 S NA 0ZIRI Cluster_603196 V1224319 SCLAV_4418 L decarboxylase COG1611 Cluster_438993 V1224320 PYC map00020,map00620,map00720,map01100,map01120,map01230 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) COG1038 Cluster_438994 V1224321 PFK map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G K00850 6-phosphofructokinase 1 EC 2.7.1.11 COG0205 Cluster_438995 V1224327 MRCB map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_438996 V1224328 QCRB map00190,map00195,map00910,map01100,map02020,map04260,map05010,map05012,map05016 C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) COG1290 Cluster_440967 V1224329 RV1278 S growth 0ZW9I Cluster_440968 V1224330 S Rib/alpha-like repeat 10008 Cluster_438997 V1224331 S Pfam:YadA 0ZHSU Cluster_438998 V1224334 MMPL H MMPL domain protein COG2409 Cluster_440969 V1224335 METE map00270,map00450,map01100,map01110,map01230 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) COG0620 Cluster_440970 V1224336 S Protein of unknown function (DUF1524) COG3586 Cluster_440971 V1224337 FAS map00061,map01100 I fatty acid synthase COG4982 Cluster_711605 V1224339 PPP map03070 T phosphatase COG0631 Cluster_718225 V1224340 T fha domain-containing protein COG1716 Cluster_440973 V1224342 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_440974 V1224343 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_440975 V1224344 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_440976 V1224345 FAS map00061,map01100 I fatty acid synthase COG4982 Cluster_440977 V1224346 IOLTB G ABC transporter COG1172 Cluster_440978 V1224347 HEMA map00860,map01100,map01110 H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) COG0373 Cluster_440979 V1224348 SUSC P outer membrane protein SusC 0XNNV Cluster_793024 V1224350 S NA 11QFB Cluster_805110 V1224351 S Methyltransferase 0XQTC Cluster_442980 V1224352 S Relaxase mobilization nuclease 0Y9PG Cluster_458880 V1224354 O Putative Ig domain COG4934 Cluster_440980 V1224356 PHOR map02020 T Histidine kinase 0XNMH Cluster_678611 V1224357 V Abi-like protein COG4823 Cluster_440981 V1224358 MCCF V Peptidase U61, LD-carboxypeptidase A COG1619 Cluster_728167 V1224360 S 5'-phosphate oxidase COG3576 Cluster_840021 V1224362 RNZ map03013 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) COG1234 Cluster_442982 V1224363 RV2219 S integral membrane protein 0Z3WW Cluster_793025 V1224365 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_442983 V1224366 SUFB O FeS assembly protein SUFB COG0719 Cluster_442984 V1224368 PPP map03070 T phosphatase COG0631 Cluster_440982 V1224369 K, T Peptidase S24-like COG1974 Cluster_537323 V1224370 U, W Inherit from COG: domain protein COG5295 Cluster_665463 V1224371 UREB map00230,map00330,map00791,map01100,map01120,map05120 E Urea amidohydrolase subunit beta COG0832 Cluster_669774 V1224373 S acetyltransferase 11W28 Cluster_692107 V1224374 PSTA map02010 P phosphate ABC transporter, permease COG0581 Cluster_442985 V1224375 FTSX map02010 D Part of the ABC transporter FtsEX involved in cellular division (By similarity) COG2177 Cluster_442986 V1224378 S YitT family COG1284 Cluster_442987 V1224379 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_678612 V1224381 CITM C Citrate transporter COG2851 Cluster_832254 V1224383 NTH map03410 L endonuclease III COG0177 Cluster_442989 V1224388 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_444958 V1224391 S Terminase-like family COG5362 Cluster_442990 V1224393 S NA 101UU Cluster_687581 V1224394 S NA 11SZV Cluster_444959 V1224396 RFBD map00521,map00523,map01100,map01110 M Dtdp-4-dehydrorhamnose reductase COG1091 Cluster_444960 V1224398 GLGB map00500,map01100,map01110 G 1,4-alpha-glucan branching enzyme COG0296 Cluster_471499 V1224399 CST2 L CRISPR-associated regulatory protein DevR family COG1857 Cluster_644802 V1224400 YXEA map02010 V ABC transporter, permease COG0577 Cluster_721551 V1224402 P drug resistance transporter, EmrB QacA subfamily 0XNN3 Cluster_867898 V1224403 MURD map00471,map00550,map01100 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COG0771 Cluster_566910 V1224404 MURG map00550,map01100,map04112 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) COG0707 Cluster_444961 V1224407 E solute binding transport lipoprotein COG0747 Cluster_444962 V1224408 map02020 T Histidine kinase COG0642 Cluster_444964 V1224410 MIAB J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) COG0621 Cluster_444965 V1224411 K, T Peptidase S24-like COG1974 Cluster_444966 V1224412 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_444967 V1224415 DPRA L DNA protecting protein DprA COG0758 Cluster_492132 V1224416 FMT S decarboxylase family COG1611 Cluster_824720 V1224418 UDK map00240,map00710,map00983,map01100,map01120 F uridine monophosphokinase COG0572 Cluster_610469 V1224419 GLGB map00500,map01100,map01110 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) COG0296 Cluster_469349 V1224421 ASRC C Sulfite reductase COG2221 Cluster_447004 V1224422 ILVB map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E acetolactate synthase COG0028 Cluster_444969 V1224423 S Putative amidoligase enzyme 0ZJBJ Cluster_447005 V1224424 YFEH G Bile acid COG0385 Cluster_444970 V1224426 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_452942 V1224427 map02010 S ABC transporter COG1123 Cluster_832256 V1224428 YBHL S Membrane COG0670 Cluster_847999 V1224429 F Inherit from COG: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_444971 V1224430 THIO map00730 E glycine oxidase COG0665 Cluster_444972 V1224431 O Arginine-specific protease ArgI polyprotein 0YH82 Cluster_507298 V1224432 HUNADC P transporter COG0471 Cluster_444973 V1224433 THIF H MoeZ/MoeB domain COG0607 Cluster_444974 V1224435 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_497121 V1224436 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_502316 V1224437 K GntR family transcriptional regulator COG1802 Cluster_444975 V1224441 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_589276 V1224442 S NA 0ZKIP Cluster_444976 V1224444 map02010 G ABC transporter COG1653 Cluster_718226 V1224446 K Transcriptional regulator 11ZVB Cluster_444977 V1224447 VIRB9 map03070,map05120 U TRANSFER protein COG3504 Cluster_447007 V1224448 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_644803 V1224449 S NA 11WJ1 Cluster_805111 V1224450 S NA 122P2 Cluster_657062 V1224452 P transporter COG0471 Cluster_447008 V1224453 L Dna topoisomerase COG0550 Cluster_813143 V1224454 DCTP C symporter COG1301 Cluster_447010 V1224456 SCLAV_0908 K GntR family transcriptional regulator COG2186 Cluster_447011 V1224457 S NA 0Z0KZ Cluster_499780 V1224459 HEMB map00860,map01100,map01110 H delta-aminolevulinic acid dehydratase COG0113 Cluster_674173 V1224460 SCOB map00072,map00280,map00281,map00626,map00627,map00640,map00650,map01100,map01110,map01120,map02020 I CoA-transferase subunit B COG2057 Cluster_447012 V1224461 HELZ L Helicase COG0553 Cluster_447013 V1224462 MPTA S Membrane 0XT70 Cluster_447014 V1224463 SCLAV_2230 V ABC, transporter COG0577 Cluster_447015 V1224464 S Terminase 0XRHX Cluster_758511 V1224465 S NA 11FQQ Cluster_692108 V1224466 P Rhodanese domain protein COG0607 Cluster_473608 V1224468 CCSB O Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) COG1333 Cluster_447016 V1224469 MAF D MAF-like protein COG0424 Cluster_447017 V1224470 CJAA map02010,map02020 E ABC transporter substrate-binding protein COG0834 Cluster_447018 V1224471 DPRA L DNA protecting protein DprA COG0758 Cluster_515169 V1224472 RES_1 V type IIi COG3421 Cluster_625338 V1224473 S NA 0ZHU9 Cluster_447019 V1224475 map02010 P cobalt transport COG0619 Cluster_447020 V1224477 NHAC-1 map00680 C Na H antiporter COG1757 Cluster_477958 V1224478 map00311,map00312,map01110,map02020 V Inherit from COG: Beta-lactamase COG2367 Cluster_447021 V1224479 SBCD L exonuclease COG0420 Cluster_557699 V1224481 CG2401 M Secreted protein COG0791 Cluster_494616 V1224482 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_449032 V1224483 S Collagen triple helix repeat 0YHFV Cluster_515170 V1224484 GALE map00052,map00520,map01100,map01110 M udp-glucose 4-epimerase COG1087 Cluster_449033 V1224485 THIE map00730,map01100 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) COG0422 Cluster_813144 V1224487 CZCD P cation diffusion facilitator family transporter COG0053 Cluster_734698 V1224489 S domain protein 0Y62D Cluster_449035 V1224491 SCLAV_2537 J methyltransferase COG2890 Cluster_449038 V1224499 E Peptidase dimerisation domain COG1473 Cluster_449039 V1224502 MEND map00130,map01100,map01110 H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) COG1165 Cluster_449040 V1224503 M NA 0ZP9N Cluster_762272 V1224505 LPDA map00010,map00020,map00260,map00280,map00620,map01100,map01110,map01120 C Flavoprotein disulfide reductase COG1249 Cluster_449041 V1224506 TRAA L TrwC relaxase COG0507 Cluster_449042 V1224507 PAFA1 S proteasome 0XQPS Cluster_492133 V1224508 DKGB map00051,map00363,map00591,map00625,map00650,map01100,map01120 C reductase COG0656 Cluster_449043 V1224509 ANSP E amino acid COG1113 Cluster_450996 V1224511 ASNB map00250,map00910,map01100,map01110,map01120 E asparagine synthetase COG0367 Cluster_489636 V1224513 CWLM M n-acetylmuramoyl-l-alanine amidase COG3409 Cluster_450997 V1224514 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_563712 V1224515 K Tetr family transcriptional regulator 128EX Cluster_450998 V1224517 APEA map00480,map01100 E M18 family aminopeptidase COG1362 Cluster_463042 V1224519 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_582773 V1224521 LIPW I Alpha beta hydrolase COG0657 Cluster_451000 V1224522 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_789242 V1224523 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_734699 V1224524 YRKD S Pfam:DUF156 COG1937 Cluster_463043 V1224525 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_728168 V1224526 map02010 V ABC transporter COG1131 Cluster_840022 V1224527 YCFB L NUDIX hydrolase COG0494 Cluster_451001 V1224531 GLUD map02010 E amino acid AbC transporter COG0765 Cluster_451002 V1224534 M domain protein COG4932 Cluster_762273 V1224535 GLK map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G glucokinase COG1940 Cluster_579534 V1224537 GCVT map00260,map00670,map00910,map01100 E The glycine cleavage system catalyzes the degradation of glycine (By similarity) COG0404 Cluster_451003 V1224538 S peptidase, S41 11FNN Cluster_451005 V1224541 MALQ map00500,map01100,map01110 G 4-alpha-glucanotransferase COG1640 Cluster_625339 V1224542 SCLAV_3035 S Abi-like protein 17N4Q@proNOG Cluster_451006 V1224543 S Conserved Protein COG4804 Cluster_800922 V1224544 RPLT map03010 J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) COG0292 Cluster_748109 V1224545 TSNR J rrna methyltransferase COG0566 Cluster_674174 V1224546 S domain protein 0YNW0 Cluster_540135 V1224549 MRAZ S Cell division protein mraZ COG2001 Cluster_451007 V1224550 UGPA G Binding-protein-dependent transport systems inner membrane component COG1175 Cluster_451008 V1224554 HUTH map00340,map01100 E Histidine ammonia-lyase COG2986 Cluster_585957 V1224557 RLMB J RNA methyltransferase TrmH family group 3 COG0566 Cluster_566911 V1224558 U TraG family COG3505 Cluster_738029 V1224559 S UPF0346 protein COG4479 Cluster_452943 V1224560 U, W surface protein COG5295 Cluster_458882 V1224561 PBP2B M penicillin-binding protein COG0768 Cluster_534430 V1224564 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_648858 V1224565 ENTC map00130,map01053,map01100,map01110 H Isochorismate synthase COG1169 Cluster_451009 V1224566 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_451010 V1224567 FTSW map04112 D Cell division protein, FtsW COG0772 Cluster_531645 V1224570 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_451012 V1224572 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_452945 V1224573 V restriction enzyme COG1002 Cluster_708466 V1224574 BUDC map00061,map00362,map00650,map00780,map01040,map01100,map01120,map01220 S reductase 0XNW1 Cluster_452946 V1224575 S NA 100BM Cluster_482679 V1224576 ATPG map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) COG0224 Cluster_451013 V1224577 DPNA L helicase COG4646 Cluster_451014 V1224578 S NA 11NI8 Cluster_452947 V1224579 map02020 V ABC transporter, permease COG0577 Cluster_640941 V1224581 AZLD E branched-chain amino acid COG1687 Cluster_452948 V1224582 G hydrolase family 16 COG2273 Cluster_554782 V1224584 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E brancheD-chain amino acid aminotransferase COG0115 Cluster_452949 V1224585 MRAY map00550,map01100 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) COG0472 Cluster_636913 V1224586 S NA 18B7I@proNOG Cluster_728169 V1224590 S NA 11MDT Cluster_573206 V1224593 RLUD J Pseudouridine synthase COG0564 Cluster_504722 V1224594 G PTS system fructose IIA component COG3412 Cluster_789243 V1224595 DCUB map02020 O Anaerobic c4-dicarboxylate transporter COG2704 Cluster_452951 V1224597 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_452952 V1224598 RODA D rod shape-determining protein RodA COG0772 Cluster_714977 V1224602 LNT M Transfers the fatty acyl group on membrane lipoproteins (By similarity) COG0815 Cluster_731482 V1224604 RPSQ map03010 J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal COG0186 Cluster_796983 V1224605 RPMC map03010 J 50s ribosomal protein l29 COG0255 Cluster_452953 V1224606 BLT G major facilitator superfamily 0ZVHM Cluster_452954 V1224608 BL00759 L Phage terminase, large subunit COG1783 Cluster_714978 V1224611 S NA 0XPQF Cluster_900594 V1224613 SERB map00260,map00680,map01100,map01120,map01230 E phosphoserine phosphatase COG3830 Cluster_576428 V1224614 S Mammalian cell entry related domain protein 0YWNZ Cluster_452956 V1224616 FAS map00061,map00350,map00362,map00627,map00642,map00903,map01100,map01120 I synthase COG4982 Cluster_454973 V1224619 HRPA L ATP-dependent helicase COG1643 Cluster_617885 V1224621 YERC S protein, YerC YecD COG4496 Cluster_454974 V1224622 CMTA S Trehalose corynomycolyl transferase COG0627 Cluster_509887 V1224624 S NA 11X74 Cluster_669775 V1224625 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_517849 V1224627 USPA3 T Universal stress protein COG0589 Cluster_480364 V1224628 BA_0233 E, P ABC transporter, permease protein COG1173 Cluster_606806 V1224632 HMUV map02010 P Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) COG4559 Cluster_454976 V1224634 S TrbM protein 17H83@proNOG Cluster_731483 V1224635 AGUA map00330,map01100 E Agmatine deiminase COG2957 Cluster_718228 V1224636 S EamA-like transporter family 1224I Cluster_796984 V1224637 GLOA map00620,map04011 E Lactoylglutathione lyase COG0346 Cluster_458883 V1224638 UREG2 F Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) COG0378 Cluster_460920 V1224639 SCLAV_0672 P integral membrane protein COG1253 Cluster_454977 V1224640 SOJ D Chromosome Partitioning Protein COG1192 Cluster_702278 V1224641 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_741448 V1224642 SPOU map00340,map00350,map00624,map01120 J tRNA rRNA methyltransferase COG0566 Cluster_456902 V1224643 RSEP map04112 M Membrane-associated zinc metalloprotease COG0750 Cluster_614122 V1224644 S sigma-70, region 4 11JJM Cluster_674175 V1224646 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_683151 V1224647 LIPS2 map00561,map01100 S Secretory lipase 0YTM1 Cluster_625341 V1224650 YSXB J (ribosomal) protein COG2868 Cluster_840024 V1224651 PEPQ map00310,map00780,map01100 E peptidase M24 COG0006 Cluster_456904 V1224653 ACIN_0074 L Transposase COG3464 Cluster_456905 V1224654 PPSA S pyruvate phosphate dikinase 0XRDW Cluster_456906 V1224655 S Archaeal ATPase 0ZK8A Cluster_456907 V1224657 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_648859 V1224659 TNPR L resolvase COG1961 Cluster_456909 V1224663 CSN1 L crispr-associated protein COG3513 Cluster_456910 V1224664 MUIA S Inherit from NOG: protein binding 0XS0N Cluster_477959 V1224665 S NA 0YK1E Cluster_456912 V1224667 S NA 10XZZ Cluster_456913 V1224669 D Inherit from COG: Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) COG3599 Cluster_576430 V1224677 IROC map02010 V abc transporter COG1132 Cluster_728170 V1224684 OCAR_6697 map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120 I Enoyl-CoA hydratase COG1024 Cluster_674176 V1224685 COABC map00770,map01100 H Phosphopantothenoylcysteine decarboxylase COG0452 Cluster_456915 V1224686 HRCA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) COG1420 Cluster_699200 V1224687 S NA 11SQP Cluster_569986 V1224688 map00230 S Metal Dependent Phosphohydrolase 11UWJ Cluster_485002 V1224689 SRTA M (sortase) family COG3764 Cluster_859560 V1224691 HPAG H demethylmenaquinone methyltransferase-like protein COG0684 Cluster_499781 V1224692 map00020,map00190,map00623,map00650,map00720,map00984,map01100,map01110,map01120,map02020 C Flavocytochrome c COG1053 Cluster_456916 V1224693 BL01323 M Cell wall binding repeat 2-containing protein 0ZKZU Cluster_596115 V1224696 LEUA map00290,map00620,map01100,map01110,map01210,map01230 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) COG0119 Cluster_793026 V1224697 S NA 11H99 Cluster_661294 V1224698 SBCC3 S Cytosolic protein COG4913 Cluster_458884 V1224699 S NA 0XQBQ Cluster_582774 V1224700 S glycosyltransferase 0Y8FN Cluster_692110 V1224703 BION map02010 P Cobalt transport protein COG0619 Cluster_456917 V1224705 E Family 5 COG0747 Cluster_456918 V1224706 SELD map00450,map01100 E Synthesizes selenophosphate from selenide and ATP (By similarity) COG0709 Cluster_800923 V1224708 PBUX F permease COG2233 Cluster_531646 V1224709 S NA 0XSP9 Cluster_785246 V1224710 S Dehydrogenase 0ZD92 Cluster_458885 V1224713 SSCG_03007 S ABC, transporter 0XNW9 Cluster_512467 V1224716 L SLBB domain COG1555 Cluster_458886 V1224717 S Protein of unknown function DUF262 COG1479 Cluster_751530 V1224718 HMUO map00860,map04978 P Heme oxygenase COG5398 Cluster_800924 V1224719 MAG map03410 L 3-methyladenine DNA glycosylase COG2094 Cluster_863893 V1224722 SP_0913 V ABC transporter (Permease COG0577 Cluster_458888 V1224725 U, W Pfam:HIM COG5295 Cluster_758513 V1224726 S NA 0ZHU9 Cluster_661295 V1224727 S ATP-binding protein 0XT0N Cluster_458889 V1224731 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_458890 V1224734 S NA 10XZZ Cluster_460921 V1224739 S nosl family 0XP3I Cluster_460922 V1224740 S NA 11QDU Cluster_487277 V1224742 HRPA L ATP-dependent helicase COG1643 Cluster_458893 V1224743 FRUA map00051,map01100,map02060 G PTS System COG1762 Cluster_458894 V1224745 S copper amine 0XP8R Cluster_705374 V1224746 RV0224C map00340,map00350,map00624,map01120 S methyltransferase 0XTDB Cluster_458896 V1224748 FADD32 I, Q amp-dependent synthetase and ligase COG0318 Cluster_531647 V1224749 CLVF map02010 V abc transporter COG1131 Cluster_531648 V1224750 PAAI map00360 Q phenylacetic acid degradation protein COG2050 Cluster_460924 V1224752 S NA 0Y5ZK Cluster_460925 V1224753 FADD map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG0318 Cluster_718229 V1224755 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_460926 V1224756 map03420,map03430 L helicase COG3973 Cluster_460927 V1224757 GCVP map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG1003 Cluster_614123 V1224758 K Transcriptional regulator (LacI family COG1879 Cluster_460928 V1224759 HISE2 E Hydrolase COG0637 Cluster_711607 V1224763 COBB map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_460931 V1224764 S NA 11NJX Cluster_460932 V1224767 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_463045 V1224768 MT3095 S Methionine synthase vitamin-b12 independent 0XYJG Cluster_460935 V1224771 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_644804 V1224772 S Phage virion morphogenesis family 16Y0F@proNOG Cluster_460936 V1224773 PIUB S integral membrane protein COG3182 Cluster_460937 V1224774 S NA 0ZS8U Cluster_460938 V1224775 S NA 12B83 Cluster_460940 V1224778 BMUL_3652 V Abortive infection bacteriophage resistance protein COG4823 Cluster_540137 V1224779 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_494617 V1224780 ETFA map00910 C Electron transfer flavoprotein COG2025 Cluster_460941 V1224781 S NA 11MTE Cluster_678614 V1224782 S PspC domain-containing protein 0Y3A6 Cluster_460942 V1224784 YHGE S domain protein COG1511 Cluster_460943 V1224785 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_460944 V1224786 GBRO_0040 L Transposase COG3464 Cluster_460945 V1224787 RV0433 S ATP-dependent carboxylate-amine ligase (By similarity) COG2170 Cluster_674178 V1224789 RPFI M NlpC/P60 family COG0791 Cluster_614124 V1224790 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_460946 V1224791 PPC map00620,map00680,map00710,map00720,map01100,map01120 C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) COG2352 Cluster_463046 V1224793 SURB S G5 domain protein 0ZVV3 Cluster_520394 V1224794 S NA 0ZVM6 Cluster_463047 V1224795 PURC map00230,map01100,map01110 F SAICAR synthetase COG0152 Cluster_460947 V1224796 TRSE U traE protein COG3451 Cluster_463048 V1224797 ALKA map03410 L 8-oxoguanine DNA glycosylase COG0122 Cluster_463049 V1224799 L DNA polymerase 0XRUF Cluster_531649 V1224800 ELAA S gCN5-related N-acetyltransferase COG2153 Cluster_480366 V1224801 B565_1256 S NA 11JBM Cluster_674179 V1224802 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0587 Cluster_460948 V1224803 RSEP map04112 M Membrane-associated zinc metalloprotease COG0750 Cluster_460949 V1224804 RMUC S Dna recombination protein COG1322 Cluster_820732 V1224805 RPMB map03010 J 50S ribosomal protein L28 COG0227 Cluster_463051 V1224807 S NA 11F8K Cluster_463052 V1224808 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 C Phosphofructokinase COG0205 Cluster_463054 V1224811 S NA 0XUFG Cluster_463055 V1224813 S nucleoside recognition domain protein COG3314 Cluster_762274 V1224819 S NA 0XPZB Cluster_789246 V1224820 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_463056 V1224821 S Nitroreductase 11QVA Cluster_683153 V1224823 AROP E amino acid COG1113 Cluster_475752 V1224824 S NA 0ZJ1F Cluster_543017 V1224825 YCHF J gtp-binding protein COG0012 Cluster_463057 V1224826 MEND map00130,map01100,map01110 H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) COG1165 Cluster_463058 V1224830 S Membrane COG4425 Cluster_576432 V1224832 SBCC L Exonuclease COG0419 Cluster_892156 V1224833 ADDB L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination COG3857 Cluster_463060 V1224835 SUCA map00020,map00310,map00380,map01100,map01110,map01120 C 2-oxoglutarate dehydrogenase, E1 COG0567 Cluster_463061 V1224836 S Protein of unknown function (DUF935) 16Z3Z@proNOG Cluster_636914 V1224837 YXEA map02010 V ABC transporter, permease COG0577 Cluster_603198 V1224839 MT3888 S NA 11KBZ Cluster_463062 V1224840 XERD L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_492135 V1224842 S NA 0Z2RD Cluster_534431 V1224844 GYRA L DNA gyrase subunit a COG1372 Cluster_509889 V1224845 GAP map00010,map01100,map01110,map01120,map01230,map04066,map05010 G Glyceraldehyde-3-phosphate dehydrogenase COG0057 Cluster_465136 V1224848 FEPG map02010 P transport system, permease COG4779 Cluster_531650 V1224849 map00561,map01100 M Glycosyl transferase (Group 1 COG0438 Cluster_721554 V1224854 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_463064 V1224855 SCLAV_4880 map00500,map01100,map01110 G Glycogen debranching enzyme COG1523 Cluster_465137 V1224856 M Inherit from NOG: Polymorphic outer membrane protein 11KKP Cluster_463065 V1224858 map00071,map03320,map04146,map04920 S carnitine O-acetyltransferase EC 2.3.1.7 0XNZ9 Cluster_738034 V1224859 AARI_34710 L Transposase for insertion sequence 11IYJ Cluster_465138 V1224860 S NA 0Z4XN Cluster_465139 V1224861 RLMB map00340,map00350,map00624,map01120 J RNA methyltransferase TrmH family group 3 COG0566 Cluster_463066 V1224862 S NA 11NI8 Cluster_636915 V1224863 AFTC S integral membrane protein 0XT56 Cluster_463067 V1224864 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_465140 V1224865 SUFD O feS assembly protein SufD COG0719 Cluster_471501 V1224866 M Lipopolysaccharide biosynthesis protein-like protein COG3754 Cluster_741451 V1224869 ANSP E amino acid COG1113 Cluster_463068 V1224870 S Rib/alpha-like repeat 10008 Cluster_549011 V1224871 RNHB map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0164 Cluster_465141 V1224872 S NA 0YRA4 Cluster_699201 V1224874 L transposase COG0675 Cluster_614125 V1224876 PLSX map00561,map00564,map01100 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) COG0416 Cluster_465142 V1224878 PPP map03070 T phosphatase COG0631 Cluster_560759 V1224880 CUTR T Two component transcriptional regulator, winged helix family 0YJQP Cluster_465143 V1224881 YLOV S dak2 domain fusion protein ylov COG1461 Cluster_465144 V1224882 LYSC map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Aspartokinase COG0527 Cluster_781116 V1224885 RBSK map00030 G ribokinase COG0524 Cluster_762275 V1224886 LCOP P Transporter COG1292 Cluster_603199 V1224889 RUVC map03440 L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) COG0817 Cluster_502318 V1224890 RFBA map00521,map00523,map01100,map01110 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) COG1209 Cluster_465145 V1224892 COBA map00860,map01100,map01110 H Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) COG1587 Cluster_702279 V1224893 L DNA methylase n-4 n-6 domain protein COG2189 Cluster_467211 V1224894 S NA 11H5V Cluster_465146 V1224895 MALQ map00500,map01100 G 4-alpha-glucanotransferase COG1640 Cluster_465148 V1224899 S NA 17ZMH@proNOG Cluster_494618 V1224900 S NA 11VAR Cluster_738035 V1224902 ARGJ map00330,map01100,map01110,map01210,map01230 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) COG1364 Cluster_467212 V1224905 NDVA V ABC superfamily ATP binding cassette transporter COG1132 Cluster_896310 V1224906 S von Willebrand factor COG1721 Cluster_467213 V1224908 S degv family COG1307 Cluster_569988 V1224909 RV3669 S Membrane 11U4P Cluster_465149 V1224910 S ATP-binding protein 0XT0N Cluster_467214 V1224911 S NA 0ZMA4 Cluster_728171 V1224912 CAS4 L crispr-associated protein Cas4 COG1468 Cluster_494619 V1224913 CTPC map00190 P heavy metal translocating P-type ATPase COG2217 Cluster_467215 V1224914 MURE map00300,map00550 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_467216 V1224915 ICD map00020,map00290,map00480,map00720,map01100,map01110,map01120,map01210,map01230,map04146 C Isocitrate dehydrogenase, NAD-dependent COG0473 Cluster_467217 V1224916 MREB D Rod shape-determining protein mreb COG1077 Cluster_585958 V1224922 BMUL_5550 M Lytic transglycosylase catalytic COG0741 Cluster_467219 V1224923 TYPA T gtp-binding protein typa COG1217 Cluster_832258 V1224924 GCDC map00010,map00020,map00362,map00620,map00650,map01100,map01110,map01120 I biotin lipoyl attachment domaiN-containing protein COG0511 Cluster_569989 V1224925 STHIM L DNA methylase COG2189 Cluster_467220 V1224927 ADHE1 map00010,map00051,map00071,map00350,map00363,map00591,map00625,map00626,map00650,map00830,map00980,map00982,map01100,map01110,map01120 C alcohol dehydrogenase COG1062 Cluster_467221 V1224928 PITRM1 O peptidase COG1026 Cluster_805114 V1224929 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_702280 V1224931 S Tetratricopeptide repeat protein 0XZXZ Cluster_566913 V1224933 PPIA O PPIases accelerate the folding of proteins (By similarity) COG0652 Cluster_504723 V1224934 GABD map00250,map00350,map00650,map01100,map01120 C Dehydrogenase COG1012 Cluster_758515 V1224935 PBPA map00550 M penicillin-binding protein COG0768 Cluster_888064 V1224937 RODA map00550,map04112 D cell cycle protein COG0772 Cluster_497122 V1224938 MDSC S Aminoglycoside phosphotransferase 0XP56 Cluster_467222 V1224941 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_467223 V1224942 map00521,map00523,map01100,map01110 M dTDP-4-dehydrorhamnose 3,5-epimerase COG1898 Cluster_509890 V1224943 COBB map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_751531 V1224944 SDHB map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120 C succinate dehydrogenase COG0479 Cluster_554783 V1224946 YQEV J enzyme MiaB COG0621 Cluster_762277 V1224947 S NA 0Y39F Cluster_467224 V1224949 DPNA L helicase COG4646 Cluster_520396 V1224950 P Ferric uptake regulator, Fur family COG0735 Cluster_469350 V1224951 ADH map00051,map00363,map00591,map00625,map00650,map01100,map01120 C iron-containing alcohol dehydrogenase COG1454 Cluster_721555 V1224952 GCVR T UPF0237 protein COG3830 Cluster_471502 V1224953 S NA COG4694 Cluster_828541 V1224954 TYPA T gtp-binding protein typa COG1217 Cluster_467225 V1224956 G Alpha-1,2-mannosidase COG3537 Cluster_469352 V1224957 PEPC E aminopeptidase c COG3579 Cluster_851773 V1224960 MIAB J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) COG0621 Cluster_554784 V1224961 L Transposase COG0675 Cluster_467227 V1224962 C FMN-binding domain protein COG3976 Cluster_702281 V1224965 MENA map00130,map01100,map01110 H 1,4-dihydroxy-2-naphthoate octaprenyltransferase COG1575 Cluster_621558 V1224968 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_531651 V1224969 YVFR map02010 V ABC transporter COG1131 Cluster_469354 V1224971 L transposase InsK for insertion sequence COG2801 Cluster_469355 V1224972 S NA 0ZS8U Cluster_640942 V1224973 RNHB map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0164 Cluster_669776 V1224974 METQ map02010 P (Lipo)protein COG1464 Cluster_512468 V1224976 P ABC transporter substrate-binding protein 0XTCH Cluster_813146 V1224977 GLGC map00500,map00520,map01100,map01110 G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) COG0448 Cluster_665465 V1224978 SAFC map00340,map00350,map00624,map01120 S O-methyltransferase COG4122 Cluster_469356 V1224979 M outer membrane autotransporter barrel domain protein COG3468 Cluster_469357 V1224980 MUTM map03410 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) COG0266 Cluster_469358 V1224981 MANB map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G phosphomannomutase COG1109 Cluster_754988 V1224982 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_728172 V1224985 MAEB map00620,map00710,map01100,map01120,map02020 C Malic enzyme COG0281 Cluster_754989 V1224986 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_469361 V1224991 ACEE map00010,map00020,map00620,map00650,map01100,map01110,map01120 C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) COG2609 Cluster_695925 V1224992 YTSP T gaf domain protein COG1956 Cluster_489637 V1224994 S intracellular protease Pfpi family COG0693 Cluster_648861 V1224995 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_832260 V1224996 NIFU C SUF system FeS assembly protein, NifU family COG0822 Cluster_851774 V1224997 FTSE map02010 D Cell division ATP-binding protein ftsE COG2884 Cluster_471504 V1224998 O Heat shock protein COG0443 Cluster_543018 V1224999 E ABC transporter COG0747 Cluster_554785 V1225000 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_469362 V1225001 COMEC S ComEC rec2-like protein COG0658 Cluster_471505 V1225002 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_551916 V1225003 MENB map00130,map00360,map01100,map01110,map01120 H Naphthoate synthase COG0447 Cluster_469363 V1225006 K transcriptional regulator COG3829 Cluster_816919 V1225007 L dEAD DEAH box helicase COG1205 Cluster_724905 V1225009 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_534432 V1225010 BIOF map00260,map00780,map01100 H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) COG0156 Cluster_471507 V1225011 SSCG_04455 S Methyltransferase 0XSGP Cluster_585959 V1225013 G s-layer domain protein 11MJ3 Cluster_494620 V1225014 map02010 P abc-3 protein COG1108 Cluster_469364 V1225015 PROB map00330,map01100,map01230 E Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) COG0263 Cluster_471508 V1225016 S Lpxtg-motif cell wall anchor domain protein 0XQBH Cluster_471509 V1225017 OLIA S Oligopeptide transporter, Opt family COG1297 Cluster_661296 V1225025 S Inherit from COG: oxidoreductase 0XPNK Cluster_471513 V1225028 SIRR K iron (metal) dependent repressor, dtxr family COG1321 Cluster_471514 V1225030 L Domain protein COG0507 Cluster_512469 V1225034 QOR C Quinone oxidoreductase COG0604 Cluster_471515 V1225035 S ABC transporter, ATPase COG3044 Cluster_471516 V1225036 BCELL_1025 L Integrase COG2801 Cluster_471517 V1225037 ANT_21350 E DNA-binding protein COG2856 Cluster_665466 V1225038 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_471518 V1225039 NRDE map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_589278 V1225040 S Phosphoesterase COG4186 Cluster_497124 V1225041 SCLAV_3539 G phosphoglycerate mutase COG0406 Cluster_487279 V1225043 WANG_1499 S Transposase 11N3I Cluster_523168 V1225044 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_652941 V1225045 TRXA O Thioredoxin COG0526 Cluster_836151 V1225046 MIDI_00056 L Transposase 0YEAS Cluster_471520 V1225049 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_816921 V1225052 map00330,map01100,map01110,map01210,map01230 E peptidase COG0624 Cluster_702282 V1225053 BIOB map00780,map01100 H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) COG0502 Cluster_471521 V1225054 ARGS map00970 J arginyL-tRNA synthetase COG0018 Cluster_471522 V1225055 S Membrane COG2311 Cluster_582775 V1225056 MT1053 D Septum formation initiator family protein COG1507 Cluster_545957 V1225057 S integral membrane protein 11JQ4 Cluster_579537 V1225059 S NA 0ZHU9 Cluster_471523 V1225061 GYRA L DNA gyrase subunit a COG1372 Cluster_471525 V1225065 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_592630 V1225066 ICD map00020,map00480,map00720,map01100,map01110,map01120,map01210,map01230,map04146 C Isocitrate dehydrogenase COG2838 Cluster_473610 V1225067 SSMG_01709 L transposase COG2826 Cluster_473611 V1225068 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_884154 V1225070 DINB L Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) COG0389 Cluster_473612 V1225071 P E1-E2 ATPase COG2217 Cluster_507300 V1225074 RLMB J RNA methyltransferase TrmH family group 3 COG0566 Cluster_809155 V1225077 RIBB map00740,map01100 H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) COG0807 Cluster_699202 V1225078 RIBE map00740,map01100 H riboflavin synthase, subunit alpha COG0307 Cluster_473614 V1225080 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_744766 V1225082 S NA 122IS Cluster_473615 V1225084 map03440 L UvrD REP helicase COG1074 Cluster_473616 V1225089 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_473617 V1225093 OCAR_7338 S trap transporter, 4tm 12tm fusion protein COG4666 Cluster_473618 V1225094 THII map00730,map01100,map04122 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) COG0301 Cluster_473619 V1225095 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_473620 V1225096 S Tape measure protein COG5281 Cluster_480367 V1225097 FABG1 map00061,map00780,map01040,map01100 S short-chain dehydrogenase reductase 0XPR5 Cluster_473621 V1225098 M NA 0YDBK Cluster_683154 V1225099 YQFO S dinuclear metal center protein, YbgI family COG0327 Cluster_475754 V1225100 MT0885 S NA 0XPFG Cluster_699203 V1225101 CCPB K laci family transcriptional regulator 11HUZ Cluster_563714 V1225103 K Sigma-70, region 4 0Z5XZ Cluster_475755 V1225105 S NA 11NI8 Cluster_563715 V1225106 HP1117 S Cysteine-rich protein COG0790 Cluster_724906 V1225107 BL02883 S Membrane 0XVF5 Cluster_573207 V1225108 DKSA S DnaK suppressor protein 11IHW Cluster_473622 V1225110 PLSX map00561,map00564,map01100 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) COG0416 Cluster_473623 V1225111 RPH map00230,map00240,map01100 J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) COG0689 Cluster_473624 V1225112 S NA 0ZN4K Cluster_744767 V1225113 XASA E amino acid COG0531 Cluster_648863 V1225114 MT1052 S Septum formation initiator 1250B Cluster_473625 V1225115 S Membrane 0XQTX Cluster_537325 V1225116 M cell wall-binding protein COG2247 Cluster_497125 V1225117 BL03321 G Major Facilitator COG0477 Cluster_537326 V1225118 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit alpha COG0587 Cluster_473626 V1225119 GLPQ map00564 C glycerophosphoryl diester phosphodiesterase COG0584 Cluster_475757 V1225122 HRPB L ATP-dependent helicase COG1643 Cluster_475758 V1225123 C FMN-binding domain protein COG3976 Cluster_579538 V1225124 FMT S decarboxylase family COG1611 Cluster_475759 V1225125 M Cell wall binding repeat 2-containing protein 12D0J Cluster_809156 V1225126 H thiF family COG0476 Cluster_832262 V1225127 H thiF family COG0476 Cluster_475761 V1225131 YGGP S Rhomboid family COG0705 Cluster_475762 V1225132 THRS map00020,map00300,map00630,map00720,map01100,map01110,map01120,map01210,map01230 C Aconitate hydratase COG1048 Cluster_475763 V1225133 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_734700 V1225134 SUHB G inositol mono-phosphatase COG0483 Cluster_475765 V1225136 V ABC transporter COG1132 Cluster_528845 V1225137 GCDH map00071,map00281,map00310,map00380,map01100,map01110 I Dehydrogenase COG1960 Cluster_475766 V1225138 U, W Pfam:YadA COG5295 Cluster_475767 V1225140 S Protein of unknown function, DUF488 COG5483 Cluster_475768 V1225141 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_540138 V1225143 FEPG map02010 P transport system, permease COG4779 Cluster_475769 V1225144 YHAM S UPF0597 protein COG3681 Cluster_711608 V1225145 RPSS map03010 J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) COG0185 Cluster_475771 V1225147 M peptidase COG0739 Cluster_475772 V1225148 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_475773 V1225149 MT3296 L helicase COG2887 Cluster_520397 V1225152 YDIU S UPF0061 protein COG0397 Cluster_475774 V1225157 S YitT family COG1284 Cluster_475775 V1225158 S NA 0ZJ1F Cluster_728173 V1225159 PVDS map00190,map03018 L polyphosphate kinase 2 COG2326 Cluster_475776 V1225160 GLVC map00010,map02060 G PTS System COG1264 Cluster_678615 V1225161 PURC map00230,map01100,map01110 F SAICAR synthetase COG0152 Cluster_475777 V1225163 M Cell wall associated biofilm protein COG1404 Cluster_475778 V1225164 S Membrane COG3949 Cluster_475779 V1225165 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_477961 V1225166 HSDM V N-6 DNA Methylase COG0286 Cluster_475780 V1225167 SHC P drug resistance transporter, EmrB QacA subfamily 0XNN3 Cluster_477962 V1225168 NIRK map00910,map01120 Q nitrite reductase COG2132 Cluster_477963 V1225169 ASPB K Transcriptional regulator COG1167 Cluster_477964 V1225171 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG1754 Cluster_728174 V1225172 DCTP C symporter COG1301 Cluster_475781 V1225176 S NA COG4694 Cluster_731484 V1225177 QCRA map00190,map00910,map01100,map02020,map04260,map05010,map05012,map05016 C c reductase, iron-sulfur COG0723 Cluster_758517 V1225178 QCRC map00190,map01100 C cytochrome C COG2010 Cluster_661297 V1225179 S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) COG2128 Cluster_475782 V1225181 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_762278 V1225182 RPLV map03010 J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) COG0091 Cluster_731485 V1225183 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_632883 V1225185 V restriction endonuclease COG4127 Cluster_728175 V1225188 RFBD map02010 V (ABC) transporter COG1682 Cluster_789248 V1225189 RFBE map02010 P abc transporter COG1134 Cluster_621560 V1225191 D ftsk SpoIIIE family protein COG1674 Cluster_610471 V1225194 S NA 124KR Cluster_674180 V1225197 YCEA J UPF0176 protein COG1054 Cluster_836152 V1225198 BMUL_4367 L DNA binding domain protein, excisionase family 177Y1@proNOG Cluster_477967 V1225200 M NA 100GX Cluster_692112 V1225201 ANT_21350 E DNA-binding protein COG2856 Cluster_748113 V1225203 S Membrane 0Y2N2 Cluster_576434 V1225205 MCBR K Transcriptional regulator 11WG2 Cluster_744768 V1225208 TATD L Hydrolase, tatD family COG0084 Cluster_599626 V1225212 ALKA map03410 L 8-oxoguanine DNA glycosylase COG0122 Cluster_534433 V1225213 S domain protein COG3428 Cluster_674181 V1225215 S Membrane COG3949 Cluster_509891 V1225216 MMPL H MMPL domain protein COG2409 Cluster_711609 V1225217 K Transcriptional regulator, arsr family COG0640 Cluster_769976 V1225219 YKFB M mandelate racemase muconate lactonizing COG4948 Cluster_480368 V1225221 P tonB-dependent Receptor COG1629 Cluster_477969 V1225222 LPD map00010,map00020,map00260,map00280,map00620,map01100,map01110,map01120 C dihydrolipoyl dehydrogenase COG1249 Cluster_477970 V1225223 S Membrane 0ZTTH Cluster_480369 V1225224 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_836153 V1225227 M hydrolase COG3409 Cluster_480370 V1225228 S NA 0XNWW Cluster_480371 V1225229 V Restriction modification system DNA specificity domain protein COG0732 Cluster_480372 V1225231 RFBD map00521,map00523,map01100,map01110 M Dtdp-4-dehydrorhamnose reductase COG1898 Cluster_520398 V1225232 DCP E oligopeptidase A COG0339 Cluster_480373 V1225233 K Transcriptional regulator, TetR family COG1309 Cluster_520399 V1225234 FEAB map00010,map00040,map00053,map00071,map00250,map00280,map00310,map00330,map00340,map00350,map00360,map00380,map00410,map00561,map00620,map00624,map00625,map00640,map00643,map00650,map00903,map01100,map01110,map01120 C Aldehyde dehydrogenase COG1012 Cluster_480374 V1225236 S NA 0YDU4 Cluster_480375 V1225237 CAT1 map00281,map00620,map00626,map01110,map01120 C Transferase COG0427 Cluster_705376 V1225239 NTH map03410 L endonuclease III COG0177 Cluster_480376 V1225240 S Inherit from COG: ATPase (AAA COG1373 Cluster_480377 V1225241 CAS3 L CRISPR-associated helicase, cas3 COG1203 Cluster_566914 V1225242 MRED M Rod shape-determining protein MreD 0Y74T Cluster_669777 V1225244 V HNH endonuclease 11KD8 Cluster_523169 V1225246 MURE map00300,map00550 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_480378 V1225247 M Putative cell wall binding repeat 2 COG2247 Cluster_482680 V1225248 ENTC map00130,map01053,map01100,map01110 H Isochorismate synthase COG1535 Cluster_579540 V1225250 RPSA map00900,map01100,map01110,map03010 J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) COG0539 Cluster_766240 V1225252 MOAC map00790,map01100,map04122 H Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) COG0315 Cluster_545958 V1225253 S Membrane 0Y2S9 Cluster_721557 V1225254 FADD3 map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG1022 Cluster_480379 V1225256 CSN1 L CRISPR-associated protein, Csn1 family COG3513 Cluster_482681 V1225257 MT3945 map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase 11PV4 Cluster_480380 V1225258 RES V Type III COG3587 Cluster_482682 V1225262 FPRA map00250,map00910,map01100,map01110,map01120,map01230 C reductase COG0493 Cluster_480381 V1225263 MNHD P subunit D COG0651 Cluster_482683 V1225264 TRPE map00400,map01100,map01110,map01230 E anthranilate synthase component I COG0147 Cluster_585960 V1225265 MUTT L hydrolase COG0494 Cluster_669778 V1225266 S Abortive infection protein AbiGI 11WH3 Cluster_515171 V1225267 BIOA map00780,map01100 H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) COG0161 Cluster_515172 V1225268 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_482684 V1225269 S Rib/alpha-like repeat 10008 Cluster_482685 V1225270 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_482687 V1225273 PEPN map00480,map01100 E aminopeptidase N COG0308 Cluster_482688 V1225274 S NA 0Z0R9 Cluster_621561 V1225275 S NA 12481 Cluster_509892 V1225276 VIRB10 map03070,map05120 U type IV secretion system protein VirB10 COG2948 Cluster_482689 V1225277 FUMC map00020,map00720,map01100,map01110,map01120,map05200,map05211 C fumarate hydratase class II COG0114 Cluster_482690 V1225278 FAS map00061,map01100 I fatty acid synthase COG4982 Cluster_793031 V1225282 map00330,map00360,map00380,map00627,map00643,map01120 C Acetamidase formamidase COG2421 Cluster_485004 V1225283 S Dehydrogenase 17GB8@proNOG Cluster_485005 V1225284 Q Nonribosomal peptide synthase COG1020 Cluster_482691 V1225285 O OsmC family COG1073 Cluster_528846 V1225286 D replication-associated protein COG1192 Cluster_585961 V1225287 GSPG map02020,map03070,map05111 U secretion pathway protein COG2165 Cluster_714981 V1225288 K Transcriptional regulator 0XUC3 Cluster_793032 V1225289 S Protein of unknown function (DUF541) 0YM36 Cluster_714982 V1225290 S NA 0YS1M Cluster_482692 V1225291 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_766241 V1225292 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_494621 V1225295 L Integrase, catalytic region COG2801 Cluster_875940 V1225298 CMK map00240,map00410,map00770,map01100,map01110 F Cytidine monophosphate kinase COG0283 Cluster_485007 V1225299 C FMN-binding domain protein COG3976 Cluster_482693 V1225300 DESPR_0182 S NA 16RTH@proNOG Cluster_520400 V1225302 SAFC map00340,map00350,map00624,map01120 S O-methyltransferase COG4122 Cluster_485008 V1225303 HEPA L Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) COG0553 Cluster_482695 V1225304 WBPC I Acyl-transferase COG1835 Cluster_482696 V1225305 PIPD E Dipeptidase COG4690 Cluster_621562 V1225307 RPLV map03010 J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) COG0091 Cluster_482698 V1225308 T response regulator COG2197 Cluster_758518 V1225309 map02010 P cobalt transport COG0619 Cluster_738038 V1225310 YKOD map02010 P ABC transporter COG1122 Cluster_485009 V1225311 map01054 Q synthetase COG1020 Cluster_489638 V1225312 SP_1235 L Nudix family COG0494 Cluster_773655 V1225314 PURK map00230,map01100,map01110 F phosphoribosylaminoimidazole carboxylase atpase subunit COG0026 Cluster_805115 V1225315 BUDA map00650,map00660 Q Alpha-acetolactate decarboxylase COG3527 Cluster_485011 V1225316 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_485012 V1225319 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_554787 V1225320 AGCS E amino acid carrier protein COG1115 Cluster_485013 V1225322 PURF map00230,map00250,map01100,map01110 F glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_485014 V1225323 PROTEASE map05120 O peptidase, U32 COG0826 Cluster_485015 V1225325 ISPG map00900,map01100,map01110 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) COG0821 Cluster_487280 V1225328 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_487281 V1225330 AHCY map00270,map01100 H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) COG0499 Cluster_665467 V1225331 LPQC Q polyhydroxybutyrate depolymerase COG3509 Cluster_665468 V1225333 NAGD map00627,map01120 G had-superfamily hydrolase, subfamily iia COG0647 Cluster_702283 V1225334 C alcohol dehydrogenase COG0604 Cluster_699206 V1225338 SPPA O, U Signal peptide peptidase, SppA COG0616 Cluster_824722 V1225339 YTEJ S rdd domain containing protein COG1714 Cluster_614126 V1225340 S Membrane 126K4 Cluster_569992 V1225344 L DNA Methylase COG2189 Cluster_487282 V1225345 map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_721558 V1225347 L Inherit from COG: transposase COG3666 Cluster_485018 V1225349 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_487284 V1225351 SELB map00450,map00970 J Selenocysteine-specific translation elongation factor COG3276 Cluster_487285 V1225352 CAS5E L crispr-associated protein 11JEJ Cluster_487286 V1225356 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_487287 V1225357 S Abortive infection protein 11MHZ Cluster_487288 V1225358 DPRE1 C FAD linked oxidase domain protein COG0277 Cluster_487289 V1225359 map00010,map00620,map00640,map00680,map00720,map01053,map01100,map01110,map01120 Q synthetase COG0318 Cluster_487290 V1225360 L DNA polymerase 0Y9P0 Cluster_805116 V1225366 ARGB map00330,map01100,map01110,map01210,map01230 E nag kinase COG0548 Cluster_487292 V1225368 RV3193C S UPF0182 protein COG1615 Cluster_652943 V1225369 YHJD S ribonuclease COG1295 Cluster_851775 V1225371 YQHA G aldose 1-epimerase COG2017 Cluster_487294 V1225372 V Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) COG1136 Cluster_487295 V1225374 S NA 17MJM@proNOG Cluster_551917 V1225375 M Nucleoside-diphosphate-sugar pyrophosphorylase 0ZRVF Cluster_851776 V1225377 S recb family COG2251 Cluster_751532 V1225378 S NA 11TZ3 Cluster_554788 V1225379 C Monooxygenase COG2141 Cluster_487297 V1225380 L TrwC relaxase COG0507 Cluster_489639 V1225381 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_636917 V1225382 M Inherit from NOG: glycosyl transferase group 1 0XT85 Cluster_674183 V1225383 TEX K domain protein COG2183 Cluster_487298 V1225385 S integral membrane protein COG0628 Cluster_754990 V1225391 LBUC_0165 L Integrase COG2826 Cluster_487299 V1225392 DPPA map02010 E ABC transporter substrate-binding protein COG4166 Cluster_606807 V1225394 MT0425 S secreted protein 10SG5 Cluster_489640 V1225395 SRTB M (sortase) family COG3764 Cluster_687585 V1225397 NTH map03410 L endonuclease III COG0177 Cluster_489641 V1225399 LIPS2 map00561,map01100 S Secretory lipase 0YTM1 Cluster_489642 V1225403 V abc transporter permease protein COG0577 Cluster_489643 V1225404 K RNA polymerase sigma-24 subunit, ECF subfamily 11RT3 Cluster_515173 V1225405 PKND E ABC transporter substrate-binding protein COG0834 Cluster_636918 V1225409 OPCA G OpcA protein COG3429 Cluster_540139 V1225410 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins COG0706 Cluster_489645 V1225412 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_781119 V1225413 P Chromate transport protein COG2059 Cluster_714983 V1225414 P Chromate transport protein COG2059 Cluster_512470 V1225415 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_512471 V1225416 L integrase family 0XRS7 Cluster_718231 V1225417 MANA map00051,map00520,map01100,map01110 G mannose-6-phosphate isomerase COG1482 Cluster_489646 V1225418 ZUPT P Mediates zinc uptake. May also transport other divalent cations (By similarity) COG0428 Cluster_534434 V1225423 S Pfam:YadA 0YNSE Cluster_489647 V1225424 S ATP GTP-binding protein 0XNYD Cluster_489648 V1225425 U, W Pfam:Hep_Hag COG5295 Cluster_762279 V1225427 YHJD S ribonuclease COG1295 Cluster_489650 V1225429 MYCA S Myosin-Cross-Reactive Antigen COG4716 Cluster_543020 V1225430 RBSK map00030 G ribokinase COG0524 Cluster_492136 V1225431 M NA 0ZTFU Cluster_499783 V1225433 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_489651 V1225434 P Sodium hydrogen exchanger 0ZT2S Cluster_492137 V1225436 POLA_2 L DNA polymerase 0XRUF Cluster_492138 V1225438 Y2367 P integral membrane protein COG4393 Cluster_820735 V1225439 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_888065 V1225441 CG2428 S rdd domain containing protein 11WIF Cluster_669779 V1225442 RV2219 S integral membrane protein 0Z3WW Cluster_687586 V1225443 NIMB S Resistance protein COG3467 Cluster_492140 V1225444 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_489652 V1225445 S Lpxtg-motif cell wall anchor domain protein 0XQBH Cluster_489653 V1225447 ARSB P arsenicaL-resistance protein COG0798 Cluster_492142 V1225450 S Inherit from NOG: Ribosomal protein 1272F Cluster_832263 V1225454 G Major facilitator superfamily MFS_1 11MD0 Cluster_492144 V1225457 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_492145 V1225459 AMIB map00360 E amidohydrolase COG1473 Cluster_492146 V1225460 S UPF0232 protein COG5512 Cluster_537327 V1225461 DAPC map00300,map01100,map01120,map01230 E Aminotransferase COG0436 Cluster_492147 V1225465 AMPG2 E, G, P Beta-lactamase induction signal transducer COG0477 Cluster_683155 V1225470 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_492148 V1225471 YCIC S cobalamin synthesis protein P47K COG0523 Cluster_629059 V1225472 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_840029 V1225474 S NA 0YUW4 Cluster_492149 V1225475 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_705378 V1225477 ARGR K Regulates arginine biosynthesis genes (By similarity) COG1438 Cluster_816923 V1225478 ARGF map00330,map01100,map01110,map01230 E ornithine carbamoyltransferase COG0078 Cluster_537328 V1225479 SP_0341 S UPF0371 protein COG4868 Cluster_589281 V1225481 S membrane protein, AbrB duplication COG3180 Cluster_859562 V1225482 S (LipO)protein 0Z2QG Cluster_731486 V1225483 S (LipO)protein 0Z2QG Cluster_683156 V1225485 SSEA map00270,map01100,map04122 P sulfurtransferase COG2897 Cluster_582777 V1225487 YBAK S YbaK ebsC protein COG2606 Cluster_754991 V1225488 PUTP E Sodium proline symporter COG0591 Cluster_606808 V1225491 THRC map00260,map00750,map01100,map01120,map01230 E threonine synthase COG0498 Cluster_566915 V1225493 MEGL map00260,map00270,map00450,map00920,map01100,map01110,map01230 E Cystathionine gamma-synthase COG0626 Cluster_515174 V1225495 map02010 P ABC transporter COG1108 Cluster_528847 V1225497 S Nadph-dependent fmn reductase COG0431 Cluster_494623 V1225498 T Histidine kinase 11MGX Cluster_494624 V1225499 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_614127 V1225500 K Transcriptional regulator COG0583 Cluster_492152 V1225501 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_494625 V1225502 V transporter, permease 10BP7 Cluster_494626 V1225503 LMRA map02010 V abc transporter COG1132 Cluster_494627 V1225504 ABGT H Transporter COG2978 Cluster_494628 V1225505 S Family of unknown function (DUF490) 0XPFA Cluster_828543 V1225506 RSMI G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 Cluster_875944 V1225507 PMT M glycosyl transferase, family 39 COG1928 Cluster_494629 V1225508 LYSA map00300,map01100,map01110,map01120,map01230 E decarboxylase COG4529 Cluster_494630 V1225509 S Cutinase 0YUSA Cluster_494631 V1225510 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_494632 V1225511 MOEA H molybdopterin biosynthesis protein COG0303 Cluster_751533 V1225513 S membrAne 0XRY9 Cluster_844090 V1225514 S phage protein 0XQDU Cluster_497126 V1225517 V abc transporter permease protein 0XQE2 Cluster_494633 V1225518 MGTE P MgtE intracellular region COG2239 Cluster_517850 V1225519 S NA 11V19 Cluster_705379 V1225522 HSDR V Type I Restriction COG0610 Cluster_497128 V1225526 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_579541 V1225528 SURB S G5 domain protein 0ZVV3 Cluster_724907 V1225529 SP_1215 P transporter COG2116 Cluster_744769 V1225530 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_777376 V1225531 THIL map00730,map01100 H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) COG0611 Cluster_497129 V1225532 MURE map00300,map00550 M mur ligase COG0769 Cluster_497130 V1225536 FARR K gntR family transcriptional regulator COG2188 Cluster_497131 V1225537 RFE M Glycosyl transferase, family 4 COG0472 Cluster_632885 V1225538 RSEP map04112 M Membrane-associated zinc metalloprotease COG0750 Cluster_497132 V1225539 ALST E amino acid carrier protein COG1115 Cluster_669780 V1225543 RNHB map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0164 Cluster_863897 V1225544 LEPB map03060 U Signal peptidase i COG0681 Cluster_678616 V1225547 DNAE2 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase (By similarity) COG0587 Cluster_497134 V1225550 AMIA map00360 E amidohydrolase COG1473 Cluster_497135 V1225551 M lysozyme COG3757 Cluster_497136 V1225552 SRTA M (sortase) family COG3764 Cluster_497137 V1225553 GLNH map02010,map02020 E, T (ABC) transporter COG0834 Cluster_497138 V1225554 map02010 V ABC transporter COG1132 Cluster_762280 V1225555 SP_0561 S Domain of unknown function (DUF1858) 1243S Cluster_497140 V1225559 TRAA L TrwC relaxase COG0507 Cluster_708469 V1225563 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_728177 V1225564 CAT map00281,map00620,map00626,map01110,map01120 C Transferase COG0427 Cluster_499785 V1225566 L Virulence-associated protein e COG5545 Cluster_497143 V1225569 S NA 0ZDF1 Cluster_499786 V1225574 AROA map00400,map00401,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate synthase COG0128 Cluster_692113 V1225575 YHAI S membrAne COG3152 Cluster_629060 V1225578 S NA 11HQF Cluster_499787 V1225579 V restriction enzyme COG1002 Cluster_497148 V1225585 HUTI map00340,map01100 Q imidazolone-5-propionate hydrolase COG1228 Cluster_499788 V1225586 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG2812 Cluster_499789 V1225587 MNAA map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_766242 V1225590 GLPF G glycerol uptake facilitator protein COG0580 Cluster_758519 V1225592 RIBD map00740,map01100 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) COG1985 Cluster_728178 V1225595 MT3693 S secreted protein 11ZB4 Cluster_499790 V1225596 DEAD map03018 L ATP-dependent RNA helicase COG0513 Cluster_499791 V1225597 S NA 11HZH Cluster_576436 V1225598 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_499792 V1225599 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_499793 V1225600 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_665469 V1225601 RND J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) COG0349 Cluster_888068 V1225602 SCLAV_4848 S Protein of unknown function (DUF3000) 11PF6 Cluster_499794 V1225605 FTSX map02010 D Part of the ABC transporter FtsEX involved in cellular division (By similarity) COG2177 Cluster_585963 V1225608 YCHF J gtp-binding protein COG0012 Cluster_789249 V1225610 S Inherit from COG: Conserved protein COG4804 Cluster_499795 V1225611 GLCD map00620,map00630,map01100,map01110,map01120 C FAD linked oxidase domain-containing protein COG0277 Cluster_557702 V1225612 S methyltransferase 0ZVPT Cluster_499796 V1225613 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG1372 Cluster_805121 V1225615 LEGAS_1040 L transposase COG2963 Cluster_499798 V1225618 ICD map00020,map00480,map00720,map01100,map01110,map01120,map01210,map01230,map04146 C Isocitrate dehydrogenase COG2838 Cluster_499799 V1225620 CMEB V Multi-drug resistance protein COG0841 Cluster_708470 V1225621 BMUL_6032 K iclR family transcriptional regulator COG1414 Cluster_569994 V1225623 S NA 0YHQV Cluster_540140 V1225624 E, G Membrane COG0697 Cluster_863898 V1225625 KDPD map02020 T Osmosensitive K channel His kinase sensor COG2205 Cluster_728179 V1225626 KDPC map02020 P One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) COG2156 Cluster_502319 V1225627 BCRA map02010 V ABC transporter COG1131 Cluster_499800 V1225630 PPC map00620,map00680,map00710,map00720,map01100,map01120 C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) COG2352 Cluster_599628 V1225632 YQEV J MiaB-like tRNA modifying enzyme COG0621 Cluster_592632 V1225633 MT3543 S NA 11ISP Cluster_610472 V1225634 QCRA P rieske 2fe-2S domain-containing protein COG2146 Cluster_773656 V1225636 V N-6 DNA Methylase COG0286 Cluster_741455 V1225637 V Restriction modification system DNA specificity COG0732 Cluster_528848 V1225638 ANSA map00250,map00460,map00910,map01100,map01110 E L-asparaginase COG0252 Cluster_796986 V1225639 ARCD E Arginine ornithine antiporter COG0531 Cluster_769978 V1225640 HSPR K merR family transcriptional Regulator COG0789 Cluster_762282 V1225642 GCDH map00071,map00281,map00310,map00380,map01100,map01110 I Dehydrogenase COG1960 Cluster_502321 V1225644 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_629061 V1225645 MDH map00020,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120 C Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) COG0039 Cluster_644805 V1225646 GBRO_0040 L Transposase COG3464 Cluster_502322 V1225647 S Rib/alpha-like repeat 10008 Cluster_502323 V1225649 AARI_34870 L transposase of ISAar22, IS481 family COG2801 Cluster_499801 V1225650 S domain protein 11GX7 Cluster_502324 V1225651 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_499802 V1225652 PTSG map00010,map00500,map00520,map02060 G PTS system COG2190 Cluster_867902 V1225653 S NA 0ZIRI Cluster_502325 V1225654 S hmm pf04634 0Y5PY Cluster_502326 V1225656 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_499803 V1225657 XTH map03410 L Exodeoxyribonuclease III COG0708 Cluster_502328 V1225660 V Beta-lactamase 0ZWUI Cluster_502329 V1225661 SDRA V type iii restriction COG1061 Cluster_502330 V1225663 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_540141 V1225664 HEMG map00860,map01100,map01110 H protoporphyrinogen oxidase COG1232 Cluster_502331 V1225666 S NA 0Z6CP Cluster_640944 V1225668 GCDH map00071,map00310,map00380,map01100 I Dehydrogenase COG1960 Cluster_683157 V1225669 PFLA O Pyruvate formate-lyase COG1180 Cluster_606810 V1225670 RPE map00030,map00040,map00710,map01100,map01110,map01120,map01230 G ribulose-phosphate 3-epimerase COG0036 Cluster_537329 V1225671 L rad52 22 double-strand break repair protein COG4712 Cluster_563718 V1225672 S NA 0YTJD Cluster_859563 V1225673 PPX map00230 F, P ppx gppa phosphatase COG0248 Cluster_731487 V1225674 MT1053 D Septum formation initiator family protein COG1507 Cluster_502332 V1225675 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_636919 V1225676 MOD map00340,map00350,map00624,map01120 L DNA methylase COG2189 Cluster_502334 V1225678 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01230 G phosphohexose isomerase COG0166 Cluster_502335 V1225679 SUHB G inositol mono-phosphatase COG0483 Cluster_657071 V1225681 GAP map00010,map01100,map01110,map01120,map01230,map04066,map05010 G Glyceraldehyde-3-phosphate dehydrogenase COG0057 Cluster_502336 V1225682 RV1842C P integral membrane protein COG1253 Cluster_840030 V1225683 DCTP C symporter COG1301 Cluster_502337 V1225685 M Inherit from COG: YD repeat protein COG3209 Cluster_504727 V1225692 MURI map00471,map01100 M Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) COG0796 Cluster_687588 V1225693 PSTS map02010,map02020,map05152 P Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) COG0226 Cluster_582778 V1225694 ASP S Alkaline-shock protein COG1302 Cluster_502338 V1225695 M Cell wall binding repeat 2-containing protein COG2247 Cluster_554789 V1225696 VIRB4 map03070,map05120 U conjugal transfer ATPase COG3451 Cluster_773657 V1225698 S NA 11KAE Cluster_652945 V1225700 TNP L transposase COG1943 Cluster_665470 V1225701 S NA 0ZGW5 Cluster_777377 V1225704 P periplasmic solute binding protein COG0803 Cluster_504728 V1225705 TETB map02010 V ABC transporter COG1132 Cluster_502339 V1225707 ELRF S cutinase 11FQ6 Cluster_502340 V1225708 S NA 0ZHVH Cluster_504729 V1225711 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_545960 V1225713 RIMP S Required for maturation of 30S ribosomal subunits (By similarity) COG0779 Cluster_502341 V1225714 PSAA map02010 P ABC transporter COG0803 Cluster_648864 V1225715 S Domain of unknown function (DUF1896) 0ZYCY Cluster_636920 V1225716 map02020 T Two component transcriptional regulator (Winged helix family COG0745 Cluster_504732 V1225718 DGT map00230 F deoxyguanosinetriphosphate triphosphohydrolase-like protein COG0232 Cluster_504733 V1225719 SIDE P Siderophore-interacting protein COG2375 Cluster_504734 V1225720 U, W Pfam:Hep_Hag COG5295 Cluster_793035 V1225721 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_820736 V1225722 GPSA map00564 C NADPH-dependent glycerol-3-phosphate dehydrogenase COG0240 Cluster_504735 V1225723 DAPA map00300,map01100,map01110,map01120,map01230 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) COG0329 Cluster_504736 V1225725 K transcriptional regulator, merr family COG0789 Cluster_678617 V1225727 PSTS map02010,map02020,map05152 P phosphate abc transporter COG0226 Cluster_504737 V1225728 P tonB-dependent Receptor COG4771 Cluster_504738 V1225730 PEPF map04614,map05143 E Oligoendopeptidase f COG1164 Cluster_589282 V1225731 HSDS V restriction COG0732 Cluster_661298 V1225732 NTPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_504739 V1225733 RES_1 V type IIi COG3421 Cluster_507301 V1225734 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (Alpha subunit) COG0587 Cluster_523170 V1225735 GRAS map02020 T Histidine kinase COG0642 Cluster_504740 V1225736 PRIA map03440 L Primosomal protein n' COG1198 Cluster_507302 V1225737 NIFJ map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map00910,map01100,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_504741 V1225738 CSGG M Curli production assembly transport component CsgG COG1462 Cluster_504742 V1225740 RIBF map00740,map01100 H riboflavin biosynthesis protein ribF COG0196 Cluster_504743 V1225741 map00550,map01100 M glycosyl transferase, family 51 COG0744 Cluster_652946 V1225742 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_683158 V1225744 RV2927C D growth COG3599 Cluster_896312 V1225745 GDHA map00250,map00330,map00910,map01100 E Glutamate dehydrogenase COG0334 Cluster_504744 V1225746 LLDP C L-lactate COG1620 Cluster_507303 V1225748 S NA 0ZWIA Cluster_507304 V1225749 map00561,map01100 G Dihydroxyacetone kinase COG2376 Cluster_504746 V1225751 S NA 11G18 Cluster_507305 V1225752 SCLAV_3021 S (twin-arginine translocation) pathway signal COG3211 Cluster_515175 V1225755 S Inherit from COG: Involved in the degradation of specific anti-sigma factors (By similarity) COG2339 Cluster_504747 V1225756 LYTR1 K TRANSCRIPTIONal COG1316 Cluster_504748 V1225757 M Inherit from NOG: Polymorphic outer membrane protein 11KKP Cluster_504749 V1225758 S Phage infection protein COG1511 Cluster_507307 V1225759 PKS13 Q PKS_AT COG3321 Cluster_741456 V1225762 CUTA S divalent ion tolerance protein COG3323 Cluster_504750 V1225763 PARC L Dna topoisomerase iv (Subunit a) COG0188 Cluster_603200 V1225764 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_507309 V1225768 MUIA S Inherit from NOG: protein binding 0XS0N Cluster_758520 V1225769 U, W Pfam:YadA COG5295 Cluster_504751 V1225770 K Transcriptional regulator, GntR family COG1167 Cluster_793036 V1225771 KDSA map00540,map01100 M Phospho-2-dehydro-3-deoxyoctonate aldolase COG2877 Cluster_507310 V1225772 S NA 12A8F Cluster_695927 V1225775 S NA 12CWM Cluster_507312 V1225779 RV3778C map00730,map04122 E cysteine desulfurase family protein COG0520 Cluster_832266 V1225781 RUBR C rubredoxin COG1773 Cluster_614129 V1225784 map02010 P ABC transporter COG1108 Cluster_734701 V1225785 S NA 0ZHU9 Cluster_507313 V1225786 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_507314 V1225787 USPA4 T Universal stress protein COG0589 Cluster_665471 V1225788 RV0883C S dNA-binding protein 0XSMI Cluster_884158 V1225789 S NA 12B83 Cluster_836155 V1225790 XIS S DNA binding domain protein, excisionase family 121Y0 Cluster_507315 V1225791 map02010 S ABC transporter COG1123 Cluster_507316 V1225793 C FMN-binding domain protein COG3976 Cluster_507317 V1225794 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_507318 V1225795 TOPB L Dna topoisomerase COG0551 Cluster_507319 V1225796 S NA 0XNRI Cluster_928904 V1225797 AROG map00400,map01100,map01110,map01230 E phospho-2-dehydro-3-deoxyheptonate aldolase COG3200 Cluster_183648 V1022408 V Inherit from COG: Type II restriction enzyme, methylase COG1002 Cluster_389066 V1022410 S Membrane 11TU2 Cluster_289769 V1022411 S NA 0YA5G Cluster_292372 V1022412 MENB map00130,map01100,map01110 H Naphthoate synthase COG0447 Cluster_184522 V1022413 S ABC transporter, ATPase COG3044 Cluster_218223 V1022420 YGHZ map00051,map00363,map00591,map00625,map00650,map01100,map01120 C Oxidoreductase, aldo keto reductase family COG0667 Cluster_419287 V1022422 RSFS S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) COG0799 Cluster_620753 V1022423 CPIN_3686 L Transposase (IS4 family COG3385 Cluster_494052 V1022429 map02010,map02020,map05152 P phosphate abc transporter COG0226 Cluster_792166 V1022431 HFLX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COG2262 Cluster_491595 V1022432 GPO map00480,map00590 O Glutathione peroxidase COG0386 Cluster_333244 V1022434 ACTP P p-type atpase COG2217 Cluster_346978 V1022439 S NA 11M0J Cluster_823822 V1022441 S Tetratricopeptide repeat protein COG0457 Cluster_695144 V1022443 YBET S Sel1 domain protein repeat-containing protein COG0790 Cluster_757741 V1022445 ILVB map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E acetolactate synthase large subunit COG0028 Cluster_281469 V1022447 map00361,map00625,map01100,map01120 S Alpha beta hydrolase COG0596 Cluster_380176 V1022450 SGLY_0535 S phage protein 0XNW6 Cluster_533763 V1022451 S Putative ATPase subunit of terminase (gpP-like) 0Z1RP Cluster_364938 V1022452 EMBC M Arabinosyltransferase 0XSQE Cluster_313431 V1022455 ASD map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) COG0136 Cluster_695145 V1022456 S Toxin-antitoxin system, toxin component, RelE family COG4680 Cluster_635916 V1022459 S metallophosphoesterase 0XQXV Cluster_799912 V1022460 map00500,map01100 G glycoside hydrolase 15-related COG3387 Cluster_340739 V1022461 LIVF map02010 E ABC, transporter COG0410 Cluster_754166 V1022465 S Acyl carrier protein 12BHR Cluster_517244 V1022467 FAHA Q 5-carboxymethyl-2-hydroxymuconate Delta-isomerase (EC 5.3.3.10) COG0179 Cluster_743931 V1022468 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_189730 V1022471 S NA 0YAQZ Cluster_588482 V1022475 S Protein of unknown function (DUF3147) 129B9 Cluster_383741 V1022478 PGLC M Bacterial sugar transferase COG2148 Cluster_446575 V1022479 S Possible lysine decarboxylase COG1611 Cluster_419288 V1022481 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_190613 V1022482 YQFF S Metal Dependent Phosphohydrolase COG1480 Cluster_740688 V1022484 S heparinase II III family protein 0XR1B Cluster_190615 V1022487 MTR map00010,map00020,map00260,map00280,map00480,map00620,map01100,map01110,map01120 C pyridine nucleotide-disulfide oxidoreductase COG1249 Cluster_730729 V1022492 S ATPase (AAA COG1373 Cluster_509301 V1022493 PITB P phosphate COG0306 Cluster_686562 V1022494 AMPG2 E, G, P Beta-lactamase induction signal transducer COG0477 Cluster_519824 V1022495 L ATP-dependent endonuclease of the OLD COG3593 Cluster_311981 V1022499 YFJF G drug resistance transporter 0XNN3 Cluster_724158 V1022501 S NA 17A1P@proNOG Cluster_191501 V1022503 RECG map03420,map03440 L transcriptioN-repair coupling factor COG1197 Cluster_330210 V1022504 S metallophosphoesterase 0XQXV Cluster_219436 V1022505 PEPN_1 E Peptidase M1 membrane alanine aminopeptidase COG0308 Cluster_324231 V1022506 map04112 L Modification (Methylase) 17BB8@proNOG Cluster_660322 V1022507 S NA 0YJH5 Cluster_238356 V1022508 S Membrane 11QY1 Cluster_585220 V1022510 S Staphylococcal nuclease homologue 128V1 Cluster_496546 V1022511 LUXS map00270,map05111 T Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) COG1854 Cluster_299216 V1022514 S Uncharacterized conserved protein (DUF2075) 0XPB6 Cluster_192444 V1022516 D Chromosome segregation protein SMC COG1196 Cluster_258821 V1022517 LPQB S lipoprotein lpqB 11S85 Cluster_652006 V1022520 GLTT C sodium dicarboxylate symporter COG1301 Cluster_423005 V1022521 MT2318 V Beta-lactamase COG1680 Cluster_291048 V1022522 CYSL K LysR family (Transcriptional regulator COG0583 Cluster_374957 V1022523 RPLC map03010 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 Cluster_193280 V1022524 S NA 0YB2E Cluster_397954 V1022525 AASI_0458 S WbqC-like 0ZW99 Cluster_309021 V1022526 ASPC map00250,map00290,map01100,map01110,map01210,map01230 E Aminotransferase COG0436 Cluster_194235 V1022529 CADA P heavy metal translocating p-type ATPase COG2217 Cluster_254999 V1022536 C, G Glycosyltransferase COG1819 Cluster_353446 V1022541 S Phage nucleotide-binding protein 0YG3Q Cluster_628195 V1022542 LGAS_0604 V Hnh endonuclease 0XUCJ Cluster_364939 V1022543 S NA 11EJC Cluster_717500 V1022544 G phosphocarrier protein (HPr) COG1925 Cluster_717501 V1022546 BPH3 S histone family protein nucleoid-structuring protein h-ns COG2916 Cluster_557014 V1022547 RBSD map02010 G Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) COG1869 Cluster_248824 V1022548 S WD40-like beta Propeller containing protein 0YCAG Cluster_195124 V1022549 T ATPase histidine kinase DNA gyrase B HSP90 domain protein 0XNMH Cluster_602324 V1022550 YIBL S Protein of unknown function (DUF2810) 17ACD@proNOG Cluster_827726 V1022552 SCLAV_2642 S Lipase esterase 11GU9 Cluster_432575 V1022553 PDXT map00750 H Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) COG0311 Cluster_477457 V1022554 RV0561C map00860,map00900,map01100,map01110 C geranylgeranyl reductase COG0644 Cluster_287058 V1022555 RNHA map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0328 Cluster_470995 V1022557 K RNA Polymerase COG1595 Cluster_195975 V1022559 S NA 0ZTYV Cluster_345420 V1022561 PHOP map02020 T Alkaline phosphatase synthesis transcriptional regulatory protein COG0745 Cluster_796112 V1022562 PHOR map02020 T Histidine kinase 0XNMH Cluster_195976 V1022568 S Inherit from COG: Virulence-associated protein e COG4983 Cluster_196796 V1022571 L Phage terminase, large subunit COG1783 Cluster_381957 V1022574 S NA 11R7X Cluster_545245 V1022575 K RNA polymerase 11UU1 Cluster_310436 V1022576 S NA 11TZ3 Cluster_468889 V1022580 ELAA S gCN5-related N-acetyltransferase COG2153 Cluster_197699 V1022581 PLPD S Patatin-like phospholipase COG1752 Cluster_197700 V1022584 P tonB-dependent Receptor 0XNN9 Cluster_299217 V1022585 IDNO S oxidoreductase, short chain dehydrogenase reductase family protein 0XNW1 Cluster_499201 V1022587 MOD map00340,map00350,map00624,map01120 L DNA methylase COG2189 Cluster_591856 V1022588 RV3669 S Membrane 11U4P Cluster_399650 V1022591 MT1668 S Protein of unknown function (DUF402) COG2306 Cluster_557015 V1022592 S Suppressor of fused protein (SUFU) 11QEC Cluster_668869 V1022593 ORF010 S Staphylococcal protein of unknown function (DUF960) 1265C Cluster_858464 V1022594 CCU S Protein of unknown function (DUF1643) COG4333 Cluster_426669 V1022595 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_197701 V1022596 S 5'-phosphate oxidase COG3576 Cluster_339283 V1022598 S NA 0YZ82 Cluster_198721 V1022599 map00051,map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 G ec 3.2.1.52 COG3525 Cluster_656173 V1022600 H mosc domain containing protein COG2258 Cluster_718234 V1225804 INFA J however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) COG0361 Cluster_509895 V1225805 LHR L helicase COG1201 Cluster_507322 V1225806 P tonB-dependent Receptor 0XP5Y Cluster_599629 V1225807 HIT F, G Histidine triad (HIT) protein COG0537 Cluster_517851 V1225808 TTCA D Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) COG0037 Cluster_632886 V1225810 AFUA map02010 P extracellular solute-binding protein family 1 COG1840 Cluster_509896 V1225811 GLYQS map00970 J Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) COG0423 Cluster_507323 V1225813 NUPC F nucleoside COG1972 Cluster_507324 V1225815 S Calcineurin-like phosphoesterase COG1409 Cluster_507325 V1225816 L transposase IS605 OrfB family 0XT7Q Cluster_507326 V1225817 LYSA map00300,map01100,map01110,map01120,map01230 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) COG0019 Cluster_528849 V1225818 L Transposase 0ZX7U Cluster_515176 V1225819 S GtrA-like protein 0YHT4 Cluster_636921 V1225820 S NA 126GD Cluster_636922 V1225822 MUCPA_0453 L Transposase COG3328 Cluster_636923 V1225825 L Transposase COG3328 Cluster_507328 V1225826 SCLAV_5207 map00300,map00310,map01100,map01110,map01230 S Saccharopine dehydrogenase COG3268 Cluster_738039 V1225829 S Protein of unknown function (DUF3263) 0Z4V3 Cluster_509897 V1225830 L type iii restriction protein res subunit COG3886 Cluster_751535 V1225832 map00564,map00730 C fad dependent oxidoreductase COG0579 Cluster_509899 V1225835 ATPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_762283 V1225836 LEUB map00290,map01100,map01110,map01210,map01230 E Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) COG0473 Cluster_509900 V1225838 THIC map00730,map01100 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) COG0422 Cluster_509901 V1225839 S integral membrane protein COG0628 Cluster_509902 V1225840 HPAF map00350,map01100,map01120 Q Fumarylacetoacetate hydrolase COG0179 Cluster_754995 V1225841 S NA 0ZUS3 Cluster_509903 V1225843 S VanZ like family 0ZZS5 Cluster_640945 V1225844 S NA 186C8@proNOG Cluster_789250 V1225846 S Transmembrane domain of unknown function (DUF3566) 11X32 Cluster_509904 V1225847 S Rib/alpha-like repeat 10008 Cluster_509906 V1225849 V MatE COG0534 Cluster_702286 V1225850 LPLA map00785,map01100 H Lipoate-protein, ligase COG0095 Cluster_632887 V1225851 S Cell wall-associated hydrolase 127G0 Cluster_509908 V1225855 map00051,map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 G Glycosyl hydrolase family 20 COG3525 Cluster_509909 V1225856 L SNF2 family DNA RNA helicase COG0553 Cluster_509910 V1225858 V restriction COG1002 Cluster_576437 V1225860 S cupin domain protein 11XEB Cluster_766246 V1225861 DPPC E, P ABC transporter (permease) COG1173 Cluster_773659 V1225862 DPPB map02010 P Binding-protein-dependent transport systems inner membrane component COG0601 Cluster_509912 V1225865 MODA map02010 P ABC transporter, periplasmic molybdate-binding protein COG0725 Cluster_678619 V1225867 SEPF S Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) COG1799 Cluster_751536 V1225868 S prevent-host-death family 122I4 Cluster_512473 V1225869 AAS map00071,map00564 I 2-acylglycerophosphoethanolamine acyltransferase COG0477 Cluster_828546 V1225870 GLNQ E abc transporter atp-binding protein COG1126 Cluster_718235 V1225871 ARTM2 E amino acid AbC transporter COG0765 Cluster_512474 V1225872 L dEAD DEAH box helicase COG1205 Cluster_603201 V1225878 TNPS L Integrase 0ZQPZ Cluster_509915 V1225879 SDAAA map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase COG1760 Cluster_509916 V1225880 RV2732C S NA 11NRE Cluster_512476 V1225881 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_509917 V1225882 G Glycoside hydrolase family 76 COG4833 Cluster_512477 V1225883 TNPA L transposase COG4644 Cluster_509918 V1225884 GLYQS map00970 J Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) COG0423 Cluster_512479 V1225886 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG0582 Cluster_512480 V1225887 CINA H cina-like protein COG1058 Cluster_640947 V1225888 S NA 0XWI3 Cluster_512481 V1225889 SP_0239 S UPF0210 protein COG2848 Cluster_734703 V1225891 YLXR K Nucleic-acid-binding protein implicated in transcription termination COG2740 Cluster_509919 V1225892 HEMA map00860,map01100,map01110 H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) COG0373 Cluster_512482 V1225893 P phosphate transport regulator COG1392 Cluster_512483 V1225894 COBQ S Glutamine amidotransferase COG3442 Cluster_512485 V1225898 S Pyrogenic exotoxin B 11S8V Cluster_512486 V1225899 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_512487 V1225900 NUCS L Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) COG1637 Cluster_549014 V1225901 LTAE map00260,map01100,map01110,map01120,map01230 E Aldolase COG2008 Cluster_512488 V1225902 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_512489 V1225903 PPK2 L polyphosphate kinase 2 COG2326 Cluster_657072 V1225904 S haloacid dehalogenase-like hydrolase COG0637 Cluster_512490 V1225905 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_863900 V1225907 DINB L Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) COG0389 Cluster_512491 V1225908 S NA 0ZB17 Cluster_537330 V1225910 NDVA V ABC superfamily ATP binding cassette transporter COG1132 Cluster_796988 V1225914 GALE map00052,map00520,map01100,map01110 M udp-glucose 4-epimerase COG1087 Cluster_793038 V1225915 LIGA map03410,map03420,map03430,map03450 L DNA ligase COG1793 Cluster_828547 V1225916 XYLH map00362,map00621,map00622,map01100,map01120 S 4-oxalocrotonate tautomerase COG1942 Cluster_515178 V1225918 SURB S G5 domain protein 0ZVV3 Cluster_512493 V1225921 S Inherit from COG: domain protein COG3942 Cluster_512494 V1225922 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG1754 Cluster_515179 V1225923 SRTC M (sortase) family COG3764 Cluster_800925 V1225924 LDH map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120 C L-Lactate dehydrogenase COG0039 Cluster_603202 V1225925 I Diacylglycerol kinase COG1597 Cluster_621563 V1225927 L helicase COG4646 Cluster_515180 V1225929 TMP1 S NA 10C99 Cluster_512497 V1225930 S Transporter Permease Protein 0ZURF Cluster_777378 V1225931 YCHF J gtp-binding protein COG0012 Cluster_515181 V1225933 TNAA map00350,map00380 E tryptophanase EC 4.1.99.1 COG3033 Cluster_909044 V1225934 RPMJ map03010 J 50S ribosomal protein L36 COG0257 Cluster_515182 V1225936 FRUK map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G 1-phosphofructokinase COG1105 Cluster_657073 V1225937 S VIT family COG1814 Cluster_515183 V1225938 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_738040 V1225940 MT3357 S Possibl zinc metallo-peptidase 11VPR Cluster_515185 V1225943 YICG S Membrane COG2860 Cluster_625344 V1225946 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_669782 V1225949 ARCD E Arginine ornithine antiporter COG0531 Cluster_543022 V1225951 S ybak prolyl-trna synthetase COG3760 Cluster_515186 V1225952 AMIB map00360 E amidohydrolase COG1473 Cluster_512500 V1225953 ICD map00020,map00480,map00720,map01100,map01110,map01120,map01210,map01230,map04146 C Isocitrate dehydrogenase COG2838 Cluster_705380 V1225954 M Cell wall anchor domain protein 11Q8J Cluster_515187 V1225955 S NA 0Y0YS Cluster_766247 V1225956 PANC map00410,map00770,map01100,map01110 H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) COG0414 Cluster_728180 V1225957 THRS map00020,map00300,map00630,map00720,map01100,map01110,map01120,map01210,map01230 C Aconitate hydratase COG1048 Cluster_537331 V1225960 S Thioesterase COG5496 Cluster_515188 V1225961 E amidohydrolase COG1473 Cluster_599630 V1225962 L Pfam:HTH_14 0ZTSF Cluster_515190 V1225964 S NA 0Z3TH Cluster_741458 V1225966 NARB map00630,map00680,map00910,map01100,map01120 C Molydopterin dinucleotide binding domain COG0243 Cluster_515191 V1225968 S Allergen V5 TPX-1 0XUG5 Cluster_515192 V1225969 PACL2 P Atpase, p-type (Transporting), had superfamily, subfamily ic COG0474 Cluster_614130 V1225972 PEPN_1 E Peptidase M1 membrane alanine aminopeptidase COG0308 Cluster_515193 V1225973 MNHD P subunit D COG0651 Cluster_515194 V1225974 E amino acid carrier protein COG1115 Cluster_515195 V1225975 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_617888 V1225977 S Possibl zinc metallo-peptidase COG3824 Cluster_517852 V1225978 GLGX map00500,map01100,map01110 G glycogen debranching enzyme glgx COG1523 Cluster_582779 V1225979 MQO map00620 C malate dehydrogenase (quinone) COG0579 Cluster_515196 V1225980 map03440 K Transcriptional regulator COG2865 Cluster_714984 V1225981 LKTB3 V ABC transporter, ATP-binding protein COG2274 Cluster_515197 V1225982 DSDA map00260 E d-serine deaminase COG3048 Cluster_526094 V1225985 SRTB M (sortase) family COG3764 Cluster_515198 V1225986 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii subunits gamma and tau COG2812 Cluster_636924 V1225988 PYC map00020,map00620,map00720,map01100,map01120,map01230 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) COG1038 Cluster_576438 V1225994 map02010 V abc transporter COG1132 Cluster_515199 V1225995 UUP S Abc transporter COG0488 Cluster_669783 V1225996 RV1636 T UspA domain-containing protein COG0589 Cluster_520401 V1225998 GUAB3 map00230,map00983,map01100,map01110 F Dehydrogenase COG0516 Cluster_592633 V1225999 ZUPT P Mediates zinc uptake. May also transport other divalent cations (By similarity) COG0428 Cluster_517855 V1226001 S NA 0XTEF Cluster_517856 V1226006 SCLAV_3035 S Abi-like protein 11WV5 Cluster_517857 V1226007 CKL_1868 S NA 0XRCN Cluster_517858 V1226008 V Type III COG3587 Cluster_517859 V1226009 K RNA Polymerase 0XWX7 Cluster_517860 V1226010 SP_0885 S domain protein 0XRFP Cluster_731488 V1226011 ELI_3039 K RNA Polymerase 1261F Cluster_517861 V1226012 DKGA C reductase COG0656 Cluster_867903 V1226014 RLUD J Pseudouridine synthase COG0564 Cluster_687589 V1226015 LSPA map03060 M, U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) COG0597 Cluster_517862 V1226017 S Radical SAM superfamily COG0641 Cluster_517863 V1226020 map00270,map01100,map04122 P sulfurtransferase COG2897 Cluster_614131 V1226022 S NA 11QRM Cluster_648866 V1226023 map05132 M repeat protein COG3209 Cluster_517864 V1226025 S Inherit from COG: oxidoreductase 0XPNK Cluster_517865 V1226026 SCLAV_3212 S NA 0XS1C Cluster_520402 V1226027 YKOD map02010 P ABC transporter COG1122 Cluster_528853 V1226029 S NA 0Z9V6 Cluster_517866 V1226031 V LlaJI restriction endonuclease 103AJ Cluster_724908 V1226032 S NA 0XWKC Cluster_520404 V1226034 LEPB map03060 U Signal peptidase i COG0681 Cluster_517867 V1226035 MURF map00300,map00550,map01100 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) COG0770 Cluster_517868 V1226036 S NA 12AUF Cluster_724909 V1226038 RLMB map00340,map00350,map00624,map01120 J RNA methyltransferase TrmH family group 3 COG0566 Cluster_517869 V1226039 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_517870 V1226040 S short chain dehydrogenase COG0300 Cluster_851782 V1226041 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_520405 V1226043 PARB K parb-like partition protein COG1475 Cluster_517872 V1226045 map02010 V ABC transporter COG1132 Cluster_917575 V1226048 RHTA S Membrane COG5006 Cluster_520407 V1226049 SCLAV_0509 S Cytochrome c oxidase caa3-type, assembly factor ctag-related protein COG3336 Cluster_711610 V1226051 FADD map00071,map01100,map03320,map04146,map04920 I AMP-binding enzyme COG1022 Cluster_640949 V1226052 P tonB-dependent Receptor 0XP5Y Cluster_517873 V1226056 PBP2B map00550,map01100 M penicillin-binding protein COG0768 Cluster_520408 V1226058 PSTS map02010,map02020,map05152 P Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) COG0226 Cluster_520409 V1226059 MRNC S Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) COG1939 Cluster_520410 V1226060 RBSA map02010 P ABC transporter COG1129 Cluster_520411 V1226061 YDCP map05120 O Peptidase, U32 family COG0826 Cluster_708473 V1226062 O Peptidase, M22 COG0533 Cluster_520412 V1226063 DDL map00473,map00520,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_517874 V1226064 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_585965 V1226070 FETB map02010 P Periplasmic binding protein COG4607 Cluster_520414 V1226076 S Membrane COG4129 Cluster_728181 V1226077 SCLAV_3101 S Inherit from NOG: Transcriptional regulator, arsR family 11YC6 Cluster_520415 V1226079 N repeat protein 11QCF Cluster_520416 V1226081 FTSI map00550,map01100 M Stage V sporulation protein D COG0768 Cluster_614132 V1226082 YCEG F aminodeoxychorismate lyase COG1559 Cluster_748118 V1226084 CZCD P cation diffusion facilitator family transporter COG0053 Cluster_520418 V1226086 RIBU S Membrane COG3601 Cluster_520419 V1226087 LPPS S ErfK ybiS ycfS ynhG family protein COG1376 Cluster_520420 V1226088 FEPD map02010 P transport system permease protein COG0609 Cluster_520421 V1226089 S NA 0Z0UZ Cluster_520422 V1226090 AHPF O Alkyl hydroperoxide reductase COG3634 Cluster_520423 V1226091 S OstA-like protein 11YB4 Cluster_520424 V1226092 HISC map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01230 E imidazole acetol-phosphate transaminase COG0079 Cluster_520426 V1226095 LYSC map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Aspartokinase COG0527 Cluster_523171 V1226096 HEME map00860,map01100,map01110 H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) COG0407 Cluster_523172 V1226097 M Glycosyl transferase, family 2 COG1216 Cluster_523173 V1226099 GLNA map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG0174 Cluster_520427 V1226101 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_520428 V1226103 P SNARE associated Golgi protein COG1238 Cluster_781120 V1226104 K Transcriptional regulator COG1396 Cluster_523176 V1226105 BMUL_2617 S NA 11QRE Cluster_520429 V1226106 U, W Inherit from COG: domain protein 121KM Cluster_648867 V1226109 I Acyl-transferase COG1835 Cluster_714985 V1226110 S NA 0ZD0C Cluster_523177 V1226112 ALST E amino acid carrier protein COG1115 Cluster_540142 V1226115 COBW S cobw p47k family protein COG0523 Cluster_523178 V1226117 NNRD G Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) COG0063 Cluster_520431 V1226121 P transport protein COG2985 Cluster_520432 V1226124 PEPP E peptidase, M24 COG0006 Cluster_596117 V1226126 GLSA map00250,map00330,map00471,map00910,map01100,map01120,map04724,map04727,map04964 E Glutaminase COG2066 Cluster_523180 V1226127 AHPF O Alkyl hydroperoxide reductase COG3634 Cluster_545963 V1226128 FBPA K Fibronectin-binding protein COG1293 Cluster_523181 V1226129 S Membrane 11K10 Cluster_531652 V1226132 GLYQS map00970 J Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) COG0423 Cluster_781121 V1226133 map00010,map00620,map00640,map00680,map00720,map01053,map01100,map01110,map01120 Q amino acid adenylation COG1020 Cluster_523183 V1226134 GLMU map00520,map01100,map01110 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) COG1207 Cluster_781122 V1226135 VIOA map00362,map00363,map00626,map00650,map00903,map01100,map01110,map01120 E DegT DnrJ EryC1 StrS COG0399 Cluster_589284 V1226136 O ADP-ribosylglycohydrolase COG2110 Cluster_520434 V1226137 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_523184 V1226139 S NA 11H99 Cluster_523185 V1226140 S NA 0YXIR Cluster_520435 V1226141 SBCC3 S Cytosolic protein COG4913 Cluster_523186 V1226142 DACA map00550,map01100 M d-alanyl-d-alanine carboxypeptidase COG1686 Cluster_523187 V1226143 V N-6 DNA Methylase COG0286 Cluster_526095 V1226145 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 Cluster_520436 V1226147 S (ABC) transporter 17563@proNOG Cluster_523188 V1226148 CCRB L Resolvase COG1961 Cluster_523189 V1226149 UVRA map03420 L excinuclease COG0178 Cluster_844093 V1226151 YBAB S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) COG0718 Cluster_773660 V1226152 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_781123 V1226153 CDD map00240,map00983,map01100,map05219 F cytidine deaminase COG0295 Cluster_855563 V1226157 OTSA map00500,map01100 G alpha-alpha-trehalose-phosphate synthase COG0380 Cluster_523190 V1226159 map02010 V ABC transporter, ATP-binding protein COG1132 Cluster_523191 V1226160 CTPC map00190 P heavy metal translocating P-type ATPase COG2217 Cluster_528854 V1226161 ESSC D ftsk spoIIIe COG1674 Cluster_523192 V1226162 CYCMA_0607 S transposase 11H93 Cluster_741459 V1226163 CMTB S esterase COG0627 Cluster_606812 V1226164 S Membrane 0Y2N2 Cluster_523194 V1226168 C FMN-binding domain protein COG3976 Cluster_523195 V1226169 PDXA map00750,map01100 H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) COG1995 Cluster_678620 V1226171 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_648869 V1226172 FADD map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG0318 Cluster_523196 V1226173 S esterase COG0627 Cluster_699209 V1226174 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_909045 V1226175 RECO map03440 L Involved in DNA repair and RecF pathway recombination (By similarity) COG1381 Cluster_844094 V1226176 TETR K Tetr family transcriptional regulator 11YGE Cluster_863902 V1226179 M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) COG4623 Cluster_687590 V1226181 YFMR S abc transporter COG0488 Cluster_913239 V1226182 MT1149 S Antibiotic biosynthesis monooxygenase COG1359 Cluster_644807 V1226184 SCLAV_2114 S Protein of unknown function (DUF3499) 11VV4 Cluster_523198 V1226187 S NA 101UU Cluster_738041 V1226188 S protein, conserved in bacteria COG1937 Cluster_714986 V1226191 S Inherit from COG: Involved in the degradation of specific anti-sigma factors (By similarity) COG2339 Cluster_640950 V1226193 S NA 11NX4 Cluster_523199 V1226194 WS0013 S membrAne 0XPGN Cluster_523200 V1226195 L Virulence-associated protein e COG5545 Cluster_938418 V1226196 S Hydrolase COG1011 Cluster_805123 V1226199 MODB map02010 P molybdate abc transporter COG4149 Cluster_731489 V1226200 GUFA P Mediates zinc uptake. May also transport other divalent cations (By similarity) COG0428 Cluster_526096 V1226201 S metal-dependent hydrolase COG1451 Cluster_644808 V1226212 S Membrane COG0392 Cluster_777381 V1226219 SSCG_03030 map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_526098 V1226222 PAP L polyphosphate kinase 2 COG2326 Cluster_526099 V1226223 ARGG map00250,map00330,map01100,map01110,map01230 E Citrulline--aspartate ligase COG0137 Cluster_640951 V1226228 map00790,map01100 H Pterin binding enzyme COG0294 Cluster_526100 V1226229 MRCA map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_585966 V1226230 L DNA primase catalytic core domain protein COG0358 Cluster_526101 V1226233 CAS3 L CRISPR-associated helicase, cas3 COG1203 Cluster_859568 V1226234 RBR C Rubrerythrin COG1592 Cluster_526102 V1226235 ABPB map00310,map00780,map01100 E Dipeptidase COG4690 Cluster_705381 V1226236 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_932125 V1226237 GLUQ map00860,map00970,map01100,map01110 J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) COG0008 Cluster_526103 V1226238 L dEAD DEAH box helicase COG1205 Cluster_867904 V1226240 RPSP map03010 J 30s ribosomal protein S16 COG0228 Cluster_526105 V1226241 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_526106 V1226243 S NA 11XKP Cluster_781125 V1226244 FECD map02010 P Permease protein COG0609 Cluster_625345 V1226247 S NA 0ZX1V Cluster_526107 V1226248 MT0808 S Inherit from COG: deacetylase COG3233 Cluster_526108 V1226250 S Primase C terminal 1 (PriCT-1) 0YFRN Cluster_528855 V1226251 S Rib/alpha-like repeat 10008 Cluster_526109 V1226253 map00340,map00350,map00624,map01120 Q methyltransferase COG0500 Cluster_592634 V1226255 map00300,map01100,map01110,map01120,map01230 E decarboxylase COG0019 Cluster_879982 V1226256 S ATP cone domain 0Y76S Cluster_526111 V1226260 RPOD K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_526112 V1226261 PKS13 Q PKS_AT COG3321 Cluster_526114 V1226263 SQDB map00520,map00561 M UDP-sulfoquinovose synthase 0XQJ1 Cluster_751537 V1226265 S NA 17GF8@proNOG Cluster_563719 V1226266 SCLAV_0908 K GntR family transcriptional regulator COG2186 Cluster_526115 V1226267 S Listeria-Bacteroides repeat domain (List_Bact_rpt) COG4886 Cluster_617889 V1226268 ACDA map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I acyl-CoA dehydrogenase COG2025 Cluster_528857 V1226271 AROA map00400,map01100,map01110,map01230 E 3-phosphoshikimate 1-carboxyvinyltransferase COG0128 Cluster_528858 V1226272 APEA map00480,map01100 E M18 family aminopeptidase COG1362 Cluster_644809 V1226273 GREA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) COG0782 Cluster_769980 V1226275 GALE map00052,map00520,map01100,map01110 M udp-glucose 4-epimerase COG1087 Cluster_528859 V1226277 LYTR1 K TRANSCRIPTIONal COG1316 Cluster_820739 V1226278 SALY V ABC transporter COG0577 Cluster_718237 V1226279 SARE_3729 L phage plasmid primase, p4 family COG3378 Cluster_528860 V1226280 INSI L transposase COG2826 Cluster_557703 V1226281 map02010 S permease yjgp yjgq COG0795 Cluster_528861 V1226282 ACRA6 V efflux transporter, rnd family, mfp subunit COG0845 Cluster_596118 V1226284 TRPD map00400,map01100,map01110,map01230 E anthranilate phosphoribosyltransferase COG0547 Cluster_699210 V1226285 RODA map00550,map04112 D cell cycle protein COG0772 Cluster_528862 V1226286 Z2133 S Phage portal protein lambda family COG5511 Cluster_773661 V1226287 ASD map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) COG0136 Cluster_809162 V1226288 LYSC map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Aspartokinase COG0527 Cluster_534435 V1226289 O peptidase COG1026 Cluster_610473 V1226291 MOAC map00790,map01100,map04122 H Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) COG0315 Cluster_528863 V1226292 FPRA map00250,map00910,map01100,map01110,map01120,map01230 C reductase COG0493 Cluster_599631 V1226294 BATA S von Willebrand factor, type A COG2304 Cluster_528864 V1226296 S NA 0YHNP Cluster_528865 V1226299 FAS map00061,map01100 I fatty acid synthase COG4982 Cluster_528866 V1226301 map00910 S 2-Nitropropane dioxygenase COG2070 Cluster_625346 V1226302 S Rhodanese-like domain 11QSF Cluster_687591 V1226303 U type ii secretion system 123KS Cluster_528868 V1226306 GAP map00010,map01100,map01110,map01120,map01230,map04066,map05010 G Glyceraldehyde-3-phosphate dehydrogenase COG0057 Cluster_599632 V1226310 G transporter 0XP7I Cluster_545964 V1226311 GSPE map03070 U type ii secretion system protein e COG2804 Cluster_636925 V1226312 map00680,map00860,map01100,map01110,map01120 H Methyltransferase MtaA CmuA family COG0407 Cluster_731491 V1226316 S NA 11U4D Cluster_528869 V1226317 THID map00730,map00750,map01100 H phosphomethylpyrimidine kinase COG0351 Cluster_657075 V1226319 PATB map00270,map00450,map00920,map01100,map01110,map01230 E Aminotransferase class I and II COG1168 Cluster_816925 V1226321 S NA 1031E Cluster_528870 V1226323 EMBC M Arabinosyltransferase 0XSQE Cluster_528871 V1226324 TRKH P Potassium uptake protein COG0168 Cluster_674184 V1226334 SCLAV_0509 S Cytochrome c oxidase caa3-type, assembly factor ctag-related protein COG3336 Cluster_531654 V1226336 M domain protein COG4932 Cluster_545965 V1226338 E Membrane dipeptidase (EC 3.4.13.19) COG2355 Cluster_621565 V1226339 V FtsX-like permease family COG0577 Cluster_836161 V1226340 SCLAV_3863 S Membrane 0XVS8 Cluster_871846 V1226341 GREA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) COG0782 Cluster_531655 V1226342 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_531656 V1226343 YJGR S ATP-binding protein COG0433 Cluster_863903 V1226345 RPMH map03010 J 50S ribosomal protein l34 COG0230 Cluster_531657 V1226347 MT3751 L Helicase COG1205 Cluster_531659 V1226350 VP1725 T cbs domain and cyclic nucleotide-regulated nucleotidyltransferase COG2905 Cluster_617890 V1226355 PROY E amino acid COG1113 Cluster_596119 V1226357 J RNA methyltransferase COG2265 Cluster_766250 V1226358 MRPF P monovalent cation H antiporter subunit F COG2212 Cluster_796990 V1226359 MRPG P CPA3 family monovalent cation (K or Na ) proton (H ) antiporter-3, MnhG subunit COG1320 Cluster_813150 V1226361 S UPF0473 protein 0Z6ED Cluster_738043 V1226362 RUVX L Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) COG0816 Cluster_531661 V1226366 METI map02010 P ABC transporter, permease COG2011 Cluster_531662 V1226367 NAGB map00520,map01100,map01110 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COG0363 Cluster_531663 V1226369 M domain protein COG4932 Cluster_531664 V1226370 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_531665 V1226371 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_614133 V1226373 L site-specific recombinase, phage integrase family 0ZJK4 Cluster_531667 V1226374 L Transposase 16YCN@proNOG Cluster_728182 V1226377 ADCC map02010 P ABC transporter COG1121 Cluster_721562 V1226378 CMRA S Dehydrogenase COG0300 Cluster_531669 V1226379 S NA 11FWK Cluster_531672 V1226382 RV0495C S NA 0ZV27 Cluster_781126 V1226383 S Sodium:solute symporter family COG4147 Cluster_621566 V1226384 NPSC Q amino acid adenylation domain protein COG1020 Cluster_531673 V1226385 UVRD2 map03420,map03430 L helicase COG2887 Cluster_531674 V1226386 ARGD map00300,map00330,map01100,map01110,map01120,map01210,map01230 E acetylornithine aminotransferase COG4992 Cluster_534436 V1226387 SGLY_0535 S phage protein 0XNW6 Cluster_531675 V1226389 CARA map00240,map00250,map01100 F carbamoyl-phosphate synthetase glutamine chain COG0505 Cluster_695930 V1226390 YADS S Membrane COG2860 Cluster_531676 V1226392 DGT map00230 F deoxyguanosinetriphosphate triphosphohydrolase-like protein COG0232 Cluster_531678 V1226394 S alpha beta COG1073 Cluster_531679 V1226395 OPCA G OpcA protein COG3429 Cluster_531681 V1226397 map01053 Q non-ribosomal peptide synthetase COG1020 Cluster_531682 V1226399 ESSC D ftsk spoIIIe COG1674 Cluster_534437 V1226400 PUTA map00250,map00330,map01100,map01110 C Dehydrogenase COG1012 Cluster_644810 V1226401 K transcriptional regulator), MarR family 129SD Cluster_534438 V1226402 GCVP map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG1003 Cluster_531683 V1226403 HLYX P CBS domain protein COG1253 Cluster_531685 V1226407 LYTB map00511 G endo-beta-N-acetylglucosaminidase COG4193 Cluster_563720 V1226408 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_796991 V1226409 RPMF map03010 J 50S ribosomal protein L32 COG0333 Cluster_640952 V1226411 TRPC map00400,map01100,map01110,map01230 E Indole-3-glycerol phosphate synthase COG0135 Cluster_531686 V1226412 DPNII V Type II restriction 0YTH4 Cluster_692117 V1226413 SORA C Superoxide reductase COG2033 Cluster_534440 V1226415 FTSP D Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) COG2132 Cluster_632889 V1226417 TRPG map00230,map00400,map00790,map00983,map01100,map01110,map01230 E anthranilate synthase COG0512 Cluster_534441 V1226419 CORA P transporter COG0598 Cluster_534443 V1226422 S PspC domain-containing protein 0Y3A6 Cluster_531687 V1226425 S CHAP domain 0ZJI2 Cluster_599633 V1226428 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_617891 V1226429 map00680,map00982,map01120 P oxidoreductase COG2072 Cluster_531689 V1226430 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_534444 V1226431 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_534445 V1226432 AFTA M Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases 0Z57H Cluster_531690 V1226433 OLIA S Oligopeptide transporter, Opt family COG1297 Cluster_534446 V1226434 HRRS T Histidine kinase 0XNMH Cluster_738044 V1226435 METI map02010 P ABC transporter, permease COG2011 Cluster_840037 V1226436 L site-specific recombinase, phage integrase family 0ZF8H Cluster_531691 V1226437 P Pfam:C4dic_mal_tran COG1275 Cluster_879985 V1226438 YGEY map00330,map01100,map01110,map01210,map01230 E M20 DapE family protein YgeY COG0624 Cluster_751538 V1226439 YGEW E Carbamoyltransferase COG0078 Cluster_531692 V1226441 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_816928 V1226443 S NA 0ZMA4 Cluster_534448 V1226445 MMPL3 H MMPL domain protein COG2409 Cluster_534449 V1226446 S Transporter Permease Protein 0ZURF Cluster_534451 V1226449 map03440 K Transcriptional regulator COG2865 Cluster_748122 V1226450 MRA_3235 O glutaredoxin-like protein COG0695 Cluster_534452 V1226452 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_534453 V1226453 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_534456 V1226456 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_534457 V1226458 DNAQ map03420,map03430 L Uvrd rep helicase COG2176 Cluster_718240 V1226460 S Toxin-antitoxin system, toxin component, Fic family COG3943 Cluster_534459 V1226463 GTO2 O Glutathione S-transferase COG0435 Cluster_534460 V1226464 L NA 0Y131 Cluster_534461 V1226465 I Acyltransferase family COG1835 Cluster_537332 V1226468 RV1842C P integral membrane protein COG1253 Cluster_534462 V1226470 S Inherit from COG: Membrane COG3601 Cluster_537333 V1226471 S NA 12BGZ Cluster_534463 V1226473 GLNA map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG0174 Cluster_534464 V1226474 RECG map03420,map03440 L ATP-dependent DNA helicase recg COG1200 Cluster_534465 V1226475 FHAA T FHA Domain-Containing protein COG1716 Cluster_534466 V1226476 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_537334 V1226477 S Periplasmic Protein COG1434 Cluster_625347 V1226478 V ABC transporter, ATP-binding protein COG1132 Cluster_669785 V1226479 COPZ map04978 P Heavy metal-associated domain protein 0XUQ1 Cluster_534467 V1226480 S NA 0ZWJK Cluster_534469 V1226483 S NA 11NI8 Cluster_534470 V1226484 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_875950 V1226485 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_705382 V1226486 S NA 0XQ6D Cluster_537335 V1226487 S DNA-binding protein COG3943 Cluster_537336 V1226489 V HNHc 125G9 Cluster_603203 V1226491 S conjugation system ATPase, TraG family 0XSHU Cluster_534471 V1226492 S Terminase 0XRHX Cluster_537338 V1226493 SUCB map00010,map00020,map00280,map00310,map00620,map01100,map01110,map01120 C 2-oxoglutarate dehydrogenase E2 component, dihydrolipoamide succinyltransferase COG0508 Cluster_844097 V1226494 map03440 K Transcriptional regulator COG2865 Cluster_762284 V1226495 map03440 K Transcriptional regulator COG2865 Cluster_537339 V1226496 NMB0459 S Filamentation induced by cAMP protein fic COG3177 Cluster_537340 V1226497 M efflux transporter, rnd family, mfp subunit COG0845 Cluster_534472 V1226498 TIPA K Transcriptional regulator COG0789 Cluster_537341 V1226500 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_537343 V1226506 S Rib/alpha-like repeat 0YK85 Cluster_669786 V1226509 RPLU map03010 J This protein binds to 23S rRNA in the presence of protein L20 (By similarity) COG0261 Cluster_534473 V1226510 M Inherit from NOG: domain protein 18B9F@proNOG Cluster_718241 V1226511 map00052,map00520,map01100,map01110 G, M epimerase COG0451 Cluster_537344 V1226513 UPP map00240,map01100 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) COG0035 Cluster_537345 V1226514 P ATPase, P-type (Transporting), HAD superfamily, subfamily IC COG0474 Cluster_537346 V1226515 PKS13 Q PKS_AT COG3321 Cluster_537347 V1226516 MT2318 V Beta-lactamase COG1680 Cluster_543023 V1226517 S Secreted protein COG1376 Cluster_537348 V1226518 SUN J Fmu (Sun) domain-containing protein COG0144 Cluster_621567 V1226519 LTAE map00260,map01100,map01110,map01120,map01230 E Aldolase COG2008 Cluster_537349 V1226520 SPOU J rrna methyltransferase COG0566 Cluster_836162 V1226521 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_921492 V1226522 RPMG map03010 J 50S ribosomal protein L33 COG0267 Cluster_537350 V1226523 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_648870 V1226524 OPPC P Binding-protein-dependent transport systems inner membrane component COG1173 Cluster_563721 V1226525 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_614134 V1226528 YQEK map00760,map01100 H Metal Dependent Phosphohydrolase COG1713 Cluster_665473 V1226529 RSBV T stage II sporulation protein COG1366 Cluster_537351 V1226530 AMAA map00360 E amidohydrolase COG1473 Cluster_617892 V1226531 PSTC map02010 P phosphate abc transporter COG0573 Cluster_699211 V1226532 FHAB T Fha domain containing protein COG1716 Cluster_793040 V1226533 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_603204 V1226534 MPRB map02020 T Histidine kinase COG0642 Cluster_754998 V1226537 NOSZ map00910,map01120 C Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide (By similarity) COG4263 Cluster_537352 V1226539 MANB map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G phosphomannomutase COG1109 Cluster_537353 V1226540 ALAP E amino acid carrier protein COG1115 Cluster_537356 V1226546 S Bacterial protein of unknown function (DUF885) COG4805 Cluster_540143 V1226547 FBP map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120 G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 COG3855 Cluster_566917 V1226550 PHOR map02020 T Histidine kinase 0XNMH Cluster_540145 V1226551 PATB map00270,map00450,map00920,map01100,map01110,map01230 E Aminotransferase class I and II COG1168 Cluster_543024 V1226552 S NA 0ZA92 Cluster_537357 V1226553 SDRA V type iii restriction COG1061 Cluster_596120 V1226554 L Phage terminase, large subunit COG1783 Cluster_540146 V1226555 MANA map00051,map00520,map01100,map01110 G mannose-6-phosphate isomerase COG1482 Cluster_632890 V1226559 S hmm pf04634 0Y5PY Cluster_537358 V1226561 GLNE O, T Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) COG1391 Cluster_537359 V1226564 PUTA map00250,map00330,map01100,map01110 C Dehydrogenase COG1012 Cluster_537360 V1226569 YCHF J gtp-binding protein COG0012 Cluster_540148 V1226571 S NA 0Y6Z1 Cluster_540150 V1226574 K transcriptional regulator DeoR family COG1349 Cluster_695931 V1226575 OXYR K Transcriptional regulator 0XNR2 Cluster_661301 V1226577 CAS1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) COG1518 Cluster_560762 V1226578 HEMN map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_537362 V1226579 RLMB map00340,map00350,map00624,map01120 J RNA methyltransferase TrmH family group 3 COG0566 Cluster_540151 V1226580 L adenine specific DNA methyltransferase COG4889 Cluster_537363 V1226581 S Domain of unknown function (DUF222) 11KRE Cluster_540152 V1226582 CP_0141 S metallophosphoesterase COG1768 Cluster_537364 V1226585 METE map00270,map00450,map01100,map01110,map01230 E Methionine synthase COG0620 Cluster_652947 V1226586 BIOB map00780,map01100 H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) COG0502 Cluster_744772 V1226587 ATPG map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) COG0224 Cluster_751539 V1226593 PSAA map02010 P ABC transporter COG0803 Cluster_543025 V1226595 BL01965 S trap transporter, 4tm 12tm fusion protein COG4666 Cluster_614135 V1226596 NHAC C Na H antiporter COG1757 Cluster_540156 V1226599 map00550,map01100 M glycosyl transferase, family 51 COG0744 Cluster_540157 V1226603 FBP map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120 G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 COG3855 Cluster_648871 V1226604 J Elongation factor Tu GTP binding domain COG0050 Cluster_540158 V1226605 GLTS E Sodium Glutamate Symporter COG0786 Cluster_848009 V1226606 PHNA map00440,map01120 P Alkylphosphonate utilization operon protein PhnA COG2824 Cluster_699212 V1226607 HISD map00340,map01100,map01110,map01230 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) COG0141 Cluster_669787 V1226609 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_648872 V1226611 RPLQ map03010 J 50S ribosomal protein l17 COG0203 Cluster_582781 V1226613 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_540160 V1226614 YBBP S TIGR00159 family COG1624 Cluster_751540 V1226615 YBBB S integral membrane protein COG3548 Cluster_543026 V1226617 HEMA map00860,map01100,map01110 H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) COG0373 Cluster_543027 V1226618 M domain protein COG4932 Cluster_540161 V1226622 F ATP cone domain COG1328 Cluster_543029 V1226624 S NA 10XZZ Cluster_751541 V1226625 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_844098 V1226626 GLMU map00520,map01100,map01110 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) COG1207 Cluster_711613 V1226628 PIMB M Glycosyl transferase (Group 1 COG0438 Cluster_888071 V1226629 CG2401 M Secreted protein COG0791 Cluster_702290 V1226630 FETB map02010 P Periplasmic binding protein COG4607 Cluster_617893 V1226632 YKOD map02010 P ABC transporter COG1122 Cluster_734704 V1226634 J Inherit from COG: tryptophanyltRNA synthetase COG0180 Cluster_543031 V1226637 M peptidase M23 COG0739 Cluster_543032 V1226641 HYDE map00780,map01100 H radical SAM domain protein COG0502 Cluster_540165 V1226644 DPPD map02010 E, P (ABC) transporter COG0444 Cluster_636928 V1226646 LEBU_0481 L Transposase COG1943 Cluster_543035 V1226651 PURF map00230,map00250,map01100,map01110 F glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_589285 V1226652 FTSQ map04112 M domain protein, FtsQ-type COG1589 Cluster_543036 V1226654 LGT M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 Cluster_543037 V1226655 HYDA map00240,map00410,map00770,map00983,map01100 F dihydropyrimidinase (EC 3.5.2.2) COG0044 Cluster_543038 V1226656 G Major Facilitator superfamily 11Q79 Cluster_543039 V1226658 HRCA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) COG1420 Cluster_543040 V1226662 S NA 0Z9V6 Cluster_543041 V1226665 E Family 5 COG0747 Cluster_678623 V1226667 YEDF O Redox protein COG0425 Cluster_867907 V1226668 URAA F permease COG2233 Cluster_836164 V1226669 RPSN map03010 J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) COG0199 Cluster_769982 V1226670 RPSR map03010 J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) COG0238 Cluster_543043 V1226671 E Peptidase dimerisation domain COG1473 Cluster_543045 V1226674 FADD map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG0318 Cluster_599634 V1226677 CTAD map00190,map00910,map01100 C Cytochrome C oxidase, subunit I COG0843 Cluster_543047 V1226678 S NA 0XSI9 Cluster_543048 V1226679 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_543049 V1226680 S Rib/alpha-like repeat 10008 Cluster_606814 V1226682 BFRB map00860 P ferritin COG1528 Cluster_751542 V1226683 GLF M udp-galactopyranose mutase COG0562 Cluster_543050 V1226686 THRS map00020,map00300,map00630,map00720,map01100,map01110,map01120,map01210,map01230 C Aconitate hydratase COG1048 Cluster_549015 V1226687 S NA 0XP7E Cluster_545966 V1226691 GLMU map00520,map01100,map01110 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) COG1207 Cluster_585967 V1226694 RAMA K LuxR family transcriptional regulator COG2771 Cluster_543053 V1226697 TIG O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COG0544 Cluster_884163 V1226699 CG1669 S secreted protein COG2353 Cluster_629066 V1226701 K Transcriptional Regulator, LuxR family 0Y1WM Cluster_657076 V1226702 S NA 17265@proNOG Cluster_545968 V1226704 O Pfam:DUF395 COG2391 Cluster_554790 V1226706 IOLTB G ABC transporter COG1172 Cluster_543054 V1226707 S radical SAM domain protein COG0535 Cluster_741464 V1226708 S NA 0YRPX Cluster_545969 V1226709 YDFG map00051,map00240,map00363,map00430,map00591,map00625,map00650,map01100,map01120 S Oxidoreductase, short chain dehydrogenase reductase family COG4221 Cluster_543055 V1226710 AHPF O Alkyl hydroperoxide reductase COG3634 Cluster_724911 V1226711 GALT map00052,map00520,map01100,map01110 G galactose-1-phosphate uridylyltransferase COG1085 Cluster_545970 V1226712 C Oxidoreductase, Aldo keto reductase family COG0667 Cluster_644811 V1226714 PSAA map02010 P ABC transporter COG0803 Cluster_781127 V1226715 L Integrase 0YTFQ Cluster_800929 V1226716 S NA 0YI3H Cluster_545971 V1226717 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_545972 V1226719 S Uncharacterized protein conserved in bacteria (DUF2179) COG1284 Cluster_543056 V1226720 ISPH map00900,map01100,map01110,map03010 I Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) COG0761 Cluster_545973 V1226721 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_777383 V1226722 S NA 12C56 Cluster_921495 V1226724 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_762285 V1226726 MT3357 S Possibl zinc metallo-peptidase 11VPR Cluster_545974 V1226728 S NA 0YUW4 Cluster_596121 V1226731 CDR P pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_545976 V1226732 M Cell wall anchor domain protein 129AF Cluster_840040 V1226734 PDXY map00750,map01100 H functions in a salvage pathway. Uses pyridoxamine (By similarity) COG2240 Cluster_545978 V1226737 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_545979 V1226739 RADC2 L DNA repair protein (RadC COG2003 Cluster_545980 V1226740 RBSC map02010,map02030 G abc transporter COG1172 Cluster_545981 V1226741 SITC map02010,map02020 P ABC transporter COG1108 Cluster_545983 V1226743 HRPA L ATP-dependent helicase COG1643 Cluster_805126 V1226744 NAMU_1182 L Transposase COG3328 Cluster_545984 V1226745 S acyltransferase 3 124R2 Cluster_545985 V1226747 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_738045 V1226748 MALX map00010,map00500,map00520,map02060 G PTS System COG2190 Cluster_625348 V1226749 ISPE map00900,map01100,map01110 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COG1947 Cluster_606815 V1226750 T regulatoR COG2197 Cluster_545986 V1226751 V Type III COG3587 Cluster_632892 V1226754 S Fic/DOC family 0ZXM7 Cluster_549017 V1226755 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_545987 V1226756 S NA 0YHMP Cluster_614138 V1226757 P ABC transporter, permease COG0601 Cluster_636929 V1226758 MGTA map00051 M Glycosyl transferase (Group 1 COG0438 Cluster_545988 V1226760 V ABC transporter, ATP-binding protein COG1132 Cluster_549018 V1226762 SCLAV_1126 map02010 V (ABC) transporter COG0842 Cluster_657077 V1226763 J Protein of unknown function (DUF464) COG2868 Cluster_793043 V1226764 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_738046 V1226765 PPA map00190 C pyrophosphate phospho-hydrolase COG0221 Cluster_545990 V1226766 M domain protein 0ZWTG Cluster_741465 V1226767 NUDF map00230 F nudix hydrolase COG0494 Cluster_545991 V1226768 GLUC map02010 E ABC transporter COG0765 Cluster_545992 V1226769 NDVA2 V ABC transporter, ATP-binding protein COG1132 Cluster_549019 V1226770 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_545993 V1226771 PYRC map00240,map01100 F dihydroorotase COG0044 Cluster_777385 V1226772 S NA 125T8 Cluster_545994 V1226774 P transporter COG0471 Cluster_545995 V1226775 M domain protein COG4932 Cluster_545996 V1226777 LDH map00010,map00270,map00620,map00640,map01100,map01110,map01120 C L-lactate dehydrogenase COG0039 Cluster_855568 V1226781 SCLAV_2829 S Sec-C motif domain protein 100MK Cluster_549022 V1226784 WECC map00051,map00363,map00520,map00591,map00625,map00650,map01100,map01120 M Dehydrogenase COG0677 Cluster_793045 V1226785 S NA 0Z261 Cluster_545998 V1226786 SSDA map00250,map00350,map00650,map01100,map01120 C Dehydrogenase COG1012 Cluster_652948 V1226787 CYNT map00910 P carbonic anhydrase COG0288 Cluster_549023 V1226788 METB map00260,map00270,map00450,map00920,map01100,map01110,map01230 E cystathionine COG0626 Cluster_549025 V1226790 PHOR T Histidine kinase 0XNMH Cluster_549026 V1226791 MT3543 S NA 11ISP Cluster_549027 V1226793 DAGA E amino acid carrier protein COG1115 Cluster_796994 V1226794 NOCA_0571 L transposase COG2963 Cluster_805127 V1226795 L DNA binding domain protein, excisionase family 121NU Cluster_773664 V1226796 map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_554791 V1226797 NAMU_1215 L Integrase COG0582 Cluster_549028 V1226798 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) COG0167 Cluster_546000 V1226801 S NA 0YBQM Cluster_549029 V1226802 S membrane COG1511 Cluster_702291 V1226803 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_546001 V1226804 L Helicase COG4581 Cluster_748124 V1226806 map00500,map01100,map04973 G alpha amylase, catalytic COG0366 Cluster_560763 V1226812 GLPF G glycerol uptake facilitator protein COG0580 Cluster_549031 V1226813 YOCR P Transporter COG0733 Cluster_711615 V1226814 NAGB map00520,map01100,map01110 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COG0363 Cluster_687592 V1226815 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_640954 V1226818 E DegT/DnrJ/EryC1/StrS aminotransferase family COG0520 Cluster_549034 V1226820 COBJ map00860,map01100 H Precorrin-3B C17-methyltransferase COG1010 Cluster_549035 V1226821 MQO map00620 C malate dehydrogenase (quinone) COG0579 Cluster_549036 V1226822 BL02952 S Membrane COG1434 Cluster_636930 V1226824 NRDR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) COG1327 Cluster_617894 V1226826 S NA 0YF67 Cluster_551920 V1226827 CMEB V Multi-drug resistance protein COG0841 Cluster_549037 V1226828 O AhpC Tsa family 0ZVMV Cluster_549039 V1226830 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_751543 V1226832 SECG map03060,map03070 U Preprotein translocase SecG subunit COG1314 Cluster_828551 V1226836 S HipA domain protein COG3550 Cluster_599635 V1226837 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_551922 V1226839 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_549040 V1226840 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_549041 V1226842 S NA 0ZMT1 Cluster_551923 V1226844 map00300,map01100,map01210,map01230 H, J Alpha-L-glutamate ligase, RimK family COG0189 Cluster_549043 V1226845 S NA 0ZTYV Cluster_549045 V1226853 S Bacterial protein of unknown function (DUF885) COG4805 Cluster_551924 V1226856 ARCC map00230,map00330,map00910,map01120 E carbamate kinase COG0549 Cluster_549047 V1226861 YGEW E Carbamoyltransferase COG0078 Cluster_549048 V1226862 GND map00030,map00480,map01100,map01110,map01120 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) COG0362 Cluster_551925 V1226863 HALSA_0542 L Integrase core domain protein COG2801 Cluster_549049 V1226864 YBAK S YbaK ebsC protein COG2606 Cluster_699215 V1226866 V ABC transporter COG1131 Cluster_551926 V1226868 S Esterase COG0627 Cluster_551927 V1226869 S Phage head morphogenesis protein 0ZW5P Cluster_549050 V1226870 POLA_2 L DNA polymerase 0XRUF Cluster_551928 V1226871 CLPE O ATP-dependent clp protease, ATP-binding subunit COG0542 Cluster_896314 V1226872 NUOD map00190,map00910,map01100 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) COG0852 Cluster_551930 V1226879 IDSA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_551931 V1226880 S conjugation system ATPase, TraG family 0XSHU Cluster_625349 V1226881 HSPR K merR family transcriptional Regulator COG0789 Cluster_563722 V1226883 MT4028 S NA 0XRB8 Cluster_678624 V1226885 VIUB P Iron utilization protein 0XZPG Cluster_648875 V1226886 MNHE P monovalent cation H antiporter subunit E COG1863 Cluster_683159 V1226888 APL map00627,map00790,map01100,map01120,map02020 S SNARE associated Golgi COG0586 Cluster_610476 V1226889 K RNA Polymerase 11UY6 Cluster_557704 V1226890 NORM V Mate efflux family protein COG0534 Cluster_718242 V1226891 M hydrolase, family 25 COG3757 Cluster_551932 V1226893 GCVP map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG1003 Cluster_777386 V1226895 RPME map03010 J 50s ribosomal protein l31 COG0254 Cluster_617896 V1226897 CCPB K laci family transcriptional regulator 11HUZ Cluster_599636 V1226901 P ABC transporter substrate-binding protein 0XTCH Cluster_648876 V1226902 PHOB map02020 T Two component transcriptional regulator, winged helix family COG0745 Cluster_614139 V1226903 CBIO map02010 P abc transporter COG1122 Cluster_551933 V1226905 map00260,map01100 E FAD dependent oxidoreductase 11P73 Cluster_554792 V1226906 P p-type ATPase COG2217 Cluster_554793 V1226907 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_551934 V1226908 L RecT family 11V51 Cluster_785252 V1226910 SIGD K RNA Polymerase 10PD0 Cluster_554794 V1226912 PSTA map02010 P phosphate ABC transporter, permease COG0581 Cluster_554795 V1226913 YRBC K transcriptional regulatory protein COG0217 Cluster_560764 V1226916 M efflux transporter, rnd family, mfp subunit COG0845 Cluster_551936 V1226919 WBBL M Glycosyl transferase, family 2 COG1216 Cluster_551937 V1226920 S NA 11HU2 Cluster_589286 V1226921 S NA 11H5V Cluster_554797 V1226925 MDH map00620,map00710,map01100,map01120,map02020 C malate dehydrogenase (Oxaloacetate-decarboxylating) COG0281 Cluster_554798 V1226926 SCLAV_4880 map00500,map01100,map01110 G Glycogen debranching enzyme COG1523 Cluster_551938 V1226927 S Rib/alpha-like repeat 10008 Cluster_820740 V1226930 V Abi-like protein COG4823 Cluster_554799 V1226931 RV0561C map00860,map00900,map01100,map01110 C geranylgeranyl reductase COG0644 Cluster_569996 V1226933 S Protein of unknown function (DUF721) 122P4 Cluster_554800 V1226934 PUTP E Sodium proline symporter COG0591 Cluster_851787 V1226937 S Pfam:DUF88 COG1432 Cluster_566919 V1226938 SURB S G5 domain protein 0ZVV3 Cluster_661302 V1226939 S NA 1241G Cluster_554802 V1226943 PIP map00330 L Prolyl aminopeptidase COG0596 Cluster_554803 V1226944 PDXS map00750 H Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) COG0214 Cluster_554804 V1226947 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_554805 V1226948 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_554807 V1226953 L helicase COG4581 Cluster_554808 V1226954 YQHH L helicase domain protein COG0553 Cluster_554810 V1226957 ISPG map00900,map01100,map01110 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) COG0821 Cluster_773666 V1226958 YJIM E 2-hydroxyglutaryl-CoA dehydratase COG1775 Cluster_621569 V1226960 M Polysaccharide Biosynthesis Protein COG2244 Cluster_554811 V1226961 YIEG S Xanthine uracil vitamin C permease COG2252 Cluster_554812 V1226962 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_665475 V1226964 M Alpha beta hydrolase fold COG1073 Cluster_554813 V1226965 DPPD E, P (ABC) transporter COG0444 Cluster_554814 V1226966 HFLC O SPFH domain, Band 7 family protein COG0330 Cluster_744773 V1226967 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_744774 V1226973 NNR G carbohydrate kinase, YjeF related protein COG0063 Cluster_557706 V1226976 RSFS S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) COG0799 Cluster_554818 V1226979 S NA 0ZR4W Cluster_554819 V1226980 YBIT S ABC transporter COG0488 Cluster_793046 V1226981 O Heat shock protein COG0443 Cluster_554820 V1226984 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_554821 V1226985 CRTI map00906,map01100,map01110 Q phytoene COG1233 Cluster_557707 V1226986 PPSA S pyruvate phosphate dikinase 0XRDW Cluster_554822 V1226988 MTRB map02020 T Histidine kinase 0XNMH Cluster_582783 V1226989 HGAIR V Type II restriction enzyme HgAI 17Y1D@proNOG Cluster_554823 V1226990 S integral membrane alanine and leucine rich protein 11NPN Cluster_554824 V1226991 BMUL_5818 C Iron-sulfur cluster binding protein COG1139 Cluster_731493 V1226992 PYRC map00240,map01100 F dihydroorotase COG0044 Cluster_554825 V1226994 CITM C Citrate transporter COG2851 Cluster_557709 V1226995 S NA 0XSAP Cluster_554826 V1226997 map00770,map01100 S NA 0Y4HT Cluster_554827 V1226998 SCLAV_3485 E amino acid COG0531 Cluster_554828 V1226999 BMUL_5652 L Transposase COG2801 Cluster_554829 V1227000 S phage portal protein HK97 family COG4695 Cluster_773668 V1227003 COPZ map04978 P heavy metal transport detoxification protein 0XUQ1 Cluster_632893 V1227004 S Protein of unknown function (Porph_ging) 124PH Cluster_557710 V1227005 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_554830 V1227007 C nitrilase cyanide hydratase and apolipoprotein n-acyltransferase COG0388 Cluster_592636 V1227009 YKOD map02010 P ABC transporter COG1122 Cluster_557711 V1227010 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_665476 V1227011 FPRA map00250,map00910,map01100,map01110,map01120,map01230 C reductase COG0493 Cluster_711616 V1227012 S tm2 domain 127T8 Cluster_557712 V1227014 SIGM K RNA polymerase COG1595 Cluster_805128 V1227015 S Gnat family 0ZMKQ Cluster_557713 V1227016 FADD3 map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG1022 Cluster_621570 V1227018 map02020 K Transcriptional regulator (AraC family) COG4753 Cluster_557714 V1227019 SCLAV_2537 J methyltransferase COG2890 Cluster_557715 V1227023 PAC S PAC2 family 0XNTG Cluster_557718 V1227029 FABG map00061,map00780,map01040,map01100 S reductase 0XNW1 Cluster_557719 V1227030 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_557720 V1227031 MANA map00051,map00520,map01100,map01110 G mannose-6-phosphate isomerase COG1482 Cluster_557721 V1227032 S Membrane 11NXG Cluster_793047 V1227034 S conserved domain protein 11G4D Cluster_557723 V1227035 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_557724 V1227036 MODA map02010 P ABC transporter, periplasmic molybdate-binding protein COG0725 Cluster_896315 V1227037 PURS map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG1828 Cluster_762287 V1227039 map02010 P cobalt transport COG1122 Cluster_621571 V1227042 S Pfam:DUF151 COG1259 Cluster_625350 V1227043 YUTD S transcriptional regulator COG4470 Cluster_632894 V1227044 SP_1232 S Membrane COG4684 Cluster_557727 V1227046 PSTC map02010 P phosphate abc transporter COG0573 Cluster_557728 V1227047 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_557729 V1227048 GBS0402 U Inherit from COG: type IV secretion system protein COG3451 Cluster_751545 V1227050 AHPC O C-terminal domain of 1-Cys peroxiredoxin COG0450 Cluster_721566 V1227051 P binding-protein-dependent transport systems inner membrane Component COG4132 Cluster_560765 V1227055 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_557731 V1227056 NLPD M peptidase COG0739 Cluster_560766 V1227058 S Putative esterase COG0627 Cluster_560767 V1227059 KDPA map02020 P One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) COG2060 Cluster_614140 V1227060 S NA 16WMR@proNOG Cluster_557732 V1227061 GUAD map00230,map01100 F, J deaminase COG0590 Cluster_557733 V1227062 M Cell surface protein 11GRZ Cluster_629068 V1227063 AER map02020,map02030 T methyl-accepting chemotaxis protein COG2202 Cluster_557735 V1227068 LACZ map00052,map00511,map00600,map01100 G Glycoside hydrolase family 2 TIM barrel COG3250 Cluster_781128 V1227070 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_820741 V1227071 ECFT map02010 P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) COG0619 Cluster_909049 V1227072 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_738048 V1227073 S carboxymuconolactone decarboxylase COG2128 Cluster_661303 V1227075 S DNA-binding protein COG3943 Cluster_758524 V1227077 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins COG0706 Cluster_560769 V1227078 DNAE2 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase (By similarity) COG0587 Cluster_560770 V1227079 UPPP map00550 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) COG1968 Cluster_560771 V1227083 DCTP C symporter COG1301 Cluster_563723 V1227085 CPS4C M biosynthesis protein COG3944 Cluster_665478 V1227086 NOSL S (LipO)protein 11SY9 Cluster_557736 V1227087 S NA 11JP6 Cluster_557737 V1227089 M Cell wall binding repeat 2-containing protein COG2247 Cluster_560772 V1227090 FECB map02010 P Transporter COG4594 Cluster_560773 V1227091 HYPB K, O Hydrogenase accessory protein HypB COG0378 Cluster_560775 V1227094 map00561,map01100 S Secretory lipase 0YTM1 Cluster_805129 V1227095 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_560776 V1227096 TAL map00010,map00030,map00500,map00520,map00710,map01051,map01100,map01110,map01120,map01230 G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) COG0176 Cluster_606817 V1227098 ACNA map00020,map00300,map00630,map00720,map01100,map01110,map01120,map01210,map01230 C aconitate hydratase COG1048 Cluster_755001 V1227100 GSP map00480,map01100 E Glutathionylspermidine synthase COG0754 Cluster_560778 V1227101 S peptidase, S41 11FNN Cluster_652950 V1227102 NHAC map00680 C Na H antiporter COG1757 Cluster_560779 V1227103 V type I restriction-modification system COG0286 Cluster_560780 V1227106 P arsenical pump membrane protein 0Y1CV Cluster_652951 V1227107 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_560781 V1227108 PITRM1 O peptidase COG1026 Cluster_560782 V1227109 M Inherit from NOG: glycosyl transferase group 1 0XT85 Cluster_800932 V1227110 S PRC-barrel domain-containing protein 11GJ7 Cluster_560783 V1227111 S NA 12B8X Cluster_674186 V1227112 M Inherit from COG: choline binding protein COG4990 Cluster_579544 V1227113 LACR K DeoR family transcriptional regulator COG1349 Cluster_560784 V1227114 PEPQ map00310,map00780,map01100 E peptidase M24 COG0006 Cluster_560785 V1227115 RV2876 S Protein of unknown function (DUF2631) 0Y36A Cluster_560786 V1227116 S tail tape measure protein COG5283 Cluster_560787 V1227117 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_644812 V1227118 S NA 0ZH06 Cluster_648877 V1227119 LDH map00010,map00270,map00620,map00640,map01100,map01110,map01120 C Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) COG0039 Cluster_785255 V1227120 YRHP E lysine exporter protein LysE YggA COG1280 Cluster_695933 V1227122 NAMU_1182 L Transposase COG3328 Cluster_560788 V1227126 S filamentation induced by cAMP protein fic COG3177 Cluster_560789 V1227129 PSTS2 map02010,map02020,map05152 P Phosphate-binding protein COG0226 Cluster_560790 V1227132 SDAC E Serine transporter COG0814 Cluster_560791 V1227133 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_773670 V1227134 SCLAV_0739 map00620 S Beta-lactamase domain protein 10GCR Cluster_836167 V1227135 TPX O Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) COG2077 Cluster_563724 V1227136 S Rib/alpha-like repeat 10008 Cluster_560792 V1227137 P peroxidase COG2837 Cluster_560793 V1227138 S Glyoxalase Bleomycin resistance protein (Dioxygenase COG3324 Cluster_563727 V1227142 PGSA1 map00562,map00564,map01100,map04070 I Cdp-alcohol phosphatidyltransferase COG0558 Cluster_592637 V1227143 S (ABC) transporter 11JQQ Cluster_828552 V1227144 DCMB map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_563728 V1227147 S auxin efflux carrier COG0679 Cluster_560794 V1227149 EUTP E ethanolamine transporter COG0531 Cluster_793049 V1227152 NAGB map00520,map01100,map01110 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COG0363 Cluster_563730 V1227153 SCLAV_4880 map00500,map01100,map01110 G Glycogen debranching enzyme COG1523 Cluster_563731 V1227156 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_563732 V1227158 MMPL H MMPL domain protein COG2409 Cluster_560796 V1227162 LMRB P drug resistance transporter, EmrB QacA subfamily 0XNN3 Cluster_563733 V1227168 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_629069 V1227169 S NA 0YNJV Cluster_695934 V1227170 PROC map00330,map01100,map01110,map01230 E pyrroline-5-carboxylate reductase COG0345 Cluster_563734 V1227172 PTRB map05142,map05143 E Oligopeptidase b COG1770 Cluster_563735 V1227173 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_692118 V1227175 TRPD map00400,map01100,map01110,map01230 E anthranilate phosphoribosyltransferase COG0547 Cluster_563736 V1227177 PPAC map00190 C Manganese-dependent inorganic pyrophosphatase COG1227 Cluster_563737 V1227179 PHOA map00521,map00627,map00790,map01100,map01110,map01120,map02020 P alkaline phosphatase COG1785 Cluster_563738 V1227180 OTSA map00500,map01100 G alpha-alpha-trehalose-phosphate synthase COG0380 Cluster_724912 V1227181 UVRA2 map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_563739 V1227182 DXS map00730,map00900,map01100,map01110 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) COG1154 Cluster_563740 V1227183 ACCC map00061,map00253,map00620,map00640,map00720,map01100,map01110,map01120 I Biotin carboxylase COG0439 Cluster_563741 V1227184 S Transmembrane domain of unknown function (DUF3566) 11X32 Cluster_563743 V1227186 AFTD S coagulation factor 5 8 type domain-containing protein 0YR9E Cluster_563745 V1227190 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_563747 V1227192 S NA 0YH2T Cluster_563748 V1227193 K DNA-binding helix-turn-helix protein 11XIQ Cluster_563750 V1227196 SCLAV_1827 G extracellular solute-binding protein family 1 0XSR6 Cluster_566920 V1227197 M cell wall-binding protein COG2247 Cluster_640955 V1227198 NFED O, U Membrane protein implicated in regulation of membrane protease activity COG1585 Cluster_721567 V1227199 DEAD map03018 L ATP-dependent RNA helicase COG0513 Cluster_563752 V1227201 CYDA map00190,map01100,map02020 C (Ubiquinol oxidase) subunit I COG1271 Cluster_879989 V1227202 NBCG_03603 S Protein of unknown function (DUF3027) 11G10 Cluster_851789 V1227203 PBUG S Xanthine uracil vitamin C permease COG2252 Cluster_563753 V1227204 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_824731 V1227205 PRMA J Methylates ribosomal protein L11 (By similarity) COG2264 Cluster_711617 V1227207 SCLAV_5538 S NA 11XKE Cluster_563754 V1227212 EMBC M Arabinosyltransferase 0XSQE Cluster_563755 V1227214 PROB map00330,map01100,map01230 E Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) COG0263 Cluster_563756 V1227215 AMYA2 map00500 G alpha amylase, catalytic 0XQRS Cluster_610477 V1227216 INFC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) COG0290 Cluster_648878 V1227220 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_738050 V1227222 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_875956 V1227225 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_721568 V1227226 SMPB O Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) COG0691 Cluster_566922 V1227227 GDH map00250,map00330,map00430,map00910,map01100 E Dehydrogenase COG2902 Cluster_566923 V1227228 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_563758 V1227229 RPFB L domain protein COG3583 Cluster_800933 V1227230 map00980,map04976,map05204 S Hydrolase COG0596 Cluster_566924 V1227231 SSDA map00250,map00350,map00650,map01100,map01120 C Dehydrogenase COG1012 Cluster_563759 V1227233 RLUD J Pseudouridine synthase COG0564 Cluster_585969 V1227234 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_748125 V1227235 SP_1245 S hydrolase COG0561 Cluster_563760 V1227237 V Type I restriction modification DNA specificity domain COG0732 Cluster_566925 V1227239 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_566927 V1227241 YHGE S domain protein COG1511 Cluster_566928 V1227242 ALST map02020 E Sodium alanine symporter COG1115 Cluster_563762 V1227245 M Outer membrane porin 17VUU@proNOG Cluster_644813 V1227247 S NA 124KR Cluster_566930 V1227248 GLGE map00500,map01100,map04973 G Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) COG0366 Cluster_816931 V1227252 CBPA O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_789254 V1227253 map03430 L Adenine-specific COG3392 Cluster_566932 V1227255 SURB S G5 domain protein 0ZVV3 Cluster_566933 V1227256 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_796996 V1227257 MGTA map00051 M Glycosyl transferase (Group 1 COG0438 Cluster_836168 V1227258 UBIE map00130,map01100,map01110 H Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) COG2226 Cluster_800935 V1227261 COMEB map00240,map01100 F deaminase COG2131 Cluster_566935 V1227264 S Membrane COG4129 Cluster_758525 V1227265 SPOVK O AAA ATPase, central domain protein COG0464 Cluster_699216 V1227266 S Pfam:Complex1_24kDa 0XVAK Cluster_566936 V1227267 L Resolvase COG1961 Cluster_566937 V1227268 GLGB map00500,map01100,map01110 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) COG0296 Cluster_566938 V1227269 ENTC map00130,map01053,map01100,map01110 H Isochorismate synthase COG1169 Cluster_566940 V1227276 THRE S Amino acid export carrier protein COG3610 Cluster_579545 V1227277 MT0582 S conserved TRANSMEMBRANE PROTEIN 11TI5 Cluster_566941 V1227278 PEPA map00480,map01100 E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) COG0260 Cluster_566942 V1227279 HSDM V Type I restriction-modification system, M subunit COG0286 Cluster_871850 V1227281 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_569998 V1227282 TYRA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydrogenase COG0287 Cluster_614141 V1227283 E solute symporter COG0591 Cluster_566943 V1227286 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_569999 V1227287 YACP J Tetracycline resistance protein COG3688 Cluster_570000 V1227290 NRFA map00910,map01120,map05132 P Plays a role in nitrite reduction (By similarity) COG3303 Cluster_762288 V1227292 YBIT S ABC transporter COG0488 Cluster_648879 V1227293 PKS13 Q PKS_AT COG3321 Cluster_731495 V1227294 P tonB-dependent receptor plug 0YT3X Cluster_566944 V1227295 FTSI map00550,map01100 M Penicillin-binding Protein COG0768 Cluster_570001 V1227297 G Major Facilitator superfamily 0XT9M Cluster_570002 V1227299 map02030,map02040 M Ompa motb domain protein COG2885 Cluster_674187 V1227300 map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_734707 V1227302 MVAD map00900,map01100,map01110 I diphosphomevalonate decarboxylase COG3407 Cluster_566946 V1227304 TRPC map00400,map01100,map01110,map01230 E Indole-3-glycerol phosphate synthase COG0135 Cluster_566947 V1227306 METX map00270,map00920,map01100 E Homoserine O-trans-acetylase COG2021 Cluster_566948 V1227308 map00630,map01100,map01110 F IA, variant 1 COG0546 Cluster_570004 V1227311 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_570005 V1227312 GDHA map00250,map00330,map00910,map01100 E Glutamate dehydrogenase COG0334 Cluster_665479 V1227313 RPOZ map00230,map00240,map01100,map03020 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) COG1758 Cluster_570006 V1227314 IRP6A map02010 P Periplasmic binding protein COG0614 Cluster_570007 V1227316 T response regulator COG2197 Cluster_570008 V1227317 SCLAV_1045 S Membrane COG3346 Cluster_566950 V1227318 MAQU_3187 L Integrase catalytic subunit COG4584 Cluster_796997 V1227319 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_566951 V1227321 PRPD map00640 S 2-methylcitrate dehydratase COG2079 Cluster_904923 V1227322 SP_1473 S UPF0291 protein COG4224 Cluster_570009 V1227323 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_570010 V1227324 H Transporter COG2978 Cluster_744776 V1227326 PURE map00230,map01100,map01110 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) COG0041 Cluster_820745 V1227327 S Pfam:SirA 0ZMJP Cluster_813156 V1227328 S Protein of unknown function (DUF3343) 0ZXTN Cluster_566952 V1227329 S Inherit from COG: oxidoreductase 0XPNK Cluster_570013 V1227332 S Rib/alpha-like repeat 10008 Cluster_769985 V1227334 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_570015 V1227337 VSR L DNA mismatch endonuclease (vsr) COG3727 Cluster_566954 V1227338 map00260,map01100 C pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_781129 V1227341 E Peptidase, S9A B C family, catalytic domain protein COG1506 Cluster_589287 V1227342 RLUD J Pseudouridine synthase COG0564 Cluster_570016 V1227343 S NA 0ZMKZ Cluster_570018 V1227346 S transglutaminase domain-containing protein 0XQP2 Cluster_570019 V1227348 PPX1 map00230 F, P ppx gppa phosphatase COG0248 Cluster_570020 V1227349 S Membrane COG3949 Cluster_755003 V1227350 C reductase COG0656 Cluster_570021 V1227351 MT1736 S thiamin pyrophosphokinase catalytic COG4825 Cluster_570022 V1227353 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG3848 Cluster_665480 V1227355 SUCB map00010,map00020,map00280,map00310,map00620,map01100,map01110,map01120 C 2-oxoglutarate dehydrogenase E2 component, dihydrolipoamide succinyltransferase COG0508 Cluster_678628 V1227356 map00051 M glycosyltransferase group 2 family protein COG0463 Cluster_579546 V1227357 LPQU M MemBrane-bound lytic murein transglycosylase COG2951 Cluster_570025 V1227359 PVDS map00190,map03018 L polyphosphate kinase 2 COG2326 Cluster_632895 V1227360 DXR map00900,map01100,map01110 I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) COG0743 Cluster_573209 V1227362 B565_1256 S NA 11JBM Cluster_731496 V1227363 DDH map00300,map01100,map01110,map01230 E Diaminopimelate dehydrogenase 0XPX2 Cluster_570026 V1227364 GLNE O, T Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) COG1391 Cluster_652952 V1227365 K Phage antirepressor protein KilAC domain COG3645 Cluster_573210 V1227366 AHPF O Alkyl hydroperoxide reductase COG3634 Cluster_570027 V1227368 LKTB3 V ABC transporter, ATP-binding protein COG2274 Cluster_610478 V1227369 CAS5 L CRISPR-associated protein Cas5 0ZS6C Cluster_573211 V1227370 U, W surface protein COG5295 Cluster_570028 V1227371 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_570029 V1227374 ARTH_4141 map00620 C d-lactate dehydrogenase COG0277 Cluster_570030 V1227375 CAPA M Capsule synthesis protein COG2843 Cluster_648880 V1227376 DPPD map02010 E, P (ABC) transporter COG0444 Cluster_570031 V1227377 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_570032 V1227380 S NA 11F3W Cluster_573212 V1227381 PDXK map00750,map01100 H Pyridoxal kinase COG2240 Cluster_570033 V1227382 Q Nonribosomal peptide synthase COG1020 Cluster_573213 V1227383 LMRS P Transporter 0ZVUY Cluster_570035 V1227385 SHC P drug resistance transporter, EmrB QacA subfamily 0XNN3 Cluster_570036 V1227386 M hydrolase COG3409 Cluster_573214 V1227387 YCEG F aminodeoxychorismate lyase COG1559 Cluster_573216 V1227389 GLTA map00250,map00910,map01100,map01110,map01120,map01230 E glutamate synthase COG0493 Cluster_734709 V1227390 S NA 0XSQY Cluster_573217 V1227393 GATC2 map00052,map01100,map02060 G PTS system, galactitol-specific IIc component COG3775 Cluster_570037 V1227395 PEPN map00480,map01100 E Aminopeptidase COG0308 Cluster_592638 V1227405 YQFA S UPF0365 protein COG4864 Cluster_674188 V1227406 E peptidase 0XRNU Cluster_570039 V1227407 S NA 0ZH30 Cluster_570040 V1227408 GST map00480,map00980,map00982,map05204 O Glutathione S-transferase COG0625 Cluster_705384 V1227409 GATB map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 Cluster_570041 V1227410 TRPD map00400,map01100,map01110,map01230 E anthranilate phosphoribosyltransferase COG0547 Cluster_570042 V1227411 K RNA Polymerase COG1595 Cluster_796998 V1227412 HTRA map03010 M peptidase S1 and S6, chymotrypsin Hap COG0265 Cluster_573220 V1227413 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_573221 V1227414 HRPA L ATP-dependent helicase COG1643 Cluster_824732 V1227415 map05150 S Uncharacterized conserved protein (DUF2156) COG2898 Cluster_867911 V1227416 L adenine specific DNA methyltransferase COG4889 Cluster_570043 V1227417 S membrane protein, AbrB duplication COG3180 Cluster_573222 V1227419 SUFB O FeS assembly protein SUFB COG0719 Cluster_573223 V1227420 PITA P phosphate transporter COG0306 Cluster_573224 V1227422 FRUA map00051,map01100,map02060 G PTS System COG1762 Cluster_573225 V1227423 MT3294 P TrkA-N domain protein COG1226 Cluster_573226 V1227424 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG0194 Cluster_573228 V1227426 GLTA map00020,map00630,map00640,map01100,map01110,map01120,map01210,map01230 C citrate synthase COG0372 Cluster_644814 V1227427 L NA 1004T Cluster_573229 V1227428 ILVD map00290,map00770,map01100,map01110,map01210,map01230 E Dihydroxy-acid dehydratase COG0129 Cluster_617897 V1227429 AROQ map00400,map01100,map01110,map01230 E Catalyzes a trans-dehydration via an enolate intermediate (By similarity) COG0757 Cluster_596123 V1227432 map00564,map00730 C fad dependent oxidoreductase COG0579 Cluster_573230 V1227433 NRDE map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_674189 V1227436 SCLAV_3101 S Inherit from NOG: Transcriptional regulator, arsR family 11YC6 Cluster_589288 V1227437 OSTA M Organic solvent tolerance protein COG1452 Cluster_573233 V1227438 S nucleoside recognition domain protein COG3314 Cluster_585970 V1227439 FADA2 map00071,map00072,map00280,map00281,map00310,map00350,map00362,map00380,map00592,map00620,map00627,map00630,map00640,map00642,map00650,map00720,map00900,map00903,map01100,map01110,map01120,map02020 I Acetyl-COA acetyltransferase COG0183 Cluster_573234 V1227440 S Protein of unknown function (DUF524) COG1700 Cluster_820746 V1227441 GLTB map00250,map00630,map00910,map01100,map01110,map01120,map01230 E Glutamate synthase COG0070 Cluster_573235 V1227442 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_573236 V1227444 FRUA map00051,map01100,map02060 G PTS System COG1762 Cluster_665481 V1227445 S NA 0YF67 Cluster_576439 V1227446 YHAM S Metal Dependent Phosphohydrolase COG3481 Cluster_573237 V1227448 map00350,map00362,map00627,map00642,map00903,map01120 K acetyltransferase COG0454 Cluster_573238 V1227449 NUSA K Transcription elongation factor NusA COG0195 Cluster_573239 V1227453 PURF map00230,map00250,map01100,map01110 F glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_661305 V1227457 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_606819 V1227458 S Membrane COG1289 Cluster_816933 V1227460 META map00270,map00920,map01100,map01110,map01230 E Homoserine O-transsuccinylase COG1897 Cluster_573241 V1227461 MT3296 L helicase COG2887 Cluster_661306 V1227462 DNAJ1 O DnaJ domain protein COG0484 Cluster_576441 V1227463 HEMG map00860,map01100,map01110 H protoporphyrinogen oxidase COG1232 Cluster_576442 V1227464 CHEA map02020,map02030 T CheA Signal Transduction Histidine COG0643 Cluster_576443 V1227467 GLPF G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) COG0580 Cluster_573242 V1227468 M domain protein COG4932 Cluster_708481 V1227469 BMUL_1547 K Transcriptional regulator 0XUB6 Cluster_576444 V1227470 map03440 K Transcriptional regulator COG2865 Cluster_573243 V1227472 AFTB S Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids 0YKVT Cluster_576446 V1227474 ARGD map00300,map00330,map01100,map01110,map01120,map01210,map01230 E Acetylornithine aminotransferase COG4992 Cluster_695935 V1227475 SSCG_03030 map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_576447 V1227476 K Transcriptional regulator COG0789 Cluster_573244 V1227478 T UspA domain-containing protein COG0589 Cluster_576449 V1227479 ATPG map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) COG0224 Cluster_576450 V1227480 RUVA map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) COG0632 Cluster_589289 V1227481 GLNQ map02010,map02020 E (ABC) transporter COG1126 Cluster_576451 V1227482 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Involved in acetate metabolism (By similarity) COG0280 Cluster_576452 V1227487 IDSA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_718244 V1227493 ANT_21360 S Pin domain protein 124IH Cluster_576455 V1227494 VIRB8 map03070 U Type IV secretion system protein VirB8 COG3736 Cluster_576456 V1227497 HUTU map00340,map01100 E Urocanate hydratase COG2987 Cluster_731497 V1227499 AGCS E Sodium:alanine symporter family COG1115 Cluster_576458 V1227503 S NA 0XXJW Cluster_576459 V1227504 THIJ S intracellular protease Pfpi family COG0693 Cluster_741469 V1227506 S Protein of unknwon function (DUF3310) 0XVU3 Cluster_582784 V1227507 YGDL H uba thif-type nad fad binding protein COG1179 Cluster_832272 V1227509 PFOR S Membrane COG3641 Cluster_636931 V1227511 DCM2 map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_610479 V1227513 I thioesterase Superfamily protein COG1607 Cluster_576460 V1227514 L site-specific recombinase, phage integrase family 0ZQ44 Cluster_576461 V1227515 TRPC map00400,map01100,map01110,map01230 E Indole-3-glycerol phosphate synthase COG0134 Cluster_576462 V1227516 M Cell wall anchor domain protein 129AF Cluster_576463 V1227517 METQ map02010 P (LipO)protein COG1464 Cluster_762289 V1227521 RUVA map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) COG0632 Cluster_576465 V1227522 ASPA map00250,map00910,map01100 E Aspartate ammonia-lyase COG1027 Cluster_789255 V1227523 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_576466 V1227525 TPAU_0254 L Integrase COG2801 Cluster_632896 V1227526 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_789256 V1227529 Q Inherit from COG: depolymerase COG3509 Cluster_579548 V1227530 PYC map00020,map00620,map00720,map01100,map01120,map01230 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) COG1038 Cluster_576468 V1227531 S Lipopolysaccharide kinase (Kdo/WaaP) family 0XRBE Cluster_579549 V1227535 map00361,map00623,map00627,map01120 C, H Phenol 2-monooxygenase COG0654 Cluster_741470 V1227536 map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_621573 V1227539 MSHD S Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) COG0456 Cluster_714993 V1227540 S NA 0Z81Q Cluster_576470 V1227543 MRPA map00190 P monovalent cation H antiporter subunit A COG2111 Cluster_652953 V1227544 map02010 P Periplasmic binding protein COG0614 Cluster_576471 V1227545 SUGB G extracellular solute-binding protein family 1 COG1653 Cluster_913245 V1227547 S secreted protein 11S0R Cluster_576472 V1227548 GULO map00053,map01100 C oxidoreductase COG0277 Cluster_576473 V1227549 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_579550 V1227550 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_579551 V1227552 SENX3 map02020 T Histidine kinase 0XNMH Cluster_579552 V1227553 S repeat protein 11IAG Cluster_793051 V1227554 S SusD family 0XPTK Cluster_661307 V1227555 METK S methionine adenosyltransferase 0YTXD Cluster_640956 V1227559 S abc transporter atp-binding protein 11HXT Cluster_809173 V1227561 GLPG S Rhomboid family COG0705 Cluster_576474 V1227562 S Phage infection protein COG1511 Cluster_579553 V1227565 S NA 12B83 Cluster_576475 V1227566 CAPD map00052,map00362,map00363,map00520,map00626,map00650,map00903,map01100,map01110,map01120 M Polysaccharide biosynthesis protein COG1086 Cluster_728188 V1227567 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG0469 Cluster_579554 V1227568 MEGL map00260,map00270,map00450,map00920,map01100,map01110,map01230 E methionine gamma-lyase COG0626 Cluster_625351 V1227571 Q amino acid adenylation domain protein COG1020 Cluster_579557 V1227573 S NA 11NJX Cluster_579558 V1227574 SCLAV_2561 O serine protease COG0265 Cluster_579560 V1227576 PPSA map00620,map00680,map00710,map00720,map01100,map01120 G pyruvate COG0574 Cluster_579561 V1227578 MGTE P magnesium transporter COG2239 Cluster_800937 V1227580 RV2242 K Transcriptional regulator COG2508 Cluster_579562 V1227582 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_579563 V1227584 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG0469 Cluster_579565 V1227586 NSPC map00330 E Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) COG0019 Cluster_738054 V1227588 S interferon-induced transmembrane protein 121MN Cluster_648882 V1227589 S NA 11H7Q Cluster_579567 V1227590 NIRK map00910,map01120 Q nitrite reductase COG2132 Cluster_579568 V1227591 AFTD S coagulation factor 5 8 type domain-containing protein 0YR9E Cluster_579569 V1227592 RHLE map03018 L atp-dependent rna helicase COG0513 Cluster_582785 V1227593 S NA 101UU Cluster_579570 V1227594 PYRB map00240,map00250,map01100 F aspartate transcarbamylase COG0540 Cluster_582786 V1227597 BL00983 S Phage Portal Protein 11QNG Cluster_913247 V1227598 S Replication initiator protein 11Z32 Cluster_579572 V1227599 AARI_35290 L integrase catalytic COG2801 Cluster_582787 V1227600 PAAG I Enoyl-CoA hydratase COG1024 Cluster_585971 V1227601 BL01965 S trap transporter, 4tm 12tm fusion protein COG4666 Cluster_582788 V1227602 HSDR V type I restriction-modification system COG0610 Cluster_687595 V1227603 S NA 1249W Cluster_579573 V1227605 CMK map00240,map00410,map00770,map01100,map01110 F Cytidine monophosphate kinase COG0283 Cluster_692119 V1227606 CASE L crispr-associated protein 0XPHC Cluster_579574 V1227608 XDHA map00230,map01100,map01120 C Xanthine dehydrogenase COG1529 Cluster_579576 V1227610 S Phage portal protein, SPP1 Gp6-like 0XRSA Cluster_582789 V1227612 YLME F alanine racemase domain protein COG0325 Cluster_579578 V1227618 G Major facilitator superfamily MFS_1 11MD0 Cluster_603205 V1227619 RBSB map02010,map02030 G Ribose ABC transporter COG1879 Cluster_582793 V1227621 PKNG map05152 T Serine Threonine protein kinase COG0515 Cluster_582794 V1227623 AFTB S Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids 0YKVT Cluster_582795 V1227625 BGLG K antiterminator COG3711 Cluster_582796 V1227626 S NA 11QA3 Cluster_705385 V1227628 YHCF K TRANSCRIPTIONAl REGULATOR GntR family COG1725 Cluster_592639 V1227629 S Methyltransferase domain protein 11HQ9 Cluster_669788 V1227633 map02010 V ABC transporter 0XPIZ Cluster_582798 V1227634 PURF map00230,map00250,map01100,map01110 F glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_708483 V1227636 ATPC map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG0355 Cluster_582799 V1227639 DOTL S NA 16TD2@proNOG Cluster_582800 V1227640 map02010 G ABC transporter COG3839 Cluster_582801 V1227642 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_582802 V1227643 L Resolvase COG1961 Cluster_582803 V1227644 PLSC map00561,map00564,map01100 I Acyl-transferase 0Z3QU Cluster_582804 V1227650 HCP C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) COG1151 Cluster_582805 V1227651 MTLK map02010 G Abc transporter COG3839 Cluster_840041 V1227652 ILVN map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E Acetolactate synthase small subunit COG0440 Cluster_867913 V1227653 ILVC map00290,map00770,map01100,map01110,map01210,map01230 E Alpha-keto-beta-hydroxylacyl reductoisomerase COG0059 Cluster_582806 V1227654 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_871851 V1227657 S Membrane COG1811 Cluster_582807 V1227658 PROC map00330,map01100,map01110,map01230 E pyrroline-5-carboxylate reductase COG0345 Cluster_582808 V1227659 ECTP P Transporter COG1292 Cluster_582809 V1227661 S phage-like element pbsx protein xkdK 0ZVHW Cluster_610482 V1227662 ARGS map00970 J arginyL-tRNA synthetase COG0018 Cluster_652954 V1227663 S NA 11WZP Cluster_582810 V1227664 PLSC map00561,map00564,map01100 I Acyl-transferase 0Z3QU Cluster_582811 V1227666 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_632897 V1227667 FABG2 map00061,map00630,map00650,map00780,map01040,map01100,map01120 I reductase 0XNW1 Cluster_840042 V1227668 YGHZ map00051,map00363,map00591,map00625,map00650,map01100,map01120 C Aldo keto reductase COG0667 Cluster_582813 V1227670 ARGJ map00330,map01100,map01110,map01210,map01230 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) COG1364 Cluster_766255 V1227671 S NA 188HG@proNOG Cluster_714994 V1227673 U, W domain protein COG5295 Cluster_728190 V1227675 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_832273 V1227676 L Transposase COG2963 Cluster_585972 V1227677 map02020 T Histidine kinase COG0642 Cluster_582815 V1227678 YBEY S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) COG0319 Cluster_582816 V1227679 S Relaxase mobilization nuclease 0Y9PG Cluster_582817 V1227680 S Inherit from COG: Fusaric acid resistance protein COG1289 Cluster_582818 V1227681 M Alpha beta hydrolase fold COG1073 Cluster_644815 V1227682 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_711619 V1227684 MSRA O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) COG0225 Cluster_769986 V1227688 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_585973 V1227689 BCGIA V Type II restriction modification enzyme methyltransferase COG0286 Cluster_711620 V1227691 K transcriptional regulator 126ZB Cluster_585974 V1227692 SP_0913 V ABC transporter (Permease COG0577 Cluster_589290 V1227693 MNHD P subunit D COG0651 Cluster_582821 V1227694 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_582823 V1227699 RLPA M rare lipoprotein A COG0797 Cluster_585975 V1227700 S Rib/alpha-like repeat 10008 Cluster_731499 V1227702 QCRA P rieske 2fe-2S domain-containing protein COG2146 Cluster_585976 V1227703 P drug resistance transporter, Bcr CflA 0XNNX Cluster_632898 V1227704 S repeat protein 11IAG Cluster_582824 V1227706 CLPB O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity COG0542 Cluster_777389 V1227707 map00360,map00362,map00621,map00622,map01100,map01120 Q hydratase COG3971 Cluster_582826 V1227710 S NA 11K9E Cluster_687596 V1227711 ILVX map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E, H thiamine pyrophosphate COG0028 Cluster_585978 V1227712 SURB S G5 domain protein 0ZVV3 Cluster_585979 V1227714 AMAA map00360 E Peptidase dimerisation domain COG1473 Cluster_585980 V1227715 SARE_3729 L phage plasmid primase, p4 family COG3378 Cluster_582827 V1227717 AMYE map02010 G solute-binding protein COG1653 Cluster_734710 V1227719 ZWF map00030,map00480,map01100,map01110,map01120 G glucose-6-phosphate 1-dehydrogenase COG0364 Cluster_731500 V1227720 CSPB K Cold shock protein COG1278 Cluster_582828 V1227721 L Inherit from COG: Resolvase COG1961 Cluster_621574 V1227723 USPA S UspA domain-containing protein 16SIA@proNOG Cluster_762292 V1227724 PURM map00230,map01100,map01110 F Phosphoribosylformylglycinamidine cyclo-ligase COG0150 Cluster_585983 V1227725 YLQF K Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) COG1161 Cluster_585984 V1227726 ATPB map00190,map00195,map01100 C it plays a direct role in the translocation of protons across the membrane (By similarity) COG0356 Cluster_592640 V1227727 YEBA M peptidase COG0739 Cluster_585985 V1227729 CAS3 L CRISPR-associated helicase, cas3 COG1203 Cluster_692120 V1227731 RPFA S Resuscitation-promoting factor 11WB2 Cluster_714996 V1227732 map02010 E (ABC) transporter COG4608 Cluster_744777 V1227735 S Membrane 0Y0H4 Cluster_585988 V1227736 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_585989 V1227737 map00360,map00362,map00650,map01100,map01120 I 3-hydroxyacyl-CoA dehydrogenase COG1250 Cluster_585991 V1227741 map00230,map00240,map00410,map00770,map00983,map01100,map01120 F K01464 dihydropyrimidinase EC 3.5.2.2 COG0044 Cluster_585993 V1227743 HUTI map00340,map01100 Q imidazolone-5-propionate hydrolase COG1228 Cluster_809174 V1227747 MCSB map00330 E ATP guanido phosphotransferase COG3869 Cluster_585994 V1227749 CSTA T carbon starvation protein COG1966 Cluster_585996 V1227751 FTSK D cell division protein FtsK COG1674 Cluster_585997 V1227752 HEMD map00860,map01100,map01110 H Uroporphyrinogen-III Synthase COG1587 Cluster_585998 V1227753 S integral membrane protein COG3182 Cluster_586001 V1227756 BL00235 map00240,map00250,map00330,map01100,map01110,map01230 I domain protein COG0439 Cluster_586002 V1227757 S NA 11MPN Cluster_793053 V1227761 TATA map03060,map03070 U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) 17RH3@proNOG Cluster_586003 V1227763 SCLAV_0672 P integral membrane protein COG1253 Cluster_928914 V1227765 L phage-type endonuclease COG5377 Cluster_871852 V1227767 WBLA K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) 11W0R Cluster_859578 V1227768 SCLAV_2569 S NA 121W6 Cluster_589291 V1227770 L SNF2 family N-terminal domain COG0553 Cluster_586005 V1227771 L NA 100GZ Cluster_586006 V1227772 T Histidine kinase 0XNMH Cluster_589292 V1227774 map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_586007 V1227775 S Membrane COG3949 Cluster_586008 V1227776 S NA 11QZ9 Cluster_586009 V1227777 RNFC C Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) COG4656 Cluster_629071 V1227783 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_589293 V1227784 YWMD S von Willebrand factor, type A COG2304 Cluster_586010 V1227785 E amino acid carrier protein COG1115 Cluster_714998 V1227786 SSNA F selenium metabolism protein SsnA COG0402 Cluster_586011 V1227787 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_832274 V1227789 YEDF map04122 S selenium metabolism protein yedf 179WR@proNOG Cluster_586012 V1227790 APPB map02010 P Binding-protein-dependent transport systems inner membrane component COG0601 Cluster_589294 V1227791 S NA 11NCS Cluster_589295 V1227792 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_586014 V1227794 GALU map00040,map00052,map00500,map00520,map01100,map01110 M UTP-glucose-1-phosphate uridylyltransferase COG1210 Cluster_589296 V1227795 KEFB P glutathione-regulated potassium-efflux system protein COG4651 Cluster_589298 V1227798 HELY L helicase COG4581 Cluster_589299 V1227799 FABF map00061,map00780,map01100 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) COG0304 Cluster_589300 V1227800 PSTS map02010,map02020,map05152 P Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) COG0226 Cluster_486782 V1022601 MOAC map00790,map01100,map04122 H Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) COG0315 Cluster_432576 V1022603 ISOVA_0221 V HNH endonuclease 11RVB Cluster_460465 V1022605 S Domain of unknown function (DUF1896) 0YAGN Cluster_199690 V1022610 O Peptidyl-prolyl cis-trans isomerase 0XT59 Cluster_392600 V1022611 S NA 0ZHU9 Cluster_289770 V1022613 FHUC map02010 P ABC transporter COG1120 Cluster_434463 V1022615 S NA 11EQP Cluster_378473 V1022616 COBH map00860,map01100 H Precorrin-8x methylmutase COG2082 Cluster_831314 V1022618 map02010 M Efflux ABC transporter, permease protein COG4591 Cluster_292373 V1022621 RPH map00230,map00240,map01100 J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) COG0689 Cluster_588483 V1022623 DHAM G Dihydroxyacetone kinase COG3412 Cluster_501741 V1022624 S NA 0XWWS Cluster_643899 V1022625 YCGK K Transcriptional regulator 0XNR2 Cluster_514526 V1022626 YCGK K Transcriptional regulator 0XNR2 Cluster_231054 V1022627 ATPG map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) COG0224 Cluster_470996 V1022628 P TonB-dependent receptor Plug 0XP8A Cluster_489070 V1022629 THIN map00730,map01100 H thiamine COG1564 Cluster_677637 V1022630 S NA 11EMQ Cluster_442552 V1022631 I Acyltransferase COG0204 Cluster_383742 V1022632 S NA 0YH5F Cluster_201685 V1022634 HELY L helicase COG4581 Cluster_430579 V1022635 AHPC O Peroxiredoxin COG0450 Cluster_201686 V1022636 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_201687 V1022637 S Membrane 0Y2EP Cluster_264084 V1022640 FTSX map02010 D Cell division protein FtsX COG2177 Cluster_647921 V1022643 S NA 11QQB Cluster_218224 V1022644 L DNA helicase COG1112 Cluster_847158 V1022645 S NA 0ZHU9 Cluster_899588 V1022646 S NA 11EJA Cluster_202724 V1022647 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_562967 V1022653 map03030,map03430,map03440 L single-stranded DNA-binding protein 0XYIK Cluster_578766 V1022658 S NA 0ZHU9 Cluster_269501 V1022660 map04112 L DNA methylase n-4 n-6 domain protein COG0863 Cluster_337800 V1022665 PCS map00564 I Phosphatidylcholine synthase COG1183 Cluster_470997 V1022666 DEF J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) COG0242 Cluster_301959 V1022667 CATE S Glyoxalase Bleomycin resistance protein (Dioxygenase COG2514 Cluster_454554 V1022670 L decarboxylase COG1611 Cluster_438553 V1022673 RNPA J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) COG0594 Cluster_415805 V1022674 THIJ map05012 T DJ-1 family COG0693 Cluster_371633 V1022675 DCK map00230,map00240,map01100 F deoxynucleoside kinase COG1428 Cluster_383743 V1022676 RPLY map03010 J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) COG1825 Cluster_765300 V1022677 S NA 0Y226 Cluster_423006 V1022680 K RNA polymerase 11UU1 Cluster_517246 V1022682 FUCU G RbsD or FucU transport COG4154 Cluster_554130 V1022684 S Tetratricopeptide repeat protein COG0457 Cluster_421152 V1022685 ETFA map00910 C electron transfer flavoprotein alpha subunit COG2025 Cluster_462589 V1022687 RPLJ map03010 J 50s ribosomal protein L10 COG0244 Cluster_470998 V1022688 map00511 S (LipO)protein 0Y1KT Cluster_351762 V1022689 S ABC transporter COG4152 Cluster_406710 V1022694 VIOA map00362,map00363,map00626,map00650,map00903,map01100,map01110,map01120 E DegT DnrJ EryC1 StrS COG0399 Cluster_551262 V1022695 S domain protein 0YNW0 Cluster_330211 V1022696 AGNC map00531,map01100,map04142 S Alpha-N-acetylglucosaminidase 0XNMK Cluster_827728 V1022701 S Protein of unknown function (DUF3073) 0XUJ2 Cluster_479825 V1022702 SCLAV_2918 S integral membrane protein 11X32 Cluster_208156 V1022703 ATL G the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis COG5632 Cluster_473123 V1022704 RECX S regulatory protein RecX 11Y5X Cluster_394346 V1022705 S (LipO)protein 0ZCQY Cluster_273470 V1022706 SUHB G inositol mono-phosphatase COG0483 Cluster_551263 V1022709 S integral membrane protein 126AA Cluster_460466 V1022710 S NA 0ZHCU Cluster_578767 V1022714 K Transcriptional regulator, luxr family 0XUEY Cluster_243651 V1022724 SUFB O FeS assembly protein SUFB COG0719 Cluster_562968 V1022725 SP_0104 map00630,map01100,map01110 S Hydrolase COG0546 Cluster_482157 V1022726 WZB T protein tyrosine phosphatase COG0394 Cluster_434464 V1022729 DEF J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) COG0242 Cluster_250071 V1022730 LIPA map00785,map01100 H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) COG0320 Cluster_211389 V1022735 S Protein of unknown function DUF262 10XAM Cluster_228721 V1022736 M Cell Wall COG5263 Cluster_452517 V1022737 LMRB G resistance protein 0XNN3 Cluster_306291 V1022738 S Transposition protein 17B81@proNOG Cluster_211391 V1022749 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_282847 V1022750 map00051 M Glycosyl transferase (Group 1 COG0438 Cluster_300551 V1022751 PRFC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) COG4108 Cluster_539531 V1022753 map00790,map01100 H synthase COG0720 Cluster_394347 V1022755 RSMG M Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) COG0357 Cluster_212498 V1022759 L helicase COG4646 Cluster_389067 V1022760 PYRE map00240,map00983,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_514527 V1022761 S NA 177DA@proNOG Cluster_292374 V1022762 O DnaJ domain protein COG1076 Cluster_212499 V1022763 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_444559 V1022764 L DNA helicase COG1112 Cluster_299218 V1022765 BATD S BatD protein 0XR99 Cluster_737202 V1022766 RPST map03010 J Binds directly to 16S ribosomal RNA (By similarity) 1220Z Cluster_363229 V1022767 M Ompa motb domain protein COG2885 Cluster_682174 V1022769 YERC S protein, YerC YecD COG4496 Cluster_424784 V1022771 YBHB S phospholipid-binding protein COG1881 Cluster_432577 V1022773 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_265430 V1022774 RHLE map03018 L atp-dependent rna helicase COG0513 Cluster_218225 V1022775 S Tetratricopeptide repeat protein COG0457 Cluster_710828 V1022781 OPCA G OpcA protein COG3429 Cluster_484469 V1022782 FTN map00860 P ferritin COG1528 Cluster_217109 V1022790 LACC map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G tagatose-6-phosphate kinase COG1105 Cluster_217110 V1022794 OPRJ map02020 M RND efflux system, outer membrane lipoprotein COG1538 Cluster_486783 V1022795 BAIA map00061,map00362,map00780,map01040,map01100,map01120,map01220 S Bile acid 7-dehydroxylase 1 3 0XNW1 Cluster_602325 V1022796 K Transcriptional regulator 0YPRW Cluster_484470 V1022797 COAD map00770,map01100 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) COG0669 Cluster_217111 V1022799 S phage portal protein, SPP1 0ZZDC Cluster_586015 V1227801 S Membrane COG3949 Cluster_586016 V1227802 K, L domain protein COG0553 Cluster_603207 V1227804 T Two component transcriptional regulator, winged helix family COG0745 Cluster_589301 V1227805 BL01323 M Cell wall binding repeat 2-containing protein 0ZKZU Cluster_820747 V1227809 S -acetyltransferase COG2388 Cluster_589303 V1227811 INLJ map05150 M Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps 1215X Cluster_586017 V1227812 SP_0341 S UPF0371 protein COG4868 Cluster_586018 V1227813 V type II restriction enzyme, methylase subunit COG1002 Cluster_614142 V1227814 MT0582 S conserved TRANSMEMBRANE PROTEIN 11TI5 Cluster_589304 V1227815 MT0425 S secreted protein 10SG5 Cluster_705387 V1227816 PACL P Cation transporting ATPase, C-terminus COG0474 Cluster_589306 V1227819 GLF M udp-galactopyranose mutase COG0562 Cluster_586019 V1227822 PPNK map00760,map01100 G Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) COG0061 Cluster_589308 V1227824 CZCD P cation diffusion facilitator family transporter COG1230 Cluster_589309 V1227825 TMP1 S NA 10C99 Cluster_589310 V1227827 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_589313 V1227830 V Mate efflux family protein COG0534 Cluster_661308 V1227832 S NA 0ZHU9 Cluster_589314 V1227833 ETFA map00910 C Electron transfer flavoprotein COG2025 Cluster_589316 V1227835 map00521,map00523,map01100,map01110 M Nucleotidyl transferase COG1209 Cluster_589317 V1227836 P TonB-dependent receptor Plug COG4771 Cluster_589320 V1227840 RV1278 S growth 0ZW9I Cluster_610483 V1227841 L site-specific recombinase, phage integrase family 0ZF8H Cluster_589321 V1227842 M Putative cell wall binding repeat 2 COG2247 Cluster_789257 V1227843 P drug resistance transporter, Bcr CflA 0XNNX Cluster_674193 V1227844 BGR_03480 S hicB family 11WF0 Cluster_589322 V1227847 PARE L DNA topoisomerase IV (Subunit B) COG0187 Cluster_816935 V1227848 XTH map03410 L Exodeoxyribonuclease III COG0708 Cluster_592642 V1227851 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_592644 V1227854 S NA 0ZQ72 Cluster_592645 V1227855 RARA L recombination factor protein RarA COG2256 Cluster_589324 V1227856 E amidohydrolase COG1473 Cluster_589325 V1227857 PHOH T Phoh family COG1702 Cluster_592646 V1227858 PDXY map00750,map01100 H functions in a salvage pathway. Uses pyridoxamine (By similarity) COG2240 Cluster_589326 V1227860 CPN_0542 map02010 P ABC transporter COG1121 Cluster_793054 V1227863 HP1080 V restriction endonuclease COG1787 Cluster_832275 V1227866 MT3093 E amino acid-binding act 0ZHQE Cluster_592648 V1227867 MALQ map00500,map01100 G 4-alpha-glucanotransferase COG1640 Cluster_592649 V1227868 YCFI map02010 V abc transporter COG1132 Cluster_851791 V1227871 RPLK map03010 J This protein binds directly to 23S ribosomal RNA (By similarity) COG0080 Cluster_692121 V1227872 YRHK S NA 1237U Cluster_592650 V1227873 AMN map00230 F Amp nucleosidase COG0775 Cluster_589327 V1227876 DINB L Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) COG0389 Cluster_695937 V1227877 RPLD map03010 J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) COG0088 Cluster_692122 V1227878 S NA 120W9 Cluster_797002 V1227879 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_592653 V1227881 S Auxin Efflux Carrier COG0679 Cluster_592654 V1227883 AROB map00400,map01100,map01110,map01230 E 3-dehydroquinate synthase COG0337 Cluster_592655 V1227885 SCLAV_3021 S (twin-arginine translocation) pathway signal COG3211 Cluster_589329 V1227886 map00230 K, T Metal Dependent Phosphohydrolase COG0317 Cluster_625352 V1227888 MT3501 L polymerase involved in DNA repair COG0389 Cluster_665482 V1227892 GCVT map00260,map00670,map00910,map01100 E The glycine cleavage system catalyzes the degradation of glycine (By similarity) COG0404 Cluster_657082 V1227893 K regulatoR COG0745 Cluster_592658 V1227894 YBHK S UPF0052 protein COG0391 Cluster_592659 V1227895 S Domain of unknown function (DUF2017) 0XSEV Cluster_592660 V1227896 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_592661 V1227898 S NA 0ZHU9 Cluster_606821 V1227900 RPSA map00900,map01100,map01110,map03010 J Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) COG0761 Cluster_687598 V1227902 SCLAV_2561 O serine protease COG0265 Cluster_592662 V1227904 S NA 0YEUF Cluster_592663 V1227905 S membrAne 0XRY9 Cluster_592664 V1227906 PPSA S pyruvate phosphate dikinase 0XRDW Cluster_718245 V1227908 T UspA domain-containing protein COG0589 Cluster_592666 V1227909 MIND D site-determining protein COG2894 Cluster_592667 V1227910 RIBX S Pfam:DUF2581 11VXH Cluster_592668 V1227911 L dEAD DEAH box helicase COG1205 Cluster_592669 V1227912 CSEE S NA 0XUV8 Cluster_625353 V1227917 S RDD family 0Y3KW Cluster_592671 V1227918 S Pfam:DUF2081 COG3472 Cluster_648883 V1227919 S NA 0ZA04 Cluster_592672 V1227921 ARGF map00330,map01100,map01110,map01230 E ornithine carbamoyltransferase COG0078 Cluster_596125 V1227922 map01040 I acyl-CoA thioesterase COG1946 Cluster_596126 V1227923 PPIA O PPIases accelerate the folding of proteins (By similarity) COG0652 Cluster_592673 V1227924 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_592674 V1227925 OCAR_5156 E transglutaminase domain protein COG1305 Cluster_648884 V1227926 O Aaa family atpase COG0464 Cluster_592675 V1227927 LGAS_0610 S Major capsid protein 11IJY Cluster_596127 V1227929 SDAC E Serine transporter COG0814 Cluster_592676 V1227930 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_592678 V1227934 ABGT H Transporter COG2978 Cluster_592679 V1227935 S NA 0ZHU9 Cluster_836169 V1227938 YNAI M mechanosensitive ion channel COG0668 Cluster_596128 V1227939 CMTA S Trehalose corynomycolyl transferase COG0627 Cluster_592680 V1227940 map03440 K Transcriptional regulator COG2865 Cluster_592681 V1227941 L Replication initiation and membrane attachment COG3935 Cluster_592682 V1227942 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_714999 V1227945 RAMB K transcriptional regulator COG3800 Cluster_596130 V1227946 CCSB O Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) COG1333 Cluster_592684 V1227948 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_596131 V1227950 GABD2 map00010,map00040,map00053,map00071,map00250,map00280,map00310,map00330,map00340,map00350,map00360,map00380,map00410,map00561,map00620,map00625,map00640,map00643,map00650,map00903,map01100,map01110,map01120 C Dehydrogenase COG1012 Cluster_755005 V1227953 C Nitroreductase COG0778 Cluster_592685 V1227954 S NA 11SJ2 Cluster_766257 V1227956 HMUT map02010 P Periplasmic binding protein COG0614 Cluster_596132 V1227958 HRPA L ATP-dependent helicase COG1643 Cluster_596133 V1227959 L integrase family 0XRS7 Cluster_632899 V1227962 V restriction modification system DNA specificity domain COG0732 Cluster_596135 V1227963 S NA 0ZX6K Cluster_596136 V1227964 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_661309 V1227965 map00030,map01100,map01110,map01120 G Shikimate kinase COG3265 Cluster_669789 V1227966 ARTM2 E amino acid AbC transporter COG0765 Cluster_592687 V1227975 DXS map00730,map00900,map01100,map01110 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) COG1154 Cluster_925451 V1227977 RPLT map03010 J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) COG0292 Cluster_809175 V1227979 YBGL E lamb ycsf family protein COG1540 Cluster_592688 V1227980 DCUC C C4-dicarboxylate transporter COG3069 Cluster_640958 V1227981 S X-X-X-Leu-X-X-Gly heptad repeats COG1511 Cluster_596140 V1227988 S Membrane COG0392 Cluster_596141 V1227989 S Membrane COG2149 Cluster_734711 V1227990 S Membrane 12317 Cluster_596142 V1227991 SCLAV_0509 S Cytochrome c oxidase caa3-type, assembly factor ctag-related protein COG3336 Cluster_596143 V1227992 COBN map00860,map01100 H cobaltochelatase, cobn subunit COG1429 Cluster_596145 V1227995 FTSX map02010 D Part of the ABC transporter FtsEX involved in cellular division (By similarity) COG2177 Cluster_596146 V1227996 UVRA map03420 L Excinuclease abc subunit a COG0178 Cluster_596147 V1227997 LMRS P Transporter 0ZVUY Cluster_596149 V1227999 SDHC map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120 C succinate dehydrogenase 11IIM Cluster_596151 V1228001 V Type I restriction modification DNA specificity domain 11G07 Cluster_596152 V1228004 M Glycosyl transferase, family 2 COG0463 Cluster_596153 V1228006 Q Putative Ig domain 0ZUG3 Cluster_695938 V1228007 CYSG map00860,map01100,map01110 H Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) COG0007 Cluster_596154 V1228008 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_748126 V1228009 L Excisionase 0YY4J Cluster_596155 V1228012 HUTG map00330,map00340,map01100 E formiminoglutamate hydrolase COG0010 Cluster_824733 V1228015 THYX map00240,map00670 F Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) COG1351 Cluster_820748 V1228016 NADE map00760,map01100 H Nad synthetase COG0388 Cluster_596157 V1228018 V Mate efflux family protein COG0534 Cluster_596159 V1228020 S phage Major head protein 11QR8 Cluster_599638 V1228021 S ABC transporter (Permease COG1079 Cluster_596160 V1228022 S Inherit from NOG: Bacterial group 2 Ig-like protein 0ZJ6A Cluster_599639 V1228023 SPSC map00362,map00363,map00520,map00626,map00650,map00903,map01100,map01110,map01120,map02020 M Polysaccharide biosynthesis protein COG0399 Cluster_773673 V1228024 DAPF map00300,map01100,map01110,map01120,map01230 E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) COG0253 Cluster_661310 V1228025 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_805135 V1228027 EXPZ S ABC transporter COG0488 Cluster_687599 V1228028 GATA map00970,map01100 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) COG0154 Cluster_648885 V1228029 CTAB map00190,map00860,map01100,map01110 O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) COG0109 Cluster_762294 V1228030 S Membrane 11K10 Cluster_596161 V1228032 SMVA G major facilitator superfamily COG0477 Cluster_859580 V1228035 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_599640 V1228038 S NA 129E3 Cluster_695939 V1228039 GLUD map00250,map00330,map00430,map00471,map00910,map01100,map04964 E Glutamate dehydrogenase COG0334 Cluster_636934 V1228041 G Glycoside Hydrolase Family 25 126DR Cluster_599641 V1228042 PHON map00627,map00740,map01120,map02020 I Phosphoesterase, PA-phosphatase related COG0671 Cluster_596164 V1228043 I CoA-substrate-specific enzyme activase COG1924 Cluster_599642 V1228044 SP_0913 V ABC transporter (Permease COG0577 Cluster_599643 V1228045 ILVA map00260,map00290,map01100,map01110,map01230 E threonine COG1171 Cluster_599645 V1228047 S Rib/alpha-like repeat 10008 Cluster_828556 V1228050 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_728193 V1228054 S NA 0XT1M Cluster_596165 V1228055 TRKH P Potassium uptake protein COG0168 Cluster_599647 V1228056 CMP M Major outer membrane protein 17MV0@proNOG Cluster_599648 V1228060 SUHB map00521,map00562,map01100,map01110,map04070 G inositol monophosphatase COG0483 Cluster_599649 V1228062 MT3751 L Helicase COG1205 Cluster_683165 V1228064 YWQN S fmn reductase COG0655 Cluster_614143 V1228067 ILVD map00290,map00770,map01100,map01110,map01210,map01230 E Dihydroxy-acid dehydratase COG0129 Cluster_599651 V1228068 RPLU map03010 J This protein binds to 23S rRNA in the presence of protein L20 (By similarity) COG0261 Cluster_599652 V1228069 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_599653 V1228070 TRKH P Potassium uptake protein COG0168 Cluster_657083 V1228071 RECX S Modulates RecA activity (By similarity) 0ZJ58 Cluster_724916 V1228072 AZL_008490 L DNA methylase COG0863 Cluster_599654 V1228075 MUTS2 L DNA mismatch repair protein COG0249 Cluster_599655 V1228078 S Zinc finger, swim domain protein 0YH4C Cluster_599656 V1228079 TRAG map03070 U TraG TraD family protein COG3505 Cluster_599657 V1228080 SCLAV_0509 S Cytochrome c oxidase caa3-type, assembly factor ctag-related protein COG3336 Cluster_599658 V1228081 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_599660 V1228083 DESPR_0185 S Phage gene transfer protein 17JCZ@proNOG Cluster_599661 V1228084 DNAG map03030 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 Cluster_599663 V1228086 CTPE P ATPase, P-type (Transporting), HAD superfamily, subfamily IC COG0474 Cluster_599664 V1228087 S domain protein COG3428 Cluster_599665 V1228088 map00020,map00310,map00380,map01100,map01110,map01120 C 2-oxoglutarate dehydrogenase, E1 subunit COG0567 Cluster_748127 V1228090 HASR P Receptor 16RPG@proNOG Cluster_599667 V1228092 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_744779 V1228094 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_603209 V1228095 U Type iv secretory pathway vird4 0XSWX Cluster_599668 V1228098 TRKH P Potassium uptake protein COG0168 Cluster_599669 V1228099 ACEE map00010,map00020,map00620,map00650,map01100,map01110,map01120 C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) COG2609 Cluster_708485 V1228102 NRTD map00910,map02010 P (ABC) transporter COG1116 Cluster_599670 V1228104 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_603210 V1228106 SP_0319 G isomerase COG0698 Cluster_599671 V1228107 ASPA map00250,map00910,map01100 E Aspartate ammonia-lyase COG1027 Cluster_621575 V1228108 PNTB map00760,map01100 C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) COG1282 Cluster_603211 V1228111 ARC map03050 O ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) COG0464 Cluster_599672 V1228112 S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) COG4950 Cluster_599673 V1228114 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_758528 V1228115 S Membrane 0Y0H4 Cluster_748128 V1228117 TRPP S Membrane COG5658 Cluster_599674 V1228118 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_603212 V1228119 EBA2484 L AtP-binding protein COG1484 Cluster_699221 V1228121 S Protein of unknown function (DUF2516) 0XXPZ Cluster_599675 V1228122 map02010 P periplasmic COG0803 Cluster_603214 V1228124 HSDM V N-6 DNA Methylase COG0286 Cluster_599676 V1228125 YYCI S YycI protein COG4853 Cluster_603215 V1228126 PIMA M Glycosyl transferase (Group 1 COG0438 Cluster_603216 V1228127 FRUK map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G 1-phosphofructokinase COG1105 Cluster_715001 V1228128 TRKA P domain protein COG0569 Cluster_599677 V1228129 HMP map05132 C nitric oxide dioxygenase (EC 1.14.12.17) COG1018 Cluster_599678 V1228130 NUC L nuclease COG1525 Cluster_851793 V1228133 L transposase, IS3 IS911 family protein COG2963 Cluster_603217 V1228134 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_603219 V1228136 MNHG P monovalent cation H antiporter subunit G COG1320 Cluster_603220 V1228138 PGM map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_603221 V1228140 RPSD map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) COG0522 Cluster_900614 V1228141 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_603222 V1228142 S NA 0Z9AC Cluster_603223 V1228143 PAAB map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120 I Enoyl-CoA hydratase COG1024 Cluster_603224 V1228144 SP_0341 S UPF0371 protein COG4868 Cluster_603225 V1228145 HEMD map00860,map01100,map01110 H synthase COG1587 Cluster_603226 V1228146 P transporter COG0471 Cluster_603227 V1228147 S Phenazine biosynthesis-like protein COG0384 Cluster_603229 V1228150 RV0561C map00860,map00900,map01100,map01110 C geranylgeranyl reductase COG0644 Cluster_758529 V1228151 YYBS S Membrane COG4241 Cluster_603230 V1228153 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_603231 V1228154 PURN map00230,map00670,map01100,map01110 F phosphoribosylglycinamide formyltransferase COG0299 Cluster_603232 V1228155 S Inherit from COG: oxidoreductase 0XPNK Cluster_603233 V1228156 map05132 M repeat protein COG3209 Cluster_603234 V1228157 LPQB S lipoprotein lpqb 0ZF99 Cluster_603235 V1228159 RHLE map03018 L atp-dependent rna helicase COG0513 Cluster_603236 V1228160 map00040,map01100 G dehydratase COG2721 Cluster_674195 V1228161 PGSA map00564,map01100 I cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase COG0558 Cluster_603237 V1228162 OPPF map02010 E, P ABC transporter COG1123 Cluster_766258 V1228165 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_603239 V1228166 S NA 11HU2 Cluster_610484 V1228168 THIH map00730,map01100 H biosynthesis protein thiH COG1060 Cluster_603240 V1228169 MRPA map00190 P monovalent cation H antiporter subunit A COG2111 Cluster_603241 V1228170 S NA 0Z55Q Cluster_603242 V1228171 S NA 1241G Cluster_800939 V1228174 NRDF map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_603243 V1228175 O Secreted protein COG1651 Cluster_603244 V1228176 S NA 11V4N Cluster_603245 V1228177 map03022,map03420 L type iii restriction protein res subunit COG1061 Cluster_678631 V1228180 I Acyltransferase family COG1835 Cluster_606822 V1228181 P ABC transporter COG1116 Cluster_705389 V1228182 S NA 0YIEB Cluster_603247 V1228183 D ftsk SpoIIIE family protein COG1674 Cluster_603248 V1228184 MOAB2 H molybdenum cofactor biosynthesis protein COG0521 Cluster_603249 V1228187 M Glycosyl transferase (Group 1 11FP0 Cluster_669790 V1228188 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG0469 Cluster_606823 V1228191 MACB2 V Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) COG1136 Cluster_606825 V1228195 GCVP map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG1003 Cluster_751549 V1228198 G Transporter 0XP7I Cluster_603251 V1228199 HALSA_0062 M Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase COG2148 Cluster_606826 V1228200 S NA 101UU Cluster_606827 V1228202 UVRD2 map03420,map03430 L helicase COG2887 Cluster_603252 V1228204 S NA 0YBR5 Cluster_606828 V1228205 LIPS2 map00561,map01100 S Secretory lipase 0YTM1 Cluster_603253 V1228209 MT1099 S Membrane COG4425 Cluster_606830 V1228210 WAAB map00540,map01100 M Glycosyltransferase COG0438 Cluster_606831 V1228211 YHJD S ribonuclease COG1295 Cluster_606832 V1228213 GLGA map00500,map01100,map01110,map04973 G Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) COG0297 Cluster_606833 V1228214 CMEC M RND efflux system, outer membrane lipoprotein COG1538 Cluster_741475 V1228216 YHAN S domain protein COG4717 Cluster_665483 V1228217 HIGA S Plasmid maintenance system antidote protein COG3093 Cluster_606834 V1228218 S NA 125VG Cluster_603255 V1228219 YQFA S UPF0365 protein COG4864 Cluster_606836 V1228221 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_606837 V1228222 S polysaccharide biosynthesis protein 0XVEX Cluster_603256 V1228223 TGT J Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COG0343 Cluster_606838 V1228225 YNAI M mechanosensitive ion channel COG0668 Cluster_606839 V1228226 VANK G major facilitator superfamily COG0477 Cluster_674196 V1228227 map00350,map00362,map00627,map00642,map00903,map01120 I acyltransferase 3 COG1835 Cluster_606840 V1228228 NORB map00910,map01120 P Nitric oxide reductase COG3256 Cluster_606841 V1228232 ARGR K Regulates arginine biosynthesis genes (By similarity) COG1438 Cluster_695940 V1228233 SCPA S Segregation and condensation protein COG1354 Cluster_606842 V1228235 BMUL_5818 C Iron-sulfur cluster binding protein COG1139 Cluster_724917 V1228237 S NA 11NM2 Cluster_816937 V1228238 map00230,map00270,map00760,map01100 F nucleosidase COG0775 Cluster_606845 V1228241 DCTP C symporter COG1301 Cluster_751551 V1228243 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_606847 V1228247 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_606848 V1228248 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_606849 V1228251 map03410,map03420,map03430,map03450 L DNA polymerase LigD, ligase COG1793 Cluster_606851 V1228253 EMBC M Arabinosyltransferase 0XSQE Cluster_809176 V1228254 RPLW map03010 J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) COG0089 Cluster_855573 V1228255 RPLD map03010 J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) COG0088 Cluster_606852 V1228256 S NA 11H5V Cluster_606853 V1228257 L transposase 11GFI Cluster_606854 V1228258 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_606855 V1228259 LEUB map00290,map01100,map01110,map01210,map01230 E Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) COG0473 Cluster_669791 V1228260 SSCG_02866 map02010 V abc transporter COG1132 Cluster_606856 V1228261 map00511,map04142 G beta-mannosidase EC 3.2.1.25 COG3250 Cluster_644817 V1228262 GPMB map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_781130 V1228263 RNPA J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) 124YT Cluster_606857 V1228264 YDIU S UPF0061 protein COG0397 Cluster_824735 V1228265 GLPP K glycerol-3-phosphate responsive antiterminator COG1954 Cluster_820749 V1228268 ALST E amino acid carrier protein COG1115 Cluster_610485 V1228269 V Inherit from COG: Type I site-specific deoxyribonuclease COG0610 Cluster_610486 V1228270 VIRE2 S Virulence-associated protein e COG5545 Cluster_606858 V1228272 IDSA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_652956 V1228273 L dna methyltransferase 0XP2S Cluster_606860 V1228275 YFDZ map00300,map01100,map01110,map01230 E Aspartate aminotransferase COG0436 Cluster_606861 V1228277 CHUA P Receptor COG1629 Cluster_728194 V1228278 YOCR P Transporter COG0733 Cluster_669792 V1228279 RBSB map02010,map02030 G Ribose ABC transporter COG1879 Cluster_610487 V1228280 RECG map03420,map03440 L transcriptioN-repair coupling factor COG1197 Cluster_718247 V1228282 EXBB2 U MotA TolQ exbB proton channel COG0811 Cluster_610488 V1228284 NARB map00630,map00680,map00910,map01100,map01120 C Molydopterin dinucleotide binding domain COG0243 Cluster_606863 V1228286 D Chromosome segregation protein SMC COG1196 Cluster_606864 V1228287 ADHC map00010,map00561,map00930,map01100,map01110,map01120 C alcohol dehydrogenase COG1064 Cluster_610489 V1228288 L DNA polymerase 0XRUF Cluster_610491 V1228290 PCCB map00280,map00630,map00640,map00720,map01100,map01120 I carboxyl transferase COG4799 Cluster_606865 V1228291 S Amidohydrolase COG3618 Cluster_863918 V1228292 RPIB map00030,map00710,map01100,map01110,map01120,map01230 G Ribose/Galactose Isomerase COG0698 Cluster_606866 V1228293 FPRA map00250,map00910,map01100,map01110,map01120,map01230 C reductase COG0493 Cluster_610492 V1228294 VIOA map00362,map00363,map00626,map00650,map00903,map01100,map01110,map01120 E DegT DnrJ EryC1 StrS COG0399 Cluster_606867 V1228295 M Glycosyl transferase, family 2 COG0463 Cluster_636935 V1228296 LICT K antiterminator COG3711 Cluster_606869 V1228299 P TonB-dependent Receptor Plug Domain 0YD5U Cluster_606870 V1228300 COMEC S ComEC rec2-like protein COG0658 Cluster_657084 V1228301 GLNQ map02010 E ABC transporter, ATP-binding protein COG1126 Cluster_606871 V1228303 NHAP P Na H antiporter COG0025 Cluster_606872 V1228304 UVRD2 map03420,map03430 L helicase COG2887 Cluster_606873 V1228305 ADHC map00010,map00561,map00930,map01100,map01110,map01120 C alcohol dehydrogenase COG1064 Cluster_610495 V1228306 DCUB map02020 O Anaerobic c4-dicarboxylate transporter COG2704 Cluster_610496 V1228307 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_629074 V1228308 FOLA map00670,map00790,map01100 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) COG0262 Cluster_610497 V1228310 Q Nonribosomal peptide synthase COG1020 Cluster_606874 V1228311 GOR map00480 C reductase COG1249 Cluster_606875 V1228312 AMAA map00360 E amidohydrolase COG1473 Cluster_610498 V1228313 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_610499 V1228314 COAX map00770,map01100 K Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) COG1521 Cluster_610501 V1228317 S NA 0ZV0P Cluster_606876 V1228321 CASA L crispr-associated protein 0XPA1 Cluster_606877 V1228323 LPQC Q polyhydroxybutyrate depolymerase COG3509 Cluster_769989 V1228325 S Protein of unknown function (DUF2089) COG3877 Cluster_773675 V1228326 GLPX map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120 G Fructose-1,6-bisphosphatase COG1494 Cluster_610503 V1228327 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_610505 V1228329 NHAC C Na H antiporter COG1757 Cluster_610506 V1228330 L transposase IS605 OrfB family 0XT7Q Cluster_610507 V1228331 UDK map00240,map00983,map01100 F uridine monophosphokinase COG0572 Cluster_610508 V1228332 PGLF M epimerase dehydratase COG1086 Cluster_610509 V1228333 map00230,map00240,map00760,map01100,map01110 F 5'-nucleotidase COG2374 Cluster_610510 V1228334 map00061,map01100 I carbamoyL-phosphate synthase l chain ATP-binding COG4770 Cluster_610511 V1228335 COBW S cobalamin synthesis protein COG0523 Cluster_610512 V1228336 MTSC map02010,map02020 P ABC transporter COG1108 Cluster_610514 V1228338 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_610515 V1228339 S esterase 1294K Cluster_610516 V1228340 S Phage infection protein COG1511 Cluster_610518 V1228342 S Uncharacterized protein conserved in bacteria (DUF2236) COG3662 Cluster_610519 V1228343 IUNH2 map00230,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_610521 V1228345 map02010 E, T ABC transporter substrate-binding protein COG0834 Cluster_621576 V1228347 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_610522 V1228348 ILVA map00260,map00290,map01100,map01110,map01230 E Threonine dehydratase COG1171 Cluster_610523 V1228350 GLNA4 map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG0174 Cluster_610524 V1228353 S NA 0ZHU9 Cluster_785260 V1228354 YKOE S ABC superfamily ATP binding cassette transporter membrane protein COG4721 Cluster_614144 V1228355 S Abortive infection protein COG1266 Cluster_614145 V1228356 U, W surface protein COG5295 Cluster_610525 V1228357 IRP6A map02010 P Periplasmic binding protein COG0614 Cluster_711621 V1228358 S similarity to GP 11230710 0YRAJ Cluster_777390 V1228364 TRPA map00260,map00400,map01100,map01110,map01230 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) COG0159 Cluster_610527 V1228365 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_610528 V1228367 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_738057 V1228368 LPXB map00540,map01100 M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) COG0763 Cluster_610529 V1228370 P TonB-dependent receptor Plug 0XNPQ Cluster_610530 V1228371 P drug resistance transporter, EmrB QacA subfamily 0XNN3 Cluster_610531 V1228372 P Sodium/hydrogen exchanger family COG0025 Cluster_614148 V1228373 S domain protein 11ZQG Cluster_610532 V1228374 RPE map00030,map00040,map00710,map01100,map01110,map01120,map01230 G ribulose-phosphate 3-epimerase COG0036 Cluster_741476 V1228375 U, W Inherit from COG: domain protein COG5295 Cluster_614150 V1228379 S NA 12B83 Cluster_614152 V1228381 SP_0496 P Na Pi-cotransporter COG1283 Cluster_610534 V1228382 PDTAS T Histidine kinase COG3920 Cluster_879993 V1228383 NADA map00760,map01100 H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) COG0379 Cluster_678632 V1228384 SMVA G major facilitator superfamily COG0477 Cluster_614153 V1228385 HSDM V HsdM N-terminal domain COG0286 Cluster_614154 V1228386 G Drug resistance transporter EmrB QacA 0XNN3 Cluster_614156 V1228389 S CAAX amino terminal protease family protein COG1266 Cluster_614157 V1228390 ECTP P Transporter COG1292 Cluster_614158 V1228393 K LysR family Transcriptional regulator 0YPRW Cluster_614160 V1228396 V type II restriction enzyme, methylase subunit COG1002 Cluster_610535 V1228397 YOJN S ATPase associated with various cellular activities aaa_5 COG0714 Cluster_762297 V1228400 L dEAD DEAH box helicase COG1204 Cluster_610536 V1228401 ILVD map00290,map00770,map01100,map01110,map01210,map01230 E Dihydroxy-acid dehydratase COG0129 Cluster_614161 V1228402 S NA 11FGU Cluster_610537 V1228404 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_614162 V1228405 M Cna protein B-type domain 0ZN11 Cluster_610538 V1228406 S Inherit from COG: Fusaric acid resistance protein COG1289 Cluster_614163 V1228407 SCRA map00500,map02060 G phosphotransferase system, EIIB COG1264 Cluster_614164 V1228408 DNAE2 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase (By similarity) COG0587 Cluster_614165 V1228409 CMK map00240,map00410,map00770,map01100,map01110 F Cytidine monophosphate kinase COG0283 Cluster_614166 V1228411 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_652957 V1228412 MT2477 S PemK-like protein 11VAX Cluster_614167 V1228413 LPPS S ErfK ybiS ycfS ynhG family protein COG1376 Cluster_614169 V1228415 S Relaxase mobilization nuclease 0ZY81 Cluster_614170 V1228416 GND map00030,map00480,map01100,map01110,map01120 G 6-phosphogluconate dehydrogenase COG1023 Cluster_614171 V1228417 MOAA map00790,map01100,map04122 H Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) COG2896 Cluster_614174 V1228421 S NA 0XPJ6 Cluster_614175 V1228422 S integral membrane protein 11P1U Cluster_614176 V1228425 LCD map00270,map00450,map00920,map01100,map01110,map01230 E Aminotransferase class I and II COG1168 Cluster_614177 V1228427 TYRA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydrogenase COG0287 Cluster_614178 V1228429 S NA 0XQ6D Cluster_614179 V1228430 NADE map00760,map01100 H Nad synthetase COG0388 Cluster_614180 V1228431 FAS map00061,map00350,map00362,map00627,map00642,map00903,map01100,map01120 I synthase COG4982 Cluster_617900 V1228436 map00550,map01100 M glycosyl transferase, family 51 COG0744 Cluster_614181 V1228438 map00260,map01100 E sarcosine oxidase (alpha subunit) COG0446 Cluster_617902 V1228440 HISD map00340,map01100,map01110,map01230 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) COG0141 Cluster_617903 V1228441 UVRD2 map03420,map03430 L helicase COG2887 Cluster_738058 V1228444 AROP E amino acid COG1113 Cluster_617905 V1228446 PLSC map00561,map00564,map01100 I Acyl-transferase 0Z3QU Cluster_614183 V1228449 S Membrane COG0730 Cluster_614184 V1228450 FEPD map02010 P transport system permease protein COG0609 Cluster_614185 V1228451 IRP3 map01053 Q Thiazolinyl imide reductase COG4693 Cluster_614186 V1228452 LMRD V ABC transporter COG1132 Cluster_614187 V1228453 ELI_1297 O phage portal protein HK97 family COG4695 Cluster_614188 V1228454 VIRD4 map03070 U TraG TraD family protein COG3505 Cluster_614189 V1228455 ARTH_4141 map00620 C d-lactate dehydrogenase COG0277 Cluster_728195 V1228458 S CobW_C COG0523 Cluster_617908 V1228460 MALH map00010,map00500 G glycoside hydrolase family 4 COG1486 Cluster_617909 V1228463 S NA 101UU Cluster_617910 V1228464 SIGD K RNA Polymerase 10PD0 Cluster_614192 V1228465 DPNA L helicase COG4646 Cluster_617911 V1228467 S NA 0ZHU9 Cluster_617912 V1228469 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_621577 V1228470 S NA 0YBW6 Cluster_820751 V1228472 ACEE map00010,map00020,map00620,map00650,map01100,map01110,map01120 C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) COG2609 Cluster_617914 V1228476 SCPA S Segregation and condensation protein COG1354 Cluster_617915 V1228478 S Rib/alpha-like repeat 10008 Cluster_617917 V1228480 ASPA map00250,map00910,map01100 E Aspartate ammonia-lyase COG1027 Cluster_614194 V1228481 ACEB map00620,map00630,map01100,map01120 C Malate synthase COG2225 Cluster_617919 V1228483 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_617920 V1228484 OPCA G OpcA protein COG3429 Cluster_617921 V1228486 L nudix hydrolase COG0494 Cluster_617922 V1228487 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_617923 V1228489 RSEP map04112 M Membrane-associated zinc metalloprotease COG0750 Cluster_617924 V1228490 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_683166 V1228491 PFLA O Pyruvate formate-lyase COG1882 Cluster_617925 V1228493 PEPQ map00310,map00780,map01100 E peptidase M24 COG0006 Cluster_617926 V1228494 MT2770 S Protein of unknown function (DUF3710) 11Q1S Cluster_617927 V1228495 M 2 glycosyl transferase COG0463 Cluster_617928 V1228496 GAPA map00010,map01100,map01110,map01120,map01230,map04066,map05010 G Glyceraldehyde-3-phosphate dehydrogenase, type I COG0057 Cluster_617929 V1228497 ACX map00071,map00592,map01040,map01100,map03320,map04146 I acyl-CoA oxidase COG1960 Cluster_617930 V1228499 G Glycoside hydrolase family 76 COG4833 Cluster_617931 V1228500 S Inherit from NOG: Tail protein COG5412 Cluster_617934 V1228504 MT2802 S atpase involved in dna repair 0XNTH Cluster_824736 V1228506 HUPH S HupH hydrogenase expression protein 0ZXA4 Cluster_773676 V1228508 DTD J Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) COG1490 Cluster_702294 V1228509 THID map00730,map01100 H phosphomethylpyrimidine kinase COG0351 Cluster_617935 V1228510 TETB map02010 V ABC transporter COG1132 Cluster_617936 V1228512 S Filamentation induced by cAMP protein fic COG3177 Cluster_777392 V1228515 PEPP map00310,map00780,map01100 E peptidase M24 COG0006 Cluster_692126 V1228516 MT2802 S atpase involved in dna repair 0XNTH Cluster_617938 V1228517 SCLAV_3115 O DSBA oxidoreductase COG1651 Cluster_617939 V1228518 BOPA E Extracellular solute-binding protein, family 5 COG0747 Cluster_621578 V1228520 GCVP map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG1003 Cluster_617940 V1228521 YHJD S ribonuclease COG1295 Cluster_621579 V1228522 SBCD L exonuclease COG0420 Cluster_805138 V1228525 FNT P nitrite transporter COG2116 Cluster_785261 V1228527 RGPD map02010 P ABC transporter, ATP-binding protein COG1134 Cluster_921504 V1228528 RGPD map02010 P ABC transporter, ATP-binding protein COG1134 Cluster_715003 V1228530 FATD map02010 P permease protein COG4606 Cluster_617941 V1228531 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0847 Cluster_617942 V1228532 U, W Pfam:YadA COG5295 Cluster_781131 V1228534 SCLAV_3420 map02010,map02020 V abc transporter COG1131 Cluster_636936 V1228535 S Protein of unknown function (DUF1470) 126ZZ Cluster_721571 V1228538 M Export protein 11MRX Cluster_617945 V1228540 NOSZ map00910,map01120 C Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide (By similarity) COG4263 Cluster_711623 V1228541 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_617946 V1228543 TRSE U traE protein COG3451 Cluster_813162 V1228544 L Transposase, Mutator family COG3328 Cluster_621583 V1228546 S NA 0YGJM Cluster_621584 V1228548 METX map00270,map00920,map01100 E Homoserine O-trans-acetylase COG2021 Cluster_617947 V1228549 S NA 0ZHVH Cluster_617948 V1228550 C Binding Domain protein 11NY9 Cluster_734713 V1228551 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit epsilon COG0847 Cluster_824737 V1228557 RV0049 S NA 11WJF Cluster_851796 V1228558 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_751552 V1228560 O peptidylprolyl cis-trans isomerase COG0545 Cluster_621587 V1228562 POXB map00620,map01100 C pyruvate dehydrogenase COG0028 Cluster_621588 V1228565 MGTE P magnesium transporter COG2239 Cluster_621589 V1228566 AGCS map02020 E amino acid carrier protein COG1115 Cluster_617951 V1228567 OCAR_6752 H DNA integration recombination invertion protein COG1636 Cluster_621591 V1228570 S structural protein 11RQ6 Cluster_661311 V1228571 SCLAV_4612 D Chromosome partitioning ATPase COG0455 Cluster_621592 V1228572 DCTP C symporter COG1301 Cluster_621593 V1228573 E, G EamA-like transporter family COG0697 Cluster_621594 V1228574 G ROK family COG1940 Cluster_621595 V1228575 PYRC map00240,map01100 F dihydroorotase COG0044 Cluster_621596 V1228576 HEMD map00860,map01100,map01110 H synthase 0ZMK2 Cluster_621597 V1228577 S Membrane COG3949 Cluster_621598 V1228578 map00051 M glycosyl transferase group 1 10G3K Cluster_621599 V1228579 YCGV M, U Autotransporter COG3468 Cluster_621600 V1228583 S alpha-2-macroglobulin COG2373 Cluster_621601 V1228584 HRPB L ATP-dependent helicase COG1643 Cluster_625354 V1228585 FOLK map00790,map01100 H 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase COG0801 Cluster_728196 V1228586 S MarR family Transcriptional regulator COG3189 Cluster_621602 V1228587 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_621604 V1228592 I NADP oxidoreductase coenzyme F420-dependent COG2084 Cluster_621605 V1228593 S Pfam:DUF88 10WX0 Cluster_625356 V1228594 Q depolymerase COG3509 Cluster_621606 V1228595 PURB2 map00230,map00250,map00362,map01100,map01110,map01120 F 3-carboxy-cis-cis-muconate cycloisomerase COG0015 Cluster_769991 V1228597 LEUC map00290,map00300,map00660,map01100,map01110,map01210,map01230 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) COG0065 Cluster_621607 V1228598 SCLAV_4848 S Protein of unknown function (DUF3000) 11PF6 Cluster_621608 V1228599 CAFA map03018 J ribonuclease COG1530 Cluster_621610 V1228601 MT3294 P TrkA-N domain protein COG1226 Cluster_652958 V1228602 S NA 0ZHU9 Cluster_820752 V1228606 INV1 M NLP P60 protein COG0791 Cluster_629075 V1228607 MQNC-2 H radical SAM domain protein COG1060 Cluster_625358 V1228609 S YhgE Pip N-terminal domain protein COG1511 Cluster_625360 V1228613 S ragb susd domaiN-containing protein 0XVY3 Cluster_621613 V1228614 GLNR K Transcriptional regulator COG0789 Cluster_652959 V1228615 MT1099 S Membrane COG4425 Cluster_678633 V1228617 S NA 0YAIS Cluster_621614 V1228618 SECD map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) COG0342 Cluster_738062 V1228621 ISPF map00900,map01100,map01110 I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) COG0245 Cluster_621615 V1228622 KDPB map02020 P One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) COG2216 Cluster_621616 V1228624 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_625363 V1228626 UVRD2 map03420,map03430 L helicase COG2887 Cluster_820753 V1228627 S NA 1258Z Cluster_625364 V1228628 MTNK map00270,map01100 S Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) COG4857 Cluster_621617 V1228629 JAG S Single-stranded nucleic acid binding R3H domain-containing protein COG1847 Cluster_625365 V1228631 ENTE map01053 Q 2,3-dihydroxybenzoate-AMP ligase COG1021 Cluster_661312 V1228632 MURD map00471,map00550,map01100 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COG0771 Cluster_687600 V1228633 S NA 0ZYRK Cluster_695943 V1228634 SCLAV_4353 T Histidine kinase 11H4Z Cluster_625366 V1228636 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_728197 V1228637 TRXA O Thioredoxin COG0526 Cluster_625367 V1228639 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_625369 V1228641 P peroxidase COG2837 Cluster_879996 V1228642 map04112 M POTRA domain, FtsQ-type 124MD Cluster_621618 V1228644 SCLAV_2562 L nudix hydrolase COG0494 Cluster_793057 V1228646 map00240,map00250,map01100 E, F Carbamoyl phosphate synthase-like protein COG0458 Cluster_625370 V1228648 EXBD1 P biopolymer transport protein ExbD TolR 11Q4N Cluster_625371 V1228649 NPTA P Sodium-dependent phosphate COG1283 Cluster_625372 V1228650 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_625373 V1228651 PKNA T serine threonine protein kinase COG0515 Cluster_625374 V1228653 PPDK map00620,map00680,map00710,map00720,map01100,map01120 G Pyruvate phosphate dikinase COG0574 Cluster_755007 V1228655 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_762299 V1228656 GLGX map00500,map01100,map01110 G Glycogen debranching enzyme COG1523 Cluster_625375 V1228657 HEMN map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_625376 V1228658 YNFM G Major Facilitator Superfamily 0XP8J Cluster_625377 V1228663 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_625378 V1228664 CYNT map00910 P carbonic anhydrase COG0288 Cluster_625379 V1228665 OTSA map00500,map01100 G alpha-alpha-trehalose-phosphate synthase COG1877 Cluster_625380 V1228666 V restriction endonuclease 11VRD Cluster_879998 V1228668 S NA 124TW Cluster_625381 V1228669 S RelA_SpoT COG2357 Cluster_625382 V1228670 S integral membrane protein COG0628 Cluster_625383 V1228672 S NA 0Y0S0 Cluster_629076 V1228674 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_629077 V1228676 AARI_34710 L Transposase for insertion sequence 11IYJ Cluster_744780 V1228678 map00230,map00270,map00760,map01100 F nucleosidase COG0775 Cluster_625384 V1228679 MRPA map00190 P monovalent cation H antiporter subunit A COG2111 Cluster_629078 V1228682 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_724919 V1228683 RDXA C Nitroreductase COG0778 Cluster_625385 V1228685 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_625386 V1228687 ARDC L antirestriction protein COG4227 Cluster_625387 V1228688 GLX_15390 L DNA primase COG0358 Cluster_625388 V1228691 PTSG map00010,map00500,map00520,map02060 G PTS system COG2190 Cluster_744781 V1228693 MENA map00130,map01100,map01110 H 1,4-dihydroxy-2-naphthoate octaprenyltransferase COG1575 Cluster_625390 V1228694 YBGL E lamb ycsf family protein COG1540 Cluster_751553 V1228695 S outer membrane lipoprotein carrier protein 11YKN Cluster_629080 V1228698 MTAD F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) COG0402 Cluster_625391 V1228701 OPCA G OpcA protein COG3429 Cluster_816939 V1228702 PUP O Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) 0ZIK1 Cluster_879999 V1228703 PAFA E Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) 0XPTE Cluster_625392 V1228704 S NA 0Z1A1 Cluster_625393 V1228706 DPPC map02010 P ABC transporter (Permease) COG1173 Cluster_629082 V1228707 map00621,map00624,map00626,map01100,map01120 C, H Monooxygenase COG0654 Cluster_805139 V1228709 PURC map00230,map01100,map01110 F SAICAR synthetase COG0152 Cluster_629083 V1228710 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_640959 V1228713 ALST E amino acid carrier protein COG1115 Cluster_629084 V1228714 MT0945 K Gcn5-related n-acetyltransferase COG0454 Cluster_629085 V1228718 V type I restriction-modification system COG0286 Cluster_699223 V1228720 CAS3 L CRISPR-associated helicase, cas3 COG1203 Cluster_708488 V1228721 V Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) COG1136 Cluster_683167 V1228723 PHAC map00190,map00910,map01100 P Monovalent cation H antiporter subunit C COG1006 Cluster_629087 V1228726 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase ii COG0046 Cluster_683168 V1228729 RPMB map03010 J 50s ribosomal protein l28 COG0227 Cluster_840046 V1228731 GPMB map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_629088 V1228732 PACL2 P ATPase, P-type transporting, HAD superfamily, subfamily IC COG0474 Cluster_748130 V1228733 S DHHA1 domain 0ZEZ4 Cluster_629089 V1228735 Q amino acid adenylation domain protein COG1020 Cluster_632900 V1228737 PPSA map00620,map00680,map00720,map01100,map01120 G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) COG0574 Cluster_687602 V1228738 CG1669 S secreted protein COG2353 Cluster_629090 V1228739 RRGB M Lpxtg-motif cell wall anchor domain protein 0XSEP Cluster_629091 V1228740 T Histidine kinase COG4585 Cluster_629092 V1228742 GLTB map00250,map00630,map00910,map01100,map01110,map01120,map01230 E glutamate synthase COG0070 Cluster_629093 V1228743 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_629094 V1228745 SP_0742 S degv family COG1307 Cluster_629095 V1228746 FADD2 Q Acyl-CoA synthetase COG0318 Cluster_809180 V1228750 PKS13 Q PKS_AT COG3321 Cluster_629096 V1228751 ARTH_4141 map00620 C d-lactate dehydrogenase COG0277 Cluster_629097 V1228752 SCLAV_2087 S Protein of unknown function (DUF2029) 11II4 Cluster_632901 V1228753 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_721572 V1228757 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_629098 V1228759 MURE map00300,map00550 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_629099 V1228760 PACL map04260,map04911,map04960,map04961,map04964,map04970,map04971,map04972,map04973,map04974,map04976,map04978 P ATPase, P-type (transporting), HAD superfamily, subfamily IC COG0474 Cluster_925457 V1228761 CSN1 L crispr-associated protein COG3513 Cluster_629100 V1228764 MSCS M mechanosensitive ion channel COG0668 Cluster_629101 V1228768 C NADH flavin oxidoreductase, NADH oxidase COG1902 Cluster_629102 V1228770 FDHA map00630,map00680,map00720,map01100,map01120 C formate dehydrogenase alpha subunit COG3383 Cluster_629103 V1228771 XDHA map00230,map01100,map01120 C Xanthine dehydrogenase COG1529 Cluster_632902 V1228774 ESTS S sialic acid-specific 9-O-acetylesterase 0XQ2Q Cluster_632903 V1228775 TRPE map00400,map01100,map01110,map01230 E anthranilate synthase component I COG0147 Cluster_629105 V1228776 CSTA T carbon starvation protein COG1966 Cluster_632904 V1228778 SDHA map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020,map05134 C succinate dehydrogenase, flavoprotein subunit COG1053 Cluster_629107 V1228779 GLPX map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120 G Fructose-1,6-bisphosphatase COG1494 Cluster_629108 V1228781 S NA 11YDE Cluster_632905 V1228782 S NA 11TF5 Cluster_632906 V1228783 S NA 11VAR Cluster_640960 V1228787 PEPN map00480,map01100 E Pfam:DUF3358 COG0308 Cluster_699224 V1228788 AROP E amino acid COG1113 Cluster_738063 V1228790 S NA 0Z0H8 Cluster_629109 V1228791 DXR map00900,map01100,map01110 I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) COG0743 Cluster_863923 V1228795 MIHF S integration host factor 11UU9 Cluster_632910 V1228796 GNTP E, G Gluconate COG2610 Cluster_629110 V1228797 L Phage integrase family 0YUUC Cluster_708489 V1228798 S NA 1236P Cluster_840047 V1228799 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_718249 V1228800 S membrane-flanked domain protein COG3402 Cluster_632911 V1228801 MDLA map02010 V ABC transporter COG1132 Cluster_632912 V1228804 U Pfam:GSPII_E COG4962 Cluster_632913 V1228805 FTSK D cell division protein FtsK COG1674 Cluster_632914 V1228807 map02010 P Periplasmic binding protein COG4594 Cluster_632915 V1228808 CMRA S Dehydrogenase COG0300 Cluster_632916 V1228809 PSTA map02010 P phosphate ABC transporter, permease COG0581 Cluster_632917 V1228810 RNY S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 Cluster_708490 V1228811 S NA 11HQF Cluster_632918 V1228812 K Transcriptional regulator, TetR family 0ZW7M Cluster_632919 V1228813 VIBH map01053 Q synthetase COG1020 Cluster_632920 V1228814 AROE map00400,map01100,map01110,map01230 E shikimate COG0169 Cluster_632921 V1228815 S NA 0Z0KZ Cluster_632922 V1228816 S acetyltransferase COG4552 Cluster_632923 V1228817 ACEE map00010,map00020,map00620,map00650,map01100,map01110,map01120 C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) COG2609 Cluster_632925 V1228820 SDAAA map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase COG1760 Cluster_632926 V1228821 NUSA K Transcription elongation factor NusA COG0195 Cluster_632928 V1228825 E Extracellular solute-binding protein, family 5 COG0747 Cluster_632929 V1228826 PTSI map00051,map01100,map02060 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) COG1080 Cluster_636940 V1228828 DPPD map02010 E, P (ABC) transporter COG0444 Cluster_636941 V1228831 P transport protein COG2985 Cluster_636942 V1228834 S glycosyltransferase 0Y8FN Cluster_636944 V1228836 MSCS M mechanosensitive ion channel COG0668 Cluster_632931 V1228838 LICR K TRANSCRIPTIONal COG3711 Cluster_678636 V1228839 NASD map00910,map01120 C nitrite reductase, (NAD(P)H) COG1251 Cluster_632932 V1228840 S NA 11NI8 Cluster_718250 V1228842 RV2616 S Domain of unknown function (DUF1990) COG4762 Cluster_708491 V1228844 YQEK map00760,map01100 H Metal Dependent Phosphohydrolase COG1713 Cluster_632933 V1228845 HRCA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) COG1420 Cluster_851798 V1228847 S NA 0ZA8M Cluster_632935 V1228850 PNCA map00760,map01100 Q nicotinamidase COG1335 Cluster_687603 V1228851 PAFA E Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) 0XPTE Cluster_816941 V1228853 YFEH G Bile acid COG0385 Cluster_632936 V1228855 LLDP C L-lactate COG1620 Cluster_859582 V1228857 PPM1 map00510,map01100 M dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) 0XQRC Cluster_636946 V1228859 IROC map02010 V abc transporter COG1132 Cluster_636947 V1228860 PGM map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_636948 V1228863 M lysozyme COG3757 Cluster_636949 V1228864 PTRB map05142,map05143 E Oligopeptidase b COG1770 Cluster_636950 V1228867 S NA 17SAA@proNOG Cluster_636951 V1228868 G transporter major facilitator family protein 0XRD8 Cluster_636952 V1228869 MSHA M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) COG0438 Cluster_636954 V1228872 AARI_34870 L transposase of ISAar22, IS481 family COG2801 Cluster_875962 V1228873 PTH J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) COG0193 Cluster_636955 V1228874 AROE map00400,map01100,map01110,map01230 E shikimate COG0169 Cluster_636956 V1228875 LHR L helicase COG1201 Cluster_636957 V1228876 S NA 11R2V Cluster_636958 V1228877 OXYR K Transcriptional regulator 0XNR2 Cluster_636959 V1228880 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_900620 V1228881 UDGA map00040,map00053,map00500,map00520,map01100,map01110 M Udp-glucose 6-dehydrogenase COG1004 Cluster_636960 V1228882 HYMB map00190,map00910,map01100 C NADH dehydrogenase COG1894 Cluster_636961 V1228883 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_640961 V1228884 S GtrA-like protein 0YHT4 Cluster_636962 V1228887 L dna polymerase iii delta COG0470 Cluster_636963 V1228888 SSCG_03790 S secreted protein 125I4 Cluster_636964 V1228890 S tail sheath protein COG3497 Cluster_636966 V1228892 MUTS2 map03430 L muts2 protein COG1193 Cluster_636967 V1228893 P periplasmic solute binding protein COG0803 Cluster_636968 V1228894 MQO map00620 C malate dehydrogenase (quinone) COG0579 Cluster_640962 V1228895 CFP6 S low molecular weight protein antigen 6 127P8 Cluster_636969 V1228896 LPPS S ErfK ybiS ycfS ynhG family protein COG1376 Cluster_828559 V1228897 IOLTB G ABC transporter COG1172 Cluster_867923 V1228898 IOLTC G ABC transporter COG1129 Cluster_636970 V1228900 P ABC transporter COG1121 Cluster_657086 V1228901 RGPF M Rhamnan synthesis protein F COG3754 Cluster_636971 V1228902 S hi0933 family COG2081 Cluster_636972 V1228904 AARI_34710 L Transposase for insertion sequence 11IYJ Cluster_636973 V1228905 HISN map00340,map00521,map00562,map01100,map01110,map01230,map04070 E histidinol-phosphate phosphatase COG0483 Cluster_636975 V1228907 SCLAV_4061 S Uncharacterised conserved protein (DUF2342) COG5282 Cluster_652960 V1228912 SCLAV_1731 S Protein of unknown function (DUF3097) 0XR3X Cluster_636977 V1228913 S NA COG4694 Cluster_640964 V1228914 P integral membrane protein COG1253 Cluster_636978 V1228915 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_636979 V1228916 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_721573 V1228917 S Acetyltransferase (GNAT) family 101SE Cluster_640965 V1228919 THIL map00730,map01100 H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) COG0611 Cluster_636980 V1228920 GDHA map00250,map00330,map00910,map01100 E Glutamate dehydrogenase COG0334 Cluster_871860 V1228921 MSRB O reductase COG0229 Cluster_867924 V1228922 YWFI S chlorite dismutase COG3253 Cluster_636981 V1228923 MT1736 S thiamin pyrophosphokinase catalytic COG4825 Cluster_636982 V1228926 GRDA C In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination 11JMA Cluster_769992 V1228927 MT2684 L nudix hydrolase COG0494 Cluster_636983 V1228928 C l-carnitine dehydratase bile acid-inducible protein F COG1804 Cluster_636985 V1228931 P transporter COG0471 Cluster_636986 V1228933 GLPQ map00564 C glycerophosphoryl diester phosphodiesterase COG0584 Cluster_640969 V1228936 L DNA methylase COG2189 Cluster_636987 V1228937 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_917596 V1228938 RPSJ map03010 J Involved in the binding of tRNA to the ribosomes (By similarity) COG0051 Cluster_665487 V1228939 YCFI map02010 V abc transporter COG1132 Cluster_640970 V1228940 ATP2C1 P p-type ATPase COG0474 Cluster_640972 V1228943 CMTB S esterase COG0627 Cluster_836175 V1228944 RNMV L Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) COG1658 Cluster_636989 V1228947 MSHA M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) COG0438 Cluster_692127 V1228949 CIDB map02020 M lrgb family COG1346 Cluster_640974 V1228952 M domain protein COG4932 Cluster_640975 V1228953 MT0536 V Hnh endonuclease 122A9 Cluster_640976 V1228954 TRKH P Potassium uptake protein COG0168 Cluster_636990 V1228955 APPB E, P ABC transporter, permease protein COG0601 Cluster_859584 V1228957 GPMB map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_800940 V1228959 YLBN S metal-binding protein COG1399 Cluster_640977 V1228960 S Pfam:DUF395 COG2391 Cluster_665488 V1228963 HISB map00340,map01100,map01110,map01230 E imidazole-glycerol-phosphate dehydratase COG0131 Cluster_718251 V1228964 S NA 0YYQS Cluster_789260 V1228965 BMUL_5125 S UPF0317 protein COG4336 Cluster_692128 V1228966 TSNR J rrna methyltransferase COG0566 Cluster_721574 V1228967 S (LipO)protein 0YHGC Cluster_734716 V1228970 S Domain of unknown function (DUF1707) 12A7X Cluster_640979 V1228971 PCCB map00280,map00630,map00640,map00720,map01100,map01120 I carboxyl transferase COG4799 Cluster_699225 V1228972 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_640980 V1228973 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01230 G phosphohexose isomerase COG0166 Cluster_718252 V1228974 NUDF map00230 F nudix hydrolase COG0494 Cluster_748132 V1228976 S NA 0YW41 Cluster_699226 V1228978 UGPB map02010 G extracellular solute-binding protein family 1 COG1653 Cluster_640982 V1228979 GLGA map00500,map01100,map01110 G glycogen) synthase COG0438 Cluster_640983 V1228980 YHFE E m42 family COG1363 Cluster_751555 V1228983 BCP O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG1225 Cluster_644821 V1228985 HSDM V Type I restriction-modification system, M subunit COG0286 Cluster_687604 V1228988 RBSK map00030 G ribokinase COG0524 Cluster_640984 V1228992 RV3778C map00730,map04122 E cysteine desulfurase family protein COG0520 Cluster_702296 V1228993 O Tryp_SPc 0YAAN Cluster_683169 V1228995 COAD map00770,map01100 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) COG0669 Cluster_762300 V1228996 THYX map00240,map00670 F Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) COG1351 Cluster_769994 V1228998 RECX S Modulates RecA activity (By similarity) COG2137 Cluster_644823 V1228999 SCLAV_4555 M peptidase COG0739 Cluster_644824 V1229000 PGLB M sugar transferase COG2148 Cluster_644825 V1229001 SDHA map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020,map05134 C succinate dehydrogenase, flavoprotein subunit COG1053 Cluster_683170 V1229004 S ABC transporter, permease COG4120 Cluster_640987 V1229005 CG2284 C uridylyltransferase COG1085 Cluster_644826 V1229008 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_640988 V1229010 S NA 0YEU4 Cluster_644828 V1229013 GND map00030,map00480,map01100,map01110,map01120 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) COG0362 Cluster_644829 V1229017 map00230,map00270,map00760,map01100 F nucleosidase COG0775 Cluster_644830 V1229019 S NA 0Z0R9 Cluster_640989 V1229024 RV1847 Q thioesterase Superfamily protein COG2050 Cluster_644833 V1229028 map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_820754 V1229029 ISPG map00900,map01100,map01110 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) COG0821 Cluster_644834 V1229030 M efflux transporter, rnd family, mfp subunit COG0845 Cluster_644835 V1229031 map00561,map01100 G Dihydroxyacetone kinase COG2376 Cluster_644836 V1229033 CBIK map00860,map01100 H cobalt chelatase COG4822 Cluster_644837 V1229034 ALBF P drug resistance transporter, EmrB QacA subfamily 0XNN3 Cluster_644838 V1229035 ENDA S Prophage Lp1 protein 65 0XSDQ Cluster_644839 V1229036 CG1449 S (LipO)protein 0XRP6 Cluster_731504 V1229037 S VRR-NUC domain protein 122HE Cluster_644840 V1229040 MT3501 L polymerase involved in DNA repair COG0389 Cluster_644841 V1229043 TRPG map00230,map00400,map00790,map00983,map01100,map01110,map01230 E anthranilate synthase COG0512 Cluster_644843 V1229045 S NA 11I0V Cluster_674198 V1229046 MT1287 S NA 11QDU Cluster_644844 V1229047 P tonB-dependent Receptor 0XQ03 Cluster_678637 V1229051 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_644849 V1229055 V Type II restriction 1CAUP@tenNOG Cluster_644850 V1229056 MANA map00051,map00520,map01100,map01110 G mannose-6-phosphate isomerase COG1482 Cluster_644851 V1229057 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_648888 V1229058 DACA map00550,map01100 M d-alanyl-d-alanine carboxypeptidase COG1686 Cluster_644852 V1229059 S NA 11JGF Cluster_644855 V1229063 GCVP map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG1003 Cluster_648889 V1229064 EXPZ S ABC transporter COG0488 Cluster_648890 V1229067 DAGA E amino acid carrier protein COG1115 Cluster_648891 V1229068 MT3769 map00310,map00780,map01100 S secreted protein 11XW7 Cluster_692129 V1229070 TMAR_0884 L Integrase 103Q3 Cluster_644858 V1229072 RV3630 S Membrane 11JY2 Cluster_724923 V1229073 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_797010 V1229074 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_648893 V1229076 S Membrane COG1738 Cluster_648895 V1229080 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0047 Cluster_785262 V1229081 S NA 0Y12I Cluster_734717 V1229082 MUTT3 L nudix hydrolase COG0494 Cluster_648896 V1229083 S NA 11NI8 Cluster_840052 V1229085 MT0398 C oxidoreductase COG0543 Cluster_644859 V1229087 GLDE P CBS domain containing protein COG1253 Cluster_769995 V1229088 M glycosyltransferase group 2 family protein COG3955 Cluster_644860 V1229089 K LysR family Transcriptional regulator 0YPRW Cluster_648897 V1229090 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_644861 V1229091 FAS map00061,map00350,map00362,map00627,map00642,map00903,map01100,map01120 I synthase COG4982 Cluster_884170 V1229093 RV0130 I Dehydratase COG2030 Cluster_708493 V1229096 S Hydrolase 11WY5 Cluster_648898 V1229097 YNFM G Major Facilitator Superfamily 0XP8J Cluster_644863 V1229099 PUTA map00250,map00330,map01100,map01110 C Dehydrogenase COG1012 Cluster_800941 V1229104 G C4-dicarboxylate transport system permease COG1593 Cluster_648902 V1229107 P The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) 0XNUJ Cluster_661314 V1229108 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_648903 V1229109 PQQL O Peptidase, M16 COG0612 Cluster_648904 V1229110 HPPA map00190 C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for COG3808 Cluster_678638 V1229112 S NA 11EJP Cluster_648906 V1229113 map05132 M repeat protein COG3209 Cluster_648907 V1229114 K, L Inherit from COG: helicase COG4646 Cluster_800942 V1229119 SDAAA map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase COG1760 Cluster_648910 V1229121 MSRB O reductase COG0229 Cluster_648911 V1229122 HRRA T regulatoR COG2197 Cluster_648912 V1229124 SCLAV_2829 S Sec-C motif domain protein 100MK Cluster_648913 V1229125 L Phage terminase, large subunit COG1783 Cluster_648914 V1229126 MT3187 M mechanosensitive ion channel COG0668 Cluster_648915 V1229128 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_738066 V1229129 map00360 E amidohydrolase COG1473 Cluster_648916 V1229130 MT1053 D Septum formation initiator family protein COG1507 Cluster_702298 V1229131 RFBC map00521,map00523,map01100,map01110 M Dtdp-4-dehydrorhamnose 3,5-epimerase COG1898 Cluster_648917 V1229132 YXEA map02010 V ABC transporter, permease COG0577 Cluster_648918 V1229133 GLMU map00520,map01100,map01110 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) COG1207 Cluster_648920 V1229136 S membrane protein, AbrB duplication COG3180 Cluster_648922 V1229138 HEPT map00900,map01110 H synthase COG0142 Cluster_652961 V1229139 S CHAP domain 0ZJI2 Cluster_648923 V1229142 DDL map00473,map00520,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_941849 V1229145 S NA 1241G Cluster_648925 V1229146 PURK map00230,map01100,map01110 F phosphoribosylaminoimidazole carboxylase atpase subunit COG0026 Cluster_648926 V1229147 L RecT family 11V51 Cluster_766264 V1229148 RRMA Q Methyltransferase COG0500 Cluster_648927 V1229149 HEML map00860,map01100,map01110 H Glutamate-1-semialdehyde aminotransferase COG0001 Cluster_913253 V1229151 AMN map00230 F Amp nucleosidase COG0775 Cluster_867925 V1229152 S phosphoribosyltransferase 12BNE Cluster_652963 V1229154 DXS map00730,map00900,map01100,map01110 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) COG1154 Cluster_867926 V1229156 S Phage-associated protein 11FS5 Cluster_648929 V1229157 ZUPT P Mediates zinc uptake. May also transport other divalent cations (By similarity) COG0428 Cluster_652965 V1229159 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_652966 V1229160 MT2231 K transcriptional regulatory protein 11UQP Cluster_648930 V1229161 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_859585 V1229166 CCDA O cytochrome C biogenesis COG0785 Cluster_848024 V1229167 CCSX O Redoxin domain protein COG0526 Cluster_648931 V1229170 ILVA map00260,map00290,map01100,map01110,map01230 E Threonine dehydratase COG1171 Cluster_648932 V1229172 V Type I restriction enzyme R protein N terminus (HSDR_N) COG0610 Cluster_648934 V1229174 S Rib/alpha-like repeat 10008 Cluster_652968 V1229175 PKNG map05152 T Serine Threonine protein kinase COG0515 Cluster_678639 V1229176 S NA 11JUD Cluster_648935 V1229178 YGBJ map00051,map00072,map00280,map00363,map00591,map00625,map00630,map00650,map01100,map01120 I Dehydrogenase COG2084 Cluster_789262 V1229179 ALDA map00010,map00040,map00053,map00071,map00280,map00281,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00626,map00640,map00903,map01100,map01110,map01120 C Aldehyde dehydrogenase family COG1012 Cluster_925460 V1229180 GLPP K glycerol-3-phosphate responsive antiterminator COG1954 Cluster_652971 V1229182 MT0425 S secreted protein 10SG5 Cluster_652972 V1229184 HEML map00860,map01100,map01110 H Glutamate-1-semialdehyde aminotransferase COG0001 Cluster_652974 V1229187 SARE_3729 L phage plasmid primase, p4 family COG3378 Cluster_851799 V1229188 SPL M P60 family COG0791 Cluster_777395 V1229190 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_652975 V1229192 Y1855 P asch domain protein COG4405 Cluster_652977 V1229194 S Membrane COG3949 Cluster_652979 V1229196 CSN1 L CRISPR-associated protein, Csn1 family COG3513 Cluster_652980 V1229198 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_652981 V1229199 COMEC S ComEC Rec2-like protein COG0658 Cluster_652983 V1229202 UUP S Abc transporter COG0488 Cluster_652984 V1229203 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii subunits gamma and tau COG2812 Cluster_652985 V1229204 MT0236 S conserved transmembrane protein 0ZV9J Cluster_652990 V1229210 NTPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_781133 V1229213 S Membrane 0XTQ0 Cluster_832280 V1229215 J translation initiation factor if-2 COG0532 Cluster_652993 V1229217 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_652994 V1229218 FTSI map00550 M penicillin-binding protein COG0768 Cluster_652995 V1229219 map00400,map00401,map01100,map01110,map01230 S Prephenate dehydrogenase 0Y96Y Cluster_652996 V1229220 S Tetratricopeptide repeat protein 0XUD3 Cluster_652998 V1229222 RHLE map03018 L atp-dependent rna helicase COG0513 Cluster_657087 V1229223 DCUB map02020 O Anaerobic c4-dicarboxylate transporter COG2704 Cluster_653000 V1229225 SSDA map00250,map00350,map00650,map01100,map01120 C Dehydrogenase COG1012 Cluster_653001 V1229226 map00010,map00500 G glycoside hydrolase family 4 COG1486 Cluster_653002 V1229227 S Protein of unknown function (DUF690) 11F8D Cluster_800943 V1229229 XSEB map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1722 Cluster_687605 V1229230 PCCB map00280,map00630,map00640,map00720,map01100,map01120 I carboxyl transferase COG4799 Cluster_653003 V1229231 S NA 11NJX Cluster_653005 V1229234 ABGT H Transporter COG2978 Cluster_653006 V1229235 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_657088 V1229236 GLNE O, T Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) COG1391 Cluster_653008 V1229242 SDRA V type iii restriction COG1061 Cluster_657092 V1229245 P Membrane COG2836 Cluster_653010 V1229246 PGSA1 map00562,map00564,map01100,map04070 I Cdp-alcohol phosphatidyltransferase COG0558 Cluster_728200 V1229248 YKOE S ABC superfamily ATP binding cassette transporter membrane protein COG4721 Cluster_657095 V1229250 FRUK map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G 1-phosphofructokinase COG1105 Cluster_657096 V1229252 S NA 11NI8 Cluster_653011 V1229253 S NA 11WKP Cluster_657097 V1229254 PAFA1 S proteasome 0XQPS Cluster_653012 V1229255 PCCB map00280,map00630,map00640,map00720,map01100,map01120 I propionyl-CoA carboxylase beta COG4799 Cluster_657098 V1229256 S integral membrane protein COG5522 Cluster_657099 V1229257 PM0594 S Protein of unknown function DUF262 COG1479 Cluster_657100 V1229258 L Inherit from COG: DNA Methylase COG0827 Cluster_657101 V1229259 MCRB V ATPase associated with various cellular activities aaa_5 COG4127 Cluster_657102 V1229260 PBUG S Xanthine uracil vitamin C permease COG2252 Cluster_657103 V1229261 L site-specific recombinase, phage integrase family 0ZF8H Cluster_657104 V1229262 PILT N, U twitching motility protein COG2805 Cluster_657105 V1229263 DNAQ2 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0847 Cluster_657106 V1229264 ARGB map00330,map01100,map01110,map01210,map01230 E nag kinase COG0548 Cluster_657108 V1229268 NIFS map00450,map00730,map01100,map04122 E cysteine desulfurase family protein COG0520 Cluster_657109 V1229269 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_657110 V1229270 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_751556 V1229272 S Ribbon-helix-helix protein, copG family COG4710 Cluster_657111 V1229273 J Glutamine amidotransferase COG2355 Cluster_657112 V1229274 AROK map00400,map01100,map01110,map01230 E Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) COG0703 Cluster_657113 V1229275 GBS0386 S domain protein 0XRRR Cluster_657114 V1229276 V type I restriction-modification system COG0286 Cluster_657116 V1229280 SUFC O feS assembly ATPase SufC COG0396 Cluster_731505 V1229281 META map00270,map00920,map01100,map01110,map01230 E Homoserine O-transsuccinylase COG1897 Cluster_657117 V1229282 L Topoisomerase COG0550 Cluster_678641 V1229284 S NA 0YM53 Cluster_718254 V1229285 MT3693 S secreted protein 11ZB4 Cluster_809181 V1229288 HFLX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COG2262 Cluster_657118 V1229289 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_762301 V1229291 AMAB map00230,map00240,map00410,map00770,map00983,map01100,map01120 E amidase, hydantoinase carbamoylase COG0624 Cluster_657122 V1229298 SUPH S Hydrolase COG0561 Cluster_657123 V1229299 SURB S G5 domain protein 0ZVV3 Cluster_657124 V1229300 S phage minor capsid protein 0YN5U Cluster_824742 V1229303 DAPD map00300,map01100,map01120,map01230 E Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) COG2171 Cluster_844108 V1229305 BL00800 S YolD-like protein 0XYPA Cluster_657127 V1229306 ARAD map00040,map00053,map01100,map01120 G L-ribulose-5-phosphate 4-epimerase COG0235 Cluster_738067 V1229307 S Protein of unknown function (DUF3343) 0XWDV Cluster_661315 V1229309 GLVR K Transcriptional regulator COG1737 Cluster_657128 V1229310 S ragb susd domaiN-containing protein 0XP53 Cluster_657129 V1229311 CSE4 L Crispr-associated protein, cse4 family 0Y6PV Cluster_661316 V1229312 RLUD J pseudouridine synthase COG0564 Cluster_657130 V1229313 SP_1215 P transporter COG2116 Cluster_661317 V1229314 BL00871 S Phage tail protein 1222P Cluster_657131 V1229315 S Rhodanese domain protein 17KSK@proNOG Cluster_657132 V1229316 ARGS map00970 J arginyl-trna synthetase COG0018 Cluster_657133 V1229317 BCGIA V Type II restriction modification enzyme methyltransferase COG0286 Cluster_661318 V1229320 S NA 11VK0 Cluster_657136 V1229324 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_657139 V1229328 map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_657140 V1229330 map02010 S ABC-2 type transporter 11HPT Cluster_734718 V1229331 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_892177 V1229333 S NA 0XSP9 Cluster_657141 V1229334 ENC_44580 I Inherit from COG: Hemolysin-type calcium-binding COG4222 Cluster_692130 V1229335 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120 G phosphohexose isomerase COG0166 Cluster_661320 V1229337 DPPD map02010 E, P (ABC) transporter COG0444 Cluster_657142 V1229339 PRFC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) COG4108 Cluster_661321 V1229340 NRNA J phosphoesterase RecJ domain protein COG0618 Cluster_674200 V1229341 BA_5405 S Membrane COG2855 Cluster_702299 V1229342 map00240,map00330,map01100 G, M epimerase dehydratase COG0702 Cluster_669795 V1229343 MPTB S Membrane 0XTGY Cluster_661322 V1229344 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_661323 V1229345 MRA_2194 S NA 11IRB Cluster_840054 V1229347 ISCA O iron--sulfur cluster insertion protein erpA COG0316 Cluster_661324 V1229348 S domain protein 0XP9C Cluster_657143 V1229350 MT2794 M LGFP repeat protein COG5479 Cluster_661326 V1229351 E Peptidase family M3 COG1164 Cluster_657144 V1229352 S NA 0ZZGV Cluster_661327 V1229353 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G Phosphohexokinase COG0205 Cluster_661328 V1229354 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_718255 V1229355 HUTH map00340,map01100 E Histidine ammonia-lyase COG2986 Cluster_661330 V1229358 HSDR V type I restriction enzyme EcoKI subunit R COG4096 Cluster_661331 V1229359 U, W domain protein COG5295 Cluster_661334 V1229362 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_661337 V1229366 HEPT map00900,map01110 H synthase COG0142 Cluster_844109 V1229368 YBHK S UPF0052 protein COG0391 Cluster_661338 V1229369 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_744784 V1229370 AROF map00400,map01100,map01110,map01230 E DAHP synthetase I KDSA COG2876 Cluster_661339 V1229371 S Relaxase mobilization nuclease 0Y9PG Cluster_692131 V1229374 S DNA metabolism protein 11MJI Cluster_665490 V1229375 P Transporter COG0733 Cluster_661341 V1229376 E Amino acid permease COG0531 Cluster_661343 V1229378 V Beta-lactamase 0ZWUI Cluster_661344 V1229380 YXIO G major facilitator superfamily COG2270 Cluster_875965 V1229382 AFTA M Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases 0Z57H Cluster_661345 V1229383 NHAC-1 map00680 C Na H antiporter COG1757 Cluster_661346 V1229386 E Alanine racemase domain protein COG3616 Cluster_661347 V1229387 PURB map00230,map00250,map01100,map01110 F Adenylosuccinate lyase COG0015 Cluster_721576 V1229391 RUVX L Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) COG0816 Cluster_665491 V1229392 NHAC-1 map00680 C Na H antiporter COG1757 Cluster_805142 V1229393 CG2284 C uridylyltransferase COG1085 Cluster_661349 V1229396 UHPT P Major Facilitator COG0477 Cluster_665492 V1229398 THIG map00730,map01100 H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) COG2022 Cluster_824743 V1229399 S Protein of unknown function (DUF3073) 0XUJ2 Cluster_661350 V1229400 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_661351 V1229401 AMAA map00360 E Peptidase dimerisation domain COG1473 Cluster_785264 V1229402 SCLAV_2398 T response regulator COG2197 Cluster_708494 V1229404 K HTH_XRE COG1974 Cluster_828561 V1229405 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_665494 V1229407 K transcriptional regulator COG2378 Cluster_661352 V1229410 S Rhodanese domain protein 17KSK@proNOG Cluster_665495 V1229411 GABT map00250,map00280,map00410,map00640,map00650,map01100 E 4-aminobutyrate aminotransferase COG0160 Cluster_665496 V1229412 S NA 0Z1A1 Cluster_718256 V1229413 L terminase (Small subunit) COG3728 Cluster_665498 V1229416 MRPA map00190 P monovalent cation H antiporter subunit A COG2111 Cluster_665499 V1229417 HEML map00860,map01100,map01110 H Glutamate-1-semialdehyde aminotransferase COG0001 Cluster_665500 V1229418 M Glycosyl transferase (Group 1 11H1P Cluster_661353 V1229420 CST2 L CRISPR-associated regulatory protein DevR family COG1857 Cluster_661354 V1229421 MNHD P subunit D COG0651 Cluster_665502 V1229423 V restriction enzyme COG1002 Cluster_665503 V1229424 SP_1215 P transporter COG2116 Cluster_665504 V1229425 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_781135 V1229426 INFA J however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) COG0361 Cluster_824744 V1229428 RIMI S ribosomal-protein-alanine acetyltransferase COG0456 Cluster_904930 V1229429 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_820756 V1229431 MMPL H MMPL domain protein COG2409 Cluster_661355 V1229433 S NA 11NI8 Cluster_751558 V1229434 HPAI map00051,map00350,map01120 G Aldolase COG3836 Cluster_748133 V1229435 GATC map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0721 Cluster_665506 V1229436 S RDD family 0Y3KW Cluster_748134 V1229437 UVRD2 map03420,map03430 L helicase COG2887 Cluster_665507 V1229438 DAPD map00300,map01100,map01120,map01230 E Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) COG2171 Cluster_665509 V1229443 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_665512 V1229446 BIRA map00780,map01100,map02010 H biotin acetyl-CoA-carboxylase ligase COG0340 Cluster_665513 V1229447 map00521,map00523,map01100,map01110 M dTDP-4-dehydrorhamnose 3,5-epimerase COG1898 Cluster_665514 V1229448 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_665515 V1229449 SSGB E HAD-superfamily subfamily IB hydrolase COG0560 Cluster_665517 V1229451 PANC map00410,map00770,map01100,map01110 H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) COG0414 Cluster_665518 V1229454 L resolvase COG1961 Cluster_728202 V1229456 THIN map00730,map01100 H thiamine COG1564 Cluster_687606 V1229457 PGL map00030,map01100,map01110,map01120 G 6-phosphogluconolactonase (EC 3.1.1.31) COG0363 Cluster_848027 V1229458 GLFT1 M Glycosyl transferase, family 2 COG1216 Cluster_665520 V1229459 S NA 101UU Cluster_692132 V1229461 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_665522 V1229464 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_665523 V1229466 M peptidase COG0791 Cluster_711624 V1229467 ARCB map00330,map01110,map01230 E Ornithine cyclodeaminase COG2423 Cluster_665525 V1229471 V restriction modification system DNA specificity domain COG0732 Cluster_789263 V1229472 CLPC O ATP-dependent Clp protease ATP-binding subunit COG0542 Cluster_844111 V1229473 G Major Facilitator superfamily 11Q79 Cluster_665526 V1229475 HTAA S domain protein 11Z68 Cluster_665527 V1229477 M Cell surface protein COG5295 Cluster_665530 V1229480 CG2401 M Secreted protein COG0791 Cluster_669797 V1229481 KDPD map02020 T Osmosensitive K channel His kinase sensor COG2205 Cluster_665532 V1229487 MALQ map00500,map01100 G 4-alpha-glucanotransferase COG1640 Cluster_669799 V1229489 CYSN map00230,map00450,map00920,map01100,map01120 P may be the GTPase, regulating ATP sulfurylase activity (By similarity) COG2895 Cluster_669800 V1229490 AST S Enterotoxin 0YVWS Cluster_816944 V1229491 ANT_21350 E DNA-binding protein COG2856 Cluster_669801 V1229493 PTSG map00010,map00500,map00520,map02060 G PTS system COG2190 Cluster_813168 V1229496 BIOF map00260,map00780,map01100 H 8-amino-7-oxononanoate synthase COG0156 Cluster_669802 V1229497 FADD3 map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG1022 Cluster_665534 V1229500 S conserved protein UCP033563 COG4198 Cluster_669804 V1229501 Q amino acid adenylation domain protein COG1020 Cluster_665535 V1229503 M NLP P60 protein COG0791 Cluster_669806 V1229505 ALGC map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G phosphomannomutase COG1109 Cluster_669808 V1229507 CORA P magnesium and cobalt transport protein CorA COG0598 Cluster_665536 V1229508 DEGV S degv family COG1307 Cluster_665537 V1229509 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_669809 V1229511 S Rib/alpha-like repeat 0YK85 Cluster_909062 V1229513 S NA 0Z6MD Cluster_785265 V1229515 MTGA map00550 M Monofunctional biosynthetic peptidoglycan transglycosylase COG0744 Cluster_665538 V1229516 MAG map03410 L 3-methyladenine DNA glycosylase COG2094 Cluster_669811 V1229517 S NIF3 (NGG1p interacting factor 3) COG0327 Cluster_665539 V1229518 HTPG map04141,map04151,map04612,map04621,map04626,map04914,map04915,map05200,map05215 O Molecular chaperone. Has ATPase activity (By similarity) COG0326 Cluster_669812 V1229519 MALQ map00500,map01100 G 4-alpha-glucanotransferase (EC 2.4.1.25) COG1640 Cluster_669813 V1229522 PIMB M Glycosyl transferase (Group 1 COG0438 Cluster_665542 V1229524 CTAF C Part of cytochrome c oxidase, its function is 11R1D Cluster_669814 V1229525 FTSK D cell division protein FtsK COG1674 Cluster_669816 V1229527 S Protein of unknown function (DUF935) COG2369 Cluster_669818 V1229531 PRPD map00640 S 2-methylcitrate dehydratase COG2079 Cluster_669819 V1229532 RV3778C map00730,map04122 E cysteine desulfurase family protein COG0520 Cluster_758532 V1229533 EAMA E, G Permease of the drug metabolite transporter COG0697 Cluster_789265 V1229534 S NA 0XUR4 Cluster_669820 V1229535 RIBD map00740,map01100 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) COG1985 Cluster_669821 V1229537 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_669823 V1229539 MRPD P Monovalent cation H antiporter subunit D COG0651 Cluster_669824 V1229542 CZCD P cation diffusion facilitator family transporter COG0053 Cluster_669827 V1229546 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_669829 V1229548 HYDF S gtp-binding protein COG1160 Cluster_669831 V1229550 S Membrane 0XSDR Cluster_669832 V1229552 map02010 P Cobalt transport protein COG0619 Cluster_669833 V1229554 PEPX E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) 0XPUZ Cluster_777397 V1229555 TRSE U traE protein COG3451 Cluster_669834 V1229556 ACD map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I Acyl-coa dehydrogenase COG1960 Cluster_669835 V1229557 PPNK map00760,map01100 G Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) COG0061 Cluster_669836 V1229558 HPAF map00350,map01100,map01120 Q Fumarylacetoacetate hydrolase COG0179 Cluster_669837 V1229559 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_674202 V1229560 GBS0386 S domain protein 0XRRR Cluster_669838 V1229561 ANSP E amino acid COG1113 Cluster_721577 V1229564 S Membrane COG3949 Cluster_669839 V1229565 RBSR K LacI family transcriptional regulator COG1609 Cluster_669840 V1229566 S Protein of unknown function (DUF1700) 11XIW Cluster_669841 V1229567 MEGL map00260,map00270,map00450,map00920,map01100,map01110,map01230 E methionine gamma-lyase COG0626 Cluster_669843 V1229570 VP1725 T cbs domain and cyclic nucleotide-regulated nucleotidyltransferase COG2905 Cluster_669846 V1229574 DNAQ map03420,map03430 L Uvrd rep helicase COG2176 Cluster_805143 V1229576 YDCG K Transcriptional regulator COG1476 Cluster_674204 V1229577 ASNB map00250,map00910,map01100,map01110,map01120 E Asparagine synthetase COG0367 Cluster_840056 V1229578 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_734719 V1229579 ISPF map00900,map01100,map01110 I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) COG0245 Cluster_674205 V1229580 THRS map00020,map00300,map00630,map00720,map01100,map01110,map01120,map01210,map01230 C Aconitate hydratase COG1048 Cluster_884173 V1229581 HTH_1030 map02020 T response regulator COG2204 Cluster_711625 V1229582 ANT S Anti-repressor protein 11GG6 Cluster_734720 V1229584 TIG O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COG0544 Cluster_813169 V1229585 NTH map03410 L endonuclease III COG0177 Cluster_669848 V1229587 PIP map00330 L Prolyl aminopeptidase COG0596 Cluster_797012 V1229588 MODB map02010 P molybdate abc transporter COG4149 Cluster_800945 V1229589 Y0750 S Conserved Protein COG3586 Cluster_674207 V1229590 YCEG F aminodeoxychorismate lyase COG1559 Cluster_674209 V1229593 SCPB K Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) COG1386 Cluster_674210 V1229597 S NA 11NI8 Cluster_669850 V1229599 S NA 11NI8 Cluster_674211 V1229602 AFTD S coagulation factor 5 8 type domain-containing protein 0YR9E Cluster_674212 V1229603 S NA 11NI8 Cluster_674213 V1229604 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_674214 V1229605 I May play a role in the intracellular transport of hydrophobic ligands 11G4X Cluster_777398 V1229609 F ATP cone domain COG1328 Cluster_674215 V1229610 MRPD P monovalent cation h antiporter subunit d COG0651 Cluster_674216 V1229611 S Protein of unknown function (DUF690) 11F8D Cluster_674219 V1229615 ATPA map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_674220 V1229619 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_797014 V1229621 S single-stranded DNA-binding protein 11W4C Cluster_674224 V1229625 SURB S G5 domain protein 0ZVV3 Cluster_674225 V1229626 MTRB map02020 T Histidine kinase 0XNMH Cluster_674226 V1229627 SCLAV_0367 V ABC transporter COG1136 Cluster_674227 V1229628 COTH S CotH protein 10HXD Cluster_674228 V1229630 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_678642 V1229631 SCLAV_5207 map00300,map00310,map01100,map01110,map01230 S Saccharopine dehydrogenase COG3268 Cluster_674229 V1229632 M Polysaccharide Biosynthesis Protein 0XP95 Cluster_674231 V1229634 DING L helicase COG1199 Cluster_705390 V1229635 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_674232 V1229638 GLTS E Sodium Glutamate Symporter COG0786 Cluster_678643 V1229641 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_678644 V1229642 map05132 M repeat protein COG3209 Cluster_678645 V1229643 ARSA D Arsenite-activated ATPase (ArsA) COG0003 Cluster_674233 V1229644 SCLAV_0672 P integral membrane protein COG1253 Cluster_678646 V1229645 S NA 16QND@proNOG Cluster_695949 V1229648 S peptidase, S41 11U77 Cluster_678649 V1229651 Y0750 S Conserved Protein COG3586 Cluster_728203 V1229653 map02010 V ABC transporter COG1131 Cluster_678651 V1229657 NUC L nuclease COG1525 Cluster_678653 V1229659 S NIF3 (NGG1p interacting factor 3) COG3323 Cluster_678654 V1229660 S Membrane COG3949 Cluster_674235 V1229661 K, L domain protein COG0553 Cluster_731509 V1229664 APT map00230,map01100 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) COG0503 Cluster_731510 V1229665 S Fic/DOC family 0ZXM7 Cluster_674236 V1229666 NASD map00910,map01120 C nitrite reductase, (NAD(P)H) COG1251 Cluster_678655 V1229667 BMUL_2617 S NA 11QRE Cluster_674237 V1229668 S NA 11NI8 Cluster_674238 V1229669 RBSR K LacI family transcriptional regulator COG1609 Cluster_832283 V1229671 SECA2 map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_674239 V1229676 HYL M polysaccharide lyase family 8 0XTFC Cluster_678660 V1229678 S NA 11HZH Cluster_678661 V1229679 S Membrane 11ZHS Cluster_678662 V1229682 S Nitroreductase 1234Z Cluster_678663 V1229683 RLMB J RNA methyltransferase TrmH family group 3 COG0566 Cluster_678664 V1229684 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_678665 V1229685 DCTP C symporter COG1301 Cluster_678666 V1229687 SURB S G5 domain protein 0ZVV3 Cluster_678667 V1229690 HEMB map00860,map01100,map01110 H delta-aminolevulinic acid dehydratase COG0113 Cluster_678668 V1229691 G Alpha-1,2-mannosidase COG3537 Cluster_678669 V1229692 V ABC transporter COG1132 Cluster_678670 V1229693 S Phage infection protein COG1511 Cluster_678671 V1229694 PCCB I carboxylase, beta COG4799 Cluster_678674 V1229697 OATA I Acyl-transferase COG1835 Cluster_711626 V1229698 K, T Phage shock protein A COG1842 Cluster_683171 V1229699 POTI map02010 P putrescine abc transporter COG1177 Cluster_678675 V1229700 HMUU map02010 P transport system permease protein COG0609 Cluster_683172 V1229701 MT3888 S NA 11KBZ Cluster_683173 V1229702 G extracellular solute-binding protein family 1 0XQ0Q Cluster_744786 V1229703 O Secreted protein COG1651 Cluster_683174 V1229704 RLUD J Pseudouridine synthase COG0564 Cluster_678676 V1229705 map02010 V ABC transporter COG1131 Cluster_678677 V1229707 RSMI G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 Cluster_683176 V1229711 PTRB map05142,map05143 E Oligopeptidase b COG1770 Cluster_678678 V1229712 L DnaB-like helicase N terminal domain COG0305 Cluster_678679 V1229713 YFIC map02010 V ABC transporter COG1132 Cluster_678680 V1229714 S Membrane COG3949 Cluster_683177 V1229716 YITL S S1 RNA binding domain protein COG2996 Cluster_678681 V1229717 MRCB map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_755010 V1229719 S NA 0YGJW Cluster_785266 V1229720 BL01323 M Cell wall binding repeat 2-containing protein 0ZKZU Cluster_683178 V1229721 GLUQ map00860,map00970,map01100,map01110 J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) COG0008 Cluster_678682 V1229724 S ABC transporter, permease COG4120 Cluster_683179 V1229725 S YbbR-like protein COG4856 Cluster_683180 V1229726 NADX map00760,map01100 H Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) COG1712 Cluster_683181 V1229727 GAP map00010,map01100,map01110,map01120,map01230,map04066,map05010 G Glyceraldehyde-3-phosphate dehydrogenase COG0057 Cluster_683183 V1229730 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_683184 V1229731 NTH map03410 L endonuclease III COG0177 Cluster_683185 V1229732 SHC P drug resistance transporter, EmrB QacA subfamily 0XNN3 Cluster_678683 V1229733 M domain protein COG4932 Cluster_683186 V1229735 DEOC map00030 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) COG0274 Cluster_683187 V1229738 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_678684 V1229739 MENA map00130,map01100,map01110 H 1,4-dihydroxy-2-naphthoate octaprenyltransferase COG1575 Cluster_711627 V1229740 L methyltransferase COG3695 Cluster_678685 V1229741 G transporter 0XP7I Cluster_683188 V1229744 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_683191 V1229747 S NA 0ZMA4 Cluster_683192 V1229748 ADDB L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination COG3857 Cluster_683193 V1229750 L adenine specific DNA methyltransferase COG4889 Cluster_683194 V1229752 TRAA L TrwC relaxase COG0507 Cluster_683195 V1229753 G Major Facilitator Superfamily 125HU Cluster_683196 V1229754 S NA 0ZMKZ Cluster_888083 V1229755 PPA map00190 C pyrophosphate phospho-hydrolase COG0221 Cluster_683198 V1229759 ARGF map00330,map01100,map01110,map01230 E ornithine carbamoyltransferase COG0078 Cluster_683200 V1229761 LLDP C L-lactate COG1620 Cluster_683202 V1229765 CAFA map03018 J ribonuclease COG1530 Cluster_871866 V1229767 S Methyltransferase 0XQTC Cluster_683204 V1229768 ICD map00020,map00480,map00720,map01100,map01110,map01120,map01210,map01230,map04146 C Isocitrate dehydrogenase COG2838 Cluster_683208 V1229773 RIBA map00740,map01100 H Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) COG0807 Cluster_809182 V1229774 TRXB map00240,map00450 O thioredoxin reductase COG0492 Cluster_728204 V1229776 BMUL_5818 C Iron-sulfur cluster binding protein COG1139 Cluster_683210 V1229777 MAZG map00230,map00240,map01100 F mazG family COG1694 Cluster_683212 V1229781 GLFT1 M Glycosyl transferase, family 2 COG1216 Cluster_687608 V1229782 GALE map00052,map00520,map01100,map01110 M udp-glucose 4-epimerase COG1087 Cluster_683213 V1229783 P Dyp-type peroxidase family COG2837 Cluster_867931 V1229786 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_683217 V1229794 SUFB O FeS assembly protein SUFB COG0719 Cluster_683218 V1229797 CRTI map00906,map01100,map01110 Q phytoene COG1233 Cluster_758533 V1229798 PNCA map00760,map01100 Q nicotinamidase COG1335 Cluster_718258 V1229799 SCLAV_3212 S NA 0XS1C Cluster_303370 V1022801 SSCG_04100 S YibE F family protein COG5438 Cluster_316583 V1022802 M glycosyl transferase COG0463 Cluster_412072 V1022807 PPIB O PPIases accelerate the folding of proteins COG0652 Cluster_217112 V1022808 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_218226 V1022811 IPDC map00010,map00380,map01100,map01110 E decarboxylase COG3961 Cluster_218227 V1022812 M domain protein COG4932 Cluster_218228 V1022813 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_218229 V1022814 SERB map00260,map00680,map01100,map01120,map01230 E phosphoserine phosphatase COG3830 Cluster_219437 V1022819 KT71_01965 L Transposase COG3436 Cluster_293749 V1022820 L Inherit from COG: Involved in DNA double-strand break repair (DSBR). The Rad50 Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of Mre11 by unwinding and or repositioning DNA ends into the Mre11 active site (By similarity) COG0419 Cluster_219438 V1022822 L helicase COG0553 Cluster_598855 V1022825 RPLS map03010 J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) COG0335 Cluster_404972 V1022831 RPSD map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) COG0522 Cluster_392601 V1022832 V Restriction modification system DNA (Specificity COG0732 Cluster_639979 V1022833 L Phage Integrase Family COG0582 Cluster_231055 V1022835 map00550,map01100 M glycosyl transferase, family 51 COG0744 Cluster_536675 V1022837 P tonB-dependent Receptor 0XNUH Cluster_504190 V1022838 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G Phosphohexokinase COG0205 Cluster_220604 V1022840 COBW S Cobalamin synthesis protein COG0523 Cluster_220605 V1022841 MRCB map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_220606 V1022842 BMUL_2277 L DNA Methylase COG1475 Cluster_482158 V1022844 DOC S Death-On-Curing Family 11N71 Cluster_542261 V1022845 TRMD map00900,map01100,map01110 J Specifically methylates guanosine-37 in various tRNAs (By similarity) COG0336 Cluster_353447 V1022846 map00051,map00510,map01100 M Glycosyl transferase, family 2 COG0463 Cluster_501742 V1022847 P Sodium hydrogen exchanger 0ZT2S Cluster_221785 V1022848 PARC L DNA topoisomerase IV, subunit A COG0188 Cluster_494053 V1022849 M Export protein 11MRX Cluster_464691 V1022852 S isoprenylcysteine carboxyl methyltransferase COG1755 Cluster_727366 V1022853 S Family of unknown function (DUF490) 0Z0C5 Cluster_315021 V1022854 YHBW C Luciferase family COG2141 Cluster_765303 V1022855 NANR K Transcriptional regulator COG2186 Cluster_682175 V1022856 S NA 11EQ5 Cluster_501743 V1022857 S degv family COG1307 Cluster_225295 V1022858 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_222945 V1022859 S phosphoserine phosphatase 0Y1NG Cluster_519826 V1022860 NSRR map05132 K Transcriptional regulator COG1959 Cluster_450568 V1022861 GLPP K glycerol-3-phosphate responsive antiterminator COG1954 Cluster_473124 V1022866 G Trap-type c4-dicarboxylate transport system, small permease component COG3090 Cluster_754167 V1022867 map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map05134 C fumarate reductase succinate dehydrogenase flavoprotein domain protein COG1053 Cluster_289771 V1022868 GLGA map00500,map01100,map01110 G glycogen) synthase COG0438 Cluster_496548 V1022870 GREA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) COG0782 Cluster_222947 V1022872 MT3296 L helicase COG0210 Cluster_272114 V1022874 S Protein of unknown function (DUF559) 121FW Cluster_222948 V1022875 L integrase family 0ZJHZ Cluster_287059 V1022876 map00430,map00620,map00640,map00650,map00680,map00720,map01100,map01120 C phosphate COG0280 Cluster_551264 V1022877 ALDR J endoribonuclease L-psp COG0251 Cluster_423007 V1022879 LYS1 map00300,map00310,map01100,map01110,map01230 E saccharopine dehydrogenase COG1748 Cluster_442553 V1022881 T Histidine kinase COG0642 Cluster_517247 V1022882 SPAR T response regulator COG0745 Cluster_366693 V1022883 P TonB-dependent receptor Plug 0XNPQ Cluster_224125 V1022884 TET38 P MFS family major facilitator transporter, tetracycline cation symporter COG0477 Cluster_363230 V1022885 RADC L DNA repair protein (RadC COG2003 Cluster_519827 V1022887 K Inherit from COG: Transcriptional regulator COG2378 Cluster_539532 V1022888 YKFB S Prophage 17WSD@proNOG Cluster_479826 V1022889 BTUE map00480,map00590 O Glutathione peroxidase COG0386 Cluster_351763 V1022892 E Sodium:solute symporter family COG0591 Cluster_262727 V1022896 AAP map05150 M surface protein 0XSC2 Cluster_289772 V1022903 M Polysaccharide Biosynthesis Protein COG2244 Cluster_226425 V1022905 S NA 11JF2 Cluster_704624 V1022906 S NA 0ZHU9 Cluster_226426 V1022908 COBT map00860,map01100 H Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) COG2038 Cluster_252488 V1022910 G domain protein COG3534 Cluster_519828 V1022911 S NA 11XVQ Cluster_588484 V1022912 S NA 11N77 Cluster_812227 V1022914 map00051,map00500,map00520,map01100 G pfkb domain protein COG0524 Cluster_339284 V1022915 M ompa motb domain protein COG2885 Cluster_566157 V1022922 AHPC O Peroxiredoxin COG0450 Cluster_477458 V1022923 S NA 10WM6 Cluster_754168 V1022925 POLA_2 L DNA polymerase 0XRUF Cluster_394348 V1022926 POLA_2 L DNA polymerase 0XRUF Cluster_421153 V1022928 S NA 129E3 Cluster_598856 V1022929 S secreted protein 0Y4BT Cluster_401405 V1022931 S Membrane COG1738 Cluster_631966 V1022932 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_609624 V1022933 ADHE2 map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map05204 C Dehydrogenase COG1062 Cluster_300552 V1022934 SBTA G Major Facilitator 0Y0M7 Cluster_542262 V1022935 ZRAP map02020 P Binds zinc. Could be an important component of the zinc- balancing mechanism COG3678 Cluster_458410 V1022937 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_331784 V1022939 YDAV L DNA replication protein 17DP6@proNOG Cluster_300553 V1022940 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120 G phosphohexose isomerase COG0166 Cluster_369976 V1022945 S lmbE family COG2120 Cluster_707776 V1022947 L Inherit from COG: Helicase COG1112 Cluster_358445 V1022948 map00440,map01110 M N-acetyltransferase COG1247 Cluster_378474 V1022949 YHBJ S Displays ATPase and GTPase activities (By similarity) COG1660 Cluster_281470 V1022952 V ABC transporter COG1131 Cluster_440535 V1022953 K RNA Polymerase COG1595 Cluster_339285 V1022957 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_396212 V1022958 map00190,map00680,map01100 C V-type ATPase, D subunit COG1394 Cluster_394349 V1022959 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_406711 V1022961 BL01373 L Integrase COG0582 Cluster_232206 V1022963 TOPB map03018 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_446576 V1022964 DAPE map00300,map00330,map01100,map01110,map01120,map01210,map01230 E succinyl-diaminopimelate desuccinylase COG0624 Cluster_799915 V1022968 CSPA K Cold shock protein COG1278 Cluster_387326 V1022969 DLPA map00020,map00290,map00480,map00720,map01100,map01110,map01120,map01210,map01230,map04146 E Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) COG0473 Cluster_468890 V1022971 MRAZ S mraZ protein COG2001 Cluster_239639 V1022972 S HipA domain protein COG3550 Cluster_232207 V1022973 CCRB L Resolvase COG1961 Cluster_499202 V1022974 S Domain of unknown function (DUF1896) 11Y7P Cluster_496549 V1022981 GREA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) COG0782 Cluster_557016 V1022982 HIT F, G Histidine triad (HIT) protein COG0537 Cluster_551265 V1022983 S NA 11EK1 Cluster_233496 V1022984 L helicase COG4646 Cluster_233497 V1022987 S NA 11QZ9 Cluster_233498 V1022989 S membrane protein involved in aromatic hydrocarbon degradation 0YMT5 Cluster_545247 V1022991 S Small integral membrane protein (DUF2273) 0Y6IY Cluster_517248 V1022992 S Membrane 0XTQ0 Cluster_233499 V1022993 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_879005 V1022996 S NA 0ZHU9 Cluster_340740 V1022998 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_683219 V1229801 CSN1 L CRISPR-associated protein, Csn1 family COG3513 Cluster_687612 V1229802 SDAC E Serine transporter COG0814 Cluster_683220 V1229803 S Membrane 12317 Cluster_699228 V1229804 MTNA map00270,map01100 J Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) COG0182 Cluster_797015 V1229805 ISPA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_683221 V1229808 S NA 0Y940 Cluster_748136 V1229809 GLYA map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01230 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) COG0112 Cluster_683222 V1229810 CG2376 S NA 0XX45 Cluster_687613 V1229811 DINF V Mate efflux family protein COG0534 Cluster_687614 V1229814 S radical SAM domain protein COG0535 Cluster_687615 V1229816 MT3296 L helicase COG2887 Cluster_687616 V1229817 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG0194 Cluster_687618 V1229820 YHJE G Metabolite H symporter, major facilitator superfamily (MFS) 16R1Z@proNOG Cluster_687619 V1229821 L DNA methylase n-4 n-6 domain protein COG2189 Cluster_683224 V1229822 F ATP cone domain COG1328 Cluster_683225 V1229823 V HNH endonuclease COG1403 Cluster_687620 V1229827 MVAD map00900,map01100,map01110 I diphosphomevalonate decarboxylase COG3407 Cluster_687621 V1229828 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (alpha subunit) COG0587 Cluster_741481 V1229829 HIGA S Plasmid maintenance system antidote protein COG3093 Cluster_683227 V1229830 HYDE map00780,map01100 H radical SAM domain protein COG0502 Cluster_683228 V1229831 BAS2859 S Membrane COG0730 Cluster_687623 V1229833 GLFT M Transferase COG1216 Cluster_683229 V1229834 ISPF map00900,map01100,map01110 I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) COG0245 Cluster_748137 V1229835 RBSA map02010 G ABC transporter COG1129 Cluster_683230 V1229836 K, L Inherit from COG: helicase COG4646 Cluster_687625 V1229841 DPPB map02010 P ABC transporter (Permease) COG0601 Cluster_687626 V1229844 RECG map03440 L ATP-dependent DNA helicase RecG COG1200 Cluster_687627 V1229845 S NA 17ZXQ@proNOG Cluster_687628 V1229846 EMBC M Arabinosyltransferase 0XSQE Cluster_762304 V1229847 MPRA map02020 T regulatoR COG0745 Cluster_687630 V1229850 S NA 101UU Cluster_687631 V1229852 ALST E amino acid carrier protein COG1115 Cluster_687632 V1229853 map00330,map01100,map01110,map01210,map01230 E peptidase COG0624 Cluster_687634 V1229855 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit epsilon COG0847 Cluster_687635 V1229858 MAZG map00230,map00240,map01100 F mazG family COG1694 Cluster_687636 V1229859 V ABC transporter COG1132 Cluster_687637 V1229862 S Abi-like protein 11J72 Cluster_687638 V1229863 S glycosyltransferase 0Y8FN Cluster_731511 V1229865 PHOR T Histidine kinase 0XNMH Cluster_687639 V1229866 DEOA map00240,map00983,map01100,map05219 F The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) COG0213 Cluster_836177 V1229867 S NA 123NP Cluster_687640 V1229868 S ATP GTP-binding protein 0XNYD Cluster_687641 V1229869 GSHA map00480,map01100 H glutamate--cysteine ligase COG3572 Cluster_692133 V1229871 LIGD map03410,map03420,map03430,map03450 L DNA ligase COG3285 Cluster_692134 V1229872 MT3785 S metallophosphoesterase COG1408 Cluster_687644 V1229875 S NA 11F8K Cluster_773679 V1229876 CMK map00240,map00410,map00770,map01100,map01110 F Cytidine monophosphate kinase COG0283 Cluster_711629 V1229878 S NA COG3937 Cluster_687646 V1229881 LPQC Q polyhydroxybutyrate depolymerase COG3509 Cluster_687647 V1229882 M domain protein COG4932 Cluster_687648 V1229884 GLPX map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120 G Fructose-1,6-bisphosphatase COG1494 Cluster_687649 V1229885 MRPA map00190 P monovalent cation H antiporter subunit A COG2111 Cluster_692136 V1229887 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_687651 V1229888 CCSB O Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) COG1333 Cluster_687652 V1229891 GPH map00630,map01100,map01110 S Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) COG0546 Cluster_687653 V1229892 GLOB map00620 C Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) COG0491 Cluster_755011 V1229893 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_692137 V1229894 K, L domain protein COG0553 Cluster_687654 V1229895 S phospholipase COG4667 Cluster_687655 V1229897 GLTS E Sodium Glutamate Symporter COG0786 Cluster_692139 V1229899 S Inherit from COG: choline binding protein COG5263 Cluster_699230 V1229900 COBQ S Glutamine amidotransferase COG3442 Cluster_820757 V1229901 map02010 P ABC transporter COG1131 Cluster_741482 V1229903 NTH map03410 L endonuclease III COG0177 Cluster_692140 V1229905 SDH map00240,map01100 L Dehydrogenase COG4221 Cluster_687656 V1229906 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_687657 V1229907 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_762306 V1229909 FECE map02010 P ABC transporter, ATP-binding protein COG1120 Cluster_687658 V1229911 SDAC E Serine transporter COG0814 Cluster_692141 V1229913 S NA 0YRPX Cluster_755012 V1229914 map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_692142 V1229915 SBCD L SbcCD D subunit COG0420 Cluster_692143 V1229916 THRB map00260,map01100,map01120,map01230 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) COG0083 Cluster_687660 V1229919 HSLU O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) COG1220 Cluster_692145 V1229920 RIMM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) COG0806 Cluster_692146 V1229921 S Membrane COG3949 Cluster_692147 V1229924 P Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) COG4206 Cluster_705391 V1229926 TMP1 S NA 10C99 Cluster_687661 V1229927 S membrane protein, AbrB duplication COG3180 Cluster_692148 V1229931 MALQ map00500,map01100 G 4-alpha-glucanotransferase COG1640 Cluster_692150 V1229933 THYX map00240,map00340,map00350,map00624,map00670,map01120 F Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) COG1351 Cluster_692151 V1229934 K GntR Family Transcriptional Regulator COG1167 Cluster_789267 V1229936 BMUL_5125 S UPF0317 protein COG4336 Cluster_711630 V1229938 V ATPase associated with various cellular activities aaa_5 COG1401 Cluster_692152 V1229940 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_692154 V1229942 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_766267 V1229945 S doxx family COG2259 Cluster_692157 V1229946 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_692158 V1229947 S Inherit from COG: Abortive infection protein COG1106 Cluster_692159 V1229948 PM1167 P transporter COG0471 Cluster_692160 V1229949 HRRA T regulatoR COG2197 Cluster_800947 V1229950 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_692161 V1229951 GLNE O, T Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) COG1391 Cluster_699231 V1229952 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_721580 V1229953 TYPA T gtp-binding protein typa COG1217 Cluster_762307 V1229955 M Cell wall anchor domain protein 129AF Cluster_762308 V1229956 RNFD C Electron transport complex COG4658 Cluster_68897 V1229957 E, P ABC transporter COG0444 Cluster_1110 V1229958 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_28764 V1229959 S ABC transporter COG0488 Cluster_122158 V1229960 S NA 11FSG Cluster_8590 V1229961 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_75165 V1229962 HSDM V Type I restriction-modification system, M subunit COG0286 Cluster_789268 V1229963 S NA 125T8 Cluster_114207 V1229964 VEX1 V ABC transporter, permease COG0577 Cluster_252750 V1229965 RFBB map02010 P abc transporter COG1134 Cluster_216137 V1229966 DPRA L DNA protecting protein DprA COG0758 Cluster_180327 V1229967 GLYQ map00970 J glycyl-tRNA synthetase, alpha subunit COG0752 Cluster_32848 V1229968 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_89509 V1229970 V restriction 1ANV1@spiNOG Cluster_261677 V1229971 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_182088 V1229972 N Cell surface protein 1CAVF@tenNOG Cluster_72823 V1229973 HTRA map02020 O protease COG0265 Cluster_6753 V1229974 RECG map03420,map03440 L transcription-repair coupling factor COG1197 Cluster_352068 V1229975 S NA 0Y67R Cluster_699232 V1229976 HSDR V type I restriction enzyme EcoKI subunit R COG4096 Cluster_143471 V1229977 HSDS V Restriction modification system DNA (Specificity COG0732 Cluster_96811 V1229978 YLBM S UPF0348 protein COG1323 Cluster_4521 V1229982 SP_1222 V restriction endonuclease 0ZVJ1 Cluster_219627 V1229983 S Type II DNA modification methyltransferase 0ZM02 Cluster_122831 V1229988 COMD map02020 T Histidine kinase COG2972 Cluster_92814 V1229989 O sufB sufD domain protein COG0719 Cluster_11576 V1229991 PQQE K radical SAM domain protein COG1522 Cluster_125411 V1229992 NIRJ L Pyrroloquinoline quinone biosynthesis protein E COG0535 Cluster_46525 V1229993 CYSG map00860,map01100,map01110 H Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) COG1587 Cluster_184686 V1229994 HEMC map00860,map01100,map01110 H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) COG0181 Cluster_37175 V1229996 S NA 0Y9Z0 Cluster_407072 V1230000 M Cell wall binding repeat 2-containing protein COG2247 Cluster_738070 V1230001 I Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) 12B93 Cluster_218470 V1230002 P abc transporter atp-binding protein COG1116 Cluster_497149 V1230003 DPS P Ferritin, Dps family protein COG0783 Cluster_72161 V1230005 GATA map00970,map01100 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) COG0154 Cluster_33638 V1230006 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii subunits gamma and tau COG2812 Cluster_362007 V1230007 K Peptidase S24-like 0XUC3 Cluster_859588 V1230009 S NA 0Y6R4 Cluster_23575 V1230010 L helicase COG1204 Cluster_32849 V1230011 DAM map03430 L Adenine-specific COG3392 Cluster_280373 V1230012 S Inherit from NOG: Relaxase/Mobilisation nuclease domain 0XT8X Cluster_741483 V1230013 S Inherit from COG: Virulence-associated protein e COG4983 Cluster_182089 V1230015 L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) COG0582 Cluster_442991 V1230016 S NA 101EI Cluster_87260 V1230017 S NA 0ZY5S Cluster_57272 V1230020 CASA L crispr-associated protein 0XPA1 Cluster_27182 V1230021 V Type I restriction-modification system R subunit COG4096 Cluster_487301 V1230023 S NA 0XYN9 Cluster_205052 V1230027 S Toprim domain protein 0ZC02 Cluster_345754 V1230031 S phage protein 11I5W Cluster_306567 V1230037 S Band 7 protein 0Y48S Cluster_497150 V1230078 S NA 0XTX8 Cluster_260359 V1230098 map00240,map00670 F Thymidylate synthase complementing protein COG1351 Cluster_523203 V1230103 BMUR_1332 S Domain of Unknown Function (DUF1599) 0XXR0 Cluster_27968 V1230104 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L DNA polymerase COG0749 Cluster_454978 V1230107 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_463069 V1230108 NRDG O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) COG0602 Cluster_36686 V1230109 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_371966 V1230113 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_295445 V1230118 THIG map00730,map01100 H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) COG2022 Cluster_596168 V1230120 K HTH_XRE 126GH Cluster_38675 V1230123 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_49795 V1230124 V Restriction modification system DNA (Specificity COG0732 Cluster_73514 V1230125 S Inherit from NOG: domain protein 0XXVB Cluster_72162 V1230126 L Inherit from COG: Resolvase COG1961 Cluster_560798 V1230127 S NA 11YG8 Cluster_715009 V1230128 L DNA packaging protein 123DA Cluster_18956 V1230129 OCAR_6158 L Terminase, large subunit COG4626 Cluster_766269 V1230130 S NA 0ZXT9 Cluster_68563 V1230131 MOD L DNA methylase COG2189 Cluster_51526 V1230132 S ATP-dependent endonuclease of the OLD family-like protein 0XR0I Cluster_53513 V1230134 PLDB map00564 I alpha beta COG2267 Cluster_434913 V1230135 RIMP S Required for maturation of 30S ribosomal subunits (By similarity) 11NQG Cluster_13173 V1230136 V Type III restriction enzyme, res subunit 0Y2F5 Cluster_793062 V1230137 S NA 0YE9N Cluster_543059 V1230139 L DNA topoisomerase COG0550 Cluster_182990 V1230141 POTD map02010 E ABC transporter COG0687 Cluster_74487 V1230143 S fad dependent oxidoreductase COG2509 Cluster_215004 V1230144 LPLA map00785,map01100 H Lipoate-protein ligase COG0095 Cluster_187321 V1230145 GCVT map00260,map00670,map00910,map01100 E The glycine cleavage system catalyzes the degradation of glycine (By similarity) COG0404 Cluster_107633 V1230146 GCVPA map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG0403 Cluster_98437 V1230147 GCVPB map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG1003 Cluster_127494 V1230148 LPDA map00010,map00020,map00260,map00280,map00620,map01100,map01110,map01120 C Dihydrolipoyl dehydrogenase COG1249 Cluster_19821 V1230149 CLPB O ATP-dependent chaperone protein ClpB COG0542 Cluster_83800 V1230151 RNY S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 Cluster_39477 V1230152 HTPG map04141,map04151,map04612,map04621,map04626,map04914,map04915,map05200,map05215 O Molecular chaperone. Has ATPase activity (By similarity) COG0326 Cluster_391161 V1230153 S NA 11HQM Cluster_264354 V1230154 RFBA map00521,map00523,map01100,map01110 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) COG1209 Cluster_28466 V1230155 S NA 0XQYE Cluster_160382 V1230156 BIOF map00260,map00600,map00780,map01100 E 8-amino-7-oxononanoate synthase COG0156 Cluster_205053 V1230157 DAGK I Diacylglycerol kinase COG1597 Cluster_321399 V1230158 SMTA map00340,map00350,map00624,map01120 J Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) COG4123 Cluster_30478 V1230159 PFLB map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_305178 V1230160 PFLA O Pyruvate formate-lyase COG1180 Cluster_310733 V1230161 S Phospholipase Carboxylesterase COG4099 Cluster_175341 V1230162 TGT J Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COG0343 Cluster_23492 V1230163 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_249055 V1230164 LIPA map00785,map01100 H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) COG0320 Cluster_22871 V1230165 ALR map00300,map00473,map00550,map01100 M Alanine racemase COG0787 Cluster_57768 V1230166 S SusD family 10P1F Cluster_9113 V1230167 P TonB-dependent receptor Plug 0XNPQ Cluster_280374 V1230168 S BadF/BadG/BcrA/BcrD ATPase family 0YXCA Cluster_146515 V1230169 YBBC V conserved protein UCP016719 COG3876 Cluster_99489 V1230170 E solute symporter COG0591 Cluster_17562 V1230171 S Fibronectin type iii domain protein 11FT5 Cluster_102258 V1230172 M group 2 family 0XRCB Cluster_122832 V1230173 AMPG2 E, G, P Beta-lactamase induction signal transducer COG0477 Cluster_141991 V1230174 YBBC V conserved protein UCP016719 COG3876 Cluster_152049 V1230175 S Membrane COG4299 Cluster_279070 V1230176 S n-acetylglucosamine 0ZDER Cluster_54297 V1230177 E GDSL-like Lipase/Acylhydrolase COG2755 Cluster_299469 V1230178 S GSCFA domain protein 0YSVQ Cluster_444978 V1230179 C Flavodoxin COG0716 Cluster_22020 V1230180 S Membrane 0XQXB Cluster_357095 V1230181 MTNN map00270,map01100 F Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) COG0775 Cluster_55989 V1230182 TYPA T gtp-binding protein typa COG1217 Cluster_721582 V1230183 RPSO map03010 J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) COG0184 Cluster_543060 V1230184 FOLK map00790,map01100 H 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase COG0801 Cluster_12752 V1230186 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_29572 V1230187 SPOT map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_107634 V1230188 MLTD M Lytic Murein transglycosylase COG0741 Cluster_321400 V1230189 S NA 11QPY Cluster_252751 V1230190 PARB K parb-like partition protein COG1475 Cluster_318438 V1230191 SOJ D Chromosome Partitioning Protein COG1192 Cluster_313751 V1230192 SURE map00230,map00240,map00760,map01100,map01110 F Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) COG0496 Cluster_172881 V1230193 LPXB map00540,map01100 M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) COG0763 Cluster_315335 V1230194 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_41219 V1230195 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_606878 V1230196 RSFS S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) COG0799 Cluster_338136 V1230197 YFKO C Nitroreductase COG0778 Cluster_48961 V1230198 MT2802 S atpase involved in dna repair 0XNTH Cluster_245161 V1230199 CORA P transporter COG0598 Cluster_576476 V1230200 C, O Rhodanese domain protein COG0526 Cluster_332058 V1230201 S haloacid dehalogenase-like hydrolase COG0637 Cluster_115564 V1230202 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120 G phosphohexose isomerase COG0166 Cluster_216138 V1230203 GPSA map00564 C NADPH-dependent glycerol-3-phosphate dehydrogenase COG0240 Cluster_62375 V1230204 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_101700 V1230205 E solute symporter COG0591 Cluster_57273 V1230206 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG2812 Cluster_629111 V1230207 S Septum formation 0Y0EZ Cluster_303678 V1230208 S (LipO)protein 104XX Cluster_123463 V1230209 PYRC map00240,map01100 F Dihydroorotase COG0044 Cluster_171973 V1230210 S metallophosphoesterase COG1408 Cluster_319923 V1230211 PLSC map00561,map00564,map01100 I Acyl-transferase COG0204 Cluster_326042 V1230212 DPM1 map00510,map01100 M dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) 0XQRC Cluster_116292 V1230213 DAPE1 map00300,map00310,map00330,map00780,map01100,map01110,map01120,map01210,map01230 E peptidase COG0624 Cluster_15405 V1230214 S Organic solvent tolerance protein 0XQ3B Cluster_61812 V1230215 OADA map00020,map00330,map00620,map00720,map01100,map01120,map01230 C Oxaloacetate decarboxylase COG5016 Cluster_95704 V1230216 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_197898 V1230217 S membrane 0Z8C3 Cluster_43890 V1230219 KUP P Transport of potassium into the cell (By similarity) COG3158 Cluster_17495 V1230220 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_85915 V1230222 FUCA map00511 G Alpha-L-fucosidase COG3669 Cluster_2636 V1230223 S NA 0ZHYV Cluster_161214 V1230224 S NA 0XQ5J Cluster_7445 V1230225 PORU S NA 0XPE4 Cluster_398294 V1230226 YCGM map00350,map01100,map01120 Q fumarylacetoacetate (faa) hydrolase COG0179 Cluster_218472 V1230227 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_280375 V1230228 RPSB map03010 J 30S ribosomal protein S2 COG0052 Cluster_576477 V1230229 RPSI map03010 J 30S ribosomal protein S9 COG0103 Cluster_504753 V1230230 RPLM map03010 J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) COG0102 Cluster_10489 V1230231 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_48537 V1230232 S ragb susd domaiN-containing protein 0XP1B Cluster_273719 V1230233 S F5/8 type C domain 12CZN Cluster_51738 V1230234 CADA P cadmium-exporting ATPase COG2217 Cluster_489654 V1230235 COAD map00770,map01100 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) COG0669 Cluster_546003 V1230236 YBEY S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) COG0319 Cluster_73857 V1230237 CTPA M Peptidase, S41 family COG0793 Cluster_41696 V1230238 PARE L Dna topoisomerase iv (Subunit b) COG0187 Cluster_169462 V1230239 S NA 0XRNH Cluster_128895 V1230244 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_560799 V1230245 RNPA J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) 122NB Cluster_324546 V1230246 HEMD map00860,map01100,map01110 H uroporphyrinogeN-iii synthase 0XVP9 Cluster_207233 V1230247 S NA 11VJW Cluster_140513 V1230248 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_154457 V1230249 E peptidase 0XRNU Cluster_51326 V1230250 DEAD map03018 L dead deah box COG0513 Cluster_266993 V1230251 G pfkb domain protein COG0524 Cluster_471527 V1230252 map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_200891 V1230253 YEIH S Membrane COG2855 Cluster_260360 V1230254 LYSR1 K LysR substrate binding domain protein COG0583 Cluster_209402 V1230255 XERD L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_543061 V1230256 AROQ map00400,map01051,map01100,map01110,map01230 E Catalyzes a trans-dehydration via an enolate intermediate (By similarity) COG0757 Cluster_384122 V1230257 MDMC map00340,map00350,map00360,map00624,map00940,map00941,map00945,map01100,map01110,map01120 S O-methyltransferase COG4122 Cluster_215005 V1230258 S Acyltransferase family 0YFSP Cluster_144971 V1230259 map02010 M Efflux ABC transporter, permease protein COG4591 Cluster_321401 V1230261 FRDB map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120 C succinate dehydrogenase fumarate reductase iron-sulfur subunit COG0479 Cluster_805145 V1230262 S s23 ribosomal protein 121RZ Cluster_41041 V1230263 SDHA map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020,map05134 C succinate dehydrogenase, flavoprotein subunit COG1053 Cluster_410700 V1230264 SDHC map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120 C cytochrome b subunit 0YBKA Cluster_50763 V1230265 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_452958 V1230266 APT map00230,map01100 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) COG0503 Cluster_512501 V1230268 DTD J Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) COG1490 Cluster_234897 V1230269 DEOC map00030 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) COG0274 Cluster_224335 V1230270 ISPB map00900,map01110 H synthase COG0142 Cluster_160383 V1230272 map02010 P periplasmic binding protein COG0614 Cluster_1785 V1230273 M Putative cell wall binding repeat 2 COG5492 Cluster_444979 V1230276 APT map00230,map01100 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) COG0503 Cluster_2561 V1230277 U, W surface protein COG5295 Cluster_76767 V1230278 L adenine specific DNA methylase COG2189 Cluster_239888 V1230281 TUAG map00051 M Glycosyl transferase family 2 COG0463 Cluster_695950 V1230282 CLOSA_1745 L transposase COG2963 Cluster_152050 V1230283 S Pilin isopeptide linkage domain protein 1274N Cluster_25498 V1230285 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG2812 Cluster_218473 V1230286 map02010 P ABC transporter COG1131 Cluster_368640 V1230288 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_104002 V1230289 BIRA map00780,map01100 H Biotin- acetyl-CoA-carboxylase ligase COG0340 Cluster_644864 V1230290 S tm2 domain 11XDS Cluster_419739 V1230292 TNPB L transposase COG0675 Cluster_114208 V1230296 ARGG map00250,map00330,map01100,map01110,map01230 E Citrulline--aspartate ligase COG0137 Cluster_213819 V1230298 HTPX map00900 O Protease HtpX homolog COG0501 Cluster_520437 V1230299 LEMA S LemA family COG1704 Cluster_603258 V1230300 S Pfam:DUF1200 0YA60 Cluster_161215 V1230301 MSCS M Mechanosensitive ion channel COG0668 Cluster_275073 V1230302 FABI map00061,map00780,map01100 I Enoyl- acyl-carrier-protein reductase NADH COG0623 Cluster_534474 V1230303 RLPA M rare lipoprotein A COG0797 Cluster_110057 V1230304 GDH map00250,map00330,map00910,map01100 E Glutamate dehydrogenase COG0334 Cluster_254005 V1230305 MENA map00130,map01100,map01110 H 1,4-dihydroxy-2-naphthoate octaprenyltransferase COG1575 Cluster_387730 V1230306 S HD domain protein 11N5F Cluster_250317 V1230307 LPTB map02010 S ABC transporter COG1137 Cluster_353734 V1230308 YRBE Q ABC superfamily ATP binding cassette transporter permease protein COG0767 Cluster_319924 V1230309 Q abc transporter atp-binding protein COG1127 Cluster_157822 V1230310 YGAY G Major Facilitator superfamily 0XNZG Cluster_117717 V1230311 PURB map00230,map00250,map01100,map01110 F adenylosuccinate lyase COG0015 Cluster_104003 V1230312 RLUB J Pseudouridine synthase COG1187 Cluster_107635 V1230313 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_13671 V1230314 S NA 12D1P Cluster_172882 V1230315 FOPA M ompA family 10ZT3 Cluster_515201 V1230316 YJGF J endoribonuclease L-psp COG0251 Cluster_482700 V1230317 FOLA map00670,map00790,map01100 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) COG0262 Cluster_86381 V1230318 SUN map00340,map00350,map00624,map01120 J NOL1 NOP2 sun family protein COG0144 Cluster_378847 V1230319 S NA 0Z62C Cluster_442992 V1230320 RPOE K RNA polymerase COG1595 Cluster_37801 V1230321 M ompa motb domain protein COG2885 Cluster_52592 V1230322 TOPB L Dna topoisomerase COG0550 Cluster_475783 V1230323 GCA map00350,map00362,map00627,map00642,map00903,map01120 L Transferase COG0663 Cluster_99490 V1230324 S iron-regulated transmembrane protein 11UNT Cluster_271053 V1230325 S membrAne 0YEM5 Cluster_499804 V1230326 GREA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) COG0782 Cluster_218474 V1230327 M peptidase, S41 COG0793 Cluster_283117 V1230328 S Protein of unknown function (DUF3316) 11MGD Cluster_16558 V1230329 PARC L DNA topoisomerase IV, subunit A COG0188 Cluster_161216 V1230330 DACB map00550 M d-alanyl-d-alanine carboxypeptidase COG2027 Cluster_377073 V1230331 S NA 11SJ2 Cluster_183806 V1230332 MDSC S Aminoglycoside phosphotransferase 0ZVMN Cluster_109429 V1230333 V Mate efflux family protein COG0534 Cluster_421536 V1230334 MIP O Peptidyl-prolyl cis-trans isomerase COG0545 Cluster_82541 V1230335 GLYQS map00970 J Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) COG0423 Cluster_335060 V1230336 YAAA L UPF0246 protein COG3022 Cluster_537365 V1230337 HSP20 map04141 O Heat shock protein COG0071 Cluster_370353 V1230338 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_407073 V1230339 S Protein of unknown function (DUF3109) 0XQ9F Cluster_262976 V1230340 K transcriptional regulator, arac family 11ZDW Cluster_375302 V1230342 TRPF map00400,map01100,map01110,map01230 E N-(5'-phosphoribosyl)anthranilate isomerase COG0135 Cluster_137479 V1230343 MRAY map00550,map01100 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) COG0472 Cluster_41839 V1230344 M Sulfatase COG1368 Cluster_9567 V1230346 P TonB-dependent receptor Plug 0XNPQ Cluster_38135 V1230347 S SusD family 0XPTK Cluster_276406 V1230348 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_241160 V1230349 RIBD map00740,map01100 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) COG0117 Cluster_144218 V1230350 S Inherit from NOG: antigen PG97 COG4886 Cluster_17431 V1230351 P tonB-dependent Receptor 0XNUH Cluster_87261 V1230353 S NA 11V4N Cluster_112039 V1230354 S Lipoprotein 0YP1K Cluster_13731 V1230355 PQQL O Peptidase, M16 COG0612 Cluster_43705 V1230357 S peptidase C10 11SDT Cluster_216139 V1230359 O AhpC Tsa family 0YT1V Cluster_82542 V1230360 COMM O Mg chelatase subunit ChlI COG0606 Cluster_162889 V1230361 VICK T Histidine kinase 0XQQ4 Cluster_401806 V1230362 S O-methyltransferase-like protein 106VG Cluster_122833 V1230363 MURF map00300,map00550,map01100 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) COG0770 Cluster_141992 V1230364 PRTC map05120 O collagenase COG0826 Cluster_543062 V1230365 SUFE S Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) COG2166 Cluster_10138 V1230366 LACZ map00052,map00511,map00600,map01100 G beta galactosidase small chain COG3250 Cluster_26893 V1230368 G Glycosyl hydrolase family 92 COG3537 Cluster_213820 V1230369 PHYA S Phospholipid glycerol acyltransferase COG3176 Cluster_273720 V1230370 ENC_23920 S Phospholipid glycerol acyltransferase COG3176 Cluster_245162 V1230371 S HTH domain protein 11Z0Z Cluster_119129 V1230372 SUFD O feS assembly protein SufD COG0719 Cluster_321402 V1230373 SUFC O feS assembly ATPase SufC COG0396 Cluster_92815 V1230374 SUFB O FeS assembly protein SUFB COG0719 Cluster_13126 V1230375 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_138243 V1230376 NUSA K Transcription elongation factor NusA COG0195 Cluster_499805 V1230377 RIMP S Required for maturation of 30S ribosomal subunits (By similarity) 11NQG Cluster_66859 V1230378 HLY map04621 S Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation 0XQPX Cluster_13495 V1230379 SPEB S peptidase C10 11SDT Cluster_231272 V1230381 NUCA map04210 F DNA RNA NON-specific endonuclease COG1864 Cluster_292661 V1230383 GPMB map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_485019 V1230384 ISPF map00900,map01100,map01110 I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) COG0245 Cluster_26468 V1230385 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_36398 V1230386 S peptidase 0XPBV Cluster_93297 V1230387 M polysaccharide biosynthesis protein 0XPJ8 Cluster_147288 V1230388 SPMB S nucleoside recognition domain protein COG2715 Cluster_385893 V1230389 PYRE map00240,map00983,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_617952 V1230390 S NA 11UWB Cluster_228944 V1230392 S Sodium bile acid symporter family protein 0YFWN Cluster_38315 V1230393 G Alpha-1,2-mannosidase COG3537 Cluster_327604 V1230394 GPMA map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0588 Cluster_132647 V1230395 YHAM S UPF0597 protein COG3681 Cluster_40863 V1230396 DSBD O Thiol disulfide interchange protein COG4232 Cluster_460950 V1230397 M Membrane 123ZG Cluster_471528 V1230398 OMPH M Membrane 11TPU Cluster_502342 V1230399 OMPH M outer membrane chaperone Skp (OmpH) 11GII Cluster_19206 V1230400 YAET M outer membrane protein assembly complex, YaeT protein COG4775 Cluster_324547 V1230401 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_332059 V1230402 S NA 11MD1 Cluster_105192 V1230403 PG0188 S BNR Asp-box repeat protein 11U9Y Cluster_254006 V1230404 BMUL_5920 S Rhomboid family COG0705 Cluster_184687 V1230405 S Endonuclease Exonuclease phosphatase 11EFS Cluster_11663 V1230406 SECD map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) COG0342 Cluster_336586 V1230407 S NA 0ZP1D Cluster_168533 V1230408 S Acyl-transferase 0XPHK Cluster_203974 V1230409 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_192599 V1230410 RLUD J Pseudouridine synthase COG0564 Cluster_338137 V1230411 map00473,map00550,map01100 S Pasta domain containing protein 120IY Cluster_429011 V1230412 EFP J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) COG0231 Cluster_657145 V1230413 YITW O fes assembly suf system protein COG2151 Cluster_184688 V1230414 S Radical SAM COG0641 Cluster_224336 V1230415 TDH G, M epimerase dehydratase COG0451 Cluster_158693 V1230416 KBL map00260,map00780,map01100 E 2-amino-3-ketobutyrate coenzyme A ligase COG0156 Cluster_494634 V1230417 ARGR K Regulates arginine biosynthesis genes (By similarity) COG1438 Cluster_549052 V1230418 S Thioesterase COG5496 Cluster_382350 V1230419 S NA 11XJU Cluster_342546 V1230420 YBHL S Membrane COG0670 Cluster_54028 V1230421 map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 G Glycosyl hydrolase family 20, catalytic domain protein COG3525 Cluster_199893 V1230422 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_180328 V1230423 TRMI J tRNA (Adenine-N1-)-methyltransferase COG2519 Cluster_1029 V1230424 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_355405 V1230425 PYRE map00240,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_456920 V1230426 S NA 0Z72X Cluster_373586 V1230427 S Pfam:DUF1239 0XW4I Cluster_272383 V1230429 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_60142 V1230430 M Cell wall anchor domain protein 11Q8J Cluster_373587 V1230431 S NA 0Y9SS Cluster_5790 V1230432 U, W Inherit from COG: domain protein 121KM Cluster_840064 V1230433 L NA 0ZPQB Cluster_405402 V1230435 BMUL_5533 S NA 0XPT9 Cluster_30584 V1230436 GLNN map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG3968 Cluster_51923 V1230437 KORA map00020,map00720,map01100,map01120 C 2-oxoacid acceptor oxidoreductase, alpha subunit COG1014 Cluster_212700 V1230438 KORB map00020,map00720,map01100,map01120 C 2-oxoglutarate ferredoxin oxidoreductase subunit beta COG1013 Cluster_252752 V1230439 S Membrane 122M6 Cluster_140514 V1230440 M Glycosyl transferase (Group 1 0XSCX Cluster_312259 V1230441 M group 2 family COG0463 Cluster_47493 V1230442 G alpha amylase, catalytic COG0366 Cluster_45364 V1230443 PULA map00500,map01100,map01110 G Glycogen debranching enzyme COG1523 Cluster_35570 V1230444 SUSB map00052,map00500,map01100 G Alpha-glucosidase 0XNZD Cluster_15846 V1230445 MALQ map00500,map01100,map01110 G 4-alpha-glucanotransferase COG1640 Cluster_206134 V1230446 E peptidase 0XRNU Cluster_494635 V1230449 DPS P ferritin dps family protein COG0783 Cluster_92361 V1230450 PAFA S type i phosphodiesterase nucleotide pyrophosphatase COG1524 Cluster_104599 V1230451 ASPA map00250,map00910,map01100 E Aspartate ammonia-lyase COG1027 Cluster_373588 V1230452 UPP map00240,map01100 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) COG0035 Cluster_74488 V1230453 PCKA map00010,map00020,map00620,map00710,map01100,map01110,map01120 C Phosphoenolpyruvate Carboxylase COG1866 Cluster_71235 V1230454 ARSA map00600,map04142 P Arylsulfatase COG3119 Cluster_30955 V1230456 S phosphate 0XP49 Cluster_338138 V1230457 CYCMA_1561 L Transposase COG3436 Cluster_198895 V1230458 S NA 124VN Cluster_77126 V1230459 S SusD family 0XR6V Cluster_8468 V1230460 P TonB-dependent receptor Plug 0YBDJ Cluster_80164 V1230461 O Alkyl hydroperoxide reductase F subunit COG3634 Cluster_122834 V1230462 G Major Facilitator COG0477 Cluster_68564 V1230464 RLUA J Pseudouridine synthase COG0564 Cluster_606879 V1230465 RPLS map03010 J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) COG0335 Cluster_318439 V1230466 USHA F 5-nucleotidase COG0737 Cluster_326043 V1230467 PORT S porT protein 11H7K Cluster_758536 V1230468 FRX-2 C Ferredoxin 0XW3B Cluster_83009 V1230469 COMEC S ComEC rec2-like protein COG0658 Cluster_8679 V1230470 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_114209 V1230471 PAFA S type i phosphodiesterase nucleotide pyrophosphatase COG1524 Cluster_378848 V1230472 S Pfam:DUF1239 0XW4I Cluster_135067 V1230473 P CBS domain protein COG1253 Cluster_35045 V1230474 O Peptidyl-prolyl cis-trans isomerase 0XT59 Cluster_130340 V1230475 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_809183 V1230476 XSEB map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) 0XUAP Cluster_182090 V1230477 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E brancheD-chain amino acid aminotransferase COG0115 Cluster_183807 V1230478 MRP D ATP-binding protein COG0489 Cluster_137480 V1230479 map02010 V ABC-2 type transporter COG0842 Cluster_165336 V1230480 map02010 V ABC-2 type transporter COG0842 Cluster_219628 V1230481 M Auxiliary transport protein, membrane fusion protein COG0845 Cluster_96292 V1230482 M Outer membrane efflux protein COG1538 Cluster_268406 V1230483 S NA 0ZUS1 Cluster_80165 V1230484 CYDA map00190,map01100,map02020 C (Ubiquinol oxidase) subunit I COG1271 Cluster_170332 V1230485 CYDB map00190,map01100,map02020 C cytochrome D ubiquinol oxidase subunit II COG1294 Cluster_48075 V1230486 map02010 S Permease, YjgP YjgQ family 0XNZX Cluster_152051 V1230487 RIBBA map00740,map01100 H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) COG0807 Cluster_156955 V1230488 AATA map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aminotransferase COG0436 Cluster_291300 V1230489 EXBB U MotA TolQ exbB proton channel COG0811 Cluster_396573 V1230490 EXBD1 P biopolymer transport protein ExbD TolR 11Q4N Cluster_385894 V1230491 EXBD U Biopolymer transport protein exbD tolR 11TA0 Cluster_281717 V1230492 M tonB-dependent Receptor 11HUD Cluster_230096 V1230493 map02010,map02020,map05152 P phosphate abc transporter COG0226 Cluster_102801 V1230494 S tetratricopeptide 11P8K Cluster_100013 V1230495 HEMG map00860,map01100,map01110 H Flavin containing amine oxidoreductase COG1232 Cluster_113507 V1230496 HEMN map00860,map01100,map01110 C coproporphyrinogen COG0635 Cluster_363575 V1230497 S relaxase mobilization nuclease domain protein 0XNXG Cluster_166147 V1230499 GALK map00052,map00520,map01100,map01110 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) COG0153 Cluster_133481 V1230500 GLUP G transporter COG0738 Cluster_186484 V1230501 GALM map00010,map01110,map01120 G converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) COG2017 Cluster_126100 V1230502 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_165337 V1230503 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_403589 V1230504 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_74489 V1230505 YBIT S ABC transporter, ATP-binding protein COG0488 Cluster_251533 V1230506 RLUD J Pseudouridine synthase COG0564 Cluster_582829 V1230507 RBO C Superoxide reductase COG2033 Cluster_477971 V1230508 S NA 0Y3Q9 Cluster_230097 V1230509 S NA 1298D Cluster_91377 V1230510 NUOM map00190,map00910,map01100 C subunit m COG1008 Cluster_42776 V1230511 FBP map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120 G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 COG3855 Cluster_147289 V1230513 map00051 M glycosyl transferase 11GWY Cluster_122159 V1230514 LYSC map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Aspartokinase COG0527 Cluster_279071 V1230515 FTSE map02010 D Cell division ATP-binding protein ftsE COG2884 Cluster_452959 V1230516 T FHA domain protein 11FQP Cluster_183808 V1230517 S sporulation and cell division repeat protein 11WNU Cluster_440984 V1230518 RFBC map00521,map00523,map01100,map01110 M Dtdp-4-dehydrorhamnose 3,5-epimerase COG1898 Cluster_300841 V1230519 S NA 11JB6 Cluster_560800 V1230520 S NA 0YGDJ Cluster_57769 V1230521 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_408845 V1230522 T cyclic nucleotide-binding domain protein COG0664 Cluster_67525 V1230523 S tetratricopeptide repeat 0ZZIS Cluster_69259 V1230524 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_250318 V1230525 S NA 0XSIN Cluster_276407 V1230526 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0847 Cluster_176135 V1230527 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_269748 V1230529 LICD M licD family COG3475 Cluster_108185 V1230530 G hydrolase family 16 11I09 Cluster_657146 V1230531 S NA 12481 Cluster_4511 V1230532 S NA 11P3R Cluster_502343 V1230533 S NA 0YEKU Cluster_8680 V1230534 S NA 0YB2E Cluster_440985 V1230537 S NA 0YB2E Cluster_489655 V1230538 S NA 0Y4E1 Cluster_469365 V1230539 S NA 0YDAR Cluster_497151 V1230540 AMID2 M n-acetylmuramoyl-l-alanine amidase 124HM Cluster_236096 V1230542 S NA 0YREY Cluster_200892 V1230543 CLPP2 map04112 O ATP-dependent Clp protease, proteolytic subunit COG0740 Cluster_370354 V1230544 S Helix-turn-helix 12BYU Cluster_537366 V1230545 S Protein of unknown function (DUF1320) 12DBA Cluster_115565 V1230546 S Protein of unknown function (DUF935) COG4383 Cluster_105193 V1230547 S SPP1 gp7 family 12A6V Cluster_407074 V1230548 S Phage virion morphogenesis family 0Y00D Cluster_517876 V1230551 S NA 12D6A Cluster_38835 V1230552 S NA 0ZUGA Cluster_342547 V1230554 K transcriptional regulator 0YJ72 Cluster_144972 V1230557 DGOT G Major Facilitator 0XR3C Cluster_197899 V1230558 NANM S Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) COG3055 Cluster_9653 V1230559 P TonB-dependent receptor Plug 0Y9HG Cluster_73515 V1230560 S Ragb susd domain-containing protein 0ZKW2 Cluster_284489 V1230561 S NA 0ZEMC Cluster_82543 V1230562 P Type I phosphodiesterase / nucleotide pyrophosphatase COG3119 Cluster_425189 V1230563 map00350,map00362,map00627,map00642,map00903,map01120 S -acetyltransferase 11TPW Cluster_102259 V1230564 NHAD P Na H antiporter COG1055 Cluster_482701 V1230565 ISIB map00910,map01120 C Low-potential electron donor to a number of redox enzymes (By similarity) COG0716 Cluster_452960 V1230566 U Biopolymer transport protein exbD tolR 11JQD Cluster_275074 V1230567 U MotA TolQ exbB proton channel COG0811 Cluster_410702 V1230568 QUEE map00790,map01100 H Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) COG0602 Cluster_375303 V1230569 QUEC map00790,map01100 S Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) COG0603 Cluster_196968 V1230571 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_177791 V1230572 PDXA map00750,map01100 H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) COG1995 Cluster_189886 V1230573 S Uncharacterised protein family (UPF0104) 10F01 Cluster_777399 V1230574 S Protein of unknown function (DUF2795) 11U61 Cluster_100558 V1230575 S NA 0ZT5J Cluster_15508 V1230576 P tonB-dependent receptor plug 0YT3X Cluster_221981 V1230577 S membrane 0XT2N Cluster_93298 V1230578 GLDK O Sulphatase-modifying factor protein COG1262 Cluster_316860 V1230579 GLDL S gliding motility-associated protein GldL 0XPKJ Cluster_81751 V1230580 GLDM S gliding motility-associated protein gldm 0XREI Cluster_201887 V1230581 GLDN S gliding motility protein gldn 0ZWZA Cluster_197900 V1230582 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_213821 V1230583 ASD map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) COG0136 Cluster_35707 V1230584 NAPA P (Na H) antiporter COG0589 Cluster_348952 V1230585 LOLD map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_265683 V1230586 YITL S S1 RNA binding domain protein COG2996 Cluster_463070 V1230587 S dNA-binding protein 0Y077 Cluster_34503 V1230589 DPP map04974 E peptidase COG1506 Cluster_114210 V1230590 YIHY S ribonuclease bn COG1295 Cluster_32078 V1230591 map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_480382 V1230592 NRDG O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) COG0602 Cluster_28864 V1230593 S Pyrogenic exotoxin B 11S8V Cluster_114211 V1230594 S integral membrane protein 0XS1S Cluster_20458 V1230595 NAGH map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 S K01197 hyaluronoglucosaminidase EC 3.2.1.35 0XPBQ Cluster_113508 V1230596 NANH map00511,map00600,map04142 G BNR Asp-box repeat protein COG4409 Cluster_467228 V1230597 S NA 128GQ Cluster_234898 V1230598 map00051,map00510,map01100 M group 2 family COG0463 Cluster_378849 V1230599 T Transcription regulator 101GZ Cluster_73516 V1230600 CTP M Peptidase, S41 family COG0793 Cluster_456921 V1230601 map00670,map01100 H 5-formyltetrahydrofolate cyclo-ligase COG0212 Cluster_5254 V1230602 map00052,map00500,map01100 G F5 8 type C domain protein COG1501 Cluster_674240 V1230603 S Protein of unknown function (DUF721) 12036 Cluster_180329 V1230604 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_350568 V1230605 S domain protein 0XQK0 Cluster_492153 V1230606 RIBH map00740,map01100 H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) COG0054 Cluster_130341 V1230608 NDH map00190 C NADH dehydrogenase COG1252 Cluster_509920 V1230609 S NA 0Y1MD Cluster_625394 V1230610 S RNA polymerase Rpb6 11RMF Cluster_284490 V1230611 YFIO M outer membrane assembly lipoprotein yfio 0ZZRH Cluster_398295 V1230612 S Transcription termination antitermination factor NusG 0YUUM Cluster_363576 V1230613 RPE map00030,map00040,map00710,map01100,map01110,map01120,map01230 G ribulose-phosphate 3-epimerase COG0036 Cluster_408846 V1230614 RPOE K RNA Polymerase 0XT41 Cluster_309290 V1230615 CPN_0542 map02010 P ABC transporter COG1121 Cluster_288699 V1230616 P SNARE associated Golgi protein COG1238 Cluster_287342 V1230617 S Membrane 11QY1 Cluster_138991 V1230618 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_32198 V1230619 PTPA map04974 E peptidase COG1506 Cluster_92362 V1230620 RLML L Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) COG0116 Cluster_79791 V1230621 PCCB map00280,map00630,map00640,map00720,map01100,map01120 I carboxyl transferase domain protein COG4799 Cluster_534475 V1230623 MMDC map00061,map00253,map00620,map00640,map00720,map01100,map01110,map01120 I biotin lipoyl attachment domaiN-containing protein COG4770 Cluster_298190 V1230624 map00500,map01100,map01110 G synthase COG0297 Cluster_108186 V1230625 S (LipO)protein 11J26 Cluster_332060 V1230626 NUDC map00760,map04146 L nadh pyrophosphatase COG2816 Cluster_128896 V1230627 YIEG S Xanthine uracil vitamin C permease COG2252 Cluster_221982 V1230628 S oxidoreductase COG0673 Cluster_184689 V1230629 S NA 124DC Cluster_279072 V1230630 Y2124 S Protein of unknown function (DUF1460) 0YV3U Cluster_387731 V1230631 S outer membrane lipoprotein carrier protein 11YKN Cluster_23033 V1230632 FTSK D cell division protein FtsK COG1674 Cluster_368641 V1230633 S 3-5 exonuclease 11J3A Cluster_159544 V1230634 RLMI S Methyltransferase COG1092 Cluster_122835 V1230635 TILS D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) COG0037 Cluster_114882 V1230636 YQEV J MiaB-like tRNA modifying enzyme COG0621 Cluster_208355 V1230637 M Glycosyl transferase, family 2 COG1216 Cluster_296784 V1230638 S gliding motility protein 0XT55 Cluster_153659 V1230639 SDAAA map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase COG1760 Cluster_523204 V1230640 FUR K regulator Fur family COG0735 Cluster_261678 V1230641 DAPA map00300,map01100,map01110,map01120,map01230 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) COG0329 Cluster_251534 V1230642 E, G Membrane COG0697 Cluster_79792 V1230643 YCBB S ErfK YbiS YcfS YnhG family protein COG2989 Cluster_674241 V1230644 S NA 0YJPQ Cluster_249056 V1230645 RNZ map03013 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) COG1234 Cluster_251535 V1230647 MAZG map00230,map00240,map01100 F mazG family COG1694 Cluster_18412 V1230648 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_141993 V1230649 S Clostripain family 0YH96 Cluster_275075 V1230651 S NA 0ZEMC Cluster_387732 V1230653 S NA 0YKJW Cluster_6731 V1230655 NIFJ map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map00910,map01100,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_158694 V1230656 S AAA ATPase COG1373 Cluster_181157 V1230657 S NA 122PE Cluster_103425 V1230658 G transporter major facilitator family protein 0XRD8 Cluster_33639 V1230659 map00310,map00780,map01100 E Peptidase, S9A B C family, catalytic domain protein COG1506 Cluster_48319 V1230660 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins COG0706 Cluster_75166 V1230661 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_135877 V1230662 S Protein of unknown function (DUF3078) 11J6J Cluster_295446 V1230663 TCMP map00340,map00350,map00624,map01120 Q O-Methyltransferase COG3315 Cluster_3798 V1230664 S Family of unknown function (DUF490) 0XPFA Cluster_114212 V1230665 NQRA C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG1726 Cluster_165338 V1230666 NQRB C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG1805 Cluster_339567 V1230667 NQRC C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG2869 Cluster_392975 V1230668 NQRD C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG1347 Cluster_136687 V1230669 NQRF C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) COG2871 Cluster_232436 V1230670 K hemerythrin hhe cation binding domain protein 11HP7 Cluster_471529 V1230672 K RNA Polymerase 11MBG Cluster_531694 V1230673 S NA 12BPV Cluster_281718 V1230674 S NA 11SU2 Cluster_45954 V1230675 map00500,map01100 G Glycogen debranching enzyme COG3408 Cluster_135878 V1230676 map00051 M Glycosyl transferase (Group 1 COG0438 Cluster_119893 V1230677 AMYA2 map00500,map01100 G hydrolase family 57 COG1449 Cluster_202933 V1230678 ANSA map00250,map00460,map00910,map01100,map01110 E L-asparaginase COG0252 Cluster_102260 V1230679 RUMA map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_94167 V1230681 NQRA C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG1726 Cluster_382351 V1230682 V abc transporter atp-binding protein COG1136 Cluster_245163 V1230683 FLGJ map00511 N, U flagellar rod assembly protein muramidase flgj COG1705 Cluster_62087 V1230684 O m6 family metalloprotease domain protein COG4412 Cluster_606880 V1230685 FRX-2 C Ferredoxin 0XW3B Cluster_353735 V1230686 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG2812 Cluster_209403 V1230688 S membrane 0XT2N Cluster_189887 V1230690 AROQ map00400,map01051,map01100,map01110,map01230 E Catalyzes a trans-dehydration via an enolate intermediate (By similarity) COG0757 Cluster_28765 V1230691 RECG map03440 L ATP-dependent DNA helicase RecG COG1200 Cluster_81752 V1230692 HSDM V HsdM N-terminal domain COG0286 Cluster_185563 V1230693 NEUC map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_560801 V1230694 YFIO M outer membrane assembly lipoprotein yfio 0ZZRH Cluster_213822 V1230695 YICL E, G Transporter COG0697 Cluster_188180 V1230696 S NA 11FQE Cluster_184690 V1230700 S WD40-like beta Propeller containing protein 0YCAG Cluster_266994 V1230701 UDP map00240,map00983,map01100 F Phosphorylase COG2820 Cluster_101140 V1230702 MNME S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 Cluster_58281 V1230703 YFMR S ABC transporter, ATP-binding protein COG0488 Cluster_193484 V1230704 K Transcriptional regulator (LacI family COG1879 Cluster_133482 V1230705 NHAC-1 map00680 C Na H antiporter COG1757 Cluster_335061 V1230707 M hydrolase, family 25 COG3757 Cluster_169463 V1230708 S NA 0Z83I Cluster_526117 V1230709 S NA 0Y4DT Cluster_87262 V1230710 YDDW M YngK protein COG1649 Cluster_407075 V1230711 RIBE map00740,map01100 H riboflavin synthase, subunit alpha COG0307 Cluster_385895 V1230712 GPH map00630,map01100,map01110 S Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) COG0546 Cluster_71516 V1230713 PFK map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G diphosphate--fructose-6-phosphate 1-phosphotransferase COG0205 Cluster_718260 V1230714 S NA 1236P Cluster_463071 V1230715 I Acyltransferase COG0204 Cluster_494636 V1230716 S NA 0YQK2 Cluster_272384 V1230717 map00680,map01120 S esterase COG0627 Cluster_58544 V1230718 RPSA map00900,map01100,map01110,map03010 J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) COG0539 Cluster_41840 V1230719 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_14513 V1230720 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_256444 V1230721 map00051 M group 2 family COG0463 Cluster_336587 V1230722 VICX map03013 S domain protein COG1235 Cluster_165339 V1230724 S (LipO)protein 0XQ9B Cluster_322969 V1230725 S NA 0ZUV1 Cluster_820761 V1230726 RPMG map03010 J 50S ribosomal protein L33 1250Q Cluster_432996 V1230727 CINA H competence damage-inducible protein COG1546 Cluster_206135 V1230728 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_272385 V1230729 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_465150 V1230730 S NA 11PBT Cluster_367033 V1230731 P Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) COG4206 Cluster_63463 V1230732 SFUM_3007 map05100 M Repeat protein COG4886 Cluster_849 V1230735 DPNA L helicase COG4646 Cluster_38676 V1230738 YQFF S Metal Dependent Phosphohydrolase COG1480 Cluster_389428 V1230739 S NA 11IP3 Cluster_42952 V1230740 S NA 0XRT7 Cluster_74184 V1230741 S Ragb susd domain-containing protein 0XPXH Cluster_107056 V1230742 RSEP map04112 M Membrane-associated zinc metalloprotease COG0750 Cluster_156107 V1230743 DXR map00900,map01100,map01110 I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) COG0743 Cluster_469366 V1230744 RIMM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) 11M4J Cluster_126804 V1230745 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_410703 V1230746 S NA 11FTP Cluster_272386 V1230747 YICC map03010 S YicC domain protein COG1561 Cluster_419740 V1230748 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG2852 Cluster_405403 V1230749 NADD map00230,map00760,map01100,map05340 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) COG1057 Cluster_83396 V1230750 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_150453 V1230751 KDTA map00340,map00350,map00540,map00624,map01100,map01120 M 3-Deoxy-D-manno-octulosonic-acid transferase COG1519 Cluster_6838 V1230752 map00511,map04142 G hydrolase family 2, sugar binding COG3250 Cluster_67149 V1230753 RLUA J Pseudouridine synthase COG0564 Cluster_14018 V1230754 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_224337 V1230755 S YitT family COG1284 Cluster_414384 V1230756 RDGB map00230,map00240,map01100 F Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) COG0127 Cluster_42015 V1230757 S Immunoreactive 84 kDa antigen 0Y0NA Cluster_586021 V1230758 S NA 11VCI Cluster_152052 V1230759 FCL map00051,map00520,map01100 M Nad-dependent epimerase dehydratase COG0451 Cluster_141994 V1230760 UGD map00040,map00053,map00500,map00520,map01100,map01110 M UDP-glucose 6-dehydrogenase COG1004 Cluster_140515 V1230761 S NA 0Y00S Cluster_228945 V1230762 G Acyl-transferase COG3594 Cluster_100014 V1230763 ALGI M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_97883 V1230764 M Polysaccharide Biosynthesis Protein 0XP95 Cluster_153660 V1230765 C domain protein 0ZB0Z Cluster_185564 V1230766 map00520,map00550,map01100 C domain protein 0ZQ9H Cluster_176136 V1230768 S Membrane 11TU2 Cluster_219629 V1230769 M glycosyltransferase group 2 family protein COG3955 Cluster_224338 V1230770 M transferase family 2 COG0463 Cluster_223160 V1230771 M glycosyltransferase group 2 family protein COG0463 Cluster_162890 V1230772 S Capsular polysaccharide biosynthesis protein 0XUBN Cluster_202934 V1230773 M glycosyltransferase group 2 family protein COG0463 Cluster_226633 V1230774 M Glycosyl transferase family 2 11UKM Cluster_135879 V1230775 CAPM M Glycosyl transferase (Group 1 0XNZB Cluster_403590 V1230776 PGLC M Bacterial sugar transferase COG2148 Cluster_227770 V1230777 map00240,map00250,map01100 E, F Carbamoyl phosphate synthase-like protein COG0458 Cluster_380578 V1230778 S Had-superfamily hydrolase, subfamily ia, variant 1 COG1011 Cluster_112767 V1230779 PGLE E DegT DnrJ EryC1 StrS aminotransferase COG0399 Cluster_68898 V1230780 AMYA2 map00500 G alpha amylase, catalytic 0XQRS Cluster_114213 V1230783 LGAS_0605 S phage terminase large subunit 0XSCY Cluster_101141 V1230784 S minor capsid protein 0XSIM Cluster_367034 V1230785 S Phage minor structural protein GP20 0Y052 Cluster_271054 V1230786 S Major capsid protein 11IJY Cluster_617953 V1230789 S NA 1232N Cluster_429013 V1230793 S Bacteriophage Gp15 protein 11NHP Cluster_36871 V1230794 S NA COG5412 Cluster_275076 V1230795 ELI_1308 S tail protein 11P2A Cluster_197901 V1230796 ELI_1314 S NA 0XT3I Cluster_507329 V1230798 S toxin secretion phage lysis holin COG4824 Cluster_480383 V1230799 S NA 0YYZU Cluster_523205 V1230800 YBCS S lysozyme COG3772 Cluster_724926 V1230801 S NA 0Z4XF Cluster_473628 V1230805 S NA 0Z2K9 Cluster_345755 V1230806 N Cell surface protein 1DI1G@verNOG Cluster_1528 V1230808 S NA 0Z4Z7 Cluster_458897 V1230810 S NA 0Y6QU Cluster_986 V1230811 S tape measure domain protein 11PSY Cluster_18760 V1230818 S phage terminase large subunit 0ZCYP Cluster_347341 V1230826 S Protein of unknown function (DUF2829) 0Y16Y Cluster_17295 V1230830 map00760,map01100 H NAD synthase 1215K Cluster_10844 V1230832 V Type III COG3587 Cluster_48763 V1230833 MOD map00340,map00350,map00624,map01120 L DNA methylase COG2189 Cluster_813170 V1230834 S NA 0Y1FT Cluster_95206 V1230835 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_16877 V1230836 DNAQ map03420,map03430 L Uvrd rep helicase COG2176 Cluster_251536 V1230837 S Membrane 0XRRH Cluster_554832 V1230838 YHAI S membrAne COG3152 Cluster_836180 V1230839 HPPA map00190 C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for COG3808 Cluster_113509 V1230840 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_135880 V1230841 PURA map00230,map00250,map01100 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis COG0104 Cluster_477972 V1230842 FURR P ferric uptake regulator COG0735 Cluster_43892 V1230843 S peptidase family M49 0XRK4 Cluster_21002 V1230844 S Membrane 0XPM4 Cluster_419741 V1230847 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_221983 V1230848 S YbbR-like protein 11RE7 Cluster_661357 V1230849 YAJC map03060,map03070 U Preprotein translocase YajC subunit COG1862 Cluster_216140 V1230850 NUSB K Involved in the transcription termination process (By similarity) COG0781 Cluster_394796 V1230851 RPLY map03010 J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) COG1825 Cluster_401807 V1230852 PTH J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) COG0193 Cluster_507330 V1230853 HSLR J Heat shock protein COG1188 Cluster_296785 V1230854 S NA 11J85 Cluster_104600 V1230855 S nhl repeat containing protein 12C7Q Cluster_26368 V1230856 P tonB-dependent Receptor 0XP2F Cluster_149589 V1230857 map00550 M Peptidase S13, D-Ala-D-Ala carboxypeptidase C COG2027 Cluster_800949 V1230859 K Transcriptional regulator 121UZ Cluster_38836 V1230860 S M6 family metalloprotease domain protein 0XTK2 Cluster_467229 V1230861 RPLQ map03010 J 50S ribosomal protein l17 COG0203 Cluster_218475 V1230862 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_405405 V1230863 RPSD map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) COG0522 Cluster_582831 V1230864 RPSM map03010 J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits COG0099 Cluster_492154 V1230865 RPLO map03010 J Binds to the 23S rRNA (By similarity) COG0200 Cluster_465151 V1230866 RPSE map03010 J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) COG0098 Cluster_625395 V1230867 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_425191 V1230868 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_566957 V1230869 RPSH map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) COG0096 Cluster_436970 V1230870 RPLE map03010 J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COG0094 Cluster_599680 V1230871 RPLN map03010 J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) COG0093 Cluster_813171 V1230872 RPMC map03010 J 50S ribosomal protein L29 1226R Cluster_534477 V1230873 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_336588 V1230874 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_557738 V1230875 RPLV map03010 J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) COG0091 Cluster_724928 V1230876 RPSS map03010 J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) COG0185 Cluster_289987 V1230877 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_400025 V1230878 RPLC map03010 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 Cluster_678687 V1230879 RPSJ map03010 J Involved in the binding of tRNA to the ribosomes (By similarity) COG0051 Cluster_36264 V1230880 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_492155 V1230881 RPSG map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) COG0049 Cluster_579579 V1230882 RPSL map03010 J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) COG0048 Cluster_246486 V1230883 DCMB map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_758537 V1230885 FLUTA_0256 L Transposase COG3464 Cluster_8873 V1230887 P TonB-dependent receptor Plug 0YBDJ Cluster_77819 V1230888 S (LipO)protein 0YDWI Cluster_201888 V1230889 S NA 11K71 Cluster_131127 V1230890 S NA 0YKNH Cluster_89976 V1230891 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_19376 V1230894 P tonB-dependent Receptor 0XP2F Cluster_265684 V1230896 S NA 126GD Cluster_5233 V1230901 T Histidine kinase 0XNMH Cluster_15948 V1230902 YEEA V methylase COG1002 Cluster_18761 V1230903 S peptidase C10 11SDT Cluster_335062 V1230906 S NA 0Y3TR Cluster_162891 V1230910 MRAY M Glycosyl transferase, family 4 COG0472 Cluster_34352 V1230911 ESTS S sialic acid-specific 9-O-acetylesterase 0XQ2Q Cluster_401808 V1230912 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_377074 V1230913 S DivIVA domain protein 11T6K Cluster_54029 V1230914 LYTC M hydrolase, family 25 COG3757 Cluster_528876 V1230915 S NA 0Y25N Cluster_492156 V1230916 K transcriptional regulator 11Z66 Cluster_312260 V1230917 PYRK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) COG0543 Cluster_254007 V1230918 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate COG0167 Cluster_249057 V1230919 O peptidase, M48 COG0501 Cluster_256445 V1230920 CBIX map00860,map01100 S cobalamin (vitamin b12) biosynthesis cbix protein 0XS6H Cluster_10516 V1230921 P TonB-dependent Receptor Plug Domain 0ZBUC Cluster_105194 V1230922 S SusD family 0YMB2 Cluster_150454 V1230923 S NA 11M0W Cluster_15463 V1230924 O Peptidase, M16 COG0612 Cluster_259049 V1230925 PHUW E Iron-regulated protein COG3016 Cluster_509921 V1230926 NFED O, U Membrane protein implicated in regulation of membrane protease activity COG1585 Cluster_234899 V1230927 HFLC O SPFH domain, Band 7 family protein COG0330 Cluster_185565 V1230928 NEUC map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_43489 V1230929 SILP P copper-exporting ATPase COG2217 Cluster_192600 V1230931 PHEB map00400,map01100,map01110,map01230 E Chorismate mutase COG2876 Cluster_260362 V1230932 E, G EamA-like transporter family COG0697 Cluster_236097 V1230933 S Endonuclease Exonuclease phosphatase 0XPGG Cluster_120621 V1230934 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_266995 V1230935 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_832286 V1230936 S Tetratricopeptide repeat protein 124W9 Cluster_188181 V1230937 VORB map00020,map00280,map00720,map01100,map01120 C 2-oxoglutarate oxidoreductase, alpha subunit COG0674 Cluster_316861 V1230938 VORA map00020,map00280,map00720,map01100,map01120 C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein COG1013 Cluster_89510 V1230939 S NA 11P0I Cluster_198896 V1230940 S Endonuclease Exonuclease phosphatase 0XPGG Cluster_423394 V1230941 MUG L U mismatch-specific DNA glycosylase COG3663 Cluster_391162 V1230942 UDK map00240,map00983,map01100 F uridine monophosphokinase COG0572 Cluster_384123 V1230943 S membrAne 120XT Cluster_4419 V1230944 map00052,map00511,map00600,map01100 G Glycoside hydrolase family 2 COG3250 Cluster_156956 V1230945 NAGC map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 K ROK family COG1940 Cluster_21224 V1230946 S NA 0XPM9 Cluster_22798 V1230947 S NA 0XPM9 Cluster_121391 V1230948 S NA 0Y835 Cluster_341020 V1230949 S NA 0Y3G9 Cluster_97359 V1230950 S SusD family 0YBVT Cluster_9568 V1230951 P TonB-dependent receptor Plug 0XQ9V Cluster_21936 V1230952 P tonB-dependent Receptor 0XQJQ Cluster_252753 V1230953 S NA 0Z9TI Cluster_100559 V1230954 S NA 0ZJXE Cluster_741486 V1230955 RPME2 map03010 J 50s ribosomal protein l31 COG0254 Cluster_243887 V1230956 NUCA map04210 F DNA RNA NON-specific endonuclease COG1864 Cluster_440986 V1230957 GPO map00480,map00590 O Glutathione peroxidase COG0386 Cluster_294036 V1230958 S abc transporter atp-binding protein 11J2E Cluster_213823 V1230959 S abc transporter atp-binding protein 11J2E Cluster_216141 V1230960 V ABC transporter COG1132 Cluster_155296 V1230963 S Pfam:YadA 0YNSE Cluster_28253 V1230964 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_49582 V1230965 S domain protein 0YF83 Cluster_101142 V1230966 RARA L recombination factor protein RarA COG2256 Cluster_31844 V1230967 AST S Enterotoxin 0YVWS Cluster_40864 V1230969 PEPO O Endothelin-converting enzyme 1 COG3590 Cluster_45764 V1230970 S ABC transporter, ATP-binding protein COG0488 Cluster_116997 V1230971 TIG O Trigger factor COG0544 Cluster_347342 V1230972 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_142771 V1230973 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_33390 V1230974 RECQ map03018 L ATP-dependent DNA helicase RecQ COG0514 Cluster_91378 V1230975 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_110058 V1230976 O Peptidyl-prolyl cis-trans isomerase COG0760 Cluster_93748 V1230977 O peptidylprolyl cis-trans isomerase COG0760 Cluster_88573 V1230978 S osta family 0XUST Cluster_53048 V1230980 MUTL map03430 L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) COG0323 Cluster_88118 V1230982 GLNA map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E Glutamate--ammonia ligase, catalytic domain protein COG0174 Cluster_678688 V1230984 RV1313C L transposase, IS204 IS1001 IS1096 IS1165 family protein COG3464 Cluster_208356 V1230985 S DNA-binding protein COG3943 Cluster_266996 V1230989 S NA 11KFV Cluster_387733 V1230990 S NA 11XU3 Cluster_766270 V1230991 S NA 0ZB89 Cluster_512503 V1230994 S NA 0YC0J Cluster_432997 V1230996 S Mu Gam family protein 127RT Cluster_309291 V1230997 Y2191 K Antirepressor COG3617 Cluster_80583 V1230999 SGLY_0535 S phage protein 0XNW6 Cluster_197902 V1231001 S NA 0Z4Z7 Cluster_543063 V1231003 S NA 0YRPX Cluster_485020 V1231005 DOC S Death-On-Curing Family 11N71 Cluster_16441 V1231006 PPDK map00620,map00710,map01100,map01120 G pyruvate phosphate dikinase COG0574 Cluster_28154 V1231007 M Transglycosylase COG5009 Cluster_236098 V1231008 PYRB map00240,map00250,map01100 F aspartate transcarbamylase COG0540 Cluster_509922 V1231009 PYRI map00240,map00250,map01100 F Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) COG1781 Cluster_134271 V1231010 GLYA map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01230 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) COG0112 Cluster_14019 V1231011 S NA 0YAQZ Cluster_102261 V1231013 GLMM map00051,map00520,map01100,map01110 G phosphomannomutase COG1109 Cluster_385896 V1231014 S NA 0Y5ZK Cluster_197903 V1231015 NRNA J phosphoesterase RecJ domain protein COG0618 Cluster_251537 V1231016 S Aminoglycoside phosphotransferase 0XP56 Cluster_336589 V1231017 YEEN K transcriptional regulatory protein COG0217 Cluster_23125 V1231018 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_93299 V1231019 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG0469 Cluster_189027 V1231020 DINB L Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) COG0389 Cluster_97884 V1231022 S NA 0YGFT Cluster_324548 V1231023 S Clostripain 11V6R Cluster_751562 V1231024 INSI L transposase COG2826 Cluster_14128 V1231025 map00500,map01100 N Alpha-L-fucosidase 0XPGV Cluster_8874 V1231026 P TonB-dependent receptor Plug 0YBDJ Cluster_75789 V1231027 S SusD family 0XR6V Cluster_257734 V1231028 S NA 11K71 Cluster_87690 V1231029 S NA 124VN Cluster_189028 V1231030 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_517877 V1231031 S NA 0Z5C1 Cluster_432998 V1231032 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_300842 V1231033 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_205054 V1231034 MUTY map03410 L a g-specific adenine glycosylase COG1194 Cluster_32708 V1231035 L Domain protein COG0507 Cluster_166884 V1231036 P Efflux transporter RND family MFP subunit 0XQIS Cluster_10924 V1231037 CZCA P heavy metal cation efflux protein CzcA COG3696 Cluster_172883 V1231038 M Outer membrane efflux protein 0YF8F Cluster_206136 V1231039 O sugar transferase 11FNX Cluster_196157 V1231041 YAAT S psp1 domain protein COG1774 Cluster_75167 V1231042 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_84284 V1231043 S GH3 auxin-responsive promoter 0ZVFE Cluster_48538 V1231044 S (LipO)protein 0XSFR Cluster_313752 V1231045 S Protein of unknown function (DUF3108) 11Z9Q Cluster_143472 V1231046 PEPR map00310,map00780,map01100 O peptidase, M16 COG0612 Cluster_207234 V1231047 S YitT family COG1284 Cluster_226634 V1231048 TIG O Peptidyl-prolyl cis-trans isomerase COG0545 Cluster_268407 V1231049 TIG O Peptidyl-prolyl cis-trans isomerase COG0545 Cluster_405406 V1231050 FKPB O peptidylprolyl cis-trans isomerase COG0545 Cluster_352069 V1231051 COBB map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_63464 V1231052 P Na Pi-cotransporter COG1283 Cluster_69260 V1231053 UDK map00240,map00983,map01100 F uridine kinase COG0572 Cluster_499806 V1231054 ASNC K regulatory protein, asnc COG1522 Cluster_59884 V1231055 J Glutamine amidotransferase COG2355 Cluster_211617 V1231056 S peptidase m28 0ZVCD Cluster_465153 V1231057 K RNA Polymerase 11MBG Cluster_49372 V1231058 SPEA map00330,map01100 E Catalyzes the biosynthesis of agmatine from arginine (By similarity) COG1166 Cluster_477973 V1231059 AROK map00400,map01100,map01110,map01230 E Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) COG0703 Cluster_27582 V1231060 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG1754 Cluster_321403 V1231061 FHUC map02010 P ABC transporter, ATP-binding protein COG1120 Cluster_42777 V1231064 NAGB map00520,map01100,map01110 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COG0363 Cluster_305179 V1231065 NAGB map00520,map01100,map01110 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COG0363 Cluster_75468 V1231066 map00051,map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 G Glycosyl hydrolase family 20 COG3525 Cluster_447022 V1231067 RPSP map03010 J 30s ribosomal protein S16 COG0228 Cluster_199894 V1231068 GALE map00052,map00520,map01100,map01110 M udp-glucose 4-epimerase COG1087 Cluster_59885 V1231069 PGM map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_629112 V1231070 S Membrane 11UEJ Cluster_497153 V1231071 RLMH S Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) COG1576 Cluster_227771 V1231073 ATPG map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) COG0224 Cluster_77820 V1231074 ATPA map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_492157 V1231075 ATPH map00190,map00195,map01100 C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) COG0712 Cluster_460951 V1231076 ATPF map00190,map00195,map01100 C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) COG0711 Cluster_751563 V1231077 map00190,map00195,map01100 C ATP synthase subunit C 0ZP6E Cluster_210475 V1231078 ATPB map00190,map00195,map01100 C it plays a direct role in the translocation of protons across the membrane (By similarity) COG0356 Cluster_84714 V1231080 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_216142 V1231081 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 C Phosphofructokinase COG0205 Cluster_91379 V1231082 M polysaccharide biosynthesis protein 11G5Z Cluster_674242 V1231083 map00053,map01100,map01120,map02060 G IIb component COG3414 Cluster_208357 V1231084 M Glycosyl transferase, family 2 COG1216 Cluster_259050 V1231086 D Chromosome Partitioning Protein COG1192 Cluster_378850 V1231087 HPAIIM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_47290 V1231090 S NA 11GQ5 Cluster_812 V1231091 S Phage tail tape measure protein, TP901 family 10QPB Cluster_70540 V1231092 O, U Peptidase, S49 COG0616 Cluster_692162 V1231093 S Pfam:DUF2825 1286S Cluster_269749 V1231099 S Phosphoadenosine phosphosulfate reductase 105K1 Cluster_407076 V1231104 S NA 11KVS Cluster_41519 V1231105 S Immunoreactive 84 kDa antigen 0Y0NA Cluster_70238 V1231106 S NA 0YHDF Cluster_103426 V1231107 S Pfam:YadA 0YNSE Cluster_276408 V1231108 ISPE map00900,map01100,map01110 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COG1947 Cluster_28067 V1231109 MAEB map00620,map00710,map01100,map01120 C Malic enzyme COG0281 Cluster_396574 V1231110 K Transcriptional regulator, TetR family 128VI Cluster_31968 V1231111 SPOT map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_86382 V1231112 S NA 0XPYX Cluster_217337 V1231113 MOXR S ATPase family associated with various cellular activities (AAA) COG0714 Cluster_245164 V1231114 S von Willebrand factor COG1721 Cluster_188182 V1231115 S NA 0XQVA Cluster_216143 V1231116 BATA S von Willebrand factor, type A COG2304 Cluster_207235 V1231117 BATB S von Willebrand factor, type A COG2304 Cluster_353736 V1231118 BATC S Tetratricopeptide repeat protein 11U73 Cluster_19529 V1231119 BATD S BatD protein 0XR99 Cluster_352070 V1231120 S acidPPc 11ME9 Cluster_128897 V1231121 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_163691 V1231122 S DNA mismatch repair protein 0ZAAE Cluster_39302 V1231123 NADE map00760,map01100 H Nad synthetase COG0388 Cluster_182091 V1231124 WBSE S Glycosyl transferase 0XSUN Cluster_224339 V1231125 M group 2 family COG0463 Cluster_217338 V1231126 M glycosyl transferase COG0463 Cluster_440987 V1231127 S NA 0YU05 Cluster_715012 V1231129 GROS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) COG0234 Cluster_72824 V1231130 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_18957 V1231131 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_146517 V1231132 S domain protein 0ZZY0 Cluster_156108 V1231133 S domain protein 0ZZY0 Cluster_125412 V1231134 DBPA L dEAD DEAH box helicase COG0513 Cluster_192601 V1231135 SERC map00260,map00680,map00750,map01100,map01120,map01230 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) COG1932 Cluster_249058 V1231136 SERA map00260,map00680,map01100,map01120,map01230 C dehydrogenase COG0111 Cluster_142772 V1231137 S conserved protein UCP033563 COG4198 Cluster_414387 V1231138 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_259051 V1231140 ISPH map00900,map01100,map01110,map03010 I Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) COG0761 Cluster_193485 V1231141 S Protein of unknown function (DUF1573) 11S7I Cluster_2075 V1231142 S alpha-2-macroglobulin COG2373 Cluster_168534 V1231143 FOPA M ompA family 10ZT3 Cluster_76768 V1231144 PURB map00230,map00250,map01100,map01110 F adenylosuccinate lyase COG0015 Cluster_91380 V1231145 O peptidylprolyl cis-trans isomerase COG0760 Cluster_417968 V1231146 map00670,map01100 H 5-formyltetrahydrofolate cyclo-ligase COG0212 Cluster_731513 V1231148 S domain protein 0XNZW Cluster_339568 V1231151 S TonB family 11GC9 Cluster_225510 V1231152 IDSA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_303679 V1231153 TATD L Hydrolase, tatD family COG0084 Cluster_141267 V1231154 S NA 120K9 Cluster_427115 V1231155 SLYD O peptidylprolyl cis-trans isomerase COG1047 Cluster_176956 V1231156 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_132648 V1231157 AGP map00010,map01120 S Phosphatase 0XRK8 Cluster_169464 V1231158 P phosphate-selective porin O and P COG3746 Cluster_318440 V1231159 PHOC map00627,map00740,map01120,map02020 I acid phosphatase COG0671 Cluster_10139 V1231160 S NA 0YTRS Cluster_174523 V1231162 map02010 P Periplasmic binding protein 0XRC7 Cluster_77127 V1231163 NADB map00250,map00760,map01100 H L-aspartate oxidase COG0029 Cluster_218476 V1231164 NADA map00760,map01100 H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) COG0379 Cluster_266997 V1231165 NADC map00760,map01100 H nicotinate-nucleotide pyrophosphorylase COG0157 Cluster_201889 V1231166 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_245165 V1231167 S NA 0Y9TN Cluster_210476 V1231168 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_319925 V1231169 PHNP map00440 S Beta-lactamase domain protein COG1235 Cluster_389429 V1231170 S NA 11VCX Cluster_134272 V1231171 S NA 0Y5M6 Cluster_126101 V1231172 V restriction endonuclease 0Z1AJ Cluster_101143 V1231173 V ATPase associated with various cellular activities aaa_5 COG1401 Cluster_89060 V1231175 DCM map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_150455 V1231176 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_770000 V1231177 STERM_0816 K HTH_XRE 1240S Cluster_384124 V1231178 HSDM V HsdM N-terminal domain COG0286 Cluster_70239 V1231179 L Recombinase COG1961 Cluster_1199 V1231180 U, W Pfam:HIM COG5295 Cluster_592690 V1231182 S MTH538 TIR-like domain (DUF1863) 11U1P Cluster_31845 V1231183 V Type III restriction enzyme, res subunit 0ZVEA Cluster_73149 V1231184 MOD L DNA methylase COG2189 Cluster_368642 V1231187 YBBM S ABC transporter, permease COG0390 Cluster_394797 V1231188 H, P abc transporter atp-binding protein COG1120 Cluster_199895 V1231189 AGUA map00330,map01100 E Agmatine deiminase COG2957 Cluster_31298 V1231191 FUSA2 T elongation factor G COG0480 Cluster_8771 V1231192 S Membrane 0XQTX Cluster_401809 V1231193 G polysaccharide deacetylase COG0726 Cluster_213824 V1231194 QUEG C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) COG1600 Cluster_22799 V1231195 PCRA map03420,map03430 L helicase COG0210 Cluster_336590 V1231196 MTGA map00550 M Monofunctional biosynthetic peptidoglycan transglycosylase COG0744 Cluster_357096 V1231197 M Ompa motb domain protein COG2885 Cluster_91865 V1231198 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) COG0442 Cluster_65995 V1231199 YIDE P transport protein COG2985 Cluster_108798 V1231201 S DNA-binding protein hu 11T81 Cluster_230098 V1231202 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_19671 V1231203 MUTS2 map03430 L muts2 protein COG1193 Cluster_49161 V1231204 YDCP map05120 O Peptidase, U32 family COG0826 Cluster_59886 V1231206 TRAG map03070 U TraG TraD family protein COG3505 Cluster_24693 V1231207 TRSE U traE protein COG3451 Cluster_50362 V1231208 SPL M P60 family COG1705 Cluster_62376 V1231209 TOPB L Dna topoisomerase COG0550 Cluster_169465 V1231210 S Inherit from NOG: DNA repair protein 0XQPN Cluster_2929 V1231213 M domain protein COG4932 Cluster_283118 V1231214 DAM map03430 L Dna adenine methylase COG0338 Cluster_5741 V1231215 V type I restriction-modification system COG0732 Cluster_70890 V1231216 J NOL1/NOP2/sun family COG0144 Cluster_68221 V1231217 FADD map00071,map01100,map03320,map04146,map04920 I Long-chain-fatty-acid--CoA ligase COG1022 Cluster_176137 V1231218 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_247746 V1231219 L DNA uptake protein and related DNA-binding COG1555 Cluster_152886 V1231220 COBW S CobW P47K family protein COG0523 Cluster_68565 V1231221 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_738078 V1231222 RPST map03010 J Binds directly to 16S ribosomal RNA (By similarity) 1220Z Cluster_305180 V1231223 RECO map03440 L Involved in DNA repair and RecF pathway recombination (By similarity) 0XR7P Cluster_573246 V1231224 S NA 0YHD6 Cluster_126102 V1231225 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_264356 V1231226 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_207236 V1231227 FABH map00061,map01100 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) COG0332 Cluster_824746 V1231228 RPMF map03010 J 50S ribosomal protein L32 1241K Cluster_451016 V1231229 S Uncharacterized ACR, COG1399 11J4F Cluster_198897 V1231230 S Acyltransferase 0XZUT Cluster_232437 V1231231 S Acyl-transferase 128XF Cluster_265685 V1231232 UBIA H Prenyltransferase COG0382 Cluster_99491 V1231233 S Membrane 0YHV8 Cluster_13546 V1231234 V Type III restriction enzyme, res subunit 0ZVHQ Cluster_37326 V1231235 L DNA Methylase COG2189 Cluster_396575 V1231236 SP_0666 S Inherit from COG: Alpha beta hydrolase COG0596 Cluster_71826 V1231237 PCT map00620,map00640,map00643,map01100,map01120 I CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) COG4670 Cluster_543064 V1231238 RHAT10 E, G Membrane COG0697 Cluster_570045 V1231239 INSI L transposase COG2826 Cluster_182092 V1231240 THIL map00730,map01100 H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) COG0611 Cluster_160384 V1231241 LPXK map00540,map01100 M Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) COG1663 Cluster_58282 V1231242 SPPA O, U Signal peptide peptidase, SppA COG0616 Cluster_523206 V1231243 RPIB map00030,map00710,map01100,map01110,map01120,map01230 G isomerase B COG0698 Cluster_41384 V1231244 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_184691 V1231245 MANC map00051,map00520,map01100,map01110 M Mannose-1-phosphate guanylyltransferase COG0836 Cluster_318441 V1231246 S NA 11XST Cluster_108799 V1231247 LYSM S Lysm domain protein 12BED Cluster_347343 V1231248 S NA 11NFI Cluster_272387 V1231249 PRMA J Methylates ribosomal protein L11 (By similarity) COG2264 Cluster_71517 V1231251 S membrane protein involved in aromatic hydrocarbon degradation 0YMT5 Cluster_78786 V1231252 RNE map03018 J ribonuclease COG1530 Cluster_425192 V1231253 TMP1 S NA 10C99 Cluster_617954 V1231254 S NA 11EJP Cluster_209404 V1231255 map00051 M Glycosyl transferase, family 2 COG0463 Cluster_377075 V1231256 RPE map00030,map00040,map00710,map01100,map01110,map01120,map01230 G ribulose-phosphate 3-epimerase COG0036 Cluster_4873 V1231257 U, W Pfam:YadA COG5295 Cluster_62901 V1231260 RLUA J Pseudouridine synthase COG0564 Cluster_17143 V1231261 M Export protein COG1596 Cluster_34031 V1231262 S tetratricopeptide repeat 0YK8K Cluster_249059 V1231263 P NMT1/THI5 like COG0715 Cluster_109430 V1231264 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_9528 V1231265 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_81345 V1231266 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_30836 V1231267 map04974 E peptidase COG1506 Cluster_8902 V1231268 P TonB dependent receptor 0XNNV Cluster_106416 V1231269 S SusD family 0YBPW Cluster_134273 V1231270 S NA 0YRA4 Cluster_54999 V1231271 ISPG map00900,map01100,map01110 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) COG0821 Cluster_467230 V1231272 PURE map00230,map01100,map01110 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) COG0041 Cluster_396576 V1231273 S PAP2 superfamily domain protein 126EI Cluster_89511 V1231274 RPON map02020,map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG1508 Cluster_128898 V1231275 S histidine acid phosphatase 0YPZX Cluster_35996 V1231277 IRP P tonB-dependent Receptor COG1629 Cluster_70891 V1231278 S NA 0ZDF1 Cluster_497154 V1231279 NODN I Dehydratase COG2030 Cluster_570046 V1231280 S Protein of unknown function (DUF3408) 0ZA41 Cluster_245166 V1231281 OXYR K Transcriptional regulator 0XNR2 Cluster_29684 V1231282 PRIA map03440 L Primosomal protein n' COG1198 Cluster_230099 V1231283 M 2 glycosyl transferase COG0463 Cluster_157823 V1231284 S Protein of unknown function (DUF2029) 0XT21 Cluster_64843 V1231285 YBIP S Sulfatase COG2194 Cluster_215006 V1231286 LPSA S lipopolysaccharide core biosynthesis protein 0ZUPW Cluster_296786 V1231287 map00051 M Glycosyl transferase, family 2 COG0463 Cluster_166148 V1231288 M glycosyltransferase group 1 family protein COG0438 Cluster_223161 V1231289 HTRB map00540,map01100 M Lipid A Biosynthesis COG1560 Cluster_42953 V1231290 M Sulfatase COG1368 Cluster_69608 V1231291 MSBA map02010 V ABC transporter, ATP-binding protein COG1132 Cluster_188183 V1231292 MANC map00051,map00520,map01100,map01110 M Mannose-1-phosphate guanylyltransferase COG0836 Cluster_168535 V1231293 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG2812 Cluster_129615 V1231294 YAAT S psp1 domain protein COG1774 Cluster_512504 V1231295 GLDH S gliding motility-associated lipoprotein GldH 0ZU07 Cluster_85539 V1231296 S Melibiase 1003M Cluster_93749 V1231297 RODA D rod shape-determining protein RodA COG0772 Cluster_52139 V1231298 MRDA map00550 M Penicillin-binding protein 2 COG0768 Cluster_473629 V1231299 MRED S Rod shape-determining protein MreD 1267M Cluster_296787 V1231300 MREC M Rod shape-determining protein mreC COG1792 Cluster_412510 V1231301 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_5925 V1231302 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III alpha subunit COG0587 Cluster_368643 V1231303 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_330495 V1231304 BIRA map00780,map01100,map02010 H biotin acetyl-CoA-carboxylase ligase COG0340 Cluster_537368 V1231305 SCLAV_4550 L UPF0102 protein COG0792 Cluster_365315 V1231306 ISCU C SUF system FeS assembly protein COG0822 Cluster_112768 V1231307 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_172884 V1231308 ERYC E DegT DnrJ EryC1 StrS COG0399 Cluster_239889 V1231309 S NA 11FYY Cluster_551942 V1231310 WXCM S Domain-Containing protein 11PAN Cluster_169466 V1231311 RFBB map00521,map00523,map01055,map01100,map01110 M dtdp-glucose 4,6-dehydratase COG1088 Cluster_368644 V1231312 S Cytidylate kinase 0XP28 Cluster_114883 V1231313 VMRA V Mate efflux family protein COG0534 Cluster_242537 V1231314 S OmpA family 0Z6DZ Cluster_28254 V1231315 S NA 127I3 Cluster_332061 V1231316 map00633,map01120 C nitroreductase COG0778 Cluster_73858 V1231317 NRDJ map00230,map00240,map01100 F reductase COG0209 Cluster_586023 V1231318 FOLB map00790,map01100 H dihydroneopterin aldolase COG1539 Cluster_88574 V1231319 AMIA M n-acetylmuramoyl-l-alanine amidase COG0860 Cluster_249060 V1231320 S Mammalian cell entry related domain protein 0YWNZ Cluster_302226 V1231321 M Export protein 11MRX Cluster_50363 V1231322 PURF map00230,map00250,map01100,map01110 F amidophosphoribosyltransferase (EC 2.4.2.14) COG0034 Cluster_190747 V1231323 CARA map00240,map00250,map01100 F carbamoyl-phosphate synthetase glutamine chain COG0505 Cluster_145719 V1231324 DCM map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_327605 V1231325 V Type II site-specific deoxyribonuclease 0ZIH9 Cluster_261679 V1231326 PPNK map00760,map01100 G Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) COG0061 Cluster_489656 V1231327 S NA 0XWCR Cluster_392977 V1231328 S HutD COG3758 Cluster_502344 V1231331 S NA 11FB1 Cluster_127495 V1231332 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_494638 V1231333 MRAZ S mraZ protein COG2001 Cluster_239890 V1231334 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_427116 V1231335 S NA 1265D Cluster_34353 V1231336 FTSI map00550 M penicillin-binding protein COG0768 Cluster_96812 V1231337 MURE map00300,map00550,map01100 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_136688 V1231338 MRAY map00550,map01100 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) COG0472 Cluster_118402 V1231339 MURD map00471,map00550,map01100 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COG0771 Cluster_132649 V1231340 FTSW map04112 D cell cycle protein, FtsW RodA SpoVE family COG0772 Cluster_178632 V1231341 MURG map00550,map01100,map04112 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) COG0707 Cluster_112040 V1231342 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_305181 V1231343 FTSQ map04112 S cell division protein 11KRI Cluster_100015 V1231344 FTSA map04112 D This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) COG0849 Cluster_120622 V1231345 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_176957 V1231351 YEGV G Kinase, PfkB family COG0524 Cluster_196969 V1231352 YEGU O ADP-ribosylation crystallin J1 COG1397 Cluster_549053 V1231353 YJEE S protein family UPF0079, ATPase COG0802 Cluster_81346 V1231354 PORX T response regulator 0Y6W0 Cluster_10925 V1231355 S domain protein 0XS27 Cluster_291301 V1231356 CPN_0543 map02010 P (ABC) transporter COG1108 Cluster_157824 V1231357 AROA map00400,map01100,map01110,map01230 E 3-phosphoshikimate 1-carboxyvinyltransferase COG0128 Cluster_296788 V1231358 HEMD map00860,map01100,map01110 H synthase COG1587 Cluster_156957 V1231359 G transporter major facilitator family protein COG0477 Cluster_37802 V1231360 P tonB-dependent Receptor COG1629 Cluster_182991 V1231362 S Domain of unknown function DUF20 COG0628 Cluster_414388 V1231363 TDK map00240,map00983,map01100 F thymidine kinase COG1435 Cluster_371967 V1231364 RSMI G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 Cluster_275077 V1231365 S (LipO)protein 11K11 Cluster_316862 V1231373 LIN1243 S domain protein COG1235 Cluster_232438 V1231374 CLOLE_0796 L recT protein COG3723 Cluster_44661 V1231375 S NA 0XQBQ Cluster_171152 V1231381 L Phage integrase family COG4974 Cluster_257735 V1231382 S YitT family COG1284 Cluster_22619 V1231383 P tonB-dependent Receptor 0XP5Y Cluster_211618 V1231384 N Cell surface protein 0XQ7Y Cluster_26576 V1231385 S peptidase C10 11SDT Cluster_141268 V1231387 FUCP G glucose galactose transporter COG0738 Cluster_27364 V1231388 IRP P tonB-dependent Receptor COG1629 Cluster_181158 V1231390 S NA 0ZT2K Cluster_271055 V1231392 PRMA J Methylates ribosomal protein L11 (By similarity) COG2264 Cluster_373589 V1231393 S NA 122KH Cluster_330496 V1231397 LYC M glycoside hydrolase, family 25 11T0J Cluster_55754 V1231412 P tonB-dependent Receptor 0XQNF Cluster_61813 V1231414 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 Cluster_48539 V1231415 RECQ2 map03018 L ATP-dependent DNA helicase RecQ COG0514 Cluster_154458 V1231416 E peptidase 0XRNU Cluster_105809 V1231417 PEPP E peptidase, M24 COG0006 Cluster_251538 V1231418 RSSA I Phospholipase, patatin family COG4667 Cluster_284491 V1231419 map00770,map01100 H Pantothenate kinase 109YT Cluster_44287 V1231420 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_336591 V1231421 S NA 11G6R Cluster_365316 V1231422 TRMD map00900,map01100,map01110 J Specifically methylates guanosine-37 in various tRNAs (By similarity) COG0336 Cluster_322971 V1231423 K Transcriptional Regulator, LuxR family 0Y1WM Cluster_34198 V1231424 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_210477 V1231429 S NA 11UZG Cluster_202935 V1231431 S CAAX amino terminal protease family 0XUJM Cluster_209405 V1231432 YWTE S hydrolase COG0561 Cluster_249061 V1231436 GALU map00040,map00052,map00500,map00520,map01100,map01110 M UTP-glucose-1-phosphate uridylyltransferase COG1210 Cluster_3119 V1231437 U, W Inherit from COG: domain protein COG5295 Cluster_1357 V1231438 U, W Inherit from COG: domain protein COG5295 Cluster_29443 V1231440 map00052,map00561,map00600,map00603 G alpha-galactosidase 0XPF1 Cluster_24467 V1231442 N Cell surface protein 0XQ7Y Cluster_28353 V1231444 SP_2145 G Alpha-1,2-mannosidase COG3537 Cluster_423395 V1231445 CHRA P Chromate COG2059 Cluster_429014 V1231446 P Chromate COG2059 Cluster_5896 V1231447 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_68566 V1231448 V ABC transporter COG1132 Cluster_254009 V1231449 PPNK map00760,map01100 G Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) COG0061 Cluster_430996 V1231450 THIJ S intracellular protease Pfpi family COG0693 Cluster_362010 V1231451 ISPD map00900,map01100,map01110 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COG1211 Cluster_36872 V1231452 RECG map03440 L ATP-dependent DNA helicase recg COG1200 Cluster_233703 V1231453 M peptidase M23 COG0739 Cluster_28965 V1231456 map00051,map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 G Glycosyl hydrolase family 20, catalytic domain COG3525 Cluster_246487 V1231457 T Anti-feci sigma factor, fecr COG3712 Cluster_7349 V1231458 P TonB-dependent receptor Plug 0XNPQ Cluster_59887 V1231459 S SusD family 11H6B Cluster_81347 V1231460 P Arylsulfatase COG3119 Cluster_336592 V1231461 M Nucleoside-diphosphate-sugar pyrophosphorylase 0ZRVF Cluster_245167 V1231462 S Cdp-alcohol phosphatidyltransferase 0XQPI Cluster_302227 V1231463 I Acyl-ACP thioesterase COG3884 Cluster_166149 V1231464 FOPA M ompA family 10ZT3 Cluster_348953 V1231468 SPL M NlpC/P60 family COG0791 Cluster_184692 V1231469 VORB map00020,map00280,map00720,map01100,map01120 C 2-oxoglutarate oxidoreductase, alpha subunit COG0674 Cluster_104004 V1231471 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_313753 V1231472 J rrna methyltransferase COG0566 Cluster_174524 V1231474 M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) COG4623 Cluster_205056 V1231475 HISC map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01230 E Imidazole acetol-phosphate transaminase COG0079 Cluster_192602 V1231476 YCEG F aminodeoxychorismate lyase COG1559 Cluster_63747 V1231477 GLNS map00970,map01100 J glutaminyL-tRNA synthetase COG0008 Cluster_100016 V1231478 S repeat protein COG0457 Cluster_416164 V1231479 S dedA family COG0586 Cluster_412511 V1231480 map00770 S 4'-phosphopantetheinyl transferase 0XPB1 Cluster_118403 V1231481 GLDE P gliding motility-associated protein GldE COG1253 Cluster_546005 V1231482 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_348954 V1231483 S NA 0YB54 Cluster_177792 V1231485 RLMB map00340,map00350,map00624,map01120 J RNA methyltransferase TrmH family group 3 COG0566 Cluster_18861 V1231486 M domain protein 0ZWTG Cluster_34032 V1231487 FUSA2 T elongation factor G COG0480 Cluster_166150 V1231488 HEMN map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_53514 V1231489 P transporter COG0471 Cluster_321404 V1231490 YGDL H uba thif-type nad fad binding protein COG1179 Cluster_208358 V1231491 map02010 P Iron chelate uptake ABC transporter, FeCT family, permease protein COG0609 Cluster_124100 V1231492 AMPG2 E, G, P Beta-lactamase induction signal transducer COG0477 Cluster_27691 V1231493 M group 2 family 0XRCB Cluster_80584 V1231495 RPRX map02020 T Histidine kinase COG5002 Cluster_182992 V1231496 BMUL_0955 map00030,map01100,map01110,map01120 G 6-phosphogluconolactonase (EC 3.1.1.31) COG2706 Cluster_766272 V1231497 S NA 0XV3U Cluster_98438 V1231498 SPAK T Histidine kinase COG0642 Cluster_371968 V1231499 SPAR T response regulator COG0745 Cluster_330497 V1231500 MUTG map02010 S ABC transporter 11QI3 Cluster_326044 V1231501 map02010 S ABC transporter, permease 11NSJ Cluster_345756 V1231502 MUTF map02010 V ABC transporter, ATP-binding protein COG1131 Cluster_497155 V1231503 S NA COG5412 Cluster_419742 V1231505 S structural protein 11RQ6 Cluster_237296 V1231508 S Structural protein 11PKS Cluster_151218 V1231510 S NA 12BGZ Cluster_103427 V1231511 S Phage portal protein, SPP1 Gp6-like 11J8D Cluster_101144 V1231512 SARE_3718 S Terminase 11NCI Cluster_526118 V1231513 V Hnh endonuclease COG1403 Cluster_283119 V1231517 RECT L recT protein COG3723 Cluster_227772 V1231518 YQAJ L phage-type endonuclease COG5377 Cluster_554834 V1231519 S Endodeoxyribonuclease RusA 0XVTK Cluster_329100 V1231521 K anti-repressor COG3645 Cluster_324549 V1231523 XTH map03410 L Exodeoxyribonuclease III COG0708 Cluster_412512 V1231524 FOLE map00790,map01100 H GTP cyclohydrolase i COG0302 Cluster_281719 V1231525 S sporulation and cell division repeat protein 12AK5 Cluster_319926 V1231526 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_135881 V1231527 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_83010 V1231529 PCNA map03013,map03018 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate COG0617 Cluster_430997 V1231530 PDXT map00750 H Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) COG0311 Cluster_268408 V1231531 PDXS map00750 H Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) COG0214 Cluster_190748 V1231532 THID H phosphomethylpyrimidine kinase COG2207 Cluster_208359 V1231533 FTSX map02010 D Cell division protein FtsX COG2177 Cluster_770001 V1231534 S Signal peptide protein, YSIRK family 1293E Cluster_347344 V1231535 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_164493 V1231536 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_11238 V1231537 M domain protein COG4932 Cluster_271056 V1231539 YUT E UreA transporter COG4413 Cluster_534478 V1231542 S abortive phage infection 0XQE9 Cluster_98965 V1231543 PEPDA E Dipeptidase COG4690 Cluster_190749 V1231544 MENF map00130,map01053,map01100,map01110 H Isochorismate synthase COG1169 Cluster_69938 V1231545 MEND map00130,map01100,map01110 H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) COG1165 Cluster_288702 V1231546 MENB map00130,map01100,map01110 H Naphthoate synthase COG0447 Cluster_192603 V1231547 MENC map00130,map01100,map01110 M mandelate racemase muconate lactonizing COG4948 Cluster_207237 V1231548 MENE map00130,map01100,map01110 H o-succinylbenzoic acid-CoA ligase COG0318 Cluster_52593 V1231549 M Sulfatase COG1368 Cluster_174525 V1231550 AROB map00230,map00400,map01100,map01110,map01230 E 3-dehydroquinate synthase COG0337 Cluster_520439 V1231551 S Toxin-antitoxin system, antitoxin component, HicB family 11KI8 Cluster_32850 V1231552 LKTB3 V ABC transporter, ATP-binding protein COG2274 Cluster_400026 V1231554 RUVA map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) COG0632 Cluster_789272 V1231555 S helix-turn-helix domain protein 122WR Cluster_98966 V1231557 NUON map00190,map00910,map01100 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) COG1007 Cluster_69609 V1231558 L Dna topoisomerase COG0550 Cluster_105810 V1231559 S NA 0Z34Z Cluster_1442 V1231560 BAIB map01054 I, Q Amp-dependent synthetase and ligase COG1020 Cluster_405407 V1231561 ENTD Q Transferase COG2977 Cluster_24184 V1231562 P tonB-dependent Receptor COG4206 Cluster_606882 V1231563 SLIN_0887 L Transposase COG2963 Cluster_285939 V1231565 TATD L Hydrolase, tatD family COG0084 Cluster_142773 V1231566 S NA 120K9 Cluster_408848 V1231567 QUEE map00790,map01100 H Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) COG0602 Cluster_350569 V1231568 INFC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) COG0290 Cluster_625396 V1231569 RPLT map03010 J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) COG0292 Cluster_8625 V1231570 S tonB-dependent receptor plug 0XNX2 Cluster_298192 V1231572 S NA 0YA5G Cluster_225511 V1231573 HPRA map00260,map00630,map00680,map01100,map01110,map01120 C D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain COG1052 Cluster_194425 V1231574 BUK map00650,map01100 C Branched-chain carboxylic acid kinase COG3426 Cluster_252754 V1231575 map00430,map00620,map00640,map00650,map00680,map00720,map01100,map01120 C phosphate COG0280 Cluster_133483 V1231577 HEMN map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_167684 V1231578 BMUL_0955 map00030,map01100,map01110,map01120 G 6-phosphogluconolactonase (EC 3.1.1.31) COG2706 Cluster_777401 V1231579 map00260,map00780,map01100 E Aminotransferase class I and II COG0156 Cluster_38837 V1231580 CCSA O cytochrome C COG0755 Cluster_326045 V1231581 S NA 11T8F Cluster_136689 V1231582 P Phosphate-Selective Porin O and P 10816 Cluster_92363 V1231583 C Thiol oxidoreductase COG3488 Cluster_136690 V1231584 S Imelysin 11RU6 Cluster_122836 V1231585 S Inherit from NOG: Phosphate-Selective Porin O and P 0XQB1 Cluster_330498 V1231586 FHUC map02010 P ABC transporter, ATP-binding protein COG1120 Cluster_589333 V1231587 S NA 11JS4 Cluster_482702 V1231588 S Nucleotidyl transferase of unknown function (DUF1814) 11GBI Cluster_139783 V1231589 S NA 0YDPT Cluster_45955 V1231590 O peptidase s1 and s6 chymotrypsin hap COG0265 Cluster_357097 V1231592 S Tetratricopeptide repeat protein 0XZXZ Cluster_241161 V1231593 I Lipid kinase, YegS Rv2252 BmrU family COG1597 Cluster_246488 V1231594 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_208360 V1231595 GAPA map00010,map01100,map01110,map01120,map01230,map04066,map05010 G Glyceraldehyde-3-phosphate dehydrogenase, type I COG0057 Cluster_554835 V1231596 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_51739 V1231597 S NA 0YKBK Cluster_135882 V1231598 HFLX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COG2262 Cluster_543065 V1231599 RC1_2786 L transposase COG5433 Cluster_18676 V1231600 map00500,map01100,map01110 G, M phosphorylase COG0438 Cluster_67526 V1231601 map00500,map04151,map04910 M synthase COG0438 Cluster_537369 V1231602 S NA 0YHXE Cluster_86822 V1231603 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_14349 V1231605 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_249062 V1231606 FLGJ map00511 N, U flagellar rod assembly protein muramidase flgj COG1705 Cluster_570047 V1231607 map00790,map01100 S 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase 12BSQ Cluster_147290 V1231608 SCLAV_5159 S IgA peptidase M64 0XS18 Cluster_236099 V1231609 PHOH T Phoh family COG1702 Cluster_234900 V1231610 PURC map00230,map01100,map01110 F SAICAR synthetase COG0152 Cluster_333558 V1231611 UBIE map00130,map01100,map01110 H Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) COG2226 Cluster_327606 V1231612 AROE map00400,map01100,map01110,map01230 E Shikimate dehydrogenase COG0169 Cluster_269750 V1231616 ETFB map00910 C Electron transfer flavoprotein COG2086 Cluster_198898 V1231617 ETFA map00910 C Electron transfer flavoprotein COG2025 Cluster_62088 V1231618 ACD map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I Acyl-coa dehydrogenase COG1960 Cluster_97885 V1231619 map03440 L ATP-dependent exodnase (exonuclease v) COG0507 Cluster_292662 V1231620 S NA 11Z9D Cluster_449047 V1231621 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_458898 V1231623 RNHA map03030 S Ribonuclease COG3341 Cluster_232439 V1231624 OPPC2 P abc transporter, permease COG1173 Cluster_473630 V1231625 S NA 0YFUK Cluster_152053 V1231626 map00040,map00500,map01100 S NA 11GMI Cluster_272388 V1231628 S alkaline shock protein COG1302 Cluster_507332 V1231629 S NA 12CJA Cluster_49967 V1231630 S SusD family 0Y9EU Cluster_10140 V1231631 P tonB-dependent Receptor 0XNNV Cluster_44288 V1231632 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_46142 V1231633 S Tetratricopeptide repeat COG0457 Cluster_360437 V1231634 DEF J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) COG0242 Cluster_540169 V1231635 L Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) COG0816 Cluster_477976 V1231636 S sporulation and cell division repeat protein 11VBB Cluster_617955 V1231637 S NA 12490 Cluster_9327 V1231639 G hydrolase family 16 COG2273 Cluster_59888 V1231642 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_570048 V1231643 S Protein of unknown function (DUF1573) 120RE Cluster_430998 V1231644 MAF D MAF-like protein COG0424 Cluster_460952 V1231645 KDSC map00540,map01100 M 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase COG1778 Cluster_421537 V1231646 XPT map00230,map01100,map01110 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) COG0503 Cluster_100560 V1231647 YICE F permease COG2233 Cluster_68899 V1231648 E Dipeptidase COG4690 Cluster_268409 V1231649 S (LipO)protein 0Y5X3 Cluster_6082 V1231650 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_875972 V1231651 L site-specific recombinase, phage integrase family 0ZF8H Cluster_168536 V1231652 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_64022 V1231653 MEND map00130,map01100,map01110 H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) COG1165 Cluster_192604 V1231654 MENC map00130,map01100,map01110 M mandelate racemase muconate lactonizing COG4948 Cluster_173715 V1231655 S kila-n, DNA-binding domain 0XPNQ Cluster_368645 V1231656 RNHA map03030 S ribonuclease COG3341 Cluster_63465 V1231657 S Pfam:DUF2081 COG1479 Cluster_167685 V1231658 CSE4 L Crispr-associated protein, cse4 family 0Y6PV Cluster_138992 V1231659 THII map00730,map01100,map04122 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) COG0301 Cluster_230100 V1231661 MANA map00051,map00520,map01100,map01110 G mannose-6-phosphate isomerase COG1482 Cluster_119130 V1231662 TRKA P Potassium uptake protein COG0569 Cluster_48076 V1231663 DXS map00730,map00900,map01100,map01110 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) COG1154 Cluster_115566 V1231664 PEPC E aminopeptidase c COG3579 Cluster_256447 V1231665 DDH map00300,map01100,map01110,map01230 E Diaminopimelate dehydrogenase 0XPX2 Cluster_12253 V1231666 PPSA S pyruvate phosphate dikinase 0XRDW Cluster_534479 V1231672 BVU_1425 L Transposase COG3039 Cluster_566959 V1231674 OGT L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) COG0350 Cluster_302228 V1231675 V Type II restriction 17WU8@proNOG Cluster_124755 V1231677 AATA map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aminotransferase COG0436 Cluster_162051 V1231678 V Type I restriction modification DNA specificity domain protein COG0732 Cluster_494639 V1231679 V type I restriction-modification system, specificity subunit COG0732 Cluster_401810 V1231680 MOM L DNA modification protein 17ZGC@proNOG Cluster_517878 V1231683 S NA 11JHF Cluster_473631 V1231684 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_412513 V1231686 S NA 11M9C Cluster_295447 V1231688 map00240,map00670 F Thymidylate synthase complementing protein COG1351 Cluster_104601 V1231689 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_502345 V1231692 S Domain of unknown function (DUF3127) 126YQ Cluster_283120 V1231695 SARE_3740 K Antirepressor COG3645 Cluster_357098 V1231697 S NA 0Y6JR Cluster_528877 V1231699 S NA 0YBR7 Cluster_14928 V1231700 M RHS repeat-associated core domain protein COG3209 Cluster_560802 V1231704 M RHS repeat-associated core domain protein COG3209 Cluster_425193 V1231706 S NA 11ZSP Cluster_512505 V1231708 ETFB map00910 C Electron transfer flavoprotein COG2086 Cluster_166151 V1231709 S Membrane 0ZTTH Cluster_172885 V1231711 LYTC map00511 S Glycosyl hydrolases family 25 COG5263 Cluster_292663 V1231716 S NA 11YW7 Cluster_268411 V1231726 RPOS map05111 K RNA polymerase COG0568 Cluster_321405 V1231727 KDSA map00540,map01100 M Phospho-2-dehydro-3-deoxyoctonate aldolase COG2877 Cluster_225512 V1231728 KDSD M Arabinose 5-phosphate isomerase COG0794 Cluster_162052 V1231729 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_401812 V1231730 K transcriptional regulator, luxR family COG2197 Cluster_152887 V1231731 S ATP GTP-binding transmembrane protein 0ZHR8 Cluster_382352 V1231732 V abc transporter atp-binding protein COG1136 Cluster_120623 V1231733 S NA 0Y8NU Cluster_338139 V1231734 S Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) COG1385 Cluster_430999 V1231735 S Pfam:DUF151 11EUJ Cluster_144219 V1231736 NUPG G nucleoside 0ZVFU Cluster_5864 V1231738 GLGB map00500,map01100,map01110 G pullulanase, type i COG1523 Cluster_24185 V1231740 FEOB P Ferrous iron transport protein B COG0370 Cluster_39478 V1231741 S NA 0ZSQZ Cluster_9247 V1231742 map03440 L UvrD REP helicase COG1074 Cluster_13863 V1231743 AASI_0454 S NA 0XPYJ Cluster_734721 V1231745 RIBD map00740,map01100 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) COG0117 Cluster_9455 V1231746 G hydrolase, family 31 COG1501 Cluster_507333 V1231747 GLDH S gliding motility-associated lipoprotein GldH 0ZU07 Cluster_477977 V1231748 QUEF map00790,map01100 S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) COG0780 Cluster_56503 V1231749 MUTS2 L DNA mismatch repair protein COG0249 Cluster_160385 V1231750 map00230,map01100,map01110 F AICARFT/IMPCHase bienzyme COG0138 Cluster_306568 V1231751 YFIH S Multi-copper polyphenol oxidoreductase laccase COG1496 Cluster_160386 V1231752 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_425194 V1231753 ADK map00230,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_449048 V1231754 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_82544 V1231755 NNRD G Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) COG0063 Cluster_199897 V1231756 S NA 11FB1 Cluster_211619 V1231757 FBA map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01230 G Fructose-1,6-bisphosphate aldolase, class II COG0191 Cluster_692163 V1231758 S NA 0ZJP4 Cluster_824750 V1231759 K Transcriptional Regulator, LuxR family 0Y1WM Cluster_316863 V1231760 KDSB map00540,map01100 M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) COG1212 Cluster_172886 V1231761 SP_2027 S MORN repeat protein COG4642 Cluster_35431 V1231762 GLGB map00500,map01100,map01110 G 1,4-alpha-glucan branching enzyme COG0296 Cluster_167686 V1231763 S NA 0YCTM Cluster_401813 V1231765 RUVC map03440 L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) COG0817 Cluster_400028 V1231766 S Metallo-Beta-Lactamase 10GCR Cluster_396578 V1231767 RSMG M Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) COG0357 Cluster_95705 V1231768 S NA 0XSGQ Cluster_487304 V1231769 CDD map00240,map00983,map01100,map05219 F cytidine deaminase COG0295 Cluster_280376 V1231770 S Filamentation induced by cAMP protein fic COG3177 Cluster_120624 V1231772 DGT map00230 F deoxyguanosinetriphosphate triphosphohydrolase-like protein COG0232 Cluster_526119 V1231773 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_55498 V1231774 S tetratricopeptide 0ZVCF Cluster_288703 V1231775 S Lipoprotein 120BJ Cluster_72483 V1231776 M peptidase M23 0XQC5 Cluster_91381 V1231777 S Phage tail tape measure protein 11XTW Cluster_163692 V1231779 V type i restriction COG0732 Cluster_460953 V1231780 V Type I restriction modification DNA specificity domain COG0732 Cluster_299470 V1231781 L Phage Integrase Family COG0582 Cluster_100017 V1231782 V Type I Restriction COG0732 Cluster_166885 V1231783 S Conserved Protein COG4804 Cluster_54298 V1231784 S Protein of unknown function (DUF1524) COG1479 Cluster_102262 V1231785 HSDM V type I restriction-modification system COG0286 Cluster_16270 V1231786 HSDR V type I restriction enzyme EcoKI subunit R COG4096 Cluster_800950 V1231787 S helix-turn-helix domain protein 122WR Cluster_454979 V1231788 O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG0526 Cluster_239891 V1231789 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Ribose-phosphate pyrophosphokinase COG0462 Cluster_425195 V1231790 map00730,map01100 H Thiamine monophosphate synthase 11FJG Cluster_166152 V1231791 NSPC map00330 E Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) COG0019 Cluster_4797 V1231792 L snf2-related protein COG0553 Cluster_131128 V1231793 DINF V Mate efflux family protein COG0534 Cluster_104602 V1231794 RMUC S Dna recombination protein COG1322 Cluster_249063 V1231796 V Restriction modification system DNA (Specificity COG0732 Cluster_196158 V1231799 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_148090 V1231800 LYS1 map00300,map00310,map01100,map01110,map01230 E saccharopine dehydrogenase COG1748 Cluster_333245 V1023002 RSMC J methyltransferase COG2813 Cluster_446577 V1023003 K Transcriptional regulator, TetR family COG1309 Cluster_368320 V1023004 COBB map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_686564 V1023005 COBQ S Glutamine amidotransferase COG3442 Cluster_260128 V1023008 TCMP map00340,map00350,map00624,map01120 Q O-Methyltransferase COG3315 Cluster_237055 V1023015 U, W Pfam:YadA COG5295 Cluster_468891 V1023018 S lysozyme 0YC6U Cluster_624497 V1023019 S NIPSNAP family containing protein 11NIW Cluster_284224 V1023027 S AAA ATPase COG1373 Cluster_325732 V1023030 S Inherit from NOG: antigen PG97 COG4886 Cluster_281471 V1023032 S NA 0XRDH Cluster_530989 V1023033 YBFA K MarR family Transcriptional regulator 176B7@proNOG Cluster_494054 V1023034 NHOA map00232,map00633,map00983,map01100,map01110,map01120,map05204 Q N-hydroxyarylamine O-acetyltransferase COG2162 Cluster_238357 V1023035 U, W Domain-Containing protein COG5295 Cluster_248825 V1023036 HSDR V type I restriction enzyme EcoKI subunit R COG4096 Cluster_788398 V1023038 S NA 0Z81S Cluster_624498 V1023042 RPLT map03010 J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) COG0292 Cluster_240924 V1023046 FRUK-1 map00051 G 1-phosphofructokinase COG1105 Cluster_387327 V1023047 UPP map00240,map01100 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) COG0035 Cluster_383744 V1023049 K phage anti-repressor protein COG3617 Cluster_260129 V1023051 LKTB3 V ABC transporter, ATP-binding protein COG2274 Cluster_491597 V1023052 BFR P Iron-storage protein COG2193 Cluster_754169 V1023054 S prevent-host-death family 124KH Cluster_757742 V1023055 XERD L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_501744 V1023056 YAJC map03060,map03070 U Preprotein translocase subunit YajC 0XVGY Cluster_511889 V1023067 LYSC map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Aspartokinase COG0527 Cluster_530990 V1023068 ASD map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) COG0136 Cluster_819706 V1023069 YHJR S cytoplasmic protein 17NPN@proNOG Cluster_242287 V1023072 SDHA map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020,map05134 C succinate dehydrogenase, flavoprotein subunit COG1053 Cluster_506675 V1023073 S NA 11X5Z Cluster_754170 V1023079 S NA 0ZHU9 Cluster_247516 V1023084 S Zinc ribbon domain protein 0YJTX Cluster_385508 V1023085 PYRE map00240,map00983,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_460467 V1023087 S NA 0YS7C Cluster_426670 V1023088 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_432578 V1023089 DACA map00311,map00312,map00550,map01100,map01110,map02020 M carboxypeptidase COG1686 Cluster_316584 V1023090 GPSA map00564 C NADPH-dependent glycerol-3-phosphate dehydrogenase COG0240 Cluster_635917 V1023093 S Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) 11ENR Cluster_501745 V1023095 RPLO map03010 J Binds to the 23S rRNA (By similarity) COG0200 Cluster_246267 V1023097 U, W Inherit from COG: domain protein COG5295 Cluster_246268 V1023098 M phosphoribosyltransferase COG5663 Cluster_635918 V1023099 GDHA map00250,map00330,map00910,map01100 E Glutamate dehydrogenase COG0334 Cluster_479827 V1023100 S membrane 11VWI Cluster_506676 V1023102 SCLAV_5135 S NA 0YWD2 Cluster_530991 V1023105 M secreted protein COG5479 Cluster_390813 V1023109 Y2124 S Protein of unknown function (DUF1460) 0YV3U Cluster_511890 V1023110 RPSB map03010 J 30S ribosomal protein S2 COG0052 Cluster_247517 V1023121 BL03493 L phage plasmid primase, p4 family COG4983 Cluster_452518 V1023122 V Restriction modification system DNA specificity domain protein COG0732 Cluster_456483 V1023124 S NA 11RX2 Cluster_664528 V1023131 S Protein of unknown function (DUF3467) 11UAG Cluster_473126 V1023133 map04146,map05016 P Manganese and iron superoxide dismutase COG0605 Cluster_578768 V1023134 CHRB T Chromate resistance COG4275 Cluster_562969 V1023136 HISI map00340,map01100,map01110,map01230 E Phosphoribosyl-amp cyclohydrolase COG0139 Cluster_389068 V1023139 S NA 0XV13 Cluster_494055 V1023140 RRAA K Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) COG0684 Cluster_248826 V1023141 S Protein of unknown function DUF262 0ZMV0 Cluster_248827 V1023142 E, H Thiamine pyrophosphate COG0028 Cluster_494056 V1023143 S dNA-binding protein 0Y077 Cluster_247518 V1023144 U, W Pfam:YadA COG5295 Cluster_511892 V1023145 RPLM map03010 J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) COG0102 Cluster_628198 V1023148 V Abortive infection bacteriophage resistance protein COG4823 Cluster_727371 V1023157 L NA 121AE Cluster_250072 V1023160 MANA map00051 G Mannan endo-1,4-beta-mannosidase COG4124 Cluster_276150 V1023161 NDVA V ABC superfamily ATP binding cassette transporter COG1132 Cluster_462590 V1023166 J Uncharacterised ArCR, COG2043 COG1670 Cluster_808226 V1023170 RPMI map03010 J 50s ribosomal protein L35 COG0291 Cluster_609626 V1023171 RPLT map03010 J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) COG0292 Cluster_701616 V1023173 map03440 K Transcriptional regulator COG2865 Cluster_784355 V1023178 S Pfam:PhdYeFM 12BVB Cluster_251306 V1023179 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_261438 V1023181 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120 G phosphohexose isomerase COG0166 Cluster_281472 V1023183 TRMI J tRNA (Adenine-N1-)-methyltransferase COG2519 Cluster_727372 V1023197 J translation initiation factor if-2 COG0532 Cluster_569256 V1023198 SCLAV_4600 K Nucleic-acid-binding protein implicated in transcription termination COG2740 Cluster_363231 V1023199 YFIH S Multi-copper polyphenol oxidoreductase laccase COG1496 Cluster_252490 V1023200 PTSG map00010,map00500,map00520,map02060 G PTS system COG2190 Cluster_380580 V1231801 S NA 1204F Cluster_353738 V1231802 CMK map00240,map00410,map00770,map01100,map01110 F Cytidine monophosphate kinase COG0283 Cluster_363577 V1231803 RLUC J pseudouridine synthase COG0564 Cluster_324550 V1231804 FABG map00061,map00780,map01040,map01100 I 3-oxoacyl- acyl-carrier-protein reductase 0XNW1 Cluster_412514 V1231805 K Transcriptional regulator, TetR family 11IXV Cluster_165340 V1231806 L site-specific recombinase, phage integrase family 11T44 Cluster_256448 V1231808 C iron-sulfur 11G02 Cluster_207238 V1231809 YDJZ S SNARE associated Golgi protein-related protein COG0398 Cluster_46921 V1231810 map00680,map01120 S Phosphotransferase 0Y7VB Cluster_138993 V1231811 FABF map00061,map00780,map01100 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) COG0304 Cluster_196159 V1231812 RNC map03008,map05205 K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) COG0571 Cluster_440988 V1231816 S Domain of unknown function (DUF3332) 11RNE Cluster_392978 V1231817 AASI_0458 S WbqC-like 0ZW99 Cluster_97886 V1231819 LEPB map03060 U Signal peptidase I COG0681 Cluster_295448 V1231820 DAPB map00300,map01100,map01110,map01120,map01230 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) COG0289 Cluster_35997 V1231821 IRP P tonB-dependent Receptor COG1629 Cluster_131129 V1231823 V Type I restriction modification DNA specificity domain COG0732 Cluster_9470 V1231825 map03440 L UvrD REP helicase COG1074 Cluster_34354 V1231826 S NA 0ZSQZ Cluster_73517 V1231827 S domain protein 0YF83 Cluster_162053 V1231828 O Antioxidant, AhpC TSA family 0ZMYB Cluster_289988 V1231829 XYNB I esterase COG0657 Cluster_231273 V1231830 S Prolyl oligopeptidase family COG1073 Cluster_18862 V1231831 ACA4 P Calcium-translocating P-type ATPase, PMCA-type COG0474 Cluster_400029 V1231832 S HAD hydrolase, family IA, variant 3 COG1011 Cluster_237297 V1231833 RIBF map00740,map01100 H riboflavin biosynthesis protein ribF COG0196 Cluster_546006 V1231835 S NA 0YIA5 Cluster_777402 V1231836 S NA 0YIA5 Cluster_129616 V1231838 S Pyrogenic exotoxin B 11S8V Cluster_352071 V1231839 S NA 0YM6Q Cluster_377076 V1231840 S NA 0YM6Q Cluster_766274 V1231843 J RNA methyltransferase COG2265 Cluster_8954 V1231846 V Eco57I restriction-modification methylase COG1002 Cluster_523208 V1231851 S plasmid recombination enzyme 1004W Cluster_251539 V1231852 S NA 0ZZWZ Cluster_259052 V1231853 S NA 11F5E Cluster_234901 V1231856 L exonuclease 0XQA5 Cluster_122838 V1231857 E Inherit from COG: amidohydrolase COG1473 Cluster_7299 V1231858 V restriction COG1002 Cluster_107636 V1231859 K Transcriptional regulator COG2865 Cluster_3185 V1231860 S Family of unknown function (DUF490) 0Z0C5 Cluster_25901 V1231861 M Outer membrane protein, OMP85 family 0XNPU Cluster_400030 V1231863 S integral membrane protein 11P1U Cluster_665546 V1231864 S Phage replisome organizer 0ZW0Q Cluster_632940 V1231865 S Addiction module antitoxin, RelB DinJ family 0XUTM Cluster_288704 V1231873 S Phage Tail Tape Measure Protein COG5283 Cluster_260364 V1231874 M group 2 family COG0463 Cluster_718263 V1231875 S Inherit from COG: ATPase (AAA COG1373 Cluster_187322 V1231876 M Glycosyl transferases group 1 101RD Cluster_193486 V1231877 M glycosyl transferase group 1 COG0438 Cluster_45366 V1231879 PULA map00500,map01100,map01110 G Glycogen debranching enzyme COG1523 Cluster_456924 V1231880 NAGB map00520,map01100,map01110 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COG0363 Cluster_141269 V1231881 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_196970 V1231882 LPXD map00540,map01100 M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) COG1044 Cluster_107637 V1231883 LPXC map00061,map00540,map01100 M involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) COG0774 Cluster_315336 V1231884 LPXA map00540,map01100 M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) COG1043 Cluster_256449 V1231885 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_22278 V1231886 PONA map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_131897 V1231888 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_26369 V1231889 GLTA map00250,map00910,map01100,map01110,map01120,map01230 E glutamate synthase COG0543 Cluster_21142 V1231890 CLPC O ATP-dependent Clp protease, ATP-binding subunit ClpC COG0542 Cluster_269751 V1231891 RFBD map00521,map00523,map01100,map01110 M Dtdp-4-dehydrorhamnose reductase COG1091 Cluster_412515 V1231892 S NA 11MP2 Cluster_368646 V1231893 S Lysine exporter protein (Lyse ygga) 11GJN Cluster_224340 V1231894 GLK map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G glucokinase COG1940 Cluster_58039 V1231895 P Voltage gated chloride channel COG0038 Cluster_427117 V1231896 J sua5 ycio yrdc ywlc family protein COG0009 Cluster_589334 V1231897 GLF M udp-galactopyranose mutase COG0562 Cluster_189888 V1231898 map00051,map00520,map01100 M RmlD substrate binding domain COG1089 Cluster_715015 V1231899 HOL S holin, phage phi LC3 family COG5546 Cluster_49583 V1231903 M Minor structural protein 0XPF3 Cluster_341022 V1231904 S phage tail component 0Z5R7 Cluster_43322 V1231905 S tail tape measure protein COG5280 Cluster_523209 V1231907 YBCS S lysozyme COG3772 Cluster_396579 V1231909 S NA 0Z2K9 Cluster_87263 V1231910 S NA 11QZ9 Cluster_4761 V1231911 S NA 0Z4Z7 Cluster_34355 V1231913 S NA 11VK0 Cluster_332062 V1231915 FTSE map02010 D Cell division ATP-binding protein ftsE COG2884 Cluster_509926 V1231916 L transposase 11HFY Cluster_517880 V1231917 S NA 0Y8F7 Cluster_91382 V1231918 S NA 0XT33 Cluster_7652 V1231919 S NA 0XRT1 Cluster_502347 V1231922 BCP O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG1225 Cluster_177793 V1231923 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_307878 V1231924 SP_1668 S TIGR02206 family 11T9J Cluster_291302 V1231925 map00630,map01100,map01110 S Phosphoglycolate Phosphatase COG0546 Cluster_208361 V1231928 HOLA map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii, delta' subunit COG1466 Cluster_515203 V1231929 V type I restriction enzyme 11IAT Cluster_285941 V1231930 S Zinc ribbon domain protein 0YJTX Cluster_306569 V1231931 S NIF3 (NGG1p interacting factor 3) COG0327 Cluster_255214 V1231932 NUCA map04210 F DNA RNA NON-specific endonuclease COG1864 Cluster_319927 V1231933 YBBM S ABC transporter, permease COG0390 Cluster_116293 V1231935 F Uracil permease COG2233 Cluster_3889 V1231937 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_606883 V1231938 S Inherit from NOG: Pfam:DUF88 0XSP1 Cluster_724929 V1231939 S NA 0YUPP Cluster_460954 V1231940 U TraG family COG3505 Cluster_90426 V1231941 U TraG family COG3505 Cluster_145720 V1231942 S Relaxase mobilization nuclease 0Y9PG Cluster_610540 V1231943 S NA 11WI9 Cluster_309292 V1231944 D ATPase MipZ 0ZR7H Cluster_534480 V1231945 S Protein of unknown function (DUF3408) 11HMK Cluster_589335 V1231946 S Protein of unknown function (DUF3408) 1225U Cluster_330499 V1231948 D Chromosome partitioning 11HPB Cluster_82124 V1231950 M Polysaccharide Biosynthesis Protein 0XP95 Cluster_225513 V1231951 M transferase family 2 COG0463 Cluster_85540 V1231954 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_94694 V1231955 V Mate efflux family protein COG0534 Cluster_70541 V1231956 HSDM V type I restriction-modification system COG0286 Cluster_405408 V1231958 CADD P cadmium resistance COG4300 Cluster_141995 V1231962 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_99492 V1231963 S ATPase AAA superfamily 0XSDB Cluster_715016 V1231965 S phage protein 124IT Cluster_245168 V1231966 S NA 0XXAQ Cluster_295449 V1231969 map00500,map01100,map01110 G synthase COG0297 Cluster_661359 V1231970 S domain protein 0YF83 Cluster_318442 V1231971 V Type II site-specific deoxyribonuclease 0ZIH9 Cluster_705395 V1231972 S conserved domain protein 11G4D Cluster_101701 V1231975 S NA 11QZ9 Cluster_119894 V1231976 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_338140 V1231979 S zinc metalloprotease COG1451 Cluster_68900 V1231980 S ErfK YbiS YcfS YnhG COG1376 Cluster_172887 V1231981 map02010 P extracellular solute-binding protein COG1840 Cluster_28068 V1231982 S Protein of unknown function (DUF524) COG1700 Cluster_47112 V1231983 V ATPase associated with various cellular activities aaa_5 COG1401 Cluster_625397 V1231985 K Transcriptional regulator COG0789 Cluster_310736 V1231987 V Type II restriction 11GYI Cluster_205057 V1231988 L DNA methylase n-4 n-6 domain protein COG2189 Cluster_7350 V1231989 RECG map03420,map03440 L transcriptioN-repair coupling factor COG1197 Cluster_21850 V1231991 XYLS map00052,map00500,map01100 G hydrolase, family 31 COG1501 Cluster_249064 V1231996 S NA 0Z3KR Cluster_342548 V1231998 CDPW8_0150 K Antirepressor COG3645 Cluster_551944 V1232001 map03060,map03070 S Preprotein translocase subunit SecB 0ZZSK Cluster_440989 V1232003 S NA 11ZXQ Cluster_509927 V1232004 S NA 125HA Cluster_114214 V1232009 S transporter gate domain protein 0XRV8 Cluster_112770 V1232010 AGCS E amino acid carrier protein COG1115 Cluster_213825 V1232011 TRAJ S conjugative transposon 0XP5P Cluster_303680 V1232012 YBHL S Membrane COG0670 Cluster_797022 V1232013 S NA 0YSBG Cluster_20681 V1232022 S NA 0XPM9 Cluster_38993 V1232023 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_563766 V1232024 HIT F, G Histidine triad (HIT) protein COG0537 Cluster_447024 V1232025 S Possible lysine decarboxylase COG1611 Cluster_367035 V1232026 S Plasmid pRiA4b ORF-3 family protein 11TVE Cluster_143473 V1232028 S NA 0Y00S Cluster_427118 V1232029 O AhpC TSA family COG0526 Cluster_166153 V1232030 CZCB P Efflux transporter rnd family, mfp subunit 0XR5J Cluster_194426 V1232031 G Alpha-1,2-mannosidase COG3537 Cluster_537370 V1232032 G Alpha-1,2-mannosidase COG3537 Cluster_718265 V1232033 CUSR map02020 T Trans_reg_C COG0745 Cluster_272389 V1232034 OCAR_7318 map02030,map02040 N Ompa motb domain protein COG1360 Cluster_227773 V1232035 S PAP2 superfamily domain protein 11HHM Cluster_217339 V1232036 map00052,map00520,map01100,map01110 G, M epimerase COG0451 Cluster_32567 V1232037 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_523210 V1232038 CPIN_3686 L Transposase (IS4 family COG3385 Cluster_287345 V1232039 RECT L recT protein COG3723 Cluster_531696 V1232043 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_104603 V1232047 AMET_0415 S phage protein 0Y97T Cluster_566961 V1232048 LGAS_0606 S Phage Portal Protein 0XP33 Cluster_619 V1232049 S NA 0YZ82 Cluster_163693 V1232051 GSIA map02010 E, P ABC transporter COG0444 Cluster_573247 V1232056 S NA 0Y578 Cluster_305182 V1232058 O ADP-ribosylglycohydrolase COG1397 Cluster_47113 V1232059 NAGH map00051,map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 G hydrolase family 20, catalytic COG3525 Cluster_220816 V1232060 DUSB J Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_563767 V1232061 S Thioesterase 11QVX Cluster_128183 V1232062 S Protein of unknown function (DUF2851) 0XPBG Cluster_117718 V1232063 MIAB J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) COG0621 Cluster_9093 V1232064 HSDR V Type I Restriction COG0610 Cluster_196160 V1232065 C Alcohol dehydrogenase zinc-binding domain protein COG1063 Cluster_259053 V1232066 S Methyltransferase 11REP Cluster_231274 V1232068 map02010 E (ABC) transporter COG4608 Cluster_56248 V1232069 CYDC map02010 V ABC transporter COG1132 Cluster_305183 V1232070 MRAZ S Cell division protein mraZ COG2001 Cluster_12834 V1232071 L N-6 DNA Methylase 0XTBT Cluster_79482 V1232072 map00052,map00511,map00600,map01100 G Beta-galactosidase COG3250 Cluster_166154 V1232073 G glycosidase COG2152 Cluster_401814 V1232074 S O-methyltransferase-like protein 106VG Cluster_52363 V1232075 PEPD E Dipeptidase COG4690 Cluster_224341 V1232076 M 2 glycosyl transferase COG0463 Cluster_106418 V1232078 DINB2 L ImpB MucB SamB family protein COG0389 Cluster_25600 V1232080 BGAA map00052,map00511,map00600,map01100 G hydrolase, family 2 COG3250 Cluster_640992 V1232081 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG2852 Cluster_85541 V1232083 S sodium sulfate symporter 0YZKT Cluster_7013 V1232084 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_128184 V1232085 PGN_0948 S NA 0Z217 Cluster_614198 V1232088 S mobilization protein 11J0G Cluster_566962 V1232089 S Relaxase mobilization nuclease 0ZY81 Cluster_319928 V1232090 S NA 0ZX1V Cluster_224342 V1232091 S Caspase domain 0ZIUZ Cluster_586025 V1232092 S Inherit from NOG: MTH538 TIR-like domain (DUF1863) 11R8E Cluster_72163 V1232093 CCRB L Resolvase COG1961 Cluster_458900 V1232095 CPSO M Glycosyl Transferase COG0463 Cluster_287346 V1232096 S NIF3 (NGG1p interacting factor 3) COG0327 Cluster_231275 V1232097 NANA map00300,map00520,map01100,map01110,map01120,map01230 E dihydrodipicolinate COG0329 Cluster_302229 V1232099 Q methyltransferase COG0500 Cluster_60143 V1232100 PGN_0949 V ABC transporter, ATP-binding protein COG1132 Cluster_502348 V1232102 S NA 11JHF Cluster_90427 V1232103 HTRA map02020,map03010 M serine protease COG0265 Cluster_246489 V1232104 RPOS map05111 K RNA polymerase COG0568 Cluster_599683 V1232105 S NA 0YEME Cluster_66860 V1232106 S Pap2 superfamily protein 0YA89 Cluster_80585 V1232107 L Recombinase COG1961 Cluster_452962 V1232108 S -acetyltransferase 11PF0 Cluster_114215 V1232109 KTRB P Potassium uptake protein COG0168 Cluster_302230 V1232110 M cell wall hydrolase autolysin COG5263 Cluster_156958 V1232111 VIRE2 S Virulence-associated protein e COG5545 Cluster_341023 V1232113 L Transposase COG3464 Cluster_42954 V1232120 RLMC map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) COG2265 Cluster_17708 V1232121 ADHE map00010,map00051,map00071,map00350,map00362,map00363,map00591,map00620,map00621,map00622,map00625,map00626,map00650,map01100,map01110,map01120 C Dehydrogenase COG1454 Cluster_371969 V1232122 map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_32310 V1232123 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_89513 V1232124 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_180330 V1232125 YQHQ J Metal-dependent enzyme COG3872 Cluster_1136 V1232126 S NA 101UU Cluster_400033 V1232128 BMUL_5533 S NA 0XPT9 Cluster_12753 V1232129 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_429015 V1232130 S NA 0Z7BG Cluster_3442 V1232133 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_797024 V1232134 S helix-turn-helix domain protein 122WR Cluster_89514 V1232136 S ATP-binding region, ATPase domain protein 0XPQ5 Cluster_14401 V1232137 S Endonuclease 0XNXZ Cluster_614199 V1232138 CAS2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) COG3512 Cluster_9910 V1232141 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_180331 V1232142 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_477978 V1232143 ALAR K transcriptional regulator AsnC family COG1522 Cluster_236100 V1232144 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_17810 V1232145 CBIO map02010 P ABC transporter COG1122 Cluster_227774 V1232146 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_300844 V1232149 S domain protein 0Y19Z Cluster_477979 V1232151 BMUR_1332 S Domain of Unknown Function (DUF1599) 0XXR0 Cluster_442994 V1232153 map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_38136 V1232160 S NA 0XQYE Cluster_103428 V1232161 SGLY_0562 S NA 0ZU6E Cluster_74816 V1232162 S NA 12ATZ Cluster_114216 V1232163 map02020 T Histidine kinase COG0642 Cluster_1352 V1232165 L helicase COG4646 Cluster_80166 V1232167 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_280377 V1232168 S Protein of unknown function (DUF3737) 0XTHF Cluster_190750 V1232169 MENE map00130,map01100,map01110 H o-succinylbenzoic acid-CoA ligase COG0318 Cluster_196971 V1232170 MENF map00130,map01053,map01100,map01110 H Isochorismate synthase COG1169 Cluster_164494 V1232171 ISPE map00900,map01100,map01110 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COG1947 Cluster_109432 V1232175 LYTS map02020 T Histidine kinase COG3275 Cluster_168537 V1232176 S NA 11EME Cluster_106419 V1232177 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_49584 V1232178 ATPA map00190,map00195,map01100,map04610,map05202 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_1521 V1232179 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_67527 V1232180 MOD L DNA methylase COG2189 Cluster_31615 V1232181 V Type III restriction enzyme, res subunit 0ZVEA Cluster_259054 V1232182 S ATP-dependent endonuclease of the OLD family-like protein 16SPZ@proNOG Cluster_241163 V1232183 CYNR K Transcriptional regulator 0ZWMP Cluster_100563 V1232184 S integral membrane protein 0XS1S Cluster_66579 V1232185 YIDE P transport protein COG2985 Cluster_279073 V1232186 TRMD map00900,map01100,map01110 J Specifically methylates guanosine-37 in various tRNAs (By similarity) COG0336 Cluster_44836 V1232188 map00071,map01100,map03320,map04146,map04920 I AMP-dependent synthetase and ligase COG1022 Cluster_34636 V1232189 S conjugation system ATPase, TraG family 0XSHU Cluster_867936 V1232190 S conjugation system ATPase, TraG family 0XSHU Cluster_391163 V1232191 TRAI S Conjugative transposon protein TraI 0ZVHG Cluster_189889 V1232192 TRAJ S conjugative transposon 0XP5P Cluster_394799 V1232193 S NA 0YBND Cluster_327607 V1232194 TRAM S Conjugative transposon TraM protein 0XQI8 Cluster_162054 V1232195 THII map00730,map01100,map04122 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) COG0301 Cluster_171974 V1232196 IDSA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_180332 V1232199 V type I restriction enzyme COG4748 Cluster_526120 V1232201 S secretion activator protein COG3926 Cluster_35571 V1232202 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_499810 V1232203 QUEF map00790,map01100 S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) COG0780 Cluster_357099 V1232204 S Membrane COG1738 Cluster_186485 V1232205 O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG0526 Cluster_49968 V1232206 map02020 T Histidine kinase 0XNMH Cluster_352072 V1232207 T Two component transcriptional regulator, winged helix family COG0745 Cluster_355407 V1232209 TRAA map03440 L mobA MobL family protein COG0507 Cluster_276410 V1232210 S NA 0Z08G Cluster_207239 V1232212 CRR map00010,map00500,map00520,map02060 G Pts system COG2190 Cluster_50574 V1232216 map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_163694 V1232217 S NA 0XTII Cluster_26577 V1232219 V Type I restriction-modification system R subunit COG4096 Cluster_93300 V1232220 HSDM V Type I restriction-modification system, M subunit COG0286 Cluster_79483 V1232221 S Vitamin K epoxide reductase 11HU3 Cluster_321407 V1232222 S NA 11KAE Cluster_170333 V1232224 map00051 M group 1 family protein 0ZJV3 Cluster_398297 V1232225 S Lanthionine synthetase C-like protein 11ZHE Cluster_8048 V1232226 L DNA helicase COG1112 Cluster_499811 V1232227 GUAD map00230,map01100 F, J deaminase COG0590 Cluster_217340 V1232228 S 5 nucleotidase deoxy cytosolic type C 11SZB Cluster_103429 V1232230 MALF map02010 P permease protein COG1175 Cluster_42598 V1232231 PULA G Glycogen debranching enzyme COG1523 Cluster_19449 V1232233 L helicase COG4646 Cluster_212702 V1232236 S NA 11YT1 Cluster_138994 V1232239 K Transcriptional regulator COG3604 Cluster_502349 V1232240 S NA 11RX2 Cluster_324551 V1232241 S NA 11PBC Cluster_96293 V1232242 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_50161 V1232243 M Sulfatase COG1368 Cluster_69261 V1232244 YIDE P transport protein COG2985 Cluster_355408 V1232245 S sporulation and cell division repeat protein 12AK5 Cluster_27183 V1232246 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_15320 V1232247 CTPE P ATPase, P-type (Transporting), HAD superfamily, subfamily IC COG0474 Cluster_171975 V1232248 T Histidine kinase COG5000 Cluster_454981 V1232249 K Inherit from COG: Transcriptional regulator COG3655 Cluster_6061 V1232251 S atp-dependent nuclease subunit 11HAW Cluster_250320 V1232252 ISPD map00900,map01100,map01110 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COG1211 Cluster_91866 V1232253 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_341024 V1232254 S Pfam:DUF901 11XWA Cluster_32851 V1232256 S peptidase C10 11SDT Cluster_91867 V1232257 RNY S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 Cluster_341025 V1232258 RECX S regulatory protein RecX 125BK Cluster_2185 V1232264 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_378851 V1232265 COMM O Mg chelatase subunit ChlI COG0606 Cluster_517881 V1232266 S Pfam:DUF156 COG1937 Cluster_31299 V1232267 L phage plasmid primase, p4 family COG3378 Cluster_785270 V1232268 K, L domain protein COG0553 Cluster_277711 V1232272 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0847 Cluster_596169 V1232274 FUCP G glucose galactose transporter COG0738 Cluster_72484 V1232275 COMM O Mg chelatase subunit ChlI COG0606 Cluster_2289 V1232276 U, W Pfam:YadA COG5295 Cluster_163695 V1232277 SUFB O SufB sufD domain protein COG0719 Cluster_254010 V1232278 NANH map00520 E, M N-acetylneuraminate lyase COG0329 Cluster_551945 V1232279 MIDI_00056 L Transposase 0YEAS Cluster_708500 V1232280 L transposase COG2826 Cluster_570049 V1232281 INSI L transposase COG2826 Cluster_82545 V1232283 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_332063 V1232284 BMUL_0586 map00051,map00520,map01100,map01110 M Nucleotidyl transferase COG1208 Cluster_80972 V1232285 S Phosphotransferase enzyme family COG3178 Cluster_526121 V1232286 S NA 0YYZU Cluster_403591 V1232290 MURE map00300,map00550,map01100 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_385897 V1232291 SCPB K Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) COG1386 Cluster_36265 V1232292 RPSA map00900,map01100,map01110,map03010 J Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) COG0761 Cluster_242538 V1232294 PGN_0049 S Antirestriction protein COG4734 Cluster_318443 V1232302 BCRA map02010 V ABC, transporter COG1131 Cluster_596170 V1232303 M efflux transporter, outer membrane factor lipoprotein, NodT family COG1538 Cluster_640993 V1232304 CYCMA_0607 S transposase 11H93 Cluster_55246 V1232307 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_130342 V1232308 LEPB map03060 U Signal peptidase i COG0681 Cluster_85542 V1232309 MALQ map00500,map01100 G 4-alpha-glucanotransferase (EC 2.4.1.25) COG1640 Cluster_347345 V1232311 S NA 11XKH Cluster_116294 V1232312 E, G Gluconate COG2610 Cluster_189890 V1232314 map02020 T Histidine kinase COG0642 Cluster_96294 V1232317 S Terminase, large subunit 0Z5IJ Cluster_546008 V1232319 S NA 0YIEB Cluster_50575 V1232320 ECFA1 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_11368 V1232321 M Glycosyl transferase, family 2 0XPRU Cluster_268412 V1232324 S NA 11SFQ Cluster_110744 V1232326 C oxidoreductase nitrogenase component 1 COG2710 Cluster_72485 V1232327 S NA 11GMQ Cluster_215007 V1232328 S mobilization protein 0XWI1 Cluster_576480 V1232331 CZRA K Transcriptional regulator, arsr family COG0640 Cluster_114217 V1232333 S Protein of unknown function (DUF3071) 102GP Cluster_277712 V1232335 LIPA map00785,map01100 H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) COG0320 Cluster_310737 V1232337 S NA 1280H Cluster_523212 V1232338 map03440 K Transcriptional regulator COG2865 Cluster_708501 V1232339 GROS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) COG0234 Cluster_800952 V1232340 S helix-turn-helix domain protein 122WR Cluster_50364 V1232341 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_820765 V1232342 NMB1132 S T5orf172 domain 10WZH Cluster_785271 V1232343 DIND S DNA-damage-inducible protein d 0XQQP Cluster_400034 V1232344 TRAM S Conjugative transposon TraM protein 0XQI8 Cluster_247747 V1232345 S Conjugative transposon TraN protein 0XNQ2 Cluster_417969 V1232346 S conjugative transposon protein TraO 0YYJU Cluster_280378 V1232347 L DNA primase 11GUV Cluster_504754 V1232348 S conjugative transposon protein TraQ 11SF8 Cluster_467233 V1232349 PGN_0055 S NA 11YX6 Cluster_255215 V1232350 M glycosyltransferase group 2 family protein COG0463 Cluster_54030 V1232351 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_180333 V1232354 LIGA map03410,map03420,map03430,map03450 L DNA ligase COG1793 Cluster_139784 V1232362 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_213826 V1232363 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_367036 V1232364 LICD M licD family COG3475 Cluster_350570 V1232365 RLUC J pseudouridine synthase COG0564 Cluster_489658 V1232366 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_360438 V1232367 S Acetyltransferase (GNAT) family 0ZX5P Cluster_502350 V1232368 J gCN5-related N-acetyltransferase COG1670 Cluster_748143 V1232369 K Pfam:AraC_E_bind COG3708 Cluster_398298 V1232370 Q Methyltransferase COG0500 Cluster_265686 V1232371 S NA 0Z2J2 Cluster_72825 V1232372 BL01928 O AAA ATPase, central domain protein COG0464 Cluster_86383 V1232373 S NA 0YNK8 Cluster_108187 V1232374 P Transporter COG0733 Cluster_741489 V1232375 S Hydrolase COG0561 Cluster_132650 V1232376 S NA 0YESD Cluster_58796 V1232377 map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 G Glycosyl hydrolase family 20, catalytic domain protein COG3525 Cluster_265687 V1232379 S Methyltransferase domain protein 11HQ9 Cluster_224343 V1232380 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_50162 V1232381 M Minor structural protein 0XPF3 Cluster_341026 V1232382 S phage tail component 0Z5R7 Cluster_96813 V1232383 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_149590 V1232385 map00500,map01100 N Alpha-L-fucosidase 0XPGV Cluster_400035 V1232386 V restriction COG0732 Cluster_648938 V1232387 HSDM L N-6 DNA methylase COG0286 Cluster_193487 V1232388 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_19377 V1232389 DNAQ map03420,map03430 L Uvrd rep helicase COG2176 Cluster_183809 V1232390 CLCAR_0885 S VWA-like domain (DUF2201) COG3864 Cluster_55990 V1232391 PRKC T serine threonine protein kinase COG0515 Cluster_3955 V1232392 U, W Pfam:YadA COG5295 Cluster_32080 V1232393 S NA 0XT1C Cluster_431002 V1232394 S NA 11KIH Cluster_748144 V1232395 CLOSA_0730 V Hnh endonuclease COG1479 Cluster_142774 V1232397 map02010 M abc transporter permease protein COG4591 Cluster_90428 V1232398 S NA 12185 Cluster_79793 V1232399 PRFC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) COG4108 Cluster_449049 V1232400 RPLI map03010 J Binds to the 23S rRNA (By similarity) COG0359 Cluster_721587 V1232401 RPSR map03010 J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) COG0238 Cluster_625401 V1232402 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_156109 V1232403 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_442995 V1232404 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_355409 V1232405 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_85917 V1232406 M Sulfatase COG1368 Cluster_275078 V1232407 FOLP map00790,map01100 H dihydropteroate synthase COG0294 Cluster_39479 V1232410 S Protein of unknown function (DUF1524) COG1479 Cluster_221984 V1232411 S NA 0YF1V Cluster_485022 V1232412 RIMM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) COG0806 Cluster_789274 V1232414 DACET_0688 L Transposase COG3328 Cluster_194427 V1232415 AGUA map00330,map01100 E Agmatine deiminase COG2957 Cluster_91868 V1232417 U TraG family COG3505 Cluster_47494 V1232418 LKTB3 V ABC transporter, ATP-binding protein COG2274 Cluster_38494 V1232419 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii subunits gamma and tau COG2812 Cluster_27692 V1232420 P tonB-dependent Receptor 0XQ03 Cluster_401815 V1232421 RECR map03440 L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) COG0353 Cluster_155297 V1232422 WBBL M Glycosyl transferase, family 2 COG1216 Cluster_439001 V1232423 SPEG map00330,map01100 J acetyltransferase, (GNAT) family COG1670 Cluster_266999 V1232424 THID map00730,map00750,map01100 H phosphomethylpyrimidine kinase COG0351 Cluster_813175 V1232430 K Phage regulatory protein rha COG3646 Cluster_549056 V1232433 S filamentation induced by cAMP protein Fic COG3177 Cluster_102264 V1232434 S domain protein 0YF83 Cluster_77128 V1232435 T FHA Domain-Containing protein 0ZXYF Cluster_224344 V1232439 G Xylose Isomerase Domain-Containing protein 11IHC Cluster_87265 V1232442 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_589336 V1232443 I Phosphoesterase, PA-phosphatase related COG0671 Cluster_42599 V1232444 map02020 T Histidine kinase COG2972 Cluster_126103 V1232446 ZNUA map02010 P transporter substrate-binding protein COG0803 Cluster_74817 V1232447 L Reverse transcriptase (RNA-dependent DNA polymerase) COG3344 Cluster_259055 V1232451 THIM map00730,map01100 H 4-methyl-5-beta-hydroxyethylthiazole kinase COG2145 Cluster_59347 V1232458 map00051 M glycosyl transferase group 1 11STI Cluster_473632 V1232460 S NA 17IU1@proNOG Cluster_88119 V1232461 BVU_0431 L resolvase domain protein COG1961 Cluster_48320 V1232463 TRAG2 S conjugation system ATPase, TraG family 0XSHU Cluster_391164 V1232464 TRAI S Conjugative transposon protein TraI 0YE08 Cluster_201890 V1232465 TRAJ S conjugative transposon 0XP5P Cluster_109433 V1232466 V Mate efflux family protein COG0534 Cluster_748145 V1232468 ATPE map00190,map00195,map01100 C atp synthase 124UB Cluster_29304 V1232471 COMEC S ComEC rec2-like protein COG0658 Cluster_165341 V1232472 GLXK map00260,map00561,map00630,map01100,map01110 G Glycerate kinase COG1929 Cluster_576481 V1232474 YTFP S hi0933 family COG2081 Cluster_42418 V1232475 V ATPase associated with various cellular activities aaa_5 COG1401 Cluster_657147 V1232476 S DNA-binding protein COG3943 Cluster_196972 V1232478 TSNR J rrna methyltransferase COG0566 Cluster_37327 V1232483 DXS map00730,map00900,map01100,map01110 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) COG1154 Cluster_283121 V1232484 G 4-alpha-glucanotransferase COG1640 Cluster_465155 V1232485 RPSG map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) COG0049 Cluster_322972 V1232486 FABG5 map00061,map00780,map01040,map01100 I, Q reductase COG1028 Cluster_711632 V1232487 L Integrase core domain protein COG2801 Cluster_230101 V1232488 S NA 0YDZN Cluster_576482 V1232491 S NA 0ZNRV Cluster_102802 V1232492 HEXOKINASE map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map04066,map04910,map04930,map04973 G hexokinase COG5026 Cluster_197904 V1232493 S NA 11F7I Cluster_669851 V1232494 S NA 0Y25P Cluster_67528 V1232497 NODB G Deacetylase COG0726 Cluster_188184 V1232498 S AAA domain (dynein-related subfamily) COG0714 Cluster_687663 V1232499 L NA 0YKV1 Cluster_400037 V1232504 L DNA alkylation repair enzyme 0YG23 Cluster_176139 V1232506 ELI_1297 O phage portal protein HK97 family COG4695 Cluster_71518 V1232507 OCAR_6158 L Terminase, large subunit COG4626 Cluster_95706 V1232508 MIAB J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) COG0621 Cluster_7379 V1232509 L adenine specific DNA methyltransferase COG4889 Cluster_582832 V1232510 S NA 0YIA5 Cluster_7423 V1232512 map00511,map04142 G beta-mannosidase EC 3.2.1.25 COG3250 Cluster_507338 V1232516 S Protein of unknown function (DUF3408) 11QAR Cluster_245169 V1232517 S relaxase mobilization nuclease domain protein 0XNXG Cluster_296790 V1232520 S NA 0ZBRU Cluster_57770 V1232521 MUTS2 L DNA mismatch repair protein COG0249 Cluster_8681 V1232524 S Phage tail tape measure protein, TP901 family 10QPB Cluster_15103 V1232525 S NA 0ZTYV Cluster_339570 V1232527 YLXR K Nucleic-acid-binding protein implicated in transcription termination COG2740 Cluster_773686 V1232530 S NA 0Y3C9 Cluster_871873 V1232531 S helix-turn-helix domain protein 122WR Cluster_198899 V1232532 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_373592 V1232534 ISPF map00900,map01100,map01110 I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) COG0245 Cluster_41220 V1232536 S Uncharacterized conserved protein (DUF2075) 0XPB6 Cluster_431003 V1232537 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_187323 V1232540 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_35834 V1232542 S abortive phage infection 0XQE9 Cluster_30353 V1232543 PFLB map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_236101 V1232544 DGT map00230 F deoxyguanosinetriphosphate triphosphohydrolase-like protein COG0232 Cluster_407078 V1232545 EA59 S EA59 protein 0XSHM Cluster_232440 V1232546 S NA 17TQC@proNOG Cluster_90429 V1232547 map03440 K Transcriptional regulator COG2865 Cluster_39150 V1232550 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_407079 V1232551 S NA 0Y2UG Cluster_414390 V1232552 V restriction modification system DNA specificity COG0732 Cluster_133484 V1232553 S NA 0YVMU Cluster_440990 V1232554 S NA 122KH Cluster_98967 V1232557 YIHY S ribonuclease bn COG1295 Cluster_249065 V1232558 PATATIN S Phospholipase, patatin family COG1752 Cluster_40072 V1232559 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_9028 V1232561 HSDR V Type I Restriction COG0610 Cluster_69610 V1232564 PRC M Peptidase, S41 family COG0793 Cluster_721588 V1232565 L NA 11GDS Cluster_475784 V1232567 COMEC S ComEC rec2-like protein COG0658 Cluster_606884 V1232568 RFBC map00521,map00523,map01100,map01110 M Dtdp-4-dehydrorhamnose 3,5-epimerase COG1898 Cluster_338141 V1232570 OA238_1743 L transposase COG3436 Cluster_537371 V1232571 OA238_1743 L transposase COG3436 Cluster_326046 V1232572 H thiF family COG0476 Cluster_391165 V1232573 K Transcriptional Regulator, LuxR family 0Y1WM Cluster_344132 V1232576 map00780,map01100 S Protein of unknown function (DUF452) COG2830 Cluster_313755 V1232577 BIOC map00780,map01100 H Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) 11P8N Cluster_74490 V1232578 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_341027 V1232579 GLDL S gliding motility-associated protein GldL 0XPKJ Cluster_219630 V1232580 SRTB U sortase, SrtB family COG4509 Cluster_176958 V1232581 M polysaccharide deacetylase COG0726 Cluster_19289 V1232583 S NA 0YZ82 Cluster_185567 V1232584 BMUL_2277 L DNA Methylase COG1475 Cluster_60653 V1232585 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_695954 V1232586 S virulence-like protein 0ZW8F Cluster_43893 V1232587 S Inherit from NOG: domain protein 0XXVB Cluster_711633 V1232589 U type II secretion system protein 0XYZS Cluster_300845 V1232590 SURE map00230,map00240,map00760,map01100,map01110 F Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) COG0496 Cluster_702305 V1232591 V type iii restriction 0ZVEY Cluster_264357 V1232594 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_177795 V1232595 S Virulence-associated protein e COG5545 Cluster_43490 V1232596 MALL map00052,map00500,map01100 G trehalose-6-phosphate hydrolase (EC 3.2.1.93) COG0366 Cluster_72486 V1232599 S VirE N-terminal domain 11VR1 Cluster_268413 V1232601 SPEB map00330,map00340,map01100 E agmatinase COG0010 Cluster_122160 V1232602 L Integrase 0YTFQ Cluster_546009 V1232603 S NA 0YIEB Cluster_75469 V1232604 S NA 1278K Cluster_629113 V1232605 S mobilization protein 11J0G Cluster_172888 V1232606 VIRE L Virulence-associated protein e COG5545 Cluster_603261 V1232607 S NA 122EK Cluster_741490 V1232608 L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) COG0582 Cluster_213827 V1232610 S Uncharacterized protein conserved in bacteria (DUF2179) COG1284 Cluster_212703 V1232611 S NA 0ZBRU Cluster_12566 V1232612 S NA 0YZ82 Cluster_705399 V1232613 S kila-n, DNA-binding domain 0XPNQ Cluster_200894 V1232614 S NA 11KCE Cluster_215008 V1232615 DPPD E, P (ABC) transporter COG0444 Cluster_610544 V1232616 S NA 0YIEB Cluster_336593 V1232618 S Transcription termination factor nusG 0YBKK Cluster_347346 V1232620 YUIF S Na H antiporter COG2056 Cluster_793070 V1232625 RC1_2786 L transposase COG5433 Cluster_423396 V1232626 S NA 11XZH Cluster_11755 V1232627 L helicase COG4646 Cluster_80973 V1232628 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_299471 V1232629 S NA 11QPY Cluster_134274 V1232630 GLGC map00500,map00520,map01100,map01110 G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) COG0448 Cluster_329101 V1232631 map02010 V ABC transporter COG1131 Cluster_502351 V1232634 T Two component transcriptional regulator (Winged helix family COG0745 Cluster_509928 V1232636 S NA 0YRIH Cluster_178633 V1232639 S NA 11EJC Cluster_254011 V1232640 map00230,map00240,map01100,map03030,map03430,map03440 L EXOIII COG2176 Cluster_209406 V1232644 RIHC map00230,map00240,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_156959 V1232645 TRAM S conjugative transposon 0YI63 Cluster_87266 V1232646 L helicase COG4646 Cluster_79794 V1232647 ASPC map00250,map00290,map01100,map01110,map01210,map01230 E Aminotransferase COG0436 Cluster_405409 V1232648 SCLAV_3916 U type ii secretion system protein e COG4962 Cluster_295450 V1232649 POTA map02010 E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COG3842 Cluster_73518 V1232650 S tonB-dependent Receptor 0YAYV Cluster_319929 V1232651 S radical SAM domain protein COG0641 Cluster_231276 V1232652 NFO map03410 L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) COG0648 Cluster_13212 V1232654 M outer membrane autotransporter barrel domain protein COG3468 Cluster_165342 V1232656 map00051,map00363,map00591,map00625,map00650,map01100,map01120 C alcohol dehydrogenase COG1979 Cluster_295451 V1232657 map00680,map01120 S esterase COG0627 Cluster_384126 V1232659 S NA 0Y50Z Cluster_166155 V1232660 map00360 E amidohydrolase COG1473 Cluster_295452 V1232663 S Protein of unknown function (DUF2807) 0ZWQJ Cluster_341028 V1232664 S hi0933 family COG2081 Cluster_119131 V1232665 ELI_1297 O phage portal protein HK97 family COG4695 Cluster_14020 V1232668 M outer membrane autotransporter barrel domain protein COG3468 Cluster_789275 V1232672 S NA 0Z81S Cluster_380581 V1232673 RLML L Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) COG0116 Cluster_137481 V1232674 FTSW map04112 D cell division protein COG0772 Cluster_66580 V1232676 S NA 0Y12I Cluster_582833 V1232677 RPOD map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_348955 V1232680 K Zinc finger helix-turn-helix protein, YgiT family 11YS4 Cluster_451017 V1232681 S NA 0ZT2K Cluster_617957 V1232683 MUTY map03410 L a g-specific adenine glycosylase COG1194 Cluster_738083 V1232684 S Toxin-antitoxin system, antitoxin component, HicB family 11KI8 Cluster_27583 V1232686 U, W surface protein COG5295 Cluster_502352 V1232688 S phage protein 0Y5JY Cluster_98439 V1232689 P Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) COG4206 Cluster_371970 V1232690 THIN map00730,map01100 H thiamine COG1564 Cluster_417971 V1232691 PNUC H Nicotinamide Mononucleotide Transporter COG3201 Cluster_378853 V1232692 THIN map00730,map01100 H thiamine COG1564 Cluster_851809 V1232696 S NA 0YWQY Cluster_738084 V1232697 PGN_0051 S NA 0YP2S Cluster_353741 V1232698 PGN_0050 S NA 0XNWW Cluster_687664 V1232699 TNP3509A L Transposase for insertion sequence element 0Z3DP Cluster_236102 V1232701 S radical SAM domain protein 0Y14J Cluster_249066 V1232703 NANA map00300,map00520,map01100,map01110,map01120,map01230 E, M N-acetylneuraminate lyase COG0329 Cluster_157825 V1232704 map00520 G n-acylglucosamine 2-epimerase COG2942 Cluster_70242 V1232706 S NA 11YT1 Cluster_156960 V1232707 NORV map05132 C domain protein COG0426 Cluster_233705 V1232708 map00051,map00500,map00520,map01100 G kinase (PfkB family COG0524 Cluster_103430 V1232709 S DivIVA domain repeat protein 11XZ2 Cluster_307879 V1232710 S TonB family domain protein 0Y8AI Cluster_427119 V1232711 M Choline kinase COG4750 Cluster_230102 V1232712 BIOA map00780,map01100 H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) COG0161 Cluster_617958 V1232713 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_621623 V1232714 T FHA domain protein 11FQP Cluster_239892 V1232717 S NA 11HWJ Cluster_46355 V1232718 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_824752 V1232719 S NA 0Z9U6 Cluster_401816 V1232720 S NA 11VCX Cluster_692165 V1232721 S rRNA biogenesis protein Rrp5 0XUK3 Cluster_160387 V1232722 VIRE2 S Virulence-associated protein e COG5545 Cluster_145721 V1232724 BMUL_2277 L DNA Methylase COG1475 Cluster_105195 V1232725 UVRD map03420,map03430 L ATP-dependent DNA helicase pcra COG0210 Cluster_18863 V1232726 U, W Pfam:YadA COG5295 Cluster_44999 V1232727 YFGQ P ATPase, P-type (Transporting), HAD superfamily, subfamily IC COG0474 Cluster_112041 V1232728 BL00983 S Phage Portal Protein 11QNG Cluster_59889 V1232729 LPDA map00010,map00020,map00260,map00280,map00620,map01100,map01110,map01120 C dihydrolipoyl dehydrogenase COG1249 Cluster_145722 V1232730 L Integrase COG4974 Cluster_800954 V1232731 S helix-turn-helix domain protein 122WR Cluster_859591 V1232732 V N-6 DNA Methylase COG0286 Cluster_836187 V1232733 PS305 S Protein of unknown function (Hypoth_ymh) 10DNB Cluster_683240 V1232734 PS305 S Protein of unknown function (Hypoth_ymh) 10DNB Cluster_350572 V1232738 S amidohydrolase COG1574 Cluster_482703 V1232739 V Restriction modification system DNA (Specificity COG0732 Cluster_76426 V1232740 HSDS V restriction modification system DNA specificity domain COG0732 Cluster_504755 V1232741 DOC S Death-On-Curing Family 11N71 Cluster_482704 V1232742 RECX S regulatory protein RecX 11Y5X Cluster_640994 V1232743 L Integrase 0YTFQ Cluster_382353 V1232744 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_566964 V1232745 S HTH_XRE 0YHNY Cluster_184693 V1232749 DCM map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_888093 V1232750 S NA 11ISA Cluster_231277 V1232752 E, G Membrane COG0697 Cluster_352073 V1232753 BIOD map00780,map01100 H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) COG0132 Cluster_174526 V1232754 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_828566 V1232759 K Transcriptional regulator 0XUP9 Cluster_181160 V1232761 YCHF J gtp-binding protein COG0012 Cluster_551946 V1232762 S NA 0YZXZ Cluster_748148 V1232763 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_144974 V1232765 PPAC map00190 C Manganese-dependent inorganic pyrophosphatase COG1227 Cluster_21851 V1232766 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_576483 V1232770 S NA 0ZBRU Cluster_640995 V1232772 E Formiminotransferase-cyclodeaminase COG3404 Cluster_103431 V1232773 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG0469 Cluster_344133 V1232774 map00730,map01100 H thiamine COG1564 Cluster_132651 V1232775 FUCP G glucose galactose transporter COG0738 Cluster_416166 V1232776 S adenosylcobinamide amidohydrolase COG1865 Cluster_176140 V1232777 SUCC map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120 C Succinyl-CoA synthetase subunit beta COG0045 Cluster_265688 V1232778 SUCD map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120 C Succinyl-CoA ligase ADP-forming subunit alpha COG0074 Cluster_471530 V1232779 P Ferric uptake regulator family 11EP1 Cluster_414391 V1232780 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_543067 V1232781 S Membrane-bound lysozyme-inhibitor of c-type lysozyme 11EMY Cluster_636996 V1232782 S NA 0ZHU9 Cluster_273724 V1232783 S Filamentation induced by cAMP protein fic COG3177 Cluster_86823 V1232784 OCAR_6158 L Terminase, large subunit COG4626 Cluster_294038 V1232786 THID2 map00730,map00750,map01100 H Phosphomethylpyrimidine kinase COG0351 Cluster_82125 V1232787 S Pfam:YadA 0ZHSU Cluster_554837 V1232791 S NA 12BGZ Cluster_410706 V1232792 S Chap domain containing protein 0XP7Y Cluster_797025 V1232793 S Toprim domain protein 0ZC02 Cluster_636997 V1232794 S Toprim domain protein 0ZC02 Cluster_168538 V1232795 PG0695 M major outer membrane protein OmpA 11X18 Cluster_423397 V1232796 NADD map00230,map00760,map01100,map05340 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) COG1057 Cluster_444983 V1232799 F cytidine deoxycytidylate deaminase COG0295 Cluster_144975 V1232802 P hemerythrin hhe cation binding domain protein COG2461 Cluster_640996 V1232803 YTJA S Could be involved in insertion of integral membrane proteins into the membrane (By similarity) COG0759 Cluster_45170 V1232805 S NA 1278K Cluster_45171 V1232806 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_116295 V1232807 K, L domain protein COG0553 Cluster_540170 V1232808 S NA 11PZU Cluster_128185 V1232809 U TraG family COG3505 Cluster_702307 V1232812 HOL S holin, phage phi LC3 family COG5546 Cluster_296791 V1232813 S Chap domain containing protein 0XP7Y Cluster_259056 V1232814 L integrase family 0XRS7 Cluster_26674 V1232815 S NA 0ZTYV Cluster_485023 V1232816 S Domain of unknown function (DUF1896) 0YBI2 Cluster_452964 V1232818 K Transcriptional regulator 0XWJY Cluster_27272 V1232820 U, W Inherit from COG: domain protein COG5295 Cluster_708502 V1232821 S NA 18D0T@proNOG Cluster_134275 V1232822 S domain protein 0XPXI Cluster_380582 V1232824 NTH map03410 L endonuclease III COG0177 Cluster_350573 V1232825 GGT map00430,map00460,map00480,map00590,map01100 E gamma-glutamyltransferase COG0405 Cluster_108188 V1232826 S NA 11YT1 Cluster_315337 V1232827 K Transcriptional regulator COG1737 Cluster_400038 V1232828 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_526122 V1232829 S NA 11NFI Cluster_871876 V1232830 AASI_0454 S NA 0XPYJ Cluster_606885 V1232832 BMUL_2816 S Hypothetical protein (DUF2513) 17S32@proNOG Cluster_421538 V1232833 LGAS_0609 S Phage minor structural protein GP20 123J7 Cluster_171976 V1232834 LGAS_0607 T head morphogenesis protein, SPP1 gp7 COG5585 Cluster_166156 V1232835 LGAS_0606 S Phage Portal Protein 0XP33 Cluster_629114 V1232837 VIRE2 S Virulence-associated protein e COG5545 Cluster_724932 V1232838 L NA 0YKV1 Cluster_744791 V1232839 O sufB sufD domain protein COG0719 Cluster_554838 V1232840 AMIA M n-acetylmuramoyl-l-alanine amidase COG0860 Cluster_28766 V1232841 S NA 0YZ82 Cluster_454982 V1232842 ROCF map00330,map00340,map01100,map01110,map01230,map05146 E arginase EC 3.5.3.1 COG0010 Cluster_84285 V1232844 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_326047 V1232845 CUTC P copper homeostasis protein cutc COG3142 Cluster_36687 V1232846 M domain protein COG4932 Cluster_69611 V1232849 FADD map00071,map01100,map03320,map04146,map04920 I AMP-binding enzyme COG1022 Cluster_389431 V1232852 U TraG family COG3505 Cluster_208362 V1232854 YQAJ L phage-type endonuclease COG5377 Cluster_140517 V1232856 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_216145 V1232857 S NA 11YT1 Cluster_88576 V1232858 S Tail fiber protein 0ZQVQ Cluster_718266 V1232859 S NA 0XUY7 Cluster_339571 V1232860 BMUL_5920 S Rhomboid family COG0705 Cluster_137482 V1232863 L site-specific recombinase, phage integrase family 0ZJK4 Cluster_596172 V1232864 L integrase family 0ZJHZ Cluster_55000 V1232866 PORAS_0069 L Transposase (IS4 family 0XT1T Cluster_43706 V1232867 MOD map00340,map00350,map00624,map01120 L DNA methylase COG2189 Cluster_840072 V1232868 TMP1 S NA 10C99 Cluster_267001 V1232870 S NA 11EM0 Cluster_206137 V1232871 K Transcriptional regulator, LacI family COG1609 Cluster_296792 V1232873 VICX map03013 S domain protein COG1235 Cluster_546010 V1232875 RPLM map03010 J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) COG0102 Cluster_259057 V1232877 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_687665 V1232878 RAIA S ribosomal subunit Interface protein 124EG Cluster_104005 V1232879 FADD map00071,map01100,map03320,map04146,map04920 I Long-chain-fatty-acid--CoA ligase COG1022 Cluster_702308 V1232881 S NA 0ZHU9 Cluster_305184 V1232882 GLPR K Transcriptional regulator COG1349 Cluster_166157 V1232886 PURM map00230,map01100,map01110 F Phosphoribosylformylglycinamidine cyclo-ligase COG0150 Cluster_279074 V1232888 S NA 11ZMI Cluster_34356 V1232890 U, W Pfam:YadA COG5295 Cluster_131130 V1232891 L Site-specific recombinase, phage integrase family 11F8N Cluster_148825 V1232893 L integrase family 0XRS7 Cluster_373593 V1232894 SP_1381 V abc transporter atp-binding protein COG1131 Cluster_35307 V1232895 P tonB-dependent Receptor 0XNUH Cluster_144220 V1232896 S S-layer domain protein 11R54 Cluster_46143 V1232897 S SusD family 0XPTK Cluster_396580 V1232898 S Protein of unknown function (DUF1643) 11THT Cluster_213828 V1232900 S NA 11FB1 Cluster_96295 V1232901 P Natural resistance-associated macrophage protein COG1914 Cluster_206138 V1232902 U TraG family COG3505 Cluster_636998 V1232904 BMUL_2277 L DNA Methylase COG1475 Cluster_456925 V1232905 BMUL_2277 L DNA Methylase COG1475 Cluster_89515 V1232906 YJHA S Endonuclease Exonuclease phosphatase 0XNVA Cluster_36873 V1232907 map00500,map01100 G Glycogen debranching enzyme COG3408 Cluster_820766 V1232908 S NA 0YYZU Cluster_755016 V1232909 S YitT family COG1284 Cluster_403592 V1232910 map00540,map01100 S Phage-related protein 11PAV Cluster_576484 V1232911 CKL_1904 S YopX protein 0XUQJ Cluster_37952 V1232913 S Phage tail tape measure protein, TP901 family 10QPB Cluster_813177 V1232914 S NA 0Y1FT Cluster_758544 V1232915 S NA 0Y83H Cluster_467234 V1232916 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_69612 V1232917 LAPB map02010 V ABC transporter COG2274 Cluster_540171 V1232919 L transposase COG2826 Cluster_387735 V1232920 S Vanz family 0XV9Q Cluster_557739 V1232922 S conjugative transposon 0YI63 Cluster_40865 V1232923 S NA 0YH2T Cluster_247749 V1232924 TRAN S Conjugative transposon TraN protein 0XNQ2 Cluster_46726 V1232926 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_473633 V1232927 S NA 0ZS73 Cluster_371971 V1232928 VIRE2 S Virulence-associated protein e COG5545 Cluster_683241 V1232929 L NA 0YKV1 Cluster_138995 V1232931 BL00759 L Phage terminase, large subunit COG1783 Cluster_699240 V1232932 S Protein of unknown function (DUF2874) 0ZF75 Cluster_427120 V1232933 Q Isochorismatase family COG1335 Cluster_371972 V1232934 S membrane protein involved in aromatic hydrocarbon degradation 0YMT5 Cluster_380583 V1232940 S NA 121T2 Cluster_439003 V1232943 BT_1821 L Transposase COG3385 Cluster_159545 V1232944 VICK T Histidine kinase 0XQQ4 Cluster_190751 V1232946 TRAM S conjugative transposon 0YI63 Cluster_96296 V1232947 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_271057 V1232949 SBCC L Exonuclease COG0419 Cluster_785275 V1232950 S NA 11ENH Cluster_355410 V1232951 S WD40-like beta Propeller containing protein 0YCAG Cluster_738085 V1232952 S NA 0YT0J Cluster_570050 V1232953 S NA 0YIA5 Cluster_797026 V1232955 CUTC P copper homeostasis protein cutc COG3142 Cluster_414392 V1232956 S integral membrane protein COG4243 Cluster_179504 V1232959 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_632944 V1232960 RPSK map03010 J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) COG0100 Cluster_54031 V1232961 P tonB-dependent receptor plug 0XSMW Cluster_185568 V1232962 PG0188 S BNR Asp-box repeat protein 11U9Y Cluster_53281 V1232963 BATD S BatD protein 0XR99 Cluster_115567 V1232964 S Family of unknown function (DUF490) 0Z0C5 Cluster_203975 V1232965 S Acyl-transferase COG3274 Cluster_79484 V1232968 RPRX map02020 T Histidine kinase COG5002 Cluster_198900 V1232969 S tail tape measure protein, TP901 family 0Y9J8 Cluster_65395 V1232970 MALL map00500,map01100 G Oligo-1-6-glucosidase COG0366 Cluster_546012 V1232971 S NA 0XR7N Cluster_797027 V1232972 S NA 0YBU3 Cluster_592695 V1232973 S NA 0YBU3 Cluster_692166 V1232974 S NA 120ZF Cluster_632945 V1232978 S conjugation system ATPase, TraG family 0XSHU Cluster_259058 V1232979 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0847 Cluster_492160 V1232980 S DNA-binding protein 0YGF9 Cluster_147291 V1232981 HSDS V Restriction modification system DNA (Specificity COG0732 Cluster_78112 V1232982 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_50163 V1232983 map05133 U hemagglutinin COG3210 Cluster_458901 V1232985 YDCK S acetyltransferase YdcK 175BH@proNOG Cluster_177796 V1232986 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_447025 V1232988 S NA 11EN6 Cluster_50958 V1232989 S NA 101UU Cluster_51327 V1232992 U, W Pfam:YadA COG5295 Cluster_748150 V1232993 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_537373 V1232994 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_378854 V1232995 RHAT10 E, G Membrane COG0697 Cluster_537374 V1232996 HEMD map00860,map01100,map01110 H uroporphyrinogeN-iii synthase 0XVP9 Cluster_512507 V1232997 S NA 0XV1Q Cluster_433000 V1232998 S NA 0ZRDA Cluster_442996 V1233002 map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_206139 V1233003 V restriction endonuclease COG3440 Cluster_582834 V1233004 S NA 0YIA5 Cluster_277713 V1233007 S Recombinase 0Y2JQ Cluster_385899 V1233009 CAS1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) COG1518 Cluster_540172 V1233010 CSD2 L CRISPR-Associated Protein COG3649 Cluster_148091 V1233013 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_728212 V1233014 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG0194 Cluster_333559 V1233015 S NA 0XQ5J Cluster_105811 V1233016 FLIC map02020,map02040,map04626,map05132,map05134 N Flagellin COG1344 Cluster_136691 V1233018 S Inherit from COG: ATPase (AAA COG1373 Cluster_259059 V1233019 S ABC transporter, ATP-binding protein COG0488 Cluster_165343 V1233020 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_909075 V1233021 CDD map00240,map00983,map01100,map05219 F cytidine deaminase COG0295 Cluster_336594 V1233022 DGKA map00561,map00564,map01100,map04070 M Diacylglycerol kinase COG0818 Cluster_147292 V1233023 DACF map00550,map01100 M carboxypeptidase COG1686 Cluster_148092 V1233024 GALK map00052,map00520,map01100,map01110 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) COG0153 Cluster_59890 V1233025 MAEB map00620,map00710,map01100,map01120 C Malic enzyme COG0281 Cluster_57771 V1233026 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_243889 V1233027 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_60962 V1233028 YFCC S c4-dicarboxylate anaerobic carrier COG1288 Cluster_820767 V1233029 NANA map00300,map00520,map01100,map01110,map01120,map01230 E dihydrodipicolinate COG0329 Cluster_573248 V1233031 VSAL_I0456 L Transposase COG3335 Cluster_497156 V1233032 M Glycosyl transferase (Group 1 COG0438 Cluster_344134 V1233034 S c4-dicarboxylate anaerobic carrier COG1288 Cluster_107638 V1233037 L Integrase 0YTFQ Cluster_250322 V1233038 S relaxase mobilization nuclease domain protein 0XNXG Cluster_592696 V1233039 S Pfam:DUF2825 1286S Cluster_648941 V1233042 RPLW map03010 J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) COG0089 Cluster_338143 V1233046 YQAJ L phage-type endonuclease COG5377 Cluster_554839 V1233047 S Endodeoxyribonuclease RusA 0XVTK Cluster_828567 V1233048 K anti-repressor COG3645 Cluster_62089 V1233050 U, W Pfam:YadA COG5295 Cluster_287347 V1233051 ISPG map00900,map01100,map01110 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) COG0821 Cluster_566965 V1233052 CSN1 L crispr-associated protein COG3513 Cluster_188185 V1233053 FCL map00051,map00520,map01100 M Nad-dependent epimerase dehydratase COG0451 Cluster_257736 V1233054 ISPG map00900,map01100,map01110 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) COG0821 Cluster_586028 V1233056 V HNH endonuclease COG1403 Cluster_515204 V1233057 S NA 11PZU Cluster_71236 V1233058 S NA 0Y80P Cluster_63748 V1233059 M RHS repeat-associated core domain protein COG3209 Cluster_64286 V1233062 S NA 0ZHVH Cluster_543069 V1233063 S NA 0YIA5 Cluster_353742 V1233065 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_237299 V1233066 LDH map00010,map00051,map00270,map00363,map00591,map00620,map00625,map00640,map00650,map01100,map01110,map01120 C L-lactate dehydrogenase COG0039 Cluster_614201 V1233067 HIT map00230,map00240 F, G histidine triad (hIT) protein COG0537 Cluster_734724 V1233068 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_184694 V1233070 YAAT S psp1 domain protein COG1774 Cluster_520440 V1233071 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG0582 Cluster_265689 V1233080 LYTR K TRANSCRIPTIONal COG1316 Cluster_219631 V1233082 SOV S Gliding motility-related protein 0XPT8 Cluster_797028 V1233083 S NA 128KH Cluster_69939 V1233085 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_231278 V1233086 RLUD J Pseudouridine synthase COG0564 Cluster_93301 V1233087 map00230,map00240,map00760,map01100,map01110 F 5'-nucleotidase COG0737 Cluster_586029 V1233088 RPMA map03010 J 50S ribosomal protein l27 COG0211 Cluster_475785 V1233089 YJGK G YhcH YjgK YiaL family protein COG2731 Cluster_237300 V1233090 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_134277 V1233091 RSGA G May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) COG1162 Cluster_159546 V1233092 MNTA map02010 P periplasmic solute binding protein COG0803 Cluster_549058 V1233094 S NA 0ZHU9 Cluster_329102 V1233096 S membrane 11HPM Cluster_702309 V1233097 S VRR-NUC domain protein 122HE Cluster_196973 V1233098 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_463079 V1233100 L NUDIX hydrolase COG0494 Cluster_72487 V1233101 S NA 0YG6V Cluster_95207 V1233102 L Site-specific recombinase COG1961 Cluster_144976 V1233103 L integrase family 0XRS7 Cluster_121392 V1233104 POTE E Amino acid permease COG0531 Cluster_705400 V1233105 S NA 11QY9 Cluster_407080 V1233106 S Domain of unknown function (DUF955) 0ZI1U Cluster_683242 V1233108 PGLC M Bacterial sugar transferase COG2148 Cluster_528879 V1233110 S Protein of unknown function (DUF3408) 11QAR Cluster_307880 V1233111 E Extracellular solute-binding protein, family 5 COG0747 Cluster_326048 V1233112 M domain protein 11EAB Cluster_454983 V1233113 S Membrane 0ZQJM Cluster_127497 V1233114 YOEA V Mate efflux family protein COG0534 Cluster_816953 V1233116 S NA 11EJP Cluster_554840 V1233118 S coat protein 114EC Cluster_197905 V1233119 RIBD map00740,map01100 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) COG1985 Cluster_447026 V1233120 S NA 0ZFM3 Cluster_751565 V1233122 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_373594 V1233126 S NA 0XRBB Cluster_83397 V1233127 V ABC transporter, ATP-binding protein COG1132 Cluster_144977 V1233128 U, W Pfam:Hep_Hag COG5295 Cluster_81753 V1233130 S NA 0YG6V Cluster_233706 V1233131 PHBA map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map02020 I acetyl-coa acetyltransferase COG0183 Cluster_327608 V1233132 S RelA SpoT domain protein COG2357 Cluster_100564 V1233133 GLMU map00520,map01100,map01110 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) COG1207 Cluster_255217 V1233134 PDUX map00860 Q GHMP kinase COG4542 Cluster_734725 V1233135 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_373595 V1233137 S NA 0Y3II Cluster_115568 V1233139 V Restriction modification system DNA (Specificity COG0732 Cluster_350574 V1233140 L site-specific recombinase, phage integrase family 11HGP Cluster_87267 V1233145 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_155298 V1233146 MVAA map00900,map01100,map01110,map04976 I hydroxymethylglutaryL-CoA reductase COG1257 Cluster_152888 V1233148 L integrase family 0XRS7 Cluster_100565 V1233152 S Vitamin K epoxide reductase 11HU3 Cluster_305185 V1233154 METI map02010 P ABC transporter, permease COG2011 Cluster_177797 V1233155 M Sulfatase COG1368 Cluster_744793 V1233156 M transferase family 2 COG0463 Cluster_429017 V1233158 ZUPT P Mediates zinc uptake. May also transport other divalent cations (By similarity) COG0428 Cluster_259060 V1233159 CORA P transporter COG0598 Cluster_475786 V1233161 PS333 L terminase (Small subunit) COG3728 Cluster_92364 V1233162 M Inherit from COG: YD repeat protein COG3209 Cluster_175343 V1233163 GLDE P gliding motility-associated protein GldE COG1253 Cluster_606886 V1233164 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_579582 V1233165 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_140518 V1233169 RV3193C S UPF0182 protein COG1615 Cluster_152889 V1233170 PGM map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_487307 V1233171 RBR C Rubrerythrin COG1592 Cluster_836191 V1233172 NQRE C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG2209 Cluster_94168 V1233173 S NA 0YZ82 Cluster_94696 V1233176 U, W Pfam:YadA COG5295 Cluster_342549 V1233182 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_316865 V1233185 S peptidase 0XPBV Cluster_96814 V1233187 NDVA2 V ABC transporter, ATP-binding protein COG1132 Cluster_403593 V1233188 S Septum formation initiator 0Y1DB Cluster_921515 V1233189 S dedA family COG0586 Cluster_103432 V1233190 RECQ2 map03018 L ATP-dependent DNA helicase RecQ COG0514 Cluster_499813 V1233194 S dNA-binding protein 0Y077 Cluster_425196 V1233196 ACRR K Bacterial regulatory proteins, tetR family COG1309 Cluster_350575 V1233199 S Cell wall-associated COG3863 Cluster_178634 V1233200 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) COG0442 Cluster_162055 V1233201 MELS_0665 L Reverse transcriptase (RNA-dependent DNA polymerase) COG3344 Cluster_104006 V1233202 S NA 17HPJ@proNOG Cluster_104605 V1233203 S Inherit from NOG: antigen PG97 COG4886 Cluster_554841 V1233204 S dNA-binding protein 0Y077 Cluster_105196 V1233206 S NA 0YG6V Cluster_425197 V1233207 S NA 11JHM Cluster_196974 V1233209 UXUA map00040,map01100 G Catalyzes the dehydration of D-mannonate (By similarity) COG1312 Cluster_105197 V1233212 U, W Pfam:YadA COG5295 Cluster_124101 V1233213 FTSK D cell division protein FtsK COG1674 Cluster_207240 V1233214 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_629115 V1233216 L Pfam:Transposase_11 0YB49 Cluster_482706 V1233217 G Aamy_C COG1523 Cluster_169467 V1233218 S NA 11GHR Cluster_121393 V1233220 APEB E M18 family aminopeptidase COG1362 Cluster_107639 V1233221 EA59 S EA59 protein 0XSHM Cluster_259061 V1233222 map00970 J tRNA synthetase valyl leucyl anticodon-binding COG0495 Cluster_342550 V1233228 RPH map00230,map00240,map01100 J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) COG0689 Cluster_467236 V1233229 S NA 123EK Cluster_836192 V1233232 S Periplasmic Protein COG2859 Cluster_324553 V1233234 CARA map00240,map00250,map01100 F carbamoyl-phosphate synthetase glutamine chain COG0505 Cluster_348957 V1233236 S NA 0Y36T Cluster_840075 V1233240 S NA 0YVMU Cluster_114884 V1233241 S NA 0YG6V Cluster_236103 V1233242 M Cpl-7 lysozyme C-terminal domain protein 11GG1 Cluster_115569 V1233243 S NA 101UU Cluster_277714 V1233244 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_405410 V1233245 XPT map00230,map01100,map01110 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) COG0503 Cluster_233707 V1233246 S NA 11QZ9 Cluster_414393 V1233247 RNFG C Electron transport complex, RnfABCDGE type, G subunit COG4659 Cluster_232441 V1233248 NITSA_0073 S transposase 11TFP Cluster_316866 V1233251 S NADP oxidoreductase coenzyme f420-dependent 0ZHKD Cluster_199898 V1233252 GPSA map00564 C NADPH-dependent glycerol-3-phosphate dehydrogenase COG0240 Cluster_310738 V1233253 J HAD-superfamily hydrolase subfamily IA variant 3 COG0637 Cluster_119895 V1233254 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii subunits gamma and tau COG2812 Cluster_507340 V1233256 L integrase family 0ZJHZ Cluster_161217 V1233257 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_276411 V1233258 MENE map00071,map00130,map01100,map01110,map03320,map04146,map04920 H AMP-binding enzyme COG0318 Cluster_398299 V1233262 S NA 0YZMJ Cluster_243891 V1233263 GEOTH_0192 L Transposase (IS4 family 0ZVQ7 Cluster_755018 V1233265 ISCU C SUF system FeS assembly protein COG0822 Cluster_579584 V1233268 POLA_2 L DNA polymerase 0XRUF Cluster_440991 V1233269 S Phage-associated protein 11FS5 Cluster_221985 V1233270 L helicase COG4646 Cluster_296793 V1233271 GLTA map00250,map00910,map01100,map01110,map01120,map01230 E glutamate synthase COG0543 Cluster_292664 V1233274 S NA 101UU Cluster_268414 V1233277 S NA 100CE Cluster_169468 V1233278 NUSA K Transcription elongation factor NusA COG0195 Cluster_429018 V1233279 S NA 0Y88P Cluster_264358 V1233280 S (LipO)protein 0XQ9B Cluster_416167 V1233281 S NA 11X7Q Cluster_164495 V1233282 SCLAV_1560 map02010 P ABC transporter COG1122 Cluster_758545 V1233283 NANA map00300,map00520,map01100,map01110,map01120,map01230 E dihydrodipicolinate COG0329 Cluster_134278 V1233284 FLIC map02020,map02040,map04626,map05132,map05134 N Flagellin COG1344 Cluster_216146 V1233285 S NA 0XY8M Cluster_371973 V1233286 S NA 11ENI Cluster_599685 V1233289 map04210 F DNA RNA NON-specific endonuclease COG1864 Cluster_353743 V1233290 map00860,map01100 H cobaltochelatase, cobn subunit COG1429 Cluster_449050 V1233291 P tonB-dependent Receptor COG4771 Cluster_487308 V1233293 BIOA map00250,map00260,map00330,map00410,map00640,map00650,map00780,map01100 H Catalyzes two activities which are involved in the biotine biosynthesis the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism, and the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA) (By similarity) COG0502 Cluster_412516 V1233294 YGDR E Transporter COG3104 Cluster_382354 V1233296 S NA 0YDPS Cluster_319930 V1233300 S tonB-dependent Receptor 0YAYV Cluster_603262 V1233302 S NA 0YGJW Cluster_653017 V1233305 S NA 0Y5F4 Cluster_141996 V1233307 CAS3 L CRISPR-associated helicase, cas3 COG1203 Cluster_142775 V1233309 SUFB O FeS assembly protein SUFB COG0719 Cluster_206140 V1233310 ALR map00300,map00473,map00550,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_352075 V1233311 RNHA map03030 S Ribonuclease COG3341 Cluster_828568 V1233312 V Inherit from COG: Type II restriction enzyme, methylase COG1002 Cluster_475787 V1233313 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_451018 V1233315 ACPS map00770 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) COG0736 Cluster_610545 V1233318 S rRNA biogenesis protein Rrp5 0XUK3 Cluster_172889 V1233319 SPEB S peptidase C10 11SDT Cluster_637001 V1233320 TRAF2 S conjugative transposon protein TraF 0YJGM Cluster_299472 V1233322 S Inherit from COG: permease COG4200 Cluster_145723 V1233323 S alpha-2-macroglobulin COG2373 Cluster_146518 V1233324 U, W Inherit from COG: domain protein 121KM Cluster_606888 V1233325 BIOF map00260,map00780,map01100 H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) COG0156 Cluster_147293 V1233327 S NA 0YZ82 Cluster_249067 V1233328 EPSG S Capsular polysaccharide biosynthesis protein 0XUBN Cluster_665549 V1233329 M glycosyl transferase family 2 COG0463 Cluster_482707 V1233331 S relaxase mobilization nuclease domain protein 0XNXG Cluster_417972 V1233332 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_436973 V1233337 V type III restriction enzyme 0ZVQ5 Cluster_534482 V1233338 SARE_3740 K Antirepressor COG3645 Cluster_621624 V1233339 S NA 0ZS65 Cluster_330500 V1233340 S Membrane 129H3 Cluster_289990 V1233342 S domain protein 0XNZW Cluster_543070 V1233344 map03070 U NA 0ZZV9 Cluster_338144 V1233345 S NA 11GWB Cluster_417973 V1233346 S NA 0XXN9 Cluster_171153 V1233347 U, W Inherit from COG: domain protein COG5295 Cluster_151219 V1233348 PILT N, U twitching motility protein COG2805 Cluster_152054 V1233352 TRAM S conjugative transposon 0YI63 Cluster_408849 V1233353 S NA 11EP7 Cluster_171154 V1233354 MGTA P magnesium-translocating P-type ATPase COG0474 Cluster_152890 V1233355 M domain protein COG4932 Cluster_405411 V1233356 L resolvase COG1961 Cluster_153661 V1233359 U, W Pfam:YadA COG5295 Cluster_731520 V1233360 S NA 11GXT Cluster_262977 V1233361 GLYQ map00970 J glycyl-tRNA synthetase, alpha subunit COG0752 Cluster_236104 V1233362 YICL E, G Transporter COG0697 Cluster_154460 V1233363 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_840077 V1233364 S conserved domain protein 1280C Cluster_154461 V1233365 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_687667 V1233367 S conjugative transposon protein TraE 11QVH Cluster_586031 V1233368 TRAF S conjugative transposon protein TraF 11IEU Cluster_728213 V1233369 S conjugation system ATPase, TraG family 0XSHU Cluster_350576 V1233371 S NA 0ZWKI Cluster_360440 V1233376 S NA 0Y8K6 Cluster_219632 V1233377 PORU S NA 0XPE4 Cluster_708503 V1233378 RPMA map03010 J 50S ribosomal protein l27 COG0211 Cluster_549060 V1233379 S Thioesterase COG5496 Cluster_596173 V1233381 K Transcriptional regulator COG1167 Cluster_161218 V1233382 GATB map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 Cluster_157827 V1233383 map00052,map00511,map00600,map01100 G Glycoside hydrolase family 2 COG3250 Cluster_275079 V1233384 S coat protein 114EC Cluster_419745 V1233385 S Lipoprotein 0YP1K Cluster_419746 V1233386 P tonB-dependent Receptor 0XNUH Cluster_322973 V1233387 map00051 M Glycosyl transferase, family 2 0ZVME Cluster_460955 V1233391 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_162056 V1233393 S conjugation system ATPase, TraG family 0XSHU Cluster_665550 V1233394 S Protein of unknown function (DUF2807) 11JCU Cluster_259062 V1233395 S NA 0XNWW Cluster_554842 V1233396 BAS0367 map02010 P Binding-protein-dependent transport systems, inner membrane component COG0600 Cluster_412517 V1233397 S conjugative transposon protein TraO 0YB3M Cluster_375305 V1233401 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_419747 V1233402 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_285942 V1233405 S Tetratricopeptide repeat protein 0ZCCT Cluster_423399 V1233406 PSTS2 map02010,map02020,map05152 P Phosphate-binding protein COG0226 Cluster_321408 V1233407 SARE_3740 K Antirepressor COG3645 Cluster_200895 V1233408 U, W surface protein COG5295 Cluster_255218 V1233409 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_848037 V1233413 K Divergent AAA domain COG2865 Cluster_169469 V1233414 RECG map03420,map03440 L transcriptioN-repair coupling factor COG1197 Cluster_170334 V1233415 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_287348 V1233417 S fibronectin type III domain protein 0YCHC Cluster_396581 V1233419 YABB map00340,map00350,map00624,map01120 L Methyltransferase COG4123 Cluster_492161 V1233421 MELS_0665 L Reverse transcriptase (RNA-dependent DNA polymerase) COG3344 Cluster_180334 V1233423 PRC M Peptidase, S41 family COG0793 Cluster_603263 V1233424 PSP1 J endoribonuclease L-psp COG0251 Cluster_231279 V1233426 SARE_3718 S Terminase 11NCI Cluster_216147 V1233427 U, W domain protein COG5295 Cluster_184695 V1233429 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_173716 V1233430 S NA 0ZVZF Cluster_758546 V1233431 OA238_1743 L transposase COG3436 Cluster_221986 V1233432 L Integrase core domain protein COG2801 Cluster_176960 V1233436 S Inherit from NOG: antigen PG97 COG4886 Cluster_292665 V1233438 map02010 P extracellular solute-binding protein COG1840 Cluster_528880 V1233439 S NA 0ZVZF Cluster_224345 V1233440 S NA 0XTEF Cluster_310740 V1233441 L Integrase core domain protein COG2801 Cluster_687668 V1233442 L NA 0YKV1 Cluster_178635 V1233445 YYBT T domain protein COG3887 Cluster_797030 V1233451 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_179505 V1233452 U, W Pfam:YadA COG5295 Cluster_180335 V1233453 S Pfam:YadA 0ZHSU Cluster_261681 V1233454 S NA 100RW Cluster_333560 V1233455 FABG2 map00061,map00780,map01040,map01100 S Oxidoreductase, short chain dehydrogenase reductase family 0XQPQ Cluster_770008 V1233456 S NA 0ZHU9 Cluster_563768 V1233458 NTPK map00190,map00680,map01100 C V-type sodium ATPase, K subunit COG0636 Cluster_777406 V1233459 S Protein of unknown function (DUF2795) 11U61 Cluster_436974 V1233460 YHAI S membrAne COG3152 Cluster_392981 V1233464 TRKA P potassium transporter peripheral membrane COG0569 Cluster_489660 V1233465 P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) COG0168 Cluster_338145 V1233467 TYPA T gtp-binding protein typa COG1217 Cluster_269752 V1233468 M DegT/DnrJ/EryC1/StrS aminotransferase family COG0399 Cluster_255219 V1233470 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_702311 V1233471 PG0695 M major outer membrane protein OmpA 11X18 Cluster_692167 V1233472 S Uncharacterized ACR, COG1399 11J4F Cluster_184696 V1233476 S outer membrane autotransporter barrel domain protein 0XZC6 Cluster_471531 V1233477 S dNA-binding protein 102PX Cluster_485024 V1233478 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III alpha subunit COG0587 Cluster_185569 V1233479 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_187324 V1233480 S The GLUG motif protein family protein 11ZVU Cluster_187325 V1233481 YFJI S NA 0YI8N Cluster_333561 V1233482 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_380584 V1233483 VMRA V Mate efflux family protein COG0534 Cluster_741492 V1233484 S domain protein 0ZZY0 Cluster_187326 V1233485 S Family of unknown function (DUF490) 0Z0C5 Cluster_629116 V1233486 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_515206 V1233487 FBPC map02010 E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COG3842 Cluster_347347 V1233488 YERB S secreted protein 11FHM Cluster_189892 V1233489 L Inherit from COG: DNA Methylase COG0827 Cluster_617960 V1233490 V Hnh endonuclease COG1403 Cluster_189893 V1233491 M outer membrane autotransporter barrel domain protein COG3468 Cluster_189894 V1233492 FRUA map00051,map01100,map02060 G PTS System COG1762 Cluster_276412 V1233493 S NA 0Y056 Cluster_699241 V1233494 P Rhodanese domain protein COG0607 Cluster_190752 V1233495 S NA 0YZ82 Cluster_350577 V1233496 S Amino terminal protease 11T6A Cluster_625405 V1233499 COBD map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01230 E Threonine-phosphate decarboxylase COG0079 Cluster_412518 V1233502 M hydrolase, family 25 COG3757 Cluster_543071 V1233503 S Chromosome segregation ATPase 0XP5N Cluster_755020 V1233504 S NA 0XZ2W Cluster_220818 V1233507 U, W Inherit from COG: domain protein COG5295 Cluster_809191 V1233509 S NA 0XT4D Cluster_692168 V1233510 S Relaxase mobilization nuclease 11PW0 Cluster_414394 V1233511 S NA 0YE9N Cluster_728214 V1233513 S (LipO)protein 11SHJ Cluster_586032 V1233514 S NA 0YIA5 Cluster_193488 V1233515 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_194428 V1233516 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_226635 V1233517 MRCB map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_531699 V1233520 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_414395 V1233522 COBD map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01230 E L-threonine-O-3-phosphate decarboxylase COG0079 Cluster_195307 V1233523 AMS1 map00511 G hydrolase, family 38 COG0383 Cluster_194429 V1233524 S NA 0YZ82 Cluster_196975 V1233526 U, W Pfam:YadA COG5295 Cluster_410708 V1233527 S major tail protein, phi13 family 11ICY Cluster_610546 V1233528 S NA 11QC5 Cluster_198901 V1233529 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_225514 V1233530 Y0750 S Conserved Protein COG1479 Cluster_405412 V1233532 FOLA map00670,map00790,map01100 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) COG0262 Cluster_741494 V1233533 SUFB O FeS assembly protein SUFB COG0719 Cluster_442997 V1233534 S NA 1249W Cluster_199899 V1233535 MURE map00300,map00550,map01100 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_335065 V1233536 U ABC transport system, lipoprotein 0XPU6 Cluster_200896 V1233537 S Inherit from NOG: antigen PG97 COG4886 Cluster_200897 V1233538 S Putative cell wall binding repeat 11PTK Cluster_614202 V1233540 S VRR-NUC domain protein 11X78 Cluster_260366 V1233543 BCGIA V Type II restriction modification enzyme methyltransferase COG0286 Cluster_260367 V1233544 S tonB-dependent Receptor 0XNVP Cluster_326049 V1233545 SDAAA map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase COG1760 Cluster_234902 V1233547 S Recombinase 0Y2JQ Cluster_202937 V1233548 S NA 0YZ82 Cluster_582835 V1233550 S NA 0YIA5 Cluster_507341 V1233555 E peptidase, M24 COG0006 Cluster_202938 V1233556 VIRE2 S Virulence-associated protein e COG5545 Cluster_313757 V1233557 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_203976 V1233558 S NA 101UU Cluster_793072 V1233559 S NA 0Z6G8 Cluster_220819 V1233560 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_497157 V1233562 S NA COG5412 Cluster_586034 V1233563 S NA 0XWWF Cluster_319931 V1233568 S Tetratricopeptide repeat protein 0XUD3 Cluster_208363 V1233570 PERMEASE S permease COG0701 Cluster_570051 V1233572 ARGF map00330,map01100,map01110,map01230 E ornithine carbamoyltransferase COG0078 Cluster_855593 V1233573 ARGF map00330,map01100,map01110,map01230 E ornithine carbamoyltransferase COG0078 Cluster_219633 V1233574 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_246490 V1233575 EDA map00030,map00040,map00330,map00630,map01100,map01120 G aldolase COG0800 Cluster_209407 V1233576 S NA 0YPEU Cluster_327609 V1233579 M Inherit from COG: peptidase' 0XPHJ Cluster_456926 V1233580 ISIB map00910,map01120 C Low-potential electron donor to a number of redox enzymes (By similarity) COG0716 Cluster_348958 V1233581 RPIA map00030,map00710,map01100,map01110,map01120,map01230 G phosphoriboisomerase A COG0120 Cluster_257737 V1233582 MT3047 O DSBA oxidoreductase COG1651 Cluster_210479 V1233583 RV2326C map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_316867 V1233584 MENE map00130,map01100,map01110 H o-succinylbenzoic acid-CoA ligase COG0318 Cluster_210480 V1233586 S fibronectin type III domain protein 0YZ36 Cluster_316868 V1233588 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_731522 V1233589 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III alpha subunit COG0587 Cluster_292666 V1233590 S NA 0YWXK Cluster_212704 V1233591 FLIC map02020,map02040,map04626,map05132,map05134 N Flagellin COG1344 Cluster_299473 V1233593 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_345757 V1233597 map00860,map01100 H Precorrin-2 c20-methyltransferase COG2243 Cluster_256450 V1233598 U, W Domain-Containing protein COG5295 Cluster_302231 V1233599 S GH3 auxin-responsive promoter 0ZVFE Cluster_371974 V1233600 M Inherit from COG: YD repeat protein COG3209 Cluster_385900 V1233602 PROTEASE map05120 O protease COG0826 Cluster_621625 V1233603 CZCD P cation diffusion facilitator family transporter COG0053 Cluster_444984 V1233604 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_482708 V1233605 OPPA map02010 E Extracellular solute-binding protein, family 5 COG4166 Cluster_614203 V1233607 K Phage antirepressor protein KilAC domain COG3645 Cluster_378855 V1233608 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_718267 V1233609 map00052,map00520,map01100,map01110 G, M epimerase COG0451 Cluster_465157 V1233612 S outer membrane lipoprotein carrier protein 11YKN Cluster_456927 V1233613 YCGH Q isochorismatase COG1335 Cluster_335066 V1233614 COBB map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_431004 V1233615 S Colicin V production protein 11EMB Cluster_242539 V1233616 S alpha-2-macroglobulin COG2373 Cluster_540173 V1233620 PLSY map00561,map00564,map01100 S Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) COG0344 Cluster_499814 V1233621 DEOA map00240,map00983,map01100,map05219 F The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) COG0213 Cluster_751566 V1233626 S NA 12065 Cluster_599686 V1233627 S Structural protein 11U4Z Cluster_766278 V1233631 K Inherit from COG: Transcriptional regulator COG3655 Cluster_281721 V1233632 TTCA D Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) COG0037 Cluster_497158 V1233633 S Protein of unknown function (DUF3408) 0ZA41 Cluster_336595 V1233634 S S-layer domain protein 11R54 Cluster_382355 V1233635 S membrane protein involved in aromatic hydrocarbon degradation 0YMT5 Cluster_226636 V1233636 S Inherit from NOG: antigen PG97 0XXCV Cluster_557740 V1233638 V type i restriction modification DNA specificity domain protein COG0732 Cluster_546014 V1233640 PYRE map00240,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_227776 V1233643 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_570052 V1233644 FEOB P Ferrous iron transport protein b COG0370 Cluster_287350 V1233645 M hydrolase, family 25 COG3757 Cluster_494641 V1233647 S NA 0Y615 Cluster_350578 V1233648 S NA 11ENI Cluster_665551 V1233649 ADCC map02010 P ABC transporter COG1121 Cluster_440992 V1233650 PORA map00020,map00720,map01100,map01120 C Oxidoreductase COG1014 Cluster_232443 V1233651 DPNA L helicase COG4646 Cluster_368649 V1233652 K prophage antirepressor COG3617 Cluster_233708 V1233653 S Inherit from NOG: antigen PG97 COG4886 Cluster_352076 V1233654 map00500,map04151,map04910 M synthase COG0438 Cluster_234903 V1233658 M Polysaccharide Biosynthesis Protein COG2244 Cluster_458902 V1233659 YCGH Q isochorismatase COG1335 Cluster_268415 V1233660 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_614204 V1233663 PSSR S acetyltransferase COG0110 Cluster_234904 V1233664 S Endonuclease Exonuclease phosphatase 0XPGG Cluster_236105 V1233665 FECD map02010 P abc transporter COG0609 Cluster_272391 V1233666 TTCA D Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) COG0037 Cluster_816956 V1233670 S outer membrane lipoprotein carrier protein 11YKN Cluster_300846 V1233671 ACD map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I Acyl-coa dehydrogenase COG1960 Cluster_321409 V1233672 map00051 M glycosyltransferase group 2 family protein COG0463 Cluster_237302 V1233673 U, W Domain-Containing protein COG5295 Cluster_238617 V1233675 S s-layer domain-containing protein 11ZJU Cluster_715020 V1233676 GALE map00052,map00520,map00521,map00523,map01055,map01100,map01110 M Male sterility protein COG0451 Cluster_439004 V1233678 ARGS map00970 J arginyL-tRNA synthetase COG0018 Cluster_625406 V1233680 MTGA map00550 M Monofunctional biosynthetic peptidoglycan transglycosylase COG0744 Cluster_241164 V1233681 S S-layer homology domain 11IK1 Cluster_241166 V1233684 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (alpha subunit) COG0587 Cluster_382356 V1233686 S NA 0XS0Q Cluster_828570 V1233687 RPMD map03010 J 50S ribosomal protein L30 COG1841 Cluster_375306 V1233689 S Lysyl endopeptidase 1072U Cluster_348959 V1233690 YJJG map00230,map00240,map00361,map00625,map00760,map01100,map01110,map01120 S Hydrolase COG1011 Cluster_243892 V1233692 NADE map00760,map01100 H Nad synthetase COG0388 Cluster_610547 V1233695 CITD map00020,map01110,map02020 C Covalent carrier of the coenzyme of citrate lyase (By similarity) COG3052 Cluster_246491 V1233697 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_246492 V1233698 V abc transporter permease protein COG0577 Cluster_310741 V1233700 ABPB map00310,map00780,map01100 E Dipeptidase COG4690 Cluster_859595 V1233703 YXKH G polysaccharide deacetylase COG0726 Cluster_347348 V1233704 NAGB map00520,map01100,map01110 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COG0363 Cluster_427122 V1233705 S NA 11H67 Cluster_773691 V1233707 S DivIVA domain protein 11T6K Cluster_398300 V1233712 L Terminase, large subunit COG4626 Cluster_365317 V1233714 Y1701 map05133 U Inherit from COG: filamentous hemagglutinin family outer membrane protein COG3210 Cluster_721591 V1233716 J RNA methyltransferase COG2265 Cluster_251540 V1233717 NUSA K Transcription elongation factor NusA COG0195 Cluster_621626 V1233718 NATA S ABC transporter COG4152 Cluster_463080 V1233722 S Protein of unknown function (DUF3737) 0XTHF Cluster_554844 V1233724 S NA 11W9N Cluster_254012 V1233725 MUTS2 map03430 L muts2 protein COG1193 Cluster_281722 V1233726 S NA 0XNQB Cluster_326050 V1233727 NATB C, P ABC transporter, permease COG1668 Cluster_255220 V1233728 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_259063 V1233729 PQQL O Peptidase, M16 COG0612 Cluster_482709 V1233730 TRXA_2 O Thioredoxin COG0526 Cluster_300847 V1233731 E, G Membrane COG0697 Cluster_353744 V1233732 RECT L recT protein COG3723 Cluster_793073 V1233733 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_875980 V1233734 PGN_0102 K transcriptional repressor, copy family 11TR3 Cluster_257738 V1233735 S fibronectin type III domain protein 0ZQDD Cluster_309294 V1233737 M polysaccharide biosynthesis protein COG2244 Cluster_836195 V1233739 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_344135 V1233740 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_867942 V1233741 TOPB L Dna topoisomerase COG0550 Cluster_321410 V1233743 YEBC K transcriptional regulatory protein COG0217 Cluster_261682 V1233746 S hi0933 family COG2081 Cluster_859596 V1233747 TPIA S doxx family 0XQMY Cluster_871880 V1233748 S NA 0ZHU9 Cluster_272392 V1233750 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_744796 V1233751 S Putative cell wall binding repeat 11WSW Cluster_592697 V1233752 S membrAne 11GVZ Cluster_262978 V1233754 RAGA P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_262979 V1233756 S NA 0YEJA Cluster_653018 V1233757 L DNA methylase n-4 n-6 domain protein COG0863 Cluster_264359 V1233759 TOGA map02010 G ABC transporter related protein COG3839 Cluster_264360 V1233761 GYRA2 L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_265690 V1233764 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_523214 V1233766 CKL_1924 S Predicted membrane protein (DUF2335) COG5346 Cluster_267002 V1233767 HTRB map00540,map01100 M Lipid A Biosynthesis COG1560 Cluster_546015 V1233768 M Glycosyl transferase, family 2 COG1216 Cluster_267003 V1233770 TRAN S Conjugative transposon TraN protein 0XNQ2 Cluster_596174 V1233773 S NA 0YUF4 Cluster_520441 V1233775 L Recombinase COG1961 Cluster_549061 V1233776 S recombinase 11R6K Cluster_291303 V1233788 YDJN S sodium dicarboxylate symporter COG1823 Cluster_273725 V1233789 S NA 0YEDE Cluster_288706 V1233792 GG9_0942 L transposase COG2801 Cluster_275080 V1233795 SPOVK O ATPase, AAA COG0464 Cluster_456928 V1233796 RLUD J pseudouridine synthase COG0564 Cluster_277715 V1233797 S Inherit from NOG: antigen PG97 COG4886 Cluster_277716 V1233799 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_511893 V1023206 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_383745 V1023207 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_458411 V1023209 NORG K Transcriptional regulator COG1167 Cluster_403190 V1023214 HSDM V Type I restriction-modification system, M subunit COG0286 Cluster_401406 V1023216 PDXT map00750 H Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) COG0311 Cluster_318127 V1023217 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_394350 V1023224 S NA 11EIX Cluster_831318 V1023225 S Abortive infection protein AbiGI 11WH3 Cluster_578769 V1023228 S NA 0XTN1 Cluster_643902 V1023230 QUED map00790,map01100 H 6-carboxy-5,6,7,8-tetrahydropterin synthase COG0720 Cluster_268130 V1023231 S Inherit from NOG: antigen PG97 COG4886 Cluster_257473 V1023237 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_496550 V1023238 RPSG map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) COG0049 Cluster_424785 V1023240 MENE map00130,map01100,map01110 H o-succinylbenzoic acid-CoA ligase COG0318 Cluster_839006 V1023241 MSRA O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) COG0225 Cluster_585221 V1023242 RPLS map03010 J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) COG0335 Cluster_336283 V1023247 S NA 11GWB Cluster_426671 V1023248 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_258822 V1023251 M (sortase) family COG3764 Cluster_260130 V1023253 NSPC map00330 E Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) COG0019 Cluster_714244 V1023255 RPSO map03010 J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) COG0184 Cluster_720779 V1023256 S (LipO)protein 0YHGC Cluster_704625 V1023257 COBW S cobalamin synthesis protein COG0523 Cluster_260131 V1023259 S 5 nucleotidase deoxy cytosolic type C 11SZB Cluster_891196 V1023261 S NA 0ZHU9 Cluster_617000 V1023263 BGLB map00460,map00500,map00940,map01100,map01110 G hydrolase family 3 COG1472 Cluster_808228 V1023264 LMRB P Drug resistance transporter EmrB QacA 0XNN3 Cluster_301960 V1023265 COAW map00770,map01100 H Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) COG5146 Cluster_656176 V1023266 MENF map00130,map01053,map01100,map01110 H Isochorismate synthase COG1169 Cluster_514529 V1023267 YDII Q thioesterase Superfamily protein COG2050 Cluster_261439 V1023271 P TonB dependent receptor 0ZJX3 Cluster_509302 V1023272 S septicolysin 11TVT Cluster_491599 V1023273 S NA 0XZ74 Cluster_262728 V1023274 SECD map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) COG0342 Cluster_442554 V1023277 S NA 0YRF6 Cluster_730734 V1023278 FJO13 S Protein of unknown function (DUF3098) 11WHP Cluster_303371 V1023281 SUN J Fmu (Sun) domain-containing protein COG0144 Cluster_273471 V1023282 M Outer membrane efflux protein 0XP27 Cluster_533764 V1023285 S Protein of unknown function (DUF1049) 12CJV Cluster_265431 V1023286 map00511,map00600,map01100,map04142 G hydrolase family 30 COG5520 Cluster_264085 V1023288 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_264086 V1023289 TILS D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) COG0037 Cluster_575678 V1023293 FEOB P Ferrous iron transport protein b COG0370 Cluster_698518 V1023294 L NA 0YKV1 Cluster_363232 V1023296 S Membrane COG3601 Cluster_265432 V1023297 PATB map00270,map00450,map00920,map01100,map01110,map01230 E Aminotransferase class I and II COG1168 Cluster_499203 V1023299 K Transcriptional regulator (AraC family) 11K8N Cluster_430580 V1023300 map00230,map00240,map01100,map03030,map03430,map03440 L exonuclease rnase t and DNA polymerase iii 0Y256 Cluster_639982 V1023302 S NA 0ZHU9 Cluster_356752 V1023304 LOLD map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_511894 V1023306 S Protein of unknown function (DUF2874) 0ZF75 Cluster_647923 V1023307 YQGV S Domain of unknown function DUF77 COG0011 Cluster_266746 V1023312 RSEP map04112 M Membrane-associated zinc metalloprotease COG0750 Cluster_266747 V1023313 L DNA Methylase COG2189 Cluster_572449 V1023315 YJGN S Membrane COG4269 Cluster_656177 V1023316 YJGM K acetyltransferase 1780I@proNOG Cluster_351764 V1023320 S NA 0XZUM Cluster_870919 V1023322 PHOR map02020 T Histidine kinase 0XNMH Cluster_664529 V1023323 RHLE map03018 L Helicase COG0513 Cluster_456484 V1023324 SUPH S Hydrolase COG0561 Cluster_691185 V1023328 RHAT7 E, G Transporter COG0697 Cluster_426672 V1023329 TNPS L Integrase 16QYQ@proNOG Cluster_560068 V1023331 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_269502 V1023333 AAP map05150 M surface protein 0XSC2 Cluster_269503 V1023334 DNAG map03030 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 Cluster_470999 V1023335 map00350,map00362,map00627,map00642,map00903,map01120 K Acetyltransferase GNAT Family COG0454 Cluster_511895 V1023336 YQEY S gatB Yqey COG1610 Cluster_353448 V1023340 L D12 class N6 adenine-specific DNA methyltransferase 110K5 Cluster_368323 V1023341 YFKO C Nitroreductase COG0778 Cluster_847165 V1023346 S NA 0ZEAT Cluster_270821 V1023347 M Inherit from NOG: Polymorphic outer membrane protein 11KKP Cluster_525416 V1023350 YIAA S YiaAB two helix domain-containing protein COG4682 Cluster_309023 V1023351 S Relaxase mobilization nuclease 11PW0 Cluster_343820 V1023353 V Protein export membrane protein COG0841 Cluster_378475 V1023358 UPP map00240,map01100 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) COG0035 Cluster_319664 V1023359 MT0235 map00051 M glycosyl transferase group 1 COG0438 Cluster_306292 V1023361 RPSB map03010 J 30S ribosomal protein S2 COG0052 Cluster_617001 V1023364 S NA 12490 Cluster_272115 V1023368 S tonB-dependent Receptor 0Y4TD Cluster_380178 V1023371 MT3758 U Type ii secretion system COG4965 Cluster_780107 V1023373 K Transcriptional regulator 121UZ Cluster_796117 V1023375 MTNN map00270,map01100 F Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) COG0775 Cluster_452519 V1023377 SP_0341 S UPF0371 protein COG4868 Cluster_557018 V1023378 K Transcriptional regulator COG0789 Cluster_272116 V1023379 MALL map00052,map00500,map01100 G trehalose-6-phosphate hydrolase (EC 3.2.1.93) COG0366 Cluster_273472 V1023381 SOV S Gliding motility-related protein 0XPT8 Cluster_714245 V1023382 LDRD S NA 17UYD@proNOG Cluster_273473 V1023383 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_539534 V1023385 S NA 12CKW Cluster_299219 V1023388 L Phage Integrase Family COG0582 Cluster_274822 V1023389 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit epsilon COG0847 Cluster_342221 V1023391 TILS D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) COG0037 Cluster_337801 V1023392 PSTS map02010,map02020,map05152 P Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) COG0226 Cluster_698521 V1023394 ISPD map00900,map01100,map01110 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COG1211 Cluster_274823 V1023395 SPMB S nucleoside recognition domain protein COG2715 Cluster_273474 V1023396 S Inherit from NOG: domain protein 18D01@proNOG Cluster_274824 V1023400 BL03073 S Collagen triple helix repeat 101DM Cluster_398301 V1233801 S Chap domain containing protein 0XP7Y Cluster_277717 V1233802 S Virulence-associated protein e COG5545 Cluster_482710 V1233805 S NA 0XRRN Cluster_279075 V1233807 V Mate efflux family protein COG0534 Cluster_338146 V1233808 UDP map00240,map00983,map01100 F Phosphorylase COG2820 Cluster_285943 V1233809 S domain protein 0YF83 Cluster_744797 V1233812 S NA 0XVHI Cluster_793074 V1233813 RUVX L Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) COG0816 Cluster_884183 V1233814 S YitT family COG1284 Cluster_425198 V1233815 SOV S Gliding motility-related protein 0XPT8 Cluster_287351 V1233816 MYCA S Myosin-Cross-Reactive Antigen COG4716 Cluster_281723 V1233818 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_283123 V1233820 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (Alpha subunit) COG0587 Cluster_283124 V1233821 TRAG map03070 U TraG TraD family protein COG3505 Cluster_678693 V1233822 S NGG1p interacting factor 3 protein, NIF3 COG3323 Cluster_284492 V1233823 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_614205 V1233824 C domain protein 0ZQ9H Cluster_718269 V1233825 PPDK map00620,map00710,map01100,map01120 G Pyruvate phosphate dikinase COG0574 Cluster_563769 V1233826 S Thioesterase 11QVX Cluster_318444 V1233827 E Peptidase, S9A B C family, catalytic domain protein COG1506 Cluster_284493 V1233828 S NA 0XNWW Cluster_371975 V1233829 S ParB-like nuclease domain 0ZJMC Cluster_497159 V1233830 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_285944 V1233831 S domain protein 0XPXI Cluster_452965 V1233837 DGT map00230 F deoxyguanosinetriphosphate triphosphohydrolase-like protein COG0232 Cluster_851817 V1233840 M NA 0YN3I Cluster_414396 V1233842 POLA_2 L DNA polymerase 0XRUF Cluster_289991 V1233844 PGCA map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_289992 V1233845 SARE_3718 S Terminase 11NCI Cluster_288708 V1233846 U, W Pfam:YadA COG5295 Cluster_416168 V1233847 S NA 11W9N Cluster_289993 V1233848 S NA 0YJTQ Cluster_289994 V1233849 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_316869 V1233850 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_512509 V1233855 AHPC O Peroxiredoxin COG0450 Cluster_291304 V1233857 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_494642 V1233858 RPIA map00030,map00710,map01100,map01110,map01120,map01230 G phosphoriboisomerase A COG0120 Cluster_292667 V1233860 RBSK map00030 G ribokinase COG0524 Cluster_375307 V1233861 S (LipO)protein 11H2K Cluster_614206 V1233863 S Inherit from NOG: Pfam:DUF88 0XSP1 Cluster_724934 V1233866 RSMG M Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) COG0357 Cluster_805157 V1233868 SCLAV_4550 L UPF0102 protein COG0792 Cluster_295453 V1233869 S NA 11EKV Cluster_295455 V1233871 S Pfam:YadA 0ZHSU Cluster_820769 V1233872 S NA 0ZHU9 Cluster_296794 V1233873 RLUB J pseudouridine synthase COG1187 Cluster_296795 V1233875 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_363578 V1233877 PYRP F permease COG2233 Cluster_458903 V1233879 TAL map00030,map01100,map01110,map01120,map01230 G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) COG0176 Cluster_300848 V1233885 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_300849 V1233886 YKOD map02010 P ABC transporter COG1122 Cluster_408850 V1233887 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_299474 V1233888 PURB map00230,map00250,map01100,map01110 F Adenylosuccinate lyase COG0015 Cluster_451020 V1233889 S NA 11PP9 Cluster_302232 V1233894 CLPC O chaperone COG0542 Cluster_442998 V1233896 S NA 11QED Cluster_467237 V1233899 P TonB-dependent receptor Plug 0XNPQ Cluster_303684 V1233901 V Inherit from COG: Type II restriction enzyme, methylase COG1002 Cluster_403594 V1233902 S NA 124K8 Cluster_305186 V1233903 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_305187 V1233904 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_305188 V1233905 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_306570 V1233910 OMPA2 M OmpA MotB domain-containing protein COG2885 Cluster_391166 V1233911 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_592698 V1233913 RPSS map03010 J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) COG0185 Cluster_305189 V1233914 S Pfam:YadA 0ZHSU Cluster_793076 V1233915 VIRE2 S Virulence-associated protein e COG5545 Cluster_414397 V1233916 HBP35 S NA 0YVX1 Cluster_306571 V1233917 SUN map00340,map00350,map00624,map01120 J NOL1 NOP2 sun family protein COG0144 Cluster_306572 V1233918 S NA 0ZVZF Cluster_306574 V1233923 VEX2 V abc transporter atp-binding protein COG1136 Cluster_674247 V1233926 G Major Facilitator COG0477 Cluster_307881 V1233927 M outer membrane autotransporter barrel domain protein COG3468 Cluster_313758 V1233928 TRAN S Conjugative transposon TraN protein 0XNQ2 Cluster_373596 V1233935 APEB E M18 family aminopeptidase COG1362 Cluster_904942 V1233939 GLTA map00250,map00910,map01100,map01110,map01120,map01230 E glutamate synthase COG0493 Cluster_377078 V1233941 K Transcriptional regulator, TetR family 128VI Cluster_312262 V1233943 S NA 0XQ20 Cluster_335067 V1233944 SUHB map00521,map00562,map01100,map01110,map04070 G inositol monophosphatase COG0483 Cluster_312263 V1233948 P TonB-dependent receptor Plug 0XNPQ Cluster_371976 V1233954 S NA 16XT2@proNOG Cluster_396582 V1233955 P tonB-dependent Receptor COG1629 Cluster_315338 V1233958 MGTA P magnesium-translocating P-type ATPase COG0474 Cluster_380587 V1233959 S NA 0XUFW Cluster_316870 V1233960 S NA 11VF8 Cluster_375308 V1233962 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_318445 V1233967 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_396583 V1233968 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG2812 Cluster_318446 V1233971 MOD L DNA methylase COG2189 Cluster_350579 V1233972 DEAD map03018 L ATP-dependent RNA helicase COG0513 Cluster_863939 V1233975 S NA 0ZHU9 Cluster_319933 V1233976 map00500,map01100 N Alpha-L-fucosidase 0XPGV Cluster_816957 V1233978 map03440 L UvrD REP helicase COG1074 Cluster_321411 V1233980 U, W Pfam:HIM COG5295 Cluster_335068 V1233981 map02010 E extracellular solute-binding protein family 1 COG0687 Cluster_871884 V1233982 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_554845 V1233983 S Uncharacterised protein family (UPF0104) COG0392 Cluster_321412 V1233985 GLGB map00500,map01100,map01110 G pullulanase, type i COG1523 Cluster_350580 V1233986 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_427123 V1233987 N Bacterial Ig-like domain (group 2) 11ERB Cluster_863940 V1233988 O AhpC TSA family COG0526 Cluster_338147 V1233990 MEXF V AcrB AcrD family multidrug resistance protein COG0841 Cluster_324554 V1233991 S spore coat protein CotH 0YUJE Cluster_322974 V1233992 ALST map02020 E Sodium alanine symporter COG1115 Cluster_421541 V1233993 ELI_1297 O phage portal protein HK97 family COG4695 Cluster_362013 V1233995 PHOH T Phoh family COG1702 Cluster_324555 V1233996 S Phage minor structural protein, N-terminal domain protein 11ZGW Cluster_485025 V1233998 RRMJ J Hemolysin A COG1189 Cluster_699242 V1234000 SUFE S Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) COG2166 Cluster_324557 V1234001 RECG map03420,map03440 L transcriptioN-repair coupling factor COG1197 Cluster_434916 V1234002 RNHA map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0328 Cluster_391167 V1234003 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_326053 V1234006 AROK map00400,map01100,map01110,map01230 E Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) COG0703 Cluster_327610 V1234009 ISPG map00900,map01100,map01110 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) COG0821 Cluster_385901 V1234010 P tonB-dependent siderophore receptor COG1629 Cluster_427124 V1234011 V type I restriction modification DNA specificity domain protein COG0732 Cluster_423400 V1234012 L DNA alkylation repair enzyme 0YG23 Cluster_606892 V1234013 S NA 0Z27T Cluster_330501 V1234015 S NA 0YB9V Cluster_330502 V1234017 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_494643 V1234020 map02010 P ABC 3 transport family protein COG1108 Cluster_785282 V1234023 TRA L transposase COG2826 Cluster_444985 V1234024 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_332064 V1234025 L Integrase 0YTFQ Cluster_336596 V1234027 S NA 10YAQ Cluster_335069 V1234031 NANA map00300,map00520,map01100,map01110,map01120,map01230 E, M Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate (By similarity) COG0329 Cluster_512510 V1234035 S NA 11EJC Cluster_440993 V1234038 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_451021 V1234040 INSI L transposase COG2826 Cluster_517883 V1234041 S Domain of unknown function DUF87 0ZJHN Cluster_492162 V1234042 map00860,map01100 H Heme-binding protein FetB COG4822 Cluster_507342 V1234043 RDGB map00230,map00240,map01100 F Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) COG0127 Cluster_467238 V1234045 ATPE map00190,map00680,map01100 C ATP synthase, subunit E 11I9P Cluster_338148 V1234046 MNME S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 Cluster_589338 V1234049 M Nucleoside-diphosphate-sugar pyrophosphorylase 0ZRVF Cluster_546017 V1234055 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_451022 V1234058 DEF J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) COG0242 Cluster_344136 V1234059 U, W YadA domain protein COG5295 Cluster_341029 V1234061 S NA 0YZ82 Cluster_341030 V1234062 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_342551 V1234063 S NA 11K71 Cluster_793077 V1234065 S NA 0Y16N Cluster_392982 V1234071 HTPG map04141,map04151,map04612,map04621,map04626,map04914,map04915,map05200,map05215 O Molecular chaperone. Has ATPase activity (By similarity) COG0326 Cluster_447027 V1234072 V type I restriction modification COG0732 Cluster_342554 V1234073 M Membrane COG4775 Cluster_408852 V1234074 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_570054 V1234075 S Lipoprotein 0YP1K Cluster_344137 V1234076 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_610549 V1234078 S NA 0ZHU9 Cluster_350581 V1234080 MURI map00471,map01100 M Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) COG0796 Cluster_345758 V1234082 DRAG O ADP-ribosylation crystallin J1 COG1397 Cluster_793078 V1234086 V Restriction modification system DNA specificity subunit 1708W@proNOG Cluster_512511 V1234087 V Type I restriction modification DNA specificity domain COG0732 Cluster_345759 V1234088 SDHA map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020,map05134 C succinate dehydrogenase, flavoprotein subunit COG1053 Cluster_347349 V1234089 V DNA specificity domain COG0732 Cluster_355412 V1234090 map02010 V ABC-2 type transporter COG0842 Cluster_431006 V1234091 RPLE map03010 J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COG0094 Cluster_640998 V1234094 S NA 11EQ4 Cluster_540174 V1234095 S NA 0YYZU Cluster_348960 V1234096 P TonB dependent receptor 0YB7D Cluster_348961 V1234097 MSBA map02010 V ABC transporter, ATP-binding protein COG1132 Cluster_440994 V1234102 S Protein of unknown function (DUF3164) 11TRN Cluster_705403 V1234105 S NA 11EKD Cluster_487309 V1234106 map00770,map01100 H Pantothenate kinase 109YT Cluster_401817 V1234107 RLUB J Pseudouridine synthase COG1187 Cluster_431007 V1234110 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_352077 V1234111 S basic membrane COG1744 Cluster_350582 V1234112 FNI map00900,map01100,map01110 C Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) COG1304 Cluster_352078 V1234113 GLGD map00500,map00520,map01100,map01110 M glucose-1-phosphate adenylyltransferase, glgd subunit COG0448 Cluster_454985 V1234117 PACL P P-type ATPase COG0474 Cluster_449051 V1234118 ABCD map02010 P ABC transporter, permease COG2011 Cluster_353745 V1234119 S pspC domain protein 0ZVHH Cluster_531700 V1234121 S NA 11VF8 Cluster_355413 V1234124 NOX map00190 P pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_543072 V1234126 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Involved in acetate metabolism (By similarity) COG0280 Cluster_382357 V1234127 L DNA uptake protein and related DNA-binding COG1555 Cluster_661366 V1234128 DINB L Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) COG0389 Cluster_596175 V1234129 FOLB map00790,map01100 H dihydroneopterin aldolase COG1539 Cluster_355415 V1234135 S Rib/alpha-like repeat 0YK85 Cluster_357101 V1234137 S membrane protein involved in aromatic hydrocarbon degradation 0YMT5 Cluster_357102 V1234138 S Putative cell wall binding repeat 11WSW Cluster_357103 V1234139 S (LipO)protein 11H2K Cluster_629117 V1234141 L Transposase (IS4 family 0ZJC4 Cluster_357104 V1234142 DACET_1463 S DNA-binding protein COG3943 Cluster_358770 V1234145 FTSI map00550 M penicillin-binding protein COG0768 Cluster_358771 V1234147 S (LipO)protein 11SHJ Cluster_358772 V1234149 S ATPase (AAA COG1373 Cluster_492163 V1234150 MVAD map00900,map01100,map01110 I diphosphomevalonate decarboxylase COG3407 Cluster_360441 V1234151 F Endonuclease Exonuclease phosphatase COG2374 Cluster_394801 V1234153 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_789283 V1234155 S Protein of unknown function (DUF2582) 0XWWH Cluster_360442 V1234158 S abc transporter atp-binding protein COG1101 Cluster_499816 V1234159 S Domain of unknown function (DUF1896) 0YBI2 Cluster_509933 V1234160 U, W Inherit from COG: domain protein COG5295 Cluster_362014 V1234162 S copper amine 121X1 Cluster_840085 V1234165 S NA 11W9N Cluster_362015 V1234166 P integral membrane protein COG0861 Cluster_363579 V1234168 TRPB map00260,map00400,map01100,map01110,map01230 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) COG0133 Cluster_363580 V1234169 U, W Inherit from COG: domain protein COG5295 Cluster_363581 V1234170 M NA 0YE4B Cluster_800961 V1234171 WBPD map00520 S Transferase hexapeptide repeat containing protein COG0110 Cluster_512512 V1234173 S Chap domain containing protein 0XP7Y Cluster_365318 V1234174 GAPB map00010,map00710,map01100,map01110,map01120,map01230,map04066,map05010 G Glyceraldehyde-3-phosphate dehydrogenase, type I COG0057 Cluster_365319 V1234177 L Domain protein COG0507 Cluster_499817 V1234178 S NA 0YG1I Cluster_523215 V1234179 LPDA map00010,map00020,map00260,map00280,map00620,map01100,map01110,map01120 C Dihydrolipoyl dehydrogenase COG1249 Cluster_824762 V1234180 PACL P P-type ATPase COG0474 Cluster_365320 V1234181 PEPQ map00310,map00780,map01100 E peptidase M24 COG0006 Cluster_449052 V1234182 S NA 11UZG Cluster_365321 V1234183 S Pfam:DUF477 COG1512 Cluster_365322 V1234184 RAGA P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_367037 V1234186 S ragb susd domaiN-containing protein 0XP53 Cluster_925478 V1234188 S Membrane COG2035 Cluster_520444 V1234189 S NA COG4430 Cluster_368650 V1234192 MT2802 S atpase involved in dna repair 0XNTH Cluster_549062 V1234194 TRBF map03070 U Conjugal transfer protein COG3701 Cluster_751568 V1234195 TILS D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) COG0037 Cluster_566968 V1234197 V DNA specificity domain COG0732 Cluster_543073 V1234198 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_370355 V1234199 L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) COG0582 Cluster_434917 V1234200 SP_0161 K, T lytTr DNA-binding domain protein COG3279 Cluster_469368 V1234201 S Toprim domain protein 0ZC02 Cluster_371977 V1234202 S Inherit from NOG: antigen PG97 COG4886 Cluster_489662 V1234204 V Inherit from COG: Type II restriction enzyme, methylase COG1002 Cluster_844124 V1234205 MVAS map00072,map00280,map00650,map00900,map01100,map01110 I Hydroxymethylglutaryl-CoA synthase COG3425 Cluster_371978 V1234206 PRIA map03440 L Primosomal protein n' COG1198 Cluster_419748 V1234208 YEGQ map05120 O Peptidase U32 COG0826 Cluster_373597 V1234209 ADCA map02010 P periplasmic solute binding protein COG0803 Cluster_394802 V1234210 FNI map00900,map01100,map01110 C Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) COG1577 Cluster_373598 V1234213 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_387737 V1234214 PEPO O Endothelin-converting enzyme 1 COG3590 Cluster_373599 V1234215 GCVPA map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG0403 Cluster_375310 V1234220 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_375311 V1234222 U, W Inherit from COG: domain protein 121KM Cluster_661369 V1234224 S NA 0ZHU9 Cluster_888103 V1234226 S single-strand binding family protein 0XS6K Cluster_546018 V1234227 S Inherit from NOG: Phage-associated protein 0XWN8 Cluster_582836 V1234229 YAAT S psp1 domain protein COG1774 Cluster_537377 V1234232 L Inherit from COG: transposase COG1943 Cluster_378856 V1234233 MEND map00130,map01100,map01110 H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) COG1165 Cluster_378857 V1234239 PGMA S OmpA family 11HEJ Cluster_378858 V1234240 S NA 0YUF4 Cluster_378859 V1234241 S domain protein 0XPXI Cluster_378860 V1234242 S NA 0YUF4 Cluster_429020 V1234243 HFLC O SPFH domain, Band 7 family protein COG0330 Cluster_378861 V1234244 S Pfam:YadA 0ZHSU Cluster_378862 V1234245 NUCA map04210 F DNA RNA NON-specific endonuclease COG1864 Cluster_473634 V1234247 AMID map02010 P ABC transporter COG1173 Cluster_431008 V1234250 L Domain protein COG0507 Cluster_380588 V1234251 S NA 11YT1 Cluster_447028 V1234255 HISC map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01230 E Imidazole acetol-phosphate transaminase COG0079 Cluster_382359 V1234256 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_384128 V1234260 S Lysyl endopeptidase 1072U Cluster_382361 V1234262 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_504756 V1234264 MFA2 S Pfam:DUF1812 0YJ58 Cluster_382362 V1234265 S Family of unknown function (DUF490) 0XPFA Cluster_392983 V1234266 U, W Inherit from COG: domain protein 121KM Cluster_820774 V1234268 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_515209 V1234269 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_551948 V1234270 S tpr domain protein 12228 Cluster_487310 V1234272 CDD map00240,map00983,map01100,map05219 F cytidine deaminase COG0295 Cluster_551949 V1234273 RECR map03440 L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) COG0353 Cluster_423401 V1234274 U TraG family COG3505 Cluster_625408 V1234276 CYCMA_0607 S transposase 11H93 Cluster_816959 V1234279 S HTH domain protein 11Z0Z Cluster_385903 V1234281 YEIH S Membrane COG2855 Cluster_731528 V1234282 NADE map00760,map01100 H Nad synthetase COG0388 Cluster_751569 V1234285 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_487311 V1234286 HPPA map00190 C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for COG3808 Cluster_387738 V1234287 CKL_1893 S Phage replisome organizer 11V35 Cluster_824764 V1234289 L NA 0Z8MW Cluster_702312 V1234293 S Nudix family 11RXE Cluster_557743 V1234294 MTNN map00270,map01100 F Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) COG0775 Cluster_460957 V1234295 POTA map02010 E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COG3842 Cluster_389434 V1234296 GLNS map00970,map01100 J glutaminyL-tRNA synthetase COG0008 Cluster_391168 V1234300 HBP35 S NA 0YVX1 Cluster_389435 V1234302 S NA 11VF8 Cluster_469369 V1234307 PDXT map00750 H Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) COG0311 Cluster_777412 V1234308 GROS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) COG0234 Cluster_392984 V1234309 L integrase family 0ZJHZ Cluster_440995 V1234310 P tonB-dependent Receptor 0XNUH Cluster_563770 V1234311 T FHA domain protein 11FQP Cluster_394803 V1234312 RV1313C L transposase, IS204 IS1001 IS1096 IS1165 family protein COG3464 Cluster_394806 V1234316 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_394807 V1234317 S (LipO)protein 0XSFR Cluster_454986 V1234318 V ABC transporter COG1132 Cluster_718271 V1234319 S Protein of unknown function (DUF1232) 1221F Cluster_396584 V1234320 HSDS V restriction modification system DNA specificity domain COG0732 Cluster_537378 V1234323 L Recombinase COG1961 Cluster_398303 V1234326 GLGB map00500,map01100,map01110 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) COG0296 Cluster_407081 V1234334 TIG O Trigger factor COG0544 Cluster_467241 V1234336 S Phage prohead protease, HK97 family COG3740 Cluster_637002 V1234339 S Structural protein 11U4Z Cluster_400040 V1234342 SOV S Gliding motility-related protein 0XPT8 Cluster_401818 V1234344 S NA 0YBZF Cluster_401819 V1234347 U, W Domain-Containing protein COG5295 Cluster_401820 V1234348 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_458904 V1234349 BL01967 P trap transporter solute receptor taxi family COG2358 Cluster_401821 V1234350 TOPB L Dna topoisomerase COG0550 Cluster_515210 V1234353 S The GLUG motif protein family protein 11ZVU Cluster_401822 V1234354 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_403595 V1234360 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_416169 V1234361 S NA 101UU Cluster_405413 V1234362 S NA 0YNH7 Cluster_465158 V1234365 NRDG O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) COG0602 Cluster_405414 V1234368 BGAA map00052,map00511,map00600,map01100 G glycoside hydrolase family 2 COG3525 Cluster_738091 V1234372 CLPB O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_499818 V1234379 ISPE map00900,map01100,map01110 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COG1947 Cluster_408853 V1234380 S NA 11EKV Cluster_408854 V1234381 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_419750 V1234382 BCGIA V Type II restriction modification enzyme methyltransferase COG0286 Cluster_563772 V1234383 PSTS map02010,map02020,map05152 P Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) COG0226 Cluster_440996 V1234385 S RecT family 0YHMQ Cluster_408855 V1234386 L TatD family COG0084 Cluster_410710 V1234392 MIAB J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) COG0621 Cluster_454987 V1234394 PCP O Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) COG2039 Cluster_443000 V1234398 S NA 10RN8 Cluster_489663 V1234401 MAZG map00230,map00240,map01100 F mazG family COG1694 Cluster_414398 V1234404 PQQL O Peptidase, M16 COG0612 Cluster_669854 V1234411 PORQ S NA 11GCX Cluster_699244 V1234415 map00511,map04142 G beta-mannosidase EC 3.2.1.25 COG3250 Cluster_888104 V1234418 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_487312 V1234419 S protein, conserved in bacteria COG4506 Cluster_711637 V1234420 TOPB L Dna topoisomerase COG0550 Cluster_705404 V1234421 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_546019 V1234427 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_416170 V1234428 S NA 0YZ82 Cluster_416171 V1234430 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_417974 V1234432 HSDR V type I restriction enzyme EcoKI subunit R COG4096 Cluster_419751 V1234436 TGT J Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COG0343 Cluster_805161 V1234439 S NA 17D58@proNOG Cluster_417976 V1234440 POLA_2 L DNA polymerase 0XRUF Cluster_492164 V1234441 S RumE protein 0Z8VP Cluster_419752 V1234442 L Recombinase COG1961 Cluster_419753 V1234446 GCVT map00260,map00670,map00910,map01100 E The glycine cleavage system catalyzes the degradation of glycine (By similarity) COG0404 Cluster_517884 V1234447 YCHF J gtp-binding protein COG0012 Cluster_586036 V1234448 S kila-n, DNA-binding domain 0XPNQ Cluster_421544 V1234452 SPEB S peptidase C10 11SDT Cluster_421545 V1234454 HSDM V Type I restriction-modification system, M subunit COG0286 Cluster_423402 V1234458 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_423403 V1234459 V Type III restriction enzyme, res subunit 0ZVEA Cluster_540176 V1234464 S Inherit from NOG: Leucine rich repeat protein 0Y0WF Cluster_644872 V1234465 S Immunoreactive 84 kDa antigen 0Y0NA Cluster_423406 V1234466 S NA 0YF1V Cluster_425201 V1234467 M Inherit from NOG: domain protein 0XQTW Cluster_425202 V1234469 SUN_0728 L transposase (IS4 family) protein 12CNV Cluster_427125 V1234471 U, W Pfam:YadA COG5295 Cluster_425203 V1234472 S Inherit from COG: leucine Rich Repeat COG4886 Cluster_429021 V1234478 S NA 11HA5 Cluster_444986 V1234479 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_648943 V1234481 FUSA2 T elongation factor g COG0480 Cluster_758551 V1234482 FUSA2 T elongation factor g COG0480 Cluster_427126 V1234484 S Melibiase 1003M Cluster_661370 V1234489 NNRD G Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) COG0063 Cluster_715025 V1234492 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_433001 V1234497 M Glycosyl transferase (Group 1 COG0438 Cluster_494644 V1234498 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0847 Cluster_851824 V1234500 NADD map00230,map00760,map01100,map05340 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) COG1057 Cluster_434919 V1234502 L Terminase, large subunit COG4626 Cluster_434920 V1234504 S NA 126TR Cluster_579588 V1234507 S NA 0ZP8G Cluster_504757 V1234509 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01230 G phosphohexose isomerase COG0166 Cluster_434922 V1234512 LOLC map02010 M lipoprotein releasing system transmembrane protein COG4591 Cluster_482711 V1234515 OCAR_6158 L Terminase, large subunit COG4626 Cluster_436976 V1234516 RECG map03440 L ATP-dependent DNA helicase recg COG1200 Cluster_434923 V1234517 RNFG C Electron transport complex COG4659 Cluster_692170 V1234518 SUN_0728 L transposase (IS4 family) protein 12CNV Cluster_436977 V1234519 HIPO map00360 E amidohydrolase COG1473 Cluster_599687 V1234521 SELA map00450,map00970 E Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) COG1921 Cluster_436978 V1234522 S NA 11VF8 Cluster_436979 V1234526 UGD map00040,map00053,map00500,map00520,map01100,map01110 M UDP-glucose 6-dehydrogenase COG1004 Cluster_734728 V1234527 ATPC map00190,map00195,map01100 C ATP synthase, Delta Epsilon 11YZG Cluster_781153 V1234530 L NA 0YZ4U Cluster_439006 V1234533 CAS2 L CRISPR-associated protein cas2 11VHR Cluster_644873 V1234535 S NA 0ZHU9 Cluster_718273 V1234538 M Auxiliary transport protein, membrane fusion protein COG0845 Cluster_439007 V1234539 BMPA S basic membrane COG1744 Cluster_439008 V1234540 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_439009 V1234541 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_439010 V1234542 S Membrane 0XRRH Cluster_447029 V1234543 BCGIA V Type II restriction modification enzyme methyltransferase COG0286 Cluster_463081 V1234544 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_439011 V1234545 RECR map03440 L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) COG0353 Cluster_440997 V1234546 S Terminase, large subunit COG1783 Cluster_439012 V1234547 PLPD S Patatin-like phospholipase COG1752 Cluster_603264 V1234549 PGN_0049 S Antirestriction protein COG4734 Cluster_475788 V1234553 S NA 0XT33 Cluster_502355 V1234555 Y2322 S repeat protein 127QI Cluster_859602 V1234556 S virulence-like protein 0ZW8F Cluster_758552 V1234557 S NA 0ZXT9 Cluster_840088 V1234558 S NA 0XXBY Cluster_440998 V1234559 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_487313 V1234561 PURN map00230,map00670,map01100,map01110 F phosphoribosylglycinamide formyltransferase COG0299 Cluster_629119 V1234563 S NA 122DJ Cluster_465159 V1234565 S DNA alkylation repair enzyme 11EKC Cluster_443001 V1234566 PGMA S OmpA family 11HEJ Cluster_443002 V1234569 S NA 0YB9V Cluster_499819 V1234570 S NA 0ZGXW Cluster_758553 V1234571 KDGR K Transcriptional regulator COG1609 Cluster_443004 V1234573 S Phage minor structural protein, N-terminal domain protein 11ZGW Cluster_452967 V1234575 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_614210 V1234577 S NA 0XRRN Cluster_444987 V1234578 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120 G phosphohexose isomerase COG0166 Cluster_444988 V1234579 S NA 121T2 Cluster_444989 V1234580 SPOT map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_444990 V1234581 RPSP map03010 J 30s ribosomal protein S16 COG0228 Cluster_549063 V1234582 PEPE E Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) COG3340 Cluster_444991 V1234585 SECD map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) COG0342 Cluster_444992 V1234586 S NA 0Y8RQ Cluster_777413 V1234587 META map00270,map00920,map01100,map01110,map01230 E Homoserine O-transsuccinylase COG1897 Cluster_447030 V1234588 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_444993 V1234590 S Inherit from COG: leucine Rich Repeat COG4886 Cluster_702314 V1234592 RSEP map04112 M Membrane-associated zinc metalloprotease COG0750 Cluster_447031 V1234593 S alpha-2-macroglobulin COG2373 Cluster_487314 V1234594 CLPB O ATP-dependent chaperone protein ClpB COG0542 Cluster_447032 V1234595 S (twin-arginine translocation) pathway signal 11PG4 Cluster_447033 V1234596 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG1754 Cluster_512513 V1234601 S phage tail component domain protein 11VYN Cluster_447035 V1234605 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_487315 V1234606 ADK map00230,map00240,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_447036 V1234607 SP_1358 map02010 V ABC transporter, ATP-binding protein COG1132 Cluster_610550 V1234608 S Tellurite resistance protein TerB 11EIH Cluster_449054 V1234609 HBP35 S NA 0YVX1 Cluster_648944 V1234613 S spore coat protein CotH 0YUJE Cluster_449055 V1234614 S Inherit from NOG: antigen PG97 COG4886 Cluster_451023 V1234615 S Protein of unknown function (DUF2958) 11V8J Cluster_451024 V1234616 S NA 0ZJP4 Cluster_517887 V1234619 map00362,map01100,map01120 C Hydrolase COG0596 Cluster_451026 V1234621 MURD map00471,map00550,map01100 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COG0771 Cluster_499820 V1234622 S Structural protein 11PKS Cluster_724936 V1234623 PURE map00230,map01100,map01110 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) COG0041 Cluster_452968 V1234624 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_452969 V1234625 FTN map00860 P ferritin COG1528 Cluster_789287 V1234626 map02010 P ABC transporter COG1122 Cluster_452970 V1234627 NRTD map00910,map02010 P ABC transporter COG1116 Cluster_452972 V1234630 HISC map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01230 E Imidazole acetol-phosphate transaminase COG0079 Cluster_809197 V1234631 GLYQ map00970 J glycyl-tRNA synthetase, alpha subunit COG0752 Cluster_454989 V1234632 S peptidase family M49 0XRK4 Cluster_728219 V1234634 PQQL O Peptidase, M16 COG0612 Cluster_721595 V1234635 S NA 0ZHU9 Cluster_456930 V1234640 SPEB S peptidase C10 11SDT Cluster_669855 V1234641 L NA 0YQQ7 Cluster_456931 V1234642 CAS3 L CRISPR-Associated Helicase Cas3 COG1203 Cluster_458905 V1234644 NAGH map00051,map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 G hydrolase family 20, catalytic COG3525 Cluster_499821 V1234650 G Alpha-1,2-mannosidase COG3537 Cluster_458906 V1234651 LMRA V ABC transporter, ATP-binding protein COG1132 Cluster_579589 V1234653 M efflux transporter, rnd family, mfp subunit COG0845 Cluster_465160 V1234654 MGTA P magnesium-translocating P-type ATPase COG0474 Cluster_458907 V1234655 S NA 11MMW Cluster_800964 V1234656 PGSA map00564,map01100 I cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase COG0558 Cluster_504758 V1234660 S Na H antiporter COG2056 Cluster_665557 V1234661 S NA 0ZHU9 Cluster_800965 V1234664 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_460958 V1234665 H Thiamine monophosphate synthase/TENI COG0352 Cluster_460959 V1234667 P K -dependent Na -Ca exchanger COG0530 Cluster_460960 V1234668 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_460961 V1234669 S domain protein 0XPXI Cluster_460962 V1234670 S NA 11EHM Cluster_925485 V1234672 PFLD map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_463082 V1234676 YHCC S Radical SAM Protein COG1242 Cluster_460964 V1234677 S NA 0ZHU9 Cluster_463083 V1234681 MARC U Multiple antibiotic resistance (MarC)-related protein COG2095 Cluster_463084 V1234682 C NADH flavin oxidoreductase NADH oxidase COG1902 Cluster_463085 V1234683 LIPA map00785,map01100 H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) COG0320 Cluster_570055 V1234687 S acetyltransferase, (GNAT) family 0ZXDQ Cluster_465162 V1234691 S Membrane 0XQTX Cluster_465163 V1234692 YBBC V conserved protein UCP016719 COG3876 Cluster_465164 V1234693 N Cell surface protein 0XQ7Y Cluster_665558 V1234694 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_467242 V1234697 PCKA map00010,map00020,map00620,map00710,map01100,map01110,map01120 C Phosphoenolpyruvate Carboxylase COG1866 Cluster_471533 V1234698 QUEF map00790,map01100 S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) COG0780 Cluster_816961 V1234700 SFUM_3001 S tRNA (Guanine-N(1)-)-methyltransferase COG4752 Cluster_526124 V1234701 S NA 11EQC Cluster_469370 V1234702 G domain protein 11V8D Cluster_467244 V1234705 SP_2145 G Alpha-1,2-mannosidase COG3537 Cluster_469371 V1234708 TRAG S conjugation system ATPase, TraG family 0XSHU Cluster_610551 V1234709 P tonB-dependent Receptor COG1629 Cluster_469372 V1234710 G hydrolase, family 43 COG3507 Cluster_467245 V1234711 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_467246 V1234714 RUSA L endodeoxyribonuclease RusA COG4570 Cluster_469373 V1234715 S Pfam:YadA 0ZHSU Cluster_467247 V1234716 OCAR_7462 map00270,map00450,map01100,map01110,map01230 E Methionine synthase COG0620 Cluster_469374 V1234717 S NA 0Y8K6 Cluster_469375 V1234718 YBIT S ABC transporter, ATP-binding protein COG0488 Cluster_469376 V1234719 ISPG map00900,map01100,map01110 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) COG0821 Cluster_755024 V1234720 SPEG map00330,map01100 J acetyltransferase, (GNAT) family COG1670 Cluster_469377 V1234722 MENC map00130,map01100,map01110 M mandelate racemase muconate lactonizing COG4948 Cluster_554846 V1234723 O Band 7 protein COG0330 Cluster_471534 V1234724 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_586037 V1234726 S YitT family COG1284 Cluster_471535 V1234727 U, W Domain-Containing protein COG5295 Cluster_469379 V1234728 S NA 0ZT45 Cluster_473635 V1234732 P TonB-dependent receptor Plug 0XNPQ Cluster_473636 V1234738 YRBE Q ABC superfamily ATP binding cassette transporter permease protein COG0767 Cluster_473637 V1234740 RAGB S RagB SusD domain protein 0XZ44 Cluster_473638 V1234741 L transposase COG0675 Cluster_554847 V1234742 S Thioesterase COG5496 Cluster_475789 V1234743 S NA 0YG1I Cluster_473639 V1234744 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_473640 V1234745 HFLC O SPFH domain, Band 7 family protein COG0330 Cluster_475790 V1234746 S NA 0Y8K6 Cluster_543074 V1234747 YDCP map05120 O Peptidase, U32 family COG0826 Cluster_475791 V1234751 L site-specific recombinase, phage integrase family 0ZF8H Cluster_477983 V1234752 MREB D Rod shape-determining protein mreb COG1077 Cluster_475792 V1234755 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_475793 V1234756 NMB0459 S Filamentation induced by cAMP protein fic COG3177 Cluster_477984 V1234757 L helicase domain protein COG0553 Cluster_477985 V1234758 TGT J Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COG0343 Cluster_475794 V1234759 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_475795 V1234761 GLYQ map00970 J glycyl-tRNA synthetase, alpha subunit COG0752 Cluster_507344 V1234762 S Pfam:DUF477 COG1512 Cluster_523216 V1234764 DCM map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_494645 V1234768 K Transcriptional regulator COG3604 Cluster_477987 V1234769 LGAS_0606 S Phage Portal Protein 0XP33 Cluster_477988 V1234771 S NA 0YG6V Cluster_480387 V1234773 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_480388 V1234775 WHIA K May be required for sporulation (By similarity) COG1481 Cluster_494646 V1234777 S NA 11EKV Cluster_480390 V1234780 NAGH map00051,map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 G hydrolase family 20, catalytic COG3525 Cluster_480391 V1234781 V restriction enzyme 17GY1@proNOG Cluster_480392 V1234785 TDH G, M epimerase dehydratase COG0451 Cluster_482712 V1234789 METQ map02010 P (Lipo)protein COG1464 Cluster_482713 V1234792 S NA 11YT1 Cluster_644875 V1234793 S NA 0YU1Y Cluster_563775 V1234795 S NA 0XSGQ Cluster_705405 V1234797 S prophage pi2 protein 38 11U3I Cluster_579590 V1234799 DTD J Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) COG1490 Cluster_599688 V1234800 S major tail protein, phi13 family 11ICY Cluster_504759 V1234802 YCGM map00350,map01100,map01120 Q fumarylacetoacetate (faa) hydrolase COG0179 Cluster_485027 V1234803 S Domain of Unknown Function (DUF1080) 0YZYY Cluster_485028 V1234804 ATU2672 S ABC transporter COG2984 Cluster_728221 V1234806 YTQA S Radical SAM Protein COG1242 Cluster_485030 V1234810 M Cell wall anchor domain protein 11PS2 Cluster_487317 V1234811 YHBJ S Displays ATPase and GTPase activities (By similarity) COG1660 Cluster_487318 V1234813 MALX map00010,map00500,map02060 G PTS System COG1263 Cluster_487319 V1234814 G transporter major facilitator family protein 0XRD8 Cluster_576486 V1234815 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_669856 V1234816 P tonB-dependent Receptor 0XP2F Cluster_489665 V1234817 S NA 123SZ Cluster_489666 V1234822 CLPP map04112 O ATP-dependent Clp protease, proteolytic subunit COG0740 Cluster_489667 V1234824 S NA 11EHP Cluster_489668 V1234825 COMM O Mg chelatase subunit ChlI COG0606 Cluster_489669 V1234827 S NA 0YB9X Cluster_489670 V1234828 ARSB P Citrate transporter COG1055 Cluster_695959 V1234829 VIRE2 S Virulence-associated protein e COG5545 Cluster_586038 V1234831 NRDG O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) COG0602 Cluster_909080 V1234833 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_695960 V1234834 S NA 0YSBG Cluster_520446 V1234835 ASNA map00250,map00460,map00910,map01100,map01110,map01230 E asparagine synthetase A COG2502 Cluster_499822 V1234837 S NA 0YZMJ Cluster_492165 V1234838 CMK map00240,map00410,map00770,map01100,map01110 F Cytidine monophosphate kinase COG0283 Cluster_492167 V1234841 SPEB S peptidase C10 11SDT Cluster_579591 V1234842 S NA 0ZUR0 Cluster_494647 V1234844 NAGH map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 S K01197 hyaluronoglucosaminidase EC 3.2.1.35 0XPBQ Cluster_606894 V1234847 S interferon-induced transmembrane protein 121MN Cluster_758555 V1234848 G Alpha-1,2-mannosidase COG3537 Cluster_494650 V1234851 RLUA J Pseudouridine synthase COG0564 Cluster_494652 V1234855 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_863946 V1234864 K Transcriptional regulator, ARAC family 125DJ Cluster_859605 V1234865 P Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) COG4206 Cluster_499823 V1234866 S NA 0YZ82 Cluster_499824 V1234867 T serine threonine protein kinase COG0515 Cluster_840091 V1234868 S NA 0Y25P Cluster_499825 V1234869 UVRD2 map03420,map03430 L helicase COG0210 Cluster_502357 V1234870 OTSA map00500,map01100 G alpha-alpha-trehalose-phosphate synthase COG1877 Cluster_502358 V1234874 U, W Inherit from COG: domain protein COG5295 Cluster_824767 V1234875 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_504760 V1234877 map03440 L UvrD REP helicase COG1074 Cluster_504761 V1234878 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_563776 V1234880 CAS5D L CRISPR-associated protein 0XQ9Q Cluster_517888 V1234881 SPEB S peptidase C10 11SDT Cluster_504763 V1234884 S NA 0Y0S0 Cluster_507345 V1234887 YJGF J endoribonuclease L-psp COG0251 Cluster_573253 V1234888 map00230 F, P ppx gppa phosphatase COG0248 Cluster_734730 V1234889 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_515211 V1234890 FRUK-1 map00051 G 1-phosphofructokinase COG1105 Cluster_751571 V1234891 L integrase family 0XRS7 Cluster_560808 V1234892 U, W Inherit from COG: domain protein COG5295 Cluster_534483 V1234893 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_507346 V1234895 PLAV_1224 S NA 0ZTDK Cluster_509934 V1234896 PPC map00620,map00680,map00710,map00720,map01100,map01120 C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) COG2352 Cluster_507347 V1234897 V ABC transporter COG1132 Cluster_509935 V1234902 S tonB-dependent Receptor 0YAYV Cluster_509937 V1234904 ALDA map00010,map00040,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00640,map00903,map01100,map01110,map01120 C Dehydrogenase COG1012 Cluster_507348 V1234905 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_537379 V1234912 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_509940 V1234913 L Site-specific recombinase COG1961 Cluster_824769 V1234914 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_509941 V1234915 HSDM V Type I restriction-modification system, M subunit COG0286 Cluster_512514 V1234916 PIPD E Dipeptidase COG4690 Cluster_582837 V1234922 map00190,map00680,map01100 C ATP synthase, subunit F 124BE Cluster_546021 V1234923 S Family of unknown function (DUF490) 0Z0C5 Cluster_512516 V1234925 S membrane protein involved in aromatic hydrocarbon degradation 0YMT5 Cluster_840093 V1234927 map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_515213 V1234928 NRDB map00230,map00240,map00480,map01100,map04115 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_512517 V1234930 SERB map00260,map00680,map01100,map01120,map01230 E phosphoserine phosphatase COG0560 Cluster_515214 V1234931 YAET M outer membrane protein assembly complex, YaeT protein COG4775 Cluster_515215 V1234934 O Peptidyl-prolyl cis-trans isomerase COG0760 Cluster_515216 V1234935 VIOA map00362,map00363,map00626,map00650,map00903,map01100,map01110,map01120 E DegT DnrJ EryC1 StrS COG0399 Cluster_579592 V1234936 S NA 11JP6 Cluster_515217 V1234940 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_546022 V1234941 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_515218 V1234944 PPDK map00620,map00680,map00710,map00720,map01100,map01120 G pyruvate phosphate dikinase COG0574 Cluster_517889 V1234945 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_520447 V1234947 S Inherit from NOG: antigen PG97 COG4886 Cluster_520448 V1234948 DAPL map00300,map01100,map01110,map01230 E Aminotransferase COG0436 Cluster_517890 V1234949 SECF map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) COG0341 Cluster_797038 V1234951 Y2366 V ABC transporter, permease COG0577 Cluster_520449 V1234955 RIBBA map00740,map01100 H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) COG0807 Cluster_520450 V1234956 YBHK S UPF0052 protein COG0391 Cluster_797039 V1234957 K Inherit from COG: Transcriptional regulator COG3655 Cluster_773695 V1234960 GLNP E ABC transporter (Permease) COG0765 Cluster_520451 V1234966 S tonB-dependent receptor plug 0XNX2 Cluster_523218 V1234967 S NA 0ZTYV Cluster_523219 V1234968 S NA 123SZ Cluster_751572 V1234970 S rhodanese-like protein 0ZX1Q Cluster_848044 V1234975 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_523220 V1234978 V Mate efflux family protein COG0534 Cluster_523221 V1234980 S NA 0Y8K6 Cluster_523222 V1234981 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_644876 V1234982 S Inherit from NOG: Methyltransferase 0XSGP Cluster_526126 V1234984 RLUC J pseudouridine synthase COG0564 Cluster_526127 V1234985 HEMN map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_528882 V1234986 S tape measure domain protein 11PSY Cluster_526128 V1234987 PACL P calcium-translocating P-type ATPase COG0474 Cluster_859606 V1234989 S Ragb susd domain-containing protein 110TH Cluster_528883 V1234991 S Pfam:DUF1200 0YA60 Cluster_528884 V1234992 G transporter major facilitator family protein 0XRD8 Cluster_755025 V1234994 map00620,map00710,map01100,map01120 C Malic enzyme, N-terminal domain COG0281 Cluster_528885 V1234999 S fibronectin type III domain protein 0YCHC Cluster_531701 V1235000 BCGIA V Type II restriction modification enzyme methyltransferase COG0286 Cluster_531702 V1235001 RAGA P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_531703 V1235003 PGN_0050 S NA 0XNWW Cluster_724938 V1235004 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_582839 V1235005 BGLB map00460,map00500,map00940,map01100,map01110 G hydrolase family 3 COG1472 Cluster_606896 V1235006 M NA 0YD3K Cluster_531704 V1235007 K Transcriptional regulator, ARAC family COG2207 Cluster_531705 V1235010 LGAS_0606 S Phage Portal Protein 0XP33 Cluster_875989 V1235015 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2801 Cluster_534484 V1235017 YJJK S ATP-binding cassette protein, ChvD family COG0488 Cluster_531709 V1235018 CBIX map00860,map01100 S cobalamin (vitamin b12) biosynthesis cbix protein 0XS6H Cluster_816962 V1235019 SOJ D Chromosome Partitioning Protein COG1192 Cluster_531710 V1235020 V type I restriction enzyme COG4748 Cluster_531711 V1235021 RIBD map00740,map01100 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) COG0117 Cluster_534485 V1235022 S Inherit from COG: leucine Rich Repeat COG4886 Cluster_531712 V1235023 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_579593 V1235024 YQFA S UPF0365 protein COG4864 Cluster_534486 V1235026 E Peptidase, S9A B C family, catalytic domain protein COG1506 Cluster_534487 V1235029 SPOT map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_537380 V1235032 E peptidase, M24 COG0006 Cluster_534489 V1235034 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_648945 V1235035 M NA 0YD3K Cluster_534490 V1235036 K transcriptional regulator 11Z66 Cluster_534491 V1235037 S Auxin Efflux Carrier COG0679 Cluster_537381 V1235038 S NA 12BX4 Cluster_592700 V1235039 S NA 11VF8 Cluster_534492 V1235042 M Inherit from COG: domain protein COG4932 Cluster_537382 V1235044 BMUL_0473 S ABC transporter, permease COG4120 Cluster_537384 V1235047 POLA_2 L DNA polymerase 0XRUF Cluster_537385 V1235048 O m6 family metalloprotease domain protein COG4412 Cluster_824772 V1235058 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_540177 V1235059 CSHA map03018 L DEAD DEAH box helicase COG0513 Cluster_540181 V1235064 MUTS2 map03430 L muts2 protein COG1193 Cluster_540182 V1235065 NDVA2 V ABC transporter, ATP-binding protein COG1132 Cluster_540183 V1235066 S UbiE COQ5 family 11KJ9 Cluster_540184 V1235069 S domain protein 0XS27 Cluster_543075 V1235070 TYPA T gtp-binding protein typa COG1217 Cluster_540185 V1235072 map02010 P ABC transporter COG1122 Cluster_592701 V1235073 INSI L transposase COG2826 Cluster_540186 V1235075 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_543077 V1235079 P Voltage gated chloride channel COG0038 Cluster_543078 V1235081 S NA 0XSI9 Cluster_543079 V1235086 S Ragb susd domain-containing protein 0XSTW Cluster_543080 V1235087 PIP map00330 E Proline imino-peptidase 0XPKQ Cluster_800971 V1235088 CAS2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) COG1343 Cluster_546023 V1235090 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_546024 V1235092 TYPA T gtp-binding protein typa COG1217 Cluster_543082 V1235096 O Peptidase, M16 COG0612 Cluster_546026 V1235102 METQ2 map02010 P NLPA lipoprotein COG1464 Cluster_546027 V1235104 PYRC map00240,map01100 F Dihydroorotase COG0044 Cluster_766283 V1235105 K NUDIX domain COG0494 Cluster_549065 V1235111 PYC map00020,map00620,map00720,map01100,map01120,map01230 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) COG1038 Cluster_546028 V1235113 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_549067 V1235116 HFLC O SPFH domain, Band 7 family protein COG0330 Cluster_549069 V1235131 HBP35 S NA 0YVX1 Cluster_563778 V1235132 S The GLUG motif protein family protein 11ZVU Cluster_632949 V1235133 K transcriptional regulator 123GX Cluster_551951 V1235134 S pathogenesis 0XR1H Cluster_551954 V1235141 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_744802 V1235142 S NA 11EK1 Cluster_551955 V1235145 MSRA O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) COG0225 Cluster_653025 V1235146 RSBV T stage II sporulation protein COG1366 Cluster_551956 V1235150 map02010 P Manganese-binding protein COG0803 Cluster_554851 V1235152 HSDM V HsdM N-terminal domain COG0286 Cluster_554852 V1235153 S NA 101UU Cluster_661373 V1235154 STERM_0814 S Erf family 11TP8 Cluster_554853 V1235156 M glycosyltransferase group 2 family protein COG0463 Cluster_554854 V1235157 S NA 0ZP1D Cluster_554855 V1235159 S Possible lysine decarboxylase COG1611 Cluster_755027 V1235162 CCAN_12780 L Transposase COG1662 Cluster_557749 V1235163 FLIC map02020,map02040,map04626,map05132,map05134 N Flagellin COG1344 Cluster_836206 V1235164 S NA 0Y6BE Cluster_554856 V1235167 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_683243 V1235168 K Transcriptional regulator 0XSBF Cluster_557750 V1235169 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_657151 V1235172 S Domain of unknown function (DUF1896) 11Y7P Cluster_557751 V1235173 S Family of unknown function (DUF490) 0Z0C5 Cluster_560809 V1235174 GLYQS map00970 J Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) COG0423 Cluster_557752 V1235176 S NA 0Y4VZ Cluster_824773 V1235177 P TonB-dependent Receptor Plug Domain 0YD5U Cluster_557753 V1235178 L Dna topoisomerase COG0550 Cluster_621630 V1235182 S Capsid protein (F protein) 0YGE8 Cluster_557755 V1235186 PARB K parb-like partition protein COG1475 Cluster_560811 V1235187 G hydrolase family 43 10AED Cluster_560812 V1235189 M NA 0YD3K Cluster_755028 V1235193 S NA 0ZHU9 Cluster_665559 V1235195 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_692171 V1235196 RPSS map03010 J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) COG0185 Cluster_563779 V1235197 IADA S Isoaspartyl dipeptidase 0XNTK Cluster_563780 V1235198 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_563782 V1235203 XYLB map00040,map01100 G xylulokinase COG1070 Cluster_579594 V1235204 map02010 P periplasmic COG0803 Cluster_563783 V1235206 V N-6 DNA Methylase COG0286 Cluster_741500 V1235208 L DNA binding domain, excisionase family 11VIS Cluster_777415 V1235209 LIPA map00785,map01100 H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) COG0320 Cluster_563784 V1235210 K GntR Family Transcriptional Regulator COG2186 Cluster_579595 V1235212 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_576487 V1235213 MEXF V AcrB AcrD family multidrug resistance protein COG0841 Cluster_566969 V1235214 map02010 E ABC, transporter COG4166 Cluster_563785 V1235215 S NA 0YBZF Cluster_566970 V1235216 S Periplasmic Protein COG2859 Cluster_718275 V1235217 S AP2 domain 123DH Cluster_566971 V1235220 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0550 Cluster_566972 V1235222 SPOU J rrna methyltransferase COG0566 Cluster_566973 V1235224 O phage portal protein HK97 family COG4695 Cluster_566974 V1235225 S NA 11FZK Cluster_566975 V1235228 K, L domain protein COG0553 Cluster_566976 V1235231 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_570057 V1235232 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_570058 V1235233 S NA COG4694 Cluster_579596 V1235235 RPSM map03010 J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits COG0099 Cluster_570059 V1235241 HUTH map00340,map01100 E Histidine ammonia-lyase COG2986 Cluster_625411 V1235242 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_570060 V1235243 S NA 101UU Cluster_589340 V1235244 G transporter 0XQHZ Cluster_570061 V1235245 S Acyl-transferase 0XPHK Cluster_573256 V1235249 MURE map00300,map00550 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_573257 V1235250 ENC_23920 S Phospholipid glycerol acyltransferase COG3176 Cluster_573258 V1235251 KTRB P Potassium uptake protein COG0168 Cluster_573260 V1235255 YGDL H uba thif-type nad fad binding protein COG1179 Cluster_573261 V1235257 CSD1 L CRISPR-associated protein Csd1 family 0XPRM Cluster_800972 V1235258 S NA 0Z1V8 Cluster_573262 V1235259 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_573264 V1235264 GLGB map00500,map01100,map01110 G 1,4-alpha-glucan branching enzyme COG0296 Cluster_573265 V1235265 S NA 11EID Cluster_573266 V1235266 ACRB P heavy metal efflux pump, CzcA family COG0841 Cluster_576488 V1235269 S LRV FeS4 cluster domain protein 1769V@proNOG Cluster_576489 V1235274 ACA4 P Calcium-translocating P-type ATPase, PMCA-type COG0474 Cluster_576490 V1235275 RUMA map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_674249 V1235276 FUCU G RbsD or FucU transport COG4154 Cluster_614211 V1235278 TAL map00030,map01100,map01110,map01120,map01230 G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) COG0176 Cluster_579597 V1235279 S Nucleotidyl transferase of unknown function (DUF1814) 0XP6B Cluster_579598 V1235280 CAPD map00051,map00362,map00363,map00521,map00523,map00591,map00625,map00626,map00650,map00903,map01055,map01100,map01110,map01120 M polysaccharide biosynthesis protein COG1086 Cluster_579599 V1235283 BAPKO_0207 P Magnesium and cobalt efflux protein corC COG1253 Cluster_674251 V1235285 S Abortive infection protein AbiGII 0XQHH Cluster_576491 V1235286 YBIT S ABC transporter, ATP-binding protein COG0488 Cluster_579600 V1235287 CLPB O Chaperone COG0542 Cluster_579601 V1235289 SPOIID D SpoIID LytB domain protein COG2385 Cluster_828576 V1235291 YCCF S Membrane COG3304 Cluster_579602 V1235292 L Domain protein COG0507 Cluster_579603 V1235293 TGT J Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COG0343 Cluster_644878 V1235302 S NA 12AGZ Cluster_582842 V1235303 S Lysyl endopeptidase 1072U Cluster_582843 V1235306 NHAA map00680 P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) COG3004 Cluster_705407 V1235307 S Frg domain protein 0ZXCB Cluster_855603 V1235316 RUVC map03440 L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) COG0817 Cluster_629121 V1235317 MCRC V restriction COG4268 Cluster_586039 V1235318 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_586040 V1235319 MDH map00020,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120 C Malate dehydrogenase COG0039 Cluster_582846 V1235320 S NA 0Y8K6 Cluster_586044 V1235326 SECD map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) COG0342 Cluster_586045 V1235327 map00051 M Glycosyl transferase COG0463 Cluster_699248 V1235328 S oxidoreductase 11WN8 Cluster_586046 V1235329 U, W Pfam:YadA COG5295 Cluster_599689 V1235332 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_921531 V1235333 S RDD family 1CAZH@tenNOG Cluster_692172 V1235334 P K -dependent Na -Ca exchanger COG0530 Cluster_589342 V1235339 MUTL map03430 L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) COG0323 Cluster_589343 V1235341 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_589344 V1235345 S coat protein 114EC Cluster_687672 V1235346 ARGR K Regulates arginine biosynthesis genes (By similarity) COG1438 Cluster_592702 V1235351 V abc transporter permease protein COG0577 Cluster_592703 V1235352 CVRA P Participates in control of cell volume in low-osmolarity conditions (By similarity) COG3263 Cluster_592705 V1235356 S Membrane protein P80 1CAKS@tenNOG Cluster_592708 V1235361 P (Na H) antiporter COG0475 Cluster_596177 V1235366 V restriction 11FSE Cluster_632950 V1235367 S Addiction module antitoxin, RelB DinJ family 0XUTM Cluster_592709 V1235368 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_596178 V1235369 LPDA map00010,map00020,map00260,map00280,map00620,map01100,map01110,map01120 C dihydrolipoyl dehydrogenase COG1249 Cluster_596179 V1235372 S The GLUG motif protein family protein 11ZVU Cluster_596180 V1235373 L Reverse transcriptase (RNA-dependent DNA polymerase) COG3344 Cluster_596181 V1235375 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_813198 V1235378 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_596182 V1235379 S NA 0YZ82 Cluster_599690 V1235388 map00500,map04151,map04910 M synthase COG0438 Cluster_599691 V1235392 S NA 11TBU Cluster_596186 V1235393 S Pfam:YadA 0ZHSU Cluster_599692 V1235395 GLNS map00970,map01100 J glutaminyL-tRNA synthetase COG0008 Cluster_599693 V1235400 map02010 P Abc transporter COG1120 Cluster_603267 V1235406 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_741502 V1235409 map00040,map00500,map00531,map00860,map00944,map00983,map01100,map04142 G hydrolase family 2, sugar binding COG3250 Cluster_599695 V1235411 HEMN map00860,map01100,map01110 C coproporphyrinogen COG0635 Cluster_744803 V1235412 ASPA map00250,map00910,map01100 E Aspartate ammonia-lyase COG1027 Cluster_610554 V1235415 P Magnesium-importing ATPase COG0474 Cluster_809200 V1235416 FOPA M ompA family 10ZT3 Cluster_741503 V1235419 NRDR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) COG1327 Cluster_603269 V1235420 E Bacterial extracellular solute-binding proteins, family 5 Middle COG4166 Cluster_606898 V1235425 VEX3 V abc transporter permease protein COG0577 Cluster_606899 V1235426 DDH map00300,map01100,map01110,map01230 E Diaminopimelate dehydrogenase 0XPX2 Cluster_606900 V1235428 S Protein of unknown function (DUF3644) 176TE@proNOG Cluster_800973 V1235433 S Membrane COG2966 Cluster_606903 V1235440 MURF map00300,map00550,map01100 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) COG0770 Cluster_610556 V1235442 MGTA P Cation_ATPase_N COG0474 Cluster_606904 V1235443 XERD L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_606905 V1235444 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_824774 V1235445 YBCS S lysozyme COG3772 Cluster_610557 V1235449 S NA 0XWFB Cluster_606906 V1235450 KDSB map00540,map01100 M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) COG1212 Cluster_610559 V1235452 S Protein of unknown function DUF262 0ZMV0 Cluster_755029 V1235458 ACPP I Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) COG0236 Cluster_610561 V1235460 JAG S Single-stranded nucleic acid binding R3H domain-containing protein COG1847 Cluster_610562 V1235462 TOPA2 L Dna topoisomerase COG0550 Cluster_744804 V1235463 S Bacteriophage holin 0XWHG Cluster_718276 V1235465 COBO map00860,map01100 H Cob-I-yrinic acid a,c-diamide adenosyltransferase COG2109 Cluster_793081 V1235466 S NA 0ZHU9 Cluster_614212 V1235473 S atpase, aaa COG1373 Cluster_614213 V1235474 S Protein of unknown function DUF262 0ZMV0 Cluster_614214 V1235476 YADS S Membrane COG2860 Cluster_816965 V1235477 YLQF K Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) COG1161 Cluster_614215 V1235478 S glycosyltransferase 0Y8FN Cluster_614216 V1235479 J Glutamine amidotransferase COG2355 Cluster_614217 V1235481 FADD15 map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG1022 Cluster_614218 V1235482 BCGIA V Type II restriction modification enzyme methyltransferase COG0286 Cluster_653027 V1235484 S NA 0ZHU9 Cluster_828577 V1235485 YQFF S Metal Dependent Phosphohydrolase COG1480 Cluster_617965 V1235486 NRDR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) COG1327 Cluster_614220 V1235499 map02010 V ABC transporter COG1131 Cluster_617967 V1235500 PRDF map00330,map01100 E Proline racemase COG3938 Cluster_614221 V1235502 P tonB-dependent Receptor 0XP5Y Cluster_617968 V1235503 DPNA L helicase COG4646 Cluster_617969 V1235507 NIFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_913284 V1235511 YBCS S lysozyme COG3772 Cluster_867951 V1235516 PRFC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) COG4108 Cluster_621632 V1235519 S NA 0XRT1 Cluster_625412 V1235520 ACPS map00770 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) COG0736 Cluster_625413 V1235529 YFIO M outer membrane assembly lipoprotein yfio 0ZZRH Cluster_621635 V1235530 HEMG map00860,map01100,map01110 H Flavin containing amine oxidoreductase COG1232 Cluster_625414 V1235534 S alpha-2-macroglobulin COG2373 Cluster_625415 V1235535 S NA 0XQVA Cluster_625416 V1235536 HINDVM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_777417 V1235537 S NA 11EMA Cluster_758558 V1235539 PYRC map00240,map01100 F dihydroorotase COG0044 Cluster_625418 V1235542 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_625419 V1235543 map00051,map00520,map01100 M RmlD substrate binding domain COG1089 Cluster_625420 V1235544 DAPB map00300,map01100,map01110,map01120,map01230 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) COG0289 Cluster_625421 V1235545 map00790,map01100 H synthase COG0720 Cluster_629124 V1235546 HBP35 S NA 0YVX1 Cluster_708509 V1235548 L DNA packaging protein 123DA Cluster_641004 V1235550 S NA 0XTEF Cluster_859610 V1235551 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_820784 V1235554 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_629125 V1235556 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_629126 V1235557 YBBC V conserved protein UCP016719 COG3876 Cluster_632952 V1235558 THRA map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E homoserine dehydrogenase COG0527 Cluster_653028 V1235559 map00051,map01100,map02060 G iib component COG1445 Cluster_632953 V1235560 E peptidase, M24 COG0006 Cluster_629127 V1235561 DINB L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity) COG0389 Cluster_632954 V1235562 S Phage-associated protein 11FS5 Cluster_632955 V1235564 MENF map00130,map01053,map01100,map01110 H Isochorismate synthase COG1169 Cluster_632956 V1235567 L DNA helicase COG1112 Cluster_728227 V1235568 E peptidase COG2195 Cluster_637007 V1235569 map00240,map00450 O reductase COG0526 Cluster_632957 V1235570 HYAC C Ni Fe-hydrogenase, b-type cytochrome subunit COG1969 Cluster_734738 V1235571 map02010 P (ABC) transporter COG1840 Cluster_851831 V1235572 S SusD family 0XP8N Cluster_904955 V1235573 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_661374 V1235574 CYSK map00270,map00920,map01100,map01120,map01230 E Cysteine synthase COG0031 Cluster_632958 V1235576 L site-specific recombinase, phage integrase family 0ZJK4 Cluster_632959 V1235577 L Transposase (IS4 family 0ZJC4 Cluster_637008 V1235578 CELB map02060 G Pts system COG1455 Cluster_632960 V1235580 S NA 11NI8 Cluster_637010 V1235586 VIRE2 S Virulence-associated protein e COG5545 Cluster_637011 V1235588 PCNA map03013,map03018 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate COG0617 Cluster_641005 V1235589 PARE L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_641006 V1235592 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_880024 V1235593 map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase COG3958 Cluster_641007 V1235594 S Protein of unknown function (DUF819) COG5505 Cluster_773700 V1235596 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_715029 V1235599 HEMD map00860,map01100,map01110 H synthase COG1587 Cluster_641009 V1235601 HSDR V type I restriction-modification system COG0610 Cluster_641011 V1235603 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_644883 V1235606 S Protein of unknown function (DUF3575) 11SXP Cluster_641012 V1235611 V type I restriction-modification system, specificity subunit COG0732 Cluster_641014 V1235615 MSBA map02010 V ABC transporter, ATP-binding protein COG1132 Cluster_773701 V1235617 S NA 0ZHU9 Cluster_705409 V1235619 GLNN map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG3968 Cluster_644885 V1235621 S NA 11VCX Cluster_644886 V1235623 NIFJ map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map00910,map01100,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_648951 V1235631 OCAR_7462 map00270,map00450,map01100,map01110,map01230 E Methionine synthase COG0620 Cluster_648952 V1235633 ALGI M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_648953 V1235634 CADA P cadmium-exporting ATPase COG2217 Cluster_896350 V1235635 M peptidase M23 0XQC5 Cluster_758559 V1235638 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_648954 V1235641 L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_648955 V1235644 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_648956 V1235645 ASPC map00250,map00290,map01100,map01110,map01210,map01230 E Aminotransferase COG0436 Cluster_653029 V1235646 PEPC E aminopeptidase c COG3579 Cluster_648957 V1235647 LOLD map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_648958 V1235648 O peptidase COG1026 Cluster_653030 V1235650 S Lysyl endopeptidase 1072U Cluster_653031 V1235652 I Endonuclease Exonuclease phosphatase COG3568 Cluster_653033 V1235656 U, W Pfam:Hep_Hag COG5295 Cluster_657152 V1235660 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_653034 V1235661 NADE map00760,map01100 H Nad synthetase COG0388 Cluster_653035 V1235662 SOV S Gliding motility-related protein 0XPT8 Cluster_904957 V1235663 M peptidase M23 COG0739 Cluster_683245 V1235664 J sua5 ycio yrdc ywlc family protein COG0009 Cluster_657154 V1235668 VEX2 V abc transporter atp-binding protein COG1136 Cluster_657156 V1235672 YCEG F aminodeoxychorismate lyase COG1559 Cluster_653036 V1235673 S ATPase associated with various cellular activities COG0714 Cluster_653038 V1235675 S NA 0ZHU9 Cluster_657157 V1235676 GLYQS map00970 J Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) COG0423 Cluster_734739 V1235677 RPMB map03010 J 50s ribosomal protein l28 COG0227 Cluster_932170 V1235679 S NA 0ZHU9 Cluster_880025 V1235680 FEOB P Ferrous iron transport protein B COG1918 Cluster_657159 V1235683 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G phosphohexokinase COG0205 Cluster_657163 V1235691 S NA 11EID Cluster_789291 V1235694 BL02849 S Baat aCyl-coa thioester hydrolase COG1073 Cluster_661376 V1235697 FHUC map02010 P ABC transporter, ATP-binding protein COG1120 Cluster_657165 V1235699 PPDK map00620,map00710,map01100,map01120 G pyruvate phosphate dikinase COG0574 Cluster_657166 V1235700 P MgtE intracellular region COG2239 Cluster_789292 V1235701 RPMI map03010 J 50S ribosomal protein L35 COG0291 Cluster_661378 V1235703 PEPD E Dipeptidase COG4690 Cluster_699250 V1235705 ARCC map00230,map00330,map00910,map01120 E carbamate kinase COG0549 Cluster_665562 V1235709 CAPA M synthesis protein COG2843 Cluster_661379 V1235712 S NA 0Y0CS Cluster_665563 V1235713 CCPA K catabolite control protein a COG1609 Cluster_661380 V1235714 K Transcriptional regulator, ARAC family 11PBK Cluster_721600 V1235715 K transcriptional regulator, arac family 11ZDW Cluster_665564 V1235718 PARC L DNA topoisomerase IV, subunit A COG0188 Cluster_789293 V1235726 map02010 P ABC transporter COG1122 Cluster_665568 V1235728 M Peptidase family S41 COG0793 Cluster_665570 V1235730 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_665571 V1235731 YXKH G polysaccharide deacetylase COG0726 Cluster_665572 V1235732 S NA 0ZFM3 Cluster_665573 V1235733 S NA 0Y8K6 Cluster_665574 V1235734 map03070,map04626,map05133 M Outer membrane efflux protein COG1538 Cluster_665575 V1235737 S Organic solvent tolerance protein 0XQ3B Cluster_665579 V1235744 M Sulfatase COG1368 Cluster_665580 V1235745 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_867952 V1235746 HIT F, G Histidine triad (HIT) protein COG0537 Cluster_665581 V1235749 YAEB S Methyltransferase, YaeB family COG1720 Cluster_734740 V1235752 V Type II restriction 0YBMI Cluster_715030 V1235757 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_669863 V1235759 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_669864 V1235760 DPP map04974 E peptidase COG1506 Cluster_669866 V1235765 BATD S BatD protein 0XR99 Cluster_674254 V1235767 S Membrane COG3601 Cluster_674255 V1235768 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_678700 V1235769 YABE M domain protein COG3584 Cluster_674256 V1235770 AZL_008490 L DNA methylase COG1475 Cluster_674257 V1235771 CNA M domain protein 0ZWTG Cluster_674259 V1235773 L NA 0YZ4U Cluster_674261 V1235776 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_674262 V1235781 NQRA C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG1726 Cluster_674263 V1235783 GLDK O Sulphatase-modifying factor protein COG1262 Cluster_678705 V1235787 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_683246 V1235790 U, W Pfam:YadA COG5295 Cluster_683247 V1235791 M Sulfatase COG1368 Cluster_678707 V1235797 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_805168 V1235798 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_274825 V1023402 V abc transporter permease protein 11F1K Cluster_274826 V1023403 S NA 0ZMKZ Cluster_313432 V1023404 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_322673 V1023406 S Sortase family 11T4H Cluster_274827 V1023407 V abc transporter permease protein 11F1K Cluster_784360 V1023408 S NA 0Y2WQ Cluster_525417 V1023412 TONB M TonB family 11HUD Cluster_668870 V1023414 RPSJ map03010 J Involved in the binding of tRNA to the ribosomes (By similarity) COG0051 Cluster_799920 V1023417 YJBJ S Csbd family COG3237 Cluster_444560 V1023418 S NA 17KK7@proNOG Cluster_276151 V1023419 DPP map04974 E peptidase COG1506 Cluster_276152 V1023424 AARI_34710 L Transposase for insertion sequence 11IYJ Cluster_350220 V1023430 INFC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) COG0290 Cluster_698522 V1023432 RPSP map03010 J 30s ribosomal protein S16 COG0228 Cluster_277461 V1023435 P TonB-dependent receptor Plug 0XNPQ Cluster_278838 V1023438 RNY S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 Cluster_743938 V1023440 L Transposase COG3039 Cluster_318128 V1023442 DCM map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_277462 V1023446 RND J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) COG0349 Cluster_378476 V1023447 S inner membrane lipoprotein 17BMF@proNOG Cluster_656178 V1023452 YITW O fes assembly suf system protein COG2151 Cluster_278839 V1023453 TRPB map00260,map00400,map01100,map01110,map01230 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) COG1350 Cluster_426673 V1023454 YWLG S UPF0340 protein COG4475 Cluster_761344 V1023456 YECH S metal-binding protein 122EF Cluster_831321 V1023457 RPMD map03010 J 50S ribosomal protein L30 COG1841 Cluster_424786 V1023459 S NA 0ZHU9 Cluster_280106 V1023463 map00051,map00510,map01100 M group 2 family COG0463 Cluster_278840 V1023465 NHAP P Na H antiporter COG0025 Cluster_280108 V1023469 SSCG_04455 S Methyltransferase 0XSGP Cluster_288461 V1023471 RPOS map05111 K RNA polymerase COG0568 Cluster_280109 V1023473 S NA 11SFQ Cluster_743941 V1023476 RV3656C S NA 12265 Cluster_572450 V1023477 U type ii secretion system 123KS Cluster_324232 V1023478 L site-specific recombinase, phage integrase family 0ZJK4 Cluster_432579 V1023479 S Protein of unknown function (DUF1700) COG4709 Cluster_522529 V1023480 RV0224C map00340,map00350,map00624,map01120 S methyltransferase 0XTDB Cluster_566159 V1023481 MT0235 map00051 M glycosyl transferase group 1 COG0438 Cluster_281473 V1023482 S Relaxase mobilization nuclease 0Y9PG Cluster_660324 V1023484 S Helix-turn-helix 102I6 Cluster_566160 V1023485 S NA 11V1D Cluster_281474 V1023486 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_316586 V1023493 BIRA map00780,map01100,map02010 H biotin acetyl-CoA-carboxylase ligase COG0340 Cluster_754174 V1023494 ATPC map00190,map00195,map01100 C ATP synthase, Delta Epsilon 11YZG Cluster_720781 V1023500 RPSR map03010 J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) COG0238 Cluster_282848 V1023501 S Family of unknown function (DUF490) 0XPFA Cluster_799923 V1023510 CARA map00240,map00250,map01100 F carbamoyl-phosphate synthetase glutamine chain COG0505 Cluster_631967 V1023512 FETB map02010 P Periplasmic binding protein COG4607 Cluster_351765 V1023513 S NA 126Q7 Cluster_360090 V1023515 S NA 0ZHU9 Cluster_707777 V1023517 S Thioesterase COG0824 Cluster_581981 V1023520 QUEE map00790,map01100 H Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) COG0602 Cluster_717504 V1023521 VEX1 V ABC transporter, permease COG0577 Cluster_509303 V1023522 V type iii restriction 0ZVEY Cluster_284225 V1023523 BETT P Transporter COG1292 Cluster_285633 V1023524 EPTA S Phosphoethanolamine transferase COG2194 Cluster_475251 V1023525 INSI L transposase COG2826 Cluster_421154 V1023526 S Protein of unknown function (DUF3304) 17TD7@proNOG Cluster_285634 V1023529 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_850850 V1023532 XSEB map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1722 Cluster_285635 V1023533 HRPA L ATP-dependent helicase COG1643 Cluster_664530 V1023536 YAEI S metallophosphoesterase COG1408 Cluster_673139 V1023537 SPOVG M Could be involved in septation (By similarity) COG2088 Cluster_287060 V1023540 MNME S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 Cluster_656179 V1023541 S Protein of unknown function (DUF1462) COG4837 Cluster_750732 V1023542 NIFU O nifu domain-containing protein COG0694 Cluster_823827 V1023546 LNT M Transfers the fatty acyl group on membrane lipoproteins (By similarity) COG0815 Cluster_525419 V1023547 FXSA S cytoplasmic membrane protein 12942 Cluster_417562 V1023548 RNFE C Electron transport complex COG4660 Cluster_288462 V1023553 SP_1221 V restriction 0XQ8K Cluster_287061 V1023554 ATPH map00190,map00195,map01100 C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) COG0712 Cluster_318129 V1023555 S NA 11EJC Cluster_664531 V1023556 HIGB S this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase COG4680 Cluster_761347 V1023557 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_617002 V1023558 GAP map00010,map01100,map01110,map01120,map01230,map04066,map05010 G Glyceraldehyde-3-phosphate dehydrogenase, type I COG0057 Cluster_288463 V1023561 S NA 0Z7KE Cluster_401407 V1023562 ADK map00230,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_464692 V1023563 L NA 0YBRV Cluster_364940 V1023564 GLTK map02010,map02020 E amino acid AbC transporter COG0765 Cluster_701617 V1023565 TUSD map04122 P Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) COG1553 Cluster_288464 V1023566 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_325734 V1023567 S chlorite dismutase COG3253 Cluster_378477 V1023569 P Pfam:C4dic_mal_tran COG1275 Cluster_464693 V1023571 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_504191 V1023572 RNHA map03030 S Ribonuclease COG3341 Cluster_394351 V1023578 PHEB map00400,map01100,map01110,map01230 E Chorismate mutase COG2876 Cluster_289773 V1023579 V abc transporter permease protein 11F1K Cluster_605949 V1023584 MT0582 S conserved TRANSMEMBRANE PROTEIN 11TI5 Cluster_368324 V1023589 MAQU_3187 L Integrase catalytic subunit COG4584 Cluster_450569 V1023592 S NA 0ZNJG Cluster_324233 V1023594 CAPD map00521,map00523,map01055,map01100,map01110 M Polysaccharide biosynthesis protein COG1086 Cluster_406712 V1023595 S Inherit from NOG: antigen PG97 COG4886 Cluster_673140 V1023598 METX map00270,map00920,map01100 E Homoserine O-trans-acetylase COG2021 Cluster_581982 V1023600 YIAV V secretion protein, HlyD family COG1566 Cluster_683251 V1235801 S NA 11JP6 Cluster_683253 V1235805 S Membrane 0XQXB Cluster_683254 V1235808 S fad dependent oxidoreductase COG2509 Cluster_844136 V1235809 S NA 0ZHU9 Cluster_755032 V1235811 S NA 0ZHU9 Cluster_715031 V1235816 S NA 0ZHU9 Cluster_687676 V1235817 S NA 0YX7E Cluster_687677 V1235818 map00511,map00520,map01110,map04142 G hydrolase family 2, sugar binding COG3250 Cluster_867953 V1235820 NTPG map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG1436 Cluster_687679 V1235824 FBP map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120 G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 COG3855 Cluster_687682 V1235830 L site-specific recombinase, phage integrase family 11IW4 Cluster_793083 V1235833 T UspA domain-containing protein COG0589 Cluster_715032 V1235839 VEX3 V abc transporter permease protein COG0577 Cluster_692174 V1235840 FADD map00071,map01100,map03320,map04146,map04920 I AMP-binding enzyme COG1022 Cluster_687683 V1235842 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_844137 V1235845 MUTY map03410 L a g-specific adenine glycosylase COG1194 Cluster_687684 V1235847 S OmpA family 11HEJ Cluster_692177 V1235848 V Type I restriction enzyme R protein N terminus (HSDR_N) COG0610 Cluster_797045 V1235849 YHGE S domain protein COG1511 Cluster_692178 V1235850 EXBD U Biopolymer transport protein exbD tolR 11TA0 Cluster_728230 V1235851 YHFW map00030,map00230 G Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) COG1015 Cluster_705411 V1235859 S outer membrane lipoprotein carrier protein 11YKN Cluster_50576 V1235868 V N-6 DNA Methylase COG0286 Cluster_182993 V1235869 V restriction 11FSE Cluster_46922 V1235870 map03420,map03430 L UvrD REP helicase COG0210 Cluster_531713 V1235871 L Integrase COG0582 Cluster_152891 V1235873 V type I restriction modification COG0732 Cluster_75168 V1235874 S Bacteriophage peptidoglycan hydrolase 0ZNE8 Cluster_504765 V1235878 SP_1730 S Membrane COG3610 Cluster_610565 V1235880 S Pfam:DUF2825 17MFU@proNOG Cluster_363582 V1235883 map04112 L DNA methylase N-4 N-6 COG0863 Cluster_190753 V1235884 DCM map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_44837 V1235885 V ATPase associated with various cellular activities aaa_5 COG1401 Cluster_112771 V1235886 V restriction endonuclease 0Z1AJ Cluster_785290 V1235909 S Phosphotransferase enzyme family 0Y5XC Cluster_236106 V1235911 FLIC map02020,map02040,map04626,map05132,map05134 N Flagellin COG1344 Cluster_262980 V1235912 FLIC map02020,map02040,map04626,map05132,map05134 N Flagellin COG1344 Cluster_81754 V1235913 ATPA map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_805171 V1235919 BL03502 O phage portal protein HK97 family COG4695 Cluster_56249 V1235922 S NA 0XSPS Cluster_69262 V1235926 U, W Pfam:YadA COG5295 Cluster_741508 V1235937 MUTG map02010 S ABC transporter 11QI3 Cluster_692181 V1235938 S NA 11T0G Cluster_648959 V1235943 RPSH map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) COG0096 Cluster_156110 V1235947 map02020,map02030 S Methyl-accepting chemotaxis protein (MCP) signalling domain COG0840 Cluster_112042 V1235951 U, W Pfam:YadA COG5295 Cluster_715034 V1235967 map02040 S anti-sigma28 factor FlgM 122GJ Cluster_257739 V1235979 S NA 0XQTH Cluster_477990 V1235996 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_576492 V1235998 K ParB domain protein nuclease COG1475 Cluster_621636 V1235999 S NA 0XWWF Cluster_669867 V1236002 S NA 122IS Cluster_573267 V1236011 HSDM V type I restriction-modification system COG0286 Cluster_245171 V1236015 K Transcriptional regulator 0Y1S3 Cluster_904965 V1236020 RPSG map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) COG0049 Cluster_875996 V1236022 S NA 0ZHU9 Cluster_344139 V1236030 PRS map00030,map00230,map01100,map01110,map01120,map01230 E, F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_271058 V1236040 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_273726 V1236043 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_570062 V1236049 ATPF map00190,map00195,map01100 M Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) 11RTE Cluster_599696 V1236059 S NA 17D58@proNOG Cluster_832318 V1236072 RPLM map03010 J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) COG0102 Cluster_551957 V1236077 S NA 0ZHU9 Cluster_350583 V1236086 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_341031 V1236089 ARCC map00230,map00330,map00910,map01120 E carbamate kinase COG0549 Cluster_341032 V1236090 SECF map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) COG0341 Cluster_344140 V1236093 S Uncharacterized protein conserved in bacteria (DUF2225) COG1655 Cluster_603270 V1236097 LPXA map00540,map01100 M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) COG1043 Cluster_358773 V1236100 V ABC transporter, ATP-binding permease protein COG1132 Cluster_355416 V1236105 MIAB J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) COG0621 Cluster_358774 V1236116 S Minor capsid protein 0Y58E Cluster_363583 V1236129 S NA 0ZHU9 Cluster_554857 V1236130 CCA map03013,map03018 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate COG0617 Cluster_370356 V1236137 YXCA I coA-substrate-specific enzyme activase COG3581 Cluster_724941 V1236138 C nitrogenase COG2710 Cluster_373600 V1236143 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_389436 V1236149 S Abortive infection protein AbiGI 11WH3 Cluster_579604 V1236151 GLF M udp-galactopyranose mutase COG0562 Cluster_809206 V1236153 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_392985 V1236155 O peptidase COG1026 Cluster_554858 V1236159 YADS S Membrane COG2860 Cluster_384130 V1236160 HSLO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) COG1281 Cluster_384131 V1236161 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_385905 V1236165 S NA 128RV Cluster_391169 V1236173 S ATPase (AAA COG1373 Cluster_755035 V1236188 G Major Facilitator superfamily 16RT8@proNOG Cluster_711643 V1236190 S NA 0ZHU9 Cluster_401823 V1236193 S Hydrolase COG0561 Cluster_403596 V1236195 S pathogenesis 0XR1H Cluster_403597 V1236200 WECG M Glycosyl transferase, wecb taga cpsf family COG1922 Cluster_485032 V1236201 S NA 0ZHU9 Cluster_440999 V1236207 S Collagen triple helix repeat 0YHFV Cluster_407082 V1236214 PARC L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_589348 V1236216 S Pfam:YadA 126HB Cluster_408856 V1236217 RNZ map03013 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) COG1234 Cluster_410711 V1236220 S Integral membrane protein CcmA involved in cell shape determination 0XUSB Cluster_528887 V1236225 L NUDIX domain 11W54 Cluster_414401 V1236228 PPC map00620,map00680,map00710,map00720,map01100,map01120 C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) COG2352 Cluster_419754 V1236237 U, W Pfam:YadA COG5295 Cluster_755036 V1236241 FEOB P Ferrous iron transport protein b COG0370 Cluster_797055 V1236248 CMK map00240,map00410,map00770,map01100,map01110 F Cytidine monophosphate kinase COG0283 Cluster_427127 V1236250 VEX1 V ABC transporter, permease COG0577 Cluster_557756 V1236256 OLIA S Oligopeptide transporter, Opt family COG1297 Cluster_832320 V1236257 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_489672 V1236260 S Radical SAM superfamily COG0641 Cluster_456933 V1236270 UDK map00240,map00983,map01100 F uridine kinase COG0572 Cluster_844140 V1236274 J RNA methyltransferase COG2265 Cluster_452973 V1236285 S tail tape measure protein COG5280 Cluster_452974 V1236286 NTH map03410 L endonuclease III COG0177 Cluster_454990 V1236290 FBP map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120 G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 COG3855 Cluster_458909 V1236292 CLPB O Chaperone protein ClpB COG0542 Cluster_454991 V1236293 S NA 0YT9M Cluster_463086 V1236305 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_463087 V1236307 V Mate efflux family protein COG0534 Cluster_632964 V1236308 S NA 0ZHU9 Cluster_708512 V1236310 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_471536 V1236312 PPDK map00620,map00710,map01100,map01120 G pyruvate phosphate dikinase COG0574 Cluster_467250 V1236315 HBDA map00360,map00362,map00650,map01100,map01120 C 3-hydroxybutyryl-CoA dehydrogenase COG1250 Cluster_828585 V1236319 COMEB map00240,map01100 F deaminase COG2131 Cluster_469380 V1236322 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_755038 V1236340 S NA 0ZHU9 Cluster_477991 V1236342 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_482714 V1236357 ULAA map00053,map01100,map01120,map02060 G PTS system ascorbate-specific transporter subunit IIC COG3037 Cluster_678710 V1236359 S NA 0ZHU9 Cluster_549070 V1236367 DCTP C symporter COG1301 Cluster_494655 V1236369 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_766289 V1236378 S toxin secretion phage lysis holin COG4824 Cluster_502360 V1236389 YNHI map00900,map01110 S heptaprenyl diphosphate synthase component I COG4769 Cluster_494656 V1236391 Q AMP-binding enzyme COG0318 Cluster_751580 V1236397 S NA 0YSBG Cluster_499827 V1236398 XASA E amino acid COG0531 Cluster_504766 V1236405 SUN J ribosomal RNA small subunit methyltransferase COG0144 Cluster_641016 V1236408 K Transcriptional regulator, TetR family 11S7S Cluster_502361 V1236409 FLIC map02020,map02040,map04626,map05132,map05134 N Flagellin COG1344 Cluster_502362 V1236411 NPDA map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_509943 V1236413 YIEG2 S Xanthine uracil vitamin C permease COG2252 Cluster_687686 V1236414 S NA 0ZHU9 Cluster_504767 V1236418 COBW S CobW P47K family protein COG0523 Cluster_502363 V1236420 COAX map00770,map01100 K Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) COG1521 Cluster_504768 V1236424 S Helix-turn-helix 0XT0B Cluster_504769 V1236428 SCLAV_3941 O Band 7 protein COG0330 Cluster_507349 V1236429 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_507350 V1236430 S Bacteriophage Gp15 protein 11NHP Cluster_517891 V1236432 ACPS map00770 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) COG0736 Cluster_509944 V1236438 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_509945 V1236441 ISPE map00900,map01100,map01110 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COG1947 Cluster_721605 V1236444 map02010 P ABC transporter COG1122 Cluster_515219 V1236456 CHEX-4 S NA 11NTE Cluster_517892 V1236463 T Metal Dependent Phosphohydrolase COG2206 Cluster_517893 V1236464 MURE map00300,map00550,map01100 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_520454 V1236481 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_526130 V1236491 map02020 T Histidine kinase COG0642 Cluster_528889 V1236505 SGAT map00053,map01100,map01120,map02060 G PTS system ascorbate-specific transporter subunit IIC COG3037 Cluster_528890 V1236509 HEMZ map00860,map01100,map01110 H coproporphyrinogen III oxidase COG0635 Cluster_531715 V1236515 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_531716 V1236518 MGT map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_579605 V1236520 GLPA map00564,map00730 C fad dependent oxidoreductase COG0579 Cluster_534493 V1236524 PDTAS T Histidine kinase COG3920 Cluster_534494 V1236528 RLUC J pseudouridine synthase COG0564 Cluster_537389 V1236536 S HTH_XRE 0Y5DE Cluster_766291 V1236537 COMA map02010,map02020 V Abc transporter COG2274 Cluster_805184 V1236541 CG1374 S Domain of unknown function DUF77 COG0011 Cluster_731539 V1236547 YLME F alanine racemase domain protein COG0325 Cluster_711645 V1236558 S NA 0ZXW8 Cluster_738101 V1236562 S NA 0ZHU9 Cluster_586048 V1236565 O peptidase COG1026 Cluster_554859 V1236570 RPON map02020,map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG1508 Cluster_546031 V1236571 S Membrane 0ZWF2 Cluster_546032 V1236574 GLTS E Sodium Glutamate Symporter COG0786 Cluster_549072 V1236575 GPMB map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_549073 V1236579 RLMH S Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) COG1576 Cluster_748165 V1236580 MAPA map00500,map01100 G hydrolase family 65, central catalytic COG1554 Cluster_789302 V1236584 RECR map03440 L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) COG0353 Cluster_554860 V1236589 LDH map00010,map00270,map00620,map00640,map01100,map01110,map01120 C L-lactate dehydrogenase COG0039 Cluster_596189 V1236590 M Glycosyl transferase, family 2 COG0463 Cluster_855617 V1236593 S fad dependent oxidoreductase COG2509 Cluster_554861 V1236595 P TonB-dependent Receptor Plug Domain protein COG4771 Cluster_557758 V1236601 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_557759 V1236605 V Mate efflux family protein COG0534 Cluster_560815 V1236608 MALL map00052,map00500,map01100 G trehalose-6-phosphate hydrolase (EC 3.2.1.93) COG0366 Cluster_687687 V1236618 MGTE P magnesium transporter COG2239 Cluster_560816 V1236621 M Glycosyl transferase, family 2 COG0463 Cluster_560817 V1236622 PLSY map00561,map00564,map01100 S Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) COG0344 Cluster_738102 V1236628 MRNC S Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) COG1939 Cluster_573270 V1236629 map00030,map00260,map00680,map01100,map01120,map01230 C Dehydrogenase COG0111 Cluster_718280 V1236633 S NA 0ZHU9 Cluster_570063 V1236641 YBIW map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_617976 V1236653 GLNP map02010 E amino acid AbC transporter COG0765 Cluster_576493 V1236656 JAG S Single-stranded nucleic acid binding R3H domain-containing protein COG1847 Cluster_573272 V1236659 S NA 0ZHU9 Cluster_576494 V1236668 FEOB P Ferrous iron transport protein b COG0370 Cluster_579607 V1236678 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_582848 V1236681 K Transcriptional regulator, ARAC family COG2207 Cluster_820799 V1236685 K HTH_XRE 0XUC3 Cluster_589349 V1236689 PBUG S Xanthine uracil vitamin C permease COG2252 Cluster_589350 V1236692 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_632965 V1236693 S NA 0XP9D Cluster_625424 V1236695 map02010 P Cobalt transport protein COG0619 Cluster_695966 V1236696 S NA 0ZHU9 Cluster_586050 V1236698 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_711647 V1236701 GLYQ map00970 J glycyl-tRNA synthetase, alpha subunit COG0752 Cluster_816970 V1236704 S NA 0ZHU9 Cluster_592712 V1236705 P TonB-dependent Receptor Plug Domain protein COG4771 Cluster_724944 V1236707 YLQF K Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) COG1161 Cluster_592713 V1236716 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_592714 V1236719 ASNB map00250,map00910,map01100,map01110,map01120 E asparagine synthetase COG0367 Cluster_603271 V1236725 GLNP E glutamine ABC transporter, permease protein COG0765 Cluster_596190 V1236728 TGT J Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COG0343 Cluster_599698 V1236732 P CBS domain COG1253 Cluster_599699 V1236734 ECFT map02010 P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) COG0619 Cluster_748166 V1236735 S SCP-2 sterol transfer family 0Z02K Cluster_617977 V1236737 ADDA L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation COG1074 Cluster_797061 V1236745 NADE map00760,map01100 H NAD synthetase COG0388 Cluster_599701 V1236749 SCPB K Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) COG1386 Cluster_606908 V1236764 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_738105 V1236769 YCHF J gtp-binding protein COG0012 Cluster_832327 V1236773 S NA 0ZHU9 Cluster_661385 V1236776 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_610567 V1236778 map02010 P ABC transporter COG1122 Cluster_610569 V1236784 S NA 0YG6V Cluster_614223 V1236785 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_610570 V1236787 L Domain protein COG0507 Cluster_617979 V1236808 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_617980 V1236810 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_617981 V1236814 RBSC-2 S ABC transporter permease COG1079 Cluster_629131 V1236816 S NA 0ZHU9 Cluster_644893 V1236817 QUED map00790,map01100 H 6-carboxy-5,6,7,8-tetrahydropterin synthase COG0720 Cluster_621637 V1236818 S Putative cell wall binding repeat 0YEGX Cluster_621638 V1236819 map02010 V ABC transporter, ATP-binding protein COG1131 Cluster_621640 V1236824 SP_0483 map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_683256 V1236826 S NA 0ZD8I Cluster_657168 V1236827 GAPA map00010,map01100,map01110,map01120,map01230,map04066,map05010 G Glyceraldehyde-3-phosphate dehydrogenase, type I COG0057 Cluster_625428 V1236833 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_692185 V1236835 FTSE map02010 D Cell division ATP-binding protein ftsE COG2884 Cluster_625429 V1236836 MRCB map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_773704 V1236842 CKL_1868 S NA 0XRCN Cluster_625430 V1236844 S ATPase (AAA COG1373 Cluster_629132 V1236845 PURA map00230,map00250,map01100 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis COG0104 Cluster_629133 V1236847 PSPA M choline binding protein COG5263 Cluster_669868 V1236852 S mobilization protein 11J0G Cluster_632967 V1236856 CAFA map03018 J ribonuclease COG1530 Cluster_632968 V1236857 NRDE map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_728235 V1236860 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_632969 V1236861 WCFS M Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase COG2148 Cluster_632971 V1236872 YCGA S c4-dicarboxylate anaerobic carrier COG1288 Cluster_641021 V1236888 S NA 0ZHU9 Cluster_641022 V1236889 EFP J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) COG0231 Cluster_644894 V1236892 YBIP S Sulfatase COG2194 Cluster_687689 V1236896 map00270,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01230 E Aminotransferase class i COG1448 Cluster_641023 V1236902 YFMR S ABC transporter, ATP-binding protein COG0488 Cluster_871907 V1236903 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_731542 V1236906 MTAD F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) COG0402 Cluster_766297 V1236909 ISPG map00900,map01100,map01110 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) COG0821 Cluster_770027 V1236912 GDHA map00250,map00330,map00471,map00910,map01100,map04964 E Glutamate dehydrogenase COG0334 Cluster_674271 V1236917 METQ map02010 P (Lipo)protein COG1464 Cluster_896368 V1236928 DNAG map03030 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 Cluster_653041 V1236930 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_648965 V1236931 K Transcriptional regulator (LacI family 11MHG Cluster_648966 V1236935 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_828590 V1236936 HSDM V type I restriction-modification system COG0286 Cluster_648967 V1236937 map02010 P Cobalt transport protein COG0619 Cluster_653042 V1236942 OPPA E ABC transporter COG0747 Cluster_738107 V1236944 GPMA map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0588 Cluster_653043 V1236947 S Tetratricopeptide repeat protein 11J0I Cluster_718282 V1236955 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_657169 V1236956 S NA 123X9 Cluster_657172 V1236965 SGBH map00030,map00040,map00053,map00680,map01100,map01120,map01230 G decarboxylase COG0269 Cluster_657173 V1236966 CADA P Cadmium-exporting ATPase COG2217 Cluster_781171 V1236969 RPLN map03010 J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) COG0093 Cluster_692187 V1236990 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_669869 V1236991 PHOB map02020 T Two component transcriptional regulator, winged helix family COG0745 Cluster_711650 V1236993 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_674272 V1236999 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_669870 V1237001 TIG O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COG0544 Cluster_674273 V1237003 BIOA map00780,map01100 H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) COG0161 Cluster_678713 V1237010 U, W surface protein COG5295 Cluster_678714 V1237011 PBP2A map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_699253 V1237014 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_744811 V1237015 YLXM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) COG2739 Cluster_781173 V1237018 S NA 0ZHU9 Cluster_687691 V1237024 VORB map00020,map00280,map00720,map01100,map01120 C Ferredoxin COG0674 Cluster_687692 V1237026 YLOV S dak2 domain fusion protein ylov COG1461 Cluster_755043 V1237028 ADDB L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination COG3857 Cluster_683260 V1237030 ARGG map00250,map00330,map01100,map01110,map01230 E Citrulline--aspartate ligase COG0137 Cluster_683261 V1237032 S Family of unknown function (DUF490) 0ZVTR Cluster_683262 V1237033 CAH map00910 P Carbonate dehydratase COG0288 Cluster_692188 V1237042 UDP map00230 S phosphorylase 11F11 Cluster_692190 V1237050 TRXB map00240,map00450 C ferredoxin--nadp reductase COG0492 Cluster_71237 V1237067 SP_1529 M Polysaccharide Biosynthesis Protein COG2244 Cluster_344141 V1237068 F Nudix family COG1051 Cluster_449057 V1237069 S MutT NUDIX family protein 11JZT Cluster_120625 V1237071 map02020 T Histidine kinase COG2972 Cluster_126104 V1237073 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_243893 V1237074 S Abi-like protein 11VSQ Cluster_528892 V1237075 SP_0161 K, T lytTr DNA-binding domain protein COG3279 Cluster_245172 V1237076 map02010 S ABC transporter COG4152 Cluster_318447 V1237077 S ABC-2 type transporter 11FXW Cluster_637016 V1237078 S acetyltransferase 11FF5 Cluster_219634 V1237079 ADD map00230,map01100,map05340 F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) COG1816 Cluster_423407 V1237080 PLNI S CAAX amino terminal protease family 0XW1D Cluster_271059 V1237081 METQ map02010 P Lipoprotein COG1464 Cluster_90913 V1237083 map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020 C fumarate reductase succinate dehydrogenase flavoprotein domain protein COG1053 Cluster_28255 V1237084 MALZ map00052,map00500,map01100 G Alpha-glucosidase COG1501 Cluster_385907 V1237085 COMB map02020,map03070,map05133 U Transport protein ComB 0XX01 Cluster_107057 V1237086 SP_0145 G Major Facilitator COG0477 Cluster_198902 V1237091 BL00144 L Transposase COG2801 Cluster_551959 V1237092 G Major Facilitator Superfamily 11M79 Cluster_718284 V1237093 G Major Facilitator Superfamily 11M79 Cluster_425206 V1237094 G Major Facilitator Superfamily 11M79 Cluster_234905 V1237095 BSH map00120,map00121,map01100 M Choloylglycine hydrolase COG3049 Cluster_125413 V1237096 PEPC E aminopeptidase c COG3579 Cluster_284494 V1237097 MORA C Aldo keto reductase COG0656 Cluster_186486 V1237098 POTD map02010 E ABC transporter COG0687 Cluster_148093 V1237099 LYTF M defense response to bacterium COG1705 Cluster_433005 V1237100 RPOE map00230,map00240,map01100,map03020 K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity) COG3343 Cluster_132652 V1237101 PBUX F permease COG2233 Cluster_582849 V1237102 S surface protein 11NE4 Cluster_7573 V1237103 BGLF map00010,map00500,map00520,map02060 G pts system COG2190 Cluster_184697 V1237104 COMGA U Competence protein COG2804 Cluster_344142 V1237105 ATPB map00190,map00195,map01100 C it plays a direct role in the translocation of protons across the membrane (By similarity) COG0356 Cluster_762340 V1237106 ATPE map00190,map00195,map01100 C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) COG0636 Cluster_230103 V1237107 ATPG map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) COG0224 Cluster_98968 V1237108 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_345760 V1237109 RSUA J Pseudouridine synthase COG1187 Cluster_97360 V1237110 HSDM V type I restriction-modification system COG0286 Cluster_98969 V1237111 HSDS V restriction modification system DNA specificity domain COG0732 Cluster_68567 V1237112 S NA 124H4 Cluster_37492 V1237113 Y0750 S Conserved Protein COG1479 Cluster_61276 V1237114 MTLA map00051,map02060 G PTS system mannitol-specific COG2213 Cluster_141270 V1237116 AMT P ammonium transporter 0XNMH Cluster_280379 V1237117 K Transcriptional regulator 0Y1S3 Cluster_109434 V1237119 L transposase COG0675 Cluster_441000 V1237120 S (LipO)protein COG3212 Cluster_121394 V1237121 KINE T sensor protein 0XNMH Cluster_116998 V1237123 S NA 120ST Cluster_310743 V1237124 S NA 120ST Cluster_884207 V1237125 E Peptidase family M20/M25/M40 COG2195 Cluster_299475 V1237126 S ABC superfamily ATP binding cassette transporter, permease 0YYAC Cluster_147294 V1237127 G Major Facilitator COG0477 Cluster_84286 V1237128 S c4-dicarboxylate anaerobic carrier COG1288 Cluster_563787 V1237130 YPHI S Antibiotic biosynthesis monooxygenase COG1359 Cluster_67892 V1237131 MNOD_0308 L Transposase COG3666 Cluster_168539 V1237132 CFA M cyclopropane-fatty-acyl-phospholipid synthase COG2230 Cluster_400041 V1237133 PLSC map00561,map00564,map01100 I Acyl-transferase COG0204 Cluster_347351 V1237134 SRTA M (sortase) family COG3764 Cluster_29573 V1237135 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 Cluster_560818 V1237138 GALU map00040,map00052,map00500,map00520,map01100,map01110 M UTP-glucose-1-phosphate uridylyltransferase COG1210 Cluster_269754 V1237139 S Membrane 11TU2 Cluster_101145 V1237140 CPS1C M polysaccharide biosynthesis protein COG2244 Cluster_310745 V1237142 S biosynthesis protein 0XQI4 Cluster_294039 V1237143 RFBF M Glycosyl transferase, family 2 COG1216 Cluster_186487 V1237144 WBBK M glycosyl transferase COG0438 Cluster_429022 V1237145 WBBJ M lipopolysaccharide biosynthesis O-acetyl transferase COG0110 Cluster_213829 V1237146 S NA 11JM6 Cluster_407083 V1237147 S NA 0Y2WH Cluster_144978 V1237148 LYTR K TRANSCRIPTIONal COG1316 Cluster_56504 V1237149 PEPF E Oligoendopeptidase f COG1164 Cluster_171155 V1237151 MNAA map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_423408 V1237152 LEMA S LemA family COG1704 Cluster_904982 V1237153 STRIC_0432 L Transposase (IS4 family 11HCS Cluster_215009 V1237154 CAH map00311 Q acetyl xylan esterase COG3458 Cluster_70892 V1237155 OPPA map02010 E Extracellular solute-binding protein, family 5 COG4166 Cluster_460966 V1237157 WZX M polysaccharide biosynthesis protein COG2244 Cluster_124756 V1237158 MINF_2016 L transposase COG0675 Cluster_579608 V1237159 S Helix-turn-helix COG3600 Cluster_54536 V1237161 OPPA E ABC transporter COG0747 Cluster_96815 V1237162 OPPA E ABC transporter COG0747 Cluster_231280 V1237163 OPPB E, P Oligopeptide ABC transporter, permease protein AppB COG0601 Cluster_724947 V1237164 SP_1473 S UPF0291 protein COG4224 Cluster_781175 V1237165 YNEF S UPF0154 protein COG3763 Cluster_56250 V1237166 MDLB map02010 V ABC transporter COG1132 Cluster_60390 V1237167 OPPA E ABC transporter COG0747 Cluster_39480 V1237168 S NA 11NI8 Cluster_653046 V1237169 SP_0686 S bacteriocin-associated integral membrane protein COG4652 Cluster_76098 V1237170 V (ABC) transporter COG2274 Cluster_345761 V1237171 METI map02010 P ABC transporter, permease COG2011 Cluster_193490 V1237172 METN map02010 P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COG1135 Cluster_226637 V1237173 METQ map02010 P Lipoprotein COG1464 Cluster_29444 V1237174 YFGQ P Cation-transporting atpase COG0474 Cluster_232444 V1237175 THYA map00240,map00670,map01100 F Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) COG0207 Cluster_391170 V1237176 YBHL S Membrane COG0670 Cluster_146519 V1237177 LCTO map00620,map01100 C Dehydrogenase COG1304 Cluster_275081 V1237178 STRIC_0432 L Transposase (IS4 family 11HCS Cluster_65396 V1237180 S Uncharacterized conserved protein (DUF2075) 0ZN8Y Cluster_43707 V1237181 SACB map00500,map01100,map02020 G levansucrase EC 2.4.1.10 0XR0E Cluster_586051 V1237182 S conjugative transposon protein 11JUF Cluster_103433 V1237185 PTCC map02060 G pts system COG1455 Cluster_24283 V1237186 S NA 0XSPS Cluster_68 V1237187 S NA 120ST Cluster_762341 V1237188 S NA 0ZHU9 Cluster_231281 V1237189 NANA map00300,map00520,map01100,map01110,map01120,map01230 E dihydrodipicolinate COG0329 Cluster_762342 V1237190 V Restriction modification system DNA (Specificity COG0732 Cluster_144221 V1237191 HSDS V Restriction modification system DNA (Specificity COG0732 Cluster_467251 V1237195 S NA 11GVV Cluster_526131 V1237196 S Pfam:Phage_QLRG 0XZ9J Cluster_333563 V1237197 YBBB S integral membrane protein COG3548 Cluster_272393 V1237198 K transcriptional regulator 11X9R Cluster_526132 V1237199 SP_0161 K, T lytTr DNA-binding domain protein COG3279 Cluster_303685 V1237201 SGR_50T map00051,map00061,map00363,map00591,map00625,map00650,map00780,map01040,map01100,map01120 S Short-chain dehydrogenase reductase Sdr 0XRQC Cluster_22354 V1237202 PRIA map03440 L Primosomal protein n' COG1198 Cluster_147295 V1237203 AROE map00400,map01100,map01110,map01230 E shikimate COG0169 Cluster_102803 V1237204 MURE map00300,map00550 M mur ligase COG0769 Cluster_599702 V1237205 map03070 S NA 122A7 Cluster_141271 V1237206 MOD map00340,map00350,map00624,map01120 L DNA methylase COG2189 Cluster_512518 V1237207 YAFP L acetyltransferase 11TW4 Cluster_773708 V1237209 MOD L DNA methylase COG2189 Cluster_49585 V1237219 OPPD map02010 S ABC transporter COG1123 Cluster_434924 V1237220 V abc transporter COG1132 Cluster_158696 V1237221 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_210481 V1237222 K Transcriptional regulator COG1609 Cluster_515220 V1237225 WECD K acetyltransferase COG0454 Cluster_410712 V1237226 S had-superfamily hydrolase, subfamily ia, variant COG1011 Cluster_3014 V1237227 APRX O Alkaline serine protease COG1404 Cluster_896369 V1237228 L Pfam:Transposase_9 11MXK Cluster_382363 V1237229 T Transcriptional regulator, Crp Fnr family COG0664 Cluster_89977 V1237230 ZWF map00030,map00480,map01100,map01110,map01120 G glucose-6-phosphate 1-dehydrogenase COG0364 Cluster_21143 V1237231 OATA I Acyl-transferase COG1835 Cluster_53049 V1237232 S Prophage Lp2 protein 4 11JSF Cluster_56505 V1237236 V abc transporter COG1132 Cluster_144222 V1237242 HSDS V specificity COG0732 Cluster_112043 V1237245 P Chloride channel COG0038 Cluster_121395 V1237247 VEX1 V ABC transporter, permease COG0577 Cluster_25704 V1237250 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG2812 Cluster_277718 V1237251 RELA2 S RelA SpoT domain-containing protein COG2357 Cluster_24468 V1237252 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_96297 V1237253 MVAA map00900,map01100,map01110,map04976 I hydroxymethylglutaryL-CoA reductase COG1257 Cluster_125414 V1237254 MVAS map00072,map00280,map00650,map00900,map01100,map01110 I Hydroxymethylglutaryl-CoA synthase COG3425 Cluster_31187 V1237255 S NA 11VK0 Cluster_291305 V1237257 D YhjQ protein COG1192 Cluster_362016 V1237259 S CAAX amino terminal protease family protein 0XUJM Cluster_20081 V1237261 L Topoisomerase COG0550 Cluster_162892 V1237263 MALL map00500,map01100 G Oligo-1-6-glucosidase COG0366 Cluster_17144 V1237264 XYLS map00052,map00500,map01100 G hydrolase, family 31 COG1501 Cluster_3692 V1237265 U, W Inherit from COG: domain protein COG5295 Cluster_467252 V1237266 S NA 11GVV Cluster_1597 V1237267 S NA 101UU Cluster_217341 V1237269 MDLB map02010 V ABC transporter COG1132 Cluster_661388 V1237270 RPLO map03010 J Binds to the 23S rRNA (By similarity) COG0200 Cluster_272394 V1237271 MTSC map02010 P ABC transporter COG1108 Cluster_375312 V1237272 PEPN E aminopeptidase COG0308 Cluster_2240 V1237273 S NA 101UU Cluster_116296 V1237274 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_186488 V1237276 S Toprim domain protein 0XSQN Cluster_23576 V1237278 S Inherit from NOG: DNA repair protein 0XQPN Cluster_285946 V1237279 SUHB map00521,map00562,map01100,map01110,map04070 G inositol monophosphatase COG0483 Cluster_17811 V1237280 THIC map00730,map01100 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) COG0422 Cluster_427128 V1237281 DICA K Bacteriophage CI repressor helix-turn-helix domain COG1396 Cluster_33877 V1237282 map00550,map01100 M glycosyl transferase, family 51 COG0744 Cluster_291306 V1237283 K Transcriptional regulator 0Y1S3 Cluster_76099 V1237284 map02010 V ABC transporter COG1132 Cluster_199900 V1237285 S ApbE family 11H27 Cluster_260368 V1237287 GLNQ map02010,map02020 E (ABC) transporter COG1126 Cluster_47698 V1237289 RGPF M Rhamnan synthesis protein F COG3754 Cluster_220820 V1237290 M Glycosyl transferase, family 2 COG1216 Cluster_373601 V1237291 S FMN_bind 12BR0 Cluster_62377 V1237296 S Inherit from NOG: LPXTG-motif cell wall anchor domain protein 0YEBJ Cluster_154462 V1237299 PRE S plasmid recombination enzyme 0XTDI Cluster_223162 V1237302 AQPZ G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) COG0580 Cluster_439014 V1237305 S phospholipid-binding protein COG1881 Cluster_48321 V1237306 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_375313 V1237307 SSCG_01435 E ABC transporter COG0765 Cluster_79485 V1237308 ASPC map00250,map00290,map01100,map01110,map01210,map01230 E Aminotransferase COG0436 Cluster_74185 V1237310 M (sortase) family COG3764 Cluster_26150 V1237311 MRCB map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_302233 V1237312 RSME S Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) COG1385 Cluster_156961 V1237313 PHOH T Phoh family COG1702 Cluster_90914 V1237314 DINF V Mate efflux family protein COG0534 Cluster_315339 V1237315 MURI map00471,map01100 M Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) COG0796 Cluster_416172 V1237317 S ApbE family 11H27 Cluster_387740 V1237318 S Leucine rich repeat variant 11WCW Cluster_368651 V1237319 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_255221 V1237320 BIRA map00780,map01100 H biotin acetyl-CoA-carboxylase ligase COG0340 Cluster_310746 V1237322 PURC map00230,map01100,map01110 F SAICAR synthetase COG0152 Cluster_149591 V1237323 S NA 0Y5S2 Cluster_85543 V1237326 RND J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) COG0349 Cluster_18319 V1237327 S NA 0Y9Z0 Cluster_19995 V1237328 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_71828 V1237329 S Replication initiator protein 0XR3Z Cluster_315340 V1237330 S Phospholipase Carboxylesterase 11SWE Cluster_82546 V1237331 S NA 11U6K Cluster_36688 V1237332 YFMR S abc transporter COG0488 Cluster_24284 V1237333 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_80167 V1237335 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_15776 V1237336 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_439015 V1237339 S NA 0ZUV9 Cluster_60391 V1237341 M Inherit from NOG: Lpxtg-motif cell wall anchor domain protein 0Y6CS Cluster_8649 V1237342 U, W Pfam:YadA COG5295 Cluster_142776 V1237343 GLF M udp-galactopyranose mutase COG0562 Cluster_292668 V1237344 RV2219 S integral membrane protein 0Z3WW Cluster_785295 V1237345 SP_0256 K acetyltransferase, (GNAT) family COG0454 Cluster_130343 V1237347 P integral membrane protein COG1253 Cluster_40073 V1237348 MT0613 S integral membrane protein COG0392 Cluster_329103 V1237351 E Hydrolase COG0637 Cluster_300851 V1237352 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_35046 V1237353 V ABC transporter COG1132 Cluster_117000 V1237354 HOM map00260,map00270,map00300,map01100,map01110,map01120,map01230 E homoserine dehydrogenase COG0460 Cluster_15641 V1237355 S NA 101UU Cluster_637017 V1237356 GATC map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0721 Cluster_212705 V1237357 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_210482 V1237358 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate (By similarity) COG0167 Cluster_257740 V1237359 PYRK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) COG0543 Cluster_196976 V1237360 PYRF map00240,map00983,map01100 F orotidine 5''-phosphate decarboxylase COG0284 Cluster_699254 V1237362 S Toxin-antitoxin system, toxin component 0XRRU Cluster_61559 V1237363 SCLAV_1000 S TPR-repeat-containing protein 10GX4 Cluster_360443 V1237364 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_451027 V1237368 FHAB T Fha domain containing protein COG1716 Cluster_403598 V1237369 PCP O Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) COG2039 Cluster_284495 V1237370 NUCS L Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) COG1637 Cluster_11055 V1237371 S surface protein 11NE4 Cluster_275082 V1237374 map00750,map01100 C Aldo Keto reductase COG0667 Cluster_294040 V1237377 S NA 11SYG Cluster_156111 V1237378 S Phage Portal Protein COG4695 Cluster_344143 V1237379 map04112 O ATP-dependent Clp protease, proteolytic subunit COG0740 Cluster_355417 V1237380 BL03504 S phage major capsid protein, HK97 family 0XTEI Cluster_12457 V1237381 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_13829 V1237382 G Aamy_C COG1523 Cluster_159547 V1237383 map00250,map00290,map01100,map01110,map01210,map01230 E Aminotransferase COG0436 Cluster_315341 V1237384 PPGK map00010,map00520,map01100,map01110,map01120 G Polyphosphate glucokinase COG1940 Cluster_348962 V1237385 YTFP S hi0933 family COG2081 Cluster_336597 V1237386 K GntR Family Transcriptional Regulator COG2188 Cluster_284496 V1237387 RV1825 S Bacterial protein of unknown function (DUF881) COG3879 Cluster_755044 V1237388 SERB map00260,map00680,map01100,map01120,map01230 E phosphoserine phosphatase COG0560 Cluster_221987 V1237389 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_546033 V1237390 S kila-n, DNA-binding domain 0XPNQ Cluster_344144 V1237391 I diacylglycerol kinase, catalytic COG1597 Cluster_64023 V1237392 RV3193C S UPF0182 protein COG1615 Cluster_64844 V1237393 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_27184 V1237395 TRAA L TrwC relaxase COG0507 Cluster_339572 V1237396 MNTA map02010,map02020 P (ABC) transporter COG1121 Cluster_465168 V1237397 map02010 V ABC transporter COG1132 Cluster_64845 V1237402 DPPA map02010 E ABC transporter substrate-binding protein COG4166 Cluster_182093 V1237403 TAL map00010,map00030,map00500,map00520,map00710,map01051,map01100,map01110,map01120,map01230 G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) COG0176 Cluster_724950 V1237404 S Abortive infection protein AbiGII 0XQHH Cluster_400042 V1237405 S NA 0YXW2 Cluster_341034 V1237406 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_85919 V1237407 GLDE P CBS domain containing protein COG1253 Cluster_189895 V1237408 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_312265 V1237409 D YhjQ protein COG1192 Cluster_95707 V1237411 L Domain protein COG0507 Cluster_31846 V1237412 M Cell wall anchor domain protein 11Q8J Cluster_233709 V1237416 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_382364 V1237417 PDXT map00750 H Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) COG0311 Cluster_237303 V1237418 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_126805 V1237419 DINB L Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) COG0389 Cluster_86384 V1237420 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_89516 V1237421 SCLAV_4061 S Uncharacterised conserved protein (DUF2342) COG5282 Cluster_199901 V1237423 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_169470 V1237424 S NA 11QED Cluster_610571 V1237425 FOLA map00670,map00790,map01100 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) COG0262 Cluster_441001 V1237426 WZB T protein tyrosine phosphatase COG0394 Cluster_347352 V1237429 SIGH K rna polymerase sigma factor COG1595 Cluster_287354 V1237431 map00510,map01100 M Glycosyl transferase family 2 COG0463 Cluster_410713 V1237432 ATPH map00190,map00195,map01100 C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) COG0712 Cluster_166159 V1237433 LYTR2 K TRANSCRIPTIONal COG1316 Cluster_206141 V1237434 D ftsk spoIIIe COG1674 Cluster_97887 V1237435 S DivIVA domain repeat protein 11XZ2 Cluster_131898 V1237436 SUFD O feS assembly protein SufD COG0719 Cluster_408857 V1237437 RIMM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) COG0806 Cluster_315342 V1237438 SCLAV_5050 map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_27888 V1237439 S NA 11QZ9 Cluster_67151 V1237442 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_164496 V1237443 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_444994 V1237444 UVRD2 map03420,map03430 L helicase COG2887 Cluster_31969 V1237445 YDGH S MMPL domain protein COG2409 Cluster_96816 V1237446 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_107640 V1237447 RV2242 K Transcriptional regulator COG2508 Cluster_329104 V1237449 S integral membrane protein COG5523 Cluster_279076 V1237452 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_225515 V1237453 V FtsX-like permease family COG0577 Cluster_68901 V1237454 S domain protein 0YF83 Cluster_377079 V1237455 S NA 11RJG Cluster_800989 V1237456 S NA 0XVT8 Cluster_179506 V1237457 map02010 V ABC transporter COG1132 Cluster_260369 V1237459 S S-layer domain protein 11R54 Cluster_187327 V1237460 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_32852 V1237461 S NA 0YG6V Cluster_487322 V1237463 map03440 K Inherit from COG: Transcriptional regulator COG2865 Cluster_83398 V1237464 S S-layer domain protein 11R54 Cluster_497162 V1237465 S NA 0ZHU9 Cluster_124757 V1237467 V FtsX-like permease family COG0577 Cluster_467253 V1237468 LUXS map00270,map05111 T Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) COG1854 Cluster_423409 V1237469 CYSE S -acetyltransferase 11PF0 Cluster_377080 V1237470 GLUQ map00860,map00970,map01100,map01110 J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) COG0008 Cluster_90915 V1237471 AROB map00400,map01100,map01110,map01230 E 3-dehydroquinate synthase COG0703 Cluster_127498 V1237472 S PAP2 superfamily 0XZ0P Cluster_708514 V1237473 INO1 map00521,map00562,map01100,map01110 I synthase COG1260 Cluster_206142 V1237474 PSTA map02010 P phosphate ABC transporter, permease COG0581 Cluster_310747 V1237475 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_116297 V1237477 S NA 0YDZN Cluster_221988 V1237479 CKL_1893 S Phage replisome organizer 11V35 Cluster_517894 V1237480 K Transcriptional regulator 0Y1S3 Cluster_91384 V1237481 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_176142 V1237482 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_191669 V1237483 J Translation initiation factor IF-2, N-terminal region COG0532 Cluster_62634 V1237484 GYRA2 L DNA topoisomerase IV subunit A COG0188 Cluster_239893 V1237486 OCAR_6158 L Terminase, large subunit COG4626 Cluster_421547 V1237488 HSDS2 V Type I restriction modification DNA specificity domain COG0732 Cluster_54032 V1237490 ASNB map00250,map00910,map01100,map01110,map01120 E Asparagine synthetase COG0367 Cluster_170336 V1237491 PROB map00330,map01100,map01230 E Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) COG0263 Cluster_389437 V1237492 MUTF map02010 V ABC transporter, ATP-binding protein COG1131 Cluster_207241 V1237493 QOR map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120 C alcohol dehydrogenase COG0604 Cluster_637019 V1237494 YDEP K Transcriptional regulator COG1733 Cluster_570066 V1237495 L Addiction module antitoxin, RelB DinJ family COG3077 Cluster_425207 V1237496 YDIB S ATP-binding protein COG0802 Cluster_336598 V1237500 BL03504 S phage major capsid protein, HK97 family 0XTEI Cluster_238618 V1237501 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_104606 V1237502 GLMU map00520,map01100,map01110 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) COG1207 Cluster_42017 V1237504 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_96298 V1237505 GATB map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 Cluster_333564 V1237506 NT5E map00230,map00240,map00630,map00760,map01100,map01110 S Hydrolase COG0546 Cluster_193491 V1237507 map00561,map01100 M group 1 glycosyl transferase COG0438 Cluster_65697 V1237509 M Inherit from NOG: Lpxtg-motif cell wall anchor domain protein 0Y6CS Cluster_72826 V1237510 SCLAV_4061 S Uncharacterised conserved protein (DUF2342) COG5282 Cluster_345762 V1237512 YACL S PilT protein domain protein COG4956 Cluster_119896 V1237513 FTSE map02010 D Cell division ATP-binding protein ftsE COG2884 Cluster_224346 V1237514 LDH map00010,map00270,map00620,map00640,map01100,map01110,map01120 C L-lactate dehydrogenase COG0039 Cluster_45172 V1237515 U, W Pfam:YadA COG5295 Cluster_195308 V1237517 FRDB map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020 C succinate dehydrogenase COG0479 Cluster_137483 V1237518 map04112 M Cell division protein FtsQ COG1589 Cluster_299476 V1237519 PROC map00330,map01100,map01110,map01230 E pyrroline-5-carboxylate reductase COG0345 Cluster_475797 V1237521 PHEA map00400,map01100,map01110,map01230 E Prephenate dehydratase COG0077 Cluster_142777 V1237522 GLNE O, T Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) COG1391 Cluster_107058 V1237523 COMEC S ComEC Rec2-like protein COG0658 Cluster_300852 V1237526 PABC map00280,map00290,map00310,map00330,map00360,map00472,map00473,map00770,map00790,map01100,map01110,map01210,map01230 E brancheD-chain amino acid aminotransferase COG0115 Cluster_473641 V1237530 RECG map03440 L ATP-dependent DNA helicase RecG COG1200 Cluster_141272 V1237531 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_269755 V1237534 THRB map00260,map01100,map01120,map01230 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) COG0083 Cluster_54537 V1237535 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_62378 V1237538 P binding-protein-dependent transport systems inner membrane Component COG4986 Cluster_91869 V1237539 THRC map00260,map00750,map01100,map01120,map01230 E Threonine synthase COG0498 Cluster_84287 V1237541 HLY map04621 S Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation 0XQPX Cluster_699255 V1237545 S Inherit from COG: ATPase (AAA COG1373 Cluster_217342 V1237546 MUTY map03410 L a g-specific adenine glycosylase COG1194 Cluster_321413 V1237548 LOLD V abc transporter atp-binding protein COG1136 Cluster_582852 V1237550 SP_0276 S addiction module toxin, RelE StbE family COG3041 Cluster_60963 V1237551 U, W Pfam:YadA COG5295 Cluster_365325 V1237553 RPE map00030,map00040,map00710,map01100,map01110,map01120,map01230 G ribulose-phosphate 3-epimerase COG0036 Cluster_65105 V1237554 S NA 103RQ Cluster_520455 V1237555 GLUD map02010 E amino acid AbC transporter COG0765 Cluster_62902 V1237556 T Histidine kinase COG4585 Cluster_63466 V1237561 G Aamy_C COG1523 Cluster_259064 V1237564 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_73859 V1237567 LMRB P drug resistance transporter, EmrB QacA subfamily 0XNN3 Cluster_169471 V1237569 SCLAV_1560 map02010 P ABC transporter COG1122 Cluster_100018 V1237570 HRPA L ATP-dependent helicase COG1643 Cluster_132653 V1237574 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_350584 V1237575 PYRE map00240,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_95208 V1237576 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_67893 V1237577 U, W Inherit from COG: domain protein COG5295 Cluster_68902 V1237578 S Type II DNA modification methyltransferase 0ZM02 Cluster_653048 V1237579 SCLAV_4786 S NA 11QMH Cluster_87268 V1237583 THIM map00730,map01100 H 4-methyl-5-beta-hydroxyethylthiazole kinase COG2145 Cluster_70543 V1237584 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_702327 V1237585 MIAB J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) COG0621 Cluster_156962 V1237587 P Heavy-metal-associated domain COG2217 Cluster_73519 V1237589 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_74818 V1237590 U, W Pfam:YadA COG5295 Cluster_136692 V1237592 AROA map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate synthase COG0128 Cluster_820804 V1237593 L NA 121AE Cluster_543083 V1237598 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_683263 V1237599 BMUL_4952 K addiction module antidote protein COG3636 Cluster_205058 V1237600 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_231282 V1237602 THID map00730,map01100 H phosphomethylpyrimidine kinase COG0351 Cluster_132654 V1237604 PURB map00230,map00250,map00362,map01100,map01110,map01120 F adenylosuccinate lyase COG0015 Cluster_648969 V1237605 map00051 M glycosyltransferase group 2 family protein COG0463 Cluster_161219 V1237606 ELI_1299 S Phage major capsid protein COG4653 Cluster_267004 V1237607 S CAAX amino terminal protease family 0XUJM Cluster_90430 V1237608 RECG map03440 L ATP-dependent DNA helicase RecG COG1200 Cluster_84715 V1237609 MT3296 L helicase COG0210 Cluster_573273 V1237610 S NA 12BYG Cluster_144223 V1237611 LYSP E permease COG0833 Cluster_748169 V1237613 SSCG_03340 S Membrane COG2860 Cluster_425208 V1237615 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_540192 V1237616 U Protein of unknown function (DUF805) 0XVF5 Cluster_89062 V1237617 MT3296 L helicase COG0210 Cluster_140520 V1237619 PYRB map00240,map00250,map01100 F aspartate transcarbamylase COG0540 Cluster_307882 V1237623 GLPF G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) COG0580 Cluster_149592 V1237625 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_158697 V1237626 THETH_0161 L Transposase COG3328 Cluster_93302 V1237628 CTPE P ATPase, P-type (Transporting), HAD superfamily, subfamily IC COG0474 Cluster_160389 V1237629 FLIC map02020,map02040,map04626,map05132,map05134 N Flagellin COG1344 Cluster_560819 V1237630 DEF J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) COG0242 Cluster_551960 V1237632 RV2326C map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_557764 V1237633 map03060,map03070 U Preprotein translocase subunit COG1862 Cluster_98441 V1237634 S TPR repeat-containing protein COG0457 Cluster_108800 V1237635 FLIC map02020,map02040,map04626,map05132,map05134 N Flagellin COG1344 Cluster_324558 V1237636 PDXH S Pyridoxamine 5'-phosphate oxidase 11K9A Cluster_249068 V1237638 HSLO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) COG1281 Cluster_307883 V1237639 LEXA K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) COG1974 Cluster_309295 V1237641 SCLAV_2398 T response regulator COG2197 Cluster_417977 V1237643 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_350585 V1237644 S CHAP domain COG3942 Cluster_407084 V1237645 MVK map00900,map01100,map01110,map04146 I mevalonate kinase COG1577 Cluster_298194 V1237647 S Fic/DOC family 0ZXM7 Cluster_185570 V1237649 PSAA map02010 P ABC transporter COG0803 Cluster_195309 V1237651 YDBI S Membrane COG0628 Cluster_592716 V1237653 TIG O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COG0544 Cluster_526134 V1237656 YLBN S metal-binding protein COG1399 Cluster_255222 V1237657 LGT M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 Cluster_371980 V1237658 S ErfK ybiS ycfS ynhG family protein COG1376 Cluster_247750 V1237659 PRFA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) COG0216 Cluster_715040 V1237660 TXE S Addiction module toxin, Txe YoeB family COG4115 Cluster_614229 V1237661 L Addiction module antitoxin, RelB DinJ family 122EC Cluster_119132 V1237662 YIEG S Xanthine uracil vitamin C permease COG2252 Cluster_276413 V1237667 METF map00670,map00720,map01100,map01120 E Methylenetetrahydrofolate reductase COG0685 Cluster_123465 V1237669 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_283125 V1237672 EXOA map03410 L Exodeoxyribonuclease III COG0708 Cluster_319934 V1237676 RPH map00230,map00240,map01100 J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) COG0689 Cluster_528893 V1237677 YFMR S abc transporter COG0488 Cluster_573274 V1237678 SP_1634 S Protein of unknown function (DUF2974) 0XSVF Cluster_260370 V1237679 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_499828 V1237680 PHOU P Plays a role in the regulation of phosphate uptake COG0704 Cluster_296798 V1237684 UDP map00230 S phosphorylase 11F11 Cluster_287355 V1237688 METN map02010 P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COG1135 Cluster_394808 V1237689 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_338151 V1237694 PYRB map00240,map00250,map01100 F aspartate transcarbamylase COG0540 Cluster_138244 V1237695 FAS map00061,map00350,map00362,map00627,map00642,map00903,map01100,map01120 I synthase COG4982 Cluster_380590 V1237698 RPLC map03010 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 Cluster_139785 V1237699 CTPA M Carboxyl-terminal protease COG0793 Cluster_360444 V1237700 ENC_10390 S Membrane COG3819 Cluster_140521 V1237701 S NA 0YBPX Cluster_871915 V1237702 TRML map04122 J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) COG0219 Cluster_330503 V1237709 MT1053 D Septum formation initiator family protein COG1507 Cluster_171156 V1237713 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_275083 V1237714 YVGN C reductase COG0656 Cluster_380591 V1237715 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_182994 V1237716 RHLE map03018 L Helicase COG0513 Cluster_425209 V1237718 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_157829 V1237723 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_661390 V1237724 4HBD map00650 C NAD-dependent 4-hydroxybutyrate dehydrogenase COG1454 Cluster_272395 V1237725 map00750,map01100 C Aldo Keto reductase COG0667 Cluster_665591 V1237726 S nifU domain-containing protein 12280 Cluster_289995 V1237727 SSUC map02010 P Binding-protein-dependent transport systems, inner membrane component COG0600 Cluster_537391 V1237729 map02010 P ABC transporter substrate-binding protein COG0715 Cluster_711656 V1237730 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_469381 V1237735 S Inherit from COG: Phage-Associated Protein COG3600 Cluster_166886 V1237737 PYRC map00230,map00240,map01100,map01120 F dihydroorotase COG0044 Cluster_433006 V1237739 L Integrase core domain protein COG2801 Cluster_251541 V1237740 E, G Membrane COG0697 Cluster_199902 V1237743 PROA map00330,map01100,map01230 E Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) COG0014 Cluster_169472 V1237745 MT3296 L helicase COG0210 Cluster_170337 V1237746 LMRB P drug resistance transporter, EmrB QacA subfamily 0XNN3 Cluster_171157 V1237747 S NA 0XZ3T Cluster_380592 V1237749 S RelA SpoT domain protein 11ZK7 Cluster_175344 V1237751 S NA 11VT6 Cluster_172890 V1237752 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_197906 V1237755 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_175345 V1237756 TILS map00230,map00983,map01100,map01110 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) COG0037 Cluster_176144 V1237757 map02010 P ABC transporter COG1122 Cluster_234906 V1237759 MNTA map02010 P periplasmic solute binding protein COG0803 Cluster_403599 V1237760 PCCB map00280,map00630,map00640,map00720,map01100,map01120 I carboxyl transferase COG4799 Cluster_246493 V1237762 OPPA E ABC transporter COG0747 Cluster_216148 V1237770 PDXP G hydrolase COG0647 Cluster_603274 V1237773 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_711657 V1237774 K transcriptional regulator with C-terminal CBS domains 0XUC3 Cluster_236107 V1237777 CPSY K Transcriptional regulator COG0583 Cluster_669871 V1237781 S NA 0ZHU9 Cluster_296799 V1237783 map00051 G class II Aldolase COG0235 Cluster_197907 V1237784 FAS map00061,map00350,map00362,map00627,map00642,map00903,map01100,map01120 I synthase COG4982 Cluster_766301 V1237788 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_617982 V1237789 RPSM map03010 J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits COG0099 Cluster_251542 V1237792 S Hydrolase COG4814 Cluster_279078 V1237793 map02010 V Abc transporter COG1132 Cluster_209408 V1237794 P Transporter COG0733 Cluster_210483 V1237796 K Transcriptional regulator COG1609 Cluster_252757 V1237799 HRPA L ATP-dependent helicase COG1643 Cluster_652009 V1023601 YIBI S Protein of unknown function (DUF3302) 17F8Y@proNOG Cluster_291050 V1023605 FABG map00061,map00780,map01040,map01100 I reductase COG1028 Cluster_315022 V1023606 RLX U relaxase mobilization nuclease domain protein COG3843 Cluster_292375 V1023608 G Inherit from NOG: Cellulase (glycosyl hydrolase family 5) 0ZVSV Cluster_533765 V1023609 S similarity to GP 11230710 0YRAJ Cluster_291051 V1023610 YVBT C Luciferase family COG2141 Cluster_292376 V1023611 map00051,map00500,map00520,map01100 G pfkb domain protein COG0524 Cluster_406713 V1023612 Y2213 S NA 177TM@proNOG Cluster_847167 V1023613 Y2212 S phage protein COG5556 Cluster_545249 V1023614 VIRE2 S Virulence-associated protein e COG5545 Cluster_528243 V1023615 S Structural protein 17FQ5@proNOG Cluster_292377 V1023617 L Inherit from COG: Helicase COG1112 Cluster_408461 V1023619 S NA 0YHQV Cluster_292378 V1023620 map03022,map03420 L type iii restriction protein res subunit COG1061 Cluster_477459 V1023622 MCSA S Uvrb UvrC protein COG3880 Cluster_292379 V1023624 CCH L SCCmec staphylococcal cassette region, isolate CMFT106 COG5519 Cluster_530992 V1023625 YWFO S Phosphohydrolase COG1078 Cluster_293750 V1023627 GULO map00053,map01100 C oxidoreductase COG0277 Cluster_368325 V1023630 GLGB map00500,map01100,map01110 G 1,4-alpha-glucan branching enzyme COG0296 Cluster_293751 V1023631 V type I restriction modification DNA specificity domain protein COG0732 Cluster_311982 V1023632 SCAD N, U domain protein COG3942 Cluster_542263 V1023636 CCH L SCCmec staphylococcal cassette region, isolate CMFT106 COG5519 Cluster_355037 V1023639 OMPL M Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is 16ZVK@proNOG Cluster_369977 V1023645 S Inherit from COG: Pfam:DUF567 COG4894 Cluster_295163 V1023646 L Transposase COG3039 Cluster_484471 V1023648 NTPF S H -ATPase, subunit H 122TR Cluster_295164 V1023653 YBEY map00240,map00983,map01100 F Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) COG0319 Cluster_295165 V1023654 DCTP C symporter COG1301 Cluster_373256 V1023655 TRPH S PHP domain protein COG0613 Cluster_295166 V1023657 map00310,map00780,map01100 E Peptidase, S9A B C family, catalytic domain protein COG1506 Cluster_419290 V1023659 PGL map00030,map01100,map01110,map01120 G 6-phosphogluconolactonase (EC 3.1.1.31) COG0363 Cluster_765308 V1023660 GLK map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G glucokinase (EC 2.7.1.2) COG0837 Cluster_628200 V1023662 ALKA map03410 L 8-oxoguanine DNA glycosylase COG0122 Cluster_835281 V1023664 S NA 0ZHU9 Cluster_296563 V1023665 S NA 11JP6 Cluster_423008 V1023666 RLUB J Pseudouridine synthase COG1187 Cluster_296565 V1023668 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_494057 V1023669 ISPF map00900,map01100,map01110 I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) COG0245 Cluster_296566 V1023671 CBPA M Choline binding protein A 11T5H Cluster_297932 V1023672 S NA 0XW3Z Cluster_297933 V1023673 DPRA L DNA protecting protein DprA COG0758 Cluster_517249 V1023677 S Membrane COG2860 Cluster_682178 V1023678 map00230 K, T Metal Dependent Phosphohydrolase COG0317 Cluster_360091 V1023679 ARGF map00330,map01100,map01110,map01230 E ornithine carbamoyltransferase COG0078 Cluster_624501 V1023680 E Glyoxalase Bleomycin resistance protein (Dioxygenase COG0346 Cluster_528244 V1023681 RPIB map00030,map00710,map01100,map01110,map01120,map01230 G isomerase B COG0698 Cluster_380179 V1023682 S NA 11W9N Cluster_383746 V1023684 SCLAV_0509 S Cytochrome c oxidase caa3-type, assembly factor ctag-related protein COG3336 Cluster_299220 V1023685 AMIA M n-acetylmuramoyl-l-alanine amidase COG0860 Cluster_428592 V1023691 J sua5 ycio yrdc ywlc family protein COG0009 Cluster_578770 V1023693 K Transcriptional regulator COG0789 Cluster_664534 V1023694 MODB map02010 P molybdate abc transporter COG4149 Cluster_456486 V1023696 OADA map00020,map00330,map00620,map00720,map01100,map01120,map01230 C Oxaloacetate decarboxylase COG5016 Cluster_444561 V1023697 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_796118 V1023699 IRP6A map02010 P Periplasmic binding protein COG0614 Cluster_397955 V1023700 BMUL_5788 S Plasmid replication region DNA-binding N-term 17D0B@proNOG Cluster_525420 V1023701 MMDC map00061,map00253,map00620,map00640,map00720,map01100,map01110,map01120 I biotin lipoyl attachment domaiN-containing protein COG4770 Cluster_299222 V1023705 S NA 11EMI Cluster_620755 V1023706 S NA 1297W Cluster_525421 V1023707 S Capsular polysaccharide biosynthesis protein 0XUBN Cluster_792171 V1023708 S Protein of unknown function (DUF3164) 11TRN Cluster_464694 V1023709 S NA 11KFV Cluster_499204 V1023710 S NA 0YIEB Cluster_466710 V1023713 S Protein of unknown function (DUF935) COG4383 Cluster_545250 V1023714 map02010 E Binding-protein-dependent transport system inner membrane component COG1174 Cluster_598857 V1023715 OPUCC map02010 M Glycine betaine COG1732 Cluster_652011 V1023716 S -acetyltransferase COG2388 Cluster_468894 V1023718 S dNA-binding protein 0Y077 Cluster_299224 V1023719 U, W Inherit from COG: domain protein COG5295 Cluster_300554 V1023720 S fibronectin type III domain protein 11FT5 Cluster_363233 V1023723 LYSR K LysR family (Transcriptional regulator COG0583 Cluster_466711 V1023724 YHCC S Radical SAM Protein COG1242 Cluster_613274 V1023725 S NA 12490 Cluster_300555 V1023726 ARSB P arsenical pump membrane protein COG1055 Cluster_300556 V1023727 map01053 Q non-ribosomal peptide synthetase COG1020 Cluster_776547 V1023731 S helix-turn-helix domain protein 122WR Cluster_581983 V1023741 YUGI J RNA binding s1 domain protein COG1098 Cluster_303372 V1023742 MBTB map01053 Q non-ribosomal peptide synthetase COG1020 Cluster_415806 V1023744 YBET S Inherit from bactNOG: Sel1 domain protein repeat-containing protein COG0790 Cluster_303373 V1023747 M domain protein COG4932 Cluster_331785 V1023748 K, L Inherit from COG: helicase COG0553 Cluster_408462 V1023752 S NA 0YSDZ Cluster_482159 V1023753 DEF J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) COG0242 Cluster_698525 V1023754 S NA 11QY9 Cluster_364941 V1023756 S NA 17MR8@proNOG Cluster_808232 V1023758 DPNII V Type II restriction 0YTH4 Cluster_307656 V1023759 V DNA specificity domain protein COG0732 Cluster_404973 V1023760 N Cell surface protein 1CAVF@tenNOG Cluster_404974 V1023761 PHOU P Plays a role in the regulation of phosphate uptake COG0704 Cluster_408463 V1023764 YJIJ G Major Facilitator 16PQU@proNOG Cluster_351766 V1023765 PONA map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_772733 V1023767 S sialic acid-specific 9-O-acetylesterase 0XQ2Q Cluster_304890 V1023768 PULQ map03070 U Type II and III secretion system protein COG4796 Cluster_496551 V1023770 NDK map00230,map00240,map01100,map01110 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) COG0105 Cluster_780110 V1023771 CMK map00240,map00410,map00770,map01100,map01110 F Cytidine monophosphate kinase COG0283 Cluster_413994 V1023774 SSB2 map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_462592 V1023775 YHCY T Histidine kinase COG4585 Cluster_424787 V1023778 PANB map00770,map01100,map01110 H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) COG0413 Cluster_850854 V1023779 DGK map00230,map01100 F deoxynucleoside kinase COG1428 Cluster_336285 V1023780 map00500,map00511,map01100 N Alpha-L-fucosidase 0XPGV Cluster_475252 V1023781 S NA 0ZWKI Cluster_542265 V1023783 S Nucleotidyltransferase domain 0ZNBK Cluster_304891 V1023784 E Dipeptidase COG4690 Cluster_473127 V1023785 CYAA map00230,map04113 S Adenylate cyclase COG2954 Cluster_585222 V1023787 YJGF J endoribonuclease L-psp COG0251 Cluster_306293 V1023793 L Pfam:Transposase_7 COG4644 Cluster_306294 V1023794 M n-acetylmuramoyl-l-alanine amidase 123FY Cluster_438554 V1023795 RPSP map03010 J 30s ribosomal protein S16 COG0228 Cluster_306295 V1023796 S metallophosphoesterase 0XQXV Cluster_717506 V1023798 L Addiction module antitoxin, RelB DinJ family COG3077 Cluster_333246 V1023799 HISC map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01230 E imidazole acetol-phosphate transaminase COG0079 Cluster_212706 V1237801 V Mate efflux family protein COG0534 Cluster_549076 V1237802 ECFT map02010 P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) COG0619 Cluster_262981 V1237804 CADA P heavy metal translocating p-type ATPase COG2217 Cluster_315344 V1237805 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_217343 V1237807 S Inherit from NOG: domain protein 0XXVB Cluster_401825 V1237809 V abc transporter COG1132 Cluster_330504 V1237810 NNRD G carbohydrate kinase, YjeF related protein COG0063 Cluster_534496 V1237811 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_220821 V1237812 U, W Pfam:YadA COG5295 Cluster_341035 V1237814 ADHE map00010,map00051,map00071,map00350,map00362,map00363,map00591,map00620,map00621,map00622,map00625,map00626,map00650,map01100,map01110,map01120 C alcohol dehydrogenase COG1454 Cluster_355418 V1237815 PYRE map00240,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_230104 V1237822 S NA 101UU Cluster_232445 V1237825 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_425210 V1237827 MENA map00130,map01100,map01110 H 1,4-dihydroxy-2-naphthoate octaprenyltransferase COG1575 Cluster_241167 V1237828 S Inherit from NOG: LPXTG-motif cell wall anchor domain protein 0YEBJ Cluster_243894 V1237834 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_603275 V1237835 OPPB P ABC transporter (Permease COG0601 Cluster_475798 V1237836 ACPS map00770 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) COG0736 Cluster_384132 V1237838 YDCQ D ftsk SpoIIIE family protein COG1674 Cluster_326054 V1237840 S 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein COG5617 Cluster_497163 V1237842 TYRA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydrogenase COG0287 Cluster_252758 V1237845 S NA 0ZTYV Cluster_255223 V1237848 RV2326C map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_256451 V1237850 S NA 0ZTYV Cluster_648971 V1237851 PARB K parb-like partition protein COG1475 Cluster_728238 V1237852 S NA 0ZHU9 Cluster_257741 V1237853 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_259065 V1237856 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit alpha COG0587 Cluster_551961 V1237858 S NA 0ZHU9 Cluster_261684 V1237859 S NA 101UU Cluster_358775 V1237861 PEPP E Xaa-Pro aminopeptidase COG0006 Cluster_344145 V1237865 SCLAV_4792 G Major Facilitator superfamily 0XQD0 Cluster_268417 V1237867 GYRA2 L DNA topoisomerase IV subunit A COG0188 Cluster_708516 V1237868 S virulence-like protein 0ZW8F Cluster_267005 V1237869 CAS1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) COG1518 Cluster_268418 V1237871 DPPD map02010 S ABC transporter COG1123 Cluster_515221 V1237872 ISCU C SUF system FeS assembly protein COG0822 Cluster_715041 V1237880 CTPE P ATPase, P-type (Transporting), HAD superfamily, subfamily IC COG0474 Cluster_371981 V1237881 S NA 0ZHU9 Cluster_728239 V1237882 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_276414 V1237883 S NA 0Y9Z0 Cluster_449059 V1237884 T Positive regulator of sigma E, RseC MucC 123KF Cluster_347353 V1237885 GLPF G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) COG0580 Cluster_277719 V1237887 NRDF map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_339573 V1237888 TAUB P ABC transporter COG1116 Cluster_728240 V1237889 SUN_0728 L transposase (IS4 family) protein 12CNV Cluster_469382 V1237891 MUTS2 map03430 L muts2 protein COG1193 Cluster_669872 V1237894 S Conserved hypothetical protein 698 COG2855 Cluster_305190 V1237898 YLMH J s4 domain protein COG2302 Cluster_599704 V1237900 S kila-n, DNA-binding domain 0XPNQ Cluster_287356 V1237901 S NA 129FA Cluster_324559 V1237903 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_748171 V1237905 MURI map00471,map01100 M Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) COG0796 Cluster_291307 V1237907 S NA 0YZ82 Cluster_629134 V1237909 RBSK map00030 G ribokinase COG0524 Cluster_773711 V1237911 S NA 0ZHU9 Cluster_777437 V1237923 YEAO S MarR family Transcriptional regulator COG3189 Cluster_385908 V1237926 P Chloride channel COG0038 Cluster_368652 V1237927 PSTB1 map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_614231 V1237932 KDSA map00540,map01100 M Phospho-2-dehydro-3-deoxyoctonate aldolase COG2877 Cluster_614232 V1237934 S NA 0ZHU9 Cluster_329105 V1237935 NHAA map00680 P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) COG3004 Cluster_755048 V1237939 S NA 0ZHU9 Cluster_303686 V1237944 PEPD E Dipeptidase COG4690 Cluster_551962 V1237945 MECA O Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis COG4862 Cluster_570067 V1237946 K HTH_ARAC COG2207 Cluster_762347 V1237947 RPMI map03010 J 50S ribosomal protein L35 COG0291 Cluster_408858 V1237948 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_419755 V1237950 map00561,map01100 M group 1 glycosyl transferase COG0438 Cluster_427129 V1237953 UGPA map00040,map00052,map00500,map00520,map01100,map01110 G UTP-glucose-1-phosphate uridylyltransferase COG4284 Cluster_480393 V1237954 DEOB map00030,map00230 G Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) COG1015 Cluster_309296 V1237956 S NA 0ZYTH Cluster_377081 V1237964 SLT M lytic transglycosylase COG0741 Cluster_925526 V1237965 V Type III COG3587 Cluster_380593 V1237966 L DNA Methylase COG2189 Cluster_744814 V1237969 TYRA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydrogenase COG0287 Cluster_352081 V1237970 GATB map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 Cluster_509949 V1237973 ULAC map00051,map00053,map01100,map01120,map02060 G IIa component COG1762 Cluster_335070 V1237974 V Type III COG3587 Cluster_421548 V1237976 GLNQ map02010 E abc transporter atp-binding protein COG1126 Cluster_326055 V1237982 SACY K antiterminator COG3711 Cluster_326056 V1237983 NRDE map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_785297 V1237984 S kila-n, DNA-binding domain 0XPNQ Cluster_549078 V1237985 S NA 0ZHU9 Cluster_329106 V1237989 S von Willebrand factor type 11R5D Cluster_744815 V1237996 S Vanz family COG5652 Cluster_333565 V1237997 map02010 P ABC transporter COG1122 Cluster_504770 V1238000 S NA 0XZTD Cluster_683265 V1238001 S NA 0ZHU9 Cluster_335071 V1238003 map02010 P ABC transporter substrate-binding protein COG0715 Cluster_467254 V1238004 S NA 0YU7N Cluster_589354 V1238006 S mobilization protein 11RWB Cluster_665593 V1238008 S NA 0YWXK Cluster_338152 V1238009 HRM2_08390 L transposase (IS4 family) protein 0XQ88 Cluster_473643 V1238011 C Flavodoxin COG0716 Cluster_339574 V1238012 GLCD map00620,map00630,map01100,map01110,map01120 C FAD linked oxidase domain protein COG0277 Cluster_341036 V1238015 L integrase family 0ZJHZ Cluster_551963 V1238017 S surface protein 11NE4 Cluster_888133 V1238018 SMPB O Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) COG0691 Cluster_345763 V1238019 MALZ map00052,map00500,map01100 G Alpha-glucosidase COG1501 Cluster_678718 V1238020 GATC map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0721 Cluster_348963 V1238023 SCLAV_2116 M glycosyl transferase family 0XPWZ Cluster_460967 V1238024 DIVIVA D Cell division protein DIVIVA COG3599 Cluster_352082 V1238025 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_352083 V1238027 SUN J ribosomal RNA small subunit methyltransferase b COG0144 Cluster_844147 V1238030 S helix-turn-helix domain protein 122WR Cluster_360445 V1238031 HSDM V type I restriction-modification system COG0286 Cluster_362017 V1238037 MALL map00052,map00500,map01100 G trehalose-6-phosphate hydrolase (EC 3.2.1.93) COG0366 Cluster_385909 V1238042 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_363584 V1238043 UVRD2 map03420,map03430 L helicase COG2887 Cluster_363585 V1238044 FTSK D cell division protein FtsK COG1674 Cluster_365327 V1238050 FTSX map02010 D Part of the ABC transporter FtsEX involved in cellular division (By similarity) COG2177 Cluster_365328 V1238051 PHOR T Histidine kinase 0XNMH Cluster_363586 V1238052 OPPA E ABC transporter COG0747 Cluster_365329 V1238053 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_365330 V1238055 LYSX map00970,map05150 J Membrane COG2898 Cluster_368653 V1238059 V Mate efflux family protein COG0534 Cluster_427130 V1238063 K, L domain protein COG0553 Cluster_441002 V1238067 RPLE map03010 J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COG0094 Cluster_441003 V1238071 M Sortase family COG3764 Cluster_699256 V1238074 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_371982 V1238077 AMS1 map00511 G hydrolase, family 38 COG0383 Cluster_407085 V1238084 TDK map00240,map00983,map01100 F thymidine kinase COG1435 Cluster_375314 V1238085 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_375315 V1238086 GLYQS map00970 J Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) COG0423 Cluster_377082 V1238088 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_809221 V1238094 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_378863 V1238095 S kila-n, DNA-binding domain 0XPNQ Cluster_596193 V1238099 ALLB map00230,map00240,map01100,map01120 F Allantoinase (EC 3.5.2.5) COG0044 Cluster_380594 V1238100 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_384133 V1238102 PTH J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) COG0193 Cluster_741520 V1238109 SLGD_00064 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_644897 V1238115 PDXS map00750 H Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) COG0214 Cluster_389439 V1238121 INO1 map00521,map00562,map01100,map01110 I synthase COG1260 Cluster_389440 V1238123 CARA map00240,map00250,map01100 F carbamoyl-phosphate synthetase glutamine chain COG0505 Cluster_394809 V1238125 map02020,map02030 S Methyl-accepting chemotaxis protein (MCP) signalling domain COG0840 Cluster_509950 V1238126 S Esterase COG0627 Cluster_785299 V1238129 S NA 0ZHU9 Cluster_766302 V1238130 S NA 0ZHU9 Cluster_414402 V1238131 PRIA map03440 L Primosomal protein n' COG1198 Cluster_447037 V1238133 ARLS T Histidine kinase COG0642 Cluster_398305 V1238134 RPLD map03010 J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) COG0088 Cluster_408859 V1238135 DXS map00730,map00900,map01100,map01110 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) COG1154 Cluster_403600 V1238146 S Inherit from NOG: Tail protein 11MY0 Cluster_403601 V1238148 RECR map03440 L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) COG0353 Cluster_515223 V1238151 RPLI map03010 J Binds to the 23S rRNA (By similarity) COG0359 Cluster_405416 V1238152 S Uncharacterised ACR, YkgG family COG1556 0ZXQV Cluster_444996 V1238153 BIRA map00780,map01100 H biotin acetyl-CoA-carboxylase ligase COG0340 Cluster_449060 V1238155 SPEH map00270,map00330,map01100 S s-adenosylmethionine decarboxylase 12CCU Cluster_485036 V1238156 ULAA map00053,map01100,map01120,map02060 G PTS system ascorbate-specific transporter subunit IIC COG3037 Cluster_408860 V1238157 RECG map03440 L ATP-dependent DNA helicase RecG COG1200 Cluster_410714 V1238159 RNHA map03030 S ribonuclease COG3341 Cluster_523224 V1238170 RFBA map00521,map00523,map01100,map01110 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) COG1209 Cluster_429024 V1238174 RPLJ map03010 J 50s ribosomal protein L10 COG0244 Cluster_467255 V1238175 NRDG O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) COG0602 Cluster_417978 V1238176 S NA 0ZXDT Cluster_520457 V1238181 BAS0367 map02010 P Binding-protein-dependent transport systems, inner membrane component COG0600 Cluster_451028 V1238183 MERR2 K merR family transcriptional Regulator COG0789 Cluster_425211 V1238191 GLNQ E abc transporter atp-binding protein COG1126 Cluster_427131 V1238197 U, W Pfam:YadA COG5295 Cluster_520458 V1238198 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_549079 V1238202 L Topoisomerase COG0550 Cluster_429025 V1238203 FCL map00051,map00520,map01100 M Nad-dependent epimerase dehydratase COG0451 Cluster_431011 V1238208 MRP D ATP-binding protein COG0489 Cluster_851849 V1238213 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_439016 V1238215 S BioX protein 11WNI Cluster_434926 V1238217 S (ABC) transporter COG4152 Cluster_487323 V1238221 SP_0686 S bacteriocin-associated integral membrane protein COG4652 Cluster_913315 V1238222 REPA S Replication initiator protein 11GEP Cluster_904987 V1238225 PLSC map00561,map00564,map01100 I Acyl-transferase COG0204 Cluster_566982 V1238226 CELAL_0017 S NA 11TT6 Cluster_443006 V1238238 THRC map00260,map00750,map01100,map01120,map01230 E Threonine synthase COG0498 Cluster_669873 V1238239 L NA 0YQQ7 Cluster_444997 V1238242 S NA 0YDZN Cluster_449061 V1238247 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_447039 V1238248 FTSE map02010 D Cell division ATP-binding protein ftsE COG2884 Cluster_452975 V1238254 M nlpC P60 family protein COG0791 Cluster_456934 V1238267 ECSA V abc transporter atp-binding protein COG1131 Cluster_695974 V1238270 YXBA S ATP-grasp COG3919 Cluster_463089 V1238283 YLBE map00051,map00363,map00591,map00625,map00650,map01100,map01120 G, M epimerase dehydratase COG0702 Cluster_629136 V1238284 CSOR S protein, conserved in bacteria COG1937 Cluster_463090 V1238285 U, W Pfam:YadA COG5295 Cluster_471538 V1238303 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_509951 V1238313 S NA 11SYG Cluster_475799 V1238316 TGT J Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COG0343 Cluster_480395 V1238326 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_480397 V1238328 TTCA D Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) COG0037 Cluster_485037 V1238340 S NA 10111 Cluster_809224 V1238345 S NA 0ZGF4 Cluster_485038 V1238347 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_715045 V1238353 S NA 0XWWF Cluster_492170 V1238365 S Membrane 0Y3RG Cluster_489676 V1238366 THID map00730,map01100 H phosphomethylpyrimidine kinase COG0819 Cluster_551965 V1238367 S RelB antitoxin 12546 Cluster_492171 V1238368 S Rib/alpha-like repeat 0YK85 Cluster_678721 V1238370 LEXA K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) COG1974 Cluster_494659 V1238372 ASNB map00250,map00910,map01100,map01110,map01120 E Asparagine synthetase COG0367 Cluster_896374 V1238374 S NA 0ZHU9 Cluster_876018 V1238377 TRXB map00240,map00450 C ferredoxin--nadp reductase COG0492 Cluster_734753 V1238385 ARGG map00250,map00330,map01100,map01110,map01230 E Citrulline--aspartate ligase COG0137 Cluster_512519 V1238387 TOPB L Dna topoisomerase COG0550 Cluster_888137 V1238392 YJDB S NA 128F1 Cluster_502364 V1238393 TYRA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydrogenase COG0287 Cluster_599706 V1238394 S Addiction module antitoxin, RelB DinJ family 11X3K Cluster_573275 V1238404 S NA 0ZHU9 Cluster_674278 V1238405 O Matrixin COG5549 Cluster_509952 V1238412 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG2812 Cluster_793101 V1238417 L site-specific recombinase, phage integrase family 0ZJK4 Cluster_512520 V1238418 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_512521 V1238421 DNAQ map03420,map03430 L Uvrd rep helicase COG2176 Cluster_512522 V1238422 S NA 11S7H Cluster_570068 V1238423 L UPF0102 protein COG0792 Cluster_515224 V1238424 RUBY C Rubrerythrin COG1592 Cluster_625435 V1238425 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_512523 V1238426 GLNE O, T Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) COG1391 Cluster_512524 V1238428 S NA 101UU Cluster_515225 V1238429 SP_1222 V restriction endonuclease 0ZVJ1 Cluster_520459 V1238435 ACIN_0074 L Transposase COG3464 Cluster_731548 V1238436 LDTA S ErfK YbiS YcfS YnhG COG1376 Cluster_520460 V1238437 L Integrase COG0582 Cluster_523225 V1238441 S NA 0ZTYV Cluster_528895 V1238446 THETH_0161 L Transposase COG3328 Cluster_551966 V1238448 FTSI map00550,map01100 M penicillin-binding protein COG0768 Cluster_528896 V1238452 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_526135 V1238454 TYPA T gtp-binding protein typa COG1217 Cluster_534499 V1238455 COMEA L Competence protein COG1555 Cluster_528897 V1238456 S NA 0YDZN Cluster_657177 V1238460 ARGG map00250,map00330,map01100,map01110,map01230 E Citrulline--aspartate ligase COG0137 Cluster_797072 V1238463 S integral membrane protein 121K9 Cluster_800995 V1238464 SCRK map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G fructokinase COG1940 Cluster_661393 V1238469 S NA 11VFS Cluster_576496 V1238473 S NA 0YD8C Cluster_534500 V1238474 CLCAR_2696 S Membrane protein AbrB duplication COG3180 Cluster_637023 V1238478 RNC map03008,map05205 K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) COG0571 Cluster_540194 V1238480 CSN1 V CRISPR-associated 10TRZ Cluster_540195 V1238483 PURK map00230,map01100,map01110 F phosphoribosylaminoimidazole carboxylase atpase subunit COG0026 Cluster_543086 V1238484 L site-specific recombinase, phage integrase family 0ZJK4 Cluster_543088 V1238490 SP_0298 S ATPase (AAA COG1373 Cluster_617986 V1238492 YCHF J gtp-binding protein COG0012 Cluster_546037 V1238496 FTSK D cell division protein FtsK COG1674 Cluster_863980 V1238499 S NA 0Y1I8 Cluster_546038 V1238500 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_617987 V1238501 FUR P uptake regulator, fur family COG0735 Cluster_549083 V1238506 S Putative cell wall binding repeat 11WSW Cluster_554866 V1238520 F Permease family COG2233 Cluster_603277 V1238521 NDVA2 V ABC transporter, ATP-binding protein COG1132 Cluster_570069 V1238529 S domain protein 0Y1ZG Cluster_557768 V1238531 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_557769 V1238533 S NA 11WGF Cluster_563791 V1238547 PPK map00190,map03018 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) COG0855 Cluster_563792 V1238548 NUSA K Transcription elongation factor NusA COG0195 Cluster_563793 V1238550 WBYL map00532,map01100 M glycosyl transferase COG0463 Cluster_896376 V1238551 G, M Nucleoside-diphosphate-sugar epimerase COG0702 Cluster_589356 V1238552 SENX3 map02020 T Histidine kinase 0XNMH Cluster_563794 V1238553 THIG map00730,map01100 H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) COG2022 Cluster_867972 V1238554 L Inherit from COG: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_632976 V1238560 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_566985 V1238561 F Hydroxymethylpyrimidine transporter CytX COG1457 Cluster_566986 V1238562 GABD map00250,map00350,map00650,map01100,map01120 C Aldehyde dehydrogenase COG1012 Cluster_570070 V1238564 M Cell surface protein 11GRZ Cluster_570072 V1238566 S NA 0Y1Q6 Cluster_570073 V1238569 YHAM S UPF0597 protein COG3681 Cluster_617989 V1238573 S NA 0XUFW Cluster_576497 V1238574 YEGV G Kinase, PfkB family COG0524 Cluster_576498 V1238576 WHIA K May be required for sporulation (By similarity) COG1481 Cluster_621642 V1238578 FOLE map00790,map01100 H GTP cyclohydrolase i COG0302 Cluster_576499 V1238579 S NA 120HK Cluster_695975 V1238585 SP_0276 S addiction module toxin, RelE StbE family COG3041 Cluster_579613 V1238586 V abc transporter COG1136 Cluster_705418 V1238592 PACL2 P Atpase, p-type (Transporting), had superfamily, subfamily ic COG0474 Cluster_657178 V1238594 YDIM G Major Facilitator 0XRAD Cluster_586052 V1238597 YQAJ L phage-type endonuclease COG5377 Cluster_586053 V1238598 CSN1 L crispr-associated protein COG3513 Cluster_586055 V1238602 DNAG map03030 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 Cluster_617990 V1238603 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_589357 V1238606 S integral membrane protein 0XS1S Cluster_629137 V1238610 S NA 120XW Cluster_724956 V1238613 S NA 0ZHU9 Cluster_592718 V1238617 S haloacid dehalogenase-like hydrolase COG0561 Cluster_625436 V1238618 DCTP C symporter COG1301 Cluster_592719 V1238619 S NA 11VCX Cluster_592720 V1238621 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_592721 V1238625 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_596196 V1238627 RV3193C S UPF0182 protein COG1615 Cluster_917662 V1238629 S Sulfite exporter TauE/SafE COG0730 Cluster_599709 V1238636 YFNA E amino acid COG0531 Cluster_683268 V1238639 CCPA K catabolite control protein a COG1609 Cluster_599710 V1238640 PPNK map00760,map01100 G Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) COG0061 Cluster_648973 V1238641 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_603279 V1238643 GLMU map00520,map01100,map01110 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) COG1207 Cluster_603281 V1238645 ARCA map00330,map01100,map01110 E Arginine dihydrolase COG2235 Cluster_785301 V1238649 S NA 0ZHU9 Cluster_603282 V1238652 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_718289 V1238657 PFL C formate acetyltransferase COG1882 Cluster_606912 V1238658 THID map00730,map01100 H phosphomethylpyrimidine kinase COG0819 Cluster_610574 V1238662 SFUB map02010 P transporter (permease) COG1178 Cluster_610575 V1238663 MYCA S Myosin-Cross-Reactive Antigen COG4716 Cluster_610577 V1238667 S NA 122RP Cluster_614236 V1238675 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_614237 V1238676 K family Transcriptional regulator 0XUC3 Cluster_777440 V1238679 S NA 0ZT45 Cluster_617992 V1238683 PRFC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) COG4108 Cluster_617993 V1238684 S NA 0YBPX Cluster_621643 V1238686 XYLS map00052,map00500,map01100 G hydrolase, family 31 COG1501 Cluster_653053 V1238688 S Hydrolase COG4814 Cluster_621644 V1238692 S Membrane 0ZWF2 Cluster_621645 V1238693 PPSA map00620,map00680,map00720,map01100,map01120 G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) COG0574 Cluster_629140 V1238703 SCLAV_1000 S TPR-repeat-containing protein 10GX4 Cluster_629141 V1238704 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_699258 V1238706 AHPC O alkyl hydroperoxide reductase COG0450 Cluster_632978 V1238711 V ABC transporter, ATP-binding protein COG1132 Cluster_820815 V1238712 HSDM V type I restriction-modification system COG0286 Cluster_632979 V1238714 MALL map00500,map01100 G Oligo-1-6-glucosidase COG0366 Cluster_892245 V1238722 PSTS map02010,map02020,map05152 P phosphate COG0226 Cluster_632981 V1238723 S CAAX amino terminal protease family protein 0XUJM Cluster_637025 V1238725 YFLS P transporter COG0471 Cluster_840131 V1238726 K transcriptional regulator COG2378 Cluster_637028 V1238732 FLGG map02040 N flagellar COG4786 Cluster_641026 V1238735 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_641027 V1238736 S domain protein 0YF83 Cluster_637030 V1238740 RPH map00230,map00240,map01100 J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) COG0689 Cluster_687698 V1238741 SCLAV_3359 map02020 T Histidine kinase 0XNMH Cluster_644898 V1238746 S Rib/alpha-like repeat 10008 Cluster_644899 V1238748 S (LipO)protein COG3212 Cluster_644900 V1238749 NT5E map00230,map00240,map00630,map00760,map01100,map01110 S Hydrolase COG0546 Cluster_805195 V1238751 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_648974 V1238753 S NA 11QZ9 Cluster_648975 V1238754 S NA 11NI8 Cluster_648976 V1238755 METQ map02010 P (Lipo)protein COG1464 Cluster_836232 V1238756 TET38 P MFS family major facilitator transporter, tetracycline cation symporter COG0477 Cluster_653055 V1238759 S NA 11WG4 Cluster_653056 V1238760 M RHS repeat-associated core domain protein COG3209 Cluster_653057 V1238762 FAS map00061,map00350,map00362,map00627,map00642,map00903,map01100,map01120 I synthase COG4982 Cluster_653058 V1238764 ADHA map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120 C alcohol dehydrogenase COG1064 Cluster_657181 V1238768 C Nitroreductase COG0778 Cluster_748174 V1238769 S NA 0ZHU9 Cluster_657184 V1238777 SP_0319 G isomerase COG0698 Cluster_657185 V1238780 NUC L nuclease COG1525 Cluster_657186 V1238782 COMEB map00240,map01100 F deaminase COG2131 Cluster_657187 V1238783 MT2802 S atpase involved in dna repair 0XNTH Cluster_661395 V1238788 NIFJ map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map00910,map01100,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_661397 V1238790 FBA map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01230 G Fructose-1,6-bisphosphate aldolase, class II COG0191 Cluster_665595 V1238794 LDH map00010,map00051,map00270,map00363,map00591,map00620,map00625,map00640,map00650,map01100,map01110,map01120 C lactate/malate dehydrogenase, alpha/beta C-terminal domain COG0039 Cluster_728249 V1238795 S tm2 domain 11XDS Cluster_665596 V1238798 VSR L DNA mismatch endonuclease Vsr COG3727 Cluster_665597 V1238799 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_665598 V1238800 S repeat protein COG0457 Cluster_734755 V1238804 S NA 0YMVP Cluster_665599 V1238805 PDXS map00750 H Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) COG0214 Cluster_669876 V1238806 YTTB G Major Facilitator 0ZVV9 Cluster_669877 V1238807 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_758575 V1238808 MHPC map00240,map00330,map00362,map01100,map01120 S Alpha beta hydrolase COG0596 Cluster_669878 V1238809 CAMS S Sex pheromone COG4851 Cluster_669879 V1238812 FBA2 map00010,map00030,map00051,map00052,map00680,map00710,map01100,map01110,map01120,map01230 G aldolase COG0191 Cluster_674280 V1238813 SERB map00260,map00680,map01100,map01120,map01230 E phosphoserine phosphatase COG0560 Cluster_674281 V1238815 L DNA Methylase COG2189 Cluster_674282 V1238816 FTSX map02010 D Part of the ABC transporter FtsEX involved in cellular division (By similarity) COG2177 Cluster_708517 V1238817 DINB2 L ImpB MucB SamB family protein COG0389 Cluster_674283 V1238818 GLPQ map00564 C glycerophosphoryl diester phosphodiesterase COG0584 Cluster_674285 V1238825 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_678722 V1238828 CAS1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) COG1518 Cluster_678723 V1238829 map00561,map01100 M group 1 glycosyl transferase COG0438 Cluster_678725 V1238831 YCIB M ErfK YbiS YcfS YnhG COG1376 Cluster_777441 V1238836 T Universal stress protein COG0589 Cluster_766307 V1238839 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_734756 V1238840 INFA J however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) COG0361 Cluster_687699 V1238842 map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_683271 V1238844 CBIO2 map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_687704 V1238854 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_687706 V1238857 MT2100 map02010 G Binding-protein-dependent transport systems inner membrane component COG1175 Cluster_692201 V1238866 GAT map00230,map00983,map01100 F Glutamine amido-transferase COG0518 Cluster_728250 V1238867 GLTT C Transporter, dicarboxylate amino acid cation Na H symporter family protein COG1301 Cluster_269756 V1238872 CJAA map02010,map02020 E ABC transporter substrate-binding protein COG0834 Cluster_78409 V1238873 V ABC transporter COG1132 Cluster_114886 V1238874 M (sortase) family COG3764 Cluster_429027 V1238876 ATOB map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map02020 I Acetyl-CoA acetyltransferase COG0183 Cluster_215010 V1238879 S Protein of unknown function (DUF3137) 11MSU Cluster_8115 V1238880 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_436980 V1238881 S tm2 domain-containing protein 12AVU Cluster_1031 V1238882 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_377 V1238883 S NA 0ZTYV Cluster_252759 V1238887 LYC M glycoside hydrolase, family 25 11T0J Cluster_789315 V1238891 S Acetyltransferase (GNAT) family 0XV0I Cluster_14129 V1238893 S NA 101UU Cluster_77501 V1238895 H amine oxidase COG1232 Cluster_171977 V1238896 INLJ map05150 M Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps 1215X Cluster_101147 V1238902 GLMU map00520,map01100,map01110 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) COG1207 Cluster_107059 V1238903 PBUG S Xanthine uracil vitamin C permease COG2252 Cluster_12360 V1238906 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_16442 V1238908 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_563795 V1238911 S NA 0ZHU9 Cluster_23347 V1238914 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_497164 V1238915 map00051,map00520,map01100,map02060 G PTS system fructose IIA component COG2893 Cluster_273727 V1238918 LYC M glycoside hydrolase, family 25 11T0J Cluster_449062 V1238921 YHGE S domain protein COG1511 Cluster_98970 V1238922 S NA 11GMQ Cluster_77129 V1238923 M NA 0ZYVM Cluster_102265 V1238925 SCLAV_4792 G Major Facilitator superfamily 0XQD0 Cluster_429028 V1238927 YBAK S YbaK ebsC protein COG2606 Cluster_549084 V1238929 THID map00730,map01100 H phosphomethylpyrimidine kinase COG0351 Cluster_370357 V1238933 S NA 0ZHU9 Cluster_166160 V1238935 MUTT1 L NUDIX hydrolase COG0494 Cluster_377083 V1238936 PHOU P Plays a role in the regulation of phosphate uptake COG0704 Cluster_705422 V1238937 S NA 17D58@proNOG Cluster_69613 V1238940 S NA 11NI8 Cluster_371983 V1238946 S NA 0ZHU9 Cluster_132655 V1238949 S NA 0YSBI Cluster_108801 V1238957 U, W Pfam:YadA COG5295 Cluster_145724 V1238967 U, W Pfam:YadA COG5295 Cluster_252760 V1238971 OWEHO_0257 L Integrase COG2801 Cluster_170338 V1238976 INLJ map05150 M Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps 1215X Cluster_785302 V1238977 S NA 0ZHU9 Cluster_184698 V1238985 S NA 0YDZN Cluster_781192 V1238997 S NA 0ZHU9 Cluster_738113 V1238999 S ApbE family 11H27 Cluster_224347 V1239011 OCAR_5891 map00020,map00720,map01100,map01110,map01120,map05200,map05211 P iron permease COG0672 Cluster_678726 V1239013 S NA 0ZHU9 Cluster_292669 V1239015 ACIN_0074 L Transposase COG3464 Cluster_289996 V1239022 map00052,map00500,map01100 G hydrolase, family 31 COG1501 Cluster_326057 V1239024 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_271061 V1239025 RES_1 V type IIi COG3421 Cluster_273728 V1239028 M Mandelate racemase muconate lactonizing protein COG4948 Cluster_789317 V1239033 GND map00030,map00480,map01100,map01110,map01120 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) COG0362 Cluster_407086 V1239042 SCLAV_5050 map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_300855 V1239044 V Type I restriction enzyme R protein N terminus (HSDR_N) COG0610 Cluster_305191 V1239048 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_377084 V1239050 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_596197 V1239053 PSTA map02010 P phosphate abc transporter COG0581 Cluster_621647 V1239054 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_391172 V1239059 YNHI map00900,map01110 S heptaprenyl diphosphate synthase component I COG4769 Cluster_375317 V1239069 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_417979 V1239077 TNPR L resolvase COG1961 Cluster_362019 V1239081 THIM map00730,map01100 H 4-methyl-5-beta-hydroxyethylthiazole kinase COG2145 Cluster_389443 V1239085 S Conserved Protein COG4804 Cluster_465169 V1239088 S NA 0ZHU9 Cluster_365332 V1239094 L adenine specific DNA methylase COG2189 Cluster_509954 V1239097 RES_1 V type IIi COG3421 Cluster_439018 V1239099 K GntR Family Transcriptional Regulator COG2186 Cluster_431012 V1239104 S S-layer domain protein 11R54 Cluster_378865 V1239108 U, W Pfam:YadA COG5295 Cluster_592724 V1239111 TEH_07770 L reverse transcriptase COG3344 Cluster_487326 V1239114 S NA 0ZHU9 Cluster_385910 V1239117 S NA 11S7H Cluster_391173 V1239122 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_543090 V1239124 S NA 0ZHU9 Cluster_400043 V1239131 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_789319 V1239134 LDB1079 L integrase family COG0582 Cluster_731552 V1239135 S RelB antitoxin 12546 Cluster_396586 V1239136 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_715049 V1239141 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_405417 V1239144 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_896386 V1239161 FABI map00061,map00780,map01100 I Enoyl- acyl-carrier-protein reductase NADH COG0623 Cluster_705423 V1239162 S NA 0ZHU9 Cluster_419756 V1239164 P TonB-dependent Receptor Plug Domain protein COG4771 Cluster_705424 V1239171 S ABC transporter substrate-binding protein 0ZK3U Cluster_531718 V1239175 S NA 0ZHU9 Cluster_441005 V1239192 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_665600 V1239201 PRMA J Methylates ribosomal protein L11 (By similarity) COG2264 Cluster_463091 V1239211 S Inherit from COG: Virulence-associated protein e COG4983 Cluster_471539 V1239220 YJEE S protein family UPF0079, ATPase COG0802 Cluster_482716 V1239235 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_482717 V1239238 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_606914 V1239239 MT2794 M LGFP repeat protein COG5479 Cluster_625441 V1239248 S ATP-dependent endonuclease of the OLD 0Z1KF Cluster_531719 V1239259 S CHAP domain COG3942 Cluster_499831 V1239260 BL00144 L Transposase COG2801 Cluster_674286 V1239267 CPS1D map00051 S biosynthesis protein 0XQI4 Cluster_734759 V1239269 PIP map00330 L Prolyl aminopeptidase COG0596 Cluster_507353 V1239271 CTPF P ATPase, P-type (transporting), HAD superfamily, subfamily IC COG0474 Cluster_599711 V1239288 IUNH2 map00230,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_589361 V1239308 S NA 11VKF Cluster_540196 V1239312 S integral membrane protein 11Q41 Cluster_549086 V1239327 RIMO J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) COG0621 Cluster_840141 V1239328 S NA 0ZHU9 Cluster_905001 V1239329 DAPL map00300,map01100,map01110,map01230 H Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli (By similarity) COG0436 Cluster_657190 V1239331 S NA 0ZHU9 Cluster_551968 V1239333 SERA map00260,map00270,map00680,map01100,map01120,map01230 E phosphoglycerate dehydrogenase COG0111 Cluster_554867 V1239340 C oxidoreductase COG0604 Cluster_560822 V1239353 YFMR S Abc transporter COG0488 Cluster_563797 V1239354 TAUB map02010 P abc transporter COG1116 Cluster_566988 V1239358 HSDM V type I restriction-modification system COG0286 Cluster_734761 V1239359 S NA 0ZHU9 Cluster_566989 V1239360 M Cell surface protein 11GRZ Cluster_570075 V1239362 ASNB map00250,map00910,map01100,map01110,map01120 E asparagine synthetase COG0367 Cluster_570076 V1239366 UREE O Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) COG2371 Cluster_892255 V1239369 GREA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) COG0782 Cluster_859654 V1239372 S NA 0ZHU9 Cluster_576502 V1239376 U PbH1 0XQFW Cluster_576503 V1239377 TAGE M peptidase M23 COG0739 Cluster_758580 V1239383 AGCS E Sodium:alanine symporter family COG1115 Cluster_589362 V1239399 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_692206 V1239401 E CM_2 COG1605 Cluster_711667 V1239403 MUCPA_3532 L Transposase COG3547 Cluster_589363 V1239404 K Transcriptional regulator, GntR family COG1167 Cluster_596198 V1239407 MRP D ATP-binding protein COG0489 Cluster_644905 V1239413 GLPF G glycerol uptake facilitator protein COG0580 Cluster_599712 V1239415 AMYA2 map00500 G alpha amylase, catalytic 0XQRS Cluster_603283 V1239416 YDIM G Major Facilitator 0XRAD Cluster_777445 V1239417 RECU S Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) COG3331 Cluster_606915 V1239421 RES L resolvase COG1961 Cluster_744826 V1239423 WANG_1264 L Transposase COG2452 Cluster_606916 V1239425 YHGE S domain protein COG1511 Cluster_614240 V1239435 G carbohydrate kinase, YjeF related protein COG0062 Cluster_669883 V1239436 L Inherit from COG: transposase COG3464 Cluster_614241 V1239437 G Major Facilitator COG2814 Cluster_617997 V1239443 AMD E amidohydrolase COG1473 Cluster_625442 V1239455 RES_1 V type IIi COG3421 Cluster_625443 V1239456 MNME S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 Cluster_625444 V1239457 BIOW map00780,map01100 H Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) COG1424 Cluster_632983 V1239461 RSMI G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 Cluster_692207 V1239463 L Topoisomerase COG0550 Cluster_632984 V1239467 S NA 0YKQV Cluster_637033 V1239468 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_637034 V1239469 ARAQ map02010 P transporter COG0395 Cluster_738117 V1239471 S NA 0ZHU9 Cluster_637035 V1239473 VORB map00020,map00280,map00720,map01100,map01120 C Ferredoxin COG0674 Cluster_641029 V1239478 S Rib/alpha-like repeat 10008 Cluster_648980 V1239479 NOX map00190 P pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_785308 V1239491 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_661399 V1239505 NFSA map00051,map00190,map00363,map00591,map00625,map00633,map00650,map01100,map01120 C nitroreductase COG0778 Cluster_665603 V1239507 S NA 0YZ82 Cluster_741531 V1239510 YYCH S YycH protein COG4863 Cluster_669884 V1239511 ISPE map00900,map01100,map01110 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COG1947 Cluster_669885 V1239515 RV2326C map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_863992 V1239519 L NA 0ZR51 Cluster_744827 V1239531 map00051 M group 2 family COG0463 Cluster_683276 V1239534 YLBE map00051,map00363,map00591,map00625,map00650,map01100,map01120 G, M epimerase dehydratase COG0702 Cluster_683277 V1239537 RSMI G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 Cluster_687709 V1239544 MURF map00300,map00550,map01100 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) COG0770 Cluster_687710 V1239548 COBB map00860,map01100 H Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) COG1797 Cluster_692208 V1239549 TIG O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COG0544 Cluster_692209 V1239550 POTA map02010 E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COG3842 Cluster_731556 V1239553 S NA 0ZHU9 Cluster_699266 V1239555 HRM2_08390 L transposase (IS4 family) protein 0XQ88 Cluster_345764 V1239556 ACIN_0074 L Transposase COG3464 Cluster_19207 V1239557 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_185571 V1239559 LGAS_0572 L Integrase COG0582 Cluster_441006 V1239560 WZB T protein tyrosine phosphatase COG0394 Cluster_17011 V1239561 SCLAV_1560 map02010 P ABC transporter COG1122 Cluster_95708 V1239562 MALL map00500,map01100 G Oligo-1-6-glucosidase COG0366 Cluster_203977 V1239563 META map00270,map00920,map01100,map01110,map01230 E Homoserine O-transsuccinylase COG1897 Cluster_66861 V1239564 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_15901 V1239565 S Lipase (class 3) 0ZJUJ Cluster_2892 V1239566 S NA 11NI8 Cluster_741533 V1239567 RPMA map03010 J 50S ribosomal protein l27 COG0211 Cluster_14172 V1239568 XYLS map00052,map00500,map01100 G hydrolase, family 31 COG1501 Cluster_42955 V1239569 ACCA map00061,map01100 I carboxylase COG4770 Cluster_5048 V1239570 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_507354 V1239571 RPSM map03010 J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits COG0099 Cluster_36399 V1239574 map02010 P ABC transporter COG1131 Cluster_444998 V1239575 RODA map00550,map04112 D cell cycle protein COG0772 Cluster_18207 V1239576 HELY L helicase COG4581 Cluster_47699 V1239577 STHIM L DNA methylase COG2189 Cluster_272396 V1239578 map00750,map01100 C Aldo Keto reductase COG0667 Cluster_300856 V1239579 YLME F alanine racemase domain protein COG0325 Cluster_557770 V1239580 S NA 0ZHU9 Cluster_387742 V1239582 S NA 11QRM Cluster_433007 V1239583 SCLAV_1116 S metal-sulfur cluster biosynthetic COG2151 Cluster_28155 V1239584 CADA P heavy metal translocating p-type ATPase COG2217 Cluster_27780 V1239586 RV2326C map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_69263 V1239587 MURE map00300,map00550,map01100 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_661401 V1239588 S Proteins of 100 residues with WXG 124WQ Cluster_17012 V1239589 V ABC, transporter COG0577 Cluster_32199 V1239590 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_509957 V1239592 NRDR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) COG1327 Cluster_71829 V1239593 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_171978 V1239594 THIO map00730 E glycine oxidase COG0665 Cluster_115570 V1239595 PARB K parb-like partition protein COG1475 Cluster_333566 V1239597 RAIA J sigma 54 modulation protein ribosomal protein S30ea COG1544 Cluster_30585 V1239598 NRDE map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_443007 V1239599 RIMI S ribosomal-protein-alanine acetyltransferase COG0456 Cluster_29305 V1239603 PBP1A map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_11608 V1239604 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_641030 V1239605 CAS2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) COG3512 Cluster_35998 V1239608 GLGX map00500,map01100,map01110 G glycogen debranching enzyme glgx COG1523 Cluster_683279 V1239609 S Phage-Associated Protein COG3600 Cluster_124102 V1239610 HEMN map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_232446 V1239612 APPB map02010 P Binding-protein-dependent transport systems inner membrane component COG0601 Cluster_150458 V1239613 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_46727 V1239614 MALL map00052,map00500,map01100 G trehalose-6-phosphate hydrolase (EC 3.2.1.93) COG0366 Cluster_121396 V1239615 VEX1 V ABC transporter, permease COG0577 Cluster_192606 V1239616 THRB map00260,map01100,map01120,map01230 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) COG0083 Cluster_95709 V1239617 L Domain protein COG0507 Cluster_275084 V1239619 PEPD E Dipeptidase COG4690 Cluster_65106 V1239622 LYTC M hydrolase, family 25 COG3757 Cluster_252761 V1239623 PIP map00330 L Prolyl aminopeptidase COG0596 Cluster_357105 V1239627 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_144224 V1239628 DPRA L DNA protecting protein DprA COG0758 Cluster_26259 V1239629 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_133485 V1239630 PURT map00230,map00670,map01100,map01110 F Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR COG0027 Cluster_23788 V1239631 S NA 0ZTYV Cluster_49162 V1239632 V abc transporter COG1132 Cluster_403602 V1239633 V ABC transporter COG1132 Cluster_517897 V1239635 FMT S decarboxylase family COG1611 Cluster_38137 V1239640 YHGE S domain protein COG1511 Cluster_182094 V1239641 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_50764 V1239642 FADD15 map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG1022 Cluster_230105 V1239643 S CHAP domain COG3942 Cluster_78113 V1239644 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_427132 V1239645 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_88577 V1239646 RPSA map00900,map01100,map01110,map03010 J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) COG0539 Cluster_284497 V1239647 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_557771 V1239648 FUR P uptake regulator, fur family COG0735 Cluster_509958 V1239650 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_173717 V1239652 4HBD map00650 C NAD-dependent 4-hydroxybutyrate dehydrogenase COG1454 Cluster_163696 V1239657 S CHAP domain COG3942 Cluster_198903 V1239658 RV1823 S membrane associated protein COG3879 Cluster_87692 V1239661 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_139786 V1239662 S NA 0Y5S2 Cluster_35708 V1239663 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_319935 V1239665 S NA 125RT Cluster_531720 V1239666 THID map00730,map01100 H phosphomethylpyrimidine kinase COG0819 Cluster_60392 V1239667 M Cell wall anchor domain protein 11Q8J Cluster_100566 V1239670 D Maf-like protein COG0424 Cluster_487327 V1239671 RMUC S Dna recombination protein COG1322 Cluster_47291 V1239673 V abc transporter permease protein COG0577 Cluster_695977 V1239674 map00053,map01100,map01120,map02060 G IIb component COG3414 Cluster_57274 V1239675 MPHA S Aminoglycoside phosphotransferase 0YEJ0 Cluster_247751 V1239676 M hydrolase, family 25 COG3757 Cluster_77502 V1239677 S NA 102WG Cluster_285947 V1239678 map02010 P ABC transporter COG0395 Cluster_692211 V1239679 SOJ D Chromosome Partitioning Protein COG1192 Cluster_537394 V1239680 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_460968 V1239682 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_447040 V1239683 RV1480 S von Willebrand factor COG1721 Cluster_250325 V1239688 SCLAV_3420 map02010,map02020 V abc transporter COG1131 Cluster_566990 V1239689 M glycosyl transferase COG1215 Cluster_71830 V1239690 DPPA map02010 E ABC transporter substrate-binding protein COG4166 Cluster_80168 V1239691 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_105812 V1239693 GLNA map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG0174 Cluster_254013 V1239694 THRC map00260,map00750,map01100,map01120,map01230 E Threonine synthase COG0498 Cluster_74491 V1239696 E amino acid COG0531 Cluster_93303 V1239697 S DivIVA domain repeat protein 11XZ2 Cluster_289997 V1239698 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_128186 V1239700 LYTR2 K TRANSCRIPTIONal COG1316 Cluster_203978 V1239702 CZCD P cation diffusion facilitator family transporter COG1230 Cluster_119133 V1239703 map03420,map03430 L helicase COG3973 Cluster_79158 V1239704 S NA 0ZTYV Cluster_79795 V1239705 M NA 0ZYVM Cluster_330506 V1239707 map02020 K Transcriptional regulator COG2197 Cluster_94697 V1239710 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_95710 V1239711 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_131132 V1239712 SLGD_00086 S Ser Thr phosphatase family protein COG1409 Cluster_291308 V1239713 S Membrane 11NPN Cluster_368654 V1239715 NTH map03410 L endonuclease III COG0177 Cluster_212707 V1239716 map02010 P ABC transporter COG1131 Cluster_499832 V1239717 S NA 100RW Cluster_176961 V1239719 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_200898 V1239720 GLUD map02010 E amino acid AbC transporter COG0765 Cluster_191670 V1239723 MSRA S methionine sulfoxide reductase A 0YJ5R Cluster_744829 V1239724 S NA 0ZHU9 Cluster_502365 V1239725 GLUQ map00860,map00970,map01100,map01110 J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) COG0008 Cluster_494660 V1239726 SCLAV_4555 M peptidase COG0739 Cluster_112046 V1239727 S NA 0YG6V Cluster_216149 V1239728 PHEA map00400,map01100,map01110,map01230 E Prephenate dehydratase COG0077 Cluster_122161 V1239730 S NA 11VT6 Cluster_268419 V1239732 SCLAV_4792 G Major Facilitator superfamily 0XQD0 Cluster_307884 V1239733 DNAQ2 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit epsilon COG0847 Cluster_309297 V1239735 NFRA map00051,map00190,map00363,map00591,map00625,map00633,map00650,map01100,map01120 C nitroreductase COG0778 Cluster_125415 V1239736 U, W Pfam:YadA COG5295 Cluster_188186 V1239737 CAFA map03018 J ribonuclease COG1530 Cluster_283126 V1239739 S HD domain COG1418 Cluster_215011 V1239740 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_517898 V1239741 THYA map00240,map00670,map01100 F Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) COG0207 Cluster_138996 V1239743 LYSX map00970,map05150 J Membrane COG2898 Cluster_140522 V1239746 S Inherit from NOG: membrane-spanning 4-domains, subfamily A, member 14 153T6@plaNOG Cluster_141997 V1239749 S NA 101UU Cluster_144225 V1239750 S NA 11NI8 Cluster_330507 V1239752 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_190754 V1239754 map02010 P ABC transporter substrate-binding protein 0ZVT7 Cluster_153662 V1239755 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_241168 V1239758 S CHAP domain COG3942 Cluster_925549 V1239762 S atpase, aaa COG1373 Cluster_262982 V1239764 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_176962 V1239766 SCLAV_2116 M glycosyl transferase family 0XPWZ Cluster_485040 V1239767 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_237304 V1239768 PSAA map02010 P ABC transporter COG0803 Cluster_220822 V1239771 YCEG F aminodeoxychorismate lyase COG1559 Cluster_283127 V1239772 COAX map00770,map01100 K Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) COG1521 Cluster_751593 V1239773 HSDS V specificity COG0732 Cluster_458912 V1239774 S NA 0ZHU9 Cluster_187328 V1239776 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_367038 V1239777 SCLAV_4781 S Protein of unknown function (DUF3710) 11QDA Cluster_192607 V1239781 P binding-protein-dependent transport systems inner membrane Component COG4986 Cluster_551969 V1239784 RPLL map03010 J Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) COG0222 Cluster_715053 V1239787 PSTC map02010 P phosphate abc transporter COG0573 Cluster_285948 V1239789 TYRA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydrogenase COG0287 Cluster_210484 V1239791 GYRA2 L DNA topoisomerase IV subunit A COG0188 Cluster_423410 V1239794 CG3417 L nudix hydrolase COG0494 Cluster_579615 V1239795 S NA 0ZHU9 Cluster_225516 V1239799 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_225517 V1239800 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_620694 V1002201 S Inherit from COG: Membrane COG3601 Cluster_269475 V1002202 G Major facilitator superfamily 0XP7I Cluster_509241 V1002203 HISF map00340,map01100,map01110,map01230 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) COG0107 Cluster_501691 V1002205 CTSR K transcriptional regulator, ctsr COG4463 Cluster_220577 V1002206 PURF map00230,map00250,map01100,map01110 F glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_647838 V1002208 map03060,map03070 U Preprotein translocase subunit COG1862 Cluster_595175 V1002209 SCRA map00010,map00500,map00520,map02060 G Pts system COG2190 Cluster_509242 V1002210 SCRK map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G fructokinase COG1940 Cluster_324184 V1002211 BL01171 P hemerythrin hhe cation binding domain protein COG2461 Cluster_351715 V1002212 E Pfam:DapD_N COG2171 Cluster_239603 V1002213 S Glucan-binding protein C 0ZJN4 Cluster_477422 V1002214 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_342177 V1002215 SP_0058 K GntR family transcriptional regulator COG2188 Cluster_470948 V1002216 YTXK L Adenine-specific COG0827 Cluster_542201 V1002217 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_239604 V1002218 GK0308 L Transposase COG3464 Cluster_468842 V1002219 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_542202 V1002220 ATPC map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG0355 Cluster_227509 V1002222 M serine-type D-Ala-D-Ala carboxypeptidase COG1686 Cluster_321061 V1002223 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_342178 V1002226 TAUC map02010 P binding-protein-dependent transport systems inner membrane Component COG0600 Cluster_296529 V1002227 P C4-dicarboxylate transporter malic acid transport protein COG1275 Cluster_237009 V1002228 M Minor structural protein 0XPF3 Cluster_274775 V1002229 STRIC_0432 L Transposase (IS4 family 11HCS Cluster_319622 V1002234 K regulatoR COG0745 Cluster_262698 V1002235 NUSA K Transcription elongation factor NusA COG0195 Cluster_464652 V1002236 SCRB map00052,map00500,map01100 G sucrose-6-phosphate hydrolase COG1621 Cluster_499139 V1002237 SCRR K Sucrose operon repressor COG1609 Cluster_250043 V1002238 YTQA S Radical SAM Protein COG1242 Cluster_258789 V1002239 AROG map00400,map01100,map01110,map01230 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) COG0722 Cluster_258790 V1002240 YPFJ S zinc metallopeptidase COG2321 Cluster_232173 V1002241 MSRA O reductase COG0229 Cluster_233468 V1002242 SDHA map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map05134 C Succinate dehydrogenase (Flavoprotein subunit) COG1053 Cluster_233469 V1002243 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_417533 V1002244 LACM map00052,map00511,map00600,map01100 G beta-galactosidase small subunit COG3250 Cluster_319623 V1002245 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_504136 V1002246 GLPG S Rhomboid family COG0705 Cluster_470949 V1002247 FTHC map00670,map01100 H 5-formyltetrahydrofolate cyclo-ligase COG0212 Cluster_556949 V1002249 JDEN_2149 S Endodeoxyribonuclease RusA 0Y0ZF Cluster_428541 V1002251 TRPG map00230,map00400,map00983,map01100,map01110,map01230 E anthranilate synthase COG0512 Cluster_235833 V1002252 PEPX E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) 0XPUZ Cluster_277426 V1002253 YVGN C reductase COG0656 Cluster_442510 V1002254 HTRA O serine protease COG0265 Cluster_812147 V1002255 RLMH S Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) COG1576 Cluster_235834 V1002256 S Inherit from COG: 40-residue yvtn family beta-propeller repeat protein COG3391 Cluster_581908 V1002257 ACCC map00061,map00253,map00620,map00640,map00720,map01100,map01110,map01120 I acetyl-CoA carboxylase biotin carboxylase COG0439 Cluster_504137 V1002258 ACCD map00061,map00253,map00620,map00640,map00720,map01100,map01110,map01120 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) COG0777 Cluster_432532 V1002259 YWLG S UPF0340 protein COG4475 Cluster_489011 V1002260 RLMB map00340,map00350,map00624,map01120 J RNA methyltransferase TrmH family group 3 COG0566 Cluster_598775 V1002261 YQJA S Membrane COG4129 Cluster_238322 V1002262 SASA S Mediates binding to human platelets, possibly through a receptor-ligand interaction. Probably associated with virulence in endovascular infection (By similarity) 12CMI Cluster_695092 V1002263 HRCA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) COG1420 Cluster_444505 V1002264 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_239605 V1002266 CIAH map02020 T Histidine kinase COG0642 Cluster_239606 V1002267 GDH map00250,map00330,map00430,map00910,map01100 E Dehydrogenase COG2902 Cluster_239607 V1002268 LDH map00010,map00051,map00270,map00363,map00591,map00620,map00625,map00640,map00650,map01100,map01110,map01120 C Dehydrogenase COG0039 Cluster_371593 V1002270 ADDA L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation COG1074 Cluster_575628 V1002271 RPLQ map03010 J 50S ribosomal protein l17 COG0203 Cluster_493974 V1002272 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_581909 V1002273 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_499140 V1002274 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_240892 V1002275 P Cation transporting ATPase, C-terminus COG0474 Cluster_819618 V1002276 RPMB map03010 J 50S ribosomal protein l28 COG0227 Cluster_479774 V1002277 SP_1914 S Cell wall-active antibiotics response protein (DUF2154) 11V5T Cluster_458356 V1002278 map00250,map00460,map00910,map01100,map01110 E K01424 L-asparaginase EC 3.5.1.1 COG0252 Cluster_276125 V1002280 S transporter, permease protein 0Y935 Cluster_401359 V1002284 SEPF S Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) COG1799 Cluster_371594 V1002286 ISPA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_788333 V1002287 XSEB map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1722 Cluster_536613 V1002288 PURE map00230,map01100,map01110 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) COG0041 Cluster_299179 V1002289 PBP2A map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_878919 V1002290 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_444506 V1002291 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_287025 V1002293 CBIQ map02010 P Cobalt transport protein COG0619 Cluster_246231 V1002294 ADDA L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation COG1074 Cluster_350183 V1002295 K Transcriptional regulator 11NZX Cluster_878920 V1002296 RPSN map03010 J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) COG0199 Cluster_843109 V1002297 RPMG map03010 J 50S ribosomal protein L33 COG0267 Cluster_757679 V1002298 RPMB map03010 J 50s ribosomal protein l28 COG0227 Cluster_737143 V1002299 COAD map00770,map01100 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) COG0669 Cluster_358405 V1002300 YLBL T domain protein COG3480 Cluster_404929 V1002301 MALR map00473,map01100 K transcriptional regulator COG1609 Cluster_250044 V1002302 TYPA T gtp-binding protein typa COG1217 Cluster_299180 V1002303 CBIO1 map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_336242 V1002306 O Fn3-like domain (DUF1034) COG1404 Cluster_289736 V1002307 S integral membrane protein 11J5I Cluster_340714 V1002309 SCPA S Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) COG1354 Cluster_251282 V1002312 PABB map00790 E synthase component I COG0147 Cluster_250045 V1002314 M surface protein 1248X Cluster_525345 V1002316 map00052,map02060 G PTS System COG2893 Cluster_613191 V1002317 map00051,map00520,map01100,map02060 G PTS System COG3444 Cluster_804206 V1002319 RPMI map03010 J 50s ribosomal protein L35 COG0291 Cluster_605879 V1002320 RPLT map03010 J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) COG0292 Cluster_251283 V1002321 IGA O Immunoglobulin A1 protease 1214T Cluster_252463 V1002322 VPR O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_292338 V1002324 PGDA G Polysaccharide deacetylase COG0726 Cluster_253769 V1002325 PEPX E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) 0XPUZ Cluster_578693 V1002327 ASP S Alkaline-shock protein COG1302 Cluster_258791 V1002328 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_358406 V1002330 PARB K parb-like partition protein COG1475 Cluster_875002 V1002331 PRKC T serine threonine protein kinase COG2815 Cluster_322636 V1002332 STP T phosphatase COG0631 Cluster_256191 V1002333 APRE O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_256192 V1002334 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_256193 V1002335 S NA 111SV Cluster_269476 V1002337 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_296530 V1002338 NARH map00910,map01120,map02020 C nitrate reductase beta subunit COG1140 Cluster_257448 V1002339 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_258792 V1002340 M protein (LPxTG motif) COG4932 Cluster_343789 V1002341 LDCA V peptidase U61 LD-carboxypeptidase A COG1619 Cluster_539472 V1002344 S head-tail joining protein 0XW7K Cluster_883159 V1002345 S Phage head-tail joining protein 124IP Cluster_260098 V1002346 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_493975 V1002347 GALM map00010,map01110,map01120 G converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) COG2017 Cluster_598776 V1002348 AGAS map00250,map00520,map01100,map01110 M isomerase COG2222 Cluster_361613 V1002351 S Cell wall-active antibiotics response protein (DUF2154) COG4758 Cluster_303328 V1002352 PPAC map00190 C Manganese-dependent inorganic pyrophosphatase COG1227 Cluster_353406 V1002353 S NA 0XW2G Cluster_396174 V1002356 MRAY map00550,map01100 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) COG0472 Cluster_727293 V1002357 FTSI map00550,map01100 M penicillin-binding protein COG0768 Cluster_448549 V1002358 SIP S Surface immunogenic protein 11NUP Cluster_378432 V1002359 ARCB map00330,map01110,map01230 E Ornithine cyclodeaminase COG2423 Cluster_631873 V1002360 VICK map02020 T Histidine kinase 0XNMH Cluster_448550 V1002361 VICX map03013 S domain protein COG1235 Cluster_360046 V1002362 YABB map00340,map00350,map00624,map01120 L Methyltransferase COG4123 Cluster_812148 V1002363 YAZA L domain protein COG2827 Cluster_301932 V1002364 YLBM S UPF0348 protein COG1323 Cluster_536614 V1002365 K acetyltransferase COG0454 Cluster_686449 V1002366 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_265400 V1002367 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_456450 V1002368 BFRB map00860 P ferritin COG1528 Cluster_299181 V1002369 PURF map00230,map00250,map01100,map01110 F glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_266711 V1002370 P periplasmic solute binding protein COG0803 Cluster_266713 V1002372 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_452478 V1002373 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_266714 V1002374 XFP map00030,map00680,map00710,map01100,map01120 G Phosphoketolase COG3957 Cluster_647839 V1002377 EMRE P multidrug resistance protein COG2076 Cluster_268091 V1002378 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_698456 V1002380 LDB1079 L integrase family COG0582 Cluster_269477 V1002381 D ftsk spoIIIe COG1674 Cluster_430535 V1002382 EFP J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) COG0231 Cluster_720719 V1002383 ASP S alkaline shock protein COG1302 Cluster_401360 V1002384 POXB map00620,map01100 E acetolactate synthase COG0028 Cluster_387289 V1002385 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_307624 V1002386 MANN map00051,map00052,map00520,map01100,map02060 G PTS system mannose fructose sorbose family transporter subunit IID COG3716 Cluster_272073 V1002387 SP_2141 map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 G hydrolase, family 20 0XQYG Cluster_272074 V1002388 N, U Inherit from COG: flagellar rod assembly protein muramidase flgj COG1705 Cluster_303329 V1002389 S Membrane COG2339 Cluster_827673 V1002390 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_373221 V1002391 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_390776 V1002392 YGGP S Rhomboid family COG0705 Cluster_780006 V1002393 YGGP S Rhomboid family COG0705 Cluster_276126 V1002394 CTPE P ATPase, P-type (Transporting), HAD superfamily, subfamily IC COG0474 Cluster_273442 V1002395 BGAA map00040,map00052,map00500,map00511,map00531,map00600,map00860,map00944,map00983,map01100,map04142 G beta-galactosidase COG3250 Cluster_273443 V1002396 S NA 11E53 Cluster_342179 V1002397 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_273444 V1002398 FUCA1 map00511 G alpha-L-fucosidase EC 3.2.1.51 COG3669 Cluster_273445 V1002399 RRMJ J Hemolysin A COG1189 Cluster_545169 V1002400 GATB map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 Cluster_444562 V1023802 NRDR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) COG1327 Cluster_306296 V1023803 G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) COG0176 Cluster_306297 V1023804 map00190,map00680,map01100 C ATP synthase alpha beta family, nucleotide-binding domain protein COG1156 Cluster_306298 V1023805 L ATP-dependent endonuclease of the OLD COG3593 Cluster_908201 V1023807 RPMJ map03010 J 50S ribosomal protein L36 COG0257 Cluster_394353 V1023812 MSBA map02010 V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) COG1132 Cluster_924569 V1023813 BMUL_3355 map00362,map01100,map01120 S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) COG2128 Cluster_307657 V1023817 U, W Pfam:YadA COG5295 Cluster_668873 V1023822 Q Transferase COG2977 Cluster_450570 V1023824 PIMA M Glycosyl transferase (Group 1 COG0438 Cluster_309024 V1023826 ESSC D ftsk spoIIIe COG1674 Cluster_343822 V1023829 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_652012 V1023830 S Lysyl endopeptidase 1072U Cluster_342222 V1023832 GTO2 O Glutathione S-transferase COG0435 Cluster_484472 V1023835 YIDX S replicase EC 2.7 17QZ0@proNOG Cluster_310438 V1023838 THRC map00260,map00750,map01100,map01120,map01230 E threonine synthase COG0498 Cluster_643905 V1023839 S NA 11EII Cluster_310439 V1023841 map01053 Q non-ribosomal peptide synthetase COG1020 Cluster_788402 V1023842 GLTF M Involved in induction of the so-called NTR enzymes in response to nitrogen deprivation, as well as in glutamate biosynthesis. May mediate the glutamate-dependent repression of the GLT operon 17URP@proNOG Cluster_310440 V1023843 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_383747 V1023844 S Membrane 0Y0H4 Cluster_473128 V1023845 YQEG S had superfamily (subfamily IIIa) phosphatase COG2179 Cluster_310441 V1023847 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_454557 V1023850 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_310442 V1023851 ASA S Ceramidase 0XQWE Cluster_714247 V1023857 YJFY S UPF0379 protein yjfY 17GPM@proNOG Cluster_394354 V1023859 S Pfam:DUF1994 0XRWZ Cluster_311983 V1023860 L resolvase COG1961 Cluster_883223 V1023861 PURM map00230,map01100,map01110 F Phosphoribosylformylglycinamidine cyclo-ligase COG0150 Cluster_390815 V1023862 VP1725 T cbs domain and cyclic nucleotide-regulated nucleotidyltransferase COG2905 Cluster_454558 V1023863 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_417563 V1023864 L Pfam:Transposase_7 COG4644 Cluster_313433 V1023865 P tonB-dependent receptor plug 0XT9Q Cluster_389069 V1023870 L resolvase 11YIU Cluster_816062 V1023871 L NA 11GDS Cluster_486786 V1023872 S NA 0ZBXI Cluster_673141 V1023874 S Ragb susd domain-containing protein 0XTE0 Cluster_710831 V1023876 map00480,map00980,map00982,map05204 O Glutathione S-transferase 179M0@proNOG Cluster_330212 V1023879 HS_0486 L transposase COG0675 Cluster_548291 V1023882 RPSA map00900,map01100,map01110,map03010 J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) COG0539 Cluster_542266 V1023883 BL05128 S Pfam:DUF646 0Y1C1 Cluster_761350 V1023885 L Integrase core domain protein COG2801 Cluster_383748 V1023887 INFC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) COG0290 Cluster_673142 V1023891 HYPC O Hydrogenase assembly chaperone hypC hupF COG0298 Cluster_410264 V1023893 S NA 11JP6 Cluster_609629 V1023894 CAS2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) COG3512 Cluster_704627 V1023896 PGN_0051 S NA 0YP2S Cluster_496552 V1023898 RPSG map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) COG0049 Cluster_924570 V1023899 S NA 0YZ82 Cluster_410265 V1023901 RPOE K RNA Polymerase 0XT41 Cluster_426674 V1023902 S glycosyltransferase 0Y8FN Cluster_639985 V1023904 YLXM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) COG2739 Cluster_313434 V1023905 S NA 0YG6V Cluster_765309 V1023906 S NA 16YNC@proNOG Cluster_315023 V1023908 CMK map00240,map00410,map00770,map01100,map01110 F Cytidine monophosphate kinase COG0283 Cluster_366694 V1023909 CHRA P Chromate transporter, chromate ion transporter (CHR) family COG2059 Cluster_358446 V1023910 GPMA map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0588 Cluster_740692 V1023913 LWE1937 S Conserved Protein COG4495 Cluster_486787 V1023914 S integral membrane protein COG3610 Cluster_454559 V1023915 YACP J Tetracycline resistance protein COG3688 Cluster_448587 V1023917 map04112 S NA 11ZVJ Cluster_316587 V1023920 YFMD map02010 P transport system permease protein COG0609 Cluster_380180 V1023922 S integral membrane protein 11JQ4 Cluster_426675 V1023923 MVAK2 map00900,map01100,map01110 I Phosphomevalonate kinase COG1577 Cluster_316588 V1023925 GYRA L DNA gyrase subunit a COG1372 Cluster_361656 V1023926 PCAD map00362,map01100,map01120 Q 3-oxoadipate enol-lactonase COG0596 Cluster_698526 V1023928 CLPS O Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) COG2127 Cluster_321097 V1023936 S membrane 0XT2N Cluster_557019 V1023941 HSDM V N-6 DNA Methylase COG0286 Cluster_823828 V1023948 RPMD map03010 J 50S ribosomal protein L30 0XUY8 Cluster_491600 V1023950 U Biopolymer transport protein exbD tolR 11GVS Cluster_403191 V1023952 PTH J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) COG0193 Cluster_796122 V1023953 S Protein of unknown function (DUF1320) 12DBA Cluster_336286 V1023955 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_318130 V1023956 MT1283 map00051,map00071,map00280,map00363,map00591,map00625,map00650,map01100,map01110,map01120 S short-chain dehydrogenase reductase 173MI@proNOG Cluster_761351 V1023957 TYRB map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aromatic amino acid aminotransferase COG1448 Cluster_318131 V1023958 ATPA map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_371635 V1023962 BL00969 S NA 0XYM3 Cluster_318132 V1023963 GUAB1 map00230,map00983,map01100,map01110 F Dehydrogenase COG0517 Cluster_383749 V1023964 SP_2027 S MORN repeat protein COG4642 Cluster_376675 V1023966 DSUI_1508 L AtP-binding protein COG1484 Cluster_319665 V1023967 VMRA V Mate efflux family protein COG0534 Cluster_695150 V1023969 LPXB map00540,map01100 M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) COG0763 Cluster_360092 V1023970 map02010 P ABC, transporter COG1108 Cluster_664537 V1023972 TRXA O Thioredoxin COG0526 Cluster_330213 V1023973 RLX U relaxase mobilization nuclease domain protein COG3843 Cluster_479828 V1023974 YXCA I coA-substrate-specific enzyme activase COG3581 Cluster_475253 V1023978 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_724163 V1023979 SPEG map00330,map00350,map00362,map00627,map00642,map00903,map01100,map01120 K gCN5-related N-acetyltransferase COG0454 Cluster_591859 V1023980 YEAO S MarR family Transcriptional regulator COG3189 Cluster_454560 V1023981 PYRR map00240,map01100 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) COG2065 Cluster_387329 V1023984 MURD map00471,map00550,map01100 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COG0771 Cluster_456487 V1023985 BIOY map02010 S bioY protein COG1268 Cluster_361657 V1023986 UDP map00240,map00983,map01100 F Phosphorylase COG2820 Cluster_816063 V1023987 BMUL_2130 S (Lipo)protein 17FJR@proNOG Cluster_496553 V1023988 S Family of unknown function (DUF490) COG2911 Cluster_421156 V1023992 PHOR map02020 T Histidine kinase 0XNMH Cluster_321098 V1023993 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_566163 V1023994 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_643906 V1023995 CARA map00240,map00250,map01100 F carbamoyl-phosphate synthetase glutamine chain COG0505 Cluster_321099 V1023996 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_396213 V1023997 LEMA S LemA family COG1704 Cluster_557772 V1239801 YCCF S Membrane COG3304 Cluster_431013 V1239805 AMYE map02010 G solute-binding protein COG1653 Cluster_287357 V1239807 YCHF J gtp-binding protein COG0012 Cluster_401826 V1239810 PYRK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) COG0543 Cluster_246494 V1239812 S Inherit from NOG: domain protein 0XXVB Cluster_254014 V1239816 M Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) COG1807 Cluster_433008 V1239817 MRAY map00550,map01100 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) COG0472 Cluster_295456 V1239818 YEBC K transcriptional regulatory protein COG0217 Cluster_264362 V1239823 S Phage minor structural protein, N-terminal domain protein 11ZGW Cluster_473645 V1239824 MVAS map00072,map00280,map00650,map00900,map01100,map01110 I Hydroxymethylglutaryl-CoA synthase COG3425 Cluster_265691 V1239828 SSCG_01435 E ABC transporter COG0765 Cluster_546039 V1239833 S Membrane COG3601 Cluster_312267 V1239834 S ATPase (AAA COG1373 Cluster_288709 V1239837 M Sortase family COG3764 Cluster_781202 V1239838 S FMN_bind 12BR0 Cluster_288710 V1239840 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_384134 V1239841 PROB map00330,map01100,map01230 E Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) COG0263 Cluster_777448 V1239842 S NA 0ZHU9 Cluster_291309 V1239846 MT3296 L helicase COG0210 Cluster_734766 V1239847 P Binding-protein-dependent transport systems inner membrane component COG0601 Cluster_302234 V1239849 GLF M udp-galactopyranose mutase COG0562 Cluster_298196 V1239852 P periplasmic solute binding protein COG0803 Cluster_367039 V1239854 S Endonuclease Exonuclease phosphatase 11H83 Cluster_785310 V1239856 V Hnh endonuclease COG1403 Cluster_306575 V1239857 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_333567 V1239859 ISCU C SUF system FeS assembly protein COG0822 Cluster_329107 V1239862 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_313761 V1239864 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_316871 V1239866 YJJK S ABC transporter, ATP-binding protein COG0488 Cluster_405418 V1239872 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_350586 V1239875 S abc transporter atp-binding protein COG4721 Cluster_394810 V1239876 SCLAV_4715 S type i phosphodiesterase nucleotide pyrophosphatase COG1524 Cluster_329108 V1239877 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_403603 V1239878 L HELICc COG0513 Cluster_332065 V1239880 KUP P Transport of potassium into the cell (By similarity) COG3158 Cluster_363587 V1239888 map00730,map01100 H thiamine COG1564 Cluster_695979 V1239891 YBIR P transporter COG0471 Cluster_427133 V1239894 M Inherit from NOG: domain protein 18B9F@proNOG Cluster_674292 V1239895 FMT S decarboxylase family COG1611 Cluster_357106 V1239897 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_362020 V1239898 M (sortase) family COG3764 Cluster_477993 V1239903 BAS0367 map02010 P Binding-protein-dependent transport systems, inner membrane component COG0600 Cluster_371985 V1239904 P Chloride channel COG0038 Cluster_371986 V1239905 M glycosyl transferase COG1215 Cluster_373603 V1239906 E, G Membrane COG0697 Cluster_436982 V1239913 SCLAV_1116 S metal-sulfur cluster biosynthetic COG2151 Cluster_398306 V1239920 T UspA domain-containing protein COG0589 Cluster_392986 V1239922 YKII S NA 11GTZ Cluster_398307 V1239924 CAFA map03018 J ribonuclease COG1530 Cluster_401828 V1239929 PROA map00330,map01100,map01230 E Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) COG0014 Cluster_695980 V1239930 S NA 0ZHU9 Cluster_421550 V1239932 S Filamentation induced by cAMP protein fic COG3177 Cluster_405419 V1239933 ASD map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) COG0136 Cluster_407087 V1239935 SCLAV_5050 map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_416174 V1239938 GND map00030,map00480,map01100,map01110,map01120 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) COG0362 Cluster_683280 V1239941 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_417980 V1239944 S NA 0ZUV9 Cluster_499833 V1239949 OPPCD E, P abc transporter COG1173 Cluster_421551 V1239950 K laci family transcriptional regulator COG1609 Cluster_423411 V1239954 map00730,map01100 H thiamine COG1564 Cluster_793109 V1239956 MT1053 D Septum formation initiator family protein COG1507 Cluster_534505 V1239957 K Inherit from COG: Transcriptional regulator COG2865 Cluster_517899 V1239966 S NA 0ZHU9 Cluster_828602 V1239967 RPMD map03010 J 50S ribosomal protein L30 COG1841 Cluster_434927 V1239972 TNP7109-5 L transposase COG2801 Cluster_592726 V1239976 S NA 125EB Cluster_549088 V1239985 U Secretion system protein COG4962 Cluster_447041 V1239987 THRC map00260,map00750,map01100,map01120,map01230 E Threonine synthase COG0498 Cluster_449063 V1239988 AROA map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate synthase COG0128 Cluster_537396 V1239989 G Major Facilitator 0XP2I Cluster_497165 V1239991 MENA map00130,map01100,map01110 H 1,4-dihydroxy-2-naphthoate octaprenyltransferase COG1575 Cluster_451029 V1239992 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_452976 V1239994 S NA 0YG6V Cluster_452977 V1239996 FAS map00061,map00350,map00362,map00627,map00642,map00903,map01100,map01120 I synthase COG4982 Cluster_523227 V1239997 S von Willebrand factor type 11R5D Cluster_454993 V1239998 UVRD2 map03420,map03430 L helicase COG2887 Cluster_566991 V1239999 S NA 0YRUB Cluster_454994 V1240001 LOLD V abc transporter atp-binding protein COG1136 Cluster_454995 V1240003 M Glycosyl transferase family 2 COG0463 Cluster_458915 V1240006 GLGB map00500,map01100,map01110 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) COG0296 Cluster_458916 V1240007 MRCB map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_460969 V1240009 XERD L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_502366 V1240013 S NA 11FFJ Cluster_460970 V1240014 ADHE map00010,map00051,map00071,map00350,map00362,map00363,map00591,map00620,map00621,map00622,map00625,map00626,map00650,map01100,map01110,map01120 C Dehydrogenase COG1454 Cluster_507355 V1240022 S Toxin-antitoxin system, antitoxin component, HicB family 11KI8 Cluster_492173 V1240027 M Cell surface protein 11GRZ Cluster_526137 V1240029 GYRA2 L DNA topoisomerase IV subunit A COG0188 Cluster_473646 V1240032 OPPC2 map02010 P Binding-protein-dependent transport systems inner membrane component COG1173 Cluster_475801 V1240033 YFNA E amino acid COG0531 Cluster_832359 V1240040 S NA 127RR Cluster_512525 V1240062 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_499834 V1240064 M Glycosyl transferase family 2 COG0463 Cluster_497166 V1240065 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_840146 V1240066 CRT map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00630,map00640,map00650,map00720,map00903,map00930,map01100,map01110,map01120 I 3-hydroxybutyryl-CoA dehydratase COG1024 Cluster_801015 V1240073 CLCAR_1091 T Histidine kinase COG0642 Cluster_507356 V1240075 S NA 0ZP3E Cluster_637037 V1240076 S NA 0ZHU9 Cluster_512526 V1240083 GLPA map00564,map00730 C fad dependent oxidoreductase COG0579 Cluster_913329 V1240087 L Addiction module antitoxin, RelB DinJ family COG3077 Cluster_618000 V1240091 YTJA S Could be involved in insertion of integral membrane proteins into the membrane (By similarity) COG0759 Cluster_515228 V1240092 G Aamy_C COG1523 Cluster_576505 V1240094 JAG S Single-stranded nucleic acid binding R3H domain-containing protein COG1847 Cluster_797080 V1240095 OCAR_4103 S cupin superfamily protein COG3542 Cluster_520461 V1240099 WBTF map00052,map00520,map01100,map01110 M Nad-dependent epimerase dehydratase COG0451 Cluster_629144 V1240101 map02010 P ABC transporter COG1122 Cluster_520462 V1240103 L Integrase core domain protein COG2801 Cluster_563799 V1240107 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_534506 V1240117 E, G Membrane COG0697 Cluster_534507 V1240118 RSMG M Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) COG0357 Cluster_573278 V1240123 CSPB K Cold shock protein COG1278 Cluster_537397 V1240126 M Cell wall anchor domain protein 11Q8J Cluster_789329 V1240128 S NA 0ZHU9 Cluster_543094 V1240131 L Topoisomerase COG0550 Cluster_738122 V1240134 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_546040 V1240135 S phage protein 0XQDU Cluster_549089 V1240141 K GntR Family Transcriptional Regulator COG2188 Cluster_758581 V1240143 S NA 0ZHU9 Cluster_913331 V1240153 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_557774 V1240154 M Inherit from NOG: domain protein 0XQTW Cluster_573279 V1240155 PTH J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) COG0193 Cluster_582858 V1240157 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_563802 V1240159 map02010 V ATP-binding protein COG4608 Cluster_566993 V1240161 DGT map00230 F deoxyguanosinetriphosphate triphosphohydrolase-like protein COG0232 Cluster_570078 V1240167 S NA 11QZ9 Cluster_789330 V1240169 S NA 125T8 Cluster_579616 V1240173 RPSE map03010 J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) COG0098 Cluster_579618 V1240178 S Uncharacterised protein family (UPF0233) 0ZZV4 Cluster_711669 V1240180 E extracellular solute-binding protein COG0834 Cluster_579620 V1240181 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_629145 V1240182 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_582861 V1240189 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_632988 V1240192 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_592728 V1240197 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_692212 V1240201 S NA 0Y18N Cluster_599714 V1240206 BOPA E Extracellular solute-binding protein, family 5 COG0747 Cluster_711670 V1240212 S NA 0ZPY9 Cluster_606918 V1240219 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_614246 V1240233 map02010 P ABC transporter substrate-binding protein COG0715 Cluster_621654 V1240245 RIHB map00230,map00240,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_801019 V1240247 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_625446 V1240249 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_625447 V1240250 S Rib/alpha-like repeat 10008 Cluster_629146 V1240255 PILT N, U twitching motility protein COG2805 Cluster_855638 V1240258 S NA 0ZHU9 Cluster_637038 V1240259 YNHH map00900,map01110 S protein, conserved in bacteria COG5341 Cluster_632989 V1240261 M phosphoglycerol transferase COG1368 Cluster_637039 V1240262 MT2802 S atpase involved in dna repair 0XNTH Cluster_641033 V1240273 C radical SAM domain protein COG1032 Cluster_644913 V1240280 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120 G phosphohexose isomerase COG0166 Cluster_648984 V1240281 GATA map00970,map01100 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) COG0154 Cluster_648985 V1240282 map00511,map00600,map04142 G BNR Asp-box repeat protein COG4409 Cluster_648986 V1240284 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_665607 V1240287 S NA 0ZHU9 Cluster_648988 V1240288 RPE map00030,map00040,map00710,map01100,map01110,map01120,map01230 G ribulose-phosphate 3-epimerase COG0036 Cluster_657193 V1240291 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_657195 V1240295 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_653067 V1240296 SPL M P60 family COG0791 Cluster_661404 V1240300 WHIA K May be required for sporulation (By similarity) COG1481 Cluster_678730 V1240301 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG1754 Cluster_724961 V1240309 S von Willebrand factor type 11R5D Cluster_665610 V1240311 RARA L recombination factor protein RarA COG2256 Cluster_669889 V1240315 OPPD S ABC transporter COG4172 Cluster_669890 V1240317 L RecA-family ATPase COG3598 Cluster_669891 V1240318 SP_0742 S degv family COG1307 Cluster_669893 V1240321 MNAA map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_674294 V1240327 S Addiction module antitoxin, RelB DinJ family 11X3K Cluster_773724 V1240331 M Peptidoglycan-binding domain 1 protein COG3409 Cluster_718294 V1240337 L Topoisomerase COG0550 Cluster_683282 V1240338 G Major Facilitator superfamily 0XT9M Cluster_683283 V1240339 PSTA map02010 P phosphate ABC transporter, permease COG0581 Cluster_683285 V1240341 S NA 0Y3CU Cluster_683286 V1240342 L Transposase 11M0T Cluster_913333 V1240346 YHBY J Rna-binding protein COG1534 Cluster_692213 V1240349 SCLAV_4722 J Methyltransferase COG2813 Cluster_692214 V1240353 YACP J Tetracycline resistance protein COG3688 Cluster_718295 V1240357 S NA 0ZHU9 Cluster_94698 V1240359 S S-layer domain protein 11R54 Cluster_12000 V1240360 U, W domain protein COG5295 Cluster_2151 V1240361 S NA 0YG6V Cluster_9911 V1240363 O cysteine protease COG4870 Cluster_177798 V1240364 RSGA G May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) COG1162 Cluster_370358 V1240366 S NA 126GD Cluster_1058 V1240368 S NA 11SX6 Cluster_141998 V1240369 map02060 G PTS system COG1455 Cluster_188187 V1240371 SPAK T Histidine kinase COG0642 Cluster_48764 V1240372 S NA 0ZZR9 Cluster_130345 V1240373 RESD map02020 T Two component transcriptional regulator, winged helix family COG0745 Cluster_367040 V1240374 PNCA map00760,map01100 Q isochorismatase COG1335 Cluster_2241 V1240375 MT3296 L helicase COG0210 Cluster_47114 V1240376 S Membrane COG0628 Cluster_219635 V1240378 S Endonuclease Exonuclease phosphatase 11H83 Cluster_17067 V1240381 CTPE P ATPase, P-type (Transporting), HAD superfamily, subfamily IC COG0474 Cluster_112772 V1240382 S Putative cell wall binding repeat 0YEGX Cluster_326058 V1240384 map02010 V ABC-2 type transporter 0XQ7R Cluster_485042 V1240385 K Sigma54 specific transcriptional regulator, Fis family COG3829 Cluster_310748 V1240386 JAG S Single-stranded nucleic acid binding R3H domain-containing protein COG1847 Cluster_53282 V1240387 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_71238 V1240390 FTSW map04112 D Cell division protein, FtsW COG0772 Cluster_64287 V1240391 E Dipeptide ABC transporter periplasmic component-like protein COG0747 Cluster_56506 V1240392 YPWA E carboxy-peptidase COG2317 Cluster_128187 V1240393 map02060 G cellobiose-specific IIC component COG1455 Cluster_205059 V1240394 S PASTA 0ZKZ3 Cluster_625448 V1240395 S single-strand binding family protein 0XS6K Cluster_463092 V1240396 S phage P1-related protein 126GA Cluster_358776 V1240397 RLFA S NA 11FRV Cluster_172892 V1240399 S NA 0YDJM Cluster_699268 V1240400 L Integrase core domain protein COG2801 Cluster_8293 V1240401 U, W Pfam:YadA COG5295 Cluster_2021 V1240404 S NA 0YG6V Cluster_339575 V1240405 SCLAV_4555 M peptidase COG0739 Cluster_133486 V1240406 PURT map00230,map00670,map01100,map01110 F Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR COG0027 Cluster_245173 V1240407 S NA 124K8 Cluster_210485 V1240408 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_417981 V1240409 S integral membrane protein 11P1U Cluster_56507 V1240410 MDLB5 map02010 V ABC transporter transmembrane region COG1132 Cluster_173718 V1240411 S NA 11PZ8 Cluster_187329 V1240414 S ApbE family 11H27 Cluster_14514 V1240415 PRIA map03440 L Primosomal protein n' COG1198 Cluster_227777 V1240416 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate (By similarity) COG0167 Cluster_193492 V1240418 S Single-stranded nucleic acid binding R3H COG1847 Cluster_414404 V1240420 S Domain of unknown function (DUF955) 0ZI1U Cluster_665611 V1240421 K DNA-binding helix-turn-helix protein 0XUC3 Cluster_43491 V1240422 V restriction endonuclease 0XQN3 Cluster_32853 V1240423 DAM map03430 L Adenine-specific COG3392 Cluster_95711 V1240424 S Inherit from NOG: Relaxase/Mobilisation nuclease domain 0XT8X Cluster_477995 V1240425 S Inherit from COG: Virulence-associated protein e COG4983 Cluster_520463 V1240426 S Inherit from COG: Virulence-associated protein e COG4983 Cluster_32854 V1240427 S Uncharacterized conserved protein (DUF2075) COG3410 Cluster_358777 V1240428 S NA 12BYI Cluster_238620 V1240429 O Secreted protein COG1651 Cluster_21626 V1240430 S Inherit from NOG: Histidine triad protein 11G35 Cluster_546041 V1240431 S NA 0Z8PS Cluster_237305 V1240432 RIBD map00740,map01100 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) COG0117 Cluster_471540 V1240433 RECX S regulatory protein RecX 11Y5X Cluster_230107 V1240434 S Membrane 0XQNE Cluster_1468 V1240435 S cell wall surface anchor family protein 0XRFZ Cluster_44838 V1240438 S Relaxase mobilization nuclease 0ZJJJ Cluster_190755 V1240439 S NA 11YT1 Cluster_7752 V1240440 S NA 11YT1 Cluster_152892 V1240441 S NA 0ZJ23 Cluster_375318 V1240445 DNAC L DNA replication protein COG1484 Cluster_232447 V1240446 S NA 0XV8P Cluster_27693 V1240452 S Inherit from COG: leucine Rich Repeat COG4886 Cluster_15104 V1240453 SCLAV_1560 map02010 P ABC transporter COG1122 Cluster_53784 V1240454 V type I restriction-modification COG0286 Cluster_26151 V1240455 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG2812 Cluster_92816 V1240457 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_73150 V1240460 UVRD map03420,map03430 L Helicase COG0210 Cluster_47292 V1240461 MPHA S Aminoglycoside phosphotransferase 0YEJ0 Cluster_73860 V1240462 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_4547 V1240464 SP_1222 V restriction endonuclease 0ZVJ1 Cluster_33120 V1240465 S Uncharacterized conserved protein (DUF2075) COG3410 Cluster_336600 V1240466 NUCS L Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) COG1637 Cluster_23690 V1240468 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG2812 Cluster_11094 V1240469 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_174529 V1240470 M Sortase family COG3764 Cluster_370 V1240471 S NA 101UU Cluster_77130 V1240473 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_206143 V1240474 HOLA map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III delta subunit COG1466 Cluster_60654 V1240477 PPX map00230 F, P ppx gppa phosphatase COG1507 Cluster_487328 V1240479 L DNA binding domain protein, excisionase family 12298 Cluster_436984 V1240480 S NA 11JGF Cluster_24469 V1240484 RV2326C map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_69264 V1240485 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_531721 V1240487 RUVX L Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) COG0816 Cluster_741536 V1240488 YRZL S UPF0297 protein COG4472 Cluster_89063 V1240489 S NA 0Z3Y8 Cluster_179508 V1240490 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_81755 V1240492 S Inherit from NOG: LPXTG-motif cell wall anchor domain protein 0YEBJ Cluster_115571 V1240493 S Transporter 0XRCT Cluster_236 V1240494 FAS map00061,map01100 I fatty acid synthase COG4982 Cluster_40074 V1240495 S NA 129FA Cluster_2170 V1240496 S NA 0ZTYV Cluster_427134 V1240497 NQR S Nadph-dependent fmn reductase COG0431 Cluster_11501 V1240498 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_30233 V1240499 S Putative cell wall binding repeat 0YEGX Cluster_227778 V1240500 S HpcH/HpaI aldolase/citrate lyase family 0XQQM Cluster_546042 V1240505 FEOA P FeoA domain protein 12273 Cluster_517901 V1240506 K Transcriptional regulator, arsr family COG0640 Cluster_209409 V1240507 RIHB map00230,map00240,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_192608 V1240509 OPPC P Binding-protein-dependent transport systems inner membrane component COG1173 Cluster_34637 V1240510 OPPD map02010 S ABC transporter COG1123 Cluster_55001 V1240511 V abc transporter COG1132 Cluster_378866 V1240512 V abc transporter atp-binding protein COG1131 Cluster_477996 V1240514 SG1639 S Phage-Associated Protein COG3600 Cluster_128188 V1240516 BL01323 M Cell wall binding repeat 2-containing protein 0ZKZU Cluster_1830 V1240518 SURB S G5 domain protein 0ZVV3 Cluster_3862 V1240520 S Cell surface protein 0ZXQA Cluster_255224 V1240521 RBSK map00030 G ribokinase COG0524 Cluster_220824 V1240522 YVBT C Luciferase family COG2141 Cluster_271063 V1240523 PAP L polyphosphate kinase 2 COG2326 Cluster_99493 V1240525 MURE map00300,map00550 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_170339 V1240526 YJIM E 2-hydroxyglutaryl-CoA dehydratase COG1775 Cluster_101148 V1240527 M polysaccharide biosynthesis protein COG2244 Cluster_497167 V1240528 BL01774 map00053,map01100,map01120,map02060 G IIa component COG1762 Cluster_115572 V1240529 ULAA map00053,map01100,map01120,map02060 G PTS system ascorbate-specific transporter subunit IIC COG3037 Cluster_345765 V1240530 map00030,map01100,map01110,map01120,map01230 G Transaldolase COG0176 Cluster_200899 V1240531 M Sortase family COG3764 Cluster_53785 V1240532 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_480398 V1240533 S MTH538 TIR-like domain (DUF1863) 11NXI Cluster_94699 V1240534 S NA 0XUTB Cluster_423412 V1240535 SP_1934 S NA 11SH4 Cluster_321414 V1240536 SP_1935 S Domain of unknown function (DUF955) 11KQS Cluster_151221 V1240537 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_56508 V1240538 LMRA V ABC transporter transmembrane region COG1132 Cluster_59590 V1240539 V ABC transporter, ATP-binding protein COG1132 Cluster_492174 V1240540 RMAH K Transcriptional regulator, MarR family 0XUB6 Cluster_128899 V1240541 THIC map00730,map01100 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) COG0422 Cluster_319936 V1240542 S Pfam:DUF124 COG2013 Cluster_140523 V1240543 S Membrane COG3949 Cluster_380595 V1240544 S Protein of unknown function (DUF541) 0YM36 Cluster_10803 V1240545 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_135883 V1240546 V DNA specificity domain protein COG0732 Cluster_88578 V1240547 HSDM V type I restriction-modification system COG0286 Cluster_98971 V1240548 UMUC L ImpB MucB SamB family protein COG0389 Cluster_637042 V1240549 S NA 0Y0CD Cluster_669894 V1240550 S NA 128RN Cluster_310749 V1240551 MANC map00051,map00520,map01100,map01110 M Mannose-1-phosphate guanylyltransferase COG0836 Cluster_138998 V1240553 S Inherit from NOG: Methyltransferase 0XSGP Cluster_365333 V1240554 DDPX M dipeptidase COG2173 Cluster_22279 V1240555 S NA 11FZK Cluster_265692 V1240558 S Membrane 11NPN Cluster_165346 V1240560 TYRA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydrogenase COG0287 Cluster_236108 V1240561 YLBL T Secreted protein COG3480 Cluster_1809 V1240562 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_60964 V1240563 S NA 11YT1 Cluster_84716 V1240564 RODA map00550,map04112 D cell cycle protein COG0772 Cluster_37493 V1240565 S Inherit from COG: leucine Rich Repeat COG4886 Cluster_55992 V1240572 S NA 0XQBQ Cluster_528900 V1240577 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_441009 V1240578 S NA 12BEE Cluster_294044 V1240579 L RecT family COG3723 Cluster_344147 V1240581 LIN1243 S domain protein COG1235 Cluster_306576 V1240582 L phage protein COG3935 Cluster_614247 V1240583 S VRR-NUC domain protein 0Z445 Cluster_543095 V1240584 S NA 11PZU Cluster_657197 V1240586 V HNH endonuclease 123A5 Cluster_621655 V1240587 S NA 0XWUM Cluster_68222 V1240588 BAS3806 L Terminase, large subunit COG4626 Cluster_159548 V1240589 S portal protein 11F33 Cluster_385911 V1240590 map04112 O ATP-dependent Clp protease, proteolytic subunit COG0740 Cluster_153663 V1240591 S phage major capsid protein (HK97 family) 128KE Cluster_669896 V1240594 S Phage head-tail adaptor 0XZH0 Cluster_596202 V1240595 S Prophage pi2 protein 37 11UE0 Cluster_674297 V1240596 S prophage pi2 protein 38 11U3I Cluster_429029 V1240597 S major tail protein, phi13 family 11ICY Cluster_534508 V1240598 S NA 11QC5 Cluster_17068 V1240600 S tail tape measure protein COG5280 Cluster_52827 V1240604 S Phage minor structural protein 0XPF3 Cluster_319937 V1240612 map02010 P cobalt transport COG0619 Cluster_37018 V1240613 map02010 P ABC transporter COG1122 Cluster_353747 V1240614 S NA 11WG4 Cluster_110059 V1240615 map04112 M Cell division protein FtsQ COG1589 Cluster_284 V1240618 FAS map00061,map01100 I fatty acid synthase COG4982 Cluster_44839 V1240619 ACCA map00061,map01100 I carboxylase COG4770 Cluster_29790 V1240620 S NA 11VT6 Cluster_728257 V1240621 S Protein of unknown function (DUF3343) 0XTWJ Cluster_133487 V1240622 E 2-hydroxyglutaryl-CoA dehydratase COG1775 Cluster_303687 V1240623 S NA 0Y843 Cluster_127499 V1240624 YIEG S Xanthine uracil vitamin C permease COG2252 Cluster_47869 V1240625 UUP S Abc transporter COG0488 Cluster_445000 V1240626 YFCE S Phosphodiesterase COG0622 Cluster_27584 V1240627 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_145725 V1240628 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_51740 V1240630 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_96817 V1240631 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_358778 V1240632 YEAZ O Peptidase M22 Glycoprotease COG1214 Cluster_502367 V1240633 YJEE S protein family UPF0079, ATPase COG0802 Cluster_138999 V1240634 APEB E M18 family aminopeptidase COG1362 Cluster_261685 V1240637 LYC M glycoside hydrolase, family 25 11T0J Cluster_165348 V1240638 S Inherit from NOG: domain protein 0XQTW Cluster_598 V1240641 M Putative peptidoglycan binding domain 100JY Cluster_212709 V1240642 ELI_1308 S tail protein 11P2A Cluster_108803 V1240644 YCEG F aminodeoxychorismate lyase COG1559 Cluster_10397 V1240645 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_373604 V1240646 S DNA-binding protein COG3943 Cluster_7060 V1240647 RV3193C S UPF0182 protein COG1615 Cluster_243896 V1240648 T Histidine kinase COG4585 Cluster_15042 V1240649 D domain protein 0XTIC Cluster_37176 V1240650 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_358779 V1240651 VICR map02020 T Two component transcriptional regulator, winged helix family COG0745 Cluster_56765 V1240652 VICK map02020 T Histidine kinase 0XNMH Cluster_290000 V1240655 S YycH protein 0ZZRJ Cluster_303688 V1240656 VICX map03013 S domain protein COG1235 Cluster_487329 V1240657 RLMH S Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) COG1576 Cluster_21491 V1240658 G domain protein 11V8D Cluster_174530 V1240660 map02010 P periplasmic COG3443 Cluster_371987 V1240661 map02010 P ABC transporter COG1121 Cluster_281724 V1240662 map02010 P ABC, transporter COG1108 Cluster_275085 V1240664 PDXS map00750 H Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) COG0214 Cluster_110060 V1240665 K Transcriptional regulator COG1167 Cluster_273729 V1240666 YITS S degv family COG1307 Cluster_370359 V1240667 LRGB map02020 M lrgb family COG1346 Cluster_576508 V1240668 LRGA map02020 S lrga family COG1380 Cluster_465171 V1240669 TPX O Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) COG2077 Cluster_618001 V1240670 SP_1144 K XRE family 11TZA Cluster_18504 V1240671 RES_1 V type IIi COG3421 Cluster_62379 V1240672 L adenine specific DNA methylase COG2189 Cluster_75169 V1240673 YJHA S Endonuclease Exonuclease phosphatase 0XNVA Cluster_14873 V1240674 XYLS map00052,map00500,map01100 G hydrolase, family 31 COG1501 Cluster_121397 V1240676 S Inherit from NOG: LPXTG-motif cell wall anchor domain protein 0YEBJ Cluster_144979 V1240677 M Cell wall binding repeat 2-containing protein COG2247 Cluster_43136 V1240680 YYBT T domain protein COG3887 Cluster_120626 V1240681 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_431014 V1240682 S Acetyltransferase GNAT Family 124QK Cluster_319938 V1240683 L Replication initiation and membrane attachment COG3935 Cluster_224348 V1240684 DNAC L DNA replication protein COG1484 Cluster_382365 V1240685 NNRE G Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity) COG0062 Cluster_551971 V1240686 S integral membrane protein 0ZXN5 Cluster_358780 V1240687 S radical SAM domain protein 11FK0 Cluster_138245 V1240690 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_172893 V1240691 M group 1 glycosyl transferase COG0438 Cluster_159549 V1240692 DACA map00550,map01100 M carboxypeptidase COG1686 Cluster_329109 V1240693 S DNA metabolism protein 11MJI Cluster_145726 V1240694 S radical SAM domain protein COG4277 Cluster_135070 V1240695 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_614248 V1240696 S Protein of unknown function (DUF1232) COG3339 Cluster_705431 V1240697 NATB C, P ABC transporter, permease COG1668 Cluster_49796 V1240698 M Cell wall anchor domain protein 11Q8J Cluster_13732 V1240700 SCLAV_1560 map02010 P ABC transporter COG1122 Cluster_436985 V1240701 WZB T protein tyrosine phosphatase COG0394 Cluster_512527 V1240702 RV2923C O OsmC family COG1765 Cluster_136694 V1240703 map00561,map01100 M group 1 glycosyl transferase COG0438 Cluster_284498 V1240704 S NA 11SYG Cluster_2777 V1240705 MT3296 L helicase COG0210 Cluster_678736 V1240706 L Integrase core domain protein COG2801 Cluster_724962 V1240707 S mobilization protein 11J0G Cluster_294045 V1240708 TMK map00240,map01100 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) COG0125 Cluster_152055 V1240710 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_135884 V1240711 DUSB J Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_44488 V1240712 S Inherit from NOG: Phage tail tape measure protein, tp901 family 0Y744 Cluster_523229 V1240713 S HTH_XRE 0Z7RT Cluster_233710 V1240714 S NA 120CJ Cluster_14570 V1240716 S NA 0Z4Z7 Cluster_199903 V1240717 map02010 S ABC-2 type transporter 11H02 Cluster_180336 V1240718 map02010 S ABC-2 type transporter 11HPT Cluster_375319 V1240719 S Protein of unknown function (DUF541) 0YM36 Cluster_560824 V1240720 SP_0256 K acetyltransferase, (GNAT) family COG0454 Cluster_176145 V1240722 ACD map00071,map00280,map00281,map00362,map00410,map00640,map00650,map01100,map01110,map01120,map03320 I Acyl-CoA dehydrogenase, C-terminal domain COG1960 Cluster_290001 V1240723 P phosphonate ABC transporter substrate-binding protein COG3221 Cluster_162894 V1240724 OCAR_7462 map00270,map00450,map01100,map01110,map01230 E Methionine synthase COG0620 Cluster_482718 V1240725 S OsmC-like protein 124NV Cluster_603285 V1240726 S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) COG0599 Cluster_497168 V1240727 GPO map00480,map00590 O Glutathione peroxidase COG0386 Cluster_130346 V1240728 S (LipO)protein 1C848@synNOG Cluster_78114 V1240729 map02010 G ABC transporter COG1129 Cluster_196161 V1240730 G ABC transporter integral membrane protein COG1172 Cluster_179509 V1240731 G abc transporter integral membrane protein COG1172 Cluster_133488 V1240732 BAS2305 G Major Facilitator superfamily COG0477 Cluster_407088 V1240733 S NA 11X7Q Cluster_316872 V1240734 FEPC map02010 P ABC, transporter COG1120 Cluster_207242 V1240735 FECD map02010 P Permease protein COG0609 Cluster_155299 V1240736 YVRC map02010 P Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) COG0614 Cluster_367041 V1240737 map02020 T response regulator 11ITI Cluster_131899 V1240738 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_58040 V1240739 map02010 S ABC transporter COG1123 Cluster_467257 V1240740 LUXS map00270,map05111 T Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) COG1854 Cluster_137484 V1240741 TATD L Hydrolase, tatD family COG0084 Cluster_29574 V1240743 RECG map03440 L ATP-dependent DNA helicase RecG COG1200 Cluster_90431 V1240745 S ABC superfamily, ATP binding cassette transporter COG4850 Cluster_35835 V1240748 S NA COG5412 Cluster_7955 V1240752 S domain protein 0XPXI Cluster_13547 V1240754 U, W Pfam:YadA COG5295 Cluster_130347 V1240755 LDTA S ErfK YbiS YcfS YnhG COG1376 Cluster_44099 V1240756 M Putative cell wall binding repeat 2 COG2247 Cluster_56766 V1240757 V Beta-lactamase COG1680 Cluster_13333 V1240758 FTSK D cell division protein FtsK COG1674 Cluster_515229 V1240759 S NA 0YSBG Cluster_34504 V1240760 S NA 11YT1 Cluster_2674 V1240761 P TonB-dependent Receptor Plug Domain protein COG4771 Cluster_130348 V1240762 RGPD map02010 P abc transporter COG1134 Cluster_24362 V1240763 LYTC M hydrolase, family 25 COG3757 Cluster_403604 V1240764 S NA 0ZTYV Cluster_76427 V1240766 PEPP E Xaa-Pro aminopeptidase COG0006 Cluster_447044 V1240767 S Signal transduction histidine kinase, lyts 11GMZ Cluster_183811 V1240768 M Cell wall binding repeat 2-containing protein COG2247 Cluster_452978 V1240769 S NA 11ZHA Cluster_683288 V1240770 YQGV S Domain of unknown function DUF77 COG0011 Cluster_269758 V1240771 DACF map00550,map01100 M carboxypeptidase COG1686 Cluster_163697 V1240772 P Sodium/hydrogen exchanger family COG0025 Cluster_546043 V1240773 S NA 0Y5YX Cluster_29446 V1240774 PFLB map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_273730 V1240776 YPFJ S zinc metallopeptidase COG2321 Cluster_392987 V1240777 S Phosphoribosyl transferase domain COG1040 Cluster_31188 V1240778 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_133489 V1240779 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_180337 V1240780 K Zinc finger helix-turn-helix protein, YgiT family 11YS4 Cluster_19749 V1240781 S NA 0YDZN Cluster_394811 V1240782 HSDS V type I restriction-modification system COG0732 Cluster_128189 V1240783 HSDS V restriction modification system DNA specificity domain COG0732 Cluster_147296 V1240784 PEPS E aminopeptidase COG2309 Cluster_141273 V1240787 S Inherit from COG: ATPase (AAA COG1373 Cluster_315345 V1240788 S B3 4 domain protein COG3382 Cluster_168540 V1240789 P Sodium/hydrogen exchanger family COG0025 Cluster_210487 V1240792 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_546044 V1240793 RIMI S ribosomal-protein-alanine acetyltransferase COG0456 Cluster_367042 V1240794 YEAZ O Peptidase M22 Glycoprotease COG1214 Cluster_546045 V1240795 YJEE S protein family UPF0079, ATPase COG0802 Cluster_221989 V1240796 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_15642 V1240797 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_241169 V1240798 PSTS2 map02010,map02020,map05152 P Phosphate-binding protein COG0226 Cluster_271064 V1240799 PSTC map02010 P phosphate abc transporter COG0573 Cluster_298197 V1240800 PSTA map02010 P phosphate abc transporter COG0581 Cluster_324561 V1240801 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_375320 V1240802 PHOU P Plays a role in the regulation of phosphate uptake COG0704 Cluster_367043 V1240803 PHOB map02020 T regulator COG0745 Cluster_219636 V1240804 S NA 10255 Cluster_239894 V1240806 S Membrane 0XQNE Cluster_146521 V1240808 P tonB-dependent Receptor COG4771 Cluster_272397 V1240810 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_2728 V1240811 MT3296 L helicase COG0210 Cluster_3391 V1240812 UVRD2 map03420,map03430 L helicase COG2887 Cluster_26370 V1240813 RECG map03440 L ATP-dependent DNA helicase RecG COG1200 Cluster_260372 V1240814 COBW S cobalamin synthesis protein COG0523 Cluster_309298 V1240815 DPEP_1223 S Uroporphyrinogen decarboxylase (URO-D) 11M62 Cluster_377085 V1240816 S corrinoid protein 11G0X Cluster_197908 V1240817 map00680,map00860,map01100,map01110,map01120 H Methyltransferase MtaA CmuA family COG0407 Cluster_78410 V1240818 DPEP_1224 C Ferredoxin COG3894 Cluster_512528 V1240819 S NA 0XWI3 Cluster_467258 V1240820 S Membrane 11G3C Cluster_335072 V1240821 YDJY S iron-sulfur cluster binding 100DI Cluster_186489 V1240822 YDJZ S SNARE associated Golgi protein-related protein COG0398 Cluster_130349 V1240823 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_234908 V1240824 SAGG map02010 V ABC transporter, ATP-binding protein COG1131 Cluster_183812 V1240825 map02010 S ABC-2 type transporter 11H02 Cluster_179510 V1240826 map02010 S ABC-2 type transporter 11HPT Cluster_138246 V1240827 GNTT2 E, G gntp family COG2610 Cluster_174532 V1240828 GLXK map00260,map00561,map00630,map01100,map01110 G Glycerate kinase COG1929 Cluster_188188 V1240829 K regulatoR COG3835 Cluster_275086 V1240830 YIHY S ribonuclease BN COG1295 Cluster_48077 V1240831 YUXL E Peptidase, S9A B C family, catalytic domain protein COG1506 Cluster_58041 V1240832 S NA 0XT1C Cluster_74819 V1240833 S NA 11YT1 Cluster_12458 V1240834 M Glycosyl transferase, family 2 0XPRU Cluster_644914 V1240835 XSEB map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) 121U6 Cluster_102805 V1240836 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_58797 V1240838 M Inherit from NOG: Lpxtg-motif cell wall anchor domain protein 0Y6CS Cluster_2857 V1240840 L DNA helicase COG1112 Cluster_31189 V1240841 CADA P heavy metal translocating p-type ATPase COG2217 Cluster_167688 V1240842 S NA 0YBPX Cluster_100019 V1240843 S Protein of unknown function (DUF3071) 102GP Cluster_121398 V1240844 MIAB J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) COG0621 Cluster_44100 V1240845 M Sulfatase COG1368 Cluster_9005 V1240846 S peptidase C10 11SDT Cluster_87269 V1240848 RPON map02020,map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG1508 Cluster_469384 V1240849 PURE map00230,map01100,map01110 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) COG0041 Cluster_398308 V1240850 YCGM map00350,map01100,map01120 Q fumarylacetoacetate (faa) hydrolase COG0179 Cluster_216150 V1240851 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_279080 V1240852 RPSB map03010 J 30S ribosomal protein S2 COG0052 Cluster_576509 V1240853 RPSI map03010 J 30S ribosomal protein S9 COG0103 Cluster_502368 V1240854 RPLM map03010 J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) COG0102 Cluster_41697 V1240855 P tonB-dependent Receptor 0XQNF Cluster_167689 V1240856 S Inherit from NOG: (LipO)protein 103B0 Cluster_143474 V1240857 S Cell surface protein 0XPAZ Cluster_63749 V1240858 S Pkd domain containing protein 101SU Cluster_168541 V1240859 S Cell surface protein 0XPAZ Cluster_19996 V1240860 S Pkd domain containing protein 101SU Cluster_321416 V1240861 ISPD map00900,map01100,map01110 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COG1211 Cluster_203979 V1240862 map00521,map00523,map01055,map01100,map01110 G, M epimerase dehydratase COG0451 Cluster_84717 V1240864 S NA 0YDPS Cluster_405420 V1240866 FKPB O peptidylprolyl cis-trans isomerase COG0545 Cluster_347354 V1240868 COBB map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_401829 V1240869 GPO map00480,map00590 O Glutathione peroxidase COG0386 Cluster_236109 V1240870 S Prolyl oligopeptidase family COG1073 Cluster_489678 V1240871 CDD map00240,map00983,map01100,map05219 F cytidine deaminase COG0295 Cluster_94700 V1240872 S NA 0XSGQ Cluster_242541 V1240873 map00051,map00500,map00520,map01100 G kinase (PfkB family COG0524 Cluster_156965 V1240874 NORV map05132 C domain protein COG0426 Cluster_174533 V1240875 S NA 0ZD9F Cluster_309299 V1240876 DAPB map00300,map01100,map01110,map01120,map01230 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) COG0289 Cluster_84718 V1240877 LEPB map03060 U Signal peptidase I COG0681 Cluster_403605 V1240879 AASI_0458 S WbqC-like 0ZW99 Cluster_56251 V1240880 P Na Pi-cotransporter COG1283 Cluster_30479 V1240881 YFMR S abc transporter COG0488 Cluster_50365 V1240882 SELB map00450,map00970 J Selenocysteine-specific translation elongation factor COG3276 Cluster_485043 V1240883 NUOE map00190,map00910,map01100 C NADH dehydrogenase (Ubiquinone), 24 kDa subunit COG1905 Cluster_50164 V1240884 HYMB map00190,map00910,map01100 C NADH dehydrogenase COG1894 Cluster_246495 V1240885 C NADH-ubiquinone oxidoreductase-G iron-sulfur binding region COG3383 Cluster_509959 V1240886 S Rubrerythrin 11P43 Cluster_181162 V1240887 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_4205 V1240888 YXCA I coA-substrate-specific enzyme activase COG3581 Cluster_233711 V1240889 LYTR K TRANSCRIPTIONal COG1316 Cluster_206144 V1240890 FNI map00900,map01100,map01110 C Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) COG1304 Cluster_73861 V1240891 SLGD_00064 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_336601 V1240892 map02010 P Cobalt transport protein COG0619 Cluster_363588 V1240893 L DNA alkylation repair enzyme COG4912 Cluster_34505 V1240894 S NA 11QZ9 Cluster_6295 V1240895 RECJ map03410,map03430,map03440 L Exonuclease RecJ COG0608 Cluster_592730 V1240897 GROS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) COG0234 Cluster_421552 V1240899 S Lema protein COG1704 Cluster_227779 V1240900 S Protein of unknown function (DUF3137) 11MSU Cluster_715058 V1240901 S NA 0ZFWW Cluster_526138 V1240902 AACA7 S Catalyzes the transfer of an acetyl group from acetyl- CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring (By similarity) 11UUS Cluster_373605 V1240903 LOLD V abc transporter atp-binding protein COG1136 Cluster_158698 V1240904 V abc transporter permease protein COG0577 Cluster_560825 V1240905 S NA 12ATY Cluster_256452 V1240906 K Transcriptional regulator, LysR family COG0583 Cluster_371988 V1240907 C SNARE associated Golgi COG0398 Cluster_101149 V1240908 PURB map00230,map00250,map01100,map01110 F Adenylosuccinate lyase COG0015 Cluster_2745 V1240909 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_88120 V1240910 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_118404 V1240911 PURF map00230,map00250,map01100,map01110 F glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_352084 V1240912 PURC map00230,map01100,map01110 F SAICAR synthetase COG0152 Cluster_60144 V1240914 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_35999 V1240915 YFMR S abc transporter COG0488 Cluster_131900 V1240917 V Mate efflux family protein COG0534 Cluster_218479 V1240918 SP_1419 map00970,map01100 J acetyltransferase, (GNAT) family COG1670 Cluster_284499 V1240919 GLPF G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) COG0580 Cluster_195310 V1240920 map00130,map01100,map01110 S methyltransferase, type 11 0XSKB Cluster_199904 V1240921 S filamentation induced by cAMP protein Fic COG3177 Cluster_64288 V1240922 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_39481 V1240923 S Exporters of the RND superfamily COG1033 Cluster_414405 V1240924 K Transcriptional regulator, TetR family 11IM0 Cluster_280380 V1240925 G Binding-protein-dependent transport system inner membrane component COG3833 Cluster_241170 V1240926 P binding-protein-dependent transport systems inner membrane component COG1175 Cluster_134281 V1240927 G ABC transporter substrate-binding protein 0XSJ0 Cluster_208365 V1240928 MSMX map02010 G (ABC) transporter COG3839 Cluster_2150 V1240930 MT3296 L helicase COG0210 Cluster_54300 V1240932 ILVB map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E acetolactate synthase COG0028 Cluster_485044 V1240934 S Uncharacterized protein conserved in bacteria (DUF2059) 122TA Cluster_499835 V1240935 RNHA map03030 S Ribonuclease COG3341 Cluster_167690 V1240936 THID H phosphomethylpyrimidine kinase COG2207 Cluster_193493 V1240937 PLPD S K07001 NTE family protein COG1752 Cluster_69614 V1240938 RLUA J Pseudouridine synthase COG0564 Cluster_129617 V1240939 YHAM S UPF0597 protein COG3681 Cluster_36000 V1240941 L Inherit from COG: Helicase COG1112 Cluster_412524 V1240942 map00730,map01100 H Thiamine monophosphate synthase 11FJG Cluster_313762 V1240943 H Involved in biosynthesis of the thiamine precursor thiazole (By similarity) COG1635 Cluster_72828 V1240944 THIC map00730,map01100 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) COG0422 Cluster_380597 V1240945 THIE map00730,map01100 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) COG0352 Cluster_294046 V1240946 THID map00730,map01100 H phosphomethylpyrimidine kinase COG0351 Cluster_347355 V1240947 FHUC map02010 P ABC transporter, ATP-binding protein COG1120 Cluster_303689 V1240948 O ADP-ribosylglycohydrolase COG1397 Cluster_12001 V1240949 SUSC P outer membrane protein SusC 0XNNV Cluster_139000 V1240953 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_16500 V1240954 PRIA map03440 L Primosomal protein n' COG1198 Cluster_233712 V1240955 S NA 0ZP8K Cluster_48962 V1240956 CADA P cadmium-exporting ATPase COG2217 Cluster_243897 V1240958 S YitT family COG1284 Cluster_63750 V1240959 PRC M Peptidase, S41 family COG0793 Cluster_463093 V1240960 S HutD COG3758 Cluster_55499 V1240961 FADD map00071,map01100,map03320,map04146,map04920 I Long-chain-fatty-acid--CoA ligase COG1022 Cluster_178636 V1240962 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_475802 V1240964 CYAA map00230,map04113 S Adenylate cyclase COG2954 Cluster_537399 V1240965 S NA 12AGZ Cluster_125416 V1240968 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_181163 V1240969 T response regulator COG2208 Cluster_135071 V1240970 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01230 G phosphohexose isomerase COG0166 Cluster_96818 V1240972 YJGR S ATP-binding protein COG0433 Cluster_348964 V1240973 Q methyltransferase, type 11 COG0500 Cluster_348965 V1240974 J methyltransferase COG0566 Cluster_353748 V1240975 GPH map00630,map01100,map01110 S HAD-superfamily hydrolase subfamily IA COG0546 Cluster_396587 V1240976 OCAR_6752 H DNA integration recombination invertion protein COG1636 Cluster_324562 V1240977 FDHD C Necessary for formate dehydrogenase activity (By similarity) COG1526 Cluster_387744 V1240978 P Formate nitrite transporter 11RP3 Cluster_160390 V1240979 MOEA H Molybdenum cofactor synthesis domain protein COG0303 Cluster_212710 V1240980 MOBA H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) COG0746 Cluster_252763 V1240981 E, G Membrane COG0697 Cluster_330508 V1240982 NPDA map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_563804 V1240983 S Zn-finger containing protein 121ND Cluster_164498 V1240984 O AhpC Tsa family 0ZVMV Cluster_549090 V1240985 C Binding Domain protein COG0348 Cluster_272398 V1240986 map00750,map01100 C Aldo Keto reductase COG0667 Cluster_596203 V1240987 K HTH_XRE 126GH Cluster_30586 V1240989 CADA P heavy metal translocating p-type ATPase COG2217 Cluster_373606 V1240991 UPP map00240,map01100 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) COG0035 Cluster_74492 V1240993 PCKA map00010,map00020,map00620,map00710,map01100,map01110,map01120 C Phosphoenolpyruvate Carboxylase COG1866 Cluster_355421 V1240994 S NA 11MD1 Cluster_327611 V1240995 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_443010 V1240996 OMPH M outer membrane chaperone Skp (OmpH) 11GII Cluster_471542 V1240997 OMPH M Membrane 11TPU Cluster_281725 V1240998 MURI map00471,map01100 M Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) COG0796 Cluster_427136 V1240999 SPOU map00340,map00350,map00624,map01120 J tRNA rRNA methyltransferase (SpoU) COG0566 Cluster_546046 V1241000 SUFE S Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) COG2166 Cluster_499836 V1241001 S doxx family 124YF Cluster_238621 V1241003 NADC map00760,map01100 H nicotinate-nucleotide pyrophosphorylase COG0157 Cluster_30715 V1241004 S NA 11QZ9 Cluster_473647 V1241005 RPLQ map03010 J 50S ribosomal protein l17 COG0203 Cluster_216151 V1241006 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_403606 V1241007 RPSD map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) COG0522 Cluster_573281 V1241008 RPSK map03010 J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) COG0100 Cluster_781206 V1241009 INFA J however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) COG0361 Cluster_300857 V1241010 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_119898 V1241011 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_517902 V1241012 RPLO map03010 J Binds to the 23S rRNA (By similarity) COG0200 Cluster_836247 V1241013 RPMD map03010 J 50S ribosomal protein L30 1036C Cluster_465172 V1241014 RPSE map03010 J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) COG0098 Cluster_625450 V1241015 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_429030 V1241016 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_566995 V1241017 RPSH map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) COG0096 Cluster_683290 V1241018 RPSN map03010 J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) COG0199 Cluster_436986 V1241019 RPLE map03010 J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COG0094 Cluster_661409 V1241020 RPLX map03010 J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) COG0198 Cluster_599715 V1241021 RPLN map03010 J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) COG0093 Cluster_724963 V1241022 RPSQ map03010 J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal COG0186 Cluster_813244 V1241023 RPMC map03010 J 50S ribosomal protein L29 1226R Cluster_534509 V1241024 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_333568 V1241025 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_551972 V1241026 RPLV map03010 J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) COG0091 Cluster_288712 V1241027 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_189896 V1241028 S ApbE family 11H27 Cluster_36145 V1241029 BL01323 M Cell wall binding repeat 2-containing protein 0ZKZU Cluster_53283 V1241030 map02010 V ABC transporter 0XPIZ Cluster_353749 V1241031 T response regulator COG3279 Cluster_272399 V1241032 GALU map00040,map00052,map00500,map00520,map01100,map01110 M UTP-glucose-1-phosphate uridylyltransferase COG1210 Cluster_19922 V1241033 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_441010 V1241034 ELI_3039 K RNA Polymerase 1261F Cluster_21225 V1241035 CYDC map02010 V abc transporter COG4988 Cluster_64024 V1241036 YFCC S c4-dicarboxylate anaerobic carrier COG1288 Cluster_79 V1241037 M domain protein COG4932 Cluster_104607 V1241044 LPDA map00010,map00020,map00260,map00280,map00620,map01100,map01110,map01120 C dihydrolipoyl dehydrogenase COG1249 Cluster_154463 V1241045 HTRA map03010 M peptidase S1 and S6, chymotrypsin Hap COG0265 Cluster_104007 V1241046 SUFB O FeS assembly protein SUFB COG0719 Cluster_142000 V1241047 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_678738 V1241048 DIND S DNA-damage-inducible protein d 0XQQP Cluster_189030 V1241049 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_37328 V1241050 S SusD family 0XPTK Cluster_28355 V1241051 M Cell wall anchor domain protein 11Q8J Cluster_687718 V1241052 map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120 C oxidoreductase, delta subunit COG1144 Cluster_171979 V1241053 PORA map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG0674 Cluster_259067 V1241054 map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120 C oxidoreductase, beta subunit COG1013 Cluster_116298 V1241055 map00360,map00642,map01120,map01220 Q AMP-binding enzyme COG1541 Cluster_165349 V1241056 YBDL map00300,map01100,map01120,map01230 E Aminotransferase COG0436 Cluster_103434 V1241057 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_141274 V1241058 S UPF0597 protein COG3681 Cluster_473648 V1241059 MUG map03410 L U mismatch-specific DNA glycosylase COG3663 Cluster_299477 V1241060 THID map00730,map00750,map01100 H phosphomethylpyrimidine kinase COG0351 Cluster_94701 V1241061 MALQ map00500,map01100 G 4-alpha-glucanotransferase (EC 2.4.1.25) COG1640 Cluster_284500 V1241062 S Membrane 11NPN Cluster_17013 V1241064 MALQ map00500,map01100,map01110 G 4-alpha-glucanotransferase COG1640 Cluster_124103 V1241066 G Major Facilitator COG0477 Cluster_206145 V1241067 K Transcriptional regulator, LacI family COG1609 Cluster_74186 V1241068 S ragb susd domaiN-containing protein 0XP53 Cluster_41520 V1241069 AMYA2 map00500,map01100,map04973 G Alpha-amylase COG0366 Cluster_482719 V1241071 FOLA map00670,map00790,map01100 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) COG0262 Cluster_197909 V1241073 CORA P magnesium and cobalt transport protein CorA COG0598 Cluster_25902 V1241075 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_196980 V1241076 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_114218 V1241077 MURF map00300,map00550,map01100 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) COG0770 Cluster_360446 V1241078 YDJZ S SNARE associated Golgi protein-related protein COG0398 Cluster_138247 V1241079 GLTP C Transporter, dicarboxylate amino acid cation Na H symporter family protein COG1301 Cluster_60655 V1241080 SP_1634 S Protein of unknown function (DUF2974) 0XSVF Cluster_358781 V1241081 RDGB map00230,map00240,map01100 F Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) COG0127 Cluster_58545 V1241083 E Extracellular solute-binding protein, family 5 COG0747 Cluster_72829 V1241084 GSIA map02010 S ABC transporter COG1123 Cluster_586 V1241086 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_252764 V1241087 C radical SAM domain protein COG1032 Cluster_336602 V1241088 BIRA map00780,map01100 H biotin acetyl-CoA-carboxylase ligase COG0340 Cluster_711674 V1241089 YAFQ S addiction module toxin, RelE StbE family COG3041 Cluster_734770 V1241090 S SpoVT_AbrB 121AX Cluster_401830 V1241091 L Transposase 11M0T Cluster_11403 V1241092 SP_0498 G endo-beta-N-acetylglucosaminidase COG4724 Cluster_480399 V1241093 S NA 0Y615 Cluster_509960 V1241094 S NA 0ZYA7 Cluster_480400 V1241095 COAD map00770,map01100 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) COG0669 Cluster_546047 V1241096 YBEY S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) COG0319 Cluster_69940 V1241097 CTPA M Peptidase, S41 family COG0793 Cluster_45571 V1241098 PARE L Dna topoisomerase iv (Subunit b) COG0187 Cluster_157830 V1241099 S NA 0XRNH Cluster_306577 V1241100 DDPX M dipeptidase COG2173 Cluster_290002 V1241101 XYNB I esterase COG0657 Cluster_458917 V1241102 map00230 S mutt nudix family protein 11RXE Cluster_136695 V1241103 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_192609 V1241104 RLUD J Pseudouridine synthase COG0564 Cluster_152893 V1241105 MSCS M Mechanosensitive ion channel COG0668 Cluster_6204 V1241108 S NA 12BGB Cluster_48540 V1241109 S NA 102WG Cluster_110062 V1241110 LYTR2 K TRANSCRIPTIONal COG1316 Cluster_220825 V1241111 LDH map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120 C L-Lactate dehydrogenase COG0039 Cluster_87270 V1241112 LIPL48 S (LipO)protein 0XQ4U Cluster_193494 V1241113 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG2852 Cluster_45000 V1241114 LYTC M hydrolase, family 25 COG3757 Cluster_23493 V1241115 M Glycosyl transferase, family 2 0ZNJT Cluster_267006 V1241117 ALKA map03410 L 8-oxoguanine DNA glycosylase COG0122 Cluster_391174 V1241118 REX K Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) COG2344 Cluster_336603 V1241119 SRTB U sortase, SrtB family COG4509 Cluster_92365 V1241120 POTE5 E amino acid COG0531 Cluster_255225 V1241122 S amidinotransferase COG4874 Cluster_288713 V1241123 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_257742 V1241124 I Diacylglycerol kinase COG1597 Cluster_333569 V1241125 FABG map00061,map00780,map01040,map01100 S reductase 0XNW1 Cluster_144226 V1241126 DCTP C symporter COG1301 Cluster_264363 V1241127 SDAAA map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase COG1760 Cluster_368656 V1241128 SDAAB map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase, iron-sulfur-dependent, beta subunit COG1760 Cluster_78411 V1241129 H Transporter COG2978 Cluster_335073 V1241130 S radical SAM domain protein 11FK0 Cluster_175346 V1241131 T ATPase histidine kinase DNA gyrase B HSP90 domain protein 11IP0 Cluster_220826 V1241133 LDH map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120 C L-Lactate dehydrogenase COG0039 Cluster_97888 V1241135 SUFB O FeS assembly protein SUFB COG0719 Cluster_322977 V1241137 SUFC O feS assembly ATPase SufC COG0396 Cluster_119134 V1241138 SUFD O feS assembly protein SufD COG0719 Cluster_144980 V1241139 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_407089 V1241141 RNHB map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0164 Cluster_231283 V1241142 S HTH domain protein 11Z0Z Cluster_12254 V1241144 RAGA P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_84288 V1241145 RAGB S RagB SusD domain protein 0XZ44 Cluster_63751 V1241146 S NA 0ZTN9 Cluster_177800 V1241147 M chain length determinant protein 0Y1H4 Cluster_255226 V1241148 S NA 11XPJ Cluster_198904 V1241150 M Sortase family COG3764 Cluster_344148 V1241152 AMD E amidohydrolase COG1473 Cluster_15571 V1241153 S NA 12BGB Cluster_10490 V1241154 O cysteine protease COG4870 Cluster_78115 V1241155 GLNP E Abc transporter COG0834 Cluster_333570 V1241156 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_302235 V1241157 ECFT map02010 P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) COG0619 Cluster_273731 V1241158 ECFA2 map02010 P Abc transporter COG1122 Cluster_284501 V1241159 ECFA1 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_18047 V1241160 CTPE P ATPase, P-type (Transporting), HAD superfamily, subfamily IC COG0474 Cluster_7300 V1241161 S NA 12BGB Cluster_78787 V1241162 FTSE map02010 D Cell division ATP-binding protein ftsE COG2884 Cluster_35047 V1241163 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_252765 V1241164 S NA 125RT Cluster_236110 V1241165 RSGA G May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) COG1162 Cluster_203980 V1241166 MUTY map03410 L a g-specific adenine glycosylase COG1194 Cluster_421553 V1241167 CHBA map02060 G PTS System COG1447 Cluster_27781 V1241168 S NA 0XT1C Cluster_166161 V1241169 ADH map00051,map00363,map00591,map00625,map00650,map01100,map01120 C iron-containing alcohol dehydrogenase COG1454 Cluster_352085 V1241170 CPAP_0279 L Transposase COG2801 Cluster_447045 V1241171 L Transposase 11X46 Cluster_114887 V1241172 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_24470 V1241173 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_217344 V1241174 MCSB map00330 E ATP guanido phosphotransferase COG3869 Cluster_408862 V1241175 K NA 0ZR1Z Cluster_896406 V1241178 HSDR V Type I Restriction COG0610 Cluster_4014 V1241181 S S-layer domain protein 12C8X Cluster_197910 V1241182 SUA J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0009 Cluster_528901 V1241183 RPIB map00030,map00052,map00710,map01100,map01110,map01120,map01230 G isomerase COG0698 Cluster_394812 V1241184 UPP map00240,map01100 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) COG0035 Cluster_206146 V1241185 TAGO M Glycosyl transferase, family 4 COG0472 Cluster_181164 V1241186 WECB map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_183813 V1241187 YCHF J gtp-binding protein COG0012 Cluster_243898 V1241188 L DNA polymerase COG3359 Cluster_762367 V1241189 O Glutaredoxin 125U3 Cluster_100567 V1241190 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_8850 V1241191 S Inherit from NOG: Tail protein 11MY0 Cluster_382366 V1241192 S Bacteriophage Gp15 protein 11NHP Cluster_570079 V1241196 S Pfam:Minor_capsid 0Z6Z7 Cluster_268420 V1241201 LGAS_0610 S Major capsid protein 11IJY Cluster_429031 V1241202 S NA 0YY7U Cluster_741537 V1241203 S NA 0XWKC Cluster_741538 V1241204 S NA 0XW6Y Cluster_72830 V1241206 S Minor capsid protein 0Y58E Cluster_87693 V1241207 S minor capsid protein 0XSIM Cluster_7623 V1241209 HSDR V Type I Restriction COG0610 Cluster_363589 V1241210 ISCU C SUF system FeS assembly protein COG0822 Cluster_116299 V1241211 SUFD O feS assembly protein SufD COG0719 Cluster_288714 V1241213 GLPR K Transcriptional regulator COG1349 Cluster_47115 V1241214 S L,D-transpeptidase catalytic domain COG1376 Cluster_82547 V1241215 GLYQS map00970 J Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) COG0423 Cluster_15777 V1241216 PARC L DNA topoisomerase IV, subunit A COG0188 Cluster_269759 V1241217 S Protein of unknown function (DUF3316) 11MGD Cluster_206147 V1241218 M peptidase, S41 COG0793 Cluster_135885 V1241219 S The GLUG motif protein family protein 11ZVU Cluster_37329 V1241220 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_17812 V1241221 CTPE P ATPase, P-type (Transporting), HAD superfamily, subfamily IC COG0474 Cluster_401831 V1241223 V ABC, transporter COG1136 Cluster_350587 V1241224 YBBM S ABC transporter, permease COG0390 Cluster_115573 V1241225 FUMC map00020,map00720,map01100,map01110,map01120,map05200,map05211 C fumarate hydratase class II COG0114 Cluster_492175 V1241227 BMUL_3003 S Membrane COG3619 Cluster_173719 V1241228 map00270,map01100,map04122 P sulfurtransferase COG2897 Cluster_219637 V1241233 PHYA S Phospholipid glycerol acyltransferase COG3176 Cluster_294047 V1241234 ENC_23920 S Phospholipid glycerol acyltransferase COG3176 Cluster_447046 V1241235 MRAZ S mraZ protein COG2001 Cluster_232448 V1241236 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_368657 V1241237 S NA 1265D Cluster_34506 V1241238 FTSI map00550 M penicillin-binding protein COG0768 Cluster_89064 V1241239 MURE map00300,map00550,map01100 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_136696 V1241240 MRAY map00550,map01100 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) COG0472 Cluster_122162 V1241241 MURD map00471,map00550,map01100 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COG0771 Cluster_138248 V1241242 FTSW map04112 D cell cycle protein, FtsW RodA SpoVE family COG0772 Cluster_15043 V1241243 ATP2C1 P p-type ATPase COG0474 Cluster_306578 V1241244 S Metal dependent hydrolase COG2220 Cluster_497169 V1241245 YBAK S YbaK ebsC protein COG2606 Cluster_128190 V1241246 GSHA map00480,map01100 H glutamate--cysteine ligase COG3572 Cluster_126806 V1241247 S NA 0XPEA Cluster_721615 V1241248 S addiction module toxin, Txe YoeB family COG4115 Cluster_744837 V1241249 D prevent-host-death family COG2161 Cluster_247752 V1241250 M hydrolase, family 25 COG3757 Cluster_74493 V1241251 S DivIVA domain repeat protein 11XZ2 Cluster_55500 V1241252 SUDEN_0690 S NA 11Z35 Cluster_7301 V1241253 V restriction COG1002 Cluster_777455 V1241254 S helix-turn-helix domain protein 122WR Cluster_546048 V1241255 S NA 0YIEB Cluster_130350 V1241256 L Integrase 0YTFQ Cluster_294048 V1241258 METN map02010 P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COG1135 Cluster_121399 V1241260 U relaxase mobilization nuclease domain protein COG3843 Cluster_59348 V1241264 L Recombinase COG1961 Cluster_77821 V1241265 map02010 V (ABC) transporter COG1132 Cluster_139001 V1241266 S Membrane 0XPGQ Cluster_230109 V1241267 LPLA map00785,map01100 H Lipoate-protein ligase COG0095 Cluster_504774 V1241269 YBBK J Purine nucleoside phosphorylase COG1683 Cluster_385912 V1241270 MAF D MAF-like protein COG0424 Cluster_251543 V1241271 LACC map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G tagatose-6-phosphate kinase COG1105 Cluster_50765 V1241272 FRUA map00051,map01100,map02060 G PTS System COG1445 Cluster_13042 V1241273 V Type III restriction enzyme, res subunit 0ZVHQ Cluster_441011 V1241274 YFCE S Phosphodiesterase COG0622 Cluster_176146 V1241275 DPRA L DNA protecting protein DprA COG0758 Cluster_551973 V1241276 S Thioesterase 11QVX Cluster_131133 V1241277 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_231284 V1241278 S NA 11VJW Cluster_327612 V1241279 HEMD map00860,map01100,map01110 H uroporphyrinogeN-iii synthase 0XVP9 Cluster_537400 V1241280 RNPA J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) 122NB Cluster_129619 V1241281 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_291310 V1241283 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_162057 V1241284 S domain protein 11ZQG Cluster_543097 V1241286 S small multi-drug export COG2426 Cluster_378867 V1241287 H IA, variant 3 COG0637 Cluster_61277 V1241288 CYDD map02010 V ABC, transporter COG4988 Cluster_69615 V1241289 CYDC map02010 V Abc transporter COG1132 Cluster_676 V1241290 U, W Pfam:HIM COG5295 Cluster_463094 V1241291 S Inherit from COG: ATPase (AAA COG1373 Cluster_348966 V1241292 ADCC map02010 P ABC transporter COG1121 Cluster_36001 V1241294 GLFT M Transferase COG1216 Cluster_209411 V1241295 YICL E, G Transporter COG0697 Cluster_231285 V1241296 S NA 12D91 Cluster_4240 V1241297 UVRD2 map03420,map03430 L helicase COG0210 Cluster_363590 V1241299 L DNA alkylation repair enzyme COG4912 Cluster_489679 V1241300 S Resistance protein COG3467 Cluster_465173 V1241302 C Nitroreductase COG0778 Cluster_443011 V1241303 BL01877 K Transcriptional regulator COG1309 Cluster_350588 V1241304 BDP_1102 V ABC transporter COG1136 Cluster_9094 V1241305 YLBB V abc transporter permease protein COG0577 Cluster_306579 V1241306 S NA 1249W Cluster_563807 V1241307 S HIRAN domain 0XVUM Cluster_341038 V1241308 E Peptidase family S51 11R1E Cluster_352086 V1241309 SP_1668 S TIGR02206 family 11T9J Cluster_528903 V1241310 ELAA S gCN5-related N-acetyltransferase COG2153 Cluster_16378 V1241311 FNI map00900,map01100,map01110 C Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) COG1577 Cluster_96819 V1241312 MVAD map00900,map01100,map01110 I diphosphomevalonate decarboxylase COG3407 Cluster_166887 V1241314 NIFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_208366 V1241315 SELU S Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) COG2603 Cluster_335074 V1241317 S TraX protein 11N9P Cluster_117719 V1241318 NOX map00190 P pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_38138 V1241319 YHGE S domain protein COG1511 Cluster_261686 V1241320 S Protein of unknown function (Porph_ging) 124PH Cluster_252766 V1241321 S Protein of unknown function (Porph_ging) 124PH Cluster_237306 V1241322 RSGA G May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) COG1162 Cluster_433009 V1241323 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_494661 V1241324 YEBR T gaf domain protein COG1956 Cluster_298198 V1241325 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_208367 V1241326 S membrane 0Z8C3 Cluster_96299 V1241327 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_245174 V1241328 CORA P transporter COG0598 Cluster_87694 V1241329 S tonB-dependent receptor plug 0ZJPA Cluster_300858 V1241330 RRMJ J Hemolysin A COG1189 Cluster_272400 V1241331 ISPA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_96820 V1241333 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_563808 V1241334 NUSB K Involved in the transcription termination process (By similarity) COG0781 Cluster_576511 V1241335 ASP S alkaline shock protein COG1302 Cluster_335075 V1241336 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_302236 V1241337 ECFT map02010 P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) COG0619 Cluster_271065 V1241338 ECFA2 map02010 P Abc transporter COG1122 Cluster_288715 V1241339 ECFA1 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_398309 V1241340 MAG map03410 L 3-methyladenine DNA glycosylase COG2094 Cluster_582862 V1241341 S Protein of unknown function (DUF1232) 1221F Cluster_391175 V1241342 PYRE map00240,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_348967 V1241343 PYRF map00240,map01100 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) COG0284 Cluster_178637 V1241344 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_267007 V1241348 PDXS map00750 H Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) COG0214 Cluster_416176 V1241349 PDXT map00750 H Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) COG0311 Cluster_145727 V1241350 S domain protein 12672 Cluster_148826 V1241352 L Integrase COG4974 Cluster_211620 V1241354 S RES 17BRN@proNOG Cluster_15643 V1241355 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_21407 V1241356 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_200900 V1241357 NRDB map00230,map00240,map00480,map01100,map04115 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_52364 V1241358 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_42217 V1241359 ABPB map00310,map00780,map01100 E Dipeptidase COG4690 Cluster_239895 V1241360 MSRA O reductase COG0229 Cluster_242542 V1241361 GLSA map00250,map00330,map00471,map00910,map01100,map01120,map04724,map04727,map04964 E Glutaminase COG2066 Cluster_105813 V1241362 AGCS E amino acid carrier protein COG1115 Cluster_213830 V1241363 J Ribonuclease COG1530 Cluster_8747 V1241365 PBP2B map00550,map01100 M penicillin-binding protein COG0768 Cluster_276418 V1241366 MREC M Involved in formation and maintenance of cell shape (By similarity) COG1792 Cluster_367044 V1241367 RADC L DNA repair protein (RadC COG2003 Cluster_220827 V1241368 SP_0859 S Membrane COG3817 Cluster_365335 V1241369 ENC_10390 S Membrane COG3819 Cluster_108189 V1241371 K Transcriptional regulator GntR family COG1167 Cluster_777457 V1241372 S toxin-antitoxin system, antitoxin component, ribbon-helix-helix 121PE Cluster_131901 V1241373 S modulator of DNA gyrase family protein COG0312 Cluster_128900 V1241374 VMRA V Mate efflux family protein COG0534 Cluster_53515 V1241375 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_43492 V1241376 ACTP P Copper-exporting ATPase COG2217 Cluster_307885 V1241377 SIGB K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG1191 Cluster_669898 V1241379 RSBV T stage II sporulation protein COG1366 Cluster_24186 V1241380 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_47870 V1241381 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_288716 V1241382 S haloacid dehalogenase-like hydrolase COG0561 Cluster_12631 V1241383 LYSX map00970,map05150 J Membrane COG2898 Cluster_456936 V1241384 APT map00230,map01100 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) COG0503 Cluster_97361 V1241385 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_27185 V1241386 COPA P p-type ATPase COG2217 Cluster_805215 V1241387 COPZ map04978 P Heavy-metal-associated domain 0XUQ1 Cluster_728259 V1241388 S Copper-sensing transcriptional repressor CsoR COG1937 Cluster_447047 V1241389 RAIA J ribosomal subunit Interface protein COG1544 Cluster_348968 V1241390 DEOD map00230,map00240,map00270,map00760,map01100,map01110 F purine nucleoside phosphorylase DeoD-type COG0813 Cluster_378868 V1241391 DEOC map00030 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) COG0274 Cluster_305192 V1241392 HISK map00340,map01100,map01110,map01230 E histidinol phosphate phosphatase hisj family COG1387 Cluster_238622 V1241393 GYAR map00260,map00630,map00680,map01100,map01120,map01230 C 2-hydroxyacid dehydrogenase COG1052 Cluster_131134 V1241394 WBLL S NA 0XWNY Cluster_208368 V1241395 CPS4C M biosynthesis protein COG3944 Cluster_127500 V1241396 P integral membrane protein COG1253 Cluster_51924 V1241397 BOPA E Extracellular solute-binding protein, family 5 COG0747 Cluster_27464 V1241398 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_218480 V1241399 RLMB map00340,map00350,map00624,map01120 J RNA methyltransferase TrmH family group 3 COG0566 Cluster_327613 V1241400 S Pfam:DUF901 11XWA Cluster_14685 V1241401 M domain protein 0ZWTG Cluster_330509 V1241402 map00633,map01120 C nitroreductase COG0778 Cluster_19450 V1241403 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_543098 V1241404 FOLB map00790,map01100 H dihydroneopterin aldolase COG1539 Cluster_143475 V1241405 AMIA M n-acetylmuramoyl-l-alanine amidase COG0860 Cluster_223163 V1241406 S Mammalian cell entry related domain protein 0YWNZ Cluster_105198 V1241407 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_350589 V1241408 THIN map00730,map01100 H thiamine COG1564 Cluster_410716 V1241409 PNUC H Nicotinamide Mononucleotide Transporter COG3201 Cluster_46728 V1241411 DXS map00730,map00900,map01100,map01110 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) COG1154 Cluster_58798 V1241412 PEPP E peptidase, M24 COG0006 Cluster_54033 V1241413 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_467260 V1241414 THIW S thiw protein COG4732 Cluster_298199 V1241415 THIM map00730,map01100 H 4-methyl-5-beta-hydroxyethylthiazole kinase COG2145 Cluster_382367 V1241416 THIE map00730,map01100 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) COG0352 Cluster_606922 V1241417 S NA 0Y3IW Cluster_122163 V1241418 S NA 11GQ4 Cluster_70893 V1241420 M Putative cell wall binding repeat 2 COG2247 Cluster_45001 V1241421 map02010 P ABC transporter COG1122 Cluster_33245 V1241422 S von Willebrand factor, type A COG2304 Cluster_380598 V1241423 ADK map00230,map00240,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_705434 V1241424 S (ribosomal) protein 0ZY3U Cluster_781208 V1241425 INFA J however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) COG0361 Cluster_614249 V1241426 RPSM map03010 J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits COG0099 Cluster_563809 V1241427 RPSK map03010 J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) COG0100 Cluster_233713 V1241428 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_629147 V1241429 RPLQ map03010 J 50S ribosomal protein l17 COG0203 Cluster_463095 V1241430 S HutD COG3758 Cluster_167691 V1241432 BMUL_2900 map00340,map00350,map00624,map01120 Q methyltransferase COG0500 Cluster_159550 V1241433 CZCD P cation diffusion facilitator family transporter COG0053 Cluster_148827 V1241434 GSHA map00480,map01100 H glutamate--cysteine ligase COG3572 Cluster_436988 V1241435 FOLA map00670,map00790,map01100 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) COG0262 Cluster_84289 V1241436 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_76428 V1241437 YBIT S ABC transporter, ATP-binding protein COG0488 Cluster_175347 V1241438 map00860,map01100,map01110 H Uroporphyrinogen decarboxylase COG0407 Cluster_206148 V1241439 PURM map00230,map01100,map01110 F phosphoribosylaminoimidazole synthetase COG0150 Cluster_233714 V1241440 LACC map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G tagatose-6-phosphate kinase COG1105 Cluster_69265 V1241441 map02010 E ABC, transporter COG4166 Cluster_249070 V1241442 OPPC map02010 P ABC transporter (Permease COG1173 Cluster_162058 V1241443 OPPF map02010 E (ABC) transporter COG4608 Cluster_382368 V1241444 NT5E map00230,map00240,map00630,map00760,map01100,map01110 S Hydrolase COG0546 Cluster_279081 V1241445 AADK S Aminoglycoside 6-adenylyltransferase 0YSKJ Cluster_592731 V1241446 S NA 0XWZA Cluster_215013 V1241447 AROF map00400,map01100,map01110,map01230 E phospho-2-dehydro-3-deoxyheptonate aldolase COG2876 Cluster_203981 V1241448 AROB map00230,map00400,map01100,map01110,map01230 E 3-dehydroquinate synthase COG0337 Cluster_362021 V1241449 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_145728 V1241450 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_33121 V1241451 RECQ map03018 L ATP-dependent DNA helicase RecQ COG0514 Cluster_91385 V1241452 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_101150 V1241453 O Peptidyl-prolyl cis-trans isomerase COG0760 Cluster_100020 V1241454 O peptidylprolyl cis-trans isomerase COG0760 Cluster_46526 V1241455 S osta family 0XUST Cluster_32855 V1241456 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_47495 V1241457 MALL map00052,map00500,map01100 G trehalose-6-phosphate hydrolase (EC 3.2.1.93) COG0366 Cluster_312268 V1241458 SCLAV_5050 map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_218481 V1241461 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_273732 V1241462 S CAAX amino terminal protease family protein COG1266 Cluster_133490 V1241463 MTAD F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) COG0402 Cluster_380599 V1241466 YADS S Membrane COG2860 Cluster_669899 V1241467 YQGV S Domain of unknown function DUF77 COG0011 Cluster_230110 V1241468 DMPA E, Q peptidase s58 dmpa COG3191 Cluster_305193 V1241469 SP_1232 S Membrane COG4684 Cluster_309300 V1241470 K Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) COG1521 Cluster_288717 V1241471 MURI map00230,map00240,map00471,map01100 M Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) COG0796 Cluster_378869 V1241472 T cyclic nucleotide-binding domain protein COG0664 Cluster_332066 V1241476 S iron-sulfur cluster binding 100DI Cluster_241171 V1241479 YHCC S Radical SAM Protein COG1242 Cluster_284502 V1241480 COF S hydrolase COG0561 Cluster_653068 V1241481 S Protein of unknown function (DUF1292) 0ZYX4 Cluster_108190 V1241482 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_177801 V1241483 S NA 11JEI Cluster_219638 V1241484 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_16271 V1241486 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_99494 V1241487 S NA 0XWFB Cluster_296800 V1241488 Q DSBA-like thioredoxin domain COG2761 Cluster_285949 V1241489 PANC map00410,map00770,map01100,map01110 H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) COG0414 Cluster_275087 V1241490 YOCS S Bile acid COG0385 Cluster_502369 V1241491 NIMB S Resistance protein COG3467 Cluster_678740 V1241492 S Cupin domain 0ZNGI Cluster_367045 V1241493 S NA 0ZM2A Cluster_28156 V1241494 GLTA map00250,map00910,map01100,map01110,map01120,map01230 E Glutamate synthase COG0543 Cluster_309301 V1241495 PROB map00330,map01100,map01230 E Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) COG0263 Cluster_140524 V1241496 PROA map00330,map01100,map01230 E Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) COG0014 Cluster_540197 V1241497 map00790,map01100 H synthase COG0720 Cluster_40388 V1241498 S domain protein 0YF83 Cluster_46527 V1241499 DXS map00730,map00900,map01100,map01110 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) COG1154 Cluster_119899 V1241500 TRKA P Potassium uptake protein COG0569 Cluster_95712 V1241501 TRKH P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) COG0168 Cluster_203982 V1241502 S abc transporter atp-binding protein 11J2E Cluster_255227 V1241503 S abc transporter atp-binding protein 11J2E Cluster_396588 V1241504 S NA 1204F Cluster_144981 V1241505 LYS1 map00300,map00310,map01100,map01110,map01230 E saccharopine dehydrogenase COG1748 Cluster_657198 V1241506 K TfoX domain protein COG3070 Cluster_871937 V1241507 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_1474 V1241511 G Aamy_C COG1523 Cluster_332067 V1241512 ISCU C SUF system FeS assembly protein COG0822 Cluster_43323 V1241513 S TPR repeat-containing protein COG0457 Cluster_280381 V1241521 S CAAX amino terminal protease family protein COG1266 Cluster_629148 V1241522 YPJD S MazG nucleotide pyrophosphohydrolase COG1694 Cluster_512529 V1241524 DTD J Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) COG1490 Cluster_52594 V1241525 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_452979 V1241526 APT map00230,map01100 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) COG0503 Cluster_50766 V1241527 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_357107 V1241528 SDHC map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120 C cytochrome b subunit 0YBKA Cluster_43493 V1241529 SDHA map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020,map05134 C succinate dehydrogenase, flavoprotein subunit COG1053 Cluster_227780 V1241530 HTRB map00540,map01100 M Lipid A Biosynthesis COG1560 Cluster_249071 V1241531 map00051 M Glycosyl transferase, family 2 COG1216 Cluster_312269 V1241532 S NA 11R06 Cluster_160393 V1241533 M Glycosyl transferase (Group 1 1788Y@proNOG Cluster_267008 V1241534 LPSA S lipopolysaccharide core biosynthesis protein 0ZUPW Cluster_288718 V1241535 S NA 0ZJBA Cluster_18762 V1241538 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_403607 V1241539 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_384135 V1241540 M lytic transglycosylase COG0741 Cluster_55755 V1241541 BGAC map00052,map00511,map00600,map01100 G beta-galactosidase COG1874 Cluster_492177 V1241542 map00051,map00520,map01100,map02060 G PTS system sorbose subfamily IIB component COG3444 Cluster_557776 V1241543 map00051,map00520,map01100,map02060 G PTS system fructose IIA component COG2893 Cluster_163698 V1241544 AGAS map00250,map00520,map01100,map01110 M isomerase COG2222 Cluster_215014 V1241545 LACD map00052,map01100 G Aldolase COG3684 Cluster_201891 V1241546 GALM map00010,map01110,map01120 G converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) COG2017 Cluster_216152 V1241547 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_770037 V1241548 L DNA helicase COG1112 Cluster_371989 V1241549 S NA 1294N Cluster_36689 V1241550 SDHA map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map05134 C Succinate dehydrogenase (Flavoprotein subunit) COG1053 Cluster_51328 V1241551 DPRA L DNA protecting protein DprA COG0758 Cluster_429032 V1241552 SCLAV_4550 L UPF0102 protein COG0792 Cluster_1368 V1241553 S NA 0ZTYV Cluster_41042 V1241555 SDHA map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map05134 C Succinate dehydrogenase (Flavoprotein subunit) COG1053 Cluster_357108 V1241556 map02010 S YodA lipocalin-like domain 11KBP Cluster_123466 V1241557 ZNUA map02010 P transporter substrate-binding protein COG0803 Cluster_352087 V1241558 ZNUC map02010 P (ABC) transporter COG1121 Cluster_299478 V1241559 map02010 P abc-3 protein COG1108 Cluster_127501 V1241560 S Inherit from COG: ATPase (AAA COG1373 Cluster_173720 V1241561 SP_0571 D Cell filamentation protein Fic-related protein COG2184 Cluster_400044 V1241562 S Acetyltransferase (GNAT) family 11Z04 Cluster_801021 V1241563 K HTH_XRE 0XUC3 Cluster_543099 V1241564 S NA 0YRPX Cluster_109436 V1241566 AGCS E amino acid carrier protein COG1115 Cluster_202939 V1241567 S NA 124W6 Cluster_665614 V1241568 K Transcriptional regulator COG1695 Cluster_199905 V1241569 DINB L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity) COG0389 Cluster_232450 V1241570 S domain protein 0Y8F3 Cluster_51925 V1241571 OPPA E ABC transporter COG0747 Cluster_247754 V1241572 APPC map02010 P ABC superfamily ATP binding cassette transporter ABC protein COG1173 Cluster_227781 V1241573 OPPB E, P Oligopeptide ABC transporter, permease protein AppB COG0601 Cluster_217345 V1241574 OPPD E, P ABC transporter COG0444 Cluster_203983 V1241575 AQPZ G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) COG0580 Cluster_211621 V1241576 MENE map00130,map01100,map01110 H o-succinylbenzoic acid-CoA ligase COG0318 Cluster_186490 V1241577 AROB map00230,map00400,map01100,map01110,map01230 E 3-dehydroquinate synthase COG0337 Cluster_494662 V1241578 S transmembrane signal peptide protein COG3169 Cluster_512530 V1241579 S NA 11XVQ Cluster_421555 V1241580 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_644916 V1241581 YAJC map03060,map03070 U Preprotein translocase YajC subunit COG1862 Cluster_197911 V1241582 NUSB K Involved in the transcription termination process (By similarity) COG0781 Cluster_385913 V1241583 RPLY map03010 J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) COG1825 Cluster_546049 V1241584 HSLR J Heat shock protein COG1188 Cluster_419757 V1241585 PURN map00230,map00670,map01100,map01110 F phosphoribosylglycinamide formyltransferase COG0299 Cluster_57275 V1241586 V ABC transporter transmembrane region COG1132 Cluster_163699 V1241587 S DNA mismatch repair protein 0ZAAE Cluster_136697 V1241588 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_144227 V1241589 FPRA C domain protein COG0426 Cluster_203984 V1241590 GCVT map00260,map00670,map00910,map01100 E The glycine cleavage system catalyzes the degradation of glycine (By similarity) COG0404 Cluster_467261 V1241591 YRXA K 3H domain protein COG1827 Cluster_280382 V1241592 NADC map00760,map01100 H nicotinate-nucleotide pyrophosphorylase COG0157 Cluster_139002 V1241593 NADB map00250,map00760,map01100 H L-aspartate oxidase COG0029 Cluster_249072 V1241594 NADA map00760,map01100 H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) COG0379 Cluster_1985 V1241595 S cell wall surface anchor family protein 0XRFZ Cluster_387745 V1241596 S relaxase mobilization nuclease domain protein 0XNXG Cluster_30121 V1241597 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_149593 V1241598 O Antioxidant, AhpC TSA family 0ZMYB Cluster_425213 V1241599 S NA 0YRF6 Cluster_487330 V1241600 S NA 0Y736 Cluster_465174 V1241601 K RNA Polymerase 11MBG Cluster_46924 V1241602 SPEA map00330,map01100 E Catalyzes the biosynthesis of agmatine from arginine (By similarity) COG1166 Cluster_113510 V1241603 map00010,map00500 G glycoside hydrolase family 4 COG1486 Cluster_387746 V1241604 K HTH_XRE 0XUC3 Cluster_678741 V1241606 K Transcriptional regulator COG1396 Cluster_57516 V1241612 M Cell wall anchor domain protein 11Q8J Cluster_104008 V1241613 S NA 0Z3Y8 Cluster_172894 V1241614 map00051 M glycosyltransferase group 2 family protein COG0463 Cluster_139787 V1241615 GLF M udp-galactopyranose mutase COG0562 Cluster_400045 V1241616 PGN_0945 K Transcriptional regulator, TetR family 11T38 Cluster_520465 V1241620 S NA 0YZ4W Cluster_382369 V1241621 S NA 0YKYE Cluster_641036 V1241622 S NA 0Z7YS Cluster_4343 V1241624 ELI_1307 M phage tail tape measure protein COG5283 Cluster_342558 V1241625 S NA 0Z81M Cluster_10296 V1241626 S NA COG4926 Cluster_362022 V1241629 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_148828 V1241630 ARCA map00330,map01100,map01110 E Arginine dihydrolase COG2235 Cluster_215015 V1241631 ARGF map00330,map01100,map01110,map01230 E ornithine carbamoyltransferase COG0078 Cluster_255228 V1241632 ARCC map00230,map00330,map00910,map01120 E carbamate kinase COG0549 Cluster_657199 V1241633 GRXC O Glutaredoxin COG0695 Cluster_130351 V1241634 S Inherit from COG: ATPase (AAA COG1373 Cluster_353750 V1241635 S NA 128C9 Cluster_226639 V1241638 S NA 0XWFB Cluster_773727 V1241639 S Abortive infection protein AbiGI 11WH3 Cluster_614250 V1241640 S Abortive infection protein AbiGII 0XQHH Cluster_126807 V1241641 S NA 0ZE8A Cluster_10884 V1241642 OCAR_4226 L DEAD DEAH box helicase COG1204 Cluster_678744 V1241643 S Relaxase mobilization nuclease 0ZY81 Cluster_232451 V1241644 RHUM S DNA-binding protein COG3943 Cluster_492178 V1241645 AMYE map02010 G solute-binding protein COG1653 Cluster_25310 V1241646 map00550,map01100 M glycosyl transferase, family 51 COG0744 Cluster_277720 V1241647 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_14173 V1241649 PQQL O Peptidase, M16 COG0612 Cluster_246496 V1241650 XERD L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_512531 V1241651 AROQ map00400,map01051,map01100,map01110,map01230 E Catalyzes a trans-dehydration via an enolate intermediate (By similarity) COG0757 Cluster_385914 V1241652 MDMC map00340,map00350,map00360,map00624,map00940,map00941,map00945,map01100,map01110,map01120 S O-methyltransferase COG4122 Cluster_637044 V1241653 RBFA J Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) COG0858 Cluster_147297 V1241654 map02010 M Efflux ABC transporter, permease protein COG4591 Cluster_603286 V1241655 PGN_0102 K transcriptional repressor, copy family 11TR3 Cluster_29575 V1241657 S NA 0YFZR Cluster_25499 V1241658 S NA 11FZK Cluster_458918 V1241659 RIMM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) 11M4J Cluster_166888 V1241660 DXR map00900,map01100,map01110 I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) COG0743 Cluster_193495 V1241663 YEII map00240 G kinase (PfkB family COG0524 Cluster_433010 V1241664 TDK map00240,map00983,map01100 F thymidine kinase COG1435 Cluster_396589 V1241665 PPIB O PPIases accelerate the folding of proteins COG0652 Cluster_114219 V1241666 V Mate efflux family protein COG0534 Cluster_322978 V1241667 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_3015 V1241668 S NA 101UU Cluster_520466 V1241669 S NA 1229H Cluster_46528 V1241670 map02010 S Permease, YjgP YjgQ family 0XNZX Cluster_152056 V1241671 RIBBA map00740,map01100 H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) COG0807 Cluster_283128 V1241672 EXBB U MotA TolQ exbB proton channel COG0811 Cluster_373607 V1241673 S ExbD TolR family protein 11JMR Cluster_373608 V1241674 EXBD U Biopolymer transport protein exbD tolR 11TA0 Cluster_261687 V1241675 M tonB-dependent Receptor 11HUD Cluster_230111 V1241676 map02010,map02020,map05152 P Phosphate abc COG0226 Cluster_313763 V1241678 YBBP S TIGR00159 family COG1624 Cluster_281726 V1241679 FOLP map00790,map01100 H dihydropteroate synthase COG0294 Cluster_119900 V1241680 MURF map00300,map00550,map01100 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) COG0770 Cluster_57276 V1241681 EPTC S Phosphoethanolamine transferase COG2194 Cluster_512532 V1241683 S NA 0XT33 Cluster_16335 V1241685 SCLAV_1560 map02010 P ABC transporter COG1122 Cluster_77131 V1241686 NHAP P Potassium proton antiporter COG3263 Cluster_210488 V1241687 CZCD P cation diffusion facilitator family transporter COG0053 Cluster_385915 V1241688 S PAP2 Family 11IDI Cluster_2455 V1241689 PRTP O peptidase S8 and S53, subtilisin, kexin, sedolisin COG2247 Cluster_117001 V1241690 V Mate efflux family protein COG0534 Cluster_321417 V1241691 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_41385 V1241692 CADA P p-type atpase COG2217 Cluster_338153 V1241693 SSCG_03030 map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_25500 V1241694 S NA 0YWBS Cluster_105199 V1241695 MACB map02010 V abc transporter permease protein COG0577 Cluster_7528 V1241696 S NA 12BGB Cluster_178638 V1241697 TRPD map00400,map01100,map01110,map01230 E anthranilate phosphoribosyltransferase COG0547 Cluster_16812 V1241699 DNAQ map03420,map03430 L Uvrd rep helicase COG0210 Cluster_78116 V1241700 S fad dependent oxidoreductase COG2509 Cluster_30716 V1241702 CCSA O cytochrome C COG0755 Cluster_230112 V1241707 CICA E HAD-superfamily subfamily IB hydrolase COG0560 Cluster_118405 V1241708 S Membrane 0YHV8 Cluster_100021 V1241709 S Membrane 0YHV8 Cluster_230113 V1241710 M Glycosyl transferase, family 2 COG0463 Cluster_98442 V1241711 M Polysaccharide Biosynthesis Protein COG2244 Cluster_463096 V1241712 BCP O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG1225 Cluster_661410 V1241713 V abc transporter permease protein 0ZW5X Cluster_724964 V1241714 S NA 12CRX Cluster_509961 V1241716 RPLO map03010 J Binds to the 23S rRNA (By similarity) COG0200 Cluster_836251 V1241717 RPMD map03010 J 50S ribosomal protein L30 COG1841 Cluster_469386 V1241718 RPSE map03010 J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) COG0098 Cluster_603287 V1241719 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_449066 V1241720 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_824811 V1241721 RPSZ map03010 J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) COG0199 Cluster_445001 V1241722 RPLE map03010 J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COG0094 Cluster_665615 V1241723 RPLX map03010 J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) COG0198 Cluster_621656 V1241724 RPLN map03010 J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) COG0093 Cluster_738126 V1241725 RPSQ map03010 J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal COG0186 Cluster_797084 V1241726 RPMC map03010 J 50s ribosomal protein l29 COG0255 Cluster_295457 V1241727 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_637045 V1241728 RPLV map03010 J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) COG0091 Cluster_705436 V1241729 RPSS map03010 J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) COG0185 Cluster_285950 V1241730 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_692216 V1241731 RPLW map03010 J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) COG0089 Cluster_396590 V1241732 RPLD map03010 J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) COG0088 Cluster_384136 V1241733 RPLC map03010 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 Cluster_665616 V1241734 RPSJ map03010 J Involved in the binding of tRNA to the ribosomes (By similarity) COG0051 Cluster_389445 V1241738 map00230,map01100 F guanylate kinase COG0194 Cluster_477997 V1241740 FOLA map00670,map00790,map01100 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) COG0262 Cluster_473649 V1241745 ELI_1313 S phage structural protein 11WWI Cluster_27694 V1241746 PRIA map03440 L Primosomal protein n' COG1198 Cluster_389446 V1241747 S NA 11X82 Cluster_184699 V1241748 GLDN S gliding motility protein gldn 0ZWZA Cluster_77132 V1241749 GLDM S gliding motility-associated protein gldm 0XREI Cluster_309302 V1241750 GLDL S gliding motility-associated protein GldL 0XPKJ Cluster_738127 V1241751 S NA 0ZFWW Cluster_403608 V1241752 S NA 1212G Cluster_546050 V1241754 GG9_0942 L transposase COG2801 Cluster_35308 V1241755 YFJK L domain protein COG1204 Cluster_257743 V1241756 S Domain of unknown function (DUF1837) 11JZV Cluster_880088 V1241757 K Inherit from COG: Transcriptional regulator COG3655 Cluster_384137 V1241758 S Protein of unknown function (DUF1638) 11HVD Cluster_499837 V1241759 VBSC S Gnat family COG0456 Cluster_326060 V1241760 map00230 S phosphorylase 11F11 Cluster_405422 V1241761 S DJ-1 PfpI family protein 11Z3Y Cluster_661411 V1241762 Q Oxaloacetate decarboxylase, gamma chain 0XY4W Cluster_523230 V1241763 GCDC map00010,map00020,map00362,map00620,map00650,map01100,map01110,map01120 I biotin lipoyl attachment domaiN-containing protein COG0511 Cluster_172895 V1241764 GCDB map00330,map00362,map00620,map00650,map01100,map01120 C decarboxylase (Beta subunit) COG1883 Cluster_231286 V1241765 GCTA map00643,map00650,map01120 I coenzyme A transferase COG1788 Cluster_302237 V1241766 GCTB map00643,map00650,map01120 I Glutaconate CoA-transferase COG2057 Cluster_62091 V1241767 map00280,map00362,map00650,map01100,map01120 I glutaconyl-CoA decarboxylase COG4799 Cluster_291311 V1241768 HGDC I coA-substrate-specific enzyme activase COG1924 Cluster_124758 V1241769 HGDA map00362,map01100,map01120,map01220 E dehydratase COG1775 Cluster_169473 V1241770 HGDB map00362,map00363,map00626,map00650,map00903,map01100,map01110,map01120 E dehydratase COG1775 Cluster_86825 V1241771 FTSE map02010 D Cell division ATP-binding protein ftsE COG2884 Cluster_294049 V1241772 M Sortase family COG3764 Cluster_242543 V1241773 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_526139 V1241774 DEDA P SNARE associated Golgi COG0586 Cluster_232452 V1241776 ISPH map00900,map01100,map01110,map03010 I Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) COG0761 Cluster_1968 V1241777 S alpha-2-macroglobulin COG2373 Cluster_186491 V1241779 YCHF J gtp-binding protein COG0012 Cluster_211622 V1241780 S YitT family COG1284 Cluster_412525 V1241781 RDGB map00230,map00240,map01100 F Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) COG0127 Cluster_40866 V1241782 S Immunoreactive 84 kDa antigen 0Y0NA Cluster_94169 V1241783 S NA 0Y3ES Cluster_234909 V1241784 map00510,map01100 M Glycosyl Transferase COG0463 Cluster_232453 V1241786 M hydrolase, family 25 COG3757 Cluster_146522 V1241790 map04151,map04510,map04512,map04974,map05146,map05200,map05222 S Collagen triple helix repeat (20 copies) 0ZNMK Cluster_48541 V1241794 SGLY_0562 S NA 0ZU6E Cluster_387747 V1241798 OPUCB map02010 E ABC transporter COG1174 Cluster_220828 V1241799 OPUCC map02010 M Glycine betaine COG1732 Cluster_382370 V1241800 OPUCD map02010 E Glycine betaine carnitine choline COG1174 Cluster_740694 V1024002 S NA 0Y3II Cluster_617003 V1024003 NAGB map00520,map01100,map01110 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COG0363 Cluster_321100 V1024007 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_717508 V1024009 YJDJ S acetyltransferase COG2388 Cluster_714250 V1024010 YJJZ S Protein of unknown function (DUF1435) 17FXY@proNOG Cluster_701619 V1024016 S NA 0XUAX Cluster_613275 V1024019 TSGA G Protein TsgA homolog COG0477 Cluster_525422 V1024025 M RHS repeat-associated core domain protein COG3209 Cluster_351767 V1024028 V transporter, permease 10BP7 Cluster_385510 V1024031 TRAI S Conjugative transposon protein TraI 0YE08 Cluster_334729 V1024034 HYPE O hydrogenase expression formation protein (HypE) COG0309 Cluster_324235 V1024035 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_542267 V1024036 DCP E oligopeptidase A COG0339 Cluster_757745 V1024038 S NA 17D58@proNOG Cluster_325735 V1024043 S membrAne 120XT Cluster_424788 V1024044 IMPC S type VI secretion protein, EvpB VC_A0108 family COG3517 Cluster_325736 V1024046 S YSIRK type signal peptide 0YB7G Cluster_494058 V1024047 S Phosphoesterase COG4186 Cluster_412073 V1024048 K transcriptional regulator, luxR family COG2197 Cluster_444563 V1024050 SCPB K Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) COG1386 Cluster_403192 V1024051 BMUL_5652 L Transposase COG2801 Cluster_682181 V1024053 PHOR T Histidine kinase 0XNMH Cluster_530993 V1024054 PHOP T regulator COG0745 Cluster_668875 V1024056 RPLU map03010 J This protein binds to 23S rRNA in the presence of protein L20 (By similarity) COG0261 Cluster_440537 V1024057 SCLAV_0086 J gCN5-related N-acetyltransferase COG1670 Cluster_450571 V1024058 S tape measure domain protein 11PSY Cluster_327294 V1024060 CCRA L Cassette chromosome recombinase A COG1961 Cluster_436507 V1024061 M peptidase M23 0XQC5 Cluster_396214 V1024062 PCP O Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) COG2039 Cluster_733936 V1024063 L integrase family 0XRS7 Cluster_406714 V1024071 SLYD O peptidylprolyl cis-trans isomerase COG1047 Cluster_328831 V1024073 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG4199 Cluster_330214 V1024074 BMUL_2943 G Major Facilitator Superfamily 0XNST Cluster_691188 V1024075 TTCA D Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) COG0037 Cluster_340741 V1024077 G Major Facilitator superfamily 172BD@proNOG Cluster_328832 V1024083 CYSE map00270,map00920,map01100,map01120,map01230 E serine acetyltransferase COG1045 Cluster_835284 V1024085 RPMD map03010 J 50S ribosomal protein L30 1036C Cluster_460468 V1024086 RPSE map03010 J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) COG0098 Cluster_330215 V1024087 YIDE P transport protein COG2985 Cluster_862974 V1024089 STHA map00010,map00020,map00260,map00280,map00480,map00620,map00760,map01100,map01110,map01120 C Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) COG1249 Cluster_506677 V1024091 BCGIA V Type II restriction modification enzyme methyltransferase COG0286 Cluster_412074 V1024094 TOPB L Dna topoisomerase COG0550 Cluster_528246 V1024095 S Inherit from NOG: domain protein 18D01@proNOG Cluster_717509 V1024096 S prevent-host-death family 0ZX42 Cluster_624506 V1024097 RPLT map03010 J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) COG0292 Cluster_331786 V1024099 FIC D cell filamentation protein COG2184 Cluster_545251 V1024101 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_368327 V1024102 COBW S CobW P47K family protein COG0523 Cluster_831325 V1024103 BIOY map02010 S bioY protein COG1268 Cluster_796123 V1024104 MT2808 S Protein of unknown function (DUF3046) 12CIG Cluster_331787 V1024105 S NA 11QTV Cluster_392602 V1024106 BDBD O disulfide bond COG1651 Cluster_908202 V1024107 K Inherit from COG: Transcriptional regulator COG3655 Cluster_479830 V1024108 S Phosphodiesterase, mj0936 family 1AJJN@sphNOG Cluster_816064 V1024114 RPMC map03010 J 50s ribosomal protein l29 COG0255 Cluster_737209 V1024115 RPSQ map03010 J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal COG0186 Cluster_346980 V1024117 RADC L DNA repair protein (RadC COG2003 Cluster_496554 V1024119 S interferon-induced transmembrane protein 121MN Cluster_380181 V1024127 TNPB L integrase catalytic COG2801 Cluster_333247 V1024128 CG2937 E Extracellular solute-binding protein, family 5 COG0747 Cluster_380182 V1024132 YFEH G Bile acid COG0385 Cluster_403193 V1024133 S membrAne 0YEM5 Cluster_333249 V1024134 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_333250 V1024135 M NA 0ZYVM Cluster_334730 V1024139 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_509304 V1024140 S NA 0ZHU9 Cluster_639987 V1024142 V Type I restriction modification system COG0286 Cluster_737210 V1024143 V Type I restriction modification system COG0286 Cluster_598858 V1024144 PQQL O Peptidase, M16 COG0612 Cluster_334731 V1024147 SUCB map00010,map00020,map00280,map00310,map00620,map01100,map01110,map01120 C 2-oxoglutarate dehydrogenase E2 component, dihydrolipoamide succinyltransferase COG0508 Cluster_360093 V1024150 S membrane protein involved in aromatic hydrocarbon degradation 0YMT5 Cluster_635922 V1024151 YQII map05133 S Fimbrial 17708@proNOG Cluster_891200 V1024152 YQII map05133 S Fimbrial 17708@proNOG Cluster_887167 V1024153 YQII map05133 S Fimbrial 10VJC Cluster_643908 V1024154 YAAQ S protein from nitrogen regulatory protein P-II COG3870 Cluster_501747 V1024155 LNT M Transfers the fatty acyl group on membrane lipoproteins (By similarity) COG0815 Cluster_765312 V1024156 RPSR map03010 J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) COG0238 Cluster_617004 V1024157 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_769176 V1024159 DARB map00061,map01100 I synthase III COG0332 Cluster_710833 V1024161 S NA 1236P Cluster_482160 V1024162 map00230 S NUDIX hydrolase 11K18 Cluster_664539 V1024164 T response regulator COG2197 Cluster_468896 V1024169 S outer membrane lipoprotein carrier protein 11YKN Cluster_337802 V1024170 EAEH map05100 S K13735 adhesin invasin 16SKU@proNOG Cluster_479831 V1024171 RLMH S Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) COG1576 Cluster_525423 V1024172 YQIW S UPF0403 protein 11J34 Cluster_504193 V1024173 NUDC map00760,map04146 L nadh pyrophosphatase COG2816 Cluster_727375 V1024174 MT3294 P TrkA-N domain protein COG1226 Cluster_464695 V1024175 COMF map00230,map00250,map01100,map01110 S Competence protein COG1040 Cluster_765313 V1024183 RPMC map03010 J 50s ribosomal protein l29 COG0255 Cluster_682182 V1024184 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_450572 V1024185 BMUL_5790 L transposase COG4644 Cluster_808235 V1024186 S NA 17RV0@proNOG Cluster_827735 V1024187 BMUL_5788 S Plasmid replication region DNA-binding N-term 17D0B@proNOG Cluster_551266 V1024188 TNPT S Cointegrate resolution protein T 173WC@proNOG Cluster_757746 V1024189 HISG map00340,map01100,map01110,map01230 E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) COG0040 Cluster_530994 V1024190 ASPA map00250,map00910,map01100 E Aspartate ammonia-lyase COG1027 Cluster_361658 V1024191 map02010 E amino acid COG0683 Cluster_339286 V1024192 S NA 124TN Cluster_397956 V1024200 DSBD O Thiol disulfide interchange protein COG4232 Cluster_128901 V1241801 map00680 C Na H antiporter COG1757 Cluster_36690 V1241802 M efflux transporter, rnd family, mfp subunit COG0845 Cluster_341039 V1241803 MACB2 V Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) COG1136 Cluster_141275 V1241804 V ABC transporter, permease COG0577 Cluster_76429 V1241806 map02010 P Transporter Permease Protein COG1178 Cluster_242544 V1241807 map02010 E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COG3842 Cluster_465175 V1241808 PGPA map00564,map01100 I phosphatidylglycerophosphatase a COG1267 Cluster_492179 V1241811 OGT L Methyltransferase COG0350 Cluster_59591 V1241812 S Membrane 0ZI5H Cluster_209412 V1241813 LTAE map00260,map01100,map01110,map01120,map01230 E Aldolase COG2008 Cluster_398311 V1241815 ATPD map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG1394 Cluster_111432 V1241816 ATPB map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) COG1156 Cluster_172896 V1241817 MTLD map00051 G mannitol-1-phosphate 5-dehydrogenase COG0246 Cluster_45174 V1241818 MTLR K TRANSCRIPTIONal COG3711 Cluster_60145 V1241819 MTLA map00051,map02060 G PTS system mannitol-specific COG2213 Cluster_55002 V1241820 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_451030 V1241822 S NA 0YQFJ Cluster_140525 V1241823 S NA 0XRRN Cluster_60656 V1241824 CPDB map00230,map00240,map00760,map01100,map01110 F 5-nucleotidase COG0737 Cluster_309303 V1241825 NUDC map00760,map04146 L nadh pyrophosphatase COG2816 Cluster_128902 V1241826 YIEG S Xanthine uracil vitamin C permease COG2252 Cluster_23285 V1241828 N Cell surface protein 0XQ7Y Cluster_128903 V1241834 S Collagen triple helix repeat (20 copies) 17JU4@proNOG Cluster_73862 V1241838 SGLY_0562 S NA 0ZU6E Cluster_322979 V1241841 AMET_0437 S NA 11YKG Cluster_153664 V1241842 AMET_0436 S Bacteriophage protein COG3299 Cluster_629149 V1241843 AMET_0435 S NA 0ZBNM Cluster_665618 V1241846 L NA 0YKV1 Cluster_718298 V1241847 L NA 0YJFA Cluster_748187 V1241849 K Inherit from COG: Transcriptional regulator COG3655 Cluster_162059 V1241850 HINDVM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_60393 V1241851 M Cell wall anchor domain protein 11Q8J Cluster_306580 V1241852 SCLAV_4722 J Methyltransferase COG2813 Cluster_206149 V1241853 NTPC map00190,map00680,map01100 C ATP synthase subunit C COG1527 Cluster_669900 V1241854 NTPG map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG1436 Cluster_108804 V1241855 map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) COG1156 Cluster_378870 V1241856 ATPD map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG1394 Cluster_333572 V1241857 YAAA L UPF0246 protein COG3022 Cluster_275088 V1241859 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_460971 V1241860 S conjugative transposon protein TraC 0ZU3R Cluster_6319 V1241861 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_5743 V1241862 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_73520 V1241864 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_708523 V1241865 GROS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) COG0234 Cluster_394814 V1241866 OGT L Methyltransferase COG0350 Cluster_586058 V1241867 RPLQ map03010 J 50S ribosomal protein l17 COG0203 Cluster_236111 V1241868 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_566996 V1241869 RPSK map03010 J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) COG0100 Cluster_603288 V1241870 RPSM map03010 J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits COG0099 Cluster_738130 V1241871 BL05010 S ribosomal protein L14e 0XUZY Cluster_384138 V1241872 ADK map00230,map00240,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_134283 V1241873 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_515231 V1241874 RPLO map03010 J Binds to the 23S rRNA (By similarity) COG0200 Cluster_836253 V1241875 RPMD map03010 J 50S ribosomal protein L30 COG1841 Cluster_734771 V1241876 S NA 0ZHU9 Cluster_114889 V1241877 MUTL2 map00660,map01100 S glutamate mutase, mutL 0XRSI Cluster_60146 V1241878 HUTU map00340,map01100 E Urocanate hydratase COG2987 Cluster_128904 V1241879 S Na H antiporter COG2056 Cluster_151222 V1241880 HUTI map00340,map01100 Q imidazolone-5-propionate hydrolase COG1228 Cluster_434928 V1241881 FCHA map00670,map01100 E Methenyltetrahydrofolate cyclohydrolase COG3404 Cluster_120627 V1241882 GABT map00250,map00410,map00640,map00650,map01100 E 4-aminobutyrate aminotransferase COG0160 Cluster_31741 V1241883 M phosphoglycerol transferase COG1368 Cluster_22201 V1241884 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_100568 V1241885 ALGI M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_797085 V1241888 K Transcriptional regulator 123HS Cluster_661412 V1241889 S NA 11JTA Cluster_119135 V1241890 PEPC E aminopeptidase c COG3579 Cluster_114890 V1241891 PEPC E aminopeptidase c COG3579 Cluster_514 V1241892 S NA 0YZ82 Cluster_69616 V1241900 S NA 0YAGY Cluster_309304 V1241902 S Virulence-associated protein e COG5545 Cluster_48765 V1241903 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_300859 V1241904 H thiF family COG0476 Cluster_31083 V1241905 CADA P heavy metal translocating p-type ATPase COG2217 Cluster_79159 V1241906 FPRB map00250,map00910,map01100,map01110,map01120,map01230 C reductase COG0493 Cluster_299479 V1241907 MRP D ATP-binding protein COG0489 Cluster_180338 V1241908 HIPO map00360 E amidohydrolase COG1473 Cluster_257744 V1241909 S PEP phosphonomutase family protein 0XPW8 Cluster_92366 V1241910 V ABC transporter transmembrane region 0YGB0 Cluster_14571 V1241911 SPAT map02010 V ABC transporter 0XPIZ Cluster_353751 V1241913 YABB map00340,map00350,map00624,map01120 L Methyltransferase COG4123 Cluster_284503 V1241914 RSMI G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 Cluster_239896 V1241915 S NurA domain protein 11IQE Cluster_53050 V1241916 S Domain of unknown function DUF87 0ZJHN Cluster_99495 V1241917 GLGA map00500,map01100,map01110,map04973 G Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) COG0297 Cluster_220829 V1241918 N Cell surface protein 0XQ7Y Cluster_241173 V1241919 WHIA K May be required for sporulation (By similarity) COG1481 Cluster_715059 V1241920 PTSH G phosphocarrier protein (HPr COG1925 Cluster_8006 V1241921 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0587 Cluster_233715 V1241922 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G phosphohexokinase COG0205 Cluster_62092 V1241923 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG0469 Cluster_336605 V1241924 L Membrane COG4905 Cluster_62903 V1241927 M Cell wall anchor domain protein 11Q8J Cluster_188189 V1241928 M Sortase family COG3764 Cluster_3597 V1241929 S NA 11NI8 Cluster_238624 V1241931 S Acyltransferase family 0YFSP Cluster_15644 V1241932 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_110745 V1241933 S NA 0ZY1A Cluster_560828 V1241938 LGAS_0613 S phage protein 125MW Cluster_122164 V1241941 XKDK S phage protein 0XRSE Cluster_517903 V1241942 LGAS_0617 S XkdM protein, phage-like element PBSX 11FZB Cluster_517904 V1241943 LGAS_0618 S XkdN-like protein 11VQZ Cluster_28767 V1241944 S Tape measure protein COG5281 Cluster_375321 V1241945 S domain protein COG1652 Cluster_90916 V1241946 LGAS_0621 S Phage cell wall hydrolase 0XSRY Cluster_107060 V1241948 S NA 11ZCV Cluster_382372 V1241949 XKDP S Inherit from COG: domain protein COG1652 Cluster_44663 V1241950 S NA COG5412 Cluster_563810 V1241952 S Phage XkdN-like protein 0Y1N4 Cluster_531722 V1241953 XKDM S phage-like element pbsx protein XkdM 124NI Cluster_185572 V1241954 S phage-like element pbsx protein xkdK 0ZVHW Cluster_540198 V1241956 LGAS_0613 S phage protein 125MW Cluster_143476 V1241959 S NA 11SPJ Cluster_1544 V1241960 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_9569 V1241961 HSDR V Type I Restriction COG0610 Cluster_134284 V1241962 V Restriction modification system DNA (Specificity COG0732 Cluster_78788 V1241963 HSDM V type I restriction-modification system COG0286 Cluster_403609 V1241970 THYX map00240,map00340,map00350,map00624,map00670,map01120 F Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) COG1351 Cluster_523231 V1241975 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_142778 V1241977 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (alpha subunit) COG0587 Cluster_41221 V1241978 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (alpha subunit) COG0587 Cluster_8007 V1241981 PYC map00020,map00620,map00720,map01100,map01120,map01230 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) COG1038 Cluster_669901 V1241982 PSPC S phage shock protein C, PspC COG1983 Cluster_33122 V1241983 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_407090 V1241984 COMF S Competence protein COG1040 Cluster_246498 V1241985 YIHY S ribonuclease BN COG1295 Cluster_824812 V1241986 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_93750 V1241987 NUOM map00190,map00910,map01100 C subunit m COG1008 Cluster_98972 V1241988 NUON map00190,map00910,map01100 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) COG1007 Cluster_19291 V1241989 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_353752 V1241990 ISPD map00900,map01100,map01110 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COG1211 Cluster_199906 V1241991 MBL D Rod shape-determining protein mreb COG1077 Cluster_728261 V1241992 PTSH G phosphocarrier protein hpr COG1925 Cluster_281727 V1241993 YBBP S TIGR00159 family COG1624 Cluster_224349 V1241994 S YbbR-like protein COG4856 Cluster_114220 V1241996 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_363591 V1241997 MTNN map00270,map01100 F Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) COG0775 Cluster_112048 V1241998 BL01171 P hemerythrin hhe cation binding domain protein COG2461 Cluster_338155 V1241999 S NA 0ZCBM Cluster_618004 V1242000 S Membrane protein of unknown function 0ZIET Cluster_596204 V1242001 S NA 129EW Cluster_6114 V1242002 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0047 Cluster_114891 V1242003 PURF map00230,map00250,map01100,map01110 F glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_105200 V1242005 RND J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) COG0349 Cluster_96821 V1242006 P Chloride channel COG0038 Cluster_168542 V1242008 S domain protein 0Y8F3 Cluster_412526 V1242009 K RNA Polymerase COG1595 Cluster_315346 V1242010 S NA 100T6 Cluster_279082 V1242011 O DnaJ domain protein COG0484 Cluster_371990 V1242012 S NA 12AV7 Cluster_300860 V1242013 OPPF map02010 E (ABC) transporter COG4608 Cluster_232454 V1242014 APPD map02010 E, P ABC transporter COG0444 Cluster_281728 V1242015 DPPC map02010 P abc transporter, permease COG1173 Cluster_243899 V1242016 DPPB P ABC transporter (Permease COG0601 Cluster_12388 V1242018 S Inherit from NOG: antigen PG97 COG4886 Cluster_166889 V1242020 S NA 0YF9C Cluster_410717 V1242021 map02020 T response regulator COG2197 Cluster_447048 V1242022 C Nitroreductase COG0778 Cluster_357109 V1242023 YQXD S UPF0178 protein COG1671 Cluster_174534 V1242024 LYTR K TRANSCRIPTIONal COG1316 Cluster_152894 V1242025 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_540199 V1242026 S DNA-binding protein with PD1-like DNA-binding motif COG1661 Cluster_494663 V1242027 MGSA map00620 G methylglyoxal synthase COG1803 Cluster_705438 V1242028 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_451031 V1242029 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_773730 V1242030 RPSR map03010 J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) COG0238 Cluster_89517 V1242031 WS0013 S membrAne 0XPGN Cluster_368658 V1242032 S Nitrogen regulatory protein P-II 11PAT Cluster_2181 V1242033 O cysteine protease COG4870 Cluster_46729 V1242034 L DNA polymerase 0XRUF Cluster_576513 V1242035 S NA 122IS Cluster_271066 V1242036 YUT E UreA transporter COG4413 Cluster_19208 V1242037 S peptidase C10 11SDT Cluster_95209 V1242038 YCAM E amino acid COG0531 Cluster_152057 V1242039 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_162895 V1242040 MDH map00620,map00710,map01100,map01120,map02020 C malate dehydrogenase (Oxaloacetate-decarboxylating) COG0281 Cluster_132657 V1242041 MLEP map02020 C citrate carrier protein COG3493 Cluster_294051 V1242042 S Transporter, auxin efflux carrier (AEC) family protein COG0679 Cluster_16878 V1242043 G domain protein 11V8D Cluster_509962 V1242044 S NA 125EB Cluster_400046 V1242045 K Transcriptional regulator, TetR family COG1309 Cluster_407091 V1242046 BMUL_5533 S NA 0XPT9 Cluster_197913 V1242047 map00540,map01100 M heptosyltransferase COG0859 Cluster_296801 V1242049 S Protein of unknown function (DUF3108) 11Z9Q Cluster_407092 V1242050 RNFA C Electron transport complex COG4657 Cluster_417982 V1242051 RNFE C Electron transport complex COG4660 Cluster_421556 V1242052 RNFG C Electron transport complex COG4659 Cluster_217346 V1242053 RNFD C Electron transport complex COG4658 Cluster_73863 V1242054 YSH1 J Metallo-Beta-Lactamase COG1236 Cluster_48542 V1242055 GLGB map00500,map01100,map01110,map04973 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) COG0296 Cluster_171980 V1242056 GLGC map00500,map00520,map01100,map01110 G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) COG0448 Cluster_101702 V1242057 GLGA map00500,map01100,map01110,map04973 G Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) COG0297 Cluster_74187 V1242059 PHOB map00627,map00790,map01100,map01120,map02020 P alkaline phosphatase COG1785 Cluster_193496 V1242060 S Membrane 11ZHS Cluster_127502 V1242062 S nucleoside recognition domain protein COG3314 Cluster_186492 V1242063 L Integrase COG0582 Cluster_338156 V1242064 K HTH_XRE 0Z8AS Cluster_49969 V1242066 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_355422 V1242067 RSMG M Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) COG0357 Cluster_146523 V1242068 CINA H competence damage-inducible protein COG1546 Cluster_318450 V1242069 SOJ D Chromosome Partitioning Protein COG1192 Cluster_296802 V1242070 PARB K parb-like partition protein COG1475 Cluster_9427 V1242071 M Peptidase family S41 COG0793 Cluster_305194 V1242075 SCLAV_2398 T response regulator COG2197 Cluster_100022 V1242076 T Histidine kinase COG4585 Cluster_198905 V1242077 YHFE E m42 family COG1363 Cluster_528904 V1242078 AROQ map00400,map01051,map01100,map01110,map01230 E Catalyzes a trans-dehydration via an enolate intermediate (By similarity) COG0757 Cluster_469387 V1242079 AROK map00400,map01100,map01110,map01230 E Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) COG0703 Cluster_198906 V1242080 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_145729 V1242081 AROA map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate synthase COG0128 Cluster_212711 V1242082 AROB map00230,map00400,map01100,map01110,map01230 E 3-dehydroquinate synthase COG0337 Cluster_292671 V1242083 AROF map00400,map01100,map01110,map01230 E phospho-2-dehydro-3-deoxyheptonate aldolase COG2876 Cluster_309305 V1242084 AROE map00400,map01100,map01110,map01230 E shikimate dehydrogenase COG0169 Cluster_3483 V1242085 S Cleaved adhesin domain protein 0Y522 Cluster_20378 V1242086 SPEB S peptidase C10 11SDT Cluster_236112 V1242088 map03440 L ATP-dependent exodnase (exonuclease v) COG0507 Cluster_469388 V1242091 AMET_0423 S NA 120SA Cluster_456937 V1242093 AMET_0425 S NA 0XYD9 Cluster_218482 V1242094 AMET_0426 S Protein of unknown function (DUF3383) 11UPU Cluster_563811 V1242095 AMET_0427 S NA 0XUEQ Cluster_38838 V1242098 M phage tail tape measure protein COG5283 Cluster_497171 V1242099 AMET_0431 S NA 0YU9Y Cluster_678747 V1242100 AMET_0432 S NA 0Y2IT Cluster_279083 V1242101 AMET_0433 S NA 11WKE Cluster_184700 V1242102 SRTB U sortase, SrtB family COG4509 Cluster_233716 V1242105 TDH G, M epimerase dehydratase COG0451 Cluster_582865 V1242106 PSP1 J endoribonuclease L-psp COG0251 Cluster_629150 V1242107 RSFS S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) COG0799 Cluster_423415 V1242108 YQEK map00760,map01100 H Metal Dependent Phosphohydrolase COG1713 Cluster_414406 V1242109 NADD map00230,map00760,map01100,map05340 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) COG1057 Cluster_695985 V1242110 YHBY J Rna-binding protein COG1534 Cluster_139788 V1242111 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_699270 V1242112 RPMA map03010 J 50S ribosomal protein l27 COG0211 Cluster_669903 V1242114 RPLU map03010 J This protein binds to 23S rRNA in the presence of protein L20 (By similarity) COG0261 Cluster_38316 V1242115 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0550 Cluster_408864 V1242116 map00920,map01100,map01120 E, H (phospho)adenosine phosphosulfate reductase COG0175 Cluster_49163 V1242117 map00920,map01100,map01120 E, H (phospho)adenosine phosphosulfate reductase COG0175 Cluster_7574 V1242118 SCLAV_2518 S AtP-binding protein 0YS2R Cluster_621657 V1242119 ARSC P Transcriptional regulator, Spx MgsR family COG1393 Cluster_163700 V1242120 NAGZ map00460,map00500,map00520,map00940,map01100,map01110 G hydrolase family, 3 COG1472 Cluster_385916 V1242121 TRMB C Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_338157 V1242122 FABG map00061,map00780,map01040,map01100 S reductase 0XNW1 Cluster_70544 V1242123 PPAC map00190 C Manganese-dependent inorganic pyrophosphatase COG1227 Cluster_114221 V1242124 V Mate efflux family protein COG0534 Cluster_82126 V1242125 GRDC C reductase complex component C 0XQ4S Cluster_170340 V1242126 GRDD S fatty acid phospholipid synthesis protein plsX 0XQ1G Cluster_268421 V1242127 S YitT family COG1284 Cluster_307886 V1242128 PDXK map00750,map01100 H Pyridoxal kinase COG2240 Cluster_109437 V1242129 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_198907 V1242130 S kila-n, DNA-binding domain 0XPNQ Cluster_121400 V1242131 MVK map00900,map01100,map01110,map04146 I mevalonate kinase COG1577 Cluster_191672 V1242133 RBSA1 S ABC transporter COG3845 Cluster_194430 V1242134 S basic membrane COG1744 Cluster_517905 V1242135 ELAA S gCN5-related N-acetyltransferase COG2153 Cluster_159551 V1242136 P Sodium hydrogen exchanger 0XRVN Cluster_632996 V1242137 S NA 1259M Cluster_172897 V1242138 DSDA map00260 E d-serine deaminase COG3048 Cluster_180339 V1242139 S NA 0Y7YG Cluster_445002 V1242140 S Toxin-antitoxin system, toxin component 0XRRU Cluster_589367 V1242141 K DNA-binding helix-turn-helix protein 11XIQ Cluster_37330 V1242142 TEX K domain protein COG2183 Cluster_551974 V1242143 ATTT S acetyltransferase, (GNAT) family 11VF3 Cluster_335076 V1242144 map02010 P Cobalt transport protein COG0619 Cluster_284504 V1242145 CBIO2 map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_280383 V1242146 CBIO1 map02010 P ABC transporter COG1122 Cluster_255229 V1242147 RIHC map00230,map00240,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_48322 V1242148 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_23881 V1242149 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_665619 V1242150 RSBV T stage II sporulation protein COG1366 Cluster_321418 V1242152 SIGB K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG1191 Cluster_221990 V1242153 LPLA map00785,map01100 H Lipoate-protein, ligase COG0095 Cluster_276419 V1242154 LIPA map00785,map01100 H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) COG0320 Cluster_58799 V1242155 MDLA V ABC transporter, ATP-binding protein COG1132 Cluster_287358 V1242156 SUHB map00521,map00562,map01100,map01110,map04070 G inositol monophosphatase COG0483 Cluster_32997 V1242157 L Reverse transcriptase (RNA-dependent DNA polymerase) COG3344 Cluster_147298 V1242158 S NA 17SFZ@proNOG Cluster_692217 V1242159 S NA 0ZRDA Cluster_137485 V1242160 TRAM S conjugative transposon 0YI63 Cluster_283129 V1242162 map02010 P abc-3 protein COG1108 Cluster_367046 V1242163 ADCC map02010 P ABC transporter COG1121 Cluster_135072 V1242164 ZNUA map02010 P transporter substrate-binding protein COG0803 Cluster_107641 V1242165 S PHP domain protein 11TE8 Cluster_502370 V1242166 PSPE P domain protein COG0607 Cluster_492180 V1242167 ISPF map00900,map01100,map01110 I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) COG0245 Cluster_336606 V1242168 ISPD map00900,map01100,map01110 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COG1211 Cluster_193497 V1242169 YACL S PilT protein domain protein COG4956 Cluster_492181 V1242170 CARD K Transcriptional regulator (CarD family COG1329 Cluster_109438 V1242171 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_130352 V1242172 CLPC O chaperone COG0542 Cluster_89518 V1242173 S phage Tail Protein 0Z1N7 Cluster_3590 V1242174 S NA 0ZMA4 Cluster_49373 V1242178 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_242545 V1242179 DUSB J Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_39482 V1242180 GLNN map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG3968 Cluster_599717 V1242181 SP_2199 S Domain of unknown function DUF77 COG0011 Cluster_319939 V1242182 TAUC map02010 P binding-protein-dependent transport systems inner membrane Component COG0600 Cluster_207243 V1242183 TAUA map02010 P ABC transporter substrate-binding protein COG0715 Cluster_324563 V1242184 TAUB P ATP-binding protein COG1116 Cluster_313764 V1242185 YCSF E lamb ycsf family protein COG1540 Cluster_153665 V1242186 YCSG P transporter COG1914 Cluster_327614 V1242187 KIPI E Allophanate hydrolase, subunit 1 COG2049 Cluster_237307 V1242188 KIPA E Allophanate hydrolase subunit 2 COG1984 Cluster_302238 V1242189 BMUL_5125 S UPF0317 protein COG4336 Cluster_224350 V1242190 S NA 0ZKM4 Cluster_401832 V1242191 S NA 11YRV Cluster_139003 V1242192 S NA 11I4B Cluster_225518 V1242193 MOXR2 S MCM2/3/5 family COG0714 Cluster_429033 V1242194 S NA 0Z9F2 Cluster_12420 V1242195 S Inherit from NOG: antigen PG97 COG4886 Cluster_11728 V1242196 M NA 0YER0 Cluster_425214 V1242197 GMHA map00540,map01100 M Isomerase COG0279 Cluster_288719 V1242198 LGTA map00051 M Glycosyl transferase, family 2 0ZVME Cluster_370361 V1242199 M Bacterial sugar transferase COG2148 Cluster_285951 V1242200 WECG M Glycosyl transferase, wecb taga cpsf family COG1922 Cluster_44664 V1242201 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_256453 V1242202 E, G Membrane COG0697 Cluster_265693 V1242204 MSCS M mechanosensitive ion channel COG0668 Cluster_773731 V1242205 YYZM S protein, conserved in bacteria COG4481 Cluster_152895 V1242206 ILVA map00260,map00290,map01100,map01110,map01230 E threonine COG1171 Cluster_520468 V1242207 HSP map04141 O Heat shock protein COG0071 Cluster_201892 V1242208 S capsid protein 11WXB Cluster_423416 V1242210 LGAS_0609 S Phage minor structural protein GP20 123J7 Cluster_859665 V1242211 S NA 0ZCX1 Cluster_110063 V1242212 LGAS_0607 T head morphogenesis protein, SPP1 gp7 COG5585 Cluster_116300 V1242213 LGAS_0606 S Phage Portal Protein 0XP33 Cluster_101151 V1242214 AMET_0415 S phage protein 0Y97T Cluster_467262 V1242215 S NA 11XM2 Cluster_125417 V1242216 M group 2 family 0XRCB Cluster_154464 V1242217 V abc transporter permease protein COG0577 Cluster_261689 V1242218 S YitT family COG1284 Cluster_262983 V1242219 PPX2 map00230 F, P ppx gppa phosphatase COG0248 Cluster_35709 V1242220 PPK map00190,map03018 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) COG0855 Cluster_163701 V1242221 NIFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_475803 V1242222 S NA 11U8H Cluster_781211 V1242223 TNP L transposase COG1943 Cluster_40389 V1242224 M Cell wall anchor domain protein 11Q8J Cluster_377086 V1242225 CAS4 L crispr-associated protein Cas4 COG1468 Cluster_203985 V1242226 CAS1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) COG1518 Cluster_695986 V1242227 CAS2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) COG1343 Cluster_77133 V1242228 L Resolvase COG1961 Cluster_394815 V1242230 K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) COG1974 Cluster_570081 V1242233 S Hypothetical protein (DUF2513) 0ZN21 Cluster_797087 V1242235 CDPW8_0150 K Antirepressor COG3645 Cluster_458919 V1242237 YCGH Q isochorismatase COG1335 Cluster_175348 V1242239 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_653071 V1242240 S Protein of unknown function (DUF3467) 11UAG Cluster_3737 V1242241 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_537402 V1242242 map00633,map01120 C nitroreductase COG0778 Cluster_73864 V1242243 IORA C indolepyruvate ferredoxin oxidoreductase COG4231 Cluster_425215 V1242244 IORB C indolepyruvate ferredoxin oxidoreductase COG1014 Cluster_126105 V1242245 E Aminotransferase class i COG0436 Cluster_683292 V1242246 CLPS O Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) COG2127 Cluster_27365 V1242247 CLPA O ATP-dependent Clp protease ATP-binding subunit ClpA COG0542 Cluster_57277 V1242248 map02010 V ABC transporter 0XPIZ Cluster_58042 V1242249 map02010 V ABC transporter 0XPIZ Cluster_173721 V1242250 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_166890 V1242251 THII map00730,map01100,map04122 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) COG0301 Cluster_74494 V1242252 YSH1 J Metallo-Beta-Lactamase COG1236 Cluster_475805 V1242253 FECA P Receptor COG4772 Cluster_27969 V1242254 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_380600 V1242255 S hemolysin III COG1272 Cluster_400047 V1242257 map00330,map01100 E Peptidyl-arginine deiminase 11XJA Cluster_58043 V1242258 DEAD map03018 L dead deah box COG0513 Cluster_373609 V1242260 S NA 0Y3II Cluster_245175 V1242261 S Relaxase mobilization nuclease 11PW0 Cluster_260373 V1242262 S NA 0ZC4R Cluster_197914 V1242263 S NA 11F7I Cluster_377087 V1242264 L helicase COG0553 Cluster_119136 V1242265 K, L domain protein COG0553 Cluster_610582 V1242266 V Endonuclease 1276E Cluster_309306 V1242267 METK S methionine adenosyltransferase 0YTXD Cluster_728262 V1242268 RECQ map03018 L ATP-dependent DNA helicase RecQ COG0514 Cluster_207244 V1242269 PFOR S Membrane COG3641 Cluster_92367 V1242270 PEPD E Dipeptidase COG4690 Cluster_718299 V1242271 L Addiction module antitoxin, RelB DinJ family COG3077 Cluster_196981 V1242272 MSRA O reductase COG0229 Cluster_360447 V1242273 S NA 0XUHN Cluster_188190 V1242274 YFMR S ABC transporter, ATP-binding protein COG0488 Cluster_22355 V1242278 S NA 0Z0IY Cluster_148094 V1242279 S NA 0YYRM Cluster_55501 V1242280 S NA 0ZXPF Cluster_11908 V1242281 L helicase 0XQCP Cluster_715060 V1242283 HUP L DNA-binding protein COG0776 Cluster_236113 V1242284 BMUL_5920 S Rhomboid family COG0705 Cluster_171158 V1242285 S Endonuclease Exonuclease phosphatase 11EFS Cluster_280385 V1242286 DEGV S degv family COG1307 Cluster_319940 V1242287 THYX map00240,map00340,map00350,map00624,map00670,map01120 F Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) COG1351 Cluster_108805 V1242288 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_91870 V1242289 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_107061 V1242290 VAG V Mate efflux family protein COG0534 Cluster_148095 V1242293 O AhpC Tsa family 0ZVMV Cluster_260374 V1242295 C Binding Domain protein COG0348 Cluster_35572 V1242296 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_148829 V1242297 S ATPase (AAA COG1373 Cluster_157831 V1242298 USP S CHAP domain protein COG3942 Cluster_158699 V1242299 PATA map00300,map01100,map01110,map01230 E Aminotransferase COG0436 Cluster_313765 V1242300 RECO map03440 L Involved in DNA repair and RecF pathway recombination (By similarity) COG1381 Cluster_216154 V1242301 PLSX map00561,map00564,map01100 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) COG0416 Cluster_347356 V1242302 PURC map00230,map01100,map01110 F SAICAR synthetase COG0152 Cluster_60657 V1242303 V ABC transporter COG1132 Cluster_185573 V1242304 GSPF map03070 U type ii secretion system COG1459 Cluster_250326 V1242305 SELD map00450,map01100 E Synthesizes selenophosphate from selenide and ATP (By similarity) COG0709 Cluster_110746 V1242306 SELA map00450,map00970 E Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) COG1921 Cluster_47871 V1242307 SELB map00450,map00970 J Selenocysteine-specific translation elongation factor COG3276 Cluster_360448 V1242308 REGX3 map02020 T response regulator COG0745 Cluster_79486 V1242309 SPOVB M Polysaccharide Biosynthesis Protein COG2244 Cluster_427137 V1242310 THIJ S intracellular protease Pfpi family COG0693 Cluster_367047 V1242311 ISPD map00900,map01100,map01110 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COG1211 Cluster_37177 V1242312 RECG map03440 L ATP-dependent DNA helicase recg COG1200 Cluster_218483 V1242313 M peptidase M23 COG0739 Cluster_315347 V1242315 M group 2 family COG0463 Cluster_148096 V1242317 CAP5O map00051,map00363,map00520,map00591,map00625,map00650,map01100,map01120 M Dehydrogenase COG0677 Cluster_171159 V1242318 CAP5I M Capsular Polysaccharide COG0438 Cluster_45572 V1242319 S NA 0Y92Z Cluster_42778 V1242323 S NA 0Z3TH Cluster_665620 V1242326 ARSR K Transcriptional regulator, arsR family COG0640 Cluster_599718 V1242327 ARSD P Arsenical resistance operon tranS-acting repressor 11UF3 Cluster_60394 V1242328 D ec 3.6.3.16 COG0003 Cluster_195311 V1242329 ARSB P arsenicaL-resistance protein COG0798 Cluster_150459 V1242331 S NA 11K37 Cluster_669904 V1242334 HIGA S plasmid maintenance system antidote protein, xre family 0XURZ Cluster_661413 V1242335 S Plasmid maintenance system killer 11WBR Cluster_489681 V1242336 S NA 0YHXE Cluster_3225 V1242340 S NA 12BGB Cluster_632997 V1242342 L Inherit from NOG: transposase 11VUP Cluster_824813 V1242343 CLCAR_1980 P iron permease, FTR1 COG0672 Cluster_108191 V1242344 GATA map00970,map01100 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) COG0154 Cluster_102266 V1242345 GATB map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 Cluster_412527 V1242346 PUCB map00230,map01100,map01120 O 4-diphosphocytidyl-2c-methyl-d-erythritol synthase COG2068 Cluster_295458 V1242347 YQEB O Selenium-dependent molybdenum hydroxylase system protein, YqeB family COG1975 Cluster_315348 V1242348 O Dehydrogenase COG1975 Cluster_1062 V1242349 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_618005 V1242350 RPLT map03010 J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) COG0292 Cluster_817003 V1242351 RPMI map03010 J 50s ribosomal protein L35 COG0291 Cluster_416177 V1242352 INFC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) COG0290 Cluster_398312 V1242353 UDK map00240,map00710,map00983,map01100,map01120 F uridine monophosphokinase COG0572 Cluster_147299 V1242354 YEGQ map05120 O Peptidase U32 COG0826 Cluster_69266 V1242355 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_507358 V1242356 FUR P Ferric uptake COG0735 Cluster_546051 V1242358 RUVX L Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) COG0816 Cluster_738132 V1242359 YRZL S UPF0297 protein COG4472 Cluster_512533 V1242360 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_111433 V1242361 VEX1 V ABC transporter, permease COG0577 Cluster_345766 V1242362 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_353753 V1242364 PSSA map00260,map00564,map01100 I cdpdiacylglycerol-serine O-phosphatidyltransferase COG1183 Cluster_355423 V1242365 PSD map00564,map01100 I Phosphatidylserine decarboxylase proenzyme COG0688 Cluster_5877 V1242366 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III alpha subunit COG0587 Cluster_347357 V1242367 ARAD map00040,map00053,map01100,map01120 G L-ribulose-5-phosphate 4-epimerase COG0235 Cluster_273733 V1242368 SGAU map00040,map00053,map01100,map01120 G L-xylulose 5-phosphate 3-epimerase COG3623 Cluster_370362 V1242369 SGBH map00030,map00040,map00053,map00680,map01100,map01120,map01230 G decarboxylase COG0269 Cluster_485046 V1242370 SP_2036 map00053,map01100,map01120,map02060 G PTS System 11Q8R Cluster_708527 V1242371 SGAB map00053,map01100,map01120,map02060 G PTS System COG3414 Cluster_259068 V1242372 PFLX S radical SAM domain protein COG1313 Cluster_215016 V1242373 HYDE map00780,map01100 H radical SAM domain protein COG0502 Cluster_101152 V1242374 HYDG map00730,map01100 H biosynthesis protein thiH COG1060 Cluster_177802 V1242375 HYDF S gtp-binding protein COG1160 Cluster_58283 V1242376 V ABC transporter COG1132 Cluster_731564 V1242378 S Signal peptide protein, YSIRK family 1293E Cluster_267009 V1242379 UPPP map00550 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) COG1968 Cluster_344149 V1242380 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_159552 V1242381 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_11160 V1242382 O cysteine protease COG4870 Cluster_65397 V1242383 S CAMP factor (Cfa) 0Z1YX Cluster_209413 V1242384 S cAMP factor 0YS1B Cluster_96822 V1242385 PCNA map03013,map03018 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate COG0617 Cluster_436989 V1242387 S Domain of Unknown Function (DUF1599) 0XPSN Cluster_37019 V1242388 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_467263 V1242389 S NA 0ZJXE Cluster_105814 V1242391 AMYA2 map00500,map01100 G hydrolase family 57 COG1449 Cluster_120628 V1242392 map00051 M Glycosyl transferase (Group 1 COG0438 Cluster_45956 V1242393 map00500,map01100 G Glycogen debranching enzyme COG3408 Cluster_665623 V1242394 CELB map02060 G PTS system cellobiose transporter subunit IIB COG1440 Cluster_755065 V1242395 SP_0304 S MtN3 and saliva related transmembrane protein COG4095 Cluster_99496 V1242396 CELA map00010 G 6-phospho-beta-glucosidase (EC 3.2.1.86) COG2723 Cluster_163702 V1242398 G Major Facilitator Superfamily 0XQVS Cluster_111434 V1242399 M serine-type D-Ala-D-Ala carboxypeptidase COG1686 Cluster_11325 V1242400 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_342559 V1242402 S TIM-barrel fold 11FGY Cluster_194431 V1242403 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E amino acid aminotransferase COG0115 Cluster_53284 V1242404 CAPD map00051,map00362,map00363,map00521,map00523,map00591,map00625,map00626,map00650,map00903,map01055,map01100,map01110,map01120 M Polysaccharide biosynthesis protein COG1086 Cluster_112049 V1242405 M carboxy-peptidase COG1876 Cluster_674300 V1242406 TRXA O Thioredoxin COG0526 Cluster_182995 V1242407 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_408865 V1242408 NADD map00230,map00760,map01100,map05340 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) COG1057 Cluster_423417 V1242409 YQEK map00760,map01100 H Metal Dependent Phosphohydrolase COG1713 Cluster_27186 V1242410 M hydrolase, family 25 COG3757 Cluster_183814 V1242411 YCHF J gtp-binding protein COG0012 Cluster_367048 V1242412 FOLA map00670,map00790,map01100 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) COG0262 Cluster_509963 V1242413 S NA 0Z5C1 Cluster_8682 V1242414 S tonB-dependent receptor plug 0XNX2 Cluster_632998 V1242415 K Transcriptional regulator COG0789 Cluster_785316 V1242416 S NA 11TQ2 Cluster_277722 V1242417 S conjugative transposon membrane protein 0XPC1 Cluster_252767 V1242418 C Inherit from COG: radical SAM domain protein COG1032 Cluster_570082 V1242419 S NA 11FZQ Cluster_25311 V1242420 TRSE U traE protein COG3451 Cluster_232455 V1242421 CFR9IM L DNA Methylase COG0863 Cluster_469389 V1242422 S Inherit from NOG: chap domain containing protein 0XP7Y Cluster_683293 V1242424 S NA 1258Z Cluster_357111 V1242425 P membrAne COG2717 Cluster_534511 V1242426 C FMN-binding domain protein COG3976 Cluster_55756 V1242427 V abc transporter COG1132 Cluster_333574 V1242428 J Glutamine amidotransferase COG2071 Cluster_124104 V1242429 V Mate efflux family protein COG0534 Cluster_265694 V1242430 SSCG_06117 S degv family COG1307 Cluster_173722 V1242431 E DegT/DnrJ/EryC1/StrS aminotransferase family COG0520 Cluster_423418 V1242433 YEDF map04122 S selenium metabolism protein yedf 11NCC Cluster_194432 V1242434 SELD map00450,map01100 E Synthesizes selenophosphate from selenide and ATP (By similarity) COG0709 Cluster_512534 V1242435 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_106420 V1242436 SCLAV_4792 G Major Facilitator superfamily 0XQD0 Cluster_198908 V1242437 map05100 S NA 0XZM9 Cluster_55502 V1242438 S domain protein 0YF83 Cluster_189032 V1242439 S 5-bromo-4-chloroindolyl phosphate hydrolysis protein 111JX Cluster_177803 V1242440 TELA P Resistance protein COG3853 Cluster_134285 V1242441 S Membrane 0XPGQ Cluster_241174 V1242442 RBSC-2 S abc transporter, permease COG1079 Cluster_182996 V1242443 RBSC-1 S ABC transporter (Permease) COG4603 Cluster_142779 V1242444 RIBBA map00740,map01100 H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) COG0807 Cluster_443013 V1242446 S NA 128GQ Cluster_227782 V1242447 map00051,map00510,map01100 M group 2 family COG0463 Cluster_456938 V1242448 S NA 0Y7HB Cluster_208369 V1242449 APBE M thiamine biosynthesis lipoprotein apbE COG1477 Cluster_371992 V1242450 T Transcription regulator 101GZ Cluster_439020 V1242453 CHRA P Chromate COG2059 Cluster_284505 V1242454 S abc transporter permease protein 124X7 Cluster_344150 V1242455 YHCG V abc transporter atp-binding protein COG1131 Cluster_143477 V1242456 YAAO map00310,map00330,map00960,map01100,map01110 E decarboxylase COG1982 Cluster_313766 V1242457 YRAE S Hydrolase COG0561 Cluster_20152 V1242458 YHGE S domain protein COG1511 Cluster_360449 V1242459 RPSD map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) COG0522 Cluster_718300 V1242460 S Protein of unknown function (DUF1021) COG4466 Cluster_528905 V1242461 S NA 0Z3BG Cluster_507359 V1242462 PYRI map00240,map00250,map01100 F Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) COG1781 Cluster_125418 V1242463 GLYA map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01230 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) COG0112 Cluster_296803 V1242465 PLSC map00561,map00564,map01100 I Acyl-transferase COG0204 Cluster_164499 V1242466 S metallophosphoesterase COG1408 Cluster_119901 V1242467 PYRC map00240,map01100 F Dihydroorotase COG0044 Cluster_275089 V1242468 S (LipO)protein 104XX Cluster_537403 V1242469 S NA 0Y02D Cluster_625452 V1242470 S Septum formation 0Y0EZ Cluster_728264 V1242471 O Glutaredoxin 125U3 Cluster_312270 V1242473 map00362,map01100,map01120 C Hydrolase COG0596 Cluster_81348 V1242474 MURF map00300,map00550,map01100 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) COG0770 Cluster_158700 V1242475 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_36874 V1242476 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_504775 V1242477 SMPB O Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) COG0691 Cluster_74820 V1242478 L DNA mismatch repair protein COG0249 Cluster_336607 V1242480 S TraX protein 11N9P Cluster_122165 V1242482 RIBF map00740,map01100 H riboflavin biosynthesis protein ribF COG0196 Cluster_231287 V1242484 NANA map00300,map00520,map01100,map01110,map01120,map01230 E dihydrodipicolinate COG0329 Cluster_252768 V1242485 K Transcriptional regulator, LysR family COG0583 Cluster_232456 V1242486 E (ABC) transporter COG4608 Cluster_207245 V1242487 GSIA map02010 E, P ABC transporter COG0444 Cluster_261690 V1242488 DPPC P ABC transporter permease protein COG1173 Cluster_243900 V1242489 DPPB E, P Binding-protein-dependent transport system inner membrane component COG0601 Cluster_81349 V1242490 DPPA E Extracellular solute-binding protein, family 5 COG0747 Cluster_618006 V1242492 OGT L methyltransferase COG3695 Cluster_394816 V1242493 S Predicted metal-binding protein (DUF2284) 11T5J Cluster_32709 V1242494 S tetratricopeptide repeat 0YK8K Cluster_259069 V1242495 P NMT1/THI5 like COG0715 Cluster_6320 V1242496 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_155300 V1242497 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_39631 V1242498 V ABC transporter COG1132 Cluster_39151 V1242500 RRGB M Lpxtg-motif cell wall anchor domain protein 0XSEP Cluster_279084 V1242502 LGT M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 Cluster_54538 V1242504 map02010 V ABC transporter 0XPIZ Cluster_63182 V1242505 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_92817 V1242506 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_163703 V1242511 S phage protein 0XQDU Cluster_417983 V1242512 S Phage-associated protein 11FS5 Cluster_43494 V1242513 L DNA polymerase 0XRUF Cluster_702337 V1242514 RPLW map03010 J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) COG0089 Cluster_287359 V1242515 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_637048 V1242516 RPLV map03010 J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) COG0091 Cluster_318451 V1242517 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_596205 V1242518 RPLN map03010 J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) COG0093 Cluster_674301 V1242519 RPLX map03010 J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) COG0198 Cluster_443014 V1242520 RPLE map03010 J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COG0094 Cluster_566997 V1242521 RPSH map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) COG0096 Cluster_449068 V1242522 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_603291 V1242523 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_632999 V1242524 S NA 0YQK2 Cluster_290003 V1242525 FTSQ map04112 M domain protein, FtsQ-type COG1589 Cluster_339577 V1242526 YLXW S division initiation protein COG3879 Cluster_339578 V1242527 YLXW S division initiation protein COG3879 Cluster_641037 V1242528 SBP S small basic protein COG3856 Cluster_187330 V1242529 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_576514 V1242530 NRDR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) COG1327 Cluster_55757 V1242533 V abc transporter COG1132 Cluster_326061 V1242534 GLNQ map02010 E ABC transporter, ATP-binding protein COG1126 Cluster_251544 V1242535 TRXB map00240,map00450 O Thioredoxin reductase COG0492 Cluster_111435 V1242536 CYCA E amino acid COG1113 Cluster_95210 V1242537 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_385917 V1242538 LIN2373 V Abortive infection bacteriophage resistance protein COG4823 Cluster_91386 V1242540 THRC map00260,map00750,map01100,map01120,map01230 E Threonine synthase COG0498 Cluster_135073 V1242541 NORM V Mate efflux family protein COG0534 Cluster_528906 V1242542 SP_2062 K Transcriptional regulator COG1846 Cluster_603292 V1242543 S Membrane COG3759 Cluster_280386 V1242544 S Protein of unknown function (DUF3737) 0XTHF Cluster_165350 V1242545 PATB map00270,map00450,map00920,map01100,map01110,map01230 E Aminotransferase class I and II COG1168 Cluster_187331 V1242546 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_191673 V1242548 PHEB map00400,map01100,map01110,map01230 E Chorismate mutase COG2876 Cluster_268422 V1242549 S Tetratricopeptide repeat protein 0XUD3 Cluster_131902 V1242550 HUTI map00340,map01100 Q imidazolone-5-propionate hydrolase COG1228 Cluster_92818 V1242551 HUTH map00340,map01100 E Histidine ammonia-lyase COG2986 Cluster_338158 V1242552 S NA 0YSQN Cluster_114892 V1242553 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_515232 V1242554 RPLI map03010 J Binds to the 23S rRNA (By similarity) COG0359 Cluster_42600 V1242555 YYBT T domain protein COG3887 Cluster_238625 V1242556 S Predicted membrane protein (DUF2232) 11PQ9 Cluster_38994 V1242558 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_271067 V1242559 S Membrane 0XSC7 Cluster_265695 V1242560 E, G Membrane COG0697 Cluster_11433 V1242561 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_777460 V1242562 S NA 0ZQJ3 Cluster_596206 V1242563 S NA 11W01 Cluster_138249 V1242564 ULAG map00053,map01100,map01120 S L-ascorbate 6-phosphate lactonase COG2220 Cluster_132658 V1242565 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_419758 V1242566 L Membrane COG4905 Cluster_458920 V1242567 T Two component LuxR family transcriptional regulator COG2197 Cluster_210489 V1242568 CCPA K Transcriptional regulator COG1609 Cluster_259070 V1242569 DAGK I Diacylglycerol kinase COG1597 Cluster_477998 V1242570 S NA 0XWY0 Cluster_434929 V1242571 S general stress protein 0XVE3 Cluster_262984 V1242572 RLUD J pseudouridine synthase COG0564 Cluster_300861 V1242573 PPNK map00760,map01100 G Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) COG0061 Cluster_74495 V1242574 S domain protein 0YF83 Cluster_92819 V1242576 CSX8 L CRISPR-associated protein Csx8 0ZHRD Cluster_27465 V1242577 CAS3 L CRISPR-associated helicase, cas3 COG1203 Cluster_153666 V1242578 E peptidase 0XRNU Cluster_62904 V1242579 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 Cluster_46730 V1242580 RECQ2 map03018 L ATP-dependent DNA helicase RecQ COG0514 Cluster_58546 V1242581 O m6 family metalloprotease domain protein COG4412 Cluster_285952 V1242582 C Binding Domain protein 11NY9 Cluster_82127 V1242584 COMEC S ComEC rec2-like protein COG0658 Cluster_319941 V1242585 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_475806 V1242586 S sporulation and cell division repeat protein 11VBB Cluster_543100 V1242587 L Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) COG0816 Cluster_433013 V1242588 DEF J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) COG0242 Cluster_370363 V1242589 S Tetratricopeptide repeat COG0457 Cluster_249073 V1242590 E, G EamA-like transporter family COG0697 Cluster_45573 V1242591 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_156966 V1242592 FPRA C domain protein COG0426 Cluster_288720 V1242593 TTCA D Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) COG0037 Cluster_285953 V1242594 VICX map03013 S domain protein COG1235 Cluster_148097 V1242595 M O-Antigen Polymerase COG3307 Cluster_219639 V1242596 ARGF map00330,map01100,map01110,map01230 E ornithine carbamoyltransferase COG0078 Cluster_497172 V1242597 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_27466 V1242598 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_403610 V1242599 ENGB S Necessary for normal cell division and for the maintenance of normal septation (By similarity) COG0218 Cluster_259071 V1242600 YPUA S secreted protein COG4086 Cluster_243901 V1242601 GLSA map00250,map00330,map00471,map00910,map01100,map01120,map04724,map04727,map04964 E Glutaminase COG2066 Cluster_224351 V1242602 map00330,map00340,map01100 E agmatinase (EC 3.5.3.11) COG0010 Cluster_59891 V1242603 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG3848 Cluster_231288 V1242604 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G phosphohexokinase COG0205 Cluster_456939 V1242606 S NA 127K0 Cluster_309307 V1242608 LPXA map00540,map01100 M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) COG1043 Cluster_109439 V1242609 M efflux transporter, outer membrane factor lipoprotein, NodT family COG1538 Cluster_534512 V1242610 AROQ map00400,map01051,map01100,map01110,map01230 E Catalyzes a trans-dehydration via an enolate intermediate (By similarity) COG0757 Cluster_193498 V1242611 NRDB map00230,map00240,map00480,map01100,map04115 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_127503 V1242612 HEMZ map00860,map01100,map01110 H coproporphyrinogen III oxidase COG0635 Cluster_232457 V1242614 YABE M domain protein COG3584 Cluster_502372 V1242615 TRML map04122 J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) COG0219 Cluster_28669 V1242616 DNAQ map03022,map03420 L helicase COG1199 Cluster_785317 V1242617 SECE map03060,map03070 U preprotein translocase subunit SecE 0ZYWA Cluster_445003 V1242618 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_499838 V1242619 RPLK map03010 J This protein binds directly to 23S ribosomal RNA (By similarity) COG0080 Cluster_344151 V1242620 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_425216 V1242621 ADK map00230,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_447049 V1242622 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_86386 V1242623 NNRD G Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) COG0063 Cluster_210490 V1242624 FBA map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01230 G Fructose-1,6-bisphosphate aldolase, class II COG0191 Cluster_335077 V1242625 AQPZ G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) COG0580 Cluster_353754 V1242626 YDJZ S SNARE associated Golgi protein-related protein COG0398 Cluster_365336 V1242627 C SNARE associated Golgi COG0398 Cluster_358782 V1242628 map00051 M Glycosyl transferase, family 2 11FDR Cluster_232458 V1242629 C iron-sulfur 11G02 Cluster_128191 V1242630 S NA 0XNUC Cluster_781213 V1242631 S NA 12BJS Cluster_84719 V1242632 CYDA map00190,map01100,map02020 C (Ubiquinol oxidase) subunit I COG1271 Cluster_171981 V1242633 CYDB map00190,map01100,map02020 C cytochrome D ubiquinol oxidase subunit II COG1294 Cluster_2431 V1242636 S Family of unknown function (DUF490) 0Z0C5 Cluster_225519 V1242637 WBPI map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_150460 V1242638 M glycosyl transferase group 1 0ZWDI Cluster_313767 V1242639 YGFM map00450 C FAD binding domain in molybdopterin dehydrogenase 0YU1D Cluster_504776 V1242640 map00633,map00680,map00720,map01120 C domain protein COG2080 Cluster_29576 V1242641 XDHD map00230,map00450,map01100,map01120 C Xanthine dehydrogenase COG1529 Cluster_353755 V1242642 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_113511 V1242643 TRKA P potassium transporter peripheral membrane COG0569 Cluster_96300 V1242644 TRKH P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) COG0168 Cluster_106421 V1242645 TRKA P potassium transporter peripheral membrane COG0569 Cluster_169474 V1242646 CZCD P cation diffusion facilitator family transporter COG0053 Cluster_766323 V1242647 YKUJ S Protein of unknown function (DUF1797) COG4703 Cluster_34911 V1242648 FEOB P ferrous iron transport protein COG0370 Cluster_218484 V1242649 LYTR K TRANSCRIPTIONal COG1316 Cluster_34033 V1242650 F ATP cone domain COG1328 Cluster_467264 V1242651 NRDG O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) COG0602 Cluster_162060 V1242652 YXBA S ATP-grasp COG3919 Cluster_699271 V1242653 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_509964 V1242654 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_773733 V1242655 RPSR map03010 J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) COG0238 Cluster_665624 V1242656 S rRNA biogenesis protein Rrp5 0XUK3 Cluster_29189 V1242658 BL03493 L phage plasmid primase, p4 family COG3378 Cluster_708528 V1242659 S VRR-NUC domain protein 122HE Cluster_111436 V1242660 K, L domain protein COG0553 Cluster_487331 V1242661 S NA 0YFX8 Cluster_405423 V1242662 RIBE map00740,map01100 H riboflavin synthase, subunit alpha COG0307 Cluster_380601 V1242663 GPH map00630,map01100,map01110 S Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) COG0546 Cluster_202940 V1242665 YCEG F aminodeoxychorismate lyase COG1559 Cluster_141276 V1242667 AROA map00400,map01100,map01110,map01230 E 3-phosphoshikimate 1-carboxyvinyltransferase COG0128 Cluster_563812 V1242668 S NA 11SIY Cluster_451032 V1242669 S domain protein 0XS27 Cluster_144228 V1242670 HIPO map00360 E amidohydrolase COG1473 Cluster_166891 V1242671 P permease COG0628 Cluster_398313 V1242672 TDK map00240,map00983,map01100 F thymidine kinase COG1435 Cluster_324564 V1242673 ECSA map02010 V ABC, transporter COG1131 Cluster_70545 V1242674 S ABC transporter, permease 11NJ6 Cluster_176963 V1242675 T response regulator COG2208 Cluster_174535 V1242676 YPSC L Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) COG0116 Cluster_614254 V1242677 SORA C Superoxide reductase COG2033 Cluster_288721 V1242678 NRDE map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_205061 V1242679 FABK map00061,map01100 I 2-Nitropropane dioxygenase COG2070 Cluster_245176 V1242680 FABD map00061,map01100 I malonyl CoA-acyl carrier protein transacylase COG0331 Cluster_333575 V1242681 FABG map00061,map00780,map01040,map01100 I reductase 0XNW1 Cluster_146524 V1242682 FABF map00061,map00780,map01100 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) COG0304 Cluster_489682 V1242683 ACCB map00061,map00253,map00620,map00640,map00720,map01100,map01110,map01120 I Acetyl-CoA carboxylase, biotin carboxyl carrier protein COG0511 Cluster_540200 V1242684 FABZ map00061,map00540,map00780,map01100 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) COG0764 Cluster_563813 V1242686 S Toxin-antitoxin system, antitoxin component, HicB family 11KI8 Cluster_454997 V1242687 HSDS V restriction COG0732 Cluster_163704 V1242688 V restriction COG0732 Cluster_76430 V1242689 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_60966 V1242690 V ABC transporter COG1132 Cluster_198909 V1242691 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_318452 V1242692 LPXH map00540,map01100 S udp-2,3-diacylglucosamine hydrolase COG2908 Cluster_657201 V1242693 YITW O fes assembly suf system protein COG2151 Cluster_272401 V1242694 ACCD map00061,map00253,map00620,map00640,map00720,map01100,map01110,map01120 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) COG0777 Cluster_315349 V1242695 ACCA map00061,map00253,map00620,map00640,map00720,map01100,map01110,map01120 I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) COG0825 Cluster_114893 V1242696 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_251545 V1242697 MANN map00051,map00520,map01100,map02060 G PTS system mannose fructose sorbose family transporter subunit IID COG3716 Cluster_6020 V1242698 CAFA map03018 J ribonuclease COG1530 Cluster_97889 V1242699 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_192610 V1242700 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_208370 V1242701 S PAP2 superfamily domain protein 11HHM Cluster_419759 V1242702 PNCA map00760,map01100 Q nicotinamidase COG1335 Cluster_499839 V1242703 RIMP S Required for maturation of 30S ribosomal subunits (By similarity) 11NQG Cluster_139004 V1242704 NUSA K Transcription elongation factor NusA COG0195 Cluster_180340 V1242705 WBSE S Glycosyl transferase 0XSUN Cluster_220830 V1242706 M group 2 family COG0463 Cluster_89519 V1242707 M polysaccharide biosynthesis protein 11G5Z Cluster_112050 V1242709 DAPE map00300,map01100,map01120,map01230 E peptidase COG0624 Cluster_277723 V1242710 METQ map02010 P Lipoprotein COG1464 Cluster_290004 V1242711 map02010 E ABC transporter substrate-binding protein COG0834 Cluster_836255 V1242713 YCHM P sulfate transporter COG0659 Cluster_173723 V1242715 S NMT1/THI5 like 11IV9 Cluster_371993 V1242716 P Binding-protein-dependent transport systems, inner membrane component COG0600 Cluster_447050 V1242717 ENTB Q Isochorismatase, hydrolase 11I3F Cluster_166162 V1242718 S transporter gate domain protein 0XRV8 Cluster_312271 V1242719 S TraX protein 11N9P Cluster_357112 V1242721 J Glutamine amidotransferase COG2071 Cluster_139005 V1242722 GRDE S reductase 0XPPI Cluster_892266 V1242723 GRDA S reductase complex 0XWGN Cluster_648990 V1242724 GRDA C In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination 11JMA Cluster_197915 V1242725 GRDB S Selenoprotein B, glycine betaine sarcosine D-proline reductase family 0XPCF Cluster_762376 V1242726 S selenoprotein B, glycine betaine sarcosine D-proline reductase 123JW Cluster_83011 V1242727 GRDC C reductase complex component C 0XQ4S Cluster_160394 V1242728 GRDD S fatty acid phospholipid synthesis protein plsX 0XQ1G Cluster_322980 V1242729 COBM map00860,map01100 H precorrin-4 C(11)-methyltransferase COG2875 Cluster_231289 V1242730 CBIG map00860,map01100 H biosynthesis protein (CbiG) COG2073 Cluster_341040 V1242731 COBJ map00860,map01100 H Precorrin-3B C17-methyltransferase COG1010 Cluster_321419 V1242732 COBK map00860,map01100 H reductase COG2099 Cluster_692218 V1242733 S Cysteine-rich small domain protein COG2158 Cluster_451033 V1242734 COBU map00860,map01100 H Adenosylcobinamide kinase COG2087 Cluster_341041 V1242735 COBS map00860,map01100 H Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) COG0368 Cluster_425217 V1242736 COBC map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_114894 V1242737 DAPE1 map00300,map00310,map00330,map00780,map01100,map01110,map01120,map01210,map01230 E peptidase COG0624 Cluster_251546 V1242738 S Aminoglycoside phosphotransferase 0XP56 Cluster_182997 V1242739 NRNA J phosphoesterase RecJ domain protein COG0618 Cluster_385918 V1242740 S NA 0Y5ZK Cluster_247755 V1242741 S radical SAM domain protein COG0535 Cluster_236114 V1242742 C iron-sulfur 11G02 Cluster_91871 V1242743 map00680,map01120 S Phosphotransferase 0Y7VB Cluster_321420 V1242744 S Rhodanese-like domain 11QSF Cluster_116301 V1242745 MNME S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 Cluster_315350 V1242746 JAG S Single-stranded nucleic acid binding R3H domain-containing protein COG1847 Cluster_347358 V1242747 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins COG0706 Cluster_618007 V1242748 RNPA J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) COG0594 Cluster_892267 V1242749 RPMH map03010 J 50S ribosomal protein l34 0ZYGP Cluster_357113 V1242751 T response regulator COG0745 Cluster_14572 V1242752 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_405424 V1242753 S integral membrane protein 11Q41 Cluster_129620 V1242754 HOM E saf domain-containing protein COG4091 Cluster_150461 V1242755 S hi0933 family COG2081 Cluster_330510 V1242756 NPDA map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_165351 V1242757 URAA F permease COG2233 Cluster_318453 V1242758 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_439022 V1242759 NUDF map00230 F nudix hydrolase COG0494 Cluster_300862 V1242760 map00230,map00240,map00760,map01100,map01110 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) COG0005 Cluster_128905 V1242761 DEOA map00240,map00983,map01100,map05219 F The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) COG0213 Cluster_384139 V1242762 SPOIVFB S Peptidase M50 COG1994 Cluster_329110 V1242763 SCPA S Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) COG1354 Cluster_454998 V1242764 SCPB K Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) COG1386 Cluster_357114 V1242765 RLUB J Pseudouridine synthase COG1187 Cluster_755067 V1242766 YTQB map00340,map00350,map00624,map01120 Q rRNA Methylase COG0500 Cluster_178640 V1242767 LYTR K TRANSCRIPTIONal COG1316 Cluster_458921 V1242768 S Gcn5-related n-acetyltransferase 11VJM Cluster_98973 V1242769 PBUG S Xanthine uracil vitamin C permease COG2252 Cluster_295459 V1242770 YITU S hydrolase COG0561 Cluster_718301 V1242771 S NA 0XRX8 Cluster_443015 V1242772 S NA 129D9 Cluster_458922 V1242773 RAIA J ribosomal subunit Interface protein COG1544 Cluster_44840 V1242774 YUXL E Acetyl xylan esterase (AXE1) COG1506 Cluster_460972 V1242775 IRC4 S Protein of unknown function (DUF1706) COG4283 Cluster_271068 V1242776 S prophage antirepressor 17798@proNOG Cluster_625453 V1242777 WXCM S Domain-Containing protein 11PAN Cluster_126808 V1242783 GCVPA map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG0403 Cluster_582867 V1242784 GCVH map00630,map01110 E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) COG0509 Cluster_187332 V1242785 GCVT map00260,map00670,map00910,map01100 E The glycine cleavage system catalyzes the degradation of glycine (By similarity) COG0404 Cluster_38495 V1242786 P Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) COG4206 Cluster_141277 V1242787 RIBF map00740,map01100 H riboflavin biosynthesis protein ribF COG0196 Cluster_162896 V1242788 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_589368 V1242789 YJGF J endoribonuclease L-psp COG0251 Cluster_236115 V1242790 PPAX map00190,map00630,map01051,map01100,map01110 S had-superfamily hydrolase, subfamily ia, variant COG0546 Cluster_231290 V1242791 HPRA map00260,map00630,map00680,map01100,map01110,map01120,map01230 C glycerate dehydrogenase COG1052 Cluster_439023 V1242795 S NA 11NM2 Cluster_61278 V1242796 S Inherit from NOG: peptidase inhibitor activity 0XX92 Cluster_789337 V1242799 O Glutaredoxin COG4545 Cluster_363592 V1242800 RESD map02020 T Two component transcriptional regulator, winged helix family COG0745 Cluster_112051 V1242801 T Histidine kinase 0XNMH Cluster_283130 V1242803 COBQ map00860,map01100,map02010 H catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) COG1492 Cluster_333576 V1242804 S Protein of unknown function (DUF2807) 11HJ3 Cluster_592733 V1242806 K Transcriptional regulator, GntR family COG1725 Cluster_22952 V1242807 P tonB-dependent Receptor 0XP5Y Cluster_465177 V1242808 T cyclic nucleotide-binding domain protein COG0664 Cluster_249074 V1242809 CYSK map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_456940 V1242810 CYSE map00270,map00920,map01100,map01120,map01230 E serine acetyltransferase COG1045 Cluster_215017 V1242811 S NA 0XTJ4 Cluster_185574 V1242812 GLDA map00561,map01100 C glycerol dehydrogenase COG0371 Cluster_78789 V1242813 S Membrane 125GN Cluster_352088 V1242814 S NA 11QRM Cluster_371994 V1242816 S B3 4 domain protein COG3382 Cluster_563814 V1242817 L mutator MutT protein COG0494 Cluster_110747 V1242818 NHAD P Na H antiporter COG1055 Cluster_400048 V1242819 TAG map03410 L Dna-3-methyladenine glycosylase i COG2818 Cluster_111437 V1242820 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_22953 V1242821 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_220831 V1242822 MCSB map00330 E ATP guanido phosphotransferase COG3869 Cluster_467265 V1242823 MCSA S Uvrb UvrC protein COG3880 Cluster_512535 V1242824 CTSR K transcriptional regulator, ctsr COG4463 Cluster_27889 V1242825 S tonB-dependent Receptor 0YAYV Cluster_246499 V1242826 I alpha/beta hydrolase fold COG0657 Cluster_142001 V1242827 UGD map00040,map00053,map00500,map00520,map01100,map01110 M UDP-glucose 6-dehydrogenase COG1004 Cluster_309308 V1242828 YGDL H uba thif-type nad fad binding protein COG1179 Cluster_272402 V1242829 YITL S S1 RNA binding domain protein COG2996 Cluster_363593 V1242830 LOLD map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_35710 V1242831 NAPA P (Na H) antiporter COG0589 Cluster_217347 V1242832 NQRB C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG1805 Cluster_405425 V1242833 RNFG S FMN-binding domain-containing protein 12937 Cluster_400049 V1242834 NQRD C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG1347 Cluster_178641 V1242835 C Oxidoreductase FAD-binding domain COG2871 Cluster_471543 V1242836 C Nitroreductase COG0778 Cluster_284506 V1242837 S Membrane COG2966 Cluster_477999 V1242838 S Membrane COG3610 Cluster_84720 V1242839 HUTH map00340,map01100 E Histidine ammonia-lyase COG2986 Cluster_40238 V1242840 HUTU map00340,map01100 E Urocanate hydratase COG2987 Cluster_137486 V1242841 HUTI map00340,map01100 Q imidazolone-5-propionate hydrolase COG1228 Cluster_28069 V1242843 PFLB map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_179511 V1242844 DINB L Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) COG0389 Cluster_288722 V1242845 RSMI G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 Cluster_344152 V1242846 YABB map00340,map00350,map00624,map01120 L Methyltransferase COG4123 Cluster_281729 V1242847 YAAT S psp1 domain protein COG1774 Cluster_292672 V1242848 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit delta' COG2812 Cluster_606924 V1242849 YAAQ S protein from nitrogen regulatory protein P-II COG3870 Cluster_401833 V1242850 TMK map00240,map01100 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) COG0125 Cluster_433014 V1242851 YKOE S ABC superfamily ATP binding cassette transporter membrane protein COG4721 Cluster_121401 V1242852 YKOD map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_377088 V1242853 map02010 P ABC superfamily ATP binding cassette transporter permease protein 0XTSF Cluster_62905 V1242854 DEXB map00052,map00500,map01100 G trehalose-6-phosphate hydrolase (EC 3.2.1.93) COG0366 Cluster_219640 V1242855 map00510,map01100 M GtrA-like protein COG0463 Cluster_770041 V1242856 YYZM S protein, conserved in bacteria COG4481 Cluster_283131 V1242857 MSCS M mechanosensitive ion channel COG0668 Cluster_419760 V1242858 YEDF map04122 S selenium metabolism protein yedf 11NCC Cluster_83399 V1242860 ERIC P Chloride channel COG0038 Cluster_160395 V1242861 MUTT1 L NUDIX hydrolase COG0494 Cluster_58044 V1242862 OADA map00020,map00330,map00620,map00720,map01100,map01120,map01230 C Oxaloacetate decarboxylase COG5016 Cluster_447051 V1242863 S Hdig domain protein COG1418 Cluster_38677 V1242864 FUSA2 J Translation elongation factor COG0480 Cluster_165352 V1242865 ABGA E amidohydrolase COG1473 Cluster_176147 V1242867 YUEF P permease COG0628 Cluster_900720 V1242868 PCKA map00010,map00020,map00620,map00710,map01100,map01110,map01120 C phosphoenolpyruvate carboxykinase 0XT66 Cluster_104608 V1242869 PCKA map00010,map00020,map00620,map00710,map01100,map01110,map01120 C phosphoenolpyruvate carboxykinase 0XT66 Cluster_43137 V1242872 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_316873 V1242873 TATD L Hydrolase, tatD family COG0084 Cluster_451034 V1242874 RNMV L Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) COG1658 Cluster_273734 V1242875 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_625455 V1242876 CZRA K Transcriptional regulator, arsr family COG0640 Cluster_61279 V1242877 map02010 V ABC transporter COG1132 Cluster_112052 V1242878 V MatE COG0534 Cluster_817005 V1242879 RPMB map03010 J 50S ribosomal protein l28 COG0227 Cluster_382373 V1242880 THIN map00730,map01100 H thiamine COG1564 Cluster_378872 V1242881 RPE map00030,map00040,map00710,map01100,map01110,map01120,map01230 G ribulose-phosphate 3-epimerase COG0036 Cluster_273735 V1242882 RSGA G May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) COG1162 Cluster_40711 V1242883 PRKC T serine threonine protein kinase COG0515 Cluster_330511 V1242884 STP T Phosphatase COG0631 Cluster_353756 V1242885 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_487332 V1242886 NUOE map00190,map00910,map01100 C NADH dehydrogenase (Ubiquinone), 24 kDa subunit COG1905 Cluster_78412 V1242887 HYMB map00190,map00910,map01100 C NADH dehydrogenase COG1894 Cluster_82128 V1242888 map00190,map00910,map01100 C hydrogenase) (Fe-only COG4624 Cluster_176148 V1242891 M NA 1DJF1@verNOG Cluster_618008 V1242892 CZRA K Transcriptional regulator, arsr family COG0640 Cluster_327615 V1242893 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_439024 V1242894 RNMV L Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) COG1658 Cluster_318454 V1242895 TATD L Hydrolase, tatD family COG0084 Cluster_41521 V1242896 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_117002 V1242898 GLTS E Sodium Glutamate Symporter COG0786 Cluster_91387 V1242899 ALDA map00010,map00040,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00640,map00903,map01100,map01110,map01120 C Dehydrogenase COG1012 Cluster_336608 V1242900 GLNQ map02010 E abc transporter atp-binding protein COG1126 Cluster_315351 V1242901 GLNP E ABC transporter (Permease) COG0765 Cluster_276420 V1242902 E, T ABC, transporter COG0834 Cluster_211623 V1242903 NTPC map00190,map00680,map01100 C ATP synthase subunit C COG1527 Cluster_353757 V1242904 RIML map00350,map00362,map00627,map00642,map00903,map01120 J acetyltransferase COG1670 Cluster_239897 V1242905 DNAC L DNA replication protein COG1484 Cluster_189897 V1242906 DNAD L DNA replication protein DnaD COG3935 Cluster_414407 V1242907 S Acetyltransferase GNAT Family 124QK Cluster_122840 V1242908 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_520469 V1242909 RPLI map03010 J Binds to the 23S rRNA (By similarity) COG0359 Cluster_129621 V1242910 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_54301 V1242911 TYPA T gtp-binding protein typa COG1217 Cluster_94703 V1242912 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_447052 V1242913 S zinc metalloprotease COG1451 Cluster_83801 V1242915 RLML L Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) COG0116 Cluster_34357 V1242917 L Dna topoisomerase COG0550 Cluster_355424 V1242918 RSMG M Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) COG0357 Cluster_322981 V1242919 SOJ D Chromosome Partitioning Protein COG1192 Cluster_280387 V1242920 PARB K parb-like partition protein COG1475 Cluster_260375 V1242921 PHZF S phenazine biosynthesis protein, phzf family COG0384 Cluster_90917 V1242923 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_197916 V1242924 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_540201 V1242926 S NA 11YG8 Cluster_180341 V1242927 map00270,map01100 L DNA-cytosine methyltransferase COG0270 Cluster_378873 V1242928 S NA 11QRM Cluster_592734 V1242929 map00540,map01100 S Phage-related protein 17GI4@proNOG Cluster_537404 V1242930 S YopX protein 0XUQJ Cluster_45002 V1242932 S NA 0XQBQ Cluster_272403 V1242933 CLOLE_0796 L recT protein COG3723 Cluster_499840 V1242934 LIN1243 S domain protein COG1235 Cluster_345768 V1242935 PURC map00230,map01100,map01110 F SAICAR synthetase COG0152 Cluster_108806 V1242936 PURF map00230,map00250,map01100,map01110 F glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_99497 V1242937 PURB map00230,map00250,map01100,map01110 F Adenylosuccinate lyase COG0015 Cluster_135886 V1242938 PURA map00230,map00250,map01100 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis COG0104 Cluster_252769 V1242940 map00240,map00450 O Pyridine nucleotide-disulphide oxidoreductase COG0492 Cluster_94704 V1242941 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_344153 V1242942 THYX map00240,map00670 F Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) COG1351 Cluster_405426 V1242943 GPMB map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_107062 V1242944 VMRA V Mate efflux family protein COG0534 Cluster_403611 V1242945 UDK map00240,map00710,map00983,map01100,map01120 F uridine monophosphokinase COG0572 Cluster_142780 V1242946 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_147300 V1242947 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_358783 V1242948 S Membrane COG3503 Cluster_256454 V1242949 I May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) COG1597 Cluster_277724 V1242951 DEGV S degv family COG1307 Cluster_445004 V1242952 S Domain of unknown function (DUF1836) 0ZWQ6 Cluster_209414 V1242953 SELU S Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) COG2603 Cluster_135074 V1242954 P Citrate transporter COG1055 Cluster_166892 V1242955 S gtp-binding protein COG3596 Cluster_74188 V1242957 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG2812 Cluster_347359 V1242958 AZLC E azlc family COG1296 Cluster_231291 V1242959 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G phosphohexokinase COG0205 Cluster_59076 V1242960 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG0574 Cluster_520470 V1242961 COMEB map00240,map01100 F deaminase COG2131 Cluster_520471 V1242962 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_83400 V1242963 GLYQS map00970 J Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) COG0423 Cluster_492182 V1242964 CRR map00010,map00500,map00520,map02060 G Pts system COG2190 Cluster_94170 V1242965 CITF map00020,map01110,map02020 C citrate lyase, alpha COG3051 Cluster_269760 V1242966 CITE map00020,map01110,map02020 G HpcH/HpaI aldolase/citrate lyase family COG2301 Cluster_708529 V1242967 CITD map00020,map01110,map02020 C Covalent carrier of the coenzyme of citrate lyase (By similarity) COG3052 Cluster_401834 V1242968 FUMB map00020,map00720,map01100,map01110,map01120 C fumarate COG1838 Cluster_283132 V1242969 FUMA map00020,map00720,map01100,map01110,map01120 C Hydrolyase, Fe-S type, tartrate fumarate subfamily, alpha subunit COG1951 Cluster_156112 V1242970 map00660,map01100 E Methylaspartate ammonia-lyase COG3799 Cluster_534513 V1242972 S NA 0ZCIY Cluster_467266 V1242973 map00830,map00906,map01100,map01110 Q all-trans-retinol 13,14-reductase COG1233 Cluster_44841 V1242974 PULA G Glycogen debranching enzyme COG1523 Cluster_52140 V1242975 G alpha amylase, catalytic COG0366 Cluster_96301 V1242977 S NA 102FF Cluster_148830 V1242978 NLPD M peptidase M23 COG0739 Cluster_174536 V1242979 S Phage portal protein 11N82 Cluster_335078 V1242980 BL00880 map04112 O ATP-dependent Clp protease, proteolytic subunit COG0740 Cluster_160396 V1242981 S Phage capsid family 10CCX Cluster_692219 V1242982 S NA 0Y5Q0 Cluster_629151 V1242983 S NA 0ZAM3 Cluster_7546 V1242984 S s-layer domain-containing protein 11ZJU Cluster_403612 V1242986 SCLAV_4397 S Domain of unknown function (DUF955) 0XUKG Cluster_614255 V1242987 S Beta-lactamase domain protein COG0491 Cluster_277725 V1242988 YLQF K Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) COG1161 Cluster_309309 V1242989 RNHB map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0164 Cluster_724965 V1242990 LICT K antiterminator COG3711 Cluster_718302 V1242991 S NA 0Z9IE Cluster_140526 V1242992 INT S 'Phage' integrase family 0YKE0 Cluster_695988 V1242993 S Cupin 2, conserved barrel domain protein 0ZY40 Cluster_352089 V1242994 YQEC S selenium-dependent hydroxylase accessory protein YqeC 11VFN Cluster_363594 V1242995 S NA 0YY9N Cluster_407094 V1242997 map00561,map01100 G Dihydroxyacetone kinase COG2376 Cluster_347360 V1242998 RSUA J Pseudouridine synthase COG1187 Cluster_123467 V1242999 YWDH map00010,map00040,map00053,map00071,map00280,map00281,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00626,map00640,map00903,map01100,map01110,map01120 C Aldehyde dehydrogenase COG1012 Cluster_408867 V1243000 CPSD M Capsular exopolysaccharide family COG0489 Cluster_310750 V1243001 G, M Inherit from COG: Capsular polysaccharide biosynthesis protein COG4464 Cluster_243902 V1243002 OPPB map02010 P ABC transporter (Permease COG0601 Cluster_242546 V1243003 OPPC map02010 P abc transporter, permease COG1173 Cluster_205062 V1243004 OPPD map02010 E, P ABC transporter COG0444 Cluster_316874 V1243005 TATD L Hydrolase, tatD family COG0084 Cluster_456941 V1243006 RNMV L Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) COG1658 Cluster_277726 V1243007 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_113512 V1243008 MGTE P magnesium transporter COG2239 Cluster_836256 V1243009 S isoprenylcysteine carboxyl methyltransferase family protein 0ZWP8 Cluster_136698 V1243010 S Inherit from COG: ATPase (AAA COG1373 Cluster_210491 V1243011 S NA 11SAZ Cluster_21310 V1243012 Y0750 S Conserved Protein COG1479 Cluster_183815 V1243014 MANC map00051,map00520,map01100,map01110 M Mannose-1-phosphate guanylyltransferase COG0836 Cluster_563815 V1243015 HIT F, G Histidine triad (HIT) protein COG0537 Cluster_268423 V1243016 SUCD map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120 C Succinyl-CoA ligase ADP-forming subunit alpha COG0074 Cluster_171160 V1243017 SUCC map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120 C Succinyl-CoA synthetase subunit beta COG0045 Cluster_238626 V1243018 S Filamentation induced by cAMP protein fic 11MJJ Cluster_197917 V1243019 RHAT7 E, G Transporter COG0697 Cluster_425218 V1243020 ARSM map00130,map00340,map00350,map00624,map01100,map01110,map01120 S methyltransferase, type 11 0XSKB Cluster_63467 V1243021 NIST map02010 V ABC transporter 0XPIZ Cluster_196982 V1243026 S integral membrane protein COG0392 Cluster_59349 V1243027 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_429035 V1243028 AHPC O Peroxiredoxin COG0450 Cluster_80587 V1243029 O Alkyl hydroperoxide reductase F subunit COG3634 Cluster_358784 V1243030 PPIA O PPIases accelerate the folding of proteins COG0652 Cluster_34358 V1243031 S TPR repeat-containing protein COG0457 Cluster_3863 V1243033 DPNA L helicase COG4646 Cluster_362024 V1243036 PHOB map02020 T Two component transcriptional regulator, winged helix family COG0745 Cluster_391176 V1243037 PHOU P Plays a role in the regulation of phosphate uptake COG0704 Cluster_322982 V1243038 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_264364 V1243039 PSTA map02010 P phosphate abc transporter COG0581 Cluster_249075 V1243040 PSTC map02010 P phosphate abc transporter COG0573 Cluster_83802 V1243043 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_400050 V1243044 PURN map00230,map00670,map01100,map01110 F phosphoribosylglycinamide formyltransferase COG0299 Cluster_200901 V1243045 PURM map00230,map01100,map01110 F phosphoribosylaminoimidazole synthetase COG0150 Cluster_489683 V1243046 PURE map00230,map01100,map01110 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) COG0041 Cluster_237308 V1243047 MSRA O reductase COG0229 Cluster_251547 V1243048 E, G EamA-like transporter family COG0697 Cluster_39632 V1243049 PULA map00500,map01100,map01110 G Glycogen debranching enzyme COG1523 Cluster_53051 V1243054 S Pfam:LACT 0ZI03 Cluster_2204 V1243056 S NA 0YG6V Cluster_150462 V1243057 HSDS V restriction COG0732 Cluster_219641 V1243058 L recombinase (Phage integrase family) COG0582 Cluster_347361 V1243059 NRDG O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) COG0602 Cluster_621658 V1243060 S macrophage migration inhibitory factor 0ZX29 Cluster_434930 V1243061 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_77822 V1243062 HSDM V type I restriction-modification system COG0286 Cluster_708530 V1243064 S NA 11QY9 Cluster_118406 V1243065 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2801 Cluster_560830 V1243066 GRDX S grdx protein 1230X Cluster_239898 V1243067 WHIA K May be required for sporulation (By similarity) COG1481 Cluster_540202 V1243068 CG3417 map00230,map00240 L nudix hydrolase COG0494 Cluster_347362 V1243070 S NA 11NB4 Cluster_44101 V1243071 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_355425 V1243072 LRGB map02020 M lrgb family COG1346 Cluster_618009 V1243073 LRGA map02020 S lrga family COG1380 Cluster_226640 V1243074 ETFA map00910 C Electron transfer flavoprotein COG2025 Cluster_316875 V1243075 ETFB map00910 C Electron transfer flavoprotein COG2086 Cluster_172898 V1243076 ACDA2 map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I acyl-CoA dehydrogenase COG1960 Cluster_260376 V1243078 YAAT S psp1 domain protein COG1774 Cluster_384140 V1243079 FUCA map00051 G Class II aldolase adducin family protein COG0235 Cluster_195312 V1243080 MTNA map00270,map01100 J Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) COG0182 Cluster_423419 V1243082 YEDF map04122 S selenium metabolism protein yedf 11NCC Cluster_785323 V1243083 S Protein of unknown function (DUF3343) 0ZZRX Cluster_801023 V1243084 YYZM S protein, conserved in bacteria COG4481 Cluster_205063 V1243085 SUA J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0009 Cluster_391177 V1243086 UPP map00240,map01100 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) COG0035 Cluster_46144 V1243087 NTPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_755069 V1243088 ATPE map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) 0ZX7S Cluster_82548 V1243089 G domain protein 11V8D Cluster_201893 V1243090 HYDE map00780,map01100 H radical SAM domain protein COG0502 Cluster_100570 V1243091 HYDG map00730,map01100 H biosynthesis protein thiH COG1060 Cluster_167692 V1243092 HYDF S gtp-binding protein COG1160 Cluster_134286 V1243093 M Alpha beta hydrolase fold COG1073 Cluster_168543 V1243094 M peptidase M23 COG0739 Cluster_517906 V1243095 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_133491 V1243096 CITG map02020 H triphosphoribosyl-dephospho-CoA synthase COG3697 Cluster_163705 V1243097 MVAD map00900,map01100,map01110 I diphosphomevalonate decarboxylase COG3407 Cluster_165353 V1243098 map02010 V ABC-2 type transporter COG0842 Cluster_167693 V1243099 map02010 V ABC-2 type transporter COG0842 Cluster_83803 V1243100 FIXA V ABC transporter, ATP-binding protein COG1131 Cluster_592736 V1243103 M peptidase M23 0XQC5 Cluster_566998 V1243104 C Alcohol dehydrogenase zinc-binding domain protein COG1063 Cluster_423420 V1243105 P Chromate COG2059 Cluster_394817 V1243106 P Chromate COG2059 Cluster_566999 V1243107 S NA 0YX61 Cluster_633001 V1243108 S NA 12BEE Cluster_625457 V1243112 CKL_1885 S Protein of unknown function (DUF1064) 1251H Cluster_287360 V1243113 LIN1244 S DnaD domain protein 11TF8 Cluster_445005 V1243114 BET L Phage recombination protein Bet 11G2M Cluster_497173 V1243115 S Gp157 family 11ZXY Cluster_2105 V1243119 S NA 101UU Cluster_715061 V1243121 ETFB map00910 C Electron transfer flavoprotein COG2086 Cluster_275090 V1243122 FABI map00061,map00780,map01100 I Enoyl- acyl-carrier-protein reductase NADH COG0623 Cluster_526141 V1243123 SP_1786 S Toxin-antitoxin system, antitoxin component, HicB family COG1598 Cluster_482723 V1243124 RLMH S Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) COG1576 Cluster_148831 V1243125 CAPA M Capsule synthesis protein COG2843 Cluster_188191 V1243126 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_517907 V1243127 S NA 11QKP Cluster_560831 V1243128 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_208371 V1243130 PFOR S Membrane COG3641 Cluster_375322 V1243131 YQFA S hemolysin iii COG1272 Cluster_265696 V1243133 S NA 0YY2Z Cluster_119137 V1243134 GDHA map00250,map00330,map00910,map01100 E Glutamate dehydrogenase COG0334 Cluster_327616 V1243136 S rdd domain containing protein COG1714 Cluster_751601 V1243137 MT3796 S integral membrane protein COG1300 Cluster_47116 V1243138 S NA 129FA Cluster_242547 V1243139 S NA 0XQ5H Cluster_200902 V1243140 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_313768 V1243142 YJFP S Esterase COG1073 Cluster_273736 V1243143 PAP L polyphosphate kinase 2 COG2326 Cluster_855646 V1243144 RUBR C rubredoxin COG1773 Cluster_570083 V1243145 T anti-sigma regulatory factor serine threonine protein kinase 11VVV Cluster_108193 V1243146 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_573282 V1243147 S Pfam:DUF1200 0YA60 Cluster_445006 V1243148 L Integrase 0YTFQ Cluster_454999 V1243149 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_250328 V1243150 S CAAX protease self-immunity 0XUJM Cluster_332068 V1243151 NPDA map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_333577 V1243152 Q Methyltransferase Type COG0500 Cluster_734776 V1243153 YEFM S prevent-host-death family 12675 Cluster_724967 V1243154 YOEB S Addiction module toxin, Txe YoeB family COG4115 Cluster_247756 V1243155 HSLO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) COG1281 Cluster_104009 V1243156 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_182095 V1243159 THIL map00730,map01100 H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) COG0611 Cluster_171161 V1243160 S Ser Thr phosphatase family protein COG1408 Cluster_118407 V1243161 DINF V Mate efflux family protein COG0534 Cluster_56767 V1243162 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_347363 V1243163 YGDL H uba thif-type nad fad binding protein COG1179 Cluster_534514 V1243164 T Positive regulator of sigma(E), RseC/MucC 0ZZM5 Cluster_144229 V1243165 GLYA map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01230 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) COG0112 Cluster_382374 V1243166 S Membrane COG3601 Cluster_31742 V1243168 MDH map00620,map00710,map01100,map01120,map02020 C malate dehydrogenase (Oxaloacetate-decarboxylating) COG0281 Cluster_237309 V1243169 HPRA map00260,map00630,map00680,map01100,map01110,map01120 C Dehydrogenase COG1052 Cluster_439025 V1243170 map00350,map00362,map00627,map00642,map00903,map01120 K acetyltransferase COG0454 Cluster_122166 V1243171 map00051,map00363,map00520,map00591,map00625,map00650,map01100,map01120 M Dehydrogenase COG0677 Cluster_208372 V1243172 WLBA map00520 S domain protein COG0673 Cluster_232459 V1243173 HADH map00360,map00362,map00650,map01100,map01120 C Dehydrogenase COG1250 Cluster_42218 V1243174 HPPA map00190 C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for COG3808 Cluster_414408 V1243176 S Metal Dependent Phosphohydrolase COG2316 Cluster_208373 V1243177 GAP map00010,map01100,map01110,map01120,map01230,map04066,map05010 G glyceraldehyde-3-phosphate dehydrogenase COG0057 Cluster_183816 V1243178 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_91872 V1243179 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_206150 V1243180 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_357115 V1243181 TPIS map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_451035 V1243182 MDAB S modulator of drug activity COG2249 Cluster_128906 V1243184 THIC map00730,map01100 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) COG0422 Cluster_447053 V1243185 APT map00230,map01100 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) COG0503 Cluster_101703 V1243186 NHAC map00680 C Na H antiporter COG1757 Cluster_322983 V1243187 NIRC P nitrite transporter COG2116 Cluster_291312 V1243188 S tigr02206 127PX Cluster_188192 V1243189 AGUA map00330,map01100 E Agmatine deiminase COG2957 Cluster_262985 V1243190 AGUB map00330,map01100 S hydrolase, carbon-nitrogen family COG0388 Cluster_272404 V1243191 S NA 0YYM2 Cluster_171162 V1243192 GALM map00010,map01110,map01120 G converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) COG2017 Cluster_51926 V1243194 S NA 0YKBK Cluster_142002 V1243195 HFLX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COG2262 Cluster_108194 V1243196 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_182096 V1243197 CLOSA_0730 V Hnh endonuclease COG1479 Cluster_226641 V1243198 ECORIM L Modification methylase EcoRI 0XPU0 Cluster_170341 V1243201 L Integrase COG0582 Cluster_367049 V1243203 SDAAB map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase, iron-sulfur-dependent, beta subunit COG1760 Cluster_268424 V1243204 SDAA map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase COG1760 Cluster_375323 V1243205 PPAX map00190,map00230,map00240,map00630,map00760,map01100,map01110 S Hydrolase COG0546 Cluster_633002 V1243206 YHEA S UPF0342 protein COG3679 Cluster_241175 V1243207 K protein containing TIR-like COG4271 Cluster_209415 V1243208 S peptidase m28 0ZVCD Cluster_51329 V1243209 J Glutamine amidotransferase COG2355 Cluster_502373 V1243210 ASNC K regulatory protein, asnc COG1522 Cluster_264365 V1243211 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_208374 V1243212 FABH map00061,map01100 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) COG0332 Cluster_460974 V1243213 S Uncharacterized ACR, COG1399 11J4F Cluster_205064 V1243214 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_121402 V1243215 ARCT map00300,map00480,map01100,map01120,map01230 E Dipeptidase COG0624 Cluster_210492 V1243216 map00051 M Glycosyl transferase, family 2 COG0463 Cluster_55503 V1243217 S NA 0YDZN Cluster_186493 V1243218 YCHF J gtp-binding protein COG0012 Cluster_283133 V1243219 S ABC transporter COG1277 Cluster_458923 V1243220 K RNA polymerase COG1595 Cluster_665625 V1243221 S NA 0ZUR0 Cluster_751602 V1243222 YABO J s4 domain protein COG1188 Cluster_579621 V1243223 DIVIC S septum formation initiator 0XUCI Cluster_586059 V1243224 YABR J RNA binding s1 domain protein COG1098 Cluster_121403 V1243225 TILS D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) COG0037 Cluster_451036 V1243226 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_43708 V1243227 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_345769 V1243228 map00730,map01100 H IA, variant 3 COG0637 Cluster_147301 V1243229 FPRA C domain protein COG0426 Cluster_292673 V1243230 TTCA D Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) COG0037 Cluster_96302 V1243231 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_271069 V1243232 C radical SAM domain protein COG1032 Cluster_135887 V1243233 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_443016 V1243234 S tm2 domain 11XDS Cluster_280388 V1243235 S Protein of unknown function (DUF975) COG5523 Cluster_171163 V1243236 TGT J Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COG0343 Cluster_718303 V1243237 SP_0207 map00240,map00983,map01100 S phosphoribulokinase uridine kinase 11JPM Cluster_200903 V1243238 M Sortase family COG3764 Cluster_124105 V1243239 YOCR P Transporter COG0733 Cluster_269761 V1243240 map00260,map00670,map00910,map01100 E Aminomethyltransferase folate-binding domain 0YP69 Cluster_378874 V1243241 map00770,map01100 H Pantothenate kinase 109YT Cluster_455000 V1243242 YBBC V conserved protein UCP016719 COG3876 Cluster_657202 V1243243 YUTD S transcriptional regulator COG4470 Cluster_188193 V1243244 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_452981 V1243245 VANZ V VanZ-like protein COG4767 Cluster_373611 V1243246 PILD N, O, U Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) COG1989 Cluster_391178 V1243247 DPS P DNA protection during starvation protein COG0783 Cluster_217348 V1243248 ETFA map00910 C Electron transfer flavoprotein COG2025 Cluster_302240 V1243249 ETFB map00910 C Electron transfer flavoprotein COG2086 Cluster_165354 V1243250 P Inherit from COG: Periplasmic binding protein COG0614 Cluster_205065 V1243251 FECD map02010 P abc transporter COG0609 Cluster_358785 V1243252 map02010 P Abc transporter COG1120 Cluster_212712 V1243254 S Beta-lactamase domain protein COG0491 Cluster_225520 V1243255 FOLP map00790,map01100 H dihydropteroate synthase COG0294 Cluster_344154 V1243256 GRAR T response regulator COG0745 Cluster_231292 V1243257 HPRK T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) COG1493 Cluster_6062 V1243258 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_22528 V1243259 P tonB-dependent Receptor 1002P Cluster_169475 V1243260 S NA 11I3U Cluster_695989 V1243261 HSDM V type I restriction-modification system COG0286 Cluster_178643 V1243262 METE map00270,map00450,map01100,map01110,map01230 E Methionine synthase COG0620 Cluster_284507 V1243263 METQ map02010 P lipoprotein COG1464 Cluster_375324 V1243264 METN map02010 P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COG1135 Cluster_112053 V1243266 V HNH endonuclease COG1403 Cluster_441013 V1243270 S (LipO)protein 0XSYT Cluster_27273 V1243271 S Inherit from NOG: surface antigen 0XQ7Y Cluster_339579 V1243272 HYDROLASE S Hydrolase COG1011 Cluster_502374 V1243273 NRDG S (Anaerobic) ribonucleoside-triphosphate reductase activating protein 11SJF Cluster_164500 V1243274 SPL M NlpC/P60 family COG0791 Cluster_563816 V1243275 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_119902 V1243276 DGT map00230 F deoxyguanosinetriphosphate triphosphohydrolase-like protein COG0232 Cluster_217349 V1243277 S 5 nucleotidase deoxy cytosolic type C 11SZB Cluster_357116 V1243278 REX K Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) COG2344 Cluster_49164 V1243279 UUP S Abc transporter COG0488 Cluster_389447 V1243280 V ABC, transporter COG1136 Cluster_315352 V1243281 YBBM S ABC transporter, permease COG0390 Cluster_439026 V1243282 S NA 120PT Cluster_5488 V1243283 S Glucan-binding protein C 1001J Cluster_621659 V1243284 S domain protein 11NZ4 Cluster_259072 V1243285 ALKA map03410 L 8-oxoguanine DNA glycosylase COG0122 Cluster_130353 V1243286 GLUD map00250,map00330,map00430,map00471,map00910,map01100,map04964 E Glutamate dehydrogenase COG0334 Cluster_104609 V1243287 GLYQS map00970 J Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) COG0423 Cluster_805220 V1243288 PRFA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) COG0216 Cluster_291313 V1243289 S nlpC P60 family protein 0ZVM8 Cluster_75170 V1243290 PORX T response regulator 0Y6W0 Cluster_546054 V1243291 YJEE S protein family UPF0079, ATPase COG0802 Cluster_230115 V1243292 MANA map00051,map00520,map01100,map01110 G mannose-6-phosphate isomerase COG1482 Cluster_480404 V1243293 H Molybdenum cofactor synthesis domain protein COG0303 Cluster_238627 V1243294 BL02952 S Membrane COG1434 Cluster_734777 V1243295 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E brancheD-chain amino acid aminotransferase COG0115 Cluster_171164 V1243296 APBE H ApbE family COG1477 Cluster_471544 V1243297 S NA 0Z1V8 Cluster_471545 V1243298 PGPA map00564,map01100 I phosphatidylglycerophosphatase a COG1267 Cluster_382375 V1243299 T cyclic nucleotide-binding domain protein COG0664 Cluster_762377 V1243300 S Pfam:Complex1_24kDa 0XVAK Cluster_504777 V1243301 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_758588 V1243302 M Glycosyl transferase, family 2 COG0463 Cluster_259073 V1243303 PHZF S phenazine biosynthesis protein, phzf family COG0384 Cluster_284508 V1243304 PARB K parb-like partition protein COG1475 Cluster_315353 V1243305 SOJ D Chromosome Partitioning Protein COG1192 Cluster_350590 V1243306 RSMG M Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) COG0357 Cluster_300863 V1243307 S Calcineurin-like phosphoesterase COG1408 Cluster_171982 V1243308 GLGD map00500,map00520,map01100,map01110 M glucose-1-phosphate adenylyltransferase, glgd subunit COG0448 Cluster_171165 V1243309 GLGC map00500,map00520,map01100,map01110 G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) COG0448 Cluster_48078 V1243310 GLGB map00500,map01100,map01110 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) COG0296 Cluster_300864 V1243311 S Protein of unknown function (DUF2785) 123P8 Cluster_731565 V1243312 YDZF K Transcriptional regulator COG1733 Cluster_699272 V1243313 S NA 11UTV Cluster_13626 V1243314 PACL P cation-transporting atpase COG0474 Cluster_316876 V1243315 S haloacid dehalogenase-like hydrolase COG0637 Cluster_62380 V1243316 M Glycosyl hydrolase, family 25 COG3757 Cluster_256455 V1243317 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_83804 V1243318 GEOTH_0480 L Integrase catalytic subunit COG4584 Cluster_309310 V1243319 EBA2484 L AtP-binding protein COG1484 Cluster_303691 V1243321 S relaxase mobilization nuclease domain protein 0XNXG Cluster_629152 V1243323 S NA 127P0 Cluster_382376 V1243325 S Abortive infection protein AbiGII 0XQHH Cluster_138250 V1243326 ATOB map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map02020 I acetyl-coa acetyltransferase COG0183 Cluster_114222 V1243327 MVAA map00900,map01100,map01110,map04976 I hydroxymethylglutaryL-CoA reductase COG1257 Cluster_50577 V1243328 PRKC T serine threonine protein kinase COG2815 Cluster_330512 V1243329 STP T phosphatase COG0631 Cluster_124106 V1243330 SUN J ribosomal RNA small subunit methyltransferase b COG0144 Cluster_189898 V1243331 CARA map00240,map00250,map01100 F carbamoyl-phosphate synthetase glutamine chain COG0505 Cluster_674302 V1243332 YBXF map03010 J ribosomal protein COG1358 Cluster_540203 V1243333 RPSL map03010 J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) COG0048 Cluster_497174 V1243334 RPSG map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) COG0049 Cluster_38839 V1243335 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_156967 V1243336 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_47700 V1243337 SILP P copper-exporting ATPase COG2217 Cluster_431017 V1243339 K Transcriptional regulator, ARAC family 11PBK Cluster_91388 V1243340 NORM V MATE efflux family protein COG0534 Cluster_482724 V1243341 MSCS M mechanosensitive ion channel COG0668 Cluster_118408 V1243343 GDHA map00250,map00330,map00910,map01100 E Glutamate dehydrogenase COG0334 Cluster_241176 V1243344 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate (By similarity) COG0167 Cluster_241177 V1243345 MSRA O reductase COG0229 Cluster_494664 V1243346 GREA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) COG0782 Cluster_467268 V1243347 S NA 0XU7T Cluster_648991 V1243348 map00350,map00362,map00627,map00642,map00903,map01120 S acetyltransferase, (GNAT) family COG3981 Cluster_82129 V1243350 M Inherit from COG: choline binding protein COG4990 Cluster_35836 V1243351 F ATP cone domain COG1328 Cluster_162061 V1243352 CTPA M Carboxyl-terminal protease COG0793 Cluster_687722 V1243353 RAIA S ribosomal subunit Interface protein 124EG Cluster_262986 V1243354 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_817006 V1243355 RPSU map03010 J 30S ribosomal protein S21 122SW Cluster_633003 V1243356 S tm2 domain 127T8 Cluster_661414 V1243357 S interferon-induced transmembrane protein 121MN Cluster_326062 V1243359 S NA 11G6R Cluster_104610 V1243360 XC_0137 L transposase COG3039 Cluster_797089 V1243361 S helix-turn-helix domain protein 122WR Cluster_10361 V1243363 M domain protein 0ZWTG Cluster_275091 V1243364 S NA 0XWFB Cluster_384141 V1243365 PCP O Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) COG2039 Cluster_436990 V1243366 K Transcriptional regulator, TetR family 11S7S Cluster_368659 V1243367 S NA 0XS0Q Cluster_546055 V1243368 S Membrane 12424 Cluster_296805 V1243369 S NA 0YCKF Cluster_396591 V1243370 DCK map00230,map00240,map01100 F deoxynucleoside kinase COG1428 Cluster_400051 V1243371 DCK map00230,map00240,map01100 F deoxynucleoside kinase COG1428 Cluster_94171 V1243372 PAFA S type i phosphodiesterase nucleotide pyrophosphatase COG1524 Cluster_148832 V1243374 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_781214 V1243375 S Hydrid cluster protein-associated redox disulfide domain protein 123UM Cluster_252770 V1243376 S NA 0XWFB Cluster_233717 V1243377 S Transporter, auxin efflux carrier (AEC) family protein COG0679 Cluster_9848 V1243378 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_85544 V1243379 S Ragb susd domain-containing protein 0XPXH Cluster_215018 V1243380 MANX map00051,map00520,map01100,map02060 G pts system COG3444 Cluster_731566 V1243381 RPMA map03010 J 50S ribosomal protein l27 COG0211 Cluster_112054 V1243382 TIG O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COG0544 Cluster_777463 V1243383 S Conserved domain protein COG4443 Cluster_64846 V1243384 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_219642 V1243385 YEIH S Membrane COG2855 Cluster_24918 V1243387 P tonB-dependent Receptor 0XP5Y Cluster_482725 V1243388 map00620,map04011 S Glyoxalase Bleomycin resistance protein (Dioxygenase 0XUYC Cluster_163706 V1243389 CTPA M Carboxyl-terminal protease COG0793 Cluster_150463 V1243390 NLPD M peptidase M23 COG0739 Cluster_246500 V1243391 FTSX map02010 D Part of the ABC transporter FtsEX involved in COG2177 Cluster_352090 V1243392 FTSE map02010 D Cell division ATP-binding protein ftsE COG2884 Cluster_22439 V1243394 RECG map03440 L ATP-dependent DNA helicase RecG COG1200 Cluster_365337 V1243395 S domain protein 0XQK0 Cluster_492183 V1243396 RIBH map00740,map01100 H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) COG0054 Cluster_938516 V1243399 S Conserved Protein COG3543 Cluster_129622 V1243400 YQEV J MiaB-like tRNA modifying enzyme COG0621 Cluster_357117 V1243401 RSME S Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) COG1385 Cluster_254015 V1243402 PRMA J Methylates ribosomal protein L11 (By similarity) COG2264 Cluster_174537 V1243403 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_460975 V1243404 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_480405 V1243405 S Hypothetical bacterial integral membrane protein (Trep_Strep) 11MJD Cluster_300865 V1243406 BMUL_0586 map00051,map00520,map01100,map01110 M Nucleotidyl transferase COG1208 Cluster_83012 V1243407 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_582869 V1243408 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_208375 V1243409 GAPA map00010,map01100,map01110,map01120,map01230,map04066,map05010 G Glyceraldehyde-3-phosphate dehydrogenase, type I COG0057 Cluster_67529 V1243410 YJJK S ABC transporter, ATP-binding protein COG0488 Cluster_94172 V1243412 YCAM E amino acid COG0531 Cluster_124759 V1243413 APEB E M18 family aminopeptidase COG1362 Cluster_215019 V1243414 K AraC Family Transcriptional Regulator COG2207 Cluster_606925 V1243416 S NA 12481 Cluster_271070 V1243417 T Histidine kinase 11IN2 Cluster_321421 V1243418 map02010 S NA 125DR Cluster_70546 V1243420 CYDC map02010 V ABC transporter, ATP-binding protein COG1132 Cluster_62381 V1243421 CYDD map02010 V ABC, transporter COG4988 Cluster_429036 V1243422 EFP J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) COG0231 Cluster_310751 V1243423 map00473,map00550,map01100 S Pasta domain containing protein 120IY Cluster_186494 V1243424 RLUD J Pseudouridine synthase COG0564 Cluster_217350 V1243425 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_789340 V1243426 S Acyl-transferase 0XPHK Cluster_20082 V1243427 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_55758 V1243428 G domain protein 11V8D Cluster_269762 V1243429 M Glycosyl transferase, family 2 COG1216 Cluster_128192 V1243430 S glycosyltransferase 10UYG Cluster_284509 V1243432 map00052,map00520,map01100,map01110 M Male sterility protein COG0451 Cluster_543101 V1243433 S DNA-binding protein with PD1-like DNA-binding motif COG1661 Cluster_119903 V1243434 V Mate efflux family protein COG0534 Cluster_401835 V1243435 RBR C Rubrerythrin COG1592 Cluster_259074 V1243436 S YitT family COG1284 Cluster_226642 V1243437 NUDF map00230 F nudix hydrolase COG0494 Cluster_27970 V1243439 S NA 0ZSEH Cluster_492184 V1243440 S NA 0YEGC Cluster_207246 V1243441 REP L Replication Protein COG5527 Cluster_731567 V1243442 GLNQ E abc transporter atp-binding protein COG1126 Cluster_480406 V1243443 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_33246 V1243444 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_309311 V1243445 S NA 11JB6 Cluster_439027 V1243446 RFBC map00521,map00523,map01100,map01110 M Dtdp-4-dehydrorhamnose 3,5-epimerase COG1898 Cluster_3068 V1243447 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG4412 Cluster_318455 V1243448 Q abc transporter atp-binding protein COG1127 Cluster_327617 V1243450 YRBE Q ABC superfamily ATP binding cassette transporter permease protein COG0767 Cluster_284510 V1243451 LPTB map02010 S ABC transporter COG1137 Cluster_197919 V1243452 EXOH S Succinoglycan biosynthesis protein 11X4W Cluster_97362 V1243454 CVRA P Participates in control of cell volume in low-osmolarity conditions (By similarity) COG3263 Cluster_5768 V1243455 M Cell surface protein 11GRZ Cluster_678749 V1243456 P Rhodanese-like domain COG0607 Cluster_225521 V1243457 YOCR P Transporter COG0733 Cluster_648992 V1243458 S NA 0ZCH5 Cluster_191674 V1243459 PLDB map00564 I alpha beta COG2267 Cluster_161222 V1243460 PERMEASE S permease COG0701 Cluster_362025 V1243461 SUA5 J sua5 ycio yrdc ywlc family protein COG0009 Cluster_247757 V1243462 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_226643 V1243463 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_62906 V1243464 PRKC T serine threonine protein kinase COG0515 Cluster_332069 V1243465 STP T Phosphatase COG0631 Cluster_197920 V1243466 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_692221 V1243467 S toxin-antitoxin system, antitoxin component, ribbon-helix-helix 11U5W Cluster_384142 V1243468 S NA 0YSBG Cluster_347364 V1243469 map00230 S Metal Dependent Phosphohydrolase 11UWJ Cluster_718304 V1243470 S NA 0ZXSV Cluster_246501 V1243471 YCXC E, G Transporter COG0697 Cluster_69267 V1243473 U TraG family COG3505 Cluster_319942 V1243474 MIDI_00056 L Transposase 0YEAS Cluster_131903 V1243475 S Inherit from COG: ATPase (AAA COG1373 Cluster_360450 V1243477 S NA 0YC0Y Cluster_5361 V1243478 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_96823 V1243479 D Maf-like protein COG0424 Cluster_310752 V1243480 PGN_0947 S outer membrane lipoprotein-sorting protein 0XQME Cluster_166163 V1243481 CZCB P Efflux transporter rnd family, mfp subunit 0XR5J Cluster_48766 V1243483 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_146525 V1243484 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_37020 V1243485 PULA G Glycogen debranching enzyme COG1523 Cluster_220832 V1243486 MALR map00473,map01100 K transcriptional regulator COG1609 Cluster_439028 V1243487 SP_1232 S Membrane COG4684 Cluster_256456 V1243488 SDAAA map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase COG1760 Cluster_371996 V1243489 SDAAB map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase, iron-sulfur-dependent, beta subunit COG1760 Cluster_265697 V1243490 K Phage antirepressor protein KilAC domain COG3645 Cluster_382377 V1243491 K peptidase s24 s26a s26b, conserved region 0XUC3 Cluster_295461 V1243492 DIND S DNA-damage-inducible protein d 0XQQP Cluster_721619 V1243493 S NA 126GF Cluster_53052 V1243494 S NA 11YT1 Cluster_36691 V1243495 PEP E prolyl oligopeptidase COG1505 Cluster_69268 V1243496 FADD map00071,map01100,map03320,map04146,map04920 I AMP-binding enzyme COG1022 Cluster_755073 V1243497 YLZA S UPF0296 protein COG2052 Cluster_264366 V1243498 YICC map03010 S YicC domain protein COG1561 Cluster_64025 V1243499 FBPA K Fibronectin-binding protein COG1293 Cluster_250329 V1243500 RLUD J Pseudouridine synthase COG0564 Cluster_21078 V1243501 M exopolysaccharide biosynthesis COG0489 Cluster_551975 V1243503 S HIRAN domain 0XVUM Cluster_382378 V1243506 S septicolysin 11TVT Cluster_421557 V1243510 RUVC map03440 L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) COG0817 Cluster_367050 V1243511 S Metallo-Beta-Lactamase 10GCR Cluster_394818 V1243512 RSMG M Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) COG0357 Cluster_318456 V1243513 S Protein of unknown function (DUF3298) 11R45 Cluster_358786 V1243514 FAT map00061,map01100 I Acyl-ACP thioesterase COG3884 Cluster_149594 V1243515 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_199907 V1243516 E peptidase 0XRNU Cluster_480407 V1243517 LRP K transcriptional regulator, AsnC family COG1522 Cluster_54034 V1243518 LIPA map00785,map01100 H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) COG0320 Cluster_520473 V1243521 SP_1783 L Nudix family COG0494 Cluster_136699 V1243522 RARA L recombination factor protein RarA COG2256 Cluster_55504 V1243524 S Toprim domain protein 0ZC02 Cluster_299480 V1243525 S Calcineurin-like phosphoesterase COG1408 Cluster_166893 V1243526 PFK map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G K00850 6-phosphofructokinase 1 EC 2.7.1.11 COG0205 Cluster_65698 V1243528 M Inherit from COG: YD repeat protein COG3209 Cluster_188194 V1243530 VANS T Histidine kinase COG0642 Cluster_344155 V1243531 VANR T response regulator COG0745 Cluster_363595 V1243532 P abc transporter atp-binding protein COG1117 Cluster_335079 V1243533 map02010 P ABC transporter, permease COG0581 Cluster_271071 V1243534 PSTC map02010 P phosphate abc transporter COG0573 Cluster_678750 V1243535 map00010,map00500 G glycoside hydrolase family 4 COG1486 Cluster_896407 V1243536 YBHL S Membrane COG0670 Cluster_431018 V1243537 ZUPT P Mediates zinc uptake. May also transport other divalent cations (By similarity) COG0428 Cluster_487333 V1243538 YBAK S YbaK ebsC protein COG2606 Cluster_170342 V1243539 IADA S Isoaspartyl dipeptidase 0XNTK Cluster_265698 V1243540 ASNA2 map00250,map00460,map00511,map00910,map01100,map01110,map04142 E asparaginase COG1446 Cluster_341042 V1243541 ISPD map00900,map01100,map01110 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COG1211 Cluster_492185 V1243542 ISPF map00900,map01100,map01110 I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) COG0245 Cluster_377089 V1243543 TAL map00030,map01100,map01110,map01120,map01230 G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) COG0176 Cluster_228948 V1243544 GLPX map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120 G Fructose-1,6-bisphosphatase COG1494 Cluster_110748 V1243545 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_279085 V1243546 FTSQ map04112 S cell division protein 11KRI Cluster_28768 V1243547 G domain protein 11V8D Cluster_398316 V1243548 ENGB S Necessary for normal cell division and for the maintenance of normal septation (By similarity) COG0218 Cluster_51527 V1243549 TYPA T gtp-binding protein typa COG1217 Cluster_60658 V1243550 V ABC transporter COG1132 Cluster_92368 V1243551 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_471546 V1243552 S NA 121S9 Cluster_540204 V1243554 LGAS_0623 S phage protein 1218T Cluster_181165 V1243555 XKDT S baseplate J family protein COG3299 Cluster_290005 V1243556 LGAS_0625 S Uncharacterized protein conserved in bacteria (DUF2313) 127C4 Cluster_621660 V1243558 RPLS map03010 J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) COG0335 Cluster_283134 V1243559 YLQF K Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) COG1161 Cluster_478001 V1243560 RNHB map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0164 Cluster_586060 V1243561 L UPF0102 protein COG0792 Cluster_85119 V1243562 COMM O Mg chelatase subunit ChlI COG0606 Cluster_471547 V1243563 CBIO map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_412528 V1243564 CYSG map00860,map01100,map01110 H Siroheme synthase COG1648 Cluster_260377 V1243565 HEMC map00860,map01100,map01110 H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) COG0181 Cluster_92369 V1243566 COBA map00860,map01100,map01110 H Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) COG1587 Cluster_232460 V1243567 HEMB map00860,map01100,map01110 H delta-aminolevulinic acid dehydratase COG0113 Cluster_563817 V1243568 SECG map03060,map03070 U Preprotein translocase SecG subunit 123GJ Cluster_306581 V1243569 S NA 11PBC Cluster_141278 V1243570 K Transcriptional regulator COG3604 Cluster_212713 V1243571 S Uncharacterised protein family (UPF0104) 10F01 Cluster_492186 V1243572 map00051,map00520,map01100 M RmlD substrate binding domain COG1089 Cluster_116302 V1243573 GATC2 map00052,map01100,map02060 G PTS system, galactitol-specific IIc component COG3775 Cluster_324565 V1243574 K transcriptional regulator DeoR family COG1349 Cluster_497175 V1243575 S NA 0Y3MC Cluster_63183 V1243576 ACD map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I Acyl-coa dehydrogenase COG1960 Cluster_207247 V1243577 ETFA map00910 C Electron transfer flavoprotein COG2025 Cluster_16939 V1243578 P ATPase, P-type transporting, HAD superfamily, subfamily IC COG0474 Cluster_582870 V1243579 K TRANSCRIPTIONAl REGULATOR GntR family COG1725 Cluster_283135 V1243580 V ABC transporter COG1131 Cluster_33526 V1243582 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_410718 V1243583 ENGB S Necessary for normal cell division and for the maintenance of normal septation (By similarity) COG0218 Cluster_859666 V1243584 RUBR C rubredoxin COG1773 Cluster_236116 V1243585 P cation diffusion facilitator family transporter COG0053 Cluster_653072 V1243586 L Pfam:Transposase_11 0YB49 Cluster_53053 V1243587 S Type II DNA modification methyltransferase 0ZM02 Cluster_888152 V1243588 SP_1222 V restriction endonuclease 0ZVJ1 Cluster_557777 V1243589 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_674303 V1243590 GPSA map00564 C NADPH-dependent glycerol-3-phosphate dehydrogenase COG0240 Cluster_414409 V1243591 PLSY map00561,map00564,map01100 S Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) COG0344 Cluster_119904 V1243592 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_310753 V1243593 S Membrane COG2966 Cluster_504778 V1243594 S Membrane COG3610 Cluster_251548 V1243595 TRAB S traB family COG1916 Cluster_218485 V1243596 C NADH flavin oxidoreductase NADH oxidase COG1902 Cluster_298200 V1243597 PROC map00330,map01100,map01110,map01230 E pyrroline-5-carboxylate reductase COG0345 Cluster_280389 V1243598 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_123468 V1243599 MURD map00471,map00550,map01100 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COG0771 Cluster_176149 V1243600 FTSW map04112 D cell division protein FtsW COG0772 Cluster_182998 V1243601 MURG map00550,map01100,map04112 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) COG0707 Cluster_434931 V1243603 EFP J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) COG0231 Cluster_625458 V1243604 S NA 0ZZHE Cluster_610583 V1243605 ASP S alkaline shock protein COG1302 Cluster_586061 V1243606 NUSB K Involved in the transcription termination process (By similarity) COG0781 Cluster_119905 V1243607 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_174538 V1243609 4HBD map00650 C NAD-dependent 4-hydroxybutyrate dehydrogenase COG1454 Cluster_509965 V1243610 SP_1680 G YhcH YjgK YiaL family protein COG2731 Cluster_271072 V1243611 SP_1682 G ABC transporter permease COG1175 Cluster_348969 V1243612 NANE map00520 G Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) COG3010 Cluster_449070 V1243613 I Acyltransferase COG0204 Cluster_245177 V1243614 AMID map02010 P ABC transporter, permease protein COG1173 Cluster_192611 V1243615 OPPD map02010 E ATP-binding protein COG0444 Cluster_246502 V1243616 OPPF map02010 E oligopeptide ABC transporter, ATP-binding protein COG4608 Cluster_109440 V1243617 FTSA map04112 D This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) COG0849 Cluster_194433 V1243618 DIVIB map04112 M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) COG1589 Cluster_191675 V1243619 MURG map00550,map01100,map04112 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) COG0707 Cluster_447054 V1243620 CAH map00910 P Carbonate dehydratase COG0288 Cluster_211624 V1243622 M Glycosyl transferase, family 2 COG1216 Cluster_285954 V1243623 SP_0742 S degv family COG1307 Cluster_176150 V1243624 S 5-bromo-4-chloroindolyl phosphate hydrolysis protein 111JX Cluster_176151 V1243625 TELA P Resistance protein COG3853 Cluster_465179 V1243626 MRAZ S Cell division protein mraZ COG2001 Cluster_239899 V1243627 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_23199 V1243629 FTSI map00550,map01100 M Stage V sporulation protein D COG0768 Cluster_151223 V1243630 S NA 11VKF Cluster_119906 V1243632 RUMA map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_699274 V1243633 DNAQ map03022,map03420 L helicase COG1199 Cluster_168544 V1243634 MDH map00010,map00071,map00260,map00350,map00561,map00620,map00625,map00626,map00630,map01100,map01110,map01120 C Dehydrogenase COG1454 Cluster_551976 V1243636 S NA 11UWB Cluster_389448 V1243637 PYRE map00240,map00983,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_348970 V1243638 COMF map00230,map00250,map01100,map01110 S Competence protein COG1040 Cluster_467269 V1243639 RECX S regulatory protein RecX 11Y5X Cluster_275092 V1243640 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_55505 V1243641 L DNA polymerase 0Y9P0 Cluster_73865 V1243643 S phage plasmid primase, p4 family COG3378 Cluster_283136 V1243644 YGCG S of methanol dehydrogenase type COG1512 Cluster_162062 V1243645 THII map00730,map01100,map04122 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) COG0301 Cluster_175349 V1243646 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_122841 V1243647 RIMO J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) COG0621 Cluster_447055 V1243648 PGSA map00564,map01100 I cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase COG0558 Cluster_499842 V1243649 CINA H competence damage-inducible protein COG1546 Cluster_175350 V1243651 M Sortase family COG3764 Cluster_480408 V1243658 REP L Replication Protein COG5527 Cluster_478002 V1243659 ISPF map00900,map01100,map01110 I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) COG0245 Cluster_300866 V1243660 map02010 P Cobalt transport protein COG0619 Cluster_228949 V1243661 LCDH map00360,map00362,map00650,map01100,map01120 C Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) COG1250 Cluster_196162 V1243662 S NA 0XS0Q Cluster_421558 V1243663 YGFC K Transcriptional regulator 120E9 Cluster_210493 V1243664 FETB map02010 P Periplasmic binding protein COG4607 Cluster_324566 V1243665 YCLP map02010 P abc transporter atp-binding protein COG4604 Cluster_230116 V1243666 SSTB map02010 P permease protein COG4605 Cluster_233718 V1243667 CEUB map02010 P permease protein COG4606 Cluster_252771 V1243669 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_39633 V1243670 LKTB3 V ABC transporter, ATP-binding protein COG2274 Cluster_238628 V1243671 LDH map00010,map00051,map00270,map00363,map00591,map00620,map00625,map00640,map00650,map01100,map01110,map01120 C Dehydrogenase COG0039 Cluster_52141 V1243672 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily COG1368 Cluster_155301 V1243673 E amidohydrolase COG1473 Cluster_27274 V1243674 O cysteine protease COG4870 Cluster_63752 V1243675 S CAMP factor (Cfa) 0Z1YX Cluster_403613 V1243677 SLYD O peptidylprolyl cis-trans isomerase COG1047 Cluster_183817 V1243678 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_252772 V1243679 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate COG0167 Cluster_315354 V1243680 PYRK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) COG0543 Cluster_144230 V1243681 FUSA2 T elongation factor G COG0480 Cluster_373612 V1243682 RPE map00030,map00040,map00710,map01100,map01110,map01120,map01230 G ribulose-phosphate 3-epimerase COG0036 Cluster_389449 V1243683 THIN map00730,map01100 H thiamine COG1564 Cluster_398317 V1243685 CYSE map00270,map00920,map01100,map01120,map01230 E serine acetyltransferase COG1045 Cluster_271073 V1243686 SP_0590 S acetyltransferase, (GNAT) family COG0456 Cluster_119138 V1243687 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_284511 V1243688 YPFJ S zinc metallopeptidase COG2321 Cluster_261692 V1243689 I Diacylglycerol kinase catalytic domain COG1597 Cluster_380602 V1243690 E asp glu hydantoin 11SZY Cluster_147302 V1243691 UUP S Abc transporter COG0488 Cluster_88122 V1243692 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_21408 V1243694 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_259075 V1243697 YAAT S psp1 domain protein COG1774 Cluster_36875 V1243698 S Secreted protein 0XRGW Cluster_487334 V1243699 FTNA map00860 P ferritin COG1528 Cluster_333578 V1243700 PHNC map02010 P phosphonate abc transporter COG3638 Cluster_264367 V1243701 PHND map02010 P phosphonate ABC transporter, periplasmic phosphonate-binding protein COG3221 Cluster_385920 V1243702 map00730,map01100 H IA, variant 3 COG0637 Cluster_269763 V1243703 GALU map00040,map00052,map00500,map00520,map01100,map01110 M UTP-glucose-1-phosphate uridylyltransferase COG1210 Cluster_678752 V1243705 UBIE map00340,map00350,map00624,map01120 Q methyltransferase COG0500 Cluster_653073 V1243707 PHOB map02020 T Response regulator receiver domain protein COG0745 Cluster_377091 V1243708 PHOU P Plays a role in the regulation of phosphate uptake COG0704 Cluster_326063 V1243709 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_265699 V1243710 PSTA map02010 P phosphate abc transporter COG0581 Cluster_280390 V1243711 PSTC map02010 P phosphate abc transporter COG0573 Cluster_392989 V1243712 XERD L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_106422 V1243713 BL00983 S Phage Portal Protein 11QNG Cluster_135888 V1243714 BL00759 L Phage terminase, large subunit COG1783 Cluster_475807 V1243715 PS333 L terminase (Small subunit) COG3728 Cluster_824817 V1243716 S Toxin-antitoxin system, antitoxin component, HicB family 12518 Cluster_452982 V1243717 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_353758 V1243718 YJHF map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_177804 V1243719 K anti-repressor COG3645 Cluster_210494 V1243721 S NA 0ZJRM Cluster_711675 V1243722 HUP L DNA-binding protein COG0776 Cluster_203986 V1243727 S Acyltransferase family 0YSHG Cluster_82130 V1243728 COMM O Mg chelatase subunit ChlI COG0606 Cluster_6989 V1243729 S Domain protein 11KBU Cluster_344156 V1243730 YUGP S zinc metallopeptidase COG2738 Cluster_242548 V1243731 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_471548 V1243732 DEF J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) COG0242 Cluster_57026 V1243733 S s-layer domain protein 12BYN Cluster_416179 V1243734 THID map00730,map01100 H phosphomethylpyrimidine kinase COG0351 Cluster_352091 V1243735 MTNN map00270,map01100 F Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) COG0775 Cluster_487335 V1243736 LUXS map00270,map05111 T Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) COG1854 Cluster_350591 V1243737 S NA 0ZAT5 Cluster_480409 V1243739 N Cell surface protein 0XQ7Y Cluster_172899 V1243740 BCOA_0505 L transposase COG0675 Cluster_35172 V1243741 L Topoisomerase COG0550 Cluster_11434 V1243744 S NA 12D1P Cluster_678753 V1243745 HSDM V type I restriction-modification system COG0286 Cluster_310754 V1243746 HALSA_0542 L Transposase COG2801 Cluster_285955 V1243747 SAGE S CAAX amino protease family protein 0XUJM Cluster_279086 V1243749 S YycH protein 0ZZRJ Cluster_307887 V1243750 VICX map03013 S domain protein COG1235 Cluster_310755 V1243751 SURE map00230,map00240,map00760,map01100,map01110 F Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) COG0496 Cluster_164501 V1243752 PATB map00270,map00450,map00920,map01100,map01110,map01230 E Aminotransferase class I and II COG1168 Cluster_460976 V1243753 YXIE T Universal stress protein COG0589 Cluster_171166 V1243754 BCD map00071,map00280,map00281,map00650,map01100,map01110 I acyl-CoA dehydrogenase COG1960 Cluster_302241 V1243755 ETFB map00910 C Electron transfer flavoprotein COG2086 Cluster_212714 V1243756 ETFA map00910 C Electron transfer flavoprotein COG2025 Cluster_748189 V1243757 map01053 Q amino acid adenylation COG1020 Cluster_336610 V1243758 SSCG_03340 S Membrane COG2860 Cluster_592738 V1243760 YUGI J RNA binding s1 domain protein COG1098 Cluster_106423 V1243761 PPIB O PPIases accelerate the folding of proteins COG0652 Cluster_389450 V1243762 VRAR map02020 T response regulator COG2197 Cluster_217351 V1243763 VRAS map02020 T Histidine kinase COG4585 Cluster_482726 V1243764 RFE M Glycosyl transferase, family 4 COG0472 Cluster_135889 V1243765 N, U spore coat assembly protein SafA COG1388 Cluster_41699 V1243766 HPPA map00190 C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for COG3808 Cluster_543102 V1243767 C Flavodoxin COG0716 Cluster_4747 V1243768 S NA 0YZ82 Cluster_403614 V1243770 YCF O cytochrome C COG0755 Cluster_21492 V1243771 S s-layer domain-containing protein 11ZJU Cluster_35432 V1243773 GLNN map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG3968 Cluster_348971 V1243774 E Pfam:DapD_N COG2171 Cluster_174539 V1243775 HIPO map00300,map00360,map01100,map01110,map01230 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate (By similarity) COG1473 Cluster_362026 V1243776 GLPG S Rhomboid family COG0705 Cluster_149595 V1243778 YWFO S Phosphohydrolase COG1078 Cluster_291314 V1243779 PYRF map00240,map00983,map01100 F orotidine 5''-phosphate decarboxylase COG0284 Cluster_180342 V1243780 PRFA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) COG0216 Cluster_502375 V1243786 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_142781 V1243787 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_170343 V1243789 METE map00270,map00450,map01100,map01110,map01230 E Methionine synthase COG0620 Cluster_347365 V1243790 SUPH S Hydrolase COG0561 Cluster_452983 V1243791 S Virulence-associated protein e COG5545 Cluster_260378 V1243792 L DNA primase 11GUV Cluster_118409 V1243793 SP_1634 S Protein of unknown function (DUF2974) 0XSVF Cluster_512537 V1243794 LOLD map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_192613 V1243795 AROB map00400,map01100,map01110,map01230 E 3-dehydroquinate synthase COG0337 Cluster_164502 V1243796 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_284512 V1243797 YXAA S Membrane COG0730 Cluster_582871 V1243798 YWJH S integral membrane protein COG4272 Cluster_110749 V1243799 GLMU map00520,map01100,map01110 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) COG1207 Cluster_234910 V1243800 PRS map00030,map00230,map01100,map01110,map01120,map01230 E, F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_339288 V1024205 NRDA map00230,map00240,map00480,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_340742 V1024207 S Virulence-associated protein e COG5545 Cluster_339289 V1024208 MURD map00471,map00550,map01100 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COG0771 Cluster_522530 V1024209 S Ankyrin repeat protein COG0666 Cluster_340743 V1024214 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins COG0706 Cluster_339290 V1024215 S Multi-copper polyphenol oxidoreductase laccase COG1496 Cluster_494059 V1024218 YYAT map00350,map00362,map00627,map00642,map00903,map01120 Q acetyltransferase 121PI Cluster_413995 V1024219 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_340744 V1024220 K Tetr family transcriptional regulator 17MTG@proNOG Cluster_369978 V1024224 map03060,map03070 U sec-independent protein 0ZXQT Cluster_340746 V1024226 FEPC map02010 P ABC transporter COG1120 Cluster_350221 V1024230 GBRO_2584 L integrase family COG0582 Cluster_342223 V1024231 GLNS map00970,map01100 J glutaminyL-tRNA synthetase COG0008 Cluster_342224 V1024232 M Inherit from COG: YD repeat protein COG3209 Cluster_394355 V1024234 YBBP S TIGR00159 family COG1624 Cluster_677639 V1024236 RPSJ map03010 J Involved in the binding of tRNA to the ribosomes (By similarity) COG0051 Cluster_342226 V1024240 KDPA map02020 P One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) COG2060 Cluster_342227 V1024242 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_342228 V1024243 MT2607 map00330,map00480,map01100,map01110 E decarboxylase COG1982 Cluster_613276 V1024245 RSFS S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) COG0799 Cluster_591861 V1024247 S peptidase M15 0Y4QW Cluster_620758 V1024248 RPSP map03010 J 30s ribosomal protein S16 COG0228 Cluster_342229 V1024252 XYLT map04113 G transporter 0XNQK Cluster_413996 V1024261 PDXY map00750,map01100 H functions in a salvage pathway. Uses pyridoxamine (By similarity) COG2240 Cluster_581986 V1024262 S Appr-1-p processing domain protein COG2110 Cluster_364942 V1024263 map00010,map00500,map00520,map02060 G phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 COG2190 Cluster_342230 V1024264 ICD map00020,map00480,map00720,map01100,map01110,map01120,map01210,map01230,map04146 C Isocitrate dehydrogenase COG2838 Cluster_819720 V1024265 NUOK map00190,map00910,map01100 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) COG0713 Cluster_452520 V1024266 NDHG map00190,map00910,map01100 C NADH-ubiquinone plastoquinone oxidoreductase chain 6 1208F Cluster_673143 V1024269 YITW O fes assembly suf system protein COG2151 Cluster_343824 V1024271 C FMN-binding domain protein COG3976 Cluster_720787 V1024274 GROS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) COG0234 Cluster_635923 V1024275 CHPA T transcriptional modulator of maze toxin, mazf COG2337 Cluster_743947 V1024276 CHPR K transcriptional regulator antitoxin, MazE COG2336 Cluster_345421 V1024277 S tape measure domain protein 11PSY Cluster_757747 V1024278 S NA 0ZHU9 Cluster_548292 V1024279 SP_1924 S NA 0Y6AG Cluster_343826 V1024281 YKOD map02010 P ABC transporter COG1122 Cluster_343827 V1024282 ACRB3 P acriflavin resistance protein COG0841 Cluster_343828 V1024284 YBGQ map05133 M outer membrane usher protein COG3188 Cluster_572451 V1024286 I Endonuclease Exonuclease phosphatase COG3568 Cluster_514532 V1024290 K Transcriptional regulator, BadM Rrf2 family COG1959 Cluster_394356 V1024292 S NA 0Y3S5 Cluster_462593 V1024293 J rrna methyltransferase COG0566 Cluster_740695 V1024294 CYCMA_1561 L Transposase COG3436 Cluster_724165 V1024295 RPST map03010 J Binds directly to 16S ribosomal RNA (By similarity) COG0268 Cluster_345422 V1024296 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_345423 V1024301 ACIN_0074 L Transposase COG3464 Cluster_458413 V1024305 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_628203 V1024311 S NA 0Z1A1 Cluster_511897 V1024315 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_928115 V1024316 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_647924 V1024317 PHNP map00440 S Beta-lactamase domain protein COG1235 Cluster_780115 V1024320 INFA J however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) COG0361 Cluster_691189 V1024321 S Protein of unknown function (DUF1021) 12B1F Cluster_598859 V1024322 CRCB2 D Protein CrcB homolog COG0239 Cluster_387330 V1024324 ASPA map00250,map00910,map01100 E Aspartate ammonia-lyase COG1027 Cluster_808237 V1024325 BMUL_5595 S PRTRC system ThiF family protein 17DFD@proNOG Cluster_489073 V1024326 S Domain of unknown function (DUF2016) 17I37@proNOG Cluster_542268 V1024328 YIHG map00350,map00362,map00627,map00642,map00903,map01120 I Acyl-transferase COG0204 Cluster_585223 V1024330 S NA 0Z0H8 Cluster_724166 V1024332 ADK map00230,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_348649 V1024333 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_720789 V1024334 map00920,map01100,map01120 S PepSY-associated TM helix COG3182 Cluster_522531 V1024335 SPEG map00330,map00350,map00362,map00627,map00642,map00903,map01100,map01120 J spermidine N(1)-acetyltransferase COG1670 Cluster_363234 V1024337 YFMD map02010 P transport system permease protein COG0609 Cluster_519829 V1024339 SCLAV_1469 K Tetr family transcriptional regulator 11SST Cluster_562971 V1024341 ARSB P arsenical pump membrane protein COG1055 Cluster_668876 V1024342 ARSR K Transcriptional regulator, arsR family COG0640 Cluster_585224 V1024343 NHAR K transcriptional regulator, lysR family COG0583 Cluster_350222 V1024345 E peptidase 0XRNU Cluster_475254 V1024346 P TonB-dependent receptor Plug 0XQ9V Cluster_560070 V1024349 T response regulator COG2197 Cluster_350223 V1024350 M Glycosyl hydrolase, family 25 COG3757 Cluster_714252 V1024352 RPSO map03010 J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) COG0184 Cluster_776550 V1024353 S phage protein 1262M Cluster_724167 V1024355 L integrase family 0XRS7 Cluster_432581 V1024357 L site-specific recombinase, phage integrase family 0ZF8H Cluster_812239 V1024360 HSLR J Heat shock protein COG1188 Cluster_350225 V1024364 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_557021 V1024365 S NA 11SPJ Cluster_879023 V1024367 ACRB3 P acriflavin resistance protein COG0841 Cluster_460469 V1024368 BMUL_1520 M efflux transporter, rnd family, mfp subunit COG0845 Cluster_434465 V1024369 PGL map00030,map01100,map01110,map01120 G 6-phosphogluconolactonase (EC 3.1.1.31) COG0363 Cluster_511898 V1024370 DTD J Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) COG1490 Cluster_351768 V1024371 S peptidase family M49 0XRK4 Cluster_887169 V1024374 ACRR K Transcriptional regulator, TetR family COG1309 Cluster_717511 V1024376 HUPA L DNA-binding protein COG0776 Cluster_609630 V1024378 S NA 11KVS Cluster_562973 V1024381 S NA 1229H Cluster_353449 V1024382 M efflux transporter, rnd family, mfp subunit COG0845 Cluster_399653 V1024385 CADA P p-type atpase COG2217 Cluster_691191 V1024387 GTO2 O Glutathione S-transferase COG0435 Cluster_353451 V1024389 CSP1 M LGFP repeat COG5479 Cluster_351769 V1024391 WBPO map00051,map00520,map02020 M Dehydrogenase COG0677 Cluster_554133 V1024392 GLSA map00250,map00330,map00471,map00910,map01100,map01120,map04724,map04727,map04964 E Glutaminase COG2066 Cluster_381959 V1024393 UVRA map03420 L Inherit from bactNOG: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_704628 V1024394 S NA 0ZHU9 Cluster_427139 V1243801 PTH J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) COG0193 Cluster_157832 V1243802 map03420 K, L transcription-repair coupling factor COG1197 Cluster_206151 V1243803 S Acyl-transferase 128XF Cluster_176964 V1243804 S Acyltransferase 0XZUT Cluster_302242 V1243805 S Transcriptional regulator 11MVX Cluster_15707 V1243806 S NA 11QTV Cluster_67895 V1243809 S copper amine 0XP8R Cluster_460977 V1243810 APT map00230,map01100 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) COG0503 Cluster_291315 V1243811 TTCA D Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) COG0037 Cluster_51330 V1243814 S domain protein 0YF83 Cluster_279087 V1243815 RPSB map03010 J 30S ribosomal protein S2 COG0052 Cluster_365338 V1243816 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_341043 V1243817 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_254016 V1243818 C radical SAM domain protein COG1032 Cluster_249076 V1243819 map02010 V ABC transporter COG1131 Cluster_233719 V1243821 HPKA T Histidine kinase 11IN2 Cluster_139006 V1243822 SUFD O feS assembly protein SufD COG0719 Cluster_23200 V1243824 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_175351 V1243825 TGT J Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COG0343 Cluster_350592 V1243826 T Two component transcriptional regulator, winged helix family COG0745 Cluster_124107 V1243827 MGTE P magnesium transporter COG2239 Cluster_434932 V1243828 K HTH_XRE 0XUC3 Cluster_439029 V1243829 S Inherit from COG: Membrane COG3601 Cluster_378875 V1243830 map00564,map01100 I PAP2 Family COG0671 Cluster_237310 V1243831 YTQA S Radical SAM Protein COG1242 Cluster_441014 V1243832 YTQB map00340,map00350,map00624,map01120 Q rRNA Methylase COG0500 Cluster_4535 V1243834 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_221991 V1243835 S oxidoreductase COG0673 Cluster_151224 V1243836 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_384143 V1243837 S FMN_bind 12BR0 Cluster_280391 V1243838 map02010 V ABC transporter COG1136 Cluster_182097 V1243839 WECB map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_205066 V1243840 TAGO M Glycosyl transferase, family 4 COG0472 Cluster_392990 V1243841 UPP map00240,map01100 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) COG0035 Cluster_531724 V1243842 RPIB map00030,map00052,map00710,map01100,map01110,map01120,map01230 G isomerase COG0698 Cluster_391179 V1243843 MUTT L hydrolase COG0494 Cluster_200904 V1243844 S Phospholipase, patatin family 0YEF4 Cluster_543103 V1243845 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_543104 V1243846 COMEB map00240,map01100 F deaminase COG2131 Cluster_408868 V1243847 RNHA map03030 S ribonuclease COG3341 Cluster_83401 V1243848 NAGE map00010,map00500,map00520,map02060 G PTS System COG1264 Cluster_205067 V1243849 E m42 family COG1363 Cluster_261693 V1243851 FDA map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01230 G fructose-bisphosphate aldolase COG3588 Cluster_820836 V1243852 S NA 0ZHU9 Cluster_246503 V1243854 JAG S Single-stranded nucleic acid binding R3H domain-containing protein COG1847 Cluster_305195 V1243855 POTC map02010 P putrescine abc transporter COG1177 Cluster_296806 V1243856 POTB map02010 P ABC transporter, permease COG1176 Cluster_447056 V1243857 PUUR K Transcriptional regulator COG1396 Cluster_777464 V1243858 GROS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) COG0234 Cluster_73151 V1243859 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_132659 V1243860 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_824818 V1243862 S NA 0YTRC Cluster_160397 V1243863 map00230,map01100,map01110 F AICARFT/IMPCHase bienzyme COG0138 Cluster_50165 V1243865 CWLV M n-acetylmuramoyl-l-alanine amidase COG0860 Cluster_275093 V1243867 SPPA O, U Signal peptide peptidase, SppA COG0616 Cluster_181166 V1243868 THIL map00730,map01100 H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) COG0611 Cluster_167694 V1243869 S Divergent AAA domain protein 0XW6W Cluster_61560 V1243871 NIST map02010 V ABC transporter 0XPIZ Cluster_179512 V1243872 HFLX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COG2262 Cluster_358787 V1243873 NADD map00230,map00760,map01100,map05340 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) COG1057 Cluster_102806 V1243874 PEPD E Dipeptidase COG4690 Cluster_817007 V1243875 SECE map03060,map03070 U Preprotein translocase SecE subunit 0XUXP Cluster_410719 V1243876 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_537406 V1243877 RPLK map03010 J This protein binds directly to 23S ribosomal RNA (By similarity) COG0080 Cluster_352092 V1243878 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_451037 V1243879 RPLJ map03010 J 50s ribosomal protein L10 COG0244 Cluster_582872 V1243880 RPLL map03010 J Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) COG0222 Cluster_485047 V1243881 CYSE S -acetyltransferase 11PF0 Cluster_275094 V1243887 L PriCT_1 11P4Z Cluster_98974 V1243888 S DNA primase COG3378 Cluster_35048 V1243890 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_254017 V1243891 I Diacylglycerol kinase COG1597 Cluster_212715 V1243892 CCPA K Transcriptional regulator, LacI family COG1609 Cluster_389451 V1243893 K Transcriptional regulator, GntR family COG1802 Cluster_210495 V1243894 L site-specific recombinase, phage integrase family 11IW4 Cluster_419761 V1243897 S Domain of unknown function (DUF955) 0ZI1U Cluster_614256 V1243898 K Transcriptional regulator (XRE family COG1396 Cluster_294054 V1243899 RLML L Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) COG0116 Cluster_888153 V1243901 HOM map00260,map00270,map00300,map01100,map01110,map01120,map01230 E homoserine dehydrogenase COG0460 Cluster_223164 V1243902 ASD map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) COG0136 Cluster_123469 V1243903 YCLM map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Aspartokinase COG0527 Cluster_234911 V1243905 TRAN S Conjugative transposon TraN protein 0XNQ2 Cluster_230117 V1243907 O Band 7 protein COG0330 Cluster_408869 V1243908 DESR map02020 T response regulator COG2197 Cluster_183818 V1243909 DESK map02020 T Histidine kinase COG4585 Cluster_335080 V1243910 YVFS map02010 V ABC transporter COG0842 Cluster_333580 V1243911 PDXT map00750 H Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) COG0311 Cluster_329111 V1243912 PDXS map00750 H Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) COG0214 Cluster_316877 V1243913 OCAR_6752 H DNA integration recombination invertion protein COG1636 Cluster_385921 V1243914 DCK map00230,map00240,map01100 F deoxynucleoside kinase COG1428 Cluster_180343 V1243915 S NA 11FT3 Cluster_130354 V1243917 RARA L recombination factor protein RarA COG2256 Cluster_188195 V1243918 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_425219 V1243919 PTH J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) COG0193 Cluster_114223 V1243920 GLMU map00520,map01100,map01110 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) COG1207 Cluster_401836 V1243921 GST map00480,map00980,map00982,map05204 O Glutathione S-transferase COG0625 Cluster_410720 V1243922 THIF map00730,map01100,map04122 H Thiamine biosynthesis protein ThiF COG0476 Cluster_167695 V1243923 THIH map00730,map01100 H biosynthesis protein thiH COG1060 Cluster_209416 V1243924 CIAB S Ciab protein 0XNU4 Cluster_81756 V1243925 HSDM V HsdM N-terminal domain COG0286 Cluster_489684 V1243926 S domain protein COG1418 Cluster_436991 V1243927 FOLE map00790,map01100 H GTP cyclohydrolase i COG0302 Cluster_177805 V1243929 S gtp-binding protein COG3596 Cluster_373615 V1243930 MURD map00471,map00550,map01100 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COG0771 Cluster_145730 V1243931 AROA map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate synthase COG0128 Cluster_187334 V1243932 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_92820 V1243933 RODA D rod shape-determining protein RodA COG0772 Cluster_53516 V1243934 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_441015 V1243935 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_112773 V1243936 TILS D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) COG0037 Cluster_130355 V1243937 S NA 0ZDUW Cluster_254018 V1243939 HSDM V type I restriction-modification system COG0286 Cluster_70894 V1243941 CSHA map03018 L DEAD DEAH box helicase COG0513 Cluster_699275 V1243942 P Rhodanese domain protein COG0607 Cluster_586062 V1243943 J endoribonuclease L-psp COG0251 Cluster_606926 V1243944 RSFS S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) COG0799 Cluster_283137 V1243945 LYTR K TRANSCRIPTIONal COG1316 Cluster_443017 V1243946 PHOH T Phoh family COG1702 Cluster_18763 V1243948 PPDK map00620,map00710,map01100,map01120 G pyruvate phosphate dikinase COG0574 Cluster_517908 V1243949 YQFL S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) COG1806 Cluster_339581 V1243952 GLNQ E abc transporter atp-binding protein COG1126 Cluster_363596 V1243953 ARTQ E ABC transporter COG0765 Cluster_276421 V1243954 map02010 E, T ABC transporter substrate-binding protein COG0834 Cluster_158701 V1243955 S transporter gate domain protein 0XRV8 Cluster_625459 V1243957 RPLT map03010 J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) COG0292 Cluster_554872 V1243960 S NA 0YX61 Cluster_487336 V1243961 L terminase (Small subunit) COG3728 Cluster_135075 V1243962 BL00759 L Phage terminase, large subunit COG1783 Cluster_116303 V1243963 BL00983 S Phage Portal Protein 11QNG Cluster_28769 V1243964 OATA I Acyl-transferase COG1835 Cluster_319943 V1243967 XTH map03410 L Exodeoxyribonuclease III COG0708 Cluster_141279 V1243971 L Inherit from COG: DNA Methylase COG0827 Cluster_507360 V1243972 CTSR K transcriptional regulator, ctsr COG4463 Cluster_431019 V1243973 MCSA S Uvrb UvrC protein COG3880 Cluster_203987 V1243974 MCSB map00330 E ATP guanido phosphotransferase COG3869 Cluster_47293 V1243975 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins COG0706 Cluster_175352 V1243976 GLF M udp-galactopyranose mutase COG0562 Cluster_128907 V1243977 S Na H antiporter COG2056 Cluster_520474 V1243978 ZURR K Ferric uptake regulator, Fur family COG0735 Cluster_245178 V1243979 S ABC transporter substrate-binding protein 0ZK3U Cluster_150464 V1243980 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_463099 V1243981 YMDB S appr-1-p processing domain protein COG2110 Cluster_341044 V1243982 S NA 0Z20Q Cluster_405428 V1243983 S cbs domain containing protein 0ZNI1 Cluster_653074 V1243984 V Mate efflux family protein COG0534 Cluster_433015 V1243985 map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aminotransferase COG0436 Cluster_352093 V1243986 FOLE map00790,map01100 H GTP cyclohydrolase i COG0302 Cluster_618011 V1243987 FOLP map00790,map01100 H dihydropteroate synthase COG0294 Cluster_234912 V1243989 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_116304 V1243990 NTPJ P Potassium uptake protein COG0168 Cluster_373616 V1243991 KTRA P domain protein COG0569 Cluster_333581 V1243992 UBIE map00130,map01100,map01110 H Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) COG2226 Cluster_327618 V1243993 AROE map00400,map01100,map01110,map01230 E Shikimate dehydrogenase COG0169 Cluster_164503 V1243994 PURM map00230,map01100,map01110 F Phosphoribosylformylglycinamidine cyclo-ligase COG0150 Cluster_467270 V1243995 NOX map00190 P pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_412529 V1243998 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_207248 V1243999 MREB D Rod shape-determining protein mreb COG1077 Cluster_47872 V1244000 map02020 V ABC transporter, permease COG0577 Cluster_157833 V1244001 S NA 0XT4D Cluster_695990 V1244002 S excisionase 11NUM Cluster_396592 V1244003 S NA 11KVS Cluster_487337 V1244004 ARGR K Regulates arginine biosynthesis genes (By similarity) COG1438 Cluster_770044 V1244005 PSPC S phage shock protein C, PspC COG1983 Cluster_310756 V1244006 PROC map00330,map01100,map01110,map01230 E pyrroline-5-carboxylate reductase COG0345 Cluster_246504 V1244007 C Alcohol dehydrogenase zinc-binding domain protein COG1063 Cluster_102267 V1244008 MGTE P magnesium transporter COG2239 Cluster_178644 V1244009 UGTP map00561,map01100 M Monogalactosyldiacylglycerol synthase COG0707 Cluster_156113 V1244010 FPRA C domain protein COG0426 Cluster_824819 V1244011 S Hydrid cluster protein-associated redox disulfide domain protein 123UM Cluster_378876 V1244012 FAT map00061,map01100 I Acyl-ACP thioesterase COG3884 Cluster_264369 V1244013 FTCD map00340,map00670,map01100 E Glutamate formiminotransferase COG3643 Cluster_216155 V1244014 UPPP map00550 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) COG1968 Cluster_57278 V1244015 P Voltage gated chloride channel COG0038 Cluster_427140 V1244016 J sua5 ycio yrdc ywlc family protein COG0009 Cluster_256457 V1244017 DDH map00300,map01100,map01110,map01230 E Diaminopimelate dehydrogenase 0XPX2 Cluster_164504 V1244018 S metallophosphoesterase COG1408 Cluster_357118 V1244019 TRMK S SAM-dependent methyltransferase COG2384 Cluster_365339 V1244020 DNAD L DNA replication protein DnaD COG3935 Cluster_237311 V1244021 META map00270,map00920,map01100,map01110,map01230 E Homoserine O-transsuccinylase COG1897 Cluster_465180 V1244022 APT map00230,map01100 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) COG0503 Cluster_306582 V1244023 NATB C, P ABC transporter, permease COG1668 Cluster_145731 V1244024 S ybbr family COG4856 Cluster_273737 V1244025 YBBP S TIGR00159 family COG1624 Cluster_60147 V1244026 PEPF E Oligoendopeptidase f COG1164 Cluster_103436 V1244027 ASPA map00250,map00910,map01100 E Aspartate ammonia-lyase COG1027 Cluster_163707 V1244028 S Filamentation induced by cAMP protein fic COG3177 Cluster_152058 V1244029 M glycosyl transferase group 1 0ZVDW Cluster_475809 V1244030 YTSP T gaf domain protein COG1956 Cluster_751603 V1244031 S Transglycosylase-associated protein 0XWD0 Cluster_68568 V1244032 YLOV S dak2 domain fusion protein ylov COG1461 Cluster_820837 V1244033 RPMB map03010 J 50S ribosomal protein l28 COG0227 Cluster_625460 V1244035 S Coenzyme PQQ synthesis protein D (PqqD) 11PNC Cluster_322984 V1244036 GUFA P Mediates zinc uptake. May also transport other divalent cations (By similarity) COG0428 Cluster_322985 V1244037 S NA 128YG Cluster_60148 V1244038 M NA 11FBZ Cluster_153667 V1244039 V Transporter Permease Protein COG0577 Cluster_417984 V1244040 TRPG map00230,map00400,map00790,map00983,map01100,map01110,map01230 E anthranilate synthase COG0512 Cluster_122842 V1244041 PABB map00790 E synthase component I COG0147 Cluster_648994 V1244042 YAAQ S protein from nitrogen regulatory protein P-II COG3870 Cluster_392991 V1244043 TMK map00240,map01100 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) COG0125 Cluster_104010 V1244044 YAAO map00310,map00330,map00960,map01100,map01110 E decarboxylase COG1982 Cluster_178645 V1244047 S YibE F family protein COG5438 Cluster_23494 V1244048 RECG map03440 L ATP-dependent DNA helicase RecG COG1200 Cluster_460978 V1244049 S NA 0Z9F2 Cluster_302244 V1244050 S NA 0YXZ1 Cluster_189034 V1244051 RNHA map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0328 Cluster_167696 V1244052 NQRB C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG1805 Cluster_345770 V1244053 NQRC C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG2869 Cluster_391180 V1244054 NQRD C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG1347 Cluster_482727 V1244055 ISIB map00910,map01120 C Low-potential electron donor to a number of redox enzymes (By similarity) COG0716 Cluster_267010 V1244056 S peptidase, S41 11FNN Cluster_90432 V1244058 S peptidase, S41 11FNN Cluster_520475 V1244059 DTD J Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) COG1490 Cluster_31743 V1244060 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_17974 V1244062 S s-layer domain-containing protein 11ZJU Cluster_303692 V1244063 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_136700 V1244064 CINA H competence damage-inducible protein COG1546 Cluster_777465 V1244065 Y1260 S Membrane COG2510 Cluster_708531 V1244066 O Matrixin COG5549 Cluster_305196 V1244067 ESTA S esterase COG0627 Cluster_69269 V1244068 RNJB map03018 O Metallo-Beta-Lactamase COG0595 Cluster_114224 V1244069 map02010 P ABC transporter COG1122 Cluster_357119 V1244070 map02010 P Cobalt transport protein COG0619 Cluster_179513 V1244071 P Phosphate-Selective Porin O and P 0ZV9B Cluster_101153 V1244072 RUMA map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_269764 V1244073 map02010 P extracellular solute-binding protein COG1840 Cluster_755075 V1244074 S NA 0ZYXP Cluster_467271 V1244075 map00350,map00362,map00627,map00642,map00903,map01120 S -acetyltransferase 11PF0 Cluster_342560 V1244076 SFSA L Sugar fermentation stimulation protein homolog COG1489 Cluster_456942 V1244077 YCGH Q isochorismatase COG1335 Cluster_417985 V1244078 FUCA map00051 G Class II aldolase adducin family protein COG0235 Cluster_531725 V1244080 S Relaxase mobilization nuclease 0Y9PG Cluster_219643 V1244082 ATU2672 S ABC transporter COG2984 Cluster_269765 V1244083 BMUL_0473 S ABC transporter, permease COG4120 Cluster_291316 V1244084 SP_1071 S abc transporter atp-binding protein COG1101 Cluster_230118 V1244085 ANSA map00250,map00460,map00910,map01100,map01110 E l-asparaginase (EC 3.5.1.1) COG0252 Cluster_512538 V1244086 S OsmC-like protein 124NV Cluster_288724 V1244087 P phosphonate ABC transporter substrate-binding protein COG3221 Cluster_319944 V1244090 L Bacterial dnaA protein COG1484 Cluster_46925 V1244091 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_387748 V1244092 YMDB S appr-1-p processing domain protein COG2110 Cluster_13458 V1244094 map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_185575 V1244095 BL01967 P trap transporter solute receptor taxi family COG2358 Cluster_451038 V1244096 S Domain of unknown function (DUF1850) 12957 Cluster_38496 V1244097 S trap transporter, 4tm 12tm fusion protein COG4666 Cluster_151225 V1244098 GLXK map00260,map00561,map00630,map01100,map01110 G Glycerate kinase COG1929 Cluster_58800 V1244099 SPPA O, U Signal peptide peptidase, SppA COG0616 Cluster_246505 V1244100 O peptidase, M48 COG0501 Cluster_256458 V1244101 CYNR K Transcriptional regulator 0ZWMP Cluster_260379 V1244102 S Lipoprotein 120BJ Cluster_212716 V1244103 GAP map00010,map01100,map01110,map01120,map01230,map04066,map05010 G Glyceraldehyde-3-phosphate dehydrogenase COG0057 Cluster_312272 V1244104 WANG_1499 S Transposase 11N3I Cluster_128908 V1244105 ATPC map00190,map00680,map01100 C ATP synthase, subunit 0XPA7 Cluster_125419 V1244106 T Histidine kinase 0XNMH Cluster_74821 V1244108 S (LipO)protein 0Z3DA Cluster_225522 V1244110 BSH map00120,map00121,map01100 M Choloylglycine hydrolase COG3049 Cluster_95211 V1244111 TRAA map03440 L mobA MobL family protein COG0507 Cluster_201894 V1244112 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_497176 V1244113 S NA 0ZAGT Cluster_114225 V1244114 PGDA G deacetylase COG0726 Cluster_61814 V1244115 map02010 V ABC transporter COG1132 Cluster_52595 V1244116 V ABC transporter COG1132 Cluster_88579 V1244118 PRE S plasmid recombination enzyme 0XTDI Cluster_507361 V1244120 S Toxin-antitoxin system, toxin component, RelE family COG4680 Cluster_352094 V1244123 COBB map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_368660 V1244124 S copper amine 121X1 Cluster_139789 V1244125 S Inherit from COG: virion core protein (Lumpy skin disease COG4260 Cluster_84721 V1244126 YDJG S Zinc finger domain 0XNNM Cluster_231293 V1244129 S repeat protein 11IAG Cluster_433016 V1244130 map00540,map01100 S Phage-related protein 11PAV Cluster_482728 V1244134 SP_0161 K, T lytTr DNA-binding domain protein COG3279 Cluster_586063 V1244135 S Inherit from NOG: MaoC family 11UTE Cluster_458925 V1244136 S NA 0XYT7 Cluster_277727 V1244137 DAM map03430 L Dna adenine methylase COG0338 Cluster_126809 V1244138 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_344157 V1244139 NFSA map00051,map00190,map00363,map00591,map00625,map00633,map00650,map01100,map01120 C nitroreductase COG0778 Cluster_283138 V1244140 NUCS L Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) COG1637 Cluster_192614 V1244141 PRFA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) COG0216 Cluster_305197 V1244142 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_257745 V1244143 YQHQ J Metal-dependent enzyme COG3872 Cluster_175353 V1244145 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_567000 V1244146 ISCR K Transcriptional regulator, BadM Rrf2 family COG1959 Cluster_509966 V1244147 ISCU C SUF system FeS assembly protein, NifU family COG0822 Cluster_144231 V1244148 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_135076 V1244149 S Protein of unknown function (DUF3078) 11J6J Cluster_151226 V1244151 S ATPase (AAA COG1373 Cluster_139790 V1244153 SP_0145 G Major Facilitator COG0477 Cluster_702340 V1244154 RPMA map03010 J 50S ribosomal protein l27 COG0211 Cluster_520476 V1244158 ADCR K Transcriptional 0XUB6 Cluster_348972 V1244159 map02010 P (ABC) transporter COG1121 Cluster_32568 V1244160 S NA 0YBPX Cluster_683295 V1244162 L NA 0YKV1 Cluster_512539 V1244163 S NA 0ZRDA Cluster_114895 V1244164 DAPE1 map00300,map00310,map00330,map00780,map01100,map01110,map01120,map01210,map01230 E peptidase COG0624 Cluster_836259 V1244165 NRDH O (Glutaredoxin-like protein) NrdH COG0695 Cluster_34201 V1244166 NRDE map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_341045 V1244167 PROV map02010 E ABC transporter COG1125 Cluster_419762 V1244168 C oxidoreductase COG0604 Cluster_657204 V1244169 C oxidoreductase COG0604 Cluster_352095 V1244170 YODJ M carboxy-peptidase COG1876 Cluster_820839 V1244171 S NA 1260K Cluster_212717 V1244172 S Nucleotidyl transferase of unknown function (DUF1814) 0XP6B Cluster_443018 V1244174 PGSA map00564,map01100 I cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase COG0558 Cluster_185576 V1244175 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_206152 V1244176 OCAR_5486 H Molybdopterin binding domain protein COG0303 Cluster_45175 V1244177 map02020 V ABC transporter, permease COG0577 Cluster_385922 V1244178 ADK map00230,map00240,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_579622 V1244179 RPSK map03010 J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) COG0100 Cluster_239900 V1244180 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_482729 V1244181 SP_1019 map00330,map01100 E -acetyltransferase 11VQY Cluster_281730 V1244182 S domain protein 0XNZW Cluster_296807 V1244183 S NA 0Z7KY Cluster_336611 V1244184 S NA 0Z7KY Cluster_480410 V1244185 NSPC map00330 E Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) COG0019 Cluster_324567 V1244186 K Transcriptional regulator COG2932 Cluster_809251 V1244188 S DNA-binding helix-turn-helix protein 0ZDJ9 Cluster_371997 V1244193 YXJI S Pfam:DUF567 COG4894 Cluster_275095 V1244195 YHBJ S Displays ATPase and GTPase activities (By similarity) COG1660 Cluster_254019 V1244196 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_589369 V1244197 ARSR K Transcriptional regulator, arsR family COG0640 Cluster_198910 V1244198 ARSB P arsenicaL-resistance protein COG0798 Cluster_234913 V1244199 S radical SAM domain protein COG4277 Cluster_336612 V1244200 S DNA metabolism protein 11MJI Cluster_280392 V1244201 NAGA map00520,map01110 G GlcNAc 6-P deacetylase COG1820 Cluster_73521 V1244202 PTSI map00051,map01100,map02060 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) COG1080 Cluster_734778 V1244203 map02060 G phosphocarrier protein (HPr) COG1925 Cluster_319945 V1244204 FOCA P Formate nitrite transporter COG2116 Cluster_142003 V1244205 LYSA map00260,map00270,map00300,map00330,map00480,map01100,map01110,map01120,map01230 E diaminopimelate decarboxylase COG0019 Cluster_360451 V1244206 YBHL S Membrane COG0670 Cluster_480411 V1244207 S HD domain protein COG1418 Cluster_586064 V1244208 PITA P phosphate transporter COG0306 Cluster_78117 V1244209 NHAP P Potassium proton antiporter COG3263 Cluster_148833 V1244211 ASPC map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aminotransferase class I and II COG0436 Cluster_9394 V1244213 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_237312 V1244214 S NA 11FYY Cluster_557778 V1244215 S Pfam:DUF1200 1AKGE@sphNOG Cluster_540206 V1244216 WXCM S Domain-Containing protein 11PAN Cluster_6665 V1244218 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_271074 V1244219 METF map00670,map00720,map01100,map01120 E Methylenetetrahydrofolate reductase COG0685 Cluster_6684 V1244220 S NA 101UU Cluster_242549 V1244221 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_77134 V1244222 OCAR_6158 L Terminase, large subunit COG4626 Cluster_103437 V1244223 L Resolvase COG1961 Cluster_315355 V1244224 YIHY S ribonuclease BN COG1295 Cluster_275096 V1244225 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_135077 V1244226 YTOI K domain protein COG4109 Cluster_439030 V1244227 J acetyltransferase, (GNAT) family COG1670 Cluster_196983 V1244228 OCAR_7510 Q amidohydrolase COG1228 Cluster_173724 V1244229 YGHO S NA 1ANKF@spiNOG Cluster_223165 V1244230 CITC map02020 C (citrate (pro-3S)-lyase ligase COG3053 Cluster_715062 V1244231 S conjugative transposon protein TraQ 11SF8 Cluster_478004 V1244233 FOLA map00670,map00790,map01100 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) COG0262 Cluster_327619 V1244234 PPIA O PPIases accelerate the folding of proteins COG0652 Cluster_478005 V1244235 K transcriptional regulator, AsnC family COG1522 Cluster_718307 V1244236 L DNA packaging protein 123DA Cluster_157834 V1244237 ELI_1299 S Phage major capsid protein COG4653 Cluster_166164 V1244238 MSF G Major Facilitator COG0477 Cluster_708533 V1244239 S NA 11FE5 Cluster_108808 V1244241 YFNA E amino acid COG0531 Cluster_271075 V1244242 BMUL_0473 S ABC transporter, permease COG4120 Cluster_185577 V1244244 PRSA O Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) COG0760 Cluster_291317 V1244245 DPEP_1223 S Uroporphyrinogen decarboxylase (URO-D) 11M62 Cluster_215020 V1244246 map00680,map00860,map01100,map01110,map01120 H Methyltransferase MtaA CmuA family COG0407 Cluster_400052 V1244248 CASB S CRISPR system CASCADE complex protein CasB 0ZXJT Cluster_76431 V1244249 PGN_0103 S peptidase m56 0Y968 Cluster_247758 V1244250 S TPR COG0457 Cluster_283139 V1244251 S sialic acid-specific 9-O-acetylesterase 0XQ2Q Cluster_338159 V1244252 S Multi-copper polyphenol oxidoreductase laccase COG1496 Cluster_110064 V1244253 APEA map00480,map01100 E M18 family aminopeptidase COG1362 Cluster_60659 V1244254 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_272405 V1244255 SITC map02010,map02020 P ABC transporter COG1108 Cluster_618012 V1244256 BL00144 L Transposase COG2801 Cluster_610584 V1244257 BL00144 L Transposase COG2801 Cluster_303693 V1244258 V ABC transporter transmembrane region COG1132 Cluster_166894 V1244259 ULAA map00053,map01100,map01120,map02060 G PTS system ascorbate-specific transporter subunit IIC COG3037 Cluster_554873 V1244260 S NA 11THP Cluster_223166 V1244261 PDXY map00750,map01100 H Pyridoxal kinase COG2240 Cluster_99498 V1244263 V Mate efflux family protein COG0534 Cluster_332071 V1244264 S Methyltransferase 11PI2 Cluster_546056 V1244265 SP_0256 K acetyltransferase, (GNAT) family COG0454 Cluster_405429 V1244267 GPMB map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_242550 V1244268 TRXB map00240,map00450 O thioredoxin reductase COG0492 Cluster_57772 V1244269 S Arylsulfotransferase (ASST) 0XPAA Cluster_766327 V1244271 RBO C Superoxide reductase COG2033 Cluster_158702 V1244272 KBL map00260,map00780,map01100 E 2-amino-3-ketobutyrate coenzyme A ligase COG0156 Cluster_233720 V1244273 TDH G, M epimerase dehydratase COG0451 Cluster_391181 V1244275 CCPN K (CBS) domain COG0517 Cluster_291318 V1244276 YQFL S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) COG1806 Cluster_210496 V1244277 DGT map00230 F deoxyguanosinetriphosphate triphosphohydrolase-like protein COG0232 Cluster_534517 V1244279 MMDC map00061,map00253,map00620,map00640,map00720,map01100,map01110,map01120 I biotin lipoyl attachment domaiN-containing protein COG4770 Cluster_618013 V1244280 PAND map00410,map00770,map01100,map01110 H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) COG0853 Cluster_277728 V1244281 PANC map00410,map00770,map01100,map01110 H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) COG0414 Cluster_20153 V1244282 S NA 101UU Cluster_172900 V1244283 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_186495 V1244284 PURK map00230,map01100,map01110 F phosphoribosylaminoimidazole carboxylase atpase subunit COG0026 Cluster_482730 V1244285 PURE map00230,map01100,map01110 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) COG0041 Cluster_310757 V1244286 map00521,map00523,map01100,map01110 M dTDP-4-dehydrorhamnose 3,5-epimerase COG1898 Cluster_294055 V1244287 MODB map02010 P molybdate abc transporter COG4149 Cluster_136701 V1244288 S Inherit from COG: ATPase (AAA COG1373 Cluster_118410 V1244289 VAG V Mate efflux family protein COG0534 Cluster_534518 V1244291 YKII S NA 11GTZ Cluster_257746 V1244292 S NA 0Y7NW Cluster_110750 V1244293 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_360452 V1244294 SSCG_03030 map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_172901 V1244295 M RND family efflux transporter COG0845 Cluster_107063 V1244296 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_108809 V1244297 CBIK map00860,map01100 H cobalt chelatase COG4822 Cluster_209417 V1244298 COBD map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01230 E decarboxylase COG0079 Cluster_385923 V1244299 CASB S CRISPR system CASCADE complex protein CasB 0ZXJT Cluster_489685 V1244300 O DnaJ domain protein 1297B Cluster_52829 V1244302 M cell wall-binding protein COG2247 Cluster_41700 V1244303 PABB map00400,map00790,map01100,map01110,map01230 E, H synthase COG0512 Cluster_307888 V1244304 AROF map00400,map01100,map01110,map01230 E phospho-2-dehydro-3-deoxyheptonate aldolase COG2876 Cluster_144982 V1244305 SERB map00260,map00680,map01100,map01120,map01230 E phosphoserine phosphatase COG3830 Cluster_338160 V1244306 YFKO C Nitroreductase COG0778 Cluster_537407 V1244308 S NA 12AGZ Cluster_416180 V1244310 RPOE map00230,map00240,map01100,map03020 K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity) COG3343 Cluster_326064 V1244311 SRTB U sortase, SrtB family COG4509 Cluster_451040 V1244313 S hemerythrin hhe cation binding domain protein COG3945 Cluster_313770 V1244314 GUFA P Mediates zinc uptake. May also transport other divalent cations (By similarity) COG0428 Cluster_543105 V1244315 C Flavodoxin COG0716 Cluster_398318 V1244316 K Transcriptional regulator, TetR family 128VI Cluster_644918 V1244317 DNAG map03030 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 Cluster_207249 V1244318 DGT map00230 F deoxyguanosinetriphosphate triphosphohydrolase-like protein COG0232 Cluster_482731 V1244319 OPPF map02010 E, P ABC transporter, ATP-binding protein COG4608 Cluster_217352 V1244320 APPD map02010 E, P ABC transporter COG0444 Cluster_53285 V1244321 BA_0233 P abc transporter, permease COG1173 Cluster_61815 V1244322 S p-loop domain protein COG4928 Cluster_113513 V1244323 S S-layer homology domain 0Y0KZ Cluster_909131 V1244324 Q isochorismatase COG1335 Cluster_89978 V1244325 S NA 0YCKF Cluster_18505 V1244328 S fad dependent oxidoreductase COG2509 Cluster_16443 V1244329 S NA 11QZ9 Cluster_392992 V1244330 FCHA map00670,map01100 E Methenyltetrahydrofolate cyclohydrolase COG3404 Cluster_176965 V1244331 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_131135 V1244332 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_117720 V1244333 GLUP G transporter COG0738 Cluster_71831 V1244334 SGLY_0562 S NA 0ZU6E Cluster_350593 V1244337 J rrna methyltransferase COG0566 Cluster_475810 V1244338 CTSR K transcriptional regulator, ctsr COG4463 Cluster_199908 V1244340 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_302245 V1244341 SUFC O feS assembly ATPase SufC COG0396 Cluster_166165 V1244342 TAGO M Glycosyl transferase, family 4 COG0472 Cluster_449071 V1244343 L decarboxylase COG1611 Cluster_708534 V1244344 S von Willebrand factor COG1721 Cluster_228950 V1244345 S Uncharacterized protein conserved in bacteria (DUF2179) COG1284 Cluster_176152 V1244346 S NA 0ZBRU Cluster_68569 V1244347 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_10236 V1244348 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_288725 V1244349 MENB map00130,map01100,map01110 H Naphthoate synthase COG0447 Cluster_67152 V1244350 MEND map00130,map01100,map01110 H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) COG1165 Cluster_231294 V1244351 GLK map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G Glucokinase COG1940 Cluster_621661 V1244352 RPLS map03010 J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) COG0335 Cluster_255230 V1244353 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate (By similarity) COG0167 Cluster_326065 V1244354 PYRK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) COG0543 Cluster_262987 V1244355 PYRF map00240,map00983,map01100 F orotidine 5''-phosphate decarboxylase COG0284 Cluster_540207 V1244356 PYRI map00240,map00250,map01100 F Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) COG1781 Cluster_917683 V1244357 RPSP map03010 J 30s ribosomal protein S16 COG0228 Cluster_189899 V1244359 G ABC transporter integral membrane protein COG1172 Cluster_110751 V1244360 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_101704 V1244361 S Membrane COG1808 Cluster_414411 V1244363 CBIE map00860,map01100 H Precorrin-6Y C5,15-methyltransferase (Decarboxylating), CbiE subunit COG2241 Cluster_192615 V1244364 CBID map00860,map01100,map02010 H May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) COG1903 Cluster_392993 V1244365 COBH map00860,map01100 H Precorrin-8x methylmutase COG2082 Cluster_509967 V1244366 SMPB O Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) COG0691 Cluster_592739 V1244367 K dependent repressor COG1321 Cluster_657205 V1244368 map00350,map00362,map00627,map00642,map00903,map01120 S -acetyltransferase COG2388 Cluster_531726 V1244369 S NA 12CCP Cluster_117721 V1244370 S NA 11R7X Cluster_251549 V1244371 S NA 122YS Cluster_350594 V1244372 PURC map00230,map01100,map01110 F Phosphoribosylaminoimidazolesuccinocarboxamide synthase COG0152 Cluster_367051 V1244373 MGTC S MgtC SapB transporter COG1285 Cluster_288726 V1244374 S NA 0Y91I Cluster_227783 V1244375 YQJA S Membrane COG4129 Cluster_174540 V1244376 P permease COG0628 Cluster_162897 V1244378 YTFP S hi0933 family COG2081 Cluster_60395 V1244379 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 Cluster_269766 V1244380 K Transcriptional Regulator AraC Family COG2207 Cluster_98975 V1244381 BGLB map00010 G Glycosyl hydrolase family 1 COG2723 Cluster_9363 V1244382 CSN1 L CRISPR-associated protein, Csn1 family COG3513 Cluster_260380 V1244384 ASPB map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aminotransferase COG0436 Cluster_142782 V1244385 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_683297 V1244386 YLXP S Protein of unknown function (DUF503) COG1550 Cluster_380603 V1244387 NTH map03410 L endonuclease III COG0177 Cluster_128909 V1244388 RARA L recombination factor protein RarA COG2256 Cluster_507362 V1244389 NRDR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) COG1327 Cluster_142004 V1244390 GLTS E Sodium Glutamate Symporter COG0786 Cluster_38678 V1244391 YQFF S Metal Dependent Phosphohydrolase COG1480 Cluster_277729 V1244392 MALD map02010 P ABC transporter, permease COG3833 Cluster_130356 V1244393 MALC map02010 P permease protein COG1175 Cluster_67896 V1244394 L adenine specific DNA methylase COG2189 Cluster_324568 V1244396 SPOU J rrna methyltransferase COG0566 Cluster_371998 V1244397 KTRA P domain protein COG0569 Cluster_523233 V1244398 M acetyltransferase COG1247 Cluster_412530 V1244399 V Mate efflux family protein COG0534 Cluster_75470 V1244400 CBC4_0930 L Transposase COG3666 Cluster_546057 V1244401 LDTA S ErfK YbiS YcfS YnhG COG1376 Cluster_83402 V1244402 HUTH map00340,map01100 E Histidine ammonia-lyase COG2986 Cluster_264370 V1244403 FTCD map00340,map00670,map01100 E Glutamate formiminotransferase COG3643 Cluster_515233 V1244404 SMPB O Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) COG0691 Cluster_61816 V1244405 FBPA K Fibronectin-binding protein COG1293 Cluster_271076 V1244406 M hydrolase, family 25 COG3757 Cluster_405430 V1244407 PCP O Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) COG2039 Cluster_335081 V1244408 C Cysteine-rich domain protein COG0247 Cluster_247759 V1244409 S Membrane 0XRRH Cluster_367052 V1244410 S peptidase family M49 0XRK4 Cluster_400053 V1244411 S HAD hydrolase, family IA, variant 3 COG1011 Cluster_95713 V1244412 L Domain protein COG0507 Cluster_147303 V1244413 S NA 0XWFB Cluster_174541 V1244416 U type ii secretion system 11ZC3 Cluster_90919 V1244417 PURF map00230,map00250,map01100,map01110 F glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_247760 V1244418 T Histidine kinase COG0642 Cluster_357120 V1244419 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_77823 V1244420 V abc transporter permease protein 0ZW5X Cluster_126810 V1244421 S sodium dicarboxylate symporter COG1823 Cluster_606928 V1244422 RSFS S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) COG0799 Cluster_436992 V1244424 S Domain of unknown function (DUF3332) 11RNE Cluster_447057 V1244425 S Possible lysine decarboxylase COG1611 Cluster_507363 V1244426 K Iron dependent repressor, N-terminal DNA binding domain COG1846 Cluster_201895 V1244427 P Phosphate-Selective Porin O and P 0YHCG Cluster_549094 V1244428 HSP20 map04141 O Heat shock protein COG0071 Cluster_489686 V1244429 S NA 0Y6PA Cluster_781219 V1244430 LKTB V ABC transporter, ATP-binding protein COG2274 Cluster_68223 V1244431 M Sulfatase COG1368 Cluster_165356 V1244432 YWBD S Methyltransferase COG1092 Cluster_11535 V1244433 S Rib/alpha-like repeat 10008 Cluster_480412 V1244434 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0847 Cluster_300867 V1244435 TRMB S Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_197921 V1244436 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E brancheD-chain amino acid aminotransferase COG0115 Cluster_138251 V1244437 HUTI map00340,map01100 Q imidazolone-5-propionate hydrolase COG1228 Cluster_144232 V1244438 Y2367 P integral membrane protein COG4393 Cluster_352096 V1244439 P19 P Periplasmic Protein COG3470 Cluster_398319 V1244440 INT S 'Phage' integrase family 0YKE0 Cluster_517909 V1244441 RPLM map03010 J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) COG0102 Cluster_348973 V1244442 VICR map02020 T Two component transcriptional regulator (Winged helix family COG0745 Cluster_56252 V1244443 VICK map02020 T Histidine kinase 0XNMH Cluster_820841 V1244444 map03070 S NA 122A7 Cluster_449072 V1244445 METG J emap domain COG0073 Cluster_146526 V1244446 L site-specific recombinase, phage integrase family COG0582 Cluster_53054 V1244447 MUTL map03430 L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) COG0323 Cluster_185578 V1244448 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_537408 V1244449 NUSB K Involved in the transcription termination process (By similarity) COG0781 Cluster_543106 V1244450 ASP S alkaline shock protein COG1302 Cluster_433017 V1244451 EFP J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) COG0231 Cluster_194434 V1244452 PEPQ map00310,map00780,map01100 E peptidase M24 COG0006 Cluster_202941 V1244453 LDCA V peptidase U61 LD-carboxypeptidase A COG1619 Cluster_447058 V1244454 S NA 0XYT7 Cluster_523234 V1244456 NTPF S H -ATPase, subunit H 122TR Cluster_485048 V1244457 COAD map00770,map01100 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) COG0669 Cluster_389452 V1244458 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_131904 V1244459 HFLX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COG2262 Cluster_154465 V1244462 S NA 0ZR2U Cluster_352097 V1244463 PHOB map02020 T Response regulator receiver domain protein COG0745 Cluster_509968 V1244465 NRDI F NrdI protein COG1780 Cluster_336613 V1244467 L Pfam:Transposase_12 0ZKF2 Cluster_407095 V1244469 RECU S Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) COG3331 Cluster_33754 V1244470 PBP1A map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_820842 V1244471 S Toxin-antitoxin system, toxin component, HicA family 0XUD5 Cluster_543107 V1244472 S Toxin-antitoxin system, antitoxin component, HicB family 12518 Cluster_342561 V1244473 S Membrane COG1811 Cluster_416181 V1244474 YJJG map00230,map00240,map00361,map00625,map00760,map01100,map01110,map01120 S Hydrolase COG1011 Cluster_458926 V1244475 PYRR map00240,map01100 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) COG2065 Cluster_137487 V1244476 PYRP F permease COG2233 Cluster_254020 V1244477 PARB K parb-like partition protein COG1475 Cluster_313771 V1244478 S NA 11QPY Cluster_171983 V1244479 MLTD M Lytic Murein transglycosylase COG0741 Cluster_128193 V1244482 YAAT S psp1 domain protein COG1774 Cluster_43894 V1244483 AMIA map02010 E Oligopeptide-binding protein COG4166 Cluster_793115 V1244484 S fad dependent oxidoreductase COG2509 Cluster_436993 V1244485 LEPB map03060 U Signal peptidase i COG0681 Cluster_162063 V1244486 map02020 T Histidine kinase COG0642 Cluster_357121 V1244487 PHOP map02020 T response regulator 11FPD Cluster_492187 V1244488 FOLA map00670,map00790,map01100 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) COG0262 Cluster_250330 V1244490 SPOIID D SpoIID LytB domain protein COG2385 Cluster_208376 V1244491 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_17709 V1244492 S NA 0YD1F Cluster_589370 V1244496 GLOA map00620,map04011 E Lactoylglutathione lyase COG0346 Cluster_360453 V1244497 ATPD map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG1394 Cluster_103438 V1244498 map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) COG1156 Cluster_306583 V1244499 YLME F alanine racemase domain protein COG0325 Cluster_108195 V1244500 ATPB map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) COG1156 Cluster_394819 V1244501 S Conjugative transposon TraK protein 0YYBW Cluster_256459 V1244503 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_573283 V1244504 CDD map00240,map00983,map01100,map05219 F cytidine deaminase COG0295 Cluster_108196 V1244505 GLMU map00520,map01100,map01110 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) COG1207 Cluster_14639 V1244506 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_633004 V1244508 K Helix-turn-helix domain, rpiR family COG1737 Cluster_573284 V1244509 K TRANSCRIPTIONAl REGULATOR GntR family COG1725 Cluster_139791 V1244511 S Phospholipase D endonuclease domain-containing protein 0Z3N0 Cluster_102268 V1244512 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_429037 V1244513 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_295462 V1244514 S NA 11Z9D Cluster_9939 V1244515 S NA 0ZTYV Cluster_9940 V1244516 S NA 0ZTYV Cluster_431020 V1244517 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_199909 V1244518 HRCA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) COG1420 Cluster_28569 V1244520 S NA 0ZQAG Cluster_382379 V1244521 V (ABC) transporter COG1131 Cluster_502376 V1244523 S NA 0XY2M Cluster_47873 V1244524 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_433018 V1244525 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_478007 V1244526 NRDG O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) COG0602 Cluster_35837 V1244527 F ATP cone domain COG1328 Cluster_234914 V1244529 S radical SAM domain protein COG0535 Cluster_633005 V1244530 map00362,map01100,map01120 S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) 11M0H Cluster_206153 V1244531 MBL D Rod shape-determining protein mreb COG1077 Cluster_111438 V1244533 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_135890 V1244534 S NA 0ZE8A Cluster_21493 V1244535 PCRA map03420,map03430 L helicase COG0210 Cluster_429038 V1244536 MTGA map00550 M Monofunctional biosynthetic peptidoglycan transglycosylase COG0744 Cluster_641038 V1244537 UBIE map00340,map00350,map00624,map01120 Q methyltransferase COG0500 Cluster_262988 V1244538 PHZF S phenazine biosynthesis protein, phzf family COG0384 Cluster_291319 V1244539 PARB K parb-like partition protein COG1475 Cluster_306584 V1244540 SOJ D Chromosome Partitioning Protein COG1192 Cluster_436994 V1244541 PURA map00230,map00250,map01100 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis COG0104 Cluster_30354 V1244542 GSHA map00480,map01100 H gamma-glutamylcysteine synthetase COG2918 Cluster_128910 V1244544 FLGJ N, U flagellar rod assembly protein muramidase flgj COG1705 Cluster_487338 V1244547 MUTX L mutator MutT protein COG0494 Cluster_731569 V1244548 S Protein of unknown function (DUF3343) 0XTWJ Cluster_135078 V1244549 E 2-hydroxyglutaryl-CoA dehydratase COG1775 Cluster_805223 V1244550 S NA 0Y39F Cluster_705441 V1244551 D, J addiction module toxin, RelE StbE family COG2026 Cluster_467273 V1244556 S Recombinase 0Y2JQ Cluster_238629 V1244557 S YbbR-like protein COG4856 Cluster_97890 V1244558 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_60396 V1244559 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_368661 V1244561 PYRE map00240,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_344158 V1244565 GLPF G Major Intrinsic Protein COG0580 Cluster_419763 V1244566 DHAL map00561,map01100 G Dihydroxyacetone kinase COG2376 Cluster_260381 V1244568 CYSK map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_439031 V1244569 CYSE map00270,map00920,map01100,map01120,map01230 E serine acetyltransferase COG1045 Cluster_429039 V1244570 RPLJ map03010 J 50s ribosomal protein L10 COG0244 Cluster_678756 V1244571 RPSJ map03010 J Involved in the binding of tRNA to the ribosomes (By similarity) COG0051 Cluster_400054 V1244572 RPLC map03010 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 Cluster_391182 V1244573 RPLD map03010 J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) COG0088 Cluster_520477 V1244574 RPLW map03010 J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) COG0089 Cluster_261694 V1244575 FABD map00061,map01100 I malonyl CoA-acyl carrier protein transacylase COG0331 Cluster_163708 V1244576 ACTP P copper-exporting ATPase COG2217 Cluster_387749 V1244577 YTFE D Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) COG2846 Cluster_625462 V1244578 CLOLE_0797 S NA 11N1T Cluster_262989 V1244579 CLOLE_0796 L recT protein COG3723 Cluster_280393 V1244581 PI346 L dna replication protein COG1484 Cluster_256461 V1244583 S AP2 domain 123DH Cluster_127505 V1244584 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_478008 V1244585 RPSE map03010 J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) COG0098 Cluster_79160 V1244586 RNE map03018 J ribonuclease COG1530 Cluster_517910 V1244587 G YhcH YjgK YiaL family protein COG2731 Cluster_256462 V1244588 K transcriptional regulator 124NK Cluster_528907 V1244589 YQEY S gatB Yqey COG1610 Cluster_310758 V1244590 ZUPT P Mediates zinc uptake. May also transport other divalent cations (By similarity) COG0428 Cluster_625463 V1244592 S NA 0YW7X Cluster_117722 V1244593 S NA 0YCS2 Cluster_327620 V1244595 KDSB map00540,map01100 M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) COG1212 Cluster_251550 V1244597 map00430,map00620,map00640,map00650,map00680,map00720,map01100,map01120 C phosphate COG0280 Cluster_190756 V1244598 BUK map00650,map01100 C Branched-chain carboxylic acid kinase COG3426 Cluster_312273 V1244599 YLMH J s4 domain protein COG2302 Cluster_517911 V1244600 LSPA map03060 M, U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) COG0597 Cluster_363598 V1244601 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_256463 V1244602 RLUD J Pseudouridine synthase COG0564 Cluster_165357 V1244605 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_425220 V1244606 LEMA S LemA family COG1704 Cluster_63753 V1244607 S Domain of unknown function DUF87 COG0433 Cluster_183819 V1244608 S hexapeptide transferase family protein 0ZWTP Cluster_327621 V1244609 PORT S porT protein 11H7K Cluster_291320 V1244610 USHA F 5-nucleotidase COG0737 Cluster_551978 V1244611 K Sigma factor 0YGB2 Cluster_134287 V1244612 S Inherit from NOG: Phosphate-Selective Porin O and P 0XQB1 Cluster_471550 V1244613 S NA 0YSBG Cluster_27187 V1244614 S NA 0ZJP4 Cluster_58547 V1244615 PEPP E peptidase, M24 COG0006 Cluster_268426 V1244616 YITS S degv family COG1307 Cluster_554874 V1244617 MRNC S Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) COG1939 Cluster_107064 V1244618 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_431021 V1244619 L NUDIX hydrolase COG0494 Cluster_223167 V1244621 S Methyltransferase 11REP Cluster_299481 V1244622 PPNK map00760,map01100 G Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) COG0061 Cluster_330513 V1244623 map00340,map01100,map01110,map01230 E histidinol phosphate phosphatase, hisj family COG1387 Cluster_250331 V1244624 S NA 10255 Cluster_489687 V1244625 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_347366 V1244626 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_434933 V1244627 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_363599 V1244628 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_213831 V1244629 METN map02010 P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COG1135 Cluster_378878 V1244630 METI map02010 P ABC transporter, permease COG2011 Cluster_275097 V1244631 METQ map02010 P (Lipo)protein COG1464 Cluster_644919 V1244632 T transcriptional modulator of maze toxin, mazf COG2337 Cluster_287362 V1244633 MSCS M mechanosensitive ion channel COG0668 Cluster_475811 V1244634 YWHH S ybak prolyl-trna synthetase associated region COG2606 Cluster_414412 V1244635 O Redoxin 0ZW36 Cluster_231295 V1244636 IUNH map00230,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_439032 V1244637 S integral membrane protein 0ZXN5 Cluster_172902 V1244639 GSPE map03070 U type ii secretion system protein e COG2804 Cluster_145732 V1244640 YEGQ map05120 O Peptidase U32 COG0826 Cluster_537409 V1244641 RUSA L endodeoxyribonuclease RusA COG4570 Cluster_295463 V1244643 CLOLE_0797 S NA 11N1T Cluster_260382 V1244645 RLUD2 J pseudouridine synthase COG0564 Cluster_396594 V1244646 ISAA M Is able to cleave peptidoglycan (By similarity) 12D4Q Cluster_344159 V1244651 S NA 121DX Cluster_669907 V1244657 YRZB S UPF0473 protein COG3906 Cluster_543108 V1244658 RUVX L Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) COG0816 Cluster_692223 V1244659 YRZL S UPF0297 protein COG4472 Cluster_242551 V1244662 RESA2 O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG0526 Cluster_797091 V1244663 G transporter 0XPWC Cluster_52365 V1244665 M Cell wall anchor domain protein 11Q8J Cluster_207250 V1244666 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_272406 V1244667 STRIC_0432 L Transposase (IS4 family 11HCS Cluster_71832 V1244669 E Dipeptidase COG4690 Cluster_30234 V1244671 FTSI map00550,map01100 M penicillin-binding protein COG0768 Cluster_641040 V1244672 YACP J Tetracycline resistance protein COG3688 Cluster_333582 V1244673 RLMB map00340,map00350,map00624,map01120 J RNA methyltransferase TrmH family group 3 COG0566 Cluster_97891 V1244674 AMYA map00500,map01100,map04973 G Alpha-amylase COG0366 Cluster_648997 V1244675 YAAK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) COG0718 Cluster_419764 V1244676 RECR map03440 L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) COG0353 Cluster_322986 V1244677 MURI map00230,map00240,map00471,map01100 M Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) COG0796 Cluster_201896 V1244678 FNI map00900,map01100,map01110 C Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) COG1304 Cluster_100571 V1244679 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_546059 V1244680 MRNC S Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) COG1939 Cluster_327622 V1244681 RLMB map00340,map00350,map00624,map01120 J RNA methyltransferase TrmH family group 3 COG0566 Cluster_167697 V1244682 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_434934 V1244684 FOLE map00790,map01100 H GTP cyclohydrolase i COG0302 Cluster_489688 V1244685 S domain protein COG1418 Cluster_292674 V1244686 FOLK map00790,map01100 H 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase COG1539 Cluster_427141 V1244687 FLGJ map00511 N, U flagellar rod assembly protein muramidase flgj COG1705 Cluster_157835 V1244688 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_515234 V1244689 NIFU C FeS cluster assembly scaffold protein NifU COG0822 Cluster_152896 V1244690 P permease COG0628 Cluster_637050 V1244691 HIMA L DNA-binding protein Hu 123YW Cluster_128194 V1244692 RIMO J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) COG0621 Cluster_596209 V1244693 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_101705 V1244694 GND map00030,map00480,map01100,map01110,map01120 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) COG0362 Cluster_357122 V1244695 ARLR map02020 T response regulator COG0745 Cluster_139007 V1244696 S repeat protein COG0457 Cluster_60967 V1244697 GLNS map00970,map01100 J glutaminyL-tRNA synthetase COG0008 Cluster_251551 V1244700 CYSE map00270,map00920,map01100,map01120,map01230 E serine acetyltransferase COG1045 Cluster_271077 V1244701 K transcriptional regulator, arac family 11ZDW Cluster_396595 V1244702 S Protein of unknown function (DUF3109) 0XQ9F Cluster_109441 V1244705 NHAC-1 map00680 C Na H antiporter COG1757 Cluster_170344 V1244706 S transporter gate domain protein 0XRV8 Cluster_365340 V1244707 map02010 P Cobalt transport protein COG0619 Cluster_824820 V1244708 RPMG map03010 J 50S ribosomal protein L33 1250Q Cluster_728266 V1244709 RPMB map03010 J 50s ribosomal protein l28 COG0227 Cluster_471551 V1244710 CINA H competence damage-inducible protein COG1546 Cluster_203988 V1244711 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_400055 V1244712 K Transcriptional regulator, TetR family 0XUF9 Cluster_280394 V1244713 TCMP map00340,map00350,map00624,map01120 Q O-Methyltransferase COG3315 Cluster_785325 V1244714 P domain protein 101JI Cluster_751604 V1244715 FEOA P Ferrous iron transport protein A COG1918 Cluster_34202 V1244716 FEOB P Ferrous iron transport protein b COG0370 Cluster_392994 V1244718 map02010 P ABC transporter (Permease COG0601 Cluster_133492 V1244719 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_702341 V1244720 S NA 0YFZU Cluster_26675 V1244721 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_499844 V1244722 SMPB O Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) COG0691 Cluster_220833 V1244723 DHAK map00561,map00680,map01100,map01120,map04622 G Dihydroxyacetone kinase COG2376 Cluster_130357 V1244724 PURB map00230,map00250,map01100,map01110 F adenylosuccinate lyase COG0015 Cluster_291321 V1244725 PEPS E aminopeptidase COG2309 Cluster_119139 V1244726 PYCB map00330,map00620,map01100 C Oxaloacetate decarboxylase COG5016 Cluster_469391 V1244727 YPSC L Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) COG0116 Cluster_586066 V1244728 SORA C Superoxide reductase COG2033 Cluster_149596 V1244729 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_302246 V1244730 M Export protein 11MRX Cluster_52366 V1244731 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_87271 V1244732 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_407096 V1244733 PURN map00230,map00670,map01100,map01110 F phosphoribosylglycinamide formyltransferase COG0299 Cluster_121404 V1244734 FTSW D cell cycle protein COG0772 Cluster_37803 V1244735 PEPO O Endothelin-converting enzyme 1 COG3590 Cluster_335082 V1244736 NTH map03410 L endonuclease III COG0177 Cluster_371999 V1244737 S NA 12D34 Cluster_156968 V1244739 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_618015 V1244740 RPLT map03010 J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) COG0292 Cluster_817008 V1244741 RPMI map03010 J 50s ribosomal protein L35 COG0291 Cluster_586067 V1244742 INFC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) COG0290 Cluster_88124 V1244743 V ABC transporter COG1132 Cluster_30355 V1244744 ZNTA P copper-exporting ATPase COG2217 Cluster_307889 V1244746 DIVIVA D Cell division protein DIVIVA COG3599 Cluster_355426 V1244750 YEAZ O Peptidase M22 Glycoprotease COG1214 Cluster_385924 V1244751 S NA 11FTP Cluster_242552 V1244753 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_661415 V1244755 YBJQ S UPF0145 protein COG0393 Cluster_252773 V1244756 RNFB C electron transport complex, RnfABCDGE type, B subunit COG2878 Cluster_110065 V1244757 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_12878 V1244758 S NA 0YZ82 Cluster_23201 V1244759 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_39800 V1244761 S domain protein 12C1H Cluster_606929 V1244762 RNPA J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) COG0594 Cluster_294056 V1244763 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins COG0706 Cluster_592740 V1244764 UMUD K, T UmuD protein COG1974 Cluster_130358 V1244765 UMUC L DNA polymerase COG0389 Cluster_205068 V1244766 map02010 P periplasmic binding protein COG0614 Cluster_579626 V1244767 YQEK map00760,map01100 H Metal Dependent Phosphohydrolase COG1713 Cluster_138252 V1244768 S Membrane 11KXQ Cluster_277730 V1244769 GLPF G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) COG0580 Cluster_195313 V1244770 P Na Pi-cotransporter COG1283 Cluster_152897 V1244771 G Major facilitator superfamily MFS_1 COG0477 Cluster_718309 V1244772 S NA 11VTP Cluster_119140 V1244775 CSHB map03018 L ATP-dependent RNA helicase COG0513 Cluster_447059 V1244776 S Rhodanese domain protein 11KPM Cluster_321422 V1244777 S NA 11FFJ Cluster_867994 V1244778 L Transposase 11M0T Cluster_171984 V1244780 M phage lysin (EC 3.2.1.17) COG1388 Cluster_781221 V1244781 UBIE map00130,map01100,map01110 H Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) COG2226 Cluster_298201 V1244782 MREC M Involved in formation and maintenance of cell shape (By similarity) COG1792 Cluster_352098 V1244783 SP_1668 S TIGR02206 family 11T9J Cluster_766328 V1244784 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_295464 V1244785 ECFT map02010 P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) COG0619 Cluster_273738 V1244786 ECFA2 map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_281731 V1244787 ECFA1 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_332072 V1244788 map00330,map01100 S Carbon-nitrogen hydrolase 11WGJ Cluster_494666 V1244789 S Resistance protein COG3467 Cluster_534519 V1244790 L DNA alkylation repair enzyme COG4912 Cluster_267011 V1244791 LIVH map02010 E branched-chain amino acid ABC transporter, permease COG0559 Cluster_234915 V1244792 LIVM map02010 E branched-chain amino acid ABC transporter, permease COG4177 Cluster_160398 V1244793 RECX map00561,map01100 M Glycosyl transferase (Group 1 COG0438 Cluster_403615 V1244794 S DNA alkylation repair enzyme 11MSB Cluster_832367 V1244796 S NA 128KH Cluster_176966 V1244797 L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) COG0582 Cluster_596210 V1244798 S NA 122EK Cluster_114226 V1244800 V Mate efflux family protein COG0534 Cluster_197922 V1244801 P ABC transporter substrate-binding protein 0XTCH Cluster_113514 V1244802 P Na Pi-cotransporter COG1283 Cluster_499845 V1244803 TRML map04122 J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) COG0219 Cluster_259076 V1244804 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_125420 V1244806 LYSC map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Aspartokinase COG0527 Cluster_315356 V1244807 FTSE map02010 D Cell division ATP-binding protein ftsE COG2884 Cluster_478009 V1244810 S NA 11X1V Cluster_306585 V1244811 S NA 12C87 Cluster_582873 V1244812 GCVH map00630,map01110 E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) COG0509 Cluster_182999 V1244813 GCVT map00260,map00670,map00910,map01100 E The glycine cleavage system catalyzes the degradation of glycine (By similarity) COG0404 Cluster_271078 V1244814 YHBJ S Displays ATPase and GTPase activities (By similarity) COG1660 Cluster_227784 V1244815 YBHK S UPF0052 protein COG0391 Cluster_378879 V1244816 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_143479 V1244817 HFLX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COG2262 Cluster_188196 V1244819 S Phage-Associated Protein COG3600 Cluster_439033 V1244820 PDXT map00750 H Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) COG0311 Cluster_526144 V1244821 map00190,map00680,map01100 C ATP synthase subunit C 11URT Cluster_665627 V1244822 map00190,map00680,map01100 C ATP synthase, subunit F 124BE Cluster_384144 V1244823 map00190,map00680,map01100 C subunit e 0Y1FS Cluster_515235 V1244824 ATPA map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) COG1155 Cluster_563819 V1244825 S Membrane bound regulatory protein 12CIW Cluster_445007 V1244826 OGT L Methyltransferase COG0350 Cluster_37494 V1244829 RRGB M Lpxtg-motif cell wall anchor domain protein 0XSEP Cluster_603294 V1244831 NOX map00190 P pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_80974 V1244832 ERIC P Chloride channel COG0038 Cluster_196163 V1244833 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_171985 V1244834 TGT J Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COG0343 Cluster_629154 V1244835 YAJC map03060,map03070 U preprotein translocase, subunit YajC COG1862 Cluster_653076 V1244838 S NA 12481 Cluster_512540 V1244839 XRE K Transcriptional regulator COG1396 Cluster_151227 V1244841 NATB C, P ABC transporter, permease COG1668 Cluster_60660 V1244842 map02010 V ABC transporter COG1132 Cluster_70243 V1244843 PGCA map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_433019 V1244844 K MarR family 1251S Cluster_389453 V1244845 FEMX map00550,map01100 V Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor (By similarity) COG2348 Cluster_281732 V1244847 HBD map00360,map00362,map00650,map01100,map01120 I 3-hydroxyacyl-CoA dehydrogenase COG1250 Cluster_312274 V1244848 CRT map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00630,map00640,map00650,map00720,map00903,map00930,map01100,map01110,map01120 I 3-hydroxybutyryl-CoA dehydratase COG1024 Cluster_291322 V1244849 PEAH map02010 V ABC transporter transmembrane region COG1132 Cluster_357123 V1244850 K Helix-turn-helix type 11 domain protein COG2378 Cluster_350595 V1244851 map00770 H 4'-phosphopantetheinyl transferase COG2091 Cluster_537410 V1244852 S domain protein 0XNZW Cluster_439034 V1244854 UBIE map00130,map01100,map01110 H Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) COG2226 Cluster_766329 V1244855 DCK map00230,map00240,map01100 F deoxynucleoside kinase COG1428 Cluster_73866 V1244856 G transporter major facilitator family protein 0XRD8 Cluster_227785 V1244857 GLPX map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120 G Fructose-1,6-bisphosphatase COG1494 Cluster_384145 V1244858 TAL map00030,map01100,map01110,map01120,map01230 G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) COG0176 Cluster_302247 V1244859 S Nitroreductase 11QVA Cluster_502377 V1244860 S NA 11SFV Cluster_179514 V1244862 OADB map00330,map00620,map01100 C decarboxylase (Beta subunit) COG1883 Cluster_751606 V1244865 RIML J acetyltransferase, (GNAT) family COG1670 Cluster_436995 V1244866 ALD map00250,map00430,map01100 E alanine dehydrogenase COG0686 Cluster_793118 V1244867 PHOH T Phoh family COG1702 Cluster_296808 V1244868 S NA 11NX4 Cluster_412531 V1244869 map00521,map00523,map01100,map01110 M dTDP-4-dehydrorhamnose 3,5-epimerase COG1898 Cluster_269767 V1244870 RFBA map00521,map00523,map01100,map01110 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) COG1209 Cluster_497177 V1244871 L Nudix family COG0494 Cluster_362030 V1244872 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_55759 V1244873 map00270,map01100 L C-5 cytosine-specific DNA methylase COG0270 Cluster_367053 V1244874 G, M Nucleoside-diphosphate-sugar epimerase COG0702 Cluster_828617 V1244875 G, M Nucleoside-diphosphate-sugar epimerase COG0702 Cluster_157836 V1244876 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_443019 V1244877 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_523235 V1244878 RPLK map03010 J This protein binds directly to 23S ribosomal RNA (By similarity) COG0080 Cluster_345772 V1244879 DEOD map00230,map00240,map00270,map00760,map01100,map01110 F purine nucleoside phosphorylase DeoD-type COG0813 Cluster_322987 V1244880 CSM6 S CRISPR-associated protein, Csm6 11FCG Cluster_15105 V1244881 S NA 0YZ82 Cluster_103439 V1244883 S NA 17D7N@proNOG Cluster_182098 V1244884 S mobilization protein 0XWI1 Cluster_394820 V1244885 GGC_1888 S NA 0ZAYP Cluster_170345 V1244888 TONB M TonB family 11HUD Cluster_398320 V1244889 O Pyruvate formate-lyase COG1180 Cluster_463100 V1244890 S conserved protein domain typically associated with flavoprotein COG1853 Cluster_433020 V1244891 P Chromate COG2059 Cluster_449073 V1244892 CHRA P Chromate COG2059 Cluster_305198 V1244893 ZURM map02010 P ABC, transporter COG1108 Cluster_373617 V1244894 ADCC map02010 P ABC transporter COG1121 Cluster_182099 V1244895 ADCA map02010 P periplasmic solute binding protein COG0803 Cluster_80975 V1244896 AHPF O Alkyl hydroperoxide reductase COG3634 Cluster_487339 V1244897 LUXS map00270,map05111 T Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) COG1854 Cluster_718312 V1244898 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_167698 V1244899 NAGA map00052,map00520,map01110 G GlcNAc 6-P deacetylase COG1820 Cluster_368662 V1244900 LSPA map03060 U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) 11G1Y Cluster_579627 V1244901 DKSA S DnaK suppressor protein 11IHW Cluster_345773 V1244902 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG2812 Cluster_401838 V1244903 map00730,map01100 H Thiamine monophosphate synthase 11FJG Cluster_239901 V1244904 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Ribose-phosphate pyrophosphokinase COG0462 Cluster_224352 V1244905 K AraC Family Transcriptional Regulator COG2207 Cluster_384146 V1244906 TRMB C Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_210497 V1244907 BIOB map00780,map01100 H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) COG0502 Cluster_425223 V1244908 XPT map00230,map01100,map01110 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) COG0503 Cluster_65398 V1244909 PGCA map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_338161 V1244910 S Filamentation induced by cAMP protein fic COG3177 Cluster_711678 V1244913 YAFQ S addiction module toxin, RelE StbE family COG3041 Cluster_718313 V1244914 L Addiction module antitoxin, RelB DinJ family COG3077 Cluster_507364 V1244915 YJEE S protein family UPF0079, ATPase COG0802 Cluster_365341 V1244916 YEAZ O Peptidase M22 Glycoprotease COG1214 Cluster_528908 V1244917 RIMI O ribosomal-protein-alanine acetyltransferase COG0456 Cluster_216156 V1244918 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_116305 V1244919 RNFC C Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) COG4656 Cluster_262990 V1244920 YPJC S YitT family COG1284 Cluster_357124 V1244921 S Amino terminal protease 11T6A Cluster_443020 V1244922 FTHC map00670,map01100 H 5-formyltetrahydrofolate cyclo-ligase COG0212 Cluster_579628 V1244923 S ATP cone domain 0Y76S Cluster_455002 V1244924 PGSA map00564,map01100 I cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase COG0558 Cluster_145733 V1244925 CINA H competence damage-inducible protein COG1546 Cluster_299482 V1244926 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_39483 V1244927 HTPG map04141,map04151,map04612,map04621,map04626,map04914,map04915,map05200,map05215 O Molecular chaperone. Has ATPase activity (By similarity) COG0326 Cluster_106424 V1244928 AGCS E amino acid carrier protein COG1115 Cluster_384147 V1244929 S NA 0YSBG Cluster_23424 V1244930 S NA 11QZ9 Cluster_515236 V1244931 S NA 0YIA5 Cluster_884243 V1244933 S NA 0ZHH2 Cluster_599721 V1244934 ACPS map00770 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) COG0736 Cluster_200906 V1244935 AROG map00400,map01100,map01110,map01230 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) COG0722 Cluster_226644 V1244936 DUSB J Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_233721 V1244937 HSLO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) COG1281 Cluster_540208 V1244938 MAMA map00660,map01100 E Glutamate mutase subunit sigma COG2185 Cluster_110752 V1244939 MUTL2 map00660,map01100 S glutamate mutase, mutL 0XRSI Cluster_54754 V1244941 I Acyl-transferase COG1835 Cluster_592741 V1244942 Y1855 P asch domain protein COG4405 Cluster_91389 V1244943 S Membrane 11WHS Cluster_480414 V1244950 S Terminase small subunit 0ZPKN Cluster_546060 V1244952 YDII Q thioesterase Superfamily protein COG2050 Cluster_145734 V1244953 V Mate efflux family protein COG0534 Cluster_557779 V1244954 S Toxin-antitoxin system, antitoxin component, HicB family 12518 Cluster_199910 V1244955 SUCB map00010,map00020,map00620,map01100,map01110,map01120 C catalytic domain of components of various dehydrogenase complexes COG0508 Cluster_218486 V1244956 STERM_0028 map00010,map00020,map00620,map00650,map01100,map01110,map01120,map04066 C pyruvate dehydrogenase e1 component suBunit beta COG0022 Cluster_151228 V1244957 MURM map00550,map01100 V Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor (By similarity) COG2348 Cluster_296809 V1244958 SP_1245 S hydrolase COG0561 Cluster_345774 V1244959 S single-strand binding family protein 0XS6K Cluster_249079 V1244960 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_534520 V1244961 S NA 12CKW Cluster_86826 V1244962 YDDW M YngK protein COG1649 Cluster_579629 V1244964 RPSL map03010 J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) COG0048 Cluster_492189 V1244965 RPSG map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) COG0049 Cluster_416182 V1244966 map02010 E ABC, transporter COG0834 Cluster_348974 V1244967 YECC map02010 E abc transporter atp-binding protein COG1126 Cluster_112774 V1244969 SP_1213 S Uncharacterized protein conserved in bacteria (DUF2130) COG4487 Cluster_115574 V1244970 LKTB3 V ABC transporter, ATP-binding protein COG2274 Cluster_515237 V1244971 S NA 124N5 Cluster_380604 V1244978 VEX2 V abc transporter atp-binding protein COG1136 Cluster_326067 V1244979 PBR_0271 S NA 0Y0ES Cluster_148098 V1244980 PBR_0270 S Protein of unknown function DUF262 11FA3 Cluster_42956 V1244981 HUTU map00340,map01100 E Urocanate hydratase COG2987 Cluster_465182 V1244982 S Pfam:DUF567 COG4894 Cluster_456944 V1244983 S Nitroreductase family 11M4U Cluster_39305 V1244985 FUSA2 J Translation elongation factor COG0480 Cluster_367054 V1244986 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_338162 V1244987 T Response regulator receiver domain protein COG0745 Cluster_97892 V1244988 LON map04112 O ATP-dependent Lon protease COG4930 Cluster_193499 V1244989 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate (By similarity) COG0167 Cluster_665629 V1244990 L Inherit from COG: Transposase COG3039 Cluster_273739 V1244991 RLUA J pseudouridine synthase COG0564 Cluster_744842 V1244992 S RteC protein 10SVC Cluster_353760 V1244996 ATPB map00190,map00195,map01100 C it plays a direct role in the translocation of protons across the membrane (By similarity) COG0356 Cluster_734779 V1244997 ATPE map00190,map00195,map01100 C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) 0ZX31 Cluster_132660 V1244998 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_130359 V1244999 GPMI map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0696 Cluster_139008 V1245000 HTRA map03010 M peptidase S1 and S6, chymotrypsin Hap COG0265 Cluster_227786 V1245001 K LysR substrate binding domain 0ZWEJ Cluster_512541 V1245002 RSFS S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) COG0799 Cluster_324569 V1245003 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_396596 V1245004 map00550 M Penicillin-binding Protein dimerisation domain COG0772 Cluster_467274 V1245005 S NA 0ZCWM Cluster_43895 V1245008 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_629155 V1245010 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_439035 V1245011 S Pfam:DUF151 11EUJ Cluster_138253 V1245012 NUPG G nucleoside 0ZVFU Cluster_307890 V1245013 MURI map00230,map00240,map00471,map01100 M Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) COG0796 Cluster_809253 V1245014 AASI_0454 S NA 0XPYJ Cluster_237313 V1245016 MVAD map00900,map01100,map01110 I diphosphomevalonate decarboxylase COG3407 Cluster_288727 V1245018 YITL S S1 RNA binding domain protein COG2996 Cluster_238630 V1245020 S NA 11VIT Cluster_715063 V1245021 S NA 11VTP Cluster_724970 V1245023 RELE S cytotoxic translational repressor 0XYWD Cluster_734780 V1245024 S SpoVT_AbrB 121AX Cluster_306586 V1245025 S NA 11IAR Cluster_497178 V1245027 RPSG map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) COG0049 Cluster_208377 V1245028 BSH map00120,map00121,map01100 M Choloylglycine hydrolase COG3049 Cluster_715064 V1245030 HSDM V Type I restriction-modification system, M subunit COG0286 Cluster_71239 V1245031 TNAA map00350,map00380 E tryptophanase EC 4.1.99.1 COG3033 Cluster_333583 V1245033 PRFA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) COG0216 Cluster_119141 V1245034 CELD map02060 G Phosphotransferase system, EIIC COG1455 Cluster_458927 V1245035 S NA 0XVT8 Cluster_43896 V1245036 PRKC T serine threonine protein kinase COG0515 Cluster_449074 V1245037 ATPH map00190,map00195,map01100 C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) COG0712 Cluster_471552 V1245038 ATPF map00190,map00195,map01100 C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) COG0711 Cluster_469392 V1245039 map00770 S 4'-phosphopantetheinyl transferase 0XPB1 Cluster_73152 V1245040 YLOV S dak2 domain fusion protein ylov COG1461 Cluster_168546 V1245041 S NA 12DBK Cluster_109442 V1245043 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_265700 V1245044 RSGA G May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) COG1162 Cluster_378880 V1245045 RPE map00030,map00040,map00710,map01100,map01110,map01120,map01230 G ribulose-phosphate 3-epimerase COG0036 Cluster_669908 V1245046 THIN map00730,map01100 H thiamine COG1564 Cluster_801028 V1245048 L Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) COG0816 Cluster_224353 V1245049 PROTEASE map05120 O peptidase, U32 COG0826 Cluster_19997 V1245050 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_296810 V1245054 YDJY S iron-sulfur cluster binding 100DI Cluster_39484 V1245056 V Efflux ABC transporter, permease protein 0XPE8 Cluster_427142 V1245057 map00230 S NUDIX hydrolase 11K18 Cluster_128196 V1245060 S NA 0Z83I Cluster_106425 V1245061 RSEP map04112 M Membrane-associated zinc metalloprotease COG0750 Cluster_570085 V1245062 YJIM E 2-hydroxyglutaryl-CoA dehydratase COG1775 Cluster_163709 V1245063 RPOD map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_203989 V1245064 DNAG map03030 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 Cluster_515238 V1245065 BL02553 K Transcriptional regulator COG1959 Cluster_284513 V1245066 T metallophosphoesterase COG0639 Cluster_744844 V1245069 MURD map00471,map00550,map01100 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COG0771 Cluster_207251 V1245070 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_439036 V1245071 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_497179 V1245073 ABGT H Transporter COG2978 Cluster_465183 V1245074 ABGT H Transporter COG2978 Cluster_137488 V1245075 OCAR_5891 map00020,map00720,map01100,map01110,map01120,map05200,map05211 P iron permease COG0672 Cluster_614258 V1245076 S (Histidine triad) protein 11RAF Cluster_384148 V1245077 S Membrane 0ZXJB Cluster_637051 V1245078 PHNA map00440,map01120 P Alkylphosphonate utilization operon protein PhnA COG2824 Cluster_785326 V1245079 NAGA map00052,map00520,map01110 G GlcNAc 6-P deacetylase COG1820 Cluster_840161 V1245080 map02010 G (ABC) transporter COG3839 Cluster_63468 V1245081 SFUB map02010 P transporter (permease) COG1178 Cluster_637052 V1245082 S Membrane 11UEJ Cluster_447060 V1245083 RLMH S Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) COG1576 Cluster_431022 V1245084 COBO map00860,map01100 H Cob-I-yrinic acid a,c-diamide adenosyltransferase COG2109 Cluster_429040 V1245085 THIJ map05012 T DJ-1 family COG0693 Cluster_313772 V1245086 PROC map00330,map01100,map01110,map01230 E pyrroline-5-carboxylate reductase COG0345 Cluster_433021 V1245087 P Chromate transport protein COG2059 Cluster_434935 V1245088 CHRA P Chromate COG2059 Cluster_797094 V1245089 K Transcriptional regulator 121UZ Cluster_126106 V1245090 E, G, P Major Facilitator Superfamily COG0477 Cluster_142005 V1245091 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_65699 V1245092 EZRA D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) COG4477 Cluster_184701 V1245093 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_589371 V1245096 SCLAV_4550 L UPF0102 protein COG0792 Cluster_512542 V1245097 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_302248 V1245100 S GSCFA domain protein 0YSVQ Cluster_148099 V1245101 M glycosyl transferase group 1 0ZVDW Cluster_307891 V1245104 YAAA L UPF0246 protein COG3022 Cluster_452984 V1245105 WZB T protein tyrosine phosphatase COG0394 Cluster_140527 V1245106 GLYA map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01230 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) COG0112 Cluster_42219 V1245107 HPPA map00190 C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for COG3808 Cluster_245179 V1245108 GLYQ map00970 J glycyl-tRNA synthetase, alpha subunit COG0752 Cluster_403616 V1245109 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_554875 V1245110 K Rrf2 family 12BM4 Cluster_131136 V1245111 HOM E saf domain-containing protein COG4091 Cluster_303694 V1245112 S TonB family 11GC9 Cluster_237314 V1245113 PORQ S NA 11GCX Cluster_88125 V1245114 PQQL O Peptidase, M16 COG0612 Cluster_69617 V1245115 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_85920 V1245118 COMM O Mg chelatase subunit ChlI COG0606 Cluster_49970 V1245119 FTSI map00550,map01100 M penicillin-binding protein COG0768 Cluster_416183 V1245120 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_142783 V1245121 S conserved protein UCP033563 COG4198 Cluster_249080 V1245122 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_312275 V1245123 HIS2 L PHP domain protein COG1387 Cluster_269768 V1245124 YHBJ S Displays ATPase and GTPase activities (By similarity) COG1660 Cluster_596211 V1245125 NTPK map00190,map00680,map01100 C V-type sodium ATPase, K subunit COG0636 Cluster_45765 V1245126 NTPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_256464 V1245129 YUT E UreA transporter COG4413 Cluster_315357 V1245130 SURE map00230,map00240,map00760,map01100,map01110 F Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) COG0496 Cluster_540209 V1245132 map00400,map01100,map01110,map01230 S Plasmid pRiA4b ORF-3-like protein 0ZW43 Cluster_465184 V1245133 C Nitroreductase COG0778 Cluster_644921 V1245135 S NA 0ZTGB Cluster_38317 V1245136 CTPC map00190 P heavy metal translocating P-type ATPase COG2217 Cluster_324570 V1245137 VORB map00020,map00280,map00720,map01100,map01120 C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain COG1013 Cluster_154466 V1245138 PORG map00020,map00720,map01100,map01120 C oxidoreductase COG1014 Cluster_296811 V1245139 TRMD map00900,map01100,map01110 J Specifically methylates guanosine-37 in various tRNAs (By similarity) COG0336 Cluster_220834 V1245141 K, L, T serine threonine protein kinase COG0515 Cluster_176967 V1245142 PUCG map00250,map00260,map00630,map00680,map01100,map01110,map01120,map04146 E Aminotransferase COG0075 Cluster_243904 V1245143 S NA 0XWFB Cluster_97893 V1245144 map03440 K Transcriptional regulator COG2865 Cluster_144233 V1245145 S NA 0ZS65 Cluster_294057 V1245146 S NA 1249W Cluster_567001 V1245147 S HIRAN domain 0XVUM Cluster_480415 V1245148 S isoprenylcysteine carboxyl methyltransferase family protein 0ZWP8 Cluster_467275 V1245150 Q isochorismatase COG1335 Cluster_108197 V1245154 K, L domain protein COG0553 Cluster_669909 V1245155 S VRR-NUC domain protein 122HE Cluster_592743 V1245156 CTSR K transcriptional regulator, ctsr COG4463 Cluster_375325 V1245157 S NA 0YEUF Cluster_758591 V1245158 ACPP I Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) COG0236 Cluster_139009 V1245159 FABF map00061,map00780,map01100 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) COG0304 Cluster_606930 V1245160 PURN map00230,map00670,map01100,map01110 F phosphoribosylglycinamide formyltransferase COG0299 Cluster_94173 V1245161 P transporter COG0471 Cluster_425224 V1245162 map00350,map00362,map00627,map00642,map00903,map01120 S -acetyltransferase 11TPW Cluster_197923 V1245163 NADA map00760,map01100 H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) COG0379 Cluster_633007 V1245164 NADC map00760,map01100 H nicotinate-nucleotide pyrophosphorylase COG0157 Cluster_715065 V1245165 LSPA map03060 M, U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) COG0597 Cluster_260383 V1245166 RLUD J Pseudouridine synthase COG0564 Cluster_494667 V1245167 NRDR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) COG1327 Cluster_425225 V1245168 DNAB L replication initiation and membrane attachment COG3611 Cluster_330514 V1245169 K transcriptional regulator MERR family 1231N Cluster_104611 V1245170 S c4-dicarboxylate anaerobic carrier COG1288 Cluster_549096 V1245171 T phosphohistidine phosphatase, SixA COG2062 Cluster_380605 V1245172 T response regulator COG0745 Cluster_272407 V1245173 T Histidine kinase COG0642 Cluster_217353 V1245174 N Cell surface protein 0XQ7Y Cluster_748190 V1245175 K Sigma factor 0YGB2 Cluster_74822 V1245177 S NA 0Y12I Cluster_350596 V1245178 V abc transporter atp-binding protein COG1131 Cluster_194435 V1245179 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_385925 V1245180 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_515239 V1245181 DTD J Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) COG1490 Cluster_449075 V1245182 S Hdig domain protein COG1418 Cluster_228951 V1245183 SCRR K Sucrose operon repressor COG1609 Cluster_721621 V1245186 S Copper-sensing transcriptional repressor CsoR COG1937 Cluster_21937 V1245187 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_85545 V1245189 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_543110 V1245190 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_80976 V1245191 HUTH map00340,map01100 E Histidine ammonia-lyase COG2986 Cluster_265701 V1245192 FTCD map00340,map00670,map01100 E Glutamate formiminotransferase COG3643 Cluster_237315 V1245193 OPPC map02010 P abc transporter, permease COG1173 Cluster_243905 V1245194 OPPB map02010 P ABC transporter (Permease COG0601 Cluster_391183 V1245195 K Transcriptional regulator, TetR family 0ZXSC Cluster_138254 V1245196 PBUX F permease COG2233 Cluster_451041 V1245197 SP_2191 S isoprenylcysteine carboxyl methyltransferase family protein COG1755 Cluster_237316 V1245198 S NA 0XPAY Cluster_281733 V1245199 FUMA map00020,map00720,map01100,map01110,map01120 C Hydrolyase, Fe-S type, tartrate fumarate subfamily, alpha subunit COG1951 Cluster_151229 V1245200 HEMN map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_215021 V1245202 map00230 F, P ppx gppa phosphatase COG0248 Cluster_485049 V1245203 L Inherit from COG: transposase COG3464 Cluster_471553 V1245204 L Inherit from COG: transposase COG3464 Cluster_97894 V1245206 PEPA map00480,map01100 E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) COG0260 Cluster_781224 V1245208 COBQ S Glutamine amidotransferase COG3442 Cluster_122843 V1245209 MURE map00300,map00550 M mur ligase COG0769 Cluster_329112 V1245210 S DNA metabolism protein 11MJI Cluster_111439 V1245213 S fad dependent oxidoreductase COG2509 Cluster_255231 V1245214 RLUD J Pseudouridine synthase COG0564 Cluster_851878 V1245215 LSPA map03060 M, U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) COG0597 Cluster_179515 V1245216 FTSW map04112 D cell division protein FtsW COG0772 Cluster_159553 V1245218 CAPA M Capsule synthesis protein COG2843 Cluster_233722 V1245220 GYAR map00260,map00630,map00680,map01100,map01120,map01230 C D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding COG1052 Cluster_290006 V1245222 S esterase COG2819 Cluster_330515 V1245223 S esterase COG4947 Cluster_427143 V1245224 SP_0885 S domain protein 0XRFP Cluster_573285 V1245225 RBFA J Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) COG0858 Cluster_242553 V1245226 ARCC map00230,map00330,map00910,map01120 E carbamate kinase COG0549 Cluster_190757 V1245227 COBD map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01230 E decarboxylase COG0079 Cluster_23975 V1245228 L Inherit from COG: DNA Methylase COG0827 Cluster_339582 V1245229 WECG M Glycosyl transferase, wecb taga cpsf family COG1922 Cluster_101154 V1245232 TRKH P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) COG0168 Cluster_724971 V1245234 RPSO map03010 J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) COG0184 Cluster_52830 V1245235 map03420,map03430 L helicase COG0210 Cluster_777468 V1245237 S NA 1260K Cluster_455003 V1245238 S DNA-binding helix-turn-helix protein 11HJM Cluster_227787 V1245240 PYRB map00240,map00250,map01100 F aspartate transcarbamylase COG0540 Cluster_526146 V1245241 PYRI map00240,map00250,map01100 F Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) COG1781 Cluster_452985 V1245242 PYRF map00240,map00983,map01100 F orotidine 5''-phosphate decarboxylase COG0284 Cluster_298202 V1245243 THID map00730,map00750,map01100 H phosphomethylpyrimidine kinase COG0351 Cluster_463101 V1245244 THIW S thiw protein COG4732 Cluster_73522 V1245245 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_614259 V1245246 RBFA J Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) COG0858 Cluster_633008 V1245248 PLSX map00561,map00564,map01100 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) COG0416 Cluster_154467 V1245249 C domain protein 0ZB0Z Cluster_183820 V1245250 PEPP map00310,map00780,map01100 E peptidase M24 COG0006 Cluster_330516 V1245252 NITSA_0073 S transposase 11TFP Cluster_382380 V1245253 L Inherit from COG: Helicase COG1112 Cluster_76432 V1245256 BT_2352 L Transposase COG3436 Cluster_377092 V1245257 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_549097 V1245258 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_269769 V1245259 RFBD map00521,map00523,map01100,map01110 M Dtdp-4-dehydrorhamnose reductase COG1091 Cluster_403617 V1245260 S NA 11MP2 Cluster_362031 V1245261 S Lysine exporter protein (Lyse ygga) 11GJN Cluster_614260 V1245262 ASP S Alkaline-shock protein COG1302 Cluster_44290 V1245264 CAS3 L CRISPR-associated helicase, cas3 COG1203 Cluster_54539 V1245265 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_405432 V1245267 NRDG O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) COG0602 Cluster_475813 V1245268 SP_0204 S acetyltransferase, (GNAT) family COG3981 Cluster_482732 V1245270 MOAB map00790,map01100,map04122 H Molybdenum cofactor synthesis domain protein COG0521 Cluster_451042 V1245271 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_403618 V1245272 S outer membrane lipoprotein carrier protein 11YKN Cluster_344160 V1245275 RPRY T response regulator COG0745 Cluster_298203 V1245276 S smc domain-containing protein 0XTF4 Cluster_215022 V1245277 L metallophosphoesterase COG0420 Cluster_625464 V1245278 S prophage pi2 protein 38 11U3I Cluster_582874 V1245279 S Prophage pi2 protein 37 11UE0 Cluster_44489 V1245280 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_167699 V1245281 map00561,map01100 M Glycosyl transferase (Group 1 COG0438 Cluster_394821 V1245282 YJBF S SNARE-like domain protein COG0398 Cluster_813250 V1245283 CPOA M Glycosyl transferase COG0438 Cluster_147304 V1245285 ARCA map00330,map01100,map01110 E Arginine dihydrolase COG2235 Cluster_223168 V1245286 YEIH S Membrane COG2855 Cluster_859673 V1245287 YHEH V ABC transporter COG1132 Cluster_475814 V1245288 YBEY map00240,map00983,map01100 F Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) COG0319 Cluster_256465 V1245289 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_67897 V1245291 ALSS map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E acetolactate synthase COG0028 Cluster_105815 V1245293 YGCG S of methanol dehydrogenase type COG1512 Cluster_832370 V1245294 S NA 11NI8 Cluster_39306 V1245295 MCRB V ATPase associated with various cellular activities aaa_5 COG1401 Cluster_134288 V1245296 S radical SAM domain protein COG0641 Cluster_25601 V1245297 S NA 101UU Cluster_180344 V1245298 PROB map00330,map01100,map01230 E Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) COG0263 Cluster_425226 V1245299 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG0194 Cluster_423422 V1245300 NADD map00230,map00760,map01100,map05340 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) COG1057 Cluster_400056 V1245301 RIBE map00740,map01100 H riboflavin synthase, subunit alpha COG0307 Cluster_178646 V1245302 RIBD map00740,map01100 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) COG1985 Cluster_330517 V1245304 YBIW map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_128911 V1245305 PTCC map02060 G pts system COG1455 Cluster_363600 V1245306 G Domain-Containing protein 11Q0T Cluster_95212 V1245307 RUMA map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_129623 V1245308 YIEG S Xanthine uracil vitamin C permease COG2252 Cluster_728268 V1245309 YLXR K Nucleic-acid-binding protein implicated in transcription termination COG2740 Cluster_149597 V1245310 map03420,map03430 L DNA helicase 0XQN2 Cluster_26260 V1245311 S NA 0YZ82 Cluster_385926 V1245312 G Acyl-transferase COG3594 Cluster_396597 V1245313 S NA 0Y9SS Cluster_339583 V1245314 T response regulator (Receiver 11EZS Cluster_142006 V1245315 SSTT E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) COG3633 Cluster_201897 V1245316 YEIH S Membrane COG2855 Cluster_427144 V1245317 AHPC O C-terminal domain of 1-Cys peroxiredoxin COG0450 Cluster_85546 V1245318 AHPF O Alkyl hydroperoxide reductase COG3634 Cluster_109443 V1245319 OPPD map02010 E, P ABC transporter COG0444 Cluster_211625 V1245320 DNAD L DNA replication protein DnaD COG3935 Cluster_683298 V1245321 DINF V Mate efflux family protein COG0534 Cluster_119142 V1245322 map00521,map00562,map01100,map01110 I inositoL-3-phosphate synthase COG1260 Cluster_26894 V1245323 V abc transporter permease protein COG0577 Cluster_143480 V1245324 S UPF0597 protein COG3681 Cluster_534521 V1245325 BDI_0123 S NA 11NUB Cluster_45003 V1245326 ALIB2 map02010 E Oligopeptide-binding protein COG4166 Cluster_247761 V1245327 NANH map00300,map00520,map01100,map01110,map01120,map01230 E, M N-acetylneuraminate lyase COG0329 Cluster_32710 V1245328 O cysteine protease COG4870 Cluster_48543 V1245329 SCRA map00500,map02060 G pts system COG2190 Cluster_193500 V1245331 YUFP S ABC transporter (Permease COG4603 Cluster_29447 V1245332 BGAA map00052,map00511,map00600,map01100 G glycoside hydrolase family 2 COG3525 Cluster_478011 V1245333 S NA 11XBE Cluster_416185 V1245334 COMF S Competence protein COG1040 Cluster_126107 V1245335 S Phage portal protein, SPP1 Gp6-like 11J8D Cluster_226645 V1245336 map00520,map01100,map01110 M Acylneuraminate cytidylyltransferase COG1778 Cluster_33878 V1245337 YJCD map03420,map03430 L helicase COG0210 Cluster_419766 V1245339 M Export protein COG1596 Cluster_396598 V1245340 M Bacterial sugar transferase COG2148 Cluster_264371 V1245341 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_256466 V1245342 RIBF map00740,map01100 H riboflavin biosynthesis protein ribF COG0196 Cluster_445008 V1245343 RPLE map03010 J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COG0094 Cluster_449076 V1245344 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_449077 V1245345 S NA 0YB54 Cluster_412532 V1245346 PLSY map00561,map00564,map01100 S Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) COG0344 Cluster_126108 V1245347 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_97363 V1245348 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_307892 V1245349 SLGD_00064 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_102269 V1245350 COMEC S DNA internalization-related competence protein ComEC Rec2 COG2333 Cluster_633009 V1245351 COMEA L Competence protein COG1555 Cluster_142007 V1245352 DCTP C symporter COG1301 Cluster_618016 V1245353 S beta-propeller domains of methanol dehydrogenase type COG1512 Cluster_187335 V1245354 YNII S Zinc finger domain 0XNNM Cluster_599722 V1245358 RBFA J Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) COG0858 Cluster_257747 V1245359 COMEA L Competence protein COG1555 Cluster_436996 V1245361 S NA 120PT Cluster_537411 V1245362 S NA 121S9 Cluster_306587 V1245363 YHCC S Radical SAM Protein COG1242 Cluster_34203 V1245364 PPC map00620,map00680,map00710,map00720,map01100,map01120 C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) COG2352 Cluster_56509 V1245365 META map00270,map00920,map01100,map01110,map01230 E Homoserine O-transsuccinylase COG1897 Cluster_507365 V1245366 S NA 100RW Cluster_39307 V1245367 S NA 11QZ9 Cluster_139792 V1245371 M Inherit from COG: YD repeat protein COG3209 Cluster_137489 V1245373 SERP0565 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_108810 V1245374 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_132661 V1245375 YIEG S Xanthine uracil vitamin C permease COG2252 Cluster_509969 V1245376 METG J emap domain COG0073 Cluster_705442 V1245377 S excisionase 11SUH Cluster_352100 V1245378 map04112 L DNA methylase N-4 N-6 COG0863 Cluster_277731 V1245381 ECORIM L Modification methylase EcoRI 0XPU0 Cluster_295465 V1245383 RSMI G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 Cluster_250332 V1245384 S (LipO)protein 11K11 Cluster_563820 V1245385 S GDSL-like protein 11TT5 Cluster_509970 V1245386 S NA 121KJ Cluster_147305 V1245387 ALGI M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_353761 V1245388 S NA 11NFI Cluster_38139 V1245389 UVRD map03420,map03430 L ATP-dependent DNA helicase pcra COG0210 Cluster_455004 V1245391 PGN_0055 S NA 11YX6 Cluster_148100 V1245392 G alpha amylase, catalytic COG0366 Cluster_485050 V1245393 map02010 P ABC transporter, permease COG3833 Cluster_648999 V1245394 YAAQ S protein from nitrogen regulatory protein P-II COG3870 Cluster_400057 V1245395 TMK map00240,map01100 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) COG0125 Cluster_205069 V1245397 S Acyltransferase family 0YSHG Cluster_534522 V1245398 T FHA domain 0XUTQ Cluster_523236 V1245399 RECX S Modulates RecA activity (By similarity) COG2137 Cluster_728269 V1245400 YAZA L domain protein COG2827 Cluster_407099 V1245402 CBIE map00860,map01100 H Precorrin-6Y C5,15-methyltransferase (Decarboxylating), CbiE subunit COG2241 Cluster_191676 V1245403 CBID map00860,map01100,map02010 H May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) COG1903 Cluster_88126 V1245404 NHAC C Na H antiporter COG1757 Cluster_177806 V1245405 map00300,map01100,map01110,map01120,map01230 E decarboxylase COG0019 Cluster_175354 V1245406 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_455005 V1245407 PAIA map00350,map00362,map00627,map00642,map00903,map01120 K Protease synthase and sporulation negative regulatory protein pai 1 COG0454 Cluster_637053 V1245408 map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020 C fumarate reductase succinate dehydrogenase flavoprotein domain protein COG1053 Cluster_108198 V1245409 FTSI map00550 M penicillin-binding protein COG0768 Cluster_447061 V1245410 K Transcriptional regulator COG1396 Cluster_175355 V1245412 ACD map00071,map00280,map00281,map00362,map00410,map00640,map00650,map01100,map01110,map01120,map03320 I Acyl-CoA dehydrogenase, C-terminal domain COG1960 Cluster_283140 V1245414 S NA 0ZUV1 Cluster_155302 V1245415 NDVA2 V ABC transporter, ATP-binding protein COG1132 Cluster_190758 V1245416 V ABC transporter COG1132 Cluster_299483 V1245417 BDP_1102 V ABC transporter COG1136 Cluster_96303 V1245418 LDTA S ErfK YbiS YcfS YnhG COG1376 Cluster_210498 V1245419 METX map00270,map00920,map01100 E Homoserine O-trans-acetylase COG2021 Cluster_54540 V1245420 S Membrane 0Y3RG Cluster_509971 V1245421 S NA 11JFU Cluster_350597 V1245422 BDP_1102 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_181167 V1245423 V ABC transporter, permease COG0577 Cluster_358788 V1245424 map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_378881 V1245425 PSTA map02010 P phosphate abc transporter COG0581 Cluster_190759 V1245426 S NA 0YXMU Cluster_687724 V1245427 GCVR T UPF0237 protein COG3830 Cluster_372000 V1245428 SP_0239 S UPF0210 protein COG2848 Cluster_75790 V1245429 GGT map00430,map00460,map00480,map00590,map01100 E gamma-glutamyltransferase COG0405 Cluster_133493 V1245430 S NA 11YT1 Cluster_606931 V1245431 GLNR K Transcriptional regulator COG0789 Cluster_118411 V1245432 GLNA map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG0174 Cluster_828619 V1245433 S DNA- binding protein COG4699 Cluster_277732 V1245434 S NA 11JZU Cluster_234916 V1245435 G Trap dicarboxylate transporter, dctp subunit COG1638 Cluster_377093 V1245437 S NA 12BEE Cluster_705443 V1245441 YKTA S UPF0223 protein COG4476 Cluster_313773 V1245442 SUHB map00521,map00562,map01100,map01110,map04070 G inositol monophosphatase COG0483 Cluster_285956 V1245443 SUN map00340,map00350,map00624,map01120 J NOL1 NOP2 sun family protein COG3270 Cluster_300868 V1245444 KDSA map00540,map01100 M Phospho-2-dehydro-3-deoxyoctonate aldolase COG2877 Cluster_589373 V1245446 T Universal stress COG0589 Cluster_31744 V1245447 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_644922 V1245448 BMUR_1331 V Hnh endonuclease 0XZKB Cluster_257748 V1245450 RLUD J Pseudouridine synthase COG0564 Cluster_504782 V1245451 LSPA map03060 M, U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) COG0597 Cluster_695991 V1245452 O Inherit from COG: glutaredoxin-related protein COG4545 Cluster_234917 V1245453 E, G of the drug metabolite transporter COG0697 Cluster_306588 V1245454 L Bacterial dnaA protein COG1484 Cluster_543112 V1245457 S Helix-turn-helix 11HER Cluster_425227 V1245458 S Hydrolase COG4814 Cluster_269770 V1245459 PFLA O Pyruvate formate-lyase COG1180 Cluster_241180 V1245460 PPAC map00190 C Manganese-dependent inorganic pyrophosphatase COG1227 Cluster_32081 V1245461 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_355427 V1245462 S Abi-like protein 0ZYGF Cluster_687725 V1245463 C Alcohol dehydrogenase zinc-binding domain protein COG1063 Cluster_434936 V1245465 LEMA S LemA family COG1704 Cluster_292675 V1245466 S GDSL-like protein 11TT5 Cluster_223169 V1245467 LPLA map00785,map01100 H Lipoate-protein, ligase COG0095 Cluster_95714 V1245470 L Domain protein COG0507 Cluster_579630 V1245472 S Pfam:DUF2825 1286S Cluster_280395 V1245473 O DnaJ domain protein COG1076 Cluster_515240 V1245474 V type I restriction enzyme 11IAT Cluster_271079 V1245475 LACX map00010,map01110,map01120 G aldose 1-epimerase COG2017 Cluster_567002 V1245476 RPSH map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) COG0096 Cluster_445009 V1245477 RPLE map03010 J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COG0094 Cluster_669910 V1245478 RPLX map03010 J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) COG0198 Cluster_375326 V1245481 S Chromosome segregation ATPase 11HKQ Cluster_699278 V1245485 S NA 11M4I Cluster_55506 V1245486 PULA G Glycogen debranching enzyme COG1523 Cluster_306589 V1245490 CODY K DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) COG4465 Cluster_579631 V1245491 GCVH map00630,map01110 E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) COG0509 Cluster_131905 V1245492 APEB E M18 family aminopeptidase COG1362 Cluster_65399 V1245493 ARGS map00970 J Arginyl-tRNA synthetase COG0018 Cluster_48544 V1245494 E Family 5 COG0747 Cluster_107642 V1245496 BL00983 S Phage Portal Protein 11QNG Cluster_114227 V1245498 UUP S Abc transporter, ATP-binding protein COG0488 Cluster_579632 V1245499 S NA 12AV7 Cluster_372001 V1245500 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_352101 V1245501 PUUD J Glutamine amidotransferase COG2071 Cluster_551979 V1245502 YPJC S YitT family COG1284 Cluster_177807 V1245503 HLY map04621 S Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation 0XQPX Cluster_687726 V1245504 YERC S protein, YerC YecD COG4496 Cluster_68224 V1245505 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_160399 V1245507 SP_1634 S Protein of unknown function (DUF2974) 0XSVF Cluster_820847 V1245508 MIDI_00056 L Transposase 0YEAS Cluster_59593 V1245509 YFIC map02010 V ABC transporter COG1132 Cluster_570086 V1245510 BDHA map00051,map00363,map00591,map00625,map00650,map01100,map01120 C alcohol dehydrogenase COG1979 Cluster_637054 V1245511 S NA 11SH1 Cluster_93751 V1245512 TRAA map03440 L mobA MobL family protein COG0507 Cluster_414413 V1245514 S NA 127XX Cluster_358789 V1245515 PEPE map00480,map01100 E peptidase S51, dipeptidase E COG3340 Cluster_285957 V1245516 S domain protein 0XNZW Cluster_557780 V1245517 T response regulator COG0745 Cluster_363601 V1245518 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_614261 V1245520 S NA 12490 Cluster_785328 V1245521 S NA 1242R Cluster_69618 V1245523 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_162064 V1245524 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01230 G phosphohexose isomerase COG0166 Cluster_121405 V1245526 RNFC C Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) COG4656 Cluster_48545 V1245527 FRUA map00051,map01100,map02060 G PTS System COG1762 Cluster_341047 V1245528 T Two component transcriptional regulator, winged helix family COG0745 Cluster_264372 V1245529 map02020 T Histidine kinase COG0642 Cluster_487340 V1245531 J Elongation factor Tu GTP binding domain COG0050 Cluster_142784 V1245532 V Mate efflux family protein COG0534 Cluster_781225 V1245534 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_345775 V1245535 CCDA O cytochrome c-type biogenesis protein COG0785 Cluster_252774 V1245541 LDTA S ErfK YbiS YcfS YnhG COG1376 Cluster_452986 V1245542 V abc transporter permease protein COG0577 Cluster_421560 V1245543 L Replication Protein 0YRQ2 Cluster_596213 V1245546 S mobilization protein 11J0G Cluster_206154 V1245547 PHOR T Histidine kinase 0XNMH Cluster_35711 V1245549 L N-6 DNA Methylase 0XTBT Cluster_657207 V1245550 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_241181 V1245551 HPRK T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) COG1493 Cluster_358790 V1245552 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_489689 V1245556 S Gp157 family 11ZXY Cluster_375327 V1245557 STERM_0814 S Erf family 11TP8 Cluster_228952 V1245558 S NA 0ZU63 Cluster_254021 V1245559 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate (By similarity) COG0167 Cluster_702346 V1245560 S domain protein 12A92 Cluster_102270 V1245562 T Histidine kinase 0XNMH Cluster_576518 V1245563 AROK map00400,map01100,map01110,map01230 E Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) COG0703 Cluster_285958 V1245564 PHEA map00400,map01100,map01110,map01230 E Prephenate dehydratase COG0077 Cluster_705444 V1245565 S mobilization protein 11J0G Cluster_458928 V1245566 FUR K regulator Fur family COG0735 Cluster_36400 V1245568 PBP2B map00550,map01100 M penicillin-binding protein COG0768 Cluster_91873 V1245570 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) COG0442 Cluster_112775 V1245571 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_614262 V1245572 YCEE S Hydrolase 11NRG Cluster_755079 V1245573 CAPA M Capsule synthesis protein COG2843 Cluster_417986 V1245574 OCAR_6752 H DNA integration recombination invertion protein COG1636 Cluster_321423 V1245575 LGT M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 Cluster_499846 V1245576 RIBH map00740,map01100 H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) COG0054 Cluster_42220 V1245577 FLGJ map00511 N, U flagellar rod assembly protein muramidase flgj COG1705 Cluster_70547 V1245579 S DNA primase COG3378 Cluster_451043 V1245581 C Rubrerythrin COG1592 Cluster_192616 V1245582 PRFA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) COG0216 Cluster_139793 V1245583 MSME map02010 G extracellular solute-binding protein family 1 COG1653 Cluster_373618 V1245585 BDP_1102 V ABC transporter, ATP-binding protein COG1136 Cluster_112055 V1245586 GLTA map00250,map00910,map01100,map01110,map01120,map01230 E glutamate synthase COG0543 Cluster_427146 V1245587 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_232461 V1245588 V Type II restriction 0YBMI Cluster_241182 V1245589 AMPC V Beta-lactamase COG1680 Cluster_573288 V1245590 S TIM-barrel fold 11FGY Cluster_394822 V1245591 NNRE G Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity) COG0062 Cluster_117003 V1245592 V Mate efflux family protein COG0534 Cluster_417987 V1245593 RDGB map00230,map00240,map01100 F Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) COG0127 Cluster_335083 V1245594 RPH map00230,map00240,map01100 J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) COG0689 Cluster_419767 V1245595 LEPB map03060 U Signal peptidase i COG0681 Cluster_485051 V1245598 RUVC map03440 L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) COG0817 Cluster_417988 V1245599 RUVA map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) COG0632 Cluster_89520 V1245600 S NA 11QVU Cluster_876045 V1245601 S sigma-70, region 4 11JJM Cluster_117004 V1245602 YAAO map00310,map00330,map00960,map01100,map01110 E decarboxylase COG1982 Cluster_403619 V1245603 TMK map00240,map01100 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) COG0125 Cluster_487341 V1245604 L Resolvase, N-terminal domain protein COG1961 Cluster_168547 V1245605 V abc transporter permease protein 0ZW5X Cluster_445010 V1245606 LEMA S LemA family COG1704 Cluster_70895 V1245608 PPDK map00620,map00710,map01100,map01120 G pyruvate phosphate dikinase COG0574 Cluster_515241 V1245609 RIMP S Required for maturation of 30S ribosomal subunits (By similarity) COG0779 Cluster_38995 V1245610 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_360454 V1245611 CP_0141 S metallophosphoesterase COG1768 Cluster_451044 V1245612 map00230 F Adenylate cyclase COG1437 Cluster_641041 V1245613 YPSA S UPF0398 protein COG4474 Cluster_614263 V1245614 GPSB D Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) COG3599 Cluster_46926 V1245616 BCGIA V Type II restriction modification enzyme methyltransferase COG0286 Cluster_909136 V1245617 HSDS V Restriction modification system DNA specificity COG0732 Cluster_189901 V1245618 MDLA V ABC transporter, ATP-binding protein COG1132 Cluster_284514 V1245619 K AraC Family Transcriptional Regulator COG2207 Cluster_269771 V1245620 CMK map00240,map00410,map00770,map01100,map01110 F Cytidine monophosphate kinase COG0283 Cluster_427147 V1245621 PLSC map00561,map00564,map01100 I Acyl-transferase COG0204 Cluster_111440 V1245622 TIG O Trigger factor COG0544 Cluster_344161 V1245624 RNC map03008,map05205 K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) COG0571 Cluster_283141 V1245625 B, K radical SAM domain protein COG1243 Cluster_272408 V1245626 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_85921 V1245628 S NA 0YD1F Cluster_193501 V1245629 L Phage integrase family COG4974 Cluster_494670 V1245630 S acetyltransferase, (GNAT) family 11DS9 Cluster_335084 V1245631 LGAS_0583 S Replication Protein 0YVZX Cluster_606932 V1245632 YHCF K TRANSCRIPTIONAl REGULATOR GntR family COG1725 Cluster_358791 V1245633 YHCG V abc transporter atp-binding protein COG1131 Cluster_318457 V1245634 S NA 0Z9TE Cluster_427148 V1245636 S pkd domain 0ZXSR Cluster_251552 V1245638 YICL E, G Transporter COG0697 Cluster_141280 V1245640 BL03321 G Major Facilitator COG0477 Cluster_534523 V1245641 K Transcriptional regulator, ARSR family 0XUWM Cluster_259077 V1245642 MAZG map00230,map00240,map01100 F mazG family COG1694 Cluster_272409 V1245643 RPOS map05111 K RNA polymerase COG0568 Cluster_482733 V1245644 S NA 0YEME Cluster_101155 V1245645 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_70244 V1245646 PHOR map02020 T Histidine kinase 0XNMH Cluster_755080 V1245647 DLTC map00473,map05150 H Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) COG0236 Cluster_239902 V1245648 SRTB M (sortase) family COG3764 Cluster_46145 V1245649 M YD repeat protein COG3209 Cluster_137490 V1245650 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_196164 V1245651 YUFN S basic membrane COG1744 Cluster_218487 V1245652 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_339584 V1245654 YBHL S Membrane COG0670 Cluster_318458 V1245656 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_789344 V1245658 S YD repeat protein 0Z0FY Cluster_73153 V1245659 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_586068 V1245662 L Resolvase COG1961 Cluster_773737 V1245663 S NA 0ZMX8 Cluster_184702 V1245664 S X-Pro dipeptidyl-peptidase (S15 family) 0ZJEE Cluster_515242 V1245665 MUTT L Nudix family COG0494 Cluster_687727 V1245666 S Domain of unknown function (DUF1827) 0XV2U Cluster_312276 V1245667 STRA J Aminoglycoside COG3231 Cluster_307893 V1245668 RECX S Modulates RecA activity (By similarity) COG2137 Cluster_241183 V1245669 GPPA map00230 F, P ppx gppa phosphatase COG0248 Cluster_463103 V1245670 FOLA map00670,map00790,map01100 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) COG0262 Cluster_384149 V1245671 map00670,map01100 E Methenyltetrahydrofolate cyclohydrolase COG3404 Cluster_44842 V1245674 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_280396 V1245676 ENDA S DNA-entry nuclease 12175 Cluster_218488 V1245677 FLUTA_0256 L Transposase COG3464 Cluster_618018 V1245678 CELAL_0017 S NA 11TT6 Cluster_582875 V1245679 S Tetratricopeptide repeat protein 0ZCCT Cluster_360455 V1245683 O Cytochrome c biogenesis protein COG0785 Cluster_392995 V1245684 S Thioredoxin 12AE3 Cluster_239903 V1245690 PDXB map00260,map00620,map00630,map01100,map01120 E, H D-isomer specific 2-hydroxyacid dehydrogenase COG0111 Cluster_497181 V1245691 CAS3 L CRISPR-Associated Helicase Cas3 COG1203 Cluster_460980 V1245692 S NA 0Y8QF Cluster_392996 V1245693 map02010 S Permease, YjgP YjgQ family COG0795 Cluster_855650 V1245694 YAFQ S addiction module toxin, RelE StbE family COG3041 Cluster_171986 V1245695 NEUC map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_302249 V1245696 S ABC, transporter 11NKI Cluster_353762 V1245697 YHCG V abc transporter atp-binding protein COG1131 Cluster_321424 V1245698 S caax amino 11X7J Cluster_441016 V1245699 K RNA Polymerase COG1595 Cluster_669912 V1245700 S NA 0YJPQ Cluster_382381 V1245701 YRRM map00340,map00350,map00360,map00624,map00940,map00941,map00945,map01100,map01110,map01120 S O-methyltransferase COG4122 Cluster_247762 V1245702 NIKC map02010 P abc transporter, permease COG1173 Cluster_41222 V1245704 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_649000 V1245705 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_287363 V1245706 SRTA M (sortase) family COG3764 Cluster_154468 V1245707 COABC map00770,map01100 H Phosphopantothenoylcysteine decarboxylase COG0452 Cluster_276422 V1245708 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_389454 V1245709 map02020 K Transcriptional Regulator AraC Family COG4753 Cluster_336614 V1245710 RSME S Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) COG1385 Cluster_59594 V1245711 S copper amine 121X1 Cluster_93752 V1245712 HTRA map02020,map03010 M serine protease COG0265 Cluster_71519 V1245713 YCEG F aminodeoxychorismate lyase COG1559 Cluster_80588 V1245714 C radical SAM domain protein COG1032 Cluster_482734 V1245715 RIMM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) COG0806 Cluster_770051 V1245716 YLQC S UPF0109 protein COG1837 Cluster_687728 V1245717 RPSP map03010 J 30s ribosomal protein S16 COG0228 Cluster_358792 V1245718 ENGB S Necessary for normal cell division and for the maintenance of normal septation (By similarity) COG0218 Cluster_242554 V1245721 M N-acetylmuramoyl-L-alanine amidase COG0860 Cluster_243906 V1245726 MENA map00130,map01100,map01110 H 1,4-dihydroxy-2-naphthoate octaprenyltransferase COG1575 Cluster_169476 V1245728 ATPB map00190,map00195,map01100 C it plays a direct role in the translocation of protons across the membrane (By similarity) COG0356 Cluster_554877 V1245731 OCAR_4302 S Protein of unknown function (DUF1232) COG3339 Cluster_520478 V1245732 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_259078 V1245733 YEGQ map05120 O Peptidase U32 COG0826 Cluster_135891 V1245734 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_368663 V1245735 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_683299 V1245736 GATC map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0721 Cluster_332073 V1245737 NAGB map00520,map01100,map01110 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COG0363 Cluster_257749 V1245738 S relaxase mobilization nuclease domain protein 0XNXG Cluster_287364 V1245739 LGT M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 Cluster_131137 V1245740 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG2812 Cluster_695992 V1245741 YAAK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) COG0718 Cluster_42779 V1245742 S NA 0ZTYV Cluster_465185 V1245744 YNHI map00900,map01110 S heptaprenyl diphosphate synthase component I COG4769 Cluster_350598 V1245745 RADC L DNA repair protein (RadC COG2003 Cluster_431023 V1245746 S RelA SpoT domain protein 0XPFE Cluster_348975 V1245747 V abc transporter atp-binding protein COG1131 Cluster_43138 V1245749 O cysteine protease COG4870 Cluster_66289 V1245750 M Inherit from COG: YD repeat protein COG3209 Cluster_233723 V1245751 TRXB map00240,map00450 O thioredoxin reductase COG0492 Cluster_358793 V1245753 K Peptidase S24-like 0XUC3 Cluster_200907 V1245754 INT L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) COG0582 Cluster_152059 V1245755 OCAR_6158 L Terminase, large subunit COG4626 Cluster_46529 V1245756 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (alpha subunit) COG0587 Cluster_309312 V1245757 COAX map00770,map01100 K Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) COG1521 Cluster_447062 V1245758 BIOY map02010 S bioY protein COG1268 Cluster_296812 V1245759 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_355428 V1245760 FNR T transcriptional regulator, crp fnr family COG0664 Cluster_549098 V1245761 F cytidine deoxycytidylate deaminase COG0295 Cluster_91390 V1245762 ASPC map00250,map00290,map01100,map01110,map01210,map01230 E Aminotransferase COG0436 Cluster_805227 V1245763 KORB map00020,map00720,map01100,map01120 C 2-oxoglutarate ferredoxin oxidoreductase subunit beta COG1013 Cluster_255233 V1245764 MRR V restriction COG1715 Cluster_401839 V1245765 K Transcriptional regulator, TetR family 0XUF9 Cluster_751608 V1245767 S NA 0Z34Z Cluster_46927 V1245768 S NA 0ZTYV Cluster_126811 V1245771 L Phage terminase, large subunit COG1783 Cluster_261696 V1245774 YHCC S Radical SAM Protein COG1242 Cluster_674305 V1245775 RPSJ map03010 J Involved in the binding of tRNA to the ribosomes (By similarity) COG0051 Cluster_392997 V1245776 RPLC map03010 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 Cluster_489691 V1245777 RPLD map03010 J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) COG0088 Cluster_272410 V1245778 YPJC S YitT family COG1284 Cluster_766333 V1245780 SP_1801 S integral membrane protein COG2261 Cluster_400058 V1245781 DEF J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) COG0242 Cluster_272411 V1245782 GLYQ map00970 J glycyl-tRNA synthetase, alpha subunit COG0752 Cluster_206155 V1245783 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_155303 V1245784 V Restriction modification system DNA (Specificity COG0732 Cluster_154469 V1245785 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_142008 V1245788 map02010 M abc transporter permease protein COG4591 Cluster_144234 V1245789 CAPA M Capsule synthesis protein COG2843 Cluster_528910 V1245791 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_173725 V1245793 P Transporter COG0733 Cluster_573289 V1245799 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_131138 V1245800 map03420,map03430 L helicase COG0210 Cluster_631968 V1024401 RBFA J Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) COG0858 Cluster_353452 V1024403 S NA 11F7I Cluster_792176 V1024406 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_353453 V1024414 S NA 0YCCW Cluster_415807 V1024415 S FR47-like protein 11TPW Cluster_353454 V1024416 M Alpha beta hydrolase fold COG1073 Cluster_572453 V1024417 BATB S von Willebrand factor, type A COG2304 Cluster_355038 V1024418 HSDM V Type I restriction-modification system, M subunit COG0286 Cluster_484473 V1024420 HYMB map00190,map00910,map01100 C NADH dehydrogenase COG1894 Cluster_371636 V1024421 M Inherit from NOG: Polymorphic outer membrane protein 11KKP Cluster_355039 V1024425 P tonB-dependent Receptor 1AJ2A@sphNOG Cluster_776551 V1024427 TNP L transposase COG3316 Cluster_575680 V1024428 DEDA P SNARE associated Golgi COG0586 Cluster_494060 V1024434 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) COG0167 Cluster_517250 V1024439 MRCA map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_355040 V1024440 S Inherit from NOG: antigen PG97 COG4886 Cluster_765314 V1024441 BL01373 L Integrase COG0582 Cluster_356753 V1024442 MGTA P magnesium-translocating P-type ATPase COG0474 Cluster_356754 V1024443 P TonB-dependent receptor Plug 0XNPQ Cluster_364943 V1024444 NORM V MATE efflux family protein COG0534 Cluster_875063 V1024448 YHDG E amino acid COG0531 Cluster_446579 V1024449 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_664541 V1024451 S Protein of unknown function (DUF1811) 0XYU6 Cluster_356755 V1024452 map03070 U conjugation trbi family protein COG2948 Cluster_514533 V1024454 MLL7993 V Hnh endonuclease COG3183 Cluster_916697 V1024455 RPMC map03010 J 50s ribosomal protein l29 COG0255 Cluster_720790 V1024456 RPSQ map03010 J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal COG0186 Cluster_613277 V1024459 S NA 0ZHU9 Cluster_358447 V1024463 AASI_0454 S NA 0XPYJ Cluster_624507 V1024464 YCIC S cobalamin synthesis protein P47K COG0523 Cluster_381960 V1024465 QUEC map00790,map01100 S Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) COG0603 Cluster_358448 V1024466 T serine threonine protein kinase COG0515 Cluster_358449 V1024467 S Caudovirus prohead protease 12923 Cluster_358450 V1024468 S NA 0ZTYV Cluster_358451 V1024471 S NA 121ZU Cluster_444564 V1024472 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_509306 V1024476 TCAR K Transcriptional regulator 0XUB6 Cluster_358452 V1024478 S NA 12D73 Cluster_360094 V1024479 S NA 11EKV Cluster_522532 V1024481 map00230 S Metal Dependent Phosphohydrolase 11UWJ Cluster_562974 V1024482 BMUL_6158 K TetR family transcriptional regulator COG1309 Cluster_796125 V1024483 PCM O O-methyltransferase COG2518 Cluster_442555 V1024491 PORG map00020,map00720,map01100,map01120 C oxidoreductase COG1014 Cluster_360095 V1024493 S domain protein 0YNW0 Cluster_517251 V1024496 S Septum formation 0Y0EZ Cluster_677642 V1024501 UGPC map02010 G (ABC) transporter COG3839 Cluster_517252 V1024502 S NA 0Z5C1 Cluster_423009 V1024504 MRP D ATP-binding protein COG0489 Cluster_695153 V1024505 YDCP map05120 O Peptidase, U32 family COG0826 Cluster_361659 V1024508 PHND map02010 P phosphonate ABC transporter, periplasmic phosphonate-binding protein COG3221 Cluster_361660 V1024512 QUEG C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) COG1600 Cluster_419291 V1024514 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_361661 V1024515 U, W Inherit from COG: domain protein COG5295 Cluster_613278 V1024520 ARSC P Transcriptional regulator, Spx MgsR family COG1393 Cluster_436509 V1024524 map00511 G glycoside hydrolase family 38 COG0383 Cluster_494061 V1024527 PSCB N, U domain protein COG3942 Cluster_361662 V1024528 RPSA map00900,map01100,map01110,map03010 J Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) COG0761 Cluster_677643 V1024532 RPLW map03010 J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) COG0089 Cluster_635924 V1024535 YAIZ S Membrane 17HMA@proNOG Cluster_363235 V1024536 HELY L helicase COG4581 Cluster_628204 V1024538 ISCA O iron--sulfur cluster insertion protein erpA COG0316 Cluster_438556 V1024541 BMUL_1405 P phosphate transport regulator COG1392 Cluster_924578 V1024542 PITA P phosphate transporter COG0306 Cluster_823834 V1024545 S Uncharacterized protein conserved in bacteria (DUF2187) COG4873 Cluster_419292 V1024547 K Phage regulatory protein Rha (Phage_pRha) COG3646 Cluster_530996 V1024549 P Ferric uptake 11J37 Cluster_401408 V1024550 S (LipO)protein 0XQ9B Cluster_364944 V1024551 SP_0341 S UPF0371 protein COG4868 Cluster_417564 V1024554 L Resolvase, N terminal domain COG1961 Cluster_421157 V1024556 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_489074 V1024557 SMPB O Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) COG0691 Cluster_412076 V1024560 L Dna topoisomerase COG0550 Cluster_380183 V1024565 RPRX map02020 T Histidine kinase COG5002 Cluster_509307 V1024566 S NA 0Z34Z Cluster_419293 V1024567 FTSQ map04112 S cell division protein 1AGSA@sphNOG Cluster_499206 V1024568 S NA 17U1N@proNOG Cluster_796126 V1024569 PILW U Type IV pilus assembly protein PilW COG4966 Cluster_383750 V1024570 map00130,map00362,map01100,map01110,map01120 I thioesterase COG1607 Cluster_364945 V1024571 MCM map00280,map00640,map00720,map01100,map01120 I Methylmalonyl-coA mutase COG2185 Cluster_364946 V1024572 S Oligopeptide transporter, Opt family COG1297 Cluster_602327 V1024577 K Transcriptional regulator, GntR family COG1725 Cluster_366695 V1024583 S Membrane 0ZQP3 Cluster_376676 V1024584 V Type I restriction modification DNA specificity domain COG0732 Cluster_765316 V1024585 P tonB-dependent Receptor 0XP5Y Cluster_366696 V1024586 FOLP map00790,map01100 H dihydropteroate synthase COG0294 Cluster_446580 V1024590 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_602328 V1024594 NADC map00760,map01100 H nicotinate-nucleotide pyrophosphorylase COG0157 Cluster_562975 V1024595 O OsmC-like protein 11EKI Cluster_533766 V1024596 S dNA-binding protein 0Y077 Cluster_850860 V1024597 L Pfam:Transposase_7 COG4644 Cluster_595276 V1024598 L Pfam:Transposase_7 COG4644 Cluster_45176 V1245801 S NA 101UU Cluster_157837 V1245803 GSPE map03070 U type ii secretion system protein e COG2804 Cluster_203990 V1245806 P abc transporter atp-binding protein COG1116 Cluster_249081 V1245807 FTSX map02010 D Part of the ABC transporter FtsEX involved in COG2177 Cluster_644923 V1245809 COAA map00770,map01100 H pantothenic acid kinase COG1072 Cluster_271080 V1245810 RSMI G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 Cluster_186496 V1245811 CARA map00240,map00250,map01100 F carbamoyl-phosphate synthetase glutamine chain COG0505 Cluster_81757 V1245812 M Inherit from COG: YD repeat protein COG3209 Cluster_326068 V1245815 SRTB U sortase, SrtB family COG4509 Cluster_401840 V1245816 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 C Phosphofructokinase COG0205 Cluster_251553 V1245817 PSTC map02010 P phosphate abc transporter COG0573 Cluster_172903 V1245818 PGCA map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_49587 V1245819 POLA_2 L DNA polymerase 0XRUF Cluster_268427 V1245821 SDAAA map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase COG1760 Cluster_365343 V1245822 SDAAB map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase, iron-sulfur-dependent, beta subunit COG1760 Cluster_674306 V1245823 NUOK map00190,map00910,map01100 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) COG0713 Cluster_445011 V1245824 NDHG map00190,map00910,map01100 C NADH-ubiquinone plastoquinone oxidoreductase chain 6 1208F Cluster_451045 V1245825 NUOI map00190,map00910,map01100 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) COG1143 Cluster_485052 V1245826 S NA 0Y3Q9 Cluster_579633 V1245827 S NA 0XUAX Cluster_412533 V1245828 T cyclic nucleotide-binding domain protein COG0664 Cluster_403620 V1245829 S NA 11SZV Cluster_480416 V1245830 FTNA map00860 P ferritin COG1528 Cluster_412534 V1245831 RNFE C Electron transport complex COG4660 Cluster_431024 V1245832 RNFG C Electron transport complex, RnfABCDGE type, G subunit COG4659 Cluster_225523 V1245833 S CAAX protease self-immunity 0XUJM Cluster_540211 V1245834 T Positive regulator of sigma(E), RseC/MucC 0ZZM5 Cluster_389455 V1245836 CZCD P cation diffusion facilitator family transporter COG1230 Cluster_141281 V1245837 GLTS E Sodium Glutamate Symporter COG0786 Cluster_352102 V1245838 CLPP_1 map04112 O ATP-dependent Clp protease, proteolytic subunit COG0740 Cluster_425228 V1245839 V restriction endonuclease COG0827 Cluster_389456 V1245840 RPLC map03010 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 Cluster_180345 V1245842 HOM map00260,map00270,map00300,map01100,map01110,map01120,map01230 E homoserine dehydrogenase COG0460 Cluster_649001 V1245843 COMM O Mg chelatase subunit ChlI COG0606 Cluster_492190 V1245844 M n-acetylmuramoyl-l-alanine amidase COG5632 Cluster_876046 V1245847 S NA 0ZIXX Cluster_326069 V1245848 PPID O Peptidyl-prolyl cis-trans isomerase COG0760 Cluster_194436 V1245849 PRSA O Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) COG0760 Cluster_384150 V1245850 RPLY map03010 J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) COG1825 Cluster_614264 V1245851 ARSC P Transcriptional regulator, Spx MgsR family COG1393 Cluster_375328 V1245852 S Nitrogen regulatory protein P-II 11PAT Cluster_227788 V1245853 FTSK D cell division protein FtsK COG1674 Cluster_170346 V1245854 YJIM E 2-hydroxyglutaryl-CoA dehydratase COG1775 Cluster_291323 V1245855 CLCAR_1091 T Histidine kinase COG0642 Cluster_338163 V1245856 CPN_0573 K transcriptional regulatory protein COG0217 Cluster_724972 V1245857 DEOC map00030 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) COG0274 Cluster_362033 V1245858 VICR map02020 T response regulator COG0745 Cluster_294058 V1245859 S hemolysin secretion protein 0XPDT Cluster_75791 V1245860 S domain protein 0YF83 Cluster_108811 V1245862 M Inherit from COG: YD repeat protein COG3209 Cluster_285959 V1245863 NADE map00760,map01100 H nh(3)-dependent nad( ) synthetase COG0171 Cluster_335085 V1245864 T response regulator COG2197 Cluster_86387 V1245865 M Glycosyl transferase (Group 1 0YE5J Cluster_47496 V1245867 COMEC S Competence protein COG2333 Cluster_265702 V1245868 RFBA map00521,map00523,map01100,map01110 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) COG1209 Cluster_641042 V1245869 RPLV map03010 J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) COG0091 Cluster_345776 V1245870 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_820849 V1245871 RPMC map03010 J 50s ribosomal protein l29 COG0255 Cluster_661418 V1245872 MUTL2 map00660,map01100 S glutamate mutase, mutL 0XRSI Cluster_94705 V1245873 MUTE map00660,map01100 E Methylaspartate mutase, E subunit COG4865 Cluster_492191 V1245874 MNME S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 Cluster_295466 V1245875 JAG S Single-stranded nucleic acid binding R3H domain-containing protein COG1847 Cluster_502378 V1245877 map00051,map00520,map01100,map02060 G PTS system sorbose subfamily IIB component COG3444 Cluster_702348 V1245878 TNP3509A L Transposase for insertion sequence element 0Z3DP Cluster_455006 V1245879 SP_1419 map00970,map01100 J acetyltransferase, (GNAT) family COG1670 Cluster_471554 V1245881 K RNA Polymerase 11MBG Cluster_53286 V1245882 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_122167 V1245884 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_259079 V1245886 S copper amine 121X1 Cluster_592744 V1245887 S Zn-finger containing protein 121ND Cluster_560832 V1245888 S isoprenylcysteine carboxyl methyltransferase family protein 0ZWP8 Cluster_392998 V1245889 S NA 11H00 Cluster_294059 V1245890 map00130,map00770,map01100,map01110 S Methyltransferase 0ZVQZ Cluster_217354 V1245891 GPSA map00564 C NADPH-dependent glycerol-3-phosphate dehydrogenase COG0240 Cluster_373619 V1245894 map02010 P ABC transporter COG1131 Cluster_350599 V1245895 S NA 0YJH0 Cluster_126812 V1245896 MVAA map00900,map01100,map01110,map04976 I hydroxymethylglutaryL-CoA reductase COG1257 Cluster_509972 V1245897 map00020,map00190,map00623,map00650,map00720,map00984,map01100,map01110,map01120,map02020 C Flavocytochrome c COG1053 Cluster_373620 V1245898 S NA 0ZP1D Cluster_363602 V1245900 ADDA L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation COG1074 Cluster_398322 V1245901 PGLC M Bacterial sugar transferase COG2148 Cluster_209418 V1245902 map00052,map00520,map01100,map01110 G, M epimerase COG0451 Cluster_781226 V1245903 SECE map03060,map03070 U preprotein translocase subunit SecE 0ZYWA Cluster_705446 V1245904 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_50166 V1245905 S Inherit from COG: leucine Rich Repeat COG4886 Cluster_50167 V1245907 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_348976 V1245908 L recombinase (Phage integrase family) COG0582 Cluster_373621 V1245909 FEMA map00550,map01100 V Methicillin resistance protein COG2348 Cluster_178647 V1245912 S YD repeat protein 0Z0FY Cluster_170347 V1245913 S Membrane COG0628 Cluster_99499 V1245918 S NA 11H22 Cluster_56510 V1245919 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_88127 V1245920 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_321425 V1245921 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_230119 V1245923 S NA 0YCTM Cluster_51528 V1245924 PPDK map00620,map00710,map01100,map01120 G pyruvate phosphate dikinase COG0574 Cluster_67153 V1245926 S NA 11YT1 Cluster_699281 V1245927 S Domain of unknown function (DUF1837) 11JZV Cluster_73523 V1245928 S phage Tail Protein 0Z1N7 Cluster_543113 V1245929 ATPC map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG0355 Cluster_117723 V1245930 HEML map00860,map01100,map01110 H Glutamate-1-semialdehyde aminotransferase COG0001 Cluster_291324 V1245933 map00230,map00240,map01100,map03030,map03430,map03440 L EXOIII COG2176 Cluster_88128 V1245934 ATPA map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_755081 V1245935 ATPG map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) COG0224 Cluster_770052 V1245936 E HAD-superfamily subfamily IB hydrolase COG0560 Cluster_202942 V1245937 DINB L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity) COG0389 Cluster_540212 V1245938 PAAI2 map00360 S Thioesterase superfamily protein 1292Y Cluster_73524 V1245939 HCP C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) COG1151 Cluster_458929 V1245940 U Biopolymer transport protein exbD tolR 11JQD Cluster_482735 V1245943 S OsmC-like protein 124NV Cluster_669913 V1245944 OCAR_7462 map00270,map00450,map01100,map01110,map01230 E Methionine synthase COG0620 Cluster_378882 V1245945 V Mate efflux family protein COG0534 Cluster_180346 V1245946 T response regulator COG2208 Cluster_339585 V1245947 ZNUA map02010 P transporter substrate-binding protein COG0803 Cluster_169477 V1245948 V ABC transporter, permease COG0577 Cluster_259080 V1245949 UDK map00240,map00710,map00983,map01100,map01120 F uridine monophosphokinase COG0572 Cluster_299484 V1245950 MANM map00051,map00520,map01100,map02060 G PTS System COG3715 Cluster_76100 V1245951 S S-layer domain protein 12C8X Cluster_89065 V1245952 map02010 V ABC transporter COG1132 Cluster_384151 V1245953 S Protein of unknown function (DUF1638) 11HVD Cluster_499847 V1245954 VBSC S Gnat family COG0456 Cluster_489692 V1245955 PHBA map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map02020 I acetyl-CoA COG0183 Cluster_217355 V1245956 PHAJ I MaoC domain protein dehydratase COG2030 Cluster_797095 V1245957 GLTC K transcriptional regulator COG0583 Cluster_391184 V1245958 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG0194 Cluster_160400 V1245959 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_678759 V1245962 YJJH S Phosphohydrolase COG1409 Cluster_54035 V1245965 map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_139794 V1245966 V abc transporter permease protein 0ZW5X Cluster_365344 V1245967 S integral membrane protein 11TVJ Cluster_336615 V1245968 CPN_0573 K transcriptional regulatory protein COG0217 Cluster_385927 V1245969 MURE map00300,map00550,map01100 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_156969 V1245970 DACA map00550,map01100 M carboxypeptidase COG1686 Cluster_425229 V1245971 S Transcription termination antitermination factor NusG 0YUUM Cluster_387750 V1245972 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_133494 V1245973 GLMU map00520,map01100,map01110 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) COG1207 Cluster_238631 V1245974 M Nlp p60 protein COG0791 Cluster_777469 V1245975 OCAR_6158 L Terminase, large subunit COG4626 Cluster_494671 V1245976 S Phage terminase small subunit COG3747 Cluster_114896 V1245980 MESE map02020,map03070,map05133 U Transport protein ComB 0XX01 Cluster_657208 V1245981 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Involved in acetate metabolism (By similarity) COG0280 Cluster_85120 V1245982 BPET1060 L RNA-directed DNA polymerase COG3344 Cluster_844187 V1245987 K Transcriptional regulator, TetR family 0YTCU Cluster_75471 V1245988 map02010 V ABC transporter COG1132 Cluster_177808 V1245989 PARC L DNA topoisomerase IV, subunit A COG0188 Cluster_215023 V1245992 GAP map00010,map01100,map01110,map01120,map01230,map04066,map05010 G glyceraldehyde-3-phosphate dehydrogenase COG0057 Cluster_68570 V1245993 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_55247 V1245994 PRIA map03440 L Primosomal protein n' COG1198 Cluster_55248 V1245995 S s-layer domain-containing protein 11ZJU Cluster_218489 V1245997 YQFA S UPF0365 protein COG4864 Cluster_452987 V1245998 MODC map02010 P ABC transporter COG3842 Cluster_360456 V1245999 MODB map02010 P molybdate abc transporter COG4149 Cluster_669914 V1246000 map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_117005 V1246002 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_582876 V1246003 YAAA S S4 domain protein YaaA COG2501 Cluster_641044 V1246005 S cupin domain protein 11XEB Cluster_86388 V1246006 POLA_2 L DNA polymerase 0XRUF Cluster_316878 V1246007 ACIN_0074 L Transposase COG3464 Cluster_352104 V1246008 S NA 11IYN Cluster_531728 V1246009 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_687729 V1246011 RPSP map03010 J 30s ribosomal protein S16 COG0228 Cluster_246507 V1246012 LMB map02010 P periplasmic solute binding protein COG0803 Cluster_189035 V1246013 NYLB map00311,map00312,map01110,map02020 V beta-lactamase COG1680 Cluster_367055 V1246014 RESD map02020 T response regulator COG0745 Cluster_280397 V1246015 SP_0742 S degv family COG1307 Cluster_423423 V1246016 SP_0743 K Transcriptional regulator COG1309 Cluster_148835 V1246017 S hi0933 family COG2081 Cluster_183821 V1246018 YERB S secreted protein 11FHM Cluster_480417 V1246019 S NA 0ZTS3 Cluster_133495 V1246020 L Phage integrase family COG4974 Cluster_832372 V1246021 RPMF map03010 J 50S ribosomal protein L32 0ZX13 Cluster_155304 V1246022 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_183822 V1246024 S Relaxase mobilization nuclease 0Y9PG Cluster_355429 V1246026 TRMK S SAM-dependent methyltransferase COG2384 Cluster_751610 V1246027 MTA K Transcriptional regulator COG0789 Cluster_88580 V1246028 HSDM V type I restriction-modification system COG0286 Cluster_85121 V1246030 DLTA map00473,map05150 H Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) COG1020 Cluster_439037 V1246031 S structural protein 11RQ6 Cluster_637055 V1246032 S NA 0Y66R Cluster_770053 V1246033 S NA 0Y53Q Cluster_596214 V1246034 S NA 1246I Cluster_226646 V1246036 SCLAV_3941 O Band 7 protein COG0330 Cluster_669915 V1246037 S excisionase 0YX4W Cluster_265703 V1246041 YOJN S ATPase associated with various cellular activities aaa_5 COG0714 Cluster_596215 V1246042 S NA 0YWK8 Cluster_884247 V1246043 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_567003 V1246044 CDD map00240,map00983,map01100,map05219 F cytidine deaminase COG0295 Cluster_641045 V1246045 YBEY map00240,map00983,map01100 F Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) COG0319 Cluster_117006 V1246046 G Major Facilitator COG0477 Cluster_534524 V1246047 S NA 0XPGY Cluster_322988 V1246048 S NA 0Y8I8 Cluster_487342 V1246050 F HDc COG0232 Cluster_182100 V1246051 RV1290C S Membrane COG4325 Cluster_517912 V1246052 ARSD P Arsenical resistance operon tranS-acting repressor 11UF3 Cluster_118412 V1246054 CIAH map02020 T Histidine kinase COG0642 Cluster_209419 V1246056 GPSA map00564 C NADPH-dependent glycerol-3-phosphate dehydrogenase COG0240 Cluster_117007 V1246057 map03420,map03430 L UvrD REP helicase COG0210 Cluster_339587 V1246058 S NA 123FT Cluster_85922 V1246059 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_130360 V1246060 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_820851 V1246061 XSEB map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) 0XUAP Cluster_96824 V1246062 K, L domain protein COG0553 Cluster_531729 V1246064 S NA 11TBU Cluster_341048 V1246066 GLNN map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG3968 Cluster_644924 V1246067 LEBU_0481 L Transposase COG1943 Cluster_307894 V1246068 RPSB map03010 J 30S ribosomal protein S2 COG0052 Cluster_380606 V1246069 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_74189 V1246070 MUTL2 map00660,map01100 S glutamate mutase, mutL 0XRSI Cluster_288728 V1246072 LPCA M Glycosyl transferase family 8 COG1442 Cluster_226647 V1246073 YHAO L DNA repair exonuclease COG0420 Cluster_439038 V1246074 ENTB Q Isochorismatase, hydrolase 11I3F Cluster_363603 V1246076 KTRA P domain protein COG0569 Cluster_171987 V1246078 HTH_0473 L Transposase COG0675 Cluster_189902 V1246079 HCAN_0220 S Pfam:DUF395 0XPA5 Cluster_789345 V1246080 map04122 S SirA family 0XX39 Cluster_781227 V1246083 VORD map00020,map00720,map01100,map01120 C 4Fe-4S Ferredoxin, iron-sulfur binding domain protein COG1146 Cluster_355430 V1246084 S atp gtp-binding protein 11QV4 Cluster_295467 V1246086 PS609 L Bifunctional DNA primase polymerase 11IQM Cluster_557783 V1246087 T Response Regulator COG0745 Cluster_417989 V1246088 PPIB O PPIases accelerate the folding of proteins COG0652 Cluster_389458 V1246089 TDK map00240,map00983,map01100 F thymidine kinase COG1435 Cluster_674307 V1246090 S Bacterial protein of unknown function (DUF898) 11UV5 Cluster_702350 V1246091 L NA 0YKV1 Cluster_560833 V1246093 C, O redox-active disulfide protein 2 COG0526 Cluster_96825 V1246094 S NA 11GMQ Cluster_368664 V1246096 S Pfam:DUF88 COG1432 Cluster_322989 V1246097 XTH map03410 L Exodeoxyribonuclease III COG0708 Cluster_683300 V1246098 RPOZ map00230,map00240,map01100,map03020 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) COG1758 Cluster_396599 V1246099 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG0194 Cluster_324571 V1246100 YICC map03010 S YicC domain protein COG1561 Cluster_233724 V1246101 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_254022 V1246103 G Exopolysaccharide biosynthesis protein COG4632 Cluster_801034 V1246104 U Type IV secretory pathway VirD4 COG3505 Cluster_350600 V1246105 GLPQ map00564 C glycerophosphoryl diester phosphodiesterase COG0584 Cluster_382382 V1246106 map00630,map01100,map01110 F IA, variant 1 COG0546 Cluster_249082 V1246107 S tetrapyrrole methylase COG3956 Cluster_109444 V1246108 SUFB O FeS assembly protein SUFB COG0719 Cluster_509973 V1246109 S membrAne 120XT Cluster_368665 V1246110 UDK map00240,map00983,map01100 F uridine monophosphokinase COG0572 Cluster_168548 V1246112 S NA 11QZ9 Cluster_657209 V1246113 S PEP phosphonomutase family protein 0XPW8 Cluster_138255 V1246114 CELB map00052,map01100,map02060 G Pts system COG1455 Cluster_98443 V1246115 ASPA map00250,map00910,map01100 E Aspartate ammonia-lyase COG1027 Cluster_254023 V1246116 K Transcriptional regulator 11KHV Cluster_695993 V1246117 K Transcriptional regulator 11GAC Cluster_431025 V1246118 PTH J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) COG0193 Cluster_534525 V1246119 S Protein of unknown function (DUF3021) 124CX Cluster_528912 V1246120 K lytTr DNA-binding domain protein 11WH8 Cluster_606933 V1246121 V VanZ-like protein COG4767 Cluster_63754 V1246123 S NA 11NI8 Cluster_74190 V1246124 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 Cluster_439039 V1246125 THIT S Proton-coupled thiamine transporter YuaJ COG3859 Cluster_724973 V1246126 D, J addiction module toxin, RelE StbE family COG2026 Cluster_781228 V1246127 S NA 125R4 Cluster_327624 V1246128 LGT M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 Cluster_110753 V1246129 HRM2_08390 L transposase (IS4 family) protein 0XQ88 Cluster_528913 V1246130 NADE map00760,map01100 H Nad synthetase COG0171 Cluster_355431 V1246131 OCAR_4872 M integral membrane protein COG1814 Cluster_268428 V1246132 S Protein of unknown function (DUF3298) 11R45 Cluster_174542 V1246134 MRDB M Rod shape-determining protein rodA COG0772 Cluster_567004 V1246136 T anti-sigma regulatory factor serine threonine protein kinase 11VVV Cluster_347367 V1246137 S Copper amine oxidase N-terminal domain 12921 Cluster_633011 V1246139 HIT map00230,map00240 F, G histidine triad (hIT) protein COG0537 Cluster_335086 V1246140 XERD L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) COG0582 Cluster_345777 V1246141 SCPA S Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) COG1354 Cluster_344162 V1246142 RSMG M Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) COG0357 Cluster_392999 V1246145 L Replication Protein 0YRQ2 Cluster_482736 V1246146 S ybak prolyl-trna synthetase COG3760 Cluster_817011 V1246147 YRKF P Rhodanese domain protein COG0607 Cluster_181168 V1246148 BMPA S basic membrane COG1744 Cluster_629156 V1246149 K Transcriptional regulator PadR-like family COG1695 Cluster_499848 V1246150 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG2812 Cluster_303695 V1246152 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_661419 V1246153 G Tripartite ATP-independent periplasmic transporter dctq component COG3090 Cluster_133496 V1246154 map02020 G trap dicarboxylate transporter dctm subunit COG1593 Cluster_66290 V1246155 CAS3 L CRISPR-Associated Helicase Cas3 COG1203 Cluster_357125 V1246157 NUC L nuclease COG1525 Cluster_403621 V1246158 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_205070 V1246159 S NA 11VIT Cluster_192617 V1246160 S S-layer homology domain 123R1 Cluster_579634 V1246161 K Transcriptional regulator COG3682 Cluster_139011 V1246162 K, T Peptidase m56 COG4219 Cluster_683301 V1246163 SP_0275 L Addiction module antitoxin, RelB DinJ family COG3077 Cluster_711681 V1246164 SP_0276 S addiction module toxin, RelE StbE family COG3041 Cluster_421561 V1246167 RNFA C Electron transport complex COG4657 Cluster_695994 V1246168 RNFE C Electron transport complex COG4660 Cluster_391185 V1246171 T cyclic nucleotide-binding domain protein COG0664 Cluster_471555 V1246173 RPSE map03010 J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) COG0098 Cluster_603297 V1246174 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_193502 V1246175 SELD map00450,map01100 E Synthesizes selenophosphate from selenide and ATP (By similarity) COG0709 Cluster_467277 V1246176 V ABC transporter, ATP-binding protein COG1132 Cluster_489693 V1246178 S NA 0YR8M Cluster_546062 V1246179 RPLM map03010 J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) COG0102 Cluster_557784 V1246180 RPSI map03010 J 30S ribosomal protein S9 COG0103 Cluster_603298 V1246181 S NA 11XW5 Cluster_751611 V1246182 LMRA V ABC transporter COG1132 Cluster_224354 V1246183 S Membrane 11QY1 Cluster_512543 V1246184 P SNARE associated Golgi protein COG1238 Cluster_148836 V1246185 S NA 0XWEM Cluster_256467 V1246187 S copper amine 0XP8R Cluster_234918 V1246188 L site-specific recombinase, phage integrase family 0ZJK4 Cluster_606934 V1246189 S NA 0YHT6 Cluster_692224 V1246190 S NA 0YK6Z Cluster_449078 V1246191 NUDF map00230 F nudix hydrolase COG0494 Cluster_403622 V1246192 SPOIVFB S Peptidase M50 COG1994 Cluster_154470 V1246193 YVRC map02010 P Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) COG0614 Cluster_208378 V1246194 YHEH V ABC transporter COG1132 Cluster_534526 V1246195 S Peptidase family M50 0Z3K7 Cluster_327625 V1246197 S Lpxtg-motif cell wall anchor domain protein 0Y44U Cluster_231296 V1246198 M YD repeat protein COG3209 Cluster_152898 V1246199 S ATPase (AAA COG1373 Cluster_657210 V1246200 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_728272 V1246202 YLXR K Nucleic-acid-binding protein implicated in transcription termination COG2740 Cluster_173726 V1246203 NUSA K Transcription elongation factor NusA COG0195 Cluster_210499 V1246204 CAS1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) COG1518 Cluster_138256 V1246206 GLUD map00250,map00330,map00430,map00471,map00910,map01100,map04964 E Glutamate dehydrogenase COG0334 Cluster_452988 V1246207 map00670,map01100 H 5-formyltetrahydrofolate cyclo-ligase COG0212 Cluster_107065 V1246209 PEPP E peptidase, M24 COG0006 Cluster_502379 V1246210 NUSB K Involved in the transcription termination process (By similarity) COG0781 Cluster_665630 V1246212 RPSP map03010 J 30s ribosomal protein S16 COG0228 Cluster_147306 V1246213 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_347368 V1246214 MAEB map00620,map00710,map01100,map01120 C Malic enzyme COG0281 Cluster_156970 V1246215 COABC map00770,map01100 H Phosphopantothenoylcysteine decarboxylase COG0452 Cluster_209420 V1246216 HRCA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) COG1420 Cluster_458930 V1246217 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_805230 V1246218 RPSA map00900,map01100,map01110,map03010 J Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) COG0539 Cluster_250333 V1246220 BCRA map02010 V ABC transporter COG1131 Cluster_299485 V1246221 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_326070 V1246222 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_121406 V1246223 DACA map00550,map01100 M carboxypeptidase COG1686 Cluster_219644 V1246224 YVBT C Luciferase family COG2141 Cluster_475815 V1246225 YTSP T gaf domain protein COG1956 Cluster_475816 V1246226 S NA 0Y6PA Cluster_227789 V1246229 TRXB map00240,map00450 C ferredoxin--nadp reductase COG0492 Cluster_221993 V1246230 SPPA O, U Signal peptide peptidase, SppA COG0616 Cluster_504783 V1246231 YTEJ S rdd domain containing protein COG1714 Cluster_355432 V1246232 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_762380 V1246233 PGN_0946 S Membrane COG1033 Cluster_342562 V1246234 S TraX protein 11MFB Cluster_534527 V1246236 S Protein of unknown function (DUF3737) 0XTHF Cluster_384152 V1246237 SDPI S Membrane COG5658 Cluster_416186 V1246238 ENGB S Necessary for normal cell division and for the maintenance of normal septation (By similarity) COG0218 Cluster_398323 V1246239 K Transcriptional regulator COG1309 Cluster_880096 V1246240 map00130 S (NAD(P)H dehydrogenase) (Quinone) COG2249 Cluster_567005 V1246241 BL03025 map00130 S (NAD(P)H dehydrogenase) (Quinone) COG2249 Cluster_232462 V1246242 RBSC-2 S abc transporter, permease COG1079 Cluster_96304 V1246243 CSTA T Carbon starvation protein CstA COG1966 Cluster_186497 V1246244 DNAB map03030,map04112 L Replicative dna helicase COG1372 Cluster_198911 V1246245 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_247763 V1246247 S NA 11G8Y Cluster_586071 V1246252 YGDL H uba thif-type nad fad binding protein COG1179 Cluster_793121 V1246254 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_434937 V1246255 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_348977 V1246256 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_546063 V1246257 V abc transporter permease protein 0XQE2 Cluster_353763 V1246258 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_106426 V1246260 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 Cluster_291325 V1246261 YMFM S Transcriptional regulator COG1426 Cluster_310759 V1246262 SUHB map00521,map00562,map00920,map01100,map01110,map01120,map04070 G inositol monophosphatase COG0483 Cluster_618021 V1246269 DARB map00061,map01100 I synthase III COG0332 Cluster_456946 V1246270 LEPB map03060 U Signal peptidase i COG0681 Cluster_336616 V1246271 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_318459 V1246272 S NA 0YV35 Cluster_471556 V1246276 RIMM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) COG0806 Cluster_329113 V1246277 TRMD map00900,map01100,map01110 J Specifically methylates guanosine-37 in various tRNAs (By similarity) COG0336 Cluster_674308 V1246278 RSBV T stage II sporulation protein COG1366 Cluster_79161 V1246279 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_599725 V1246280 RSFS S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) COG0799 Cluster_112056 V1246281 S atpase, aaa COG1373 Cluster_179516 V1246282 MURG map00550,map01100,map04112 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) COG0707 Cluster_789348 V1246284 YAAA S s4 domain protein COG2501 Cluster_184703 V1246285 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_721623 V1246286 S hi0933 family COG2081 Cluster_367056 V1246287 SRTA M (sortase) family COG3764 Cluster_245180 V1246289 BL05135 L integrase family COG4973 Cluster_649004 V1246290 S NA 129EW Cluster_482737 V1246291 S NA 11R41 Cluster_236117 V1246292 INSI L transposase COG2826 Cluster_358794 V1246293 RPOS map05111 K RNA polymerase sigma COG0568 Cluster_368666 V1246294 S dedA family COG0586 Cluster_377095 V1246295 MURE map00300,map00550 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_209421 V1246296 RARA L recombination factor protein RarA COG2256 Cluster_254024 V1246297 MIDI_00056 L Transposase 0YEAS Cluster_449079 V1246298 DESOR_0674 L Integrase catalytic subunit COG4584 Cluster_338164 V1246299 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_711682 V1246300 HSDR V Type I Restriction COG0610 Cluster_135079 V1246301 L Inherit from COG: Resolvase COG1961 Cluster_108812 V1246302 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_202943 V1246303 YCEG F aminodeoxychorismate lyase COG1559 Cluster_471557 V1246307 MRED S Rod shape-determining protein MreD 1267M Cluster_417990 V1246308 C Electron transport complex COG4659 Cluster_410721 V1246309 RNFE C Electron transport complex COG4660 Cluster_108813 V1246310 ICTB M O-Antigen polymerase COG3307 Cluster_225524 V1246311 PHOH T Phoh family COG1702 Cluster_296813 V1246313 RGPC map02010 V ABC-2 type transporter COG1682 Cluster_329114 V1246314 CPN_0573 K transcriptional regulatory protein COG0217 Cluster_372002 V1246315 S integral membrane protein 11TVJ Cluster_137491 V1246317 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_365345 V1246318 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_100023 V1246319 SCLAV_4792 G Major Facilitator superfamily 0XQD0 Cluster_567006 V1246320 map00051,map00520,map01100 M RmlD substrate binding domain COG1089 Cluster_589375 V1246321 S mobilization protein 11J0G Cluster_230120 V1246322 MRAY map00550,map01100 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) COG0472 Cluster_321426 V1246323 S NADP-dependent L-serine L-allo-threonine dehydrogenase YdfG COG4221 Cluster_145735 V1246324 V Restriction modification system DNA (Specificity COG0732 Cluster_296814 V1246326 HALSA_0542 L Transposase COG2801 Cluster_208379 V1246327 INSI L transposase COG2826 Cluster_507368 V1246329 S Protein of unknown function (DUF3408) 11QAR Cluster_370364 V1246330 S Tetratricopeptide repeat protein 0XZXZ Cluster_287365 V1246331 K Transcriptional regulator, ARAC family 125DJ Cluster_250334 V1246332 PURF map00230,map00250,map01100,map01110 F glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_421562 V1246333 CZCD P cation diffusion facilitator family transporter COG1230 Cluster_549099 V1246334 TETP T Tetracycline resistance protein COG0480 Cluster_350601 V1246335 S NA 123RZ Cluster_721624 V1246336 YTFP S hi0933 family COG2081 Cluster_396600 V1246337 CMK map00240,map00410,map00770,map01100,map01110 F Cytidine monophosphate kinase COG0283 Cluster_417991 V1246338 PLSC map00561,map00564,map01100 I Acyl-transferase COG0204 Cluster_126813 V1246340 DEOA map00240,map00983,map01100,map05219 F The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) COG0213 Cluster_741544 V1246341 SPOIVFB S Peptidase M50 COG1994 Cluster_260384 V1246343 S PEP phosphonomutase family protein 0XPW8 Cluster_497182 V1246344 GPO map00480,map00590 O Glutathione peroxidase COG0386 Cluster_718317 V1246345 O Glutaredoxin COG4545 Cluster_551980 V1246346 S NA 125EB Cluster_407100 V1246347 S NA 0XTKR Cluster_766335 V1246348 S NA 0XW6Y Cluster_741545 V1246349 S NA 0XWKC Cluster_384153 V1246350 YLME F alanine racemase domain protein COG0325 Cluster_372003 V1246351 GATB map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 Cluster_139795 V1246352 MTAD F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) COG0402 Cluster_166895 V1246354 BA_0233 P abc transporter, permease COG1173 Cluster_175356 V1246355 BPET1060 L DNA polymerase COG3344 Cluster_449080 V1246357 YWLG S UPF0340 protein COG4475 Cluster_515243 V1246358 CLOSA_1745 L transposase COG2963 Cluster_335087 V1246359 BCELL_1025 L Transposase COG2801 Cluster_260385 V1246361 ALKA map03410 L 8-oxoguanine DNA glycosylase COG0122 Cluster_180347 V1246362 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_456947 V1246363 YOJN S ATPase associated with various cellular activities aaa_5 COG0714 Cluster_758597 V1246365 FABG map00061,map00780,map01040,map01100 I reductase 0XNW1 Cluster_410722 V1246366 RUVA map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) COG0632 Cluster_259081 V1246367 S NA 120GN Cluster_467279 V1246370 S Phosphodiesterase, mj0936 family 11FUN Cluster_309313 V1246371 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_122168 V1246373 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_576519 V1246374 ICTB M O-Antigen polymerase COG3307 Cluster_181169 V1246375 CSAB M Polysaccharide pyruvyl transferase COG2327 Cluster_322990 V1246377 S SNARE-like domain protein 0XUKY Cluster_108814 V1246378 NHAC-1 map00680 C Na H antiporter COG1757 Cluster_276423 V1246380 S NA 0Y9TN Cluster_425230 V1246381 S PemK-like protein 0XVQI Cluster_284515 V1246384 LACT K antiterminator COG3711 Cluster_307895 V1246385 SP_1731 S Membrane COG2966 Cluster_487344 V1246386 S Membrane Spanning Protein COG3610 Cluster_84722 V1246387 E oligoendopeptidase, m3 family COG1164 Cluster_84723 V1246388 DPNA L helicase COG4646 Cluster_341049 V1246389 COBJ map00860,map01100 H Precorrin-3B C17-methyltransferase COG1010 Cluster_280398 V1246390 OWEHO_0257 L Integrase COG2801 Cluster_884249 V1246391 S Acetyltransferase (GNAT) family 0XTZG Cluster_154471 V1246392 WBBL M Glycosyl transferase, family 2 COG1216 Cluster_190760 V1246393 B, K radical SAM domain protein COG1243 Cluster_504784 V1246394 SP_1619 map00051,map01100,map02060 G PTS IIA-like nitrogen-regulatory protein PtsN COG1762 Cluster_596216 V1246396 M efflux transporter, outer membrane factor lipoprotein, NodT family COG1538 Cluster_393000 V1246397 VRAR map02020 T response regulator COG2197 Cluster_156971 V1246400 COABC map00770,map01100 H Phosphopantothenoylcysteine decarboxylase COG0452 Cluster_504785 V1246402 I PAP2 Family COG0671 Cluster_551981 V1246403 S ATPase (AAA COG1373 Cluster_649005 V1246404 OGT L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) COG0350 Cluster_614265 V1246405 ARSC P Transcriptional regulator, Spx MgsR family COG1393 Cluster_276424 V1246406 S NA 0Y056 Cluster_478014 V1246407 SP_0119 L Nudix family COG0494 Cluster_407101 V1246408 VANSB T Histidine kinase 0XNMH Cluster_352105 V1246409 SP_0793 map00061,map00780,map01040,map01100 I, Q oxidoreductase, short- chain dehydrogenase reductase COG1028 Cluster_801035 V1246410 CSPA K Cold shock protein COG1278 Cluster_460982 V1246411 map02010 V Abc transporter COG1132 Cluster_225525 V1246412 V ABC transporter COG1132 Cluster_460983 V1246414 S Acetyltransferase (GNAT) family 1029K Cluster_159554 V1246415 DING L helicase COG1199 Cluster_517913 V1246416 S relaxase mobilization nuclease domain protein 0XNXG Cluster_327626 V1246417 M (sortase) family COG3764 Cluster_751612 V1246418 S UPF0473 protein 0Z6ED Cluster_549100 V1246419 RUVX L Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) COG0816 Cluster_191677 V1246420 PHAC map00350,map00362,map00627,map00642,map00650,map00903,map01120 I poly(r)-hydroxyalkanoic acid synthase, class COG3243 Cluster_140528 V1246422 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_178648 V1246424 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_330519 V1246425 NIFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_401841 V1246426 PYRB map00240,map00250,map01100 F aspartate transcarbamylase COG0540 Cluster_421563 V1246428 S ykgG family 11JYM Cluster_579635 V1246429 COMGC map02020,map03070 U Competence protein 0XUCS Cluster_419768 V1246431 M NA 11FBZ Cluster_89979 V1246433 S NA 0YAQZ Cluster_629157 V1246434 CELAL_0017 S NA 11TT6 Cluster_110754 V1246436 DUSB J Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_238632 V1246437 TRXB map00240,map00450 O thioredoxin reductase COG0492 Cluster_836264 V1246438 TRXA O Thioredoxin COG0526 Cluster_225526 V1246439 ATU2672 S ABC transporter COG2984 Cluster_417992 V1246440 CASB S CRISPR system CASCADE complex protein CasB 0ZXJT Cluster_460984 V1246442 WCFS map00051 M Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase COG2148 Cluster_91391 V1246444 M Cell wall anchor domain protein 11Q8J Cluster_537412 V1246446 S NA 0YIEB Cluster_183823 V1246447 U TraG family COG3505 Cluster_419769 V1246448 S NA 11VIE Cluster_288729 V1246449 NFO map03410 L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) COG0648 Cluster_92370 V1246451 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_173727 V1246453 BCGIA V Type II restriction modification enzyme methyltransferase COG0286 Cluster_403623 V1246454 S NA 11FFJ Cluster_385928 V1246455 K Transcriptional regulator, TetR family 11IXV Cluster_327627 V1246456 FABG map00061,map00780,map01040,map01100 I 3-oxoacyl- acyl-carrier-protein reductase 0XNW1 Cluster_509974 V1246460 S Protein of unknown function (DUF3408) 11QAR Cluster_504786 V1246462 K transcriptional regulator 11Z66 Cluster_92821 V1246463 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0587 Cluster_322991 V1246464 S copper amine oxidase 0ZVY0 Cluster_817013 V1246465 RPMI map03010 J 50s ribosomal protein L35 COG0291 Cluster_494672 V1246466 DEF J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) COG0242 Cluster_515244 V1246467 PRIA map03440 L Primosomal protein n' COG1198 Cluster_517914 V1246470 DTD J Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) COG1490 Cluster_234919 V1246471 LACD map00052,map01100 G Aldolase COG3684 Cluster_348978 V1246472 S Membrane 11U5A Cluster_95715 V1246473 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_382383 V1246476 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_95213 V1246477 V ABC transporter COG1132 Cluster_721625 V1246478 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_96305 V1246479 S NA 0YHNP Cluster_246508 V1246480 PYRB map00240,map00250,map01100 F aspartate transcarbamylase COG0540 Cluster_531731 V1246481 PYRI map00240,map00250,map01100 F Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) COG1781 Cluster_728274 V1246483 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_283142 V1246486 V Type III COG3587 Cluster_241184 V1246487 NUCA map04210 F DNA RNA NON-specific endonuclease COG1864 Cluster_412535 V1246490 FOLE map00790,map01100 H GTP cyclohydrolase i COG0302 Cluster_554878 V1246491 S NA 11YG8 Cluster_433023 V1246492 S NA 11YT1 Cluster_265704 V1246493 S conjugative transposon membrane protein 0XPC1 Cluster_596217 V1246494 S Protein of unknown function (DUF713) 0Y5I3 Cluster_152060 V1246496 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_789350 V1246497 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_236118 V1246498 MANA map00051,map00520,map01100,map01110 G mannose-6-phosphate isomerase COG1482 Cluster_410723 V1246499 QUEF map00790,map01100 S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) COG0780 Cluster_393001 V1246506 YTPR J TRNA binding domain protein COG0073 Cluster_389459 V1246507 RPIA map00030,map00710,map01100,map01110,map01120,map01230 G phosphoriboisomerase A COG0120 Cluster_504787 V1246508 NFED O nodulation efficiency protein D COG1030 Cluster_637056 V1246509 HIT map00230,map00240 F, G histidine triad (hIT) protein COG0537 Cluster_669918 V1246510 S tonB-dependent Receptor 0YAYV Cluster_127506 V1246511 DARB map00061,map01100 I synthase III COG0332 Cluster_268429 V1246512 RLUC J Pseudouridine synthase COG0564 Cluster_355433 V1246513 METI map02010 P ABC transporter, permease COG2011 Cluster_512544 V1246514 YUEI S Protein of unknown function (DUF1694) COG5506 Cluster_467280 V1246520 NUSB K Involved in the transcription termination process (By similarity) COG0781 Cluster_596218 V1246523 S membrAne 11GVZ Cluster_100572 V1246524 SASH map00230,map00240,map00760,map01100,map01110 F 5'-nucleotidase COG0737 Cluster_434938 V1246525 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_114897 V1246526 PEPC E aminopeptidase c COG3579 Cluster_848087 V1246528 THII map00730,map01100,map04122 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) COG0301 Cluster_755083 V1246529 S UPF0109 protein COG1837 Cluster_315358 V1246530 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_358795 V1246531 S NA 0ZVJP Cluster_242555 V1246533 CLOLE_0796 L recT protein COG3723 Cluster_137492 V1246534 L site-specific recombinase, phage integrase family 0ZJK4 Cluster_184704 V1246535 CLOSA_0730 V Hnh endonuclease COG1479 Cluster_433024 V1246536 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_151230 V1246538 S Membrane COG0628 Cluster_485054 V1246540 ACD map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I acyl-CoA dehydrogenase COG1960 Cluster_164505 V1246541 ACD map00071,map00280,map00281,map00362,map00410,map00640,map00650,map01100,map01110,map01120,map03320 I Acyl-CoA dehydrogenase, C-terminal domain COG1960 Cluster_766336 V1246542 P phosphonate ABC transporter substrate-binding protein COG3221 Cluster_200908 V1246543 HEMU map02010 P transporter, permease COG0609 Cluster_257750 V1246544 FTCD map00340,map00670,map01100 E Glutamate formiminotransferase COG3643 Cluster_528914 V1246545 CLOSA_1745 L transposase COG2963 Cluster_300869 V1246546 BCELL_1025 L Integrase COG2801 Cluster_104612 V1246548 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_152061 V1246549 map00500,map01100,map01110 G, M phosphorylase COG0438 Cluster_156972 V1246551 BAPKO_0207 P CBS domain protein COG1253 Cluster_365346 V1246552 RPE map00030,map00040,map00710,map01100,map01110,map01120,map01230 G ribulose-phosphate 3-epimerase COG0036 Cluster_267012 V1246553 RGPC map02010 V ABC-2 type transporter COG1682 Cluster_487345 V1246554 S thioesterase Superfamily protein 11IYE Cluster_460985 V1246555 S NA 0YR8M Cluster_832375 V1246557 RPSA map00900,map01100,map01110,map03010 J Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) COG0761 Cluster_718318 V1246558 ATPG map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) COG0224 Cluster_256468 V1246559 PERMEASE S permease COG0701 Cluster_785330 V1246561 map00190,map00680,map01100 C ATP synthase subunit C 11URT Cluster_324572 V1246564 K Phage antirepressor protein KilAC domain COG3646 Cluster_287366 V1246566 M RHS repeat-associated core domain protein COG3209 Cluster_249083 V1246567 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) COG0706 Cluster_669919 V1246568 ACYP map00620,map00627,map01120 C Acylphosphatase COG1254 Cluster_330520 V1246569 S beta-propeller domains of methanol dehydrogenase type COG1512 Cluster_106427 V1246571 DNAB L replication initiation and membrane attachment protein COG3611 Cluster_149598 V1246572 BL01373 L Integrase COG0582 Cluster_357126 V1246575 GLOB map00620 C Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) COG0491 Cluster_180348 V1246576 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_625468 V1246577 YGDL H uba thif-type nad fad binding protein COG1179 Cluster_534528 V1246578 T Positive regulator of sigma(E), RseC/MucC 0ZZM5 Cluster_232463 V1246579 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG0582 Cluster_338165 V1246581 RSME S Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) COG1385 Cluster_148837 V1246582 L integrase family 0XRS7 Cluster_232464 V1246583 YISR map02020 K Transcriptional regulator, ARAC family 11AZ4 Cluster_324573 V1246584 PPID O Peptidyl-prolyl cis-trans isomerase COG0760 Cluster_520480 V1246585 CYCMA_0607 S transposase 11H93 Cluster_546064 V1246586 S recombinase 11R6K Cluster_579636 V1246588 S Inherit from COG: Toxin-antitoxin system, toxin component, Fic family COG3943 Cluster_606936 V1246590 L UPF0102 protein COG0792 Cluster_398324 V1246591 RNHB map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0164 Cluster_777470 V1246592 YLQF K Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) COG1161 Cluster_557785 V1246594 SRLE map00051,map02060 G Pts system, glucitol sorbitol-specific COG3732 Cluster_115577 V1246595 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_264373 V1246596 SECF map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) COG0341 Cluster_805231 V1246600 map04122 S SirA family 0XX39 Cluster_298205 V1246601 S NA 1249W Cluster_560834 V1246602 S HIRAN domain 0XVUM Cluster_252775 V1246604 RNFB C electron transport complex, RnfABCDGE type, B subunit COG2878 Cluster_649006 V1246606 map03440 K Transcriptional regulator COG2865 Cluster_373622 V1246607 K Transcriptional regulator 1240D Cluster_285960 V1246609 MSMG map02010 P ABC transporter COG0395 Cluster_321427 V1246611 YUXL E Peptidase, S9A B C family, catalytic domain protein COG1506 Cluster_463104 V1246613 GLYQ map00970 J glycyl-tRNA synthetase, alpha subunit COG0752 Cluster_347369 V1246614 DGKA map00561,map00564,map01100,map04070 M Diacylglycerol kinase COG0818 Cluster_221994 V1246618 YQFA S UPF0365 protein COG4864 Cluster_142009 V1246619 MLEP map02020 C citrate carrier protein COG3493 Cluster_171167 V1246620 L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) COG0582 Cluster_844188 V1246621 S NA 122EK Cluster_189036 V1246622 ORFL L transposase COG2826 Cluster_247764 V1246623 S PspC domain COG1983 Cluster_309314 V1246624 M Nucleoside-diphosphate-sugar pyrophosphorylase 0ZRVF Cluster_460986 V1246625 RPLJ map03010 J ribosomal protein l10 COG0244 Cluster_492192 V1246626 PURE map00230,map01100,map01110 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) COG0041 Cluster_665631 V1246627 NTPG map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG1436 Cluster_512546 V1246628 map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG1155 Cluster_699282 V1246629 CBIN map02010 P Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) COG1930 Cluster_345778 V1246630 CBIM map02010 P Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) COG0310 Cluster_183000 V1246632 SP_1222 V restriction endonuclease 0ZVJ1 Cluster_728276 V1246634 S prevent-host-death family 0ZX42 Cluster_661420 V1246635 S Toxin-antitoxin system, toxin component, RelE family 123KX Cluster_408870 V1246636 S NA 0XX04 Cluster_403624 V1246637 S Protein of unknown function (DUF3160) 0XRJH Cluster_458931 V1246639 S NA 11G99 Cluster_546065 V1246640 K Transcriptional regulator 12DE3 Cluster_828622 V1246641 K acetyltransferase, (GNAT) family COG0454 Cluster_357127 V1246644 S DNA topoisomerase, type IA, zn finger domain protein 11J0S Cluster_200909 V1246646 YHAO L DNA repair exonuclease COG0420 Cluster_809258 V1246647 S Conserved domain protein COG4443 Cluster_465186 V1246648 S NA 120W9 Cluster_403625 V1246649 RECR map03440 L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) COG0353 Cluster_159555 V1246650 S NA 120WW Cluster_734785 V1246651 YAZA L domain protein COG2827 Cluster_517915 V1246653 S HTH_XRE 11ZMP Cluster_242556 V1246654 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_319946 V1246656 I CoA-substrate-specific enzyme activase COG1924 Cluster_520481 V1246657 S NA 1031E Cluster_534529 V1246659 M Outer membrane efflux protein 0XP27 Cluster_307896 V1246661 S NA 0YXMU Cluster_313775 V1246662 NAGD map00627,map01120 G had-superfamily hydrolase, subfamily iia COG0647 Cluster_537413 V1246663 ISCU C SUF system FeS assembly protein, NifU family COG0822 Cluster_285961 V1246664 YCSE S hydrolase COG0561 Cluster_377096 V1246665 S phage protein 11I5W Cluster_350604 V1246668 YDJZ S SNARE associated Golgi protein-related protein COG0398 Cluster_614266 V1246671 S NA 0XU8K Cluster_146527 V1246672 ASPB map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E aspartate COG0436 Cluster_267013 V1246673 L NA 0YZ4U Cluster_394823 V1246674 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_570089 V1246675 MRNC S Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) COG1939 Cluster_683303 V1246676 THYX map00240,map00340,map00350,map00624,map00670,map01120 F Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) COG1351 Cluster_485055 V1246677 ORFL L transposase COG2826 Cluster_425231 V1246678 map00340,map00350,map00624,map01120 Q O-Methyltransferase COG0500 Cluster_124109 V1246681 O Fn3-like domain (DUF1034) COG1404 Cluster_560835 V1246683 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_124110 V1246686 S NA COG5412 Cluster_224355 V1246687 S NA 0ZJGI Cluster_433025 V1246688 LDB1079 L integrase family COG0582 Cluster_128912 V1246689 MNTH P H( )-stimulated, divalent metal cation uptake system (By similarity) COG1914 Cluster_310760 V1246691 VICX map03013 S domain protein COG1235 Cluster_255234 V1246692 M Inherit from NOG: domain protein 18B9F@proNOG Cluster_256469 V1246693 C Binding Domain protein COG0348 Cluster_520482 V1246695 RPIB map00030,map00710,map01100,map01110,map01120,map01230 G isomerase B COG0698 Cluster_246509 V1246696 map02010 V ABC transporter COG1132 Cluster_295468 V1246697 F ATP cone domain COG1328 Cluster_213832 V1246698 S NA 0XTEF Cluster_156114 V1246701 CLCAR_1091 T Histidine kinase COG0642 Cluster_770057 V1246702 CARD K Transcriptional regulator (CarD family COG1329 Cluster_225527 V1246703 YACL S PilT protein domain protein COG4956 Cluster_182101 V1246704 E Aminotransferase class V COG0075 Cluster_273740 V1246705 CITE map00020,map01110,map02020 C Citrate lyase beta COG2301 Cluster_563821 V1246706 CITF map00020,map01110,map02020 C citrate lyase, alpha COG3051 Cluster_758600 V1246707 O Glutaredoxin 125U3 Cluster_434939 V1246709 NNRE S Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity) 124BP Cluster_377097 V1246710 RUBY C Rubrerythrin COG1592 Cluster_291326 V1246712 PPK map00190,map03018 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) COG0855 Cluster_127507 V1246713 PARC L DNA topoisomerase IV, subunit A COG0188 Cluster_216157 V1246714 METN map02010 P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COG1135 Cluster_384154 V1246715 S Uncharacterized BCR, YitT family COG1284 COG1284 Cluster_284516 V1246716 TRPA map00260,map00400,map01100,map01110,map01230 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) COG0159 Cluster_155305 V1246718 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_224356 V1246719 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_363604 V1246720 V Restriction modification system DNA (Specificity COG0732 Cluster_168549 V1246723 S relaxase mobilization nuclease domain protein 0XNXG Cluster_389460 V1246724 TRA L transposase COG2826 Cluster_683304 V1246725 RPSO map03010 J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) COG0184 Cluster_567007 V1246726 S Rhodanese-like domain 11QSF Cluster_230121 V1246727 HPRA map00260,map00630,map00680,map01100,map01110,map01120 C D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain COG1052 Cluster_758601 V1246728 RARA L recombination factor protein RarA COG2256 Cluster_813257 V1246729 S NA 0XSXN Cluster_618022 V1246730 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_718320 V1246731 RPSR map03010 J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) COG0238 Cluster_441018 V1246732 RPLI map03010 J Binds to the 23S rRNA (By similarity) COG0359 Cluster_781231 V1246734 ATPE map00190,map00195,map01100 C atp synthase COG0636 Cluster_344163 V1246735 ATPB map00190,map00195,map01100 C it plays a direct role in the translocation of protons across the membrane (By similarity) COG0356 Cluster_678760 V1246736 ATPF map00190,map00195,map01100 C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) COG0711 Cluster_315359 V1246737 LPXA map00540,map01100 M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) COG1043 Cluster_487346 V1246738 FTNA map00860 P ferritin COG1528 Cluster_160401 V1246740 MEGL map00260,map00270,map00450,map00920,map01100,map01110,map01230 E methionine gamma-lyase COG0626 Cluster_425232 V1246741 PYRE map00240,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_721626 V1246743 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_131908 V1246745 S (LipO)protein 0XSV5 Cluster_633012 V1246746 V Hnh endonuclease COG1403 Cluster_586073 V1246748 YACP J Tetracycline resistance protein COG3688 Cluster_336617 V1246749 RLMB map00340,map00350,map00624,map01120 J RNA methyltransferase TrmH family group 3 COG0566 Cluster_801037 V1246750 S Domain of unknown function (DUF3173) 125GK Cluster_377098 V1246752 QUEC map00790,map01100 S Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) COG0603 Cluster_224357 V1246753 GLK map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G glucokinase COG1940 Cluster_134289 V1246756 F ATP cone domain COG1328 Cluster_451046 V1246757 RAIA J ribosomal subunit Interface protein COG1544 Cluster_734786 V1246759 PURM map00230,map01100,map01110 F phosphoribosylaminoimidazole synthetase COG0150 Cluster_436998 V1246760 PURN map00230,map00670,map01100,map01110 F phosphoribosylglycinamide formyltransferase COG0299 Cluster_721627 V1246761 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_678761 V1246762 FTSX map02010 D Part of the ABC transporter FtsEX involved in cellular division (By similarity) COG2177 Cluster_135892 V1246763 LYSC map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Aspartokinase COG0527 Cluster_345779 V1246764 TEH_04440 map00052,map01100,map02060 G PTS system, galactitol-specific IIc component COG3775 Cluster_193503 V1246765 S NA 18A61@proNOG Cluster_741547 V1246767 S ABC transporter COG0488 Cluster_537414 V1246769 GAP map00010,map01100,map01110,map01120,map01230,map04066,map05010 G Glyceraldehyde-3-phosphate dehydrogenase COG0057 Cluster_136702 V1246770 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (alpha subunit) COG0587 Cluster_193504 V1246771 U TraG family COG3505 Cluster_269772 V1246773 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_269773 V1246774 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_441019 V1246775 SCPB K Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) COG1386 Cluster_770058 V1246780 PURK map00230,map01100,map01110 F phosphoribosylaminoimidazole carboxylase atpase subunit COG0026 Cluster_355434 V1246781 POTB map02010 P ABC transporter, permease COG1176 Cluster_150465 V1246782 DPAL map00260,map00290,map01100,map01110,map01230 E Diaminopropionate ammonia-lyase COG1171 Cluster_702351 V1246785 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_241185 V1246786 MRAY map00550,map01100 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) COG0472 Cluster_393002 V1246787 YPJC S YitT family COG1284 Cluster_199911 V1246788 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_148838 V1246789 PYRC map00240,map01100 F dihydroorotase COG0044 Cluster_299486 V1246794 M NA 0ZYVM Cluster_805232 V1246795 RUMA map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_537415 V1246796 L site-specific recombinase, phage integrase family 0ZF8H Cluster_363605 V1246797 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_353764 V1246799 L DNA repair protein radc COG2003 Cluster_389461 V1246801 K, T Peptidase S24-like COG1974 Cluster_573290 V1246802 S hydrolase 11G9J Cluster_382384 V1246804 RPSA map00900,map01100,map01110,map03010 J 30S ribosomal protein S1 COG0539 Cluster_728277 V1246805 K HTH_XRE 1018R Cluster_649008 V1246806 S Ser Thr phosphatase family protein 11JEF Cluster_724975 V1246807 V ABC transporter COG1136 Cluster_312277 V1246808 S NA 0YQH8 Cluster_504788 V1246810 RIMI S ribosomal-protein-alanine acetyltransferase COG0456 Cluster_502380 V1246811 RND J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) COG0349 Cluster_378883 V1246813 NTH map03410 L endonuclease III COG0177 Cluster_316879 V1246815 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_473651 V1246820 FOLT S Membrane 11R75 Cluster_391187 V1246822 K Transcriptional regulator 11JXM Cluster_603299 V1246823 ASP S Alkaline-shock protein COG1302 Cluster_144983 V1246824 NAGE map00010,map00500,map00520,map02060 G PTS System COG1264 Cluster_192618 V1246825 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_618023 V1246827 RUMAL_0153 L IS66 Orf2 family protein COG3436 Cluster_306590 V1246829 map00051 M glycosyl transferase group 1 COG0438 Cluster_884250 V1246830 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_201898 V1246831 PHOH T Phoh family COG1702 Cluster_405434 V1246832 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_777472 V1246833 YAAA S S4 domain protein YaaA COG2501 Cluster_549102 V1246834 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_657212 V1246835 KDSD M Arabinose 5-phosphate isomerase COG0794 Cluster_738134 V1246836 S YycH protein COG4853 Cluster_674309 V1246837 map02010 V ABC transporter COG1132 Cluster_360458 V1246838 HSDM V HsdM N-terminal domain COG0286 Cluster_443021 V1246839 V Type I restriction-modification system R subunit COG4096 Cluster_146529 V1246840 NIRJ L Pyrroloquinoline quinone biosynthesis protein E COG0535 Cluster_303696 V1246842 PRSA O Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) COG0760 Cluster_283143 V1246843 PGN_0971 L Transposase, is4 family COG3039 Cluster_333584 V1246844 CAS5E L crispr-associated protein 11JEJ Cluster_357128 V1246846 S NA 11J85 Cluster_687730 V1246847 O Peptidyl-prolyl cis-trans isomerase COG0760 Cluster_629158 V1246848 G Inherit from bactNOG: transporter COG2211 Cluster_579637 V1246849 K Transcriptional regulator COG3682 Cluster_223170 V1246851 INSH5 L Transposase COG3039 Cluster_880097 V1246852 PLSY map00561,map00564,map01100 S Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) COG0344 Cluster_216158 V1246853 M Auxiliary transport protein, membrane fusion protein COG0845 Cluster_365347 V1246855 S NA 0Y50Z Cluster_196165 V1246857 BH0416 L Transposase COG3464 Cluster_148839 V1246858 BH0416 L Transposase COG3464 Cluster_610586 V1246859 RPSP map03010 J 30s ribosomal protein S16 COG0228 Cluster_494674 V1246860 YBEY map00240,map00983,map01100 F Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) COG0319 Cluster_327628 V1246862 TRMD map00900,map01100,map01110 J Specifically methylates guanosine-37 in various tRNAs (By similarity) COG0336 Cluster_570090 V1246863 NADD map00230,map00760,map01100,map05340 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) COG1057 Cluster_171988 V1246864 BSEL_0404 L RNA-directed DNA polymerase (Reverse transcriptase) COG3344 Cluster_265705 V1246868 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_391188 V1246869 map00051,map00564,map01100 I PAP2 Family COG0671 Cluster_275098 V1246870 CLCAR_3340 S NA 11RSA Cluster_515246 V1246871 S DNA-binding protein 0YGF9 Cluster_871956 V1246872 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_629159 V1246873 S Protein of unknown function (DUF464) 0XV7X Cluster_353765 V1246876 YCBB map00051 M Glycosyl transferase, family 2 COG0463 Cluster_309315 V1246878 RPSB map03010 J 30S ribosomal protein S2 COG0052 Cluster_805234 V1246879 TRER K GntR family transcriptional regulator COG2188 Cluster_344164 V1246880 CAS5D L CRISPR-associated protein 0XQ9Q Cluster_649009 V1246881 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_502381 V1246882 USPA T Universal stress protein COG0589 Cluster_339588 V1246883 S NA 0ZCBM Cluster_520483 V1246884 MRAZ S Cell division protein mraZ COG2001 Cluster_152899 V1246885 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_191678 V1246887 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_202944 V1246891 FBPC map02010 E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COG3842 Cluster_200910 V1246892 RFBB map00521,map00523,map01055,map01100,map01110 M dtdp-glucose 4,6-dehydratase COG1088 Cluster_335088 V1246894 NPDA map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_275099 V1246895 NUSA K Transcription elongation factor NusA COG0195 Cluster_531732 V1246897 NTPC map00190,map00680,map01100 C ATP synthase subunit C COG1527 Cluster_441020 V1246898 C Inherit from NOG: Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) 11U31 Cluster_427149 V1246901 EFP J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) COG0231 Cluster_820854 V1246902 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_718321 V1246903 HOKE S Hok Gef family protein 185YR@proNOG Cluster_407102 V1246907 YQEK map00760,map01100 H Metal Dependent Phosphohydrolase COG1713 Cluster_183824 V1246908 map00360 E amidohydrolase COG1473 Cluster_755085 V1246911 TATA map03060,map03070 U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) 0XUF0 Cluster_560836 V1246912 COBW S CobW P47K family protein COG0523 Cluster_176153 V1246915 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_193505 V1246916 NEUC map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_159556 V1246917 D Maf-like protein COG0424 Cluster_324574 V1246918 SP_1232 S Membrane COG4684 Cluster_159557 V1246919 T Leucine-rich repeAt COG4886 Cluster_225528 V1246920 S Endonuclease Exonuclease phosphatase 0XPGG Cluster_159558 V1246921 BAS2305 G Major Facilitator superfamily COG0477 Cluster_210500 V1246922 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_256470 V1246923 MNTP P Probably functions as a manganese efflux pump (By similarity) COG1971 Cluster_160402 V1246924 M Inherit from COG: YD repeat protein COG3209 Cluster_338167 V1246925 RECO map03440 L Involved in DNA repair and RecF pathway recombination (By similarity) 0XR7P Cluster_160403 V1246927 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_497184 V1246928 SIGM K RNA Polymerase 123AD Cluster_431026 V1246930 SP_1232 S Membrane COG4684 Cluster_161223 V1246931 U TraG family COG3505 Cluster_341050 V1246934 HSDM V type I restriction-modification system COG0286 Cluster_509975 V1246938 S Protein of unknown function (DUF3290) 0Y3NW Cluster_766337 V1246939 K Transcriptional regulator, TetR family 11IM0 Cluster_699283 V1246940 L DNA (cytosine-5-)-methyltransferase COG2189 Cluster_269774 V1246941 V Type III restriction enzyme, res subunit 0Y2F5 Cluster_456948 V1246943 MENA map00130,map01100,map01110 H 1,4-dihydroxy-2-naphthoate octaprenyltransferase COG1575 Cluster_344165 V1246944 RNC map03008,map05205 K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) COG0571 Cluster_169479 V1246945 CKL_2970 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_412536 V1246947 RPSD map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) COG0522 Cluster_665632 V1246948 MTAD F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) COG0402 Cluster_238633 V1246949 COMGA U Competence protein COG2804 Cluster_721628 V1246950 G Major Facilitator 0XPHU Cluster_299487 V1246951 PPIB O PPIases accelerate the folding of proteins COG0652 Cluster_801038 V1246953 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_249084 V1246954 YHCC S Radical SAM Protein COG1242 Cluster_458932 V1246956 S HutD COG3758 Cluster_497185 V1246957 S NA 11GDW Cluster_403626 V1246958 S NA 12CNX Cluster_669921 V1246959 K Transcriptional regulator 121R0 Cluster_377099 V1246960 NTH map03410 L endonuclease III COG0177 Cluster_166167 V1246961 HSDM V type I restriction-modification system COG0732 Cluster_504789 V1246962 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_310762 V1246963 S NA 0ZB7H Cluster_305199 V1246964 S SusD family 0YMB2 Cluster_220835 V1246965 RBSB map02010,map02030 G Ribose ABC transporter COG1879 Cluster_414414 V1246966 SP_0885 S domain protein 0XRFP Cluster_307897 V1246968 K Transcriptional regulator COG1737 Cluster_378884 V1246970 RBR C Rubrerythrin COG1592 Cluster_781232 V1246973 V Mate efflux family protein COG0534 Cluster_247765 V1246974 HSLO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) COG1281 Cluster_186498 V1246975 LMRA map02010 V Abc transporter COG1132 Cluster_327629 V1246976 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG0469 Cluster_254025 V1246977 I alpha/beta hydrolase fold COG0657 Cluster_170348 V1246978 COMEC S DNA internalization-related competence protein ComEC Rec2 COG2333 Cluster_339589 V1246980 FABG map00061,map00780,map01040,map01100 S reductase 0XNW1 Cluster_370365 V1246981 AVTA map00300,map01100,map01210,map01230 E, K Aminotransferase, class I II COG1167 Cluster_699284 V1246982 ETFA map00910 C Electron transfer flavoprotein COG2025 Cluster_515247 V1246983 T Two component transcriptional regulator (Winged helix family COG0745 Cluster_499850 V1246984 O peptidase, S8 COG1404 Cluster_512547 V1246985 SP_1863 K Transcriptional regulator, MarR family COG1846 Cluster_451047 V1246987 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_665633 V1246990 RPLU map03010 J This protein binds to 23S rRNA in the presence of protein L20 (By similarity) COG0261 Cluster_171989 V1246991 PPSA map00620,map00680,map00720,map01100,map01120 G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) COG0574 Cluster_621666 V1246992 BTA C, O transport accessory protein COG0526 Cluster_171990 V1246993 THA_2007 L Transposase COG2801 Cluster_171991 V1246994 COMEC S Competence protein COG2333 Cluster_184705 V1246995 BMPA S basic membrane COG1744 Cluster_329115 V1246996 CPN_0573 K transcriptional regulatory protein COG0217 Cluster_809264 V1246997 NADE map00760,map01100 H nh(3)-dependent nad( ) synthetase COG0171 Cluster_172904 V1246998 map02010 V ABC transporter transmembrane region COG1132 Cluster_355435 V1246999 CITE map00020,map01110,map02020 C Citrate lyase subunit beta COG2301 Cluster_509976 V1247000 CITF map00020,map01110,map02020 C citrate lyase, alpha COG3051 Cluster_485057 V1247001 S NA 0YF67 Cluster_276426 V1247002 S Protein of unknown function (Porph_ging) 124PH Cluster_436999 V1247003 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_489694 V1247004 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_596219 V1247005 PANB map00770,map01100,map01110 H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) COG0413 Cluster_316880 V1247006 H NADP oxidoreductase, coenzyme f420-dependent COG5495 Cluster_665634 V1247010 TRXA O Thioredoxin COG0526 Cluster_217356 V1247011 MCRC V restriction COG4268 Cluster_661421 V1247013 S domain protein 0XPXI Cluster_840172 V1247014 YEEN K transcriptional regulatory protein COG0217 Cluster_174543 V1247015 SECD map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) COG0342 Cluster_262991 V1247016 DAT map00280,map00290,map00310,map00330,map00360,map00472,map00473,map00770,map00790,map01100,map01110,map01210,map01230 E Aminotransferase COG0115 Cluster_191679 V1247017 PEPQ map00310,map00780,map01100 E peptidase M24 COG0006 Cluster_216159 V1247018 YQFA S UPF0365 protein COG4864 Cluster_458933 V1247019 IDSA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_741549 V1247020 VEG S Veg protein COG4466 Cluster_441021 V1247021 FAT map00061,map01100 I Acyl-ACP thioesterase COG3884 Cluster_300870 V1247023 TRPC map00400,map01100,map01110,map01230 E Indole-3-glycerol phosphate synthase COG0134 Cluster_625470 V1247024 YTQB map00340,map00350,map00624,map01120 Q rRNA Methylase COG0500 Cluster_184706 V1247028 V ABC transporter, permease COG0577 Cluster_296815 V1247029 S Phage NTP-binding protein 0ZW6P Cluster_471559 V1247030 L Inherit from COG: transposase COG5444 Cluster_649010 V1247031 CBPA O DnaJ domain protein COG2214 Cluster_377100 V1247032 S Membrane COG3601 Cluster_755086 V1247033 CORC P CBS domain protein COG1253 Cluster_177809 V1247034 HELD map03420,map03430 L helicase COG3973 Cluster_178649 V1247037 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_179517 V1247038 U TraG family COG3505 Cluster_573292 V1247039 MRNC S Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) COG1939 Cluster_321428 V1247040 PSTB1 map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_178650 V1247041 U, W Pfam:YadA COG5295 Cluster_531733 V1247043 S NA 11TBU Cluster_520484 V1247044 SARZ K Transcriptional regulator 11TPH Cluster_179518 V1247045 L helicase COG4646 Cluster_456949 V1247047 LEPB map03060 U Signal peptidase i COG0681 Cluster_401842 V1247048 WECC map00051,map00363,map00520,map00591,map00625,map00650,map01100,map01120 M Dehydrogenase COG0677 Cluster_625471 V1247049 MAZF T Toxic component of a toxin-antitoxin (TA) module (By similarity) COG2337 Cluster_913349 V1247050 SP_0239 S UPF0210 protein COG2848 Cluster_449081 V1247051 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_419770 V1247052 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_433026 V1247053 PDUO map00860,map01100 S adenosyltransferase COG2096 Cluster_180349 V1247054 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_543117 V1247055 S NA 12ATY Cluster_618024 V1247056 NUOA map00190,map00910,map01100 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain COG0838 Cluster_824825 V1247057 S NA 12666 Cluster_212718 V1247058 KBL map00260,map00780,map01100 E 2-amino-3-ketobutyrate coenzyme A ligase COG0156 Cluster_194437 V1247059 map00071,map00280,map00281,map00650,map01100,map01110 I acyl-Coa dehydrogenase COG1960 Cluster_391189 V1247060 GLOB map00620 Q domain protein COG0491 Cluster_758602 V1247061 DTD J Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) COG1490 Cluster_378885 V1247063 KTRA P domain protein COG0569 Cluster_183001 V1247064 T ATPase histidine kinase DNA gyrase B HSP90 domain protein 0XNMH Cluster_210501 V1247065 YABE M domain protein COG3584 Cluster_296816 V1247068 S NIF3 (NGG1p interacting factor 3) COG0327 Cluster_196984 V1247071 S Bacterial SH3 domain 0ZPAA Cluster_475817 V1247072 S Protein of unknown function (DUF3408) 0ZA41 Cluster_734787 V1247074 S NA 0ZHT2 Cluster_603300 V1247076 N repeat protein 11QCF Cluster_531734 V1247077 YFIC map02010 V ABC transporter COG1132 Cluster_731572 V1247078 S Conserved domain protein COG4443 Cluster_184707 V1247080 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_515248 V1247081 NFED O, U Membrane protein implicated in regulation of membrane protease activity COG1585 Cluster_412537 V1247082 BL03733 map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_469396 V1247085 S NA 11PBT Cluster_475818 V1247086 COAD map00770,map01100 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) COG0669 Cluster_669922 V1247088 LSA_07090 L Transposase COG2963 Cluster_497186 V1247090 RPSG map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) COG0049 Cluster_606937 V1247091 CCPA K Transcriptional regulator COG1609 Cluster_347370 V1247093 S NA 0Y3II Cluster_358796 V1247094 ACDA map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I Acyl-coa dehydrogenase COG2025 Cluster_579638 V1247095 FPRA C domain protein COG0426 Cluster_859681 V1247096 PYRI map00240,map00250,map01100 F Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) COG1781 Cluster_243907 V1247097 PYRB map00240,map00250,map01100 F aspartate transcarbamylase COG0540 Cluster_557787 V1247099 EXPZ S Abc transporter COG0488 Cluster_649012 V1247100 K Transcriptional regulator 11VTG Cluster_473652 V1247101 TRXA_2 O Thioredoxin COG0526 Cluster_187336 V1247102 THRS map00020,map00300,map00630,map00720,map01100,map01110,map01120,map01210,map01230 C Aconitate hydratase COG1048 Cluster_188197 V1247103 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_268430 V1247105 RNFC C Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) COG4656 Cluster_283144 V1247106 LYX map00040,map00053,map01100 G L-xylulose kinase COG1070 Cluster_285962 V1247107 DEGV S degv family COG1307 Cluster_196166 V1247108 BH0416 L Transposase COG3464 Cluster_657213 V1247109 SECD map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) COG0342 Cluster_191680 V1247110 T Histidine kinase COG0642 Cluster_280399 V1247111 map02010 P (ABC) transporter COG1121 Cluster_540214 V1247112 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_267014 V1247113 M Cell wall binding repeat 2-containing protein COG2247 Cluster_189037 V1247114 S NA 101UU Cluster_189903 V1247115 S transporter gate domain protein 0XRV8 Cluster_230122 V1247116 HYDA map00240,map00410,map00770,map00983,map01100 F dihydropyrimidinase (EC 3.5.2.2) COG0044 Cluster_728279 V1247118 TAGO M Glycosyl transferase, family 4 COG0472 Cluster_294060 V1247119 WECB map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_360459 V1247120 L DNA alkylation repair enzyme COG4912 Cluster_303697 V1247122 E 2-hydroxyglutaryl-CoA dehydratase COG1775 Cluster_724977 V1247124 L DNA uptake protein and related DNA-binding COG1555 Cluster_405435 V1247125 XYLG S ABC transporter COG3845 Cluster_200911 V1247126 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_191681 V1247127 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_403627 V1247128 S NA 11SZV Cluster_724978 V1247130 BL05010 S ribosomal protein L14e 0XUZY Cluster_781233 V1247131 INFA J however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) COG0361 Cluster_892278 V1247132 S ATP GTP-binding protein 0Y0B5 Cluster_832378 V1247133 S Tetratricopeptide repeat protein 124W9 Cluster_711685 V1247134 FTSX map02010 D Part of the ABC transporter FtsEX involved in cellular division (By similarity) COG2177 Cluster_414415 V1247139 RUVA map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) COG0632 Cluster_330521 V1247140 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_606938 V1247141 V Type I site-specific deoxyribonuclease COG0610 Cluster_567008 V1247147 VANZ V VanZ-like protein COG4767 Cluster_368667 V1247148 H IA, variant 3 COG0637 Cluster_195314 V1247149 DPNA L helicase COG4646 Cluster_543118 V1247151 YJEE S protein family UPF0079, ATPase COG0802 Cluster_284517 V1247153 CASA L crispr-associated protein 0XPA1 Cluster_307898 V1247154 S NA 11YT1 Cluster_305200 V1247155 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_249085 V1247159 PORA map00020,map00720,map01100,map01120 C Pyruvate flavodoxin ferredoxin oxidoreductase domain protein COG1014 Cluster_618025 V1247160 S domain-containing protein 11PBU Cluster_526147 V1247161 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_549103 V1247162 map00362,map01100,map01120 S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) 11M0H Cluster_197924 V1247163 CSHA map03018 L ATP-dependent RNA helicase COG0513 Cluster_221995 V1247167 TEX K domain protein COG2183 Cluster_309316 V1247168 GRAS map02020 T Histidine kinase COG0642 Cluster_523238 V1247170 S NA 0XTEF Cluster_629160 V1247171 YFCE S Phosphodiesterase COG0622 Cluster_198912 V1247174 map02010 P ABC superfamily ATP binding cassette transporter ABC protein COG1122 Cluster_416188 V1247177 S Membrane COG1434 Cluster_279088 V1247178 PEPN map00480,map01100 E aminopeptidase N COG0308 Cluster_445012 V1247179 FOLA map00670,map00790,map01100 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) COG0262 Cluster_625472 V1247180 S Membrane 0ZWJJ Cluster_250335 V1247182 BH0416 L Transposase COG3464 Cluster_265706 V1247185 METP P transporter COG0733 Cluster_687731 V1247187 S NA 124TW Cluster_702352 V1247188 RPSQ map03010 J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal COG0186 Cluster_699285 V1247189 BL00143 L Transposase 122W1 Cluster_375329 V1247190 E asp glu hydantoin 11SZY Cluster_264374 V1247191 FBA map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01230 G Aldolase COG0191 Cluster_458934 V1247192 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_207252 V1247194 map02020 S Membrane COG3333 Cluster_200912 V1247197 M NA 0ZY8Y Cluster_458935 V1247198 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_724979 V1247199 SPXA K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) COG1393 Cluster_467282 V1247200 FLAR F topology modulation protein COG0563 Cluster_262992 V1247201 S ATP GTP-binding protein 0Y0B5 Cluster_868000 V1247202 S conjugative transposon membrane protein 0XQIJ Cluster_443022 V1247204 T regulatoR COG0745 Cluster_531735 V1247205 map00020,map00300,map00630,map00720,map01100,map01110,map01120,map01210,map01230 C aconitate hydratase COG1048 Cluster_203991 V1247206 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_509977 V1247207 S NA 0YJQ6 Cluster_502383 V1247208 CYDB map00190,map01100,map02020 C cytochrome D ubiquinol oxidase subunit II COG1294 Cluster_215024 V1247211 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_618026 V1247214 M NA 0ZYVM Cluster_777473 V1247215 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG2812 Cluster_348979 V1247216 YUGP S zinc metallopeptidase COG2738 Cluster_224358 V1247217 AGCS E amino acid carrier protein COG1115 Cluster_387751 V1247222 UDK map00240,map00983,map01100 F uridine monophosphokinase COG0572 Cluster_809265 V1247223 S NA 0ZNJG Cluster_731573 V1247225 CYSE map00270,map00920,map01100,map01120,map01230 E serine acetyltransferase COG1045 Cluster_319947 V1247226 CYSK map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_216160 V1247227 YXCA I coA-substrate-specific enzyme activase COG3581 Cluster_210502 V1247230 ROCB E peptidase, M20 COG4187 Cluster_592745 V1247231 PROA map00330,map01100,map01230 E Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) COG0014 Cluster_582880 V1247233 ISPE map00900,map01100,map01110 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COG1947 Cluster_208380 V1247234 S NA 11NI8 Cluster_313776 V1247236 GUFA P Mediates zinc uptake. May also transport other divalent cations (By similarity) COG0428 Cluster_208381 V1247237 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_272412 V1247239 S NA 11KGV Cluster_223171 V1247240 MURG map00550,map01100,map04112 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) COG0707 Cluster_621671 V1247244 FECD map02010 P abc transporter COG0609 Cluster_335089 V1247247 NAGB map00520,map01100,map01110 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COG0363 Cluster_534530 V1247248 G extracellular solute-binding protein family 1 0XQSR Cluster_211626 V1247249 OCAR_6158 L Terminase, large subunit COG4626 Cluster_405436 V1247250 M outer membrane chaperone Skp (OmpH) 11PTW Cluster_408871 V1247251 map00330,map00760,map01100,map01120 Q isochorismatase COG1335 Cluster_683307 V1247252 T cyclic nucleotide-binding domain protein COG0664 Cluster_210503 V1247253 map02010 E Extracellular solute-binding protein, family 5 COG0747 Cluster_210504 V1247254 S NA 0Z34Z Cluster_451048 V1247258 FAHA Q 5-carboxymethyl-2-hydroxymuconate delta-isomerase (EC 5.3.3.10) COG0179 Cluster_211627 V1247259 GLGB map00500,map01100,map01110 G 1,4-alpha-glucan branching enzyme COG0296 Cluster_313777 V1247260 UDP map00240,map00983,map01100 F Uridine phosphorylase COG2820 Cluster_269775 V1247262 RPIR K transcriptional regulator COG1737 Cluster_599726 V1247263 map02020,map03070 U Prokaryotic N-terminal methylation motif 0ZR0Y Cluster_232465 V1247265 GPPA map00230 F, P ppx gppa phosphatase COG0248 Cluster_586074 V1247266 CUTA S divalent ion tolerance protein COG3323 Cluster_603301 V1247267 S membrane 11V90 Cluster_621672 V1247268 map02020 T response regulator COG2197 Cluster_625473 V1247269 SURB S G5 domain protein 0ZVV3 Cluster_213833 V1247270 M NA 0YHI1 Cluster_215025 V1247271 S NA 0ZTYV Cluster_460988 V1247274 S Nitroreductase 11NZA Cluster_329116 V1247277 COBS map00860,map01100 H Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) COG0368 Cluster_596220 V1247279 S NA 11U8H Cluster_268431 V1247280 GLGB map00500,map01100,map01110 G 1,4-alpha-glucan branching enzyme COG0296 Cluster_216161 V1247281 ADDA L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation COG1074 Cluster_465187 V1247283 TRML map04122 J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) COG0219 Cluster_216162 V1247284 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_218491 V1247285 map02010 V Abc transporter COG1132 Cluster_281734 V1247286 YHGE S domain protein COG1511 Cluster_398325 V1247288 S Cell-surface protein 0YXKT Cluster_499851 V1247289 GUAD map00230,map01100 F, J deaminase COG0590 Cluster_478015 V1247292 S Rubrerythrin 0ZY0X Cluster_705449 V1247293 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_218493 V1247294 map00564 S NA 11NI7 Cluster_277733 V1247296 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_249086 V1247298 S NA 11F7I Cluster_766339 V1247299 YLQC S UPF0109 protein COG1837 Cluster_219645 V1247300 M NA 11FBZ Cluster_220837 V1247301 U, W Pfam:YadA COG5295 Cluster_284518 V1247303 S Abortive infection protein AbiGII 0XQHH Cluster_507369 V1247304 S NA 0YNY2 Cluster_319948 V1247305 DHAK map00561,map00680,map01100,map01120,map04622 G Dihydroxyacetone kinase COG2376 Cluster_456950 V1247306 S Filamentation induced by cAMP protein fic 11MJJ Cluster_220838 V1247308 L helicase COG4646 Cluster_695995 V1247309 RPSH map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) COG0096 Cluster_751615 V1247310 DAPB map00300,map01100,map01110,map01120,map01230 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) COG0289 Cluster_618027 V1247311 K Transcriptional regulator COG1695 Cluster_582881 V1247313 RRGB M Lpxtg-motif cell wall anchor domain protein 0XSEP Cluster_485058 V1247315 V type i restriction COG0732 Cluster_260386 V1247316 GLTC K transcriptional regulator COG0583 Cluster_718322 V1247317 RPSI map03010 J 30S ribosomal protein S9 COG0103 Cluster_543119 V1247318 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E brancheD-chain amino acid aminotransferase COG0115 Cluster_687732 V1247319 S NA 0YRD4 Cluster_844192 V1247321 S Protein of unknown function (DUF541) 0YM36 Cluster_355436 V1247322 GDH map00250,map00330,map00910,map01100 E Glutamate dehydrogenase COG0334 Cluster_610588 V1247323 P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) COG0168 Cluster_661422 V1247328 RPSJ map03010 J Involved in the binding of tRNA to the ribosomes (By similarity) COG0051 Cluster_766340 V1247329 RPLC map03010 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 Cluster_734790 V1247330 map02010 P ABC superfamily ATP binding cassette transporter COG1122 Cluster_224359 V1247331 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_465188 V1247332 MALE map02010 G (ABC) transporter COG2182 Cluster_360460 V1247333 S s-layer domain-containing protein 11ZJU Cluster_471560 V1247335 ARGS map00970 J Arginyl-tRNA synthetase COG0018 Cluster_225529 V1247337 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_225530 V1247338 COPA P p-type ATPase COG2217 Cluster_226648 V1247341 PLDB map00564 I alpha beta COG2267 Cluster_226649 V1247342 V Mate efflux family protein COG0534 Cluster_251554 V1247344 S NA 0ZX1V Cluster_517917 V1247345 K MarR family Transcriptional regulator COG1846 Cluster_292676 V1247346 YQFL S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) COG1806 Cluster_375330 V1247347 G Major Facilitator COG2814 Cluster_738135 V1247349 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_357129 V1247350 map02010 P Cobalt transport protein COG0619 Cluster_307899 V1247351 S Copper amine oxidase N-terminal domain 12921 Cluster_557788 V1247353 MDSC S Aminoglycoside phosphotransferase 0XP56 Cluster_419772 V1247354 GALE map00052,map00520,map01100,map01110 M udp-glucose 4-epimerase COG1087 Cluster_228953 V1247358 DDL map00473,map00520,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_708539 V1247359 YLXP S Protein of unknown function (DUF503) COG1550 Cluster_586075 V1247361 NUOA map00190,map00910,map01100 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain COG0838 Cluster_318460 V1247362 C Binding Domain protein 11NY9 Cluster_705450 V1247363 ISPA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_285963 V1247364 XTH map03410 L Exodeoxyribonuclease III COG0708 Cluster_653078 V1247365 INT L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) COG0582 Cluster_230123 V1247366 S NA 0YCCW Cluster_393003 V1247368 S NA 11Y61 Cluster_302250 V1247369 GLTA map00250,map00910,map01100,map01110,map01120,map01230 E Glutamate synthase COG0543 Cluster_353766 V1247373 AZLC E amino acid COG1296 Cluster_232466 V1247374 G domain protein 11V8D Cluster_265707 V1247375 map02010 P ABC transporter COG0395 Cluster_232467 V1247376 CBPA O DnaJ domain protein COG2214 Cluster_233725 V1247378 FRVB G PTS System COG1445 Cluster_447063 V1247380 RIMM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) COG0806 Cluster_350605 V1247383 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_465190 V1247384 TNP L transposase COG1943 Cluster_233726 V1247385 M domain protein COG4932 Cluster_582882 V1247388 S Inherit from COG: Alpha beta hydrolase COG0596 Cluster_262993 V1247391 DGT map00230 F deoxyguanosinetriphosphate triphosphohydrolase-like protein COG0232 Cluster_758605 V1247392 RPME map03010 J 50s ribosomal protein l31 COG0254 Cluster_272413 V1247393 BL00144 L Transposase COG2801 Cluster_718323 V1247395 S NA 1212G Cluster_423424 V1247397 M Inherit from COG: YD repeat protein COG3209 Cluster_236119 V1247398 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_292677 V1247401 D CobQ/CobB/MinD/ParA nucleotide binding domain COG1192 Cluster_451049 V1247402 map00190,map00910,map01100 C NADH dehydrogenase (Ubiquinone), 24 kDa subunit COG1905 Cluster_357130 V1247403 IDSA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_347371 V1247404 S NA 0YPHQ Cluster_336618 V1247406 YBIT S ABC transporter COG0488 Cluster_437000 V1247407 MDMC map00340,map00350,map00360,map00624,map00940,map00941,map00945,map01100,map01110,map01120 S O-methyltransferase COG4122 Cluster_239904 V1247411 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_549104 V1247412 L NA 0YJFA Cluster_239905 V1247413 S NA 12D1P Cluster_606939 V1247414 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_836271 V1247415 S repeat protein 11IAG Cluster_517918 V1247416 T Inherit from COG: Phoh family COG1702 Cluster_576523 V1247417 POTA map02010 E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COG3842 Cluster_239906 V1247418 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_239907 V1247419 YLBM S UPF0348 protein COG1323 Cluster_724980 V1247420 YLZA S UPF0296 protein COG2052 Cluster_586076 V1247421 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_312278 V1247422 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E brancheD-chain amino acid aminotransferase COG0115 Cluster_241187 V1247424 FLIC map02020,map02040,map04626,map05132,map05134 N Flagellin COG1344 Cluster_242557 V1247425 G alpha amylase, catalytic COG0366 Cluster_363606 V1247426 MGTC S MgtC SapB transporter COG1285 Cluster_393004 V1247427 S Cytidylate kinase 0XP28 Cluster_307900 V1247428 METK S methionine adenosyltransferase 0YTXD Cluster_242558 V1247430 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_721629 V1247436 CMK map00240,map00410,map00770,map01100,map01110 F Cytidine monophosphate kinase COG0283 Cluster_279089 V1247437 CPAP_0279 L Transposase COG2801 Cluster_377101 V1247438 S Pfam:DUF901 11XWA Cluster_649014 V1247440 COMEA L Competence protein COG1555 Cluster_813260 V1247442 RELA2 S RelA SpoT domain-containing protein COG2357 Cluster_322992 V1247445 V Mate efflux family protein COG0534 Cluster_254027 V1247446 TELA P Resistance protein COG3853 Cluster_326072 V1247447 YOCR P transporter COG0733 Cluster_292678 V1247449 CYNR K Transcriptional regulator 0ZWMP Cluster_416190 V1247450 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_405437 V1247451 SODA map04146,map05016 P Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) COG0605 Cluster_324575 V1247452 S NA 12BX3 Cluster_625474 V1247453 TRXB map00240,map00450 O thioredoxin reductase COG0492 Cluster_417993 V1247454 S Arylsulfotransferase (ASST) 0XPAA Cluster_526148 V1247455 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_276427 V1247456 map02010 P ABC transporter COG1122 Cluster_766341 V1247457 JAG S Single-stranded nucleic acid binding R3H domain-containing protein COG1847 Cluster_284519 V1247461 UMUC L ImpB MucB SamB family protein COG0389 Cluster_520485 V1247462 WBYK M Glycosyl transferases group 1 COG0438 Cluster_247766 V1247463 NHAC-1 map00680 C Na H antiporter COG1757 Cluster_247767 V1247464 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_687733 V1247466 RPMA map03010 J 50S ribosomal protein l27 COG0211 Cluster_321429 V1247467 ISPG map00900,map01100,map01110 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) COG0821 Cluster_336619 V1247469 TETV G major facilitator superfamily MFS_1 0ZTBD Cluster_385930 V1247470 S NA 1224P Cluster_687734 V1247471 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_336620 V1247472 S ErfK YbiS YcfS YnhG COG1376 Cluster_614269 V1247476 map00051 M glycosyltransferase group 2 family protein COG0463 Cluster_433028 V1247477 AMRA M polysaccharide biosynthesis protein COG2244 Cluster_287367 V1247478 SP_0899 S Membrane Associated 114SZ Cluster_290008 V1247480 DUSB J Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_657214 V1247481 SLGD_00062 S membrAne 11F2H Cluster_534531 V1247482 DPRA L DNA protecting protein DprA COG0758 Cluster_687735 V1247483 VNCS T Histidine kinase COG0642 Cluster_250336 V1247484 map00510,map01100 M GtrA-like protein COG0463 Cluster_318461 V1247485 L DNA methylase n-4 n-6 domain protein COG0863 Cluster_285964 V1247487 K transcriptional regulator, IclR family COG1414 Cluster_252776 V1247488 BTUB P Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) COG4206 Cluster_295469 V1247489 BCELL_1025 L Integrase COG2801 Cluster_348980 V1247490 RPRY map02020 T response regulator COG0745 Cluster_451050 V1247493 YLBN S metal-binding protein COG1399 Cluster_333585 V1247494 S NA 11FTC Cluster_625475 V1247499 RSFS S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) COG0799 Cluster_770059 V1247500 YYZM S protein, conserved in bacteria COG4481 Cluster_396601 V1247501 M protein (LPxTG motif) COG4932 Cluster_629161 V1247503 RPLQ map03010 J 50S ribosomal protein l17 COG0203 Cluster_549105 V1247505 Y1855 P asch domain protein COG4405 Cluster_480419 V1247506 J gCN5-related N-acetyltransferase COG1670 Cluster_781234 V1247509 RPSS map03010 J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) COG0185 Cluster_789353 V1247510 RSMG M Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) COG0357 Cluster_708541 V1247511 SUA J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0009 Cluster_347372 V1247513 RLMB map00340,map00350,map00624,map01120 J RNA methyltransferase TrmH family group 3 COG0566 Cluster_256471 V1247514 S P-loop domain protein 0XQDB Cluster_657215 V1247516 map00061,map00072,map00650,map00780,map01040,map01100 I, Q short-chain dehydrogenase reductase COG1028 Cluster_669923 V1247517 LCTO map00620,map01100 C Dehydrogenase COG1304 Cluster_439040 V1247518 S NA COG5412 Cluster_312279 V1247519 S NA 11VT6 Cluster_257751 V1247520 GLNN map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG3968 Cluster_355437 V1247522 FTSE map02010 D Cell division ATP-binding protein ftsE COG2884 Cluster_358797 V1247523 VICR map02020 T response regulator COG0745 Cluster_378887 V1247525 S NA 11ISF Cluster_363607 V1247526 S TIM-barrel fold 11FGY Cluster_260387 V1247527 S NA 1298D Cluster_724982 V1247528 AROH map00400,map01100,map01110,map01230 E Chorismate mutase COG1605 Cluster_419773 V1247530 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_260388 V1247531 PORU S NA 0XPE4 Cluster_625476 V1247533 RPLS map03010 J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) COG0335 Cluster_499852 V1247535 TRML map04122 J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) COG0219 Cluster_657216 V1247536 P Na Pi-cotransporter COG1283 Cluster_439041 V1247540 AROK map00400,map01100,map01110,map01230 E Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) COG0703 Cluster_797103 V1247541 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_260389 V1247542 FDHC map00630,map00680,map01100,map01120 C formate dehydrogenase COG2864 Cluster_721630 V1247544 S B3 4 domain protein COG3382 Cluster_683308 V1247545 O Glutaredoxin 125U3 Cluster_657217 V1247546 CUTA S divalent ion tolerance protein COG3323 Cluster_614270 V1247547 FLGJ map00511 N, U flagellar rod assembly protein muramidase flgj COG1705 Cluster_621673 V1247548 S NA 0Y0QM Cluster_261698 V1247549 L Dna topoisomerase COG0550 Cluster_261699 V1247551 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_509979 V1247553 BIOA map00780,map01100 H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) COG0161 Cluster_563822 V1247554 BIOD map00780,map01100 H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) COG0132 Cluster_375332 V1247555 VNCR T response regulator COG0745 Cluster_848096 V1247556 S conjugative transposon protein TraO 0YB3M Cluster_567011 V1247557 MBL D Rod shape-determining protein mreb COG1077 Cluster_549106 V1247560 HTRA map02020,map03010 M serine protease COG0265 Cluster_443023 V1247562 RPSA map00900,map01100,map01110,map03010 J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) COG0539 Cluster_265708 V1247563 YIAY map00010,map00071,map00350,map00362,map00620,map00621,map00622,map00625,map00626,map00630,map00650,map01100,map01110,map01120 C alcohol dehydrogenase COG1454 Cluster_391190 V1247564 S NA 127XX Cluster_649015 V1247565 S Inherit from COG: LOR SDH bifunctional protein conserved domain protein COG1915 Cluster_262994 V1247566 M Inherit from COG: YD repeat protein COG3209 Cluster_264375 V1247567 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_734791 V1247568 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_721631 V1247569 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (alpha subunit) COG0587 Cluster_380607 V1247570 HCAN_0220 S Pfam:DUF395 0XPA5 Cluster_279090 V1247572 S filamentation induced by cAMP protein Fic COG3177 Cluster_264376 V1247573 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_267015 V1247577 S fad dependent oxidoreductase COG2509 Cluster_315360 V1247578 THYX map00240,map00340,map00350,map00624,map00670,map01120 F Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) COG1351 Cluster_267016 V1247582 SELA map00450,map00970 E Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) COG1921 Cluster_579639 V1247583 K DNA-binding helix-turn-helix protein 11XIQ Cluster_268432 V1247584 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_269776 V1247588 YTQA S Radical SAM Protein COG1242 Cluster_276428 V1247589 V abc transporter related protein COG1131 Cluster_758606 V1247591 G transporter major facilitator family protein COG0477 Cluster_324576 V1247592 MCSB map00330 E ATP guanido phosphotransferase COG3869 Cluster_429043 V1247593 YQEK map00760,map01100 H Metal Dependent Phosphohydrolase COG1713 Cluster_773745 V1247594 FEOA P Ferrous iron transport protein A COG1918 Cluster_269777 V1247595 KUP P Transport of potassium into the cell (By similarity) COG3158 Cluster_482739 V1247597 map00300,map01100,map01110,map01120,map01230 E, M Dihydrodipicolinate synthase COG0329 Cluster_427153 V1247598 RECO map03440 L Involved in DNA repair and RecF pathway recombination (By similarity) COG1381 Cluster_515250 V1247599 PORG map00020,map00720,map01100,map01120 C oxidoreductase COG1014 Cluster_543121 V1247600 VORB map00020,map00280,map00720,map01100,map01120 C Thiamine pyrophosphate protein domain protein TPP-binding protein COG1013 Cluster_310763 V1247601 YXBA S ATP-grasp COG3919 Cluster_326073 V1247603 MNME S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 Cluster_437001 V1247605 map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase family protein COG0406 Cluster_840178 V1247606 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_499853 V1247607 K Rrf2 family 12BM4 Cluster_358798 V1247608 ATPB map00190,map00195,map01100 C it plays a direct role in the translocation of protons across the membrane (By similarity) COG0356 Cluster_271081 V1247609 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_275100 V1247611 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_699287 V1247612 CBIN map02010 P Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) COG1930 Cluster_864008 V1247614 K Transcriptional Regulator AraC Family 0ZYR5 Cluster_385931 V1247615 RGPD map02010 P ABC transporter, ATP-binding protein COG1134 Cluster_273741 V1247617 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_724984 V1247618 P arsenate reductase COG1393 Cluster_273742 V1247619 RPSA map00900,map01100,map01110,map03010 J Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) COG0761 Cluster_272414 V1247620 S NA 101UU Cluster_273743 V1247621 S NA 0YCB1 Cluster_762382 V1247623 NDVA2 V ABC transporter, ATP-binding protein COG1132 Cluster_273744 V1247624 CSPA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_273745 V1247625 CBC4_1048 L ISCb1g3, transposase COG3316 Cluster_275101 V1247629 S ABC transporter, ATP-binding protein COG0488 Cluster_482740 V1247630 FUCP G glucose galactose transporter COG0738 Cluster_793127 V1247633 YAAK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) COG0718 Cluster_407103 V1247634 RECR map03440 L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) COG0353 Cluster_391191 V1247635 K CBS Domain protein COG0517 Cluster_695996 V1247637 YLQF K Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) COG1161 Cluster_621675 V1247639 HIT map00230,map00240 F, G histidine triad (hIT) protein COG0537 Cluster_828628 V1247640 RPSU map03010 J 30S ribosomal protein S21 COG0828 Cluster_276429 V1247642 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_316881 V1247643 YQJG O Glutathione S-transferase COG0435 Cluster_276430 V1247645 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_766344 V1247646 S integral membrane protein 11P1U Cluster_708543 V1247648 POTC map02010 P putrescine abc transporter COG1177 Cluster_315361 V1247649 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_277734 V1247650 LDCA V peptidase U61 LD-carboxypeptidase A COG1619 Cluster_283145 V1247652 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit delta' COG1466 Cluster_335090 V1247653 YNBB map00260,map00270,map00450,map01100,map01230 P aluminum resistance protein COG4100 Cluster_280401 V1247655 SNF L SNF2 family COG0553 Cluster_610589 V1247656 map00510,map01100 M Glycosyl transferase family 2 COG0463 Cluster_412538 V1247657 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_306591 V1247660 XYLG S ABC transporter COG3845 Cluster_644929 V1247661 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_425233 V1247662 V Abc transporter COG1132 Cluster_731575 V1247663 S integral membrane protein 11P1U Cluster_365348 V1247665 HPYIM map03430 L Adenine-specific COG3392 Cluster_280403 V1247667 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_507370 V1247668 T anti-sigma regulatory factor serine threonine protein kinase 11VVV Cluster_699288 V1247669 TNAA map00350,map00380 E tryptophanase EC 4.1.99.1 COG3033 Cluster_507371 V1247671 ISPLU5A L transposase COG1943 Cluster_469397 V1247672 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_280404 V1247674 M NA 0ZYVM Cluster_384155 V1247676 S NA 128C9 Cluster_352107 V1247677 RUMAL_0348 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_299488 V1247678 S F420-0:Gamma-glutamyl ligase 0Y085 Cluster_287368 V1247679 CSM1 L Crispr-associated protein, Csm1 family COG1353 Cluster_280406 V1247680 GALE map00052,map00520,map01100,map01110 M udp-glucose 4-epimerase COG1087 Cluster_329117 V1247681 THIC map00730,map01100 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) COG0422 Cluster_281735 V1247682 CADA P heavy metal translocating P-type ATPase COG2217 Cluster_352108 V1247683 M Ompa motb domain protein COG2885 Cluster_582883 V1247684 PRIA map03440 L Primosomal protein n' COG1198 Cluster_417994 V1247685 S Inherit from COG: ATPase (AAA COG1373 Cluster_560837 V1247686 PIRIN O pirin domain protein COG1741 Cluster_678762 V1247687 L Membrane COG4905 Cluster_283146 V1247688 CAS3 L CRISPR-associated helicase, cas3 COG1203 Cluster_412539 V1247690 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_482741 V1247692 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_283148 V1247695 MUTL map03430 L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) COG0323 Cluster_283149 V1247697 map02010 P ATP-binding protein COG1122 Cluster_433029 V1247699 BAS2534 S Hydrolase COG1011 Cluster_403628 V1247700 T Regulator COG0745 Cluster_456951 V1247701 PAAG I Enoyl-CoA hydratase COG1024 Cluster_573293 V1247702 LDTA S ErfK YbiS YcfS YnhG COG1376 Cluster_407104 V1247704 ILVE map00790 E, H Chorismate binding enzyme COG0115 Cluster_285965 V1247705 M Sulfatase COG1368 Cluster_284520 V1247706 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_285966 V1247707 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_285967 V1247708 S DNA polymerase iii 101FB Cluster_502384 V1247710 IR2 map02020 T response regulator COG3279 Cluster_285968 V1247712 P abc transporter permease protein 0ZFR9 Cluster_687736 V1247713 YAAK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) COG0718 Cluster_463105 V1247714 RUMAL_0348 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_287369 V1247716 M Inherit from COG: YD repeat protein COG3209 Cluster_321430 V1247717 S Domain of unknown function DUF87 0ZJHN Cluster_382386 V1247720 RPE map00030,map00040,map00710,map01100,map01110,map01120,map01230 G ribulose-phosphate 3-epimerase COG0036 Cluster_797104 V1247722 FDXA C Ferredoxin COG1146 Cluster_345780 V1247723 M Cell Wall COG5263 Cluster_456952 V1247724 TAGH map02010 G, M ABC transporter COG3754 Cluster_288730 V1247726 M domain protein COG4932 Cluster_327630 V1247729 PBP1B map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_437002 V1247731 FBP map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120 G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 COG3855 Cluster_809266 V1247732 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_437003 V1247733 PURN map00230,map00670,map01100,map01110 F phosphoribosylglycinamide formyltransferase COG0299 Cluster_554880 V1247734 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_540216 V1247735 S Phospholipase, patatin family 0YEF4 Cluster_288731 V1247736 ACDA map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I Acyl-coa dehydrogenase COG2025 Cluster_290010 V1247737 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_290011 V1247738 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_288732 V1247739 SSAG_00936 L Transposase 0XNRT Cluster_363609 V1247740 BMUL_3003 S Membrane COG3619 Cluster_290012 V1247741 METY map00270,map00450,map00920,map01100,map01110,map01230 E Cys/Met metabolism PLP-dependent enzyme COG2873 Cluster_665637 V1247742 GLYQS map00970 J Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) COG0423 Cluster_758607 V1247743 TYPA T gtp-binding protein typa COG1217 Cluster_509980 V1247744 THIC map00730,map01100 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) COG0422 Cluster_596222 V1247745 LKTB3 V ABC transporter, ATP-binding protein COG2274 Cluster_502385 V1247746 S NA 0ZHU9 Cluster_410726 V1247749 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_471561 V1247750 YNHI map00900,map01110 S heptaprenyl diphosphate synthase component I COG4769 Cluster_674311 V1247751 YNHH map00900,map01110 S protein, conserved in bacteria COG5341 Cluster_313778 V1247752 V ABC transporter COG1132 Cluster_554881 V1247755 S AP2 domain 123DH Cluster_290013 V1247757 SP_0483 map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_291327 V1247759 M domain protein COG4932 Cluster_497188 V1247760 RPSG map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) COG0049 Cluster_560838 V1247763 K Transcriptional regulator COG3682 Cluster_302251 V1247764 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_396602 V1247765 map00630,map01100,map01110 F IA, variant 1 COG0546 Cluster_517919 V1247767 S domain protein COG1917 Cluster_318462 V1247768 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_363610 V1247769 YEEN K transcriptional regulatory protein COG0217 Cluster_292679 V1247770 HYDG map00730,map01100 H biosynthesis protein thiH COG1060 Cluster_385932 V1247773 V abc transporter permease protein COG0577 Cluster_625477 V1247775 map03060,map03070 U Preprotein translocase subunit COG1862 Cluster_347373 V1247777 S Plasmid pRiA4b ORF-3 family protein 11TVE Cluster_295470 V1247778 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0587 Cluster_296817 V1247780 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_421564 V1247782 L Transposase 11X46 Cluster_888166 V1247784 VEX2 V abc transporter atp-binding protein COG1136 Cluster_687737 V1247785 HEMN map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_295471 V1247786 D domain protein 0XTIC Cluster_805237 V1247787 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_592746 V1247788 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G Phosphohexokinase COG0205 Cluster_380608 V1247789 S corrinoid protein 11G0X Cluster_492193 V1247791 TNAB E Tryptophan transporter of low affinity COG0814 Cluster_296818 V1247792 TIG O Peptidyl-prolyl cis-trans isomerase COG0545 Cluster_298206 V1247794 map00550 M Penicillin-binding Protein dimerisation domain COG0772 Cluster_400060 V1247795 S Membrane COG2035 Cluster_296819 V1247796 FLUTA_0256 L Transposase COG3464 Cluster_724985 V1247797 map00330 S Alpha Beta Hydrolase COG0596 Cluster_305201 V1247798 TYPA T gtp-binding protein typa COG1217 Cluster_485059 V1247799 RIBF map00740,map01100 H riboflavin biosynthesis protein ribF COG0196 Cluster_382387 V1247800 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_369979 V1024602 HSDS V type I restriction-modification system COG0732 Cluster_796127 V1024603 MTR map00010,map00020,map00260,map00280,map00480,map00620,map01100,map01110,map01120 C pyridine nucleotide-disulfide oxidoreductase COG1249 Cluster_366699 V1024606 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_677645 V1024607 S NA 0ZWJI Cluster_368328 V1024609 S NA 0ZN4K Cluster_605950 V1024611 YNIA map00564,map01100 G Fructosamine kinase COG3001 Cluster_381961 V1024612 L helicase COG0553 Cluster_631970 V1024614 S NA 0ZHU9 Cluster_664542 V1024615 LACF map00052,map01100,map02060 G PTS System COG1447 Cluster_704630 V1024616 S Signal peptide protein 189GH@proNOG Cluster_677646 V1024617 LIPA map00785,map01100 H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) COG0320 Cluster_588487 V1024618 LLMG_0050 L IstB domain-containing protein ATP-binding protein COG1484 Cluster_369980 V1024619 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_369981 V1024620 WBPC I Acyl-transferase COG1835 Cluster_471000 V1024621 S NA 0ZHU9 Cluster_569257 V1024623 YGIW S exported protein COG3111 Cluster_569258 V1024627 S Membrane 11UEJ Cluster_456488 V1024628 FLIC map02020,map02040,map04626,map05132,map05134 N Flagellin COG1344 Cluster_434466 V1024629 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_551268 V1024630 ACX map00071,map00592,map01040,map01100,map03320,map04146 I acyl-CoA oxidase COG1960 Cluster_369983 V1024636 S PbH1 11GWR Cluster_548293 V1024637 YDAT S Uncharacterized protein conserved in bacteria (DUF2188) COG4876 Cluster_613279 V1024638 MALQ map00500,map01100,map01110 G 4-alpha-glucanotransferase COG1640 Cluster_369984 V1024642 BMUL_3652 V Abortive infection bacteriophage resistance protein COG4823 Cluster_695155 V1024643 YHBY J Rna-binding protein COG1534 Cluster_491604 V1024645 Y0354 O Glutamine cyclotransferase COG3823 Cluster_602329 V1024648 map02010 E ABC transporter COG0411 Cluster_792178 V1024649 map02010 E ABC transporter COG0410 Cluster_369985 V1024650 S NA 11VF8 Cluster_401409 V1024651 S NA 1258K Cluster_456489 V1024652 TNP3508A L Transposase COG3328 Cluster_560071 V1024654 L Pfam:Transposase_7 COG4644 Cluster_471001 V1024655 NUSA K Transcription elongation factor NusA COG0195 Cluster_701622 V1024658 AMIA M n-acetylmuramoyl-l-alanine amidase COG0860 Cluster_462594 V1024659 BMUL_1308 map00230,map01100 F Ohcu decarboxylase COG3195 Cluster_369986 V1024660 TADC U type II secretion system protein COG2064 Cluster_371637 V1024661 map00633,map01120 C nitroreductase COG0778 Cluster_371638 V1024662 DNAE2 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase (By similarity) COG0587 Cluster_862979 V1024664 RPMI map03010 J 50S ribosomal protein L35 COG0291 Cluster_588488 V1024665 RPLT map03010 J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) COG0292 Cluster_517253 V1024666 S Terminase large subunit COG4626 Cluster_750737 V1024667 S phosphopyruvate hydratase 17AKI@proNOG Cluster_588489 V1024669 S NA 0YEUF Cluster_371639 V1024670 U TraG family COG3505 Cluster_572454 V1024672 YUTD S transcriptional regulator COG4470 Cluster_879027 V1024673 S NA 0ZHU9 Cluster_371640 V1024674 K Transcriptional Regulator AraC Family COG3664 Cluster_371641 V1024675 G Major Facilitator superfamily 0Z6XG Cluster_404976 V1024677 YTFP S hi0933 family COG2081 Cluster_373258 V1024681 RV0495C S NA 0ZV27 Cluster_373259 V1024682 S methyltransferase 0ZVPT Cluster_491605 V1024687 LGAS_0606 S Phage Portal Protein 0XP33 Cluster_517254 V1024688 TCMP map00340,map00350,map00624,map01120 Q O-Methyltransferase COG3315 Cluster_373260 V1024691 PHOD map00627,map00790,map01100,map01120,map02020 P Alkaline phosphatase COG3540 Cluster_776552 V1024692 RPLK map03010 J This protein binds directly to 23S ribosomal RNA (By similarity) COG0080 Cluster_624508 V1024693 FADD35 map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG0318 Cluster_701623 V1024694 S MaoC domain protein dehydratase 17JYT@proNOG Cluster_557022 V1024695 RPLL map03010 J Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) COG0222 Cluster_373261 V1024699 YOAT S Membrane COG3739 Cluster_473129 V1024702 L CRISPR-associated protein Cse2 (CRISPR_cse2) 0ZKX4 Cluster_562976 V1024703 TOPB L Dna topoisomerase COG0550 Cluster_373262 V1024708 YOBI S NA 0XPR9 Cluster_374960 V1024709 L Inherit from COG: Helicase COG1112 Cluster_374961 V1024711 CPDB map00230,map00240,map00760,map01100,map01110 F 5-nucleotidase COG0737 Cluster_404977 V1024712 LOLD V abc transporter atp-binding protein COG1136 Cluster_733939 V1024717 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_660328 V1024718 J Elongation factor Tu GTP binding domain COG0050 Cluster_374962 V1024719 MURG map00550,map01100,map04112 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) COG0707 Cluster_509308 V1024721 YICE F permease COG2233 Cluster_562977 V1024728 LGAS_0606 S Phage Portal Protein 0XP33 Cluster_733940 V1024729 L Phage terminase, large subunit COG1783 Cluster_720792 V1024731 TDK map00240,map00983,map01100 F thymidine kinase COG1435 Cluster_660329 V1024736 S helix-turn-helix domain protein 122WR Cluster_727377 V1024737 HSDR V type I restriction enzyme EcoKI subunit R COG4096 Cluster_850861 V1024739 S NA 0ZHU9 Cluster_378478 V1024742 S Replication initiator protein 11Z32 Cluster_376678 V1024743 S conjugation system ATPase, TraG family 0XSHU Cluster_554134 V1024744 YGFX S Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB 17F2M@proNOG Cluster_757748 V1024745 K transcriptional regulator MERR family COG0789 Cluster_620759 V1024746 FECE map02010 P ABC transporter, ATP-binding protein COG1120 Cluster_468897 V1024748 S Terminase, large subunit COG1783 Cluster_381962 V1024754 REP L Replication Protein COG5527 Cluster_769177 V1024756 PURA map00230,map00250,map01100 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis COG0104 Cluster_656183 V1024757 GPT S Phosphoribosyltransferase COG2236 Cluster_724169 V1024759 GROS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) COG0234 Cluster_376680 V1024760 E Inherit from COG: zinc metalloprotease COG3227 Cluster_376681 V1024761 ATPB map00190,map00195,map01100 C it plays a direct role in the translocation of protons across the membrane (By similarity) COG0356 Cluster_376682 V1024762 map00270,map00450,map00670,map01100,map01110,map01230 E Methionine synthase COG1410 Cluster_458414 V1024763 S NA 0ZHU9 Cluster_733941 V1024764 PTH_0213 L Integrase COG0582 Cluster_839021 V1024765 PTH_0213 L Integrase COG0582 Cluster_401410 V1024772 GRDD S fatty acid phospholipid synthesis protein plsX 0XQ1G Cluster_381963 V1024775 S PbH1 11GWR Cluster_376683 V1024776 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_624509 V1024781 M Membrane 123ZG Cluster_566165 V1024782 S Type II DNA modification methyltransferase 0ZM02 Cluster_378479 V1024783 SPEB S peptidase C10 11SDT Cluster_733942 V1024787 S Protein of unknown function (DUF3343) 181AE@proNOG Cluster_517255 V1024788 SMG S Protein smg homolog COG2922 Cluster_378480 V1024793 S NA COG5412 Cluster_784365 V1024794 S NA 11SFQ Cluster_525424 V1024795 AMID2 M n-acetylmuramoyl-l-alanine amidase 124HM Cluster_542270 V1024799 S NA 0YC0J Cluster_458936 V1247802 Q Isochorismatase family COG1335 Cluster_299489 V1247804 PEPN map00480,map01100 E Aminopeptidase COG0308 Cluster_455008 V1247805 S NA 0Z81M Cluster_618030 V1247806 NAGA map00520,map01110 G GlcNAc 6-P deacetylase COG1820 Cluster_465191 V1247807 G transporter 0XPWC Cluster_425234 V1247809 MSRA S methionine sulfoxide reductase A 0YJ5R Cluster_504790 V1247811 APPA E Extracellular solute-binding protein, family 5 COG0747 Cluster_377102 V1247813 FNI map00900,map01100,map01110 C Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) COG1304 Cluster_621676 V1247814 PLSX map00561,map00564,map01100 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) COG0416 Cluster_299490 V1247816 RNC map03008,map05205 K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) COG0571 Cluster_339590 V1247817 VICK map02020 T Histidine kinase 0XNMH Cluster_576525 V1247818 YCCF S Membrane COG3304 Cluster_300871 V1247819 T Histidine kinase COG2972 Cluster_497189 V1247820 E ABC transporter substrate-binding protein COG0834 Cluster_300872 V1247823 MURD map00471,map00550,map01100 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COG0771 Cluster_300873 V1247824 S Inherit from NOG: LPXTG-motif cell wall anchor domain protein 0YEBJ Cluster_629163 V1247828 S RNA polymerase Rpb6 11RMF Cluster_300874 V1247830 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_333586 V1247831 UMUC L Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) COG0389 Cluster_300875 V1247834 S NA 11FBZ Cluster_302252 V1247835 S Uncharacterized conserved protein (DUF2075) 0XPB6 Cluster_330522 V1247836 CYCMA_1561 L Transposase COG3436 Cluster_751622 V1247837 NADD map00230,map00760,map01100,map05340 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) COG1057 Cluster_368668 V1247840 PYRF map00240,map01100 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) COG0284 Cluster_439042 V1247841 MAA map00350,map00362,map00627,map00642,map00903,map01120 S Maltose acetyltransferase COG0110 Cluster_447064 V1247843 PUUR K Transcriptional regulator COG1396 Cluster_330523 V1247846 GLTS E Sodium Glutamate Symporter COG0786 Cluster_303698 V1247849 M RHS repeat-associated core domain protein COG3209 Cluster_393006 V1247852 CCEL_1484 L Integrase COG2801 Cluster_303699 V1247853 S NA 0XWEM Cluster_824827 V1247856 S NA 11VZN Cluster_305202 V1247858 S peptidase, S41 11U77 Cluster_421565 V1247859 S Conjugative transposon TraN protein 0XNQ2 Cluster_669924 V1247860 S NA 128RN Cluster_625478 V1247861 S NA 0Y0CD Cluster_649016 V1247863 MDLA V ABC transporter, ATP-binding protein COG1132 Cluster_596223 V1247864 S Prophage pi2 protein 37 11UE0 Cluster_305203 V1247866 ADDB L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination COG3857 Cluster_305204 V1247867 ATPA map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) COG1155 Cluster_398327 V1247868 L phage plasmid primase, p4 family COG3378 Cluster_517920 V1247869 THIE map00730,map01100 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) COG0352 Cluster_621677 V1247870 THIH map00730,map01100 H biosynthesis protein thiH COG1060 Cluster_305205 V1247871 YAAT S psp1 domain protein COG1774 Cluster_353767 V1247872 S NA 0YRA4 Cluster_665638 V1247875 SEPF S Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) COG1799 Cluster_318463 V1247877 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_305207 V1247881 ASPA map00250,map00910,map01100 E Aspartate ammonia-lyase COG1027 Cluster_695997 V1247884 S NA 0Y7U9 Cluster_687738 V1247885 S NA 0YSUR Cluster_567012 V1247886 LYTR2 K TRANSCRIPTIONal COG1316 Cluster_599728 V1247887 THIJ map05012 T DJ-1 family COG0693 Cluster_370367 V1247889 S Membrane 12424 Cluster_309317 V1247891 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_306592 V1247892 MGTE P magnesium transporter COG2239 Cluster_528917 V1247893 T Histidine kinase COG0642 Cluster_378888 V1247894 TNP L transposase COG1943 Cluster_573294 V1247897 L Dna topoisomerase COG0550 Cluster_309318 V1247901 MYCA S Myosin-Cross-Reactive Antigen COG4716 Cluster_520486 V1247902 S Uncharacterised protein, DegV family COG1307 0YGG8 Cluster_512548 V1247903 LACA map00052,map01100 G Galactose-6-phosphate isomerase subunit LacA COG0698 Cluster_309319 V1247904 URAA F permease COG2233 Cluster_801042 V1247905 S NA 0YCKF Cluster_309320 V1247907 I Acyl-transferase COG0204 Cluster_330524 V1247909 PURF map00230,map00250,map01100,map01110 F glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_384156 V1247910 GLTD map00250,map00910,map01100,map01110,map01120,map01230 C, E pyridine nucleotide-disulfide oxidoreductase COG1894 Cluster_389462 V1247911 VMRA V Mate efflux family protein COG0534 Cluster_312280 V1247913 S NA 101UU Cluster_482742 V1247914 S Domain of unknown function DUF87 0ZJHN Cluster_310764 V1247915 ISPG map00900,map01100,map01110 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) COG0821 Cluster_312281 V1247916 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_871960 V1247918 S NA 12ASP Cluster_463106 V1247920 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_657219 V1247921 map00052,map01100,map02060 G PTS system, IIB component COG3414 Cluster_702353 V1247924 RLMB map00340,map00350,map00624,map01120 J RNA methyltransferase TrmH family group 3 COG0566 Cluster_405439 V1247926 YHBB2 S NA 11IEN Cluster_528918 V1247929 COMEC S DNA internalization-related competence protein ComEC Rec2 COG2333 Cluster_773746 V1247930 YYZM S protein, conserved in bacteria COG4481 Cluster_718326 V1247931 S NA 1236P Cluster_313779 V1247932 LANM V Lanthionine synthetase C family protein COG4403 Cluster_421566 V1247934 ILVC map00290,map00770,map01100,map01110,map01210,map01230 E Alpha-keto-beta-hydroxylacyl reductoisomerase COG0059 Cluster_554883 V1247936 SP_1023 map00350,map00362,map00627,map00642,map00903,map01120 K Acetyltransferase GNAT Family COG0454 Cluster_321431 V1247937 LDTA S ErfK YbiS YcfS YnhG COG1376 Cluster_318464 V1247939 S Protein of unknown function (DUF3160) 0XRJH Cluster_412540 V1247940 S NA 11X7Q Cluster_711687 V1247943 SUFB O FeS assembly protein SUFB COG0719 Cluster_405440 V1247944 FECD map02010 P transport system permease protein COG0609 Cluster_315362 V1247946 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_316882 V1247950 K Transcriptional regulator GntR family COG1167 Cluster_724987 V1247951 YRZL S UPF0297 protein COG4472 Cluster_543122 V1247952 RUVX L Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) COG0816 Cluster_315363 V1247953 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_589377 V1247954 S membrAne 120XT Cluster_318465 V1247955 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_375333 V1247956 S NA 0XSI9 Cluster_322993 V1247957 CYAA map00230,map05111 F Adenylate cyclase COG3072 Cluster_410727 V1247958 S NA 122KH Cluster_336621 V1247959 VORB map00020,map00280,map00720,map01100,map01120 C Ferredoxin COG0674 Cluster_318466 V1247960 S NA 0YD1F Cluster_427154 V1247962 FTSQ map04112 M domain protein, FtsQ-type COG1589 Cluster_316883 V1247963 XYLG S ABC transporter COG3845 Cluster_318467 V1247965 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_762385 V1247966 S selenoprotein B, glycine betaine sarcosine D-proline reductase 123JW Cluster_576526 V1247969 FTSI map00550,map01100 M penicillin-binding protein COG0768 Cluster_467283 V1247970 S Hydrolase COG0561 Cluster_410728 V1247971 PYRE map00240,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_318469 V1247972 NIST map02010 V ABC transporter 0XPIZ Cluster_319949 V1247973 DPNA L helicase COG4646 Cluster_342564 V1247975 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_319950 V1247976 S amidinotransferase COG4874 Cluster_734793 V1247977 J rrna methyltransferase COG0566 Cluster_724988 V1247978 AMPH map00311,map00312,map01110,map02020 V beta-lactam binding protein AmpH COG1680 Cluster_864011 V1247979 KT71_14019 L Inherit from COG: transposase COG3464 Cluster_773747 V1247981 RPSR map03010 J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) COG0238 Cluster_463107 V1247982 CARD K Transcriptional regulator (CarD family COG1329 Cluster_610591 V1247985 HSDS V Restriction modification system DNA (Specificity COG0732 Cluster_603302 V1247986 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_649017 V1247988 K Transcriptional regulator, TetR family 0ZXSC Cluster_321432 V1247990 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_437004 V1247991 DAPB map00300,map01100,map01110,map01120,map01230 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) COG0289 Cluster_721632 V1247993 S NA 0ZHU9 Cluster_502386 V1247994 RBSD map02010 G Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) COG1869 Cluster_434942 V1247996 S NA 0Z34Z Cluster_410729 V1247997 CSN1 L CRISPR-associated protein, Csn1 family COG3513 Cluster_563823 V1247998 S NA 0YF9C Cluster_455009 V1247999 P ABC transporter substrate-binding protein 0XTCH Cluster_382388 V1248000 RPSB map03010 J 30S ribosomal protein S2 COG0052 Cluster_324577 V1248003 BH0416 L Transposase COG3464 Cluster_534532 V1248004 GALK map00052,map00520,map01100,map01110 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) COG0153 Cluster_322994 V1248005 S copper amine 121X1 Cluster_637061 V1248006 CCA map03013,map03018 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate COG0617 Cluster_610592 V1248009 C Nitrite and sulphite reductase 4Fe-4S domain COG2221 Cluster_509981 V1248010 SP_1358 map02010 V ABC transporter transmembrane region COG1132 Cluster_324578 V1248011 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_326074 V1248014 L Recombinase COG1961 Cluster_537417 V1248015 S NA 11TBU Cluster_372004 V1248016 REX K Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) COG2344 Cluster_345781 V1248019 LPDA map00010,map00020,map00260,map00280,map00620,map01100,map01110,map01120 C dihydrolipoyl dehydrogenase COG1249 Cluster_339591 V1248020 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_327631 V1248022 BDHA map00051,map00363,map00591,map00625,map00650,map01100,map01120 C alcohol dehydrogenase COG1979 Cluster_644930 V1248023 S NA 0XW6Q Cluster_507372 V1248026 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_708545 V1248027 YLXM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) COG2739 Cluster_326075 V1248028 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_509982 V1248030 RPLM map03010 J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) COG0102 Cluster_327632 V1248032 S NA 0ZPB7 Cluster_434943 V1248033 CARA map00240,map00250,map01100 F carbamoyl-phosphate synthetase glutamine chain COG0505 Cluster_487348 V1248035 PRIA map03440 L Primosomal protein n' COG1198 Cluster_329118 V1248036 P tonB-dependent Receptor 0XNUH Cluster_327633 V1248037 T Tetratricopeptide repeat 0XQ1K Cluster_517921 V1248038 K Transcriptional regulator (AraC family) 11K8N Cluster_467284 V1248039 S Membrane COG2119 Cluster_711688 V1248041 S NA 0YF8K Cluster_394824 V1248043 H Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) COG1020 Cluster_329120 V1248046 S NA 0YG6V Cluster_372005 V1248047 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_417995 V1248049 YQFA S UPF0365 protein COG4864 Cluster_502387 V1248050 BPR_I0156 L transposase COG1943 Cluster_549107 V1248051 S NA 11QC5 Cluster_412541 V1248054 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_352109 V1248055 THYA map00240,map00670,map01100 F Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) COG0207 Cluster_365349 V1248057 NATA S (ABC) transporter COG4152 Cluster_724989 V1248058 K Inherit from COG: Transcriptional regulator COG2865 Cluster_414416 V1248059 M Sulfatase COG1368 Cluster_416192 V1248062 YDIU S UPF0061 protein COG0397 Cluster_731577 V1248063 YUGP S zinc metallopeptidase COG2738 Cluster_460990 V1248064 N ppe family COG5651 Cluster_385933 V1248067 LEXA K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) COG1974 Cluster_330528 V1248069 BMUL_3599 map02010 P ABC transporter COG1129 Cluster_517922 V1248070 YXBA S ATP-grasp COG3919 Cluster_770063 V1248071 V Mate efflux family protein COG0534 Cluster_357131 V1248072 GLOB map00620 C Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) COG0491 Cluster_330529 V1248073 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_494675 V1248074 CTSR K transcriptional regulator, ctsr COG4463 Cluster_570092 V1248075 S acetyltransferase, (GNAT) family 121KY Cluster_460991 V1248076 STRCR_0250 S transposase 123R5 Cluster_332074 V1248077 MCRB V ATPase associated with various cellular activities aaa_5 COG1401 Cluster_332075 V1248080 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_332076 V1248081 DCTA map02020 C sodium dicarboxylate symporter COG1301 Cluster_332077 V1248082 S NA 0YC46 Cluster_332078 V1248083 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_567014 V1248084 CSD1 L CRISPR-associated protein Csd1 family 0ZVNC Cluster_618032 V1248085 L CRISPR-associated protein Csd2 COG3649 Cluster_332079 V1248086 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_449082 V1248087 ATPH map00190,map00195,map01100 C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) 121DF Cluster_332080 V1248088 RIBBA map00740,map01100 H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) COG0807 Cluster_400061 V1248092 RSEP map04112 M Membrane-associated zinc metalloprotease COG0750 Cluster_487350 V1248093 NADC map00760,map01100 H nicotinate-nucleotide pyrophosphorylase COG0157 Cluster_755090 V1248094 NADA map00760,map01100 H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) COG0379 Cluster_332081 V1248095 V Mate efflux family protein COG0534 Cluster_333587 V1248096 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_332082 V1248099 map02010 V ABC, transporter COG2274 Cluster_515253 V1248100 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_554884 V1248102 RPLK map03010 J This protein binds directly to 23S ribosomal RNA (By similarity) COG0080 Cluster_394825 V1248103 SUA J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0009 Cluster_389463 V1248104 RSUA J Pseudouridine synthase COG1187 Cluster_465192 V1248108 J -acetyltransferase COG1670 Cluster_335091 V1248109 MUTL2 S dna mismatch repair 0XRIS Cluster_341051 V1248110 S relaxase mobilization nuclease domain protein 0XNXG Cluster_437005 V1248112 RNFA C Electron transport complex COG4657 Cluster_335092 V1248113 ALR map00300,map00473,map00550,map01100 M Alanine racemase COG0787 Cluster_336622 V1248114 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_485060 V1248115 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_485061 V1248117 S Phage replisome organizer 0YDCP Cluster_336623 V1248118 SCLAV_1921 map02010 V abc transporter COG1132 Cluster_441022 V1248119 V type I restriction-modification system COG0286 Cluster_372006 V1248120 APPD map02010 E, P ABC transporter COG0444 Cluster_721633 V1248121 RPSO map03010 J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) COG0184 Cluster_336624 V1248122 THRC map00260,map00750,map01100,map01120,map01230 E Threonine synthase COG0498 Cluster_336625 V1248123 S NA 0YHNP Cluster_336626 V1248124 L Inherit from COG: DNA Methylase COG0827 Cluster_338168 V1248126 FTSK D cell division protein FtsK COG1674 Cluster_377103 V1248127 YGCG S of methanol dehydrogenase type COG1512 Cluster_465193 V1248128 K M protein trans-acting positive regulator 0Y0QQ Cluster_336627 V1248129 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_338169 V1248131 CCPA K Transcriptional regulator COG1609 Cluster_338170 V1248132 CTPC map00190 P heavy metal translocating P-type ATPase COG2217 Cluster_592748 V1248133 YHCG V abc transporter atp-binding protein COG1131 Cluster_338171 V1248134 K Inherit from firmNOG: Transcriptional regulator COG2865 Cluster_338172 V1248135 M YD repeat protein COG3209 Cluster_582884 V1248136 S Protein of unknown function (DUF2089) COG3877 Cluster_586078 V1248137 RPLT map03010 J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) COG0292 Cluster_393007 V1248139 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_378889 V1248141 L Recombinase COG1961 Cluster_407105 V1248142 S (LipO)protein 0XSFR Cluster_355438 V1248145 UGPE map02010 P binding-protein-dependent transport systems inner membrane component COG0395 Cluster_412542 V1248146 BCELL_1025 L Transposase COG2801 Cluster_661424 V1248147 S NA 1030P Cluster_551982 V1248148 K Inherit from COG: Transcriptional regulator COG2508 Cluster_339592 V1248149 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_339593 V1248150 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG2812 Cluster_378890 V1248151 map00310,map00780,map01100 O peptidase, M16 COG0612 Cluster_357132 V1248152 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_339594 V1248153 M Sulfatase COG1368 Cluster_478016 V1248154 S copper amine 121X1 Cluster_433031 V1248156 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_724990 V1248157 CLOSA_1745 L transposase COG2963 Cluster_724991 V1248158 CLOSA_1745 L transposase COG2963 Cluster_475819 V1248159 map00051 M glycosyl transferase group 1 COG0438 Cluster_407106 V1248163 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120 G phosphohexose isomerase COG0166 Cluster_696000 V1248165 NRFA map00910,map01120,map05132 P Plays a role in nitrite reduction (By similarity) COG3303 Cluster_755091 V1248166 NRFA map00910,map01120,map05132 P Plays a role in nitrite reduction (By similarity) COG3303 Cluster_380609 V1248168 S domain protein 12C1H Cluster_567015 V1248170 S NA 11HZ6 Cluster_387752 V1248171 OPPB map02010 P ABC transporter (permease) COG0601 Cluster_832382 V1248174 S NA COG3937 Cluster_692229 V1248176 S NA 0YFUK Cluster_925577 V1248180 RPMB map03010 J 50S ribosomal protein l28 COG0227 Cluster_801044 V1248181 S Regulatory protein, FmdB family 0ZXXF Cluster_403629 V1248182 AMD map00360 E amidohydrolase COG1473 Cluster_629164 V1248183 S tcdA-E operon negative regulator 125I9 Cluster_724992 V1248184 S radical SAM domain protein COG4422 Cluster_526150 V1248185 SP_1863 K Transcriptional regulator, MarR family COG1846 Cluster_342565 V1248186 PQQE K radical SAM domain protein COG1522 Cluster_382390 V1248187 VICX map03013 S domain protein COG1235 Cluster_452989 V1248191 map03420,map03430 L helicase COG0210 Cluster_478017 V1248192 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_487351 V1248194 S Pfam:DUF124 COG2013 Cluster_781239 V1248195 MT3820 M n-acetylmuramoyl-l-alanine amidase COG0860 Cluster_412543 V1248196 O glycyl-radical enzyme activating protein family COG1180 Cluster_721634 V1248197 GCVR T UPF0237 protein COG3830 Cluster_644931 V1248199 YBJQ S UPF0145 protein COG0393 Cluster_382391 V1248200 REX K Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) COG2344 Cluster_715069 V1248201 YHGI O NifU domain protein COG0694 Cluster_344166 V1248202 YHEH V ABC transporter COG1132 Cluster_618033 V1248203 GLPP K glycerol-3-phosphate responsive antiterminator COG1954 Cluster_586079 V1248204 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_661425 V1248205 COMEB map00240,map01100 F deaminase COG2131 Cluster_412544 V1248206 RBSK map00030 G ribokinase COG0524 Cluster_345782 V1248207 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_345783 V1248208 L Recombinase COG1961 Cluster_447065 V1248209 P phosphonate ABC transporter substrate-binding protein COG3221 Cluster_410730 V1248211 S NA 0Y9TM Cluster_345784 V1248212 VICK map02020 T Histidine kinase 0XNMH Cluster_443024 V1248213 F ATP cone domain COG1328 Cluster_347374 V1248220 C FMN-binding domain protein COG3976 Cluster_463108 V1248223 K transcriptional regulator COG1737 Cluster_347375 V1248225 DCMB map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_347376 V1248226 FADA map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120 I acetyl-coa acetyltransferase COG0183 Cluster_471562 V1248227 YKHA map00903,map01040 I thioesterase Superfamily protein COG1607 Cluster_633014 V1248231 RNPA J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) 125AC Cluster_375334 V1248232 MANX map00051,map00520,map01100,map02060 G pts system COG3444 Cluster_347377 V1248233 HSDR V Type I Restriction COG0610 Cluster_467285 V1248235 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_549108 V1248236 PYRK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) COG0543 Cluster_348981 V1248237 S phage tail tape measure protein COG5412 Cluster_368669 V1248239 GLGA map00500,map01100,map01110,map04973 G Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) COG0297 Cluster_633015 V1248240 RPLQ map03010 J 50S ribosomal protein l17 COG0203 Cluster_499854 V1248241 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_489697 V1248242 FUCO map00620,map00630,map01120 C alcohol dehydrogenase COG1454 Cluster_372007 V1248245 S Methyltransferase 11REP Cluster_441023 V1248246 V ABC transporter COG1132 Cluster_348983 V1248247 P Secretin and TonB N terminus short domain 0Y9Y0 Cluster_696002 V1248249 WS0013 S membrAne 0XPGN Cluster_551983 V1248250 S Nitrogen regulatory protein P-II 11PAT Cluster_348984 V1248251 E Extracellular solute-binding protein, family 5 COG0747 Cluster_350606 V1248253 NDVA2 V ABC transporter, ATP-binding protein COG1132 Cluster_403630 V1248255 S Inherit from NOG: domain protein 0XP4A Cluster_357133 V1248258 SACC map00052,map00500,map01100 G sucrose-6-phosphate hydrolase COG1621 Cluster_456953 V1248259 LICD M licD family COG3475 Cluster_350607 V1248261 YXCA I coA-substrate-specific enzyme activase COG3581 Cluster_603304 V1248262 MSRA O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) COG0225 Cluster_350608 V1248263 SURB S G5 domain protein 0ZVV3 Cluster_373624 V1248264 map00040,map00051,map01100 G xylose isomerase COG4952 Cluster_560840 V1248265 map02010 P ABC, transporter COG1108 Cluster_352110 V1248266 P TrkA-N domain protein COG1226 Cluster_352111 V1248268 S radical SAM domain protein COG0535 Cluster_573296 V1248269 S Toxin-antitoxin system, antitoxin component, HicB family 12518 Cluster_809269 V1248270 S YcfA-like protein 0Z424 Cluster_352112 V1248274 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_637063 V1248276 S EamA-like transporter family 10299 Cluster_363612 V1248277 L Recombinase COG1961 Cluster_512549 V1248279 LUXS map00270,map05111 T Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) COG1854 Cluster_352113 V1248280 S Phage tail tape measure protein, TP901 family 10QPB Cluster_644932 V1248282 S plasmid recombination enzyme 0YGA3 Cluster_674313 V1248284 LRGB map02020 M lrgb family COG1346 Cluster_868003 V1248285 RADC L DNA repair protein (RadC COG2003 Cluster_449083 V1248286 map01040 E lipolytic protein G-D-S-L family COG2755 Cluster_456954 V1248287 FLAR F topology modulation protein COG0563 Cluster_586080 V1248289 PYRK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) COG0543 Cluster_419776 V1248290 PSTC map02010 P phosphate abc transporter COG0573 Cluster_352114 V1248291 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_534534 V1248292 PGN_0048 S NA 0YI97 Cluster_848099 V1248295 YEIE K Transcriptional regulator, LysR family COG0583 Cluster_353768 V1248296 S FN3 0ZU8F Cluster_353769 V1248298 OPPB1 P Binding-protein-dependent transport systems inner membrane component COG0601 Cluster_353770 V1248299 CPAB U Flp pilus assembly protein CpaB 11X1U Cluster_353771 V1248300 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_355439 V1248303 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_403631 V1248304 L Recombinase COG1961 Cluster_353772 V1248305 YLBM S UPF0348 protein COG1323 Cluster_355440 V1248307 PSUG map00240 Q Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) COG2313 Cluster_487353 V1248308 RLMH S Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) COG1576 Cluster_355441 V1248311 G Major facilitator superfamily MFS_1 COG0477 Cluster_405441 V1248313 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily COG1368 Cluster_357134 V1248314 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_357135 V1248315 S NA 0YNFS Cluster_449084 V1248316 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_412545 V1248317 SP_0099 S Membrane COG4709 Cluster_357136 V1248320 CSTA T Carbon starvation protein CstA COG1966 Cluster_357137 V1248321 S NA 0YCCW Cluster_543123 V1248322 S NA 0YRPX Cluster_801045 V1248323 K HTH_XRE 0XUC3 Cluster_576527 V1248325 S Sucrose-6F-phosphate phosphohydrolase 0ZK7W Cluster_705453 V1248326 PCP O Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) COG2039 Cluster_724993 V1248327 D, J addiction module toxin, RelE StbE family COG2026 Cluster_892285 V1248329 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Involved in acetate metabolism (By similarity) COG0280 Cluster_475822 V1248330 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_485062 V1248331 PHBA map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map02020 I acetyl-coa acetyltransferase COG0183 Cluster_357138 V1248333 map00230,map01100,map01110 F AICARFT/IMPCHase bienzyme COG0138 Cluster_357139 V1248334 RADC L DNA repair protein (RadC COG2003 Cluster_414417 V1248335 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_357140 V1248337 E Amino acid permease 1C9WB@synNOG Cluster_357141 V1248339 MOD L DNA methylase COG2189 Cluster_449085 V1248340 PFLA O Pyruvate formate-lyase COG1882 Cluster_358799 V1248341 FECA P receptor COG4772 Cluster_358800 V1248342 V Type I restriction-modification system R subunit COG4096 Cluster_368670 V1248344 T response regulator COG0745 Cluster_621679 V1248345 PFLD map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_357142 V1248346 S NA 0XSGQ Cluster_358801 V1248349 S Membrane 0XPM4 Cluster_358802 V1248350 BCELL_1025 L Integrase COG2801 Cluster_360461 V1248351 S NA 11XPU Cluster_433032 V1248352 ECFA1 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_734796 V1248353 GLYQS map00970 J Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) COG0423 Cluster_441024 V1248356 map00473,map00550,map01100 S Pasta domain containing protein 120IY Cluster_360462 V1248358 YQEV J MiaB-like tRNA modifying enzyme COG0621 Cluster_360463 V1248361 YBJI S Hydrolase COG0561 Cluster_431029 V1248362 YWLG S UPF0340 protein COG4475 Cluster_734797 V1248363 VEG S Veg protein COG4466 Cluster_398328 V1248364 FUSA2 J Translation elongation factor COG0480 Cluster_711690 V1248365 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit alpha COG0587 Cluster_463110 V1248367 GAP map00010,map01100,map01110,map01120,map01230,map04066,map05010 G glyceraldehyde-3-phosphate dehydrogenase COG0057 Cluster_473655 V1248368 NYLA map00330,map00360,map00380,map00627,map00643,map01120 J amidase (EC COG0154 Cluster_362035 V1248369 GLGD map00500,map00520,map01100,map01110 M glucose-1-phosphate adenylyltransferase, glgd subunit COG0448 Cluster_509983 V1248370 S NA 0XUSS Cluster_465194 V1248371 BCD map00071,map00280,map00281,map00650,map01100,map01110 I acyl-CoA dehydrogenase COG1960 Cluster_360464 V1248373 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_362036 V1248375 map02010 P ABC transporter COG1122 Cluster_362037 V1248377 map02020 T Sensor histidine kinase 1254H Cluster_653080 V1248378 PANB map00770,map01100,map01110 H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) COG0413 Cluster_614274 V1248379 PANC map00410,map00770,map01100,map01110 H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) COG0414 Cluster_400062 V1248380 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_362038 V1248381 S Inherit from COG: leucine Rich Repeat COG4886 Cluster_405442 V1248382 MURE map00300,map00550 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_380610 V1248383 HLYIII S hemolysin iii COG1272 Cluster_487354 V1248384 S ATP-NAD AcoX kinase COG3199 Cluster_512550 V1248385 SUDEN_0691 S Conserved Protein COG1479 Cluster_621680 V1248387 S NA 0XYB0 Cluster_633017 V1248388 S Chromosome segregation ATPase 11HKQ Cluster_579642 V1248390 MT0459 S Protein of unknown function (DUF664) 11NB2 Cluster_363613 V1248392 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_363614 V1248393 BIOB map00780,map01100 H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) COG0502 Cluster_469398 V1248394 S NA 0YF9C Cluster_683309 V1248395 PEAH map02010 V ABC transporter transmembrane region COG1132 Cluster_586081 V1248397 CRCB D Protein CrcB homolog COG0239 Cluster_389464 V1248401 S copper amine 121X1 Cluster_363616 V1248402 NUOD map00190,map00910,map01100 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) COG0852 Cluster_363617 V1248403 APBE H ApbE family COG1477 Cluster_888170 V1248405 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_372008 V1248406 APPB E, P ABC transporter, permease protein COG0601 Cluster_363618 V1248407 HBD map00071,map00360,map00362,map00650,map00720,map01100,map01120 I Dehydrogenase COG1250 Cluster_758612 V1248409 MSMK map02010 G ABC transporter, ATP-binding protein COG3839 Cluster_621681 V1248410 S NA 122HT Cluster_421567 V1248411 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_365351 V1248412 V ABC transporter COG1132 Cluster_365352 V1248413 LACG map00052,map01100 G Glycosyl hydrolase family 1 COG2723 Cluster_546066 V1248414 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_781240 V1248415 WCHF M Glycosyl transferase (Group 1 0XPWD Cluster_543124 V1248416 CPSE M transferase COG2148 Cluster_375335 V1248417 PCCB map00280,map00630,map00640,map00720,map01100,map01120 I carboxyl transferase domain protein COG4799 Cluster_365353 V1248419 RPE map00030,map00040,map00710,map01100,map01110,map01120,map01230 G ribulose-phosphate 3-epimerase COG0036 Cluster_563825 V1248420 ATPC map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG0355 Cluster_766346 V1248421 L DNA binding domain, excisionase family 11U1N Cluster_363619 V1248423 S NA 0YCCW Cluster_365354 V1248424 MT1789 V abc transporter atp-binding protein COG1131 Cluster_669925 V1248425 RPSJ map03010 J Involved in the binding of tRNA to the ribosomes (By similarity) COG0051 Cluster_365355 V1248427 M Cell wall anchor domain protein 11PS2 Cluster_365356 V1248430 YGCG S of methanol dehydrogenase type COG1512 Cluster_365357 V1248431 map02020 V ABC transporter, permease COG0577 Cluster_610594 V1248434 K RNA Polymerase COG1595 Cluster_718330 V1248435 S NA 0XTN2 Cluster_487356 V1248437 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_412546 V1248438 GPMA map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0588 Cluster_708546 V1248441 YQAJ L phage-type endonuclease COG5377 Cluster_801047 V1248443 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_405443 V1248444 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_368671 V1248445 DPNA L helicase COG4646 Cluster_702355 V1248446 GDHA map00250,map00330,map00910,map01100 E Glutamate dehydrogenase COG0334 Cluster_629165 V1248447 S Phage portal protein COG4695 Cluster_368672 V1248448 SLYD O peptidylprolyl cis-trans isomerase COG1047 Cluster_368673 V1248449 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_370368 V1248452 map00564,map00730 C fad dependent oxidoreductase COG0579 Cluster_368675 V1248455 RFBA map00521,map00523,map01100,map01110 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) COG1209 Cluster_407107 V1248456 HSDS V specificity COG0732 Cluster_441025 V1248457 THIJ S intracellular protease Pfpi family COG0693 Cluster_370369 V1248458 PURF map00230,map00250,map01100,map01110 F glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_370370 V1248460 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_480420 V1248461 M polysaccharide biosynthesis protein COG2244 Cluster_596226 V1248462 CTHE_0148 L Transposase COG3328 Cluster_382392 V1248463 V i restriction-modification system COG0732 Cluster_629166 V1248467 RRMJ J Hemolysin A COG1189 Cluster_859684 V1248469 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_370371 V1248470 M glycosyl transferase group 1 0ZVDW Cluster_797109 V1248471 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_370372 V1248474 S NA 0XP5S Cluster_621682 V1248475 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_573298 V1248478 SCLAV_3941 O Band 7 protein COG0330 Cluster_582885 V1248479 CPMA S 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase COG1691 Cluster_708547 V1248480 S UPF0272 protein COG1641 Cluster_372009 V1248481 LIVG map02010 E ABC transporter COG0411 Cluster_372010 V1248482 K transcriptional regulator laci family COG1609 Cluster_629167 V1248483 RSME S Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) COG1385 Cluster_560841 V1248484 YIGL S Hydrolase COG0561 Cluster_372011 V1248485 MBL D Rod shape-determining protein mreb COG1077 Cluster_373625 V1248487 AMYA map00500,map01100,map04973 G Alpha-amylase COG0366 Cluster_469399 V1248488 GALE map00052,map00520,map01100,map01110 M udp-glucose 4-epimerase COG1087 Cluster_373626 V1248490 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_738140 V1248491 DHAK map00561,map00680,map01100,map01120,map04622 G Dihydroxyacetone kinase COG2376 Cluster_455010 V1248492 YIHO G transporter COG2211 Cluster_373627 V1248493 G 4-alpha-glucanotransferase COG1640 Cluster_699290 V1248495 YLXR K Nucleic-acid-binding protein implicated in transcription termination COG2740 Cluster_692230 V1248497 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_633018 V1248498 HIT map00230,map00240 F, G histidine triad (hIT) protein COG0537 Cluster_551984 V1248499 S -acetyltransferase 11PF0 Cluster_373628 V1248500 CAS3 L CRISPR-Associated Helicase Cas3 COG1203 Cluster_610595 V1248501 RNFA C Electron transport complex COG4657 Cluster_463111 V1248502 NADD map00230,map00760,map01100,map05340 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) COG1057 Cluster_683310 V1248504 map00190,map00680,map01100 C subunit e 0Y1FS Cluster_592749 V1248505 ATPA map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) COG1155 Cluster_417996 V1248510 ARSA map00600,map04142 P Arylsulfatase COG3119 Cluster_375336 V1248513 MGLC map02010 G transporter COG4211 Cluster_375337 V1248514 YLQF K Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) COG1161 Cluster_480421 V1248515 CAPA M Capsule synthesis protein COG2843 Cluster_419778 V1248517 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_375338 V1248518 TELA P Resistance protein COG3853 Cluster_377105 V1248520 LPXH map00540,map01100 S udp-2,3-diacylglucosamine hydrolase COG2908 Cluster_465195 V1248521 TAUC map02010 P binding-protein-dependent transport systems inner membrane Component COG0600 Cluster_487357 V1248522 CARD K Transcriptional regulator (CarD family COG1329 Cluster_603305 V1248523 RPLX map03010 J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) COG0198 Cluster_657222 V1248524 S NA 0XSXN Cluster_452990 V1248527 RPSD map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) COG0522 Cluster_463112 V1248528 GPSA map00564 C NADPH-dependent glycerol-3-phosphate dehydrogenase COG0240 Cluster_596227 V1248529 MRDB map04112 M rod shape-determining protein RodA COG0772 Cluster_705456 V1248530 MRDA map00550 M penicillin-binding protein COG0768 Cluster_377106 V1248531 NTPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_377107 V1248532 YBIT S ABC transporter, ATP-binding protein COG0488 Cluster_696003 V1248534 RIBD map00740,map01100 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) COG1985 Cluster_551985 V1248537 HPPA map00190 C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for COG3808 Cluster_429044 V1248538 LEGAS_1040 L transposase COG2963 Cluster_523239 V1248539 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_377108 V1248540 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_758613 V1248541 S Protein of unknown function (DUF3408) 121RB Cluster_554885 V1248542 D Chromosome partitioning 11HPB Cluster_377109 V1248544 RBSK map00030 G ribokinase COG0524 Cluster_421568 V1248545 S NA 0XWEM Cluster_377110 V1248546 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_378891 V1248551 V abc transporter permease protein COG0577 Cluster_543125 V1248552 NARK P Nitrite extrusion protein COG2223 Cluster_378892 V1248553 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_460993 V1248554 BGLP map02060 G Phosphotransferase System COG1264 Cluster_751625 V1248556 S prevent-host-death family 124KH Cluster_531737 V1248559 RSEP map04112 M Membrane-associated zinc metalloprotease COG0750 Cluster_537418 V1248560 PTS36A map00052,map01100,map02060 G PTS System COG1762 Cluster_378894 V1248561 FUSA2 J Translation elongation factor COG0480 Cluster_692231 V1248562 S Pfam:CarD_TRCF 0ZY1H Cluster_427155 V1248564 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_793132 V1248565 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_687740 V1248566 SIGB K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG1191 Cluster_380611 V1248569 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_439043 V1248571 S hemerythrin hhe cation binding domain protein COG3945 Cluster_396603 V1248573 BL03733 map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_563826 V1248574 N ppe family COG5651 Cluster_380614 V1248577 BCRA map02010 V ABC transporter COG1131 Cluster_797111 V1248578 METH map00270,map00450,map00670,map01100,map01110,map01230 E Methionine synthase COG0646 Cluster_380615 V1248580 PURC map00230,map01100,map01110 F SAICAR synthetase COG0152 Cluster_460994 V1248581 K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) COG1974 Cluster_579643 V1248582 UPPP map00550 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) COG1968 Cluster_382393 V1248583 FEOB P Ferrous iron transport protein b COG0370 Cluster_380616 V1248584 SELB map00450,map00970 J Selenocysteine-specific translation elongation factor COG3276 Cluster_592750 V1248587 S S-layer domain protein 12C8X Cluster_439044 V1248588 map00130,map00770,map01100,map01110 S Methyltransferase 0ZVQZ Cluster_473656 V1248589 USP S CHAP domain protein COG3942 Cluster_382394 V1248593 HLY map04621 S Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation 0XQPX Cluster_382395 V1248594 CITC map02020 C (citrate (pro-3S)-lyase ligase COG3053 Cluster_387753 V1248595 SDHA map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020,map05134 C succinate dehydrogenase, flavoprotein subunit COG1053 Cluster_445014 V1248597 POTD map02010 E ABC transporter COG0687 Cluster_592751 V1248598 RPSK map03010 J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) COG0100 Cluster_382396 V1248600 S NA 11P3R Cluster_836272 V1248602 S NA 0XT4D Cluster_384158 V1248603 BMUL_2968 G N-acylglucosamine 2-epimerase COG2942 Cluster_384159 V1248608 CLPB O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_478018 V1248609 S esterase 1294K Cluster_485063 V1248610 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_384160 V1248612 BL01171 P hemerythrin hhe cation binding domain protein COG2461 Cluster_494677 V1248614 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_429045 V1248615 RFAL map00540,map01100 M O-antigen ligase COG3307 Cluster_661426 V1248616 S Protein of unknown function (DUF464) 0XV7X Cluster_384161 V1248617 LEPB map03060 U Signal peptidase i COG0681 Cluster_384162 V1248618 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_770064 V1248621 K acetyltransferase, (GNAT) family COG0454 Cluster_480422 V1248622 HALSA_0542 L Integrase catalytic subunit COG2801 Cluster_384163 V1248623 ATPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_699291 V1248624 S Conserved domain protein COG4443 Cluster_678763 V1248625 K ParB-like COG1475 Cluster_384164 V1248626 MDLB5 map02010 V Abc transporter COG1132 Cluster_427156 V1248627 NAGB map00520,map01100,map01110 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COG0363 Cluster_385934 V1248630 map02010 V ABC-2 type transporter COG0842 Cluster_385935 V1248632 ALST map02020 E Sodium alanine symporter COG1115 Cluster_385936 V1248633 PORB map00020,map00720,map01100,map01120 C pyruvate ferredoxin flavodoxin oxidoreductase, beta subunit COG1013 Cluster_785335 V1248634 S NA 0ZHU9 Cluster_423425 V1248635 ARGF map00330,map01100,map01110,map01230 E ornithine carbamoyltransferase COG0078 Cluster_385937 V1248636 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_699292 V1248638 FRUA map00051,map01100,map02060 G PTS System COG1762 Cluster_385939 V1248646 S s-layer domain-containing protein 11ZJU Cluster_526151 V1248647 S Protein of unknown function (DUF616) 11SG7 Cluster_504791 V1248650 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_387754 V1248653 YDBC map00051,map00363,map00591,map00625,map00650,map01100,map01120 C aldo keto reductase 16SR0@proNOG Cluster_389465 V1248655 M phosphoglycerol transferase COG1368 Cluster_389466 V1248656 P TonB-dependent receptor Plug 0XNPQ Cluster_423426 V1248658 YHFE E m42 family COG1363 Cluster_389467 V1248659 S ATP GTP-binding protein 0Y0B5 Cluster_408872 V1248660 PHOH T Phoh family COG1702 Cluster_738141 V1248663 S NA 0YIQ4 Cluster_724994 V1248664 S NA 0Z374 Cluster_741559 V1248665 ARSR K Transcriptional regulator, arsR family COG0640 Cluster_405444 V1248666 RLUD J pseudouridine synthase COG0564 Cluster_431030 V1248667 S NA 124BS Cluster_637064 V1248668 L Recombinase COG1961 Cluster_603306 V1248670 SCPA S Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) COG1354 Cluster_721635 V1248671 SPOIVFB S Peptidase M50 COG1994 Cluster_485064 V1248672 NUOE map00190,map00910,map01100 C NADH dehydrogenase (Ubiquinone), 24 kDa subunit COG1905 Cluster_391192 V1248673 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_389468 V1248674 BMPA S basic membrane COG1744 Cluster_389469 V1248675 SOJ D Chromosome Partitioning Protein COG1192 Cluster_678764 V1248676 E, T ABC, transporter COG0834 Cluster_705458 V1248677 GLNP E Abc transporter COG0834 Cluster_389470 V1248679 PRFA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) COG0216 Cluster_809272 V1248680 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_592752 V1248681 DPRA L DNA protecting protein DprA COG0758 Cluster_389471 V1248682 map00052,map00500,map01100 G sucrose-6-phosphate hydrolase COG1621 Cluster_696004 V1248683 COMF S Competence protein COG1040 Cluster_502388 V1248684 S NA 1249W Cluster_389472 V1248686 S NA 101UU Cluster_785336 V1248687 S Domain of unknown function (DUF955) 11SIZ Cluster_427157 V1248689 MAF D MAF-like protein COG0424 Cluster_423427 V1248690 VIRB10 map03070,map05120 U type IV secretion system protein VirB10 COG2948 Cluster_480423 V1248691 AGCS E amino acid carrier protein COG1115 Cluster_391193 V1248692 L Site-specific recombinase, phage integrase family 11F8N Cluster_445015 V1248694 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_485065 V1248695 DACET_0688 L Transposase COG3328 Cluster_403632 V1248696 GLYQS map00970 J Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) COG0423 Cluster_692232 V1248697 RPLW map03010 J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) COG0089 Cluster_391194 V1248698 S YhgE Pip N-terminal domain protein COG1511 Cluster_705459 V1248699 P CBS domain protein COG1253 Cluster_423428 V1248700 S NA 11W5Q Cluster_389473 V1248701 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_589378 V1248702 DGKA map00561,map00564,map01100,map04070 M Diacylglycerol kinase COG0818 Cluster_785337 V1248703 YBEY S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) COG0319 Cluster_797113 V1248704 MNME S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 Cluster_644933 V1248705 K Transcriptional regulator (XRE family COG1396 Cluster_499855 V1248706 MURE map00300,map00550,map01100 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0770 Cluster_391195 V1248708 MURF map00300,map00550,map01100 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) COG0770 Cluster_391196 V1248709 YHFS E pyridoxal phosphate binding 1756R@proNOG Cluster_687741 V1248710 S phage protein 0XQDU Cluster_403633 V1248711 S Copper amine oxidase N-terminal domain 0ZT0J Cluster_391197 V1248712 L helicase COG4646 Cluster_517924 V1248713 SERA map00260,map00680,map01100,map01120,map01230 E Dehydrogenase COG0111 Cluster_391198 V1248715 FTSW map04112 D cell cycle protein, FtsW RodA SpoVE family COG0772 Cluster_391199 V1248716 NHAC-1 map00680 C Na H antiporter COG1757 Cluster_434944 V1248717 RSUA J Pseudouridine synthase COG1187 Cluster_494678 V1248719 S NA 0Z3EY Cluster_391201 V1248721 TAGO M Glycosyl transferase, family 4 COG0472 Cluster_579644 V1248722 VMRA V Mate efflux family protein COG0534 Cluster_669926 V1248723 NTPG map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG1436 Cluster_393008 V1248724 COABC map00770,map01100 H Phosphopantothenoylcysteine decarboxylase COG0452 Cluster_925583 V1248725 BCP O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG1225 Cluster_560842 V1248726 YAAA L UPF0246 protein COG3022 Cluster_393009 V1248727 B, K histone acetyltransferase COG1243 Cluster_715072 V1248728 IUNH map00230,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_809273 V1248729 YVOA K (GntR family) (Transcriptional regulator COG2188 Cluster_702356 V1248730 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_393010 V1248732 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_551986 V1248735 M Membrane 123ZG Cluster_393011 V1248736 YCXD K Transcriptional regulator, GntR family COG1167 Cluster_485066 V1248739 V restriction 11FSE Cluster_429046 V1248740 ADE map00230,map01100 F adenine deaminase COG1001 Cluster_738142 V1248744 L transposase COG1943 Cluster_451051 V1248745 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_394828 V1248746 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_785338 V1248747 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_560843 V1248748 M polysaccharide biosynthesis protein 0XPJ8 Cluster_520487 V1248749 S sialic acid-specific 9-O-acetylesterase 0XQ2Q Cluster_429047 V1248752 L group II intron COG3344 Cluster_512551 V1248753 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_396604 V1248754 LANM V Lanthionine synthetase C family protein COG4403 Cluster_458937 V1248755 SACC map00052,map00500,map01100 G sucrose-6-phosphate hydrolase COG1621 Cluster_396605 V1248756 MELB G melibiose sodium symporter COG2211 Cluster_400063 V1248757 M Glycosyl transferase, family 2 COG1216 Cluster_396606 V1248759 RPLJ map03010 J 50s ribosomal protein L10 COG0244 Cluster_487358 V1248760 map02010 E ABC, transporter COG0834 Cluster_797114 V1248761 PLAV_1224 S NA 0ZTDK Cluster_528920 V1248763 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_396607 V1248764 RIHA map00230,map00240,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_497192 V1248765 YBAK S YbaK ebsC protein COG2606 Cluster_603308 V1248768 S Rubrerythrin 12ADX Cluster_458938 V1248769 SCPA S Segregation and condensation protein COG1354 Cluster_653082 V1248770 FIXA V ABC, transporter COG1131 Cluster_396608 V1248773 K Transcriptional regulator COG2932 Cluster_567016 V1248775 S copper amine 121X1 Cluster_417997 V1248776 SP_0239 S UPF0210 protein COG2848 Cluster_715073 V1248777 SP_2199 S Domain of unknown function DUF77 COG0011 Cluster_398329 V1248779 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_398330 V1248781 MAZG map00230,map00240,map01100 S MazG family COG3956 Cluster_629168 V1248782 ECFT map02010 P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) COG0619 Cluster_748204 V1248783 ECFA2 map02010 P Abc transporter COG1122 Cluster_781242 V1248785 MSRA O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) COG0225 Cluster_398331 V1248788 L Site-specific recombinase COG1961 Cluster_451052 V1248789 P hemerythrin hhe cation binding domain protein COG2461 Cluster_398332 V1248790 GLTA map00020,map00630,map00640,map01100,map01110,map01120,map01210,map01230 C citrate synthase COG0372 Cluster_398333 V1248791 S YitT family COG1284 Cluster_629169 V1248792 PFOR S Membrane COG3641 Cluster_744850 V1248793 P Chromate transport protein COG2059 Cluster_398334 V1248796 PBP2B map00550,map01100 M penicillin-binding protein COG0768 Cluster_400064 V1248797 TRAA map03440 L mobA MobL family protein COG0507 Cluster_398335 V1248798 CCA map03013,map03018 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate COG0617 Cluster_398336 V1248800 SP_0341 S UPF0371 protein COG4868 Cluster_400065 V1248801 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_398337 V1248802 MUTS2 map03430 L muts2 protein COG1193 Cluster_546067 V1248804 YPSC L Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) COG0116 Cluster_731578 V1248806 S lyase containing HEAT-repeat 17QDE@proNOG Cluster_410731 V1248810 S NA 10WKJ Cluster_724995 V1248811 S NA 0Y2WQ Cluster_489699 V1248815 CZCD P cation diffusion facilitator family transporter COG0053 Cluster_523240 V1248816 V ABC transporter transmembrane region 0YGB0 Cluster_478019 V1248817 map00270,map01100 L C-5 cytosine-specific DNA methylase COG0270 Cluster_400066 V1248818 NFO map03410 L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) COG0648 Cluster_400067 V1248821 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_427158 V1248822 S Pfam:DUF567 COG4894 Cluster_433033 V1248823 DPRA L DNA protecting protein DprA COG0758 Cluster_665640 V1248826 TATD L Hydrolase, tatD family COG0084 Cluster_551987 V1248829 RPLU map03010 J This protein binds to 23S rRNA in the presence of protein L20 (By similarity) COG0261 Cluster_439045 V1248830 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_475823 V1248831 S PAP2 superfamily domain protein 126EI Cluster_401843 V1248832 S sporulation and cell division repeat protein 11WNU Cluster_403634 V1248833 NFO map03410 L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) COG0648 Cluster_401844 V1248834 YQFA S UPF0365 protein COG4864 Cluster_401845 V1248836 map05100 G s-layer domain protein 11IBF Cluster_425235 V1248837 V abc transporter permease protein 0XQE2 Cluster_401846 V1248838 O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation (By similarity) COG0544 Cluster_509985 V1248839 YHAM S Metal Dependent Phosphohydrolase COG3481 Cluster_741561 V1248841 RPMA map03010 J 50S ribosomal protein l27 COG0211 Cluster_437006 V1248845 HEMN map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_770066 V1248850 PYRF map00240,map01100 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) COG0284 Cluster_576530 V1248851 PYRE map00240,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_512552 V1248853 G Xylose isomerase domain protein TIM barrel 0ZVDG Cluster_403635 V1248854 S NA 11KFQ Cluster_467286 V1248855 CZCD P cation diffusion facilitator family transporter COG0053 Cluster_458939 V1248856 L resolvase COG1961 Cluster_603309 V1248858 map02020 T regulatoR COG4753 Cluster_708549 V1248859 GATC map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0721 Cluster_520488 V1248860 CASA L crispr-associated protein 0XPA1 Cluster_427159 V1248861 YDCQ D ftsk SpoIIIE family protein COG1674 Cluster_708550 V1248863 V ABC transporter COG1131 Cluster_551988 V1248868 L PP-loop domain protein COG1606 Cluster_403636 V1248871 S SusD family 0YBPW Cluster_744851 V1248876 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_449086 V1248877 S Toxin-antitoxin system, toxin component 0XRRU Cluster_403637 V1248878 S NA 11QVU Cluster_487359 V1248879 P TonB dependent receptor 0YB7D Cluster_416193 V1248883 GPPA map00230 F, P ppx gppa phosphatase COG0248 Cluster_471563 V1248885 SPPA O, U Signal peptide peptidase, SppA COG0616 Cluster_489700 V1248886 TYPA T gtp-binding protein typa COG1217 Cluster_405445 V1248887 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_599729 V1248890 S corrinoid protein 11G0X Cluster_405446 V1248891 S Protein of unknown function (DUF1524) COG3586 Cluster_433034 V1248892 CLFA map05150 M Cell surface-associated protein implicated in virulence. Promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen. Induces formation of bacterial clumps 0Y59N Cluster_657223 V1248893 VANZ V VanZ-like protein COG4767 Cluster_570096 V1248894 AMET_1055 S NA 11I0G Cluster_728282 V1248896 YHHZ S type VI secretion system effector, hcp1 family COG3157 Cluster_405448 V1248897 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_447066 V1248898 YITL S S1 RNA binding domain protein COG2996 Cluster_738143 V1248900 S tonB-dependent Receptor 0YAYV Cluster_692233 V1248901 S NA 11H00 Cluster_405450 V1248902 FEOB P Ferrous iron transport protein b COG0370 Cluster_407108 V1248903 V ABC transporter COG1132 Cluster_427160 V1248905 LACD map00052,map01100 G Aldolase COG3684 Cluster_407109 V1248906 S Membrane 0ZTTH Cluster_407110 V1248907 P Sodium/hydrogen exchanger family COG0475 Cluster_485067 V1248909 map00250,map01054 E aspartate racemase COG1794 Cluster_537419 V1248910 S NA 12C5V Cluster_785341 V1248911 S NA 0Y9YV Cluster_606941 V1248912 S peptidase M23 family 0YFW1 Cluster_499856 V1248915 DEGV S degv family COG1307 Cluster_475824 V1248916 S NA 0ZS1W Cluster_407111 V1248917 VEX1 V ABC transporter, permease COG0577 Cluster_407112 V1248918 map03420,map03430 L helicase COG0210 Cluster_475825 V1248919 E amino acid COG0531 Cluster_408874 V1248920 TAUB P abc transporter COG1116 Cluster_408875 V1248922 BL03504 S phage major capsid protein, HK97 family 0XTEI Cluster_460996 V1248924 PKNB T Serine Threonine protein kinase COG2815 Cluster_408876 V1248928 DCUC C C4-dicarboxylate transporter COG3069 Cluster_471564 V1248930 V ABC transporter COG1132 Cluster_469400 V1248931 GLUD map00250,map00330,map00430,map00471,map00910,map01100,map04964 E Glutamate dehydrogenase COG0334 Cluster_549109 V1248933 RPSL map03010 J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) COG0048 Cluster_408877 V1248934 ASPC map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aminotransferase class I and II COG0436 Cluster_777477 V1248936 S NA 0YWQY Cluster_408878 V1248937 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_497193 V1248940 L Transposase (IS4 family 0ZJC4 Cluster_563827 V1248941 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_840185 V1248942 YLBG S UPF0298 protein COG4471 Cluster_410732 V1248943 COMM O Mg chelatase subunit ChlI COG0606 Cluster_410733 V1248944 PROTEASE map05120 O peptidase COG0826 Cluster_408879 V1248945 BMUR_1332 S Domain of Unknown Function (DUF1599) 0XXR0 Cluster_408881 V1248947 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_770067 V1248949 RNY S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 Cluster_410734 V1248950 YTFP S hi0933 family COG2081 Cluster_410735 V1248951 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_551989 V1248955 map00230 F Adenylate cyclase COG1437 Cluster_820863 V1248956 CP_0141 S metallophosphoesterase COG1768 Cluster_785342 V1248957 GSPF map03070 U type ii secretion system COG1459 Cluster_868007 V1248958 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_456955 V1248959 ADH map00010,map00051,map00071,map00350,map00362,map00363,map00591,map00620,map00621,map00622,map00625,map00626,map00630,map00650,map01100,map01110,map01120 C alcohol dehydrogenase COG1454 Cluster_497194 V1248960 YWDH map00010,map00040,map00053,map00071,map00280,map00281,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00626,map00640,map00903,map01100,map01110,map01120 C Aldehyde dehydrogenase COG1012 Cluster_913359 V1248961 MCSA S Uvrb UvrC protein COG3880 Cluster_482743 V1248962 MCSB map00330 E ATP guanido phosphotransferase COG3869 Cluster_410736 V1248963 RECG map03440 L ATP-dependent DNA helicase RecG COG1200 Cluster_721638 V1248964 RPLD map03010 J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) COG0088 Cluster_412547 V1248965 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G phosphohexokinase COG0205 Cluster_410737 V1248966 V abc transporter permease protein COG0577 Cluster_785343 V1248967 CINA H competence damage-inducible protein COG1546 Cluster_534536 V1248968 G Major Facilitator 0XRAD Cluster_526152 V1248969 L DEAD DEAH box helicase COG1201 Cluster_515255 V1248971 E Binding-protein-dependent transport systems, inner membrane component COG1176 Cluster_412548 V1248975 RNHB map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0164 Cluster_410739 V1248976 PHNP map00440 S Beta-lactamase domain protein COG1235 Cluster_412549 V1248978 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_412550 V1248980 REX K Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) COG2344 Cluster_412551 V1248981 DDH map00300,map01100,map01110,map01230 E Diaminopimelate dehydrogenase 0XPX2 Cluster_412552 V1248982 SP_1233 S NA 11YD9 Cluster_586082 V1248984 S NA 0YGKT Cluster_653084 V1248986 CBIK map00860,map01100 H cobalt chelatase COG4822 Cluster_421569 V1248987 PDXT map00750 H Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) COG0311 Cluster_573299 V1248988 YCFI map02010 V abc transporter COG1132 Cluster_412553 V1248989 VICK map02020 T Histidine kinase 0XNMH Cluster_731579 V1248990 map02010 P Cobalt transport protein COG0619 Cluster_412554 V1248991 SRTC M (sortase) family COG3764 Cluster_637065 V1248992 RPSI map03010 J 30S ribosomal protein S9 COG0103 Cluster_473657 V1248993 CLPL O ATP-dependent Clp protease ATP-binding subunit COG0542 Cluster_414418 V1248994 AGCS E Sodium:alanine symporter family COG1115 Cluster_507374 V1248996 CNA M domain protein 0ZWTG Cluster_520489 V1248997 AATB map02010 E ABC transporter substrate-binding protein COG0834 Cluster_629170 V1248998 APPC map02010 P abc transporter, permease COG1173 Cluster_507375 V1248999 CLVE map02010 S NA 11PT3 Cluster_551990 V1249000 YACL S UPF0231 protein COG3112 Cluster_414419 V1249001 S NA 0ZHU9 Cluster_551991 V1249002 C flavodoxin family COG0716 Cluster_801052 V1249003 P Chromate transport protein COG2059 Cluster_724996 V1249004 S NA 0Y1Q6 Cluster_443026 V1249005 COMEA L Competence protein COG1555 Cluster_469401 V1249006 NLPD M peptidase M23 COG0739 Cluster_687742 V1249010 COAX map00770,map01100 K Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) COG1521 Cluster_805241 V1249011 FOLP map00790,map01100 H dihydropteroate synthase COG0801 Cluster_610597 V1249012 S Phage protein 0Y4MS Cluster_416195 V1249013 ADRA T Diguanylate cyclase 1726A@proNOG Cluster_419779 V1249014 K Transcriptional regulator, TetR family 11S7S Cluster_567017 V1249018 M Inherit from COG: YD repeat protein COG3209 Cluster_416196 V1249019 CORA P magnesium and cobalt transport protein CorA COG0598 Cluster_460997 V1249020 DAGK I Diacylglycerol kinase COG1597 Cluster_416197 V1249021 PRKC T serine threonine protein kinase COG0515 Cluster_755094 V1249023 S sigma 54 modulation protein ribosomal protein S30EA 17A0B@proNOG Cluster_848108 V1249024 L site-specific recombinase, phage integrase family 0ZF8H Cluster_596229 V1249025 L Integrase 0YTFQ Cluster_657224 V1249027 S Helix-turn-helix 0YHHT Cluster_755095 V1249028 S NA 0Z78E Cluster_416198 V1249029 SRTB U sortase, SrtB family COG4509 Cluster_416200 V1249032 S NA COG4926 Cluster_417998 V1249035 PEPA map00480,map01100 E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) COG0260 Cluster_582887 V1249037 RECR map03440 L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) COG0353 Cluster_437007 V1249038 V ABC transporter COG1132 Cluster_762390 V1249039 TRER K GntR family transcriptional regulator COG2188 Cluster_851893 V1249040 BT0173 S NA 0XNSZ Cluster_417999 V1249041 GLTS E Sodium Glutamate Symporter COG0786 Cluster_418000 V1249042 L transposase InsK for insertion sequence COG2801 Cluster_502389 V1249044 PBP2B map00550,map01100 M penicillin-binding protein COG0768 Cluster_418001 V1249045 GLGB map00500,map01100,map01110 G 1,4-alpha-glucan branching enzyme COG0296 Cluster_418002 V1249047 S NA 11NI8 Cluster_708551 V1249048 M Inherit from COG: YD repeat protein COG3209 Cluster_603310 V1249051 V abc transporter atp-binding protein COG1131 Cluster_766349 V1249052 S NA 0Y12I Cluster_618035 V1249053 S NA 17D58@proNOG Cluster_512553 V1249055 S Protein of unknown function (DUF3021) 123B1 Cluster_418003 V1249057 S NA 0Y3G9 Cluster_582888 V1249058 S Iron transport-associated domain protein 0Y3IT Cluster_728283 V1249059 PTSH G phosphocarrier protein (HPr COG1925 Cluster_418004 V1249062 YAET M outer membrane protein assembly complex, YaeT protein COG4775 Cluster_573300 V1249063 RPSI map03010 J 30S ribosomal protein S9 COG0103 Cluster_419780 V1249064 P MgtE intracellular region COG2239 Cluster_805242 V1249066 MPL M UDP-N-acetylmuramate L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase COG0773 Cluster_644934 V1249067 FBP map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map04910 G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 COG0158 Cluster_419781 V1249068 PPDK map00620,map00680,map00710,map00720,map01100,map01120 G pyruvate phosphate dikinase COG0574 Cluster_455012 V1249071 YPFJ S zinc metallopeptidase COG2321 Cluster_625480 V1249072 S Protein of unknown function (DUF1624) COG3503 Cluster_419782 V1249075 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_419783 V1249076 G Domain-Containing protein 11Q0T Cluster_497195 V1249077 FECD map02010 P Permease protein COG0609 Cluster_531738 V1249079 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III alpha subunit COG0587 Cluster_419784 V1249080 YIEG S Xanthine uracil vitamin C permease COG2252 Cluster_586083 V1249082 K RNA polymerase COG1595 Cluster_610598 V1249083 GLPF G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) COG0580 Cluster_715074 V1249084 K helix-turn-helix domain-containing protein 11J2A Cluster_419785 V1249085 F ATP cone domain COG1328 Cluster_449087 V1249086 SRTB M (sortase) family COG3764 Cluster_621686 V1249087 CITD map00020,map01110,map02020 C Covalent carrier of the coenzyme of citrate lyase (By similarity) COG3052 Cluster_419786 V1249088 UVRD map03420,map03430 L ATP-dependent DNA helicase pcra COG0210 Cluster_789357 V1249089 K HTH_XRE 0ZYN1 Cluster_419787 V1249092 DSDA map00260 E d-serine deaminase COG3048 Cluster_419788 V1249093 ATPA map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) COG1155 Cluster_478020 V1249095 PDUO map00860,map01100 S adenosyltransferase COG2096 Cluster_579646 V1249096 THYA map00240,map00670,map01100 F Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) COG0207 Cluster_515256 V1249098 ILVH map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E Acetolactate synthase small subunit COG0440 Cluster_421570 V1249100 WANG_1499 S Transposase 11N3I Cluster_421571 V1249101 S phage Tail Protein 0Z1N7 Cluster_507376 V1249102 ARGS map00970 J Arginyl-tRNA synthetase COG0018 Cluster_419789 V1249103 LACE map00052,map01100,map02060 G pts system, lactose-specific COG1455 Cluster_421572 V1249104 C symporter COG1301 Cluster_773749 V1249105 RLMB map00340,map00350,map00624,map01120 J RNA methyltransferase TrmH family group 3 COG0566 Cluster_629171 V1249106 YACP J Tetracycline resistance protein COG3688 Cluster_421573 V1249107 S Cell surface protein 0ZXQA Cluster_599731 V1249110 map02010 E, T ABC transporter substrate-binding protein COG0834 Cluster_606942 V1249111 SECE map03060,map03070 U Preprotein translocase SecE subunit 0XUXP Cluster_463113 V1249114 COAD map00770,map01100 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) COG0669 Cluster_421574 V1249115 S Ricin-type beta-trefoil lectin domain 124S7 Cluster_421575 V1249116 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_421576 V1249117 SCPA S Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) COG1354 Cluster_471565 V1249120 SMPB O Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) COG0691 Cluster_421577 V1249121 S ExbD TolR family protein 11JMR Cluster_423429 V1249122 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_487360 V1249123 S Copper amine oxidase N-terminal domain 0YD2Q Cluster_421578 V1249124 S NA 1AH6G@sphNOG Cluster_421579 V1249125 CDR P pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_423431 V1249127 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_748205 V1249129 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_463114 V1249130 ATHE_0092 S Uncharacterised protein family (UPF0236) 0XRR3 Cluster_734801 V1249131 YQGX map00620 Q domain protein COG0491 Cluster_485068 V1249133 S Inherit from COG: LOR SDH bifunctional protein conserved domain protein COG1915 Cluster_423433 V1249141 CSTA T carbon starvation protein COG1966 Cluster_494679 V1249142 NRNA J phosphoesterase RecJ domain protein COG0618 Cluster_423435 V1249146 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_423436 V1249147 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily COG1368 Cluster_557792 V1249148 K Transcriptional regulator COG3682 Cluster_423437 V1249149 S NA 0XX4B Cluster_497196 V1249150 S NA 0YC3V Cluster_928998 V1249151 S Pfam:DUF304 0Y8K0 Cluster_423438 V1249152 RIBBA map00740,map01100 H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) COG0807 Cluster_425236 V1249153 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_425237 V1249154 S Exporters of the RND superfamily COG1033 Cluster_423439 V1249155 ASNA map00250,map00460,map00910,map01100,map01110,map01230 E asparagine synthetase A COG2502 Cluster_425238 V1249157 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0587 Cluster_425239 V1249159 NDVA2 V ABC transporter, ATP-binding protein COG1132 Cluster_425240 V1249160 RIBF map00740,map01100 H riboflavin biosynthesis protein ribF COG0196 Cluster_425241 V1249164 S OmpA family 0Z6DZ Cluster_425242 V1249165 PROTEASE map05120 O Peptidase U32 COG0826 Cluster_425243 V1249166 YBBC V conserved protein UCP016719 COG3876 Cluster_637066 V1249167 SEPF S Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) COG1799 Cluster_431033 V1249169 I Lipid kinase, YegS Rv2252 BmrU family COG1597 Cluster_526153 V1249170 TDK map00240,map00983,map01100 F thymidine kinase COG1435 Cluster_896420 V1249171 PPIB O PPIases accelerate the folding of proteins COG0652 Cluster_425244 V1249172 L N-6 DNA Methylase 0XTBT Cluster_425245 V1249173 HTRA map03010 M peptidase S1 and S6, chymotrypsin Hap COG0265 Cluster_427162 V1249174 YFMR S ABC transporter, ATP-binding protein COG0488 Cluster_773751 V1249176 S toxin-antitoxin system, antitoxin component, ribbon-helix-helix 121PE Cluster_489701 V1249178 CSE4 L Crispr-associated protein, cse4 family 0Y6PV Cluster_876058 V1249179 RPLN map03010 J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) COG0093 Cluster_665642 V1249180 RPLX map03010 J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) COG0198 Cluster_427163 V1249181 RGG K Transcriptional regulator COG1396 Cluster_425246 V1249183 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG2247 Cluster_425247 V1249185 T phage Mu protein F like protein COG5585 Cluster_523241 V1249187 S NA 0YZ82 Cluster_543126 V1249188 SUFS map00450,map00730,map01100 E Cysteine desulfurase COG0520 Cluster_456956 V1249189 map02010 P ABC superfamily ATP binding cassette transporter permease protein 0XT24 Cluster_427165 V1249191 S alpha-2-macroglobulin COG2373 Cluster_427166 V1249192 S Prepilin-type N-terminal cleavage methylation domain-containing protein 17I0D@proNOG Cluster_427167 V1249193 BPET1039 S Integrase 0XT4G Cluster_531739 V1249195 HYDA map00240,map00410,map00770,map00983,map01100 F dihydropyrimidinase (EC 3.5.2.2) COG0044 Cluster_661427 V1249197 L Addiction module antitoxin, RelB DinJ family COG3077 Cluster_451055 V1249200 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_702357 V1249201 FTSX map02010 D Part of the ABC transporter FtsEX involved in cellular division (By similarity) COG2177 Cluster_427169 V1249202 GLNA map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG3968 Cluster_427170 V1249203 S Rib/alpha-like repeat 10008 Cluster_429048 V1249204 S Domain of unknown function (DUF1858) 129SC Cluster_427171 V1249205 BT_2352 L Transposase COG3436 Cluster_610599 V1249206 M n-acetylmuramoyl-l-alanine amidase COG5632 Cluster_543127 V1249208 TEH_04440 map00052,map01100,map02060 G PTS system, galactitol-specific IIc component COG3775 Cluster_427172 V1249209 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_431034 V1249211 V Abc transporter COG1132 Cluster_669927 V1249212 MIHF S integration host factor 11UU9 Cluster_429049 V1249213 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_429050 V1249214 S Abortive infection protein 11JRG Cluster_433035 V1249216 S DNA repair protein 0XQPN Cluster_629172 V1249217 S NA 1030P Cluster_429051 V1249219 S domain protein 0XPXI Cluster_451056 V1249221 LACE map00052,map01100,map02060 G pts system, lactose-specific COG1455 Cluster_633022 V1249222 S KAP P-loop COG4928 Cluster_813266 V1249223 S KAP P-loop COG4928 Cluster_429052 V1249224 LEUC map00290,map00660,map01100,map01110,map01210,map01230 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) COG0065 Cluster_560844 V1249225 L Resolvase, N-terminal domain protein COG1961 Cluster_429053 V1249226 NT5E map00230,map00240,map00630,map00760,map01100,map01110 S Hydrolase COG0546 Cluster_429054 V1249228 LEMA S LemA family COG1704 Cluster_509986 V1249229 M Cell wall anchor domain protein 129AF Cluster_429055 V1249230 POLA_2 L DNA polymerase 0XRUF Cluster_429056 V1249231 YUXL E Peptidase, S9A B C family, catalytic domain protein COG1506 Cluster_429057 V1249232 RGPF M Rhamnan synthesis protein F COG3754 Cluster_429058 V1249233 E Family 5 COG0747 Cluster_429059 V1249234 BL05341 S NA 0ZJ54 Cluster_429061 V1249236 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_543128 V1249237 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_921602 V1249238 J radical SAM domain protein COG0820 Cluster_614275 V1249239 J radical SAM domain protein COG0820 Cluster_596230 V1249240 S Prophage pi2 protein 37 11UE0 Cluster_431035 V1249241 L DNA primase helicase 0ZVWQ Cluster_429062 V1249242 S NA 0Y12S Cluster_431036 V1249246 M efflux transporter, rnd family, mfp subunit COG0845 Cluster_431037 V1249247 GLNN map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG3968 Cluster_429063 V1249248 BL03502 O phage portal protein HK97 family COG4695 Cluster_455013 V1249249 BA_0689 E Transporter COG3104 Cluster_431038 V1249250 S NA 11QNK Cluster_429064 V1249251 YGCG S of methanol dehydrogenase type COG1512 Cluster_431039 V1249255 MANN map00051,map00052,map00520,map01100,map02060 G PTS system mannose fructose sorbose family transporter subunit IID COG3716 Cluster_431040 V1249256 T ATPase histidine kinase DNA gyrase B HSP90 domain protein 0XNMH Cluster_848109 V1249257 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_851894 V1249259 ASP S Alkaline-shock protein COG1302 Cluster_699295 V1249260 UGPE map02010 P ABC transporter (Permease COG0395 Cluster_702358 V1249261 UGPA map02010 G Binding-protein-dependent transport systems inner membrane component COG1175 Cluster_431041 V1249262 FHUB map02010 P ABC transporter, permease COG0609 Cluster_431042 V1249263 LYSA2 M Glyco_25 COG3757 Cluster_618036 V1249264 PTH J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) COG0193 Cluster_789358 V1249265 PRS map00030,map00230,map01100,map01110,map01120,map01230 E, F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_469402 V1249266 INFC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) COG0290 Cluster_762391 V1249267 GLTD C oxidoreductase FAD NAD(P)-binding domain protein COG0543 Cluster_669928 V1249269 RIBU S Membrane COG3601 Cluster_551992 V1249270 ARSB P arsenical pump membrane protein COG1055 Cluster_888175 V1249271 ARSC P arsenate reductase COG1393 Cluster_431043 V1249272 HTPG map04141,map04151,map04612,map04621,map04626,map04914,map04915,map05200,map05215 O Molecular chaperone. Has ATPase activity (By similarity) COG0326 Cluster_455014 V1249274 BMUL_3652 V Abortive infection bacteriophage resistance protein COG4823 Cluster_431044 V1249275 ZNUA map02010 P transporter substrate-binding protein COG0803 Cluster_433037 V1249276 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_433038 V1249280 D domain protein 0XTIC Cluster_433040 V1249282 S NA 101UU Cluster_433041 V1249283 F Amidohydrolase family COG0402 Cluster_497197 V1249284 S Conserved Protein COG3538 Cluster_434945 V1249285 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_433042 V1249288 S NA 125HN Cluster_433043 V1249289 THYA map00240,map00670,map01100 F Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) COG0207 Cluster_637067 V1249290 SPR M NlpC p60 family protein COG0791 Cluster_540217 V1249292 YLBM S UPF0348 protein COG1323 Cluster_460999 V1249293 S Hydrolase COG0561 Cluster_744852 V1249295 S Protein of unknown function (DUF3021) 0Y7Z2 Cluster_817022 V1249297 map00010,map00030,map00051,map00052,map00680,map00710,map01100,map01110,map01120,map01230 G aldolase COG0191 Cluster_482744 V1249298 SPPA O, U Signal peptide peptidase, SppA COG0616 Cluster_433044 V1249299 P receptor COG1629 Cluster_433045 V1249300 S ABC transporter solute-binding protein COG4134 Cluster_433046 V1249302 K Transcriptional regulator COG1414 Cluster_801054 V1249305 K HTH_XRE 0XUC3 Cluster_433047 V1249306 HLYX P CBS domain protein COG1253 Cluster_478021 V1249308 AGCS E amino acid carrier protein COG1115 Cluster_433048 V1249309 DEAD map03018 L dead deah box COG0513 Cluster_766351 V1249310 K GntR Family Transcriptional Regulator COG2188 Cluster_913362 V1249311 CELB map02060 G iic component COG1455 Cluster_434946 V1249314 L Dna topoisomerase COG0550 Cluster_434947 V1249315 AROE map00400,map01100,map01110,map01230 E shikimate COG0169 Cluster_434948 V1249317 EAEH map05100 S K13735 adhesin invasin 16SKU@proNOG Cluster_748207 V1249319 KTRB P Potassium uptake protein COG0168 Cluster_434949 V1249320 GLPB map00564 E anaerobic glycerol-3-phosphate dehydrogenase, subunit B COG3075 Cluster_467287 V1249324 TPX O Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) COG2077 Cluster_540218 V1249325 S Signal transducer 0ZVDY Cluster_434950 V1249326 DPPD E, P ABC transporter COG0444 Cluster_434951 V1249328 C symporter COG1301 Cluster_625482 V1249330 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_618037 V1249331 METQ map02010 P lipoprotein COG1464 Cluster_449088 V1249332 OPPA E ABC transporter COG0747 Cluster_437008 V1249333 S Inherit from COG: domain protein COG1511 Cluster_437009 V1249334 N repeat protein 11QCF Cluster_437010 V1249336 APEB E M18 family aminopeptidase COG1362 Cluster_531740 V1249337 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_437011 V1249339 S Amino terminal protease 11T6A Cluster_884261 V1249340 YBAN S Membrane COG2832 Cluster_458940 V1249342 MUTS2 L DNA mismatch repair protein COG0249 Cluster_458941 V1249343 S s-layer domain-containing protein 122G9 Cluster_549110 V1249344 M peptidase M23 COG0739 Cluster_437012 V1249346 TRPE map00400,map01100,map01110,map01230 E, H Anthranilate synthase component I, N terminal region COG0147 Cluster_437013 V1249347 AHPF O Alkyl hydroperoxide reductase COG3634 Cluster_437014 V1249348 M Inherit from COG: filamentous hemagglutinin family outer membrane protein COG3209 Cluster_809276 V1249349 RPSM map03010 J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits COG0099 Cluster_461000 V1249350 ATP2C1 P p-type ATPase COG0474 Cluster_437015 V1249351 E Peptidase dimerisation domain COG1473 Cluster_439046 V1249354 SRFJ map00511,map00600,map01100,map04142 G hydrolase family 30 COG5520 Cluster_567018 V1249355 METQ map02010 P (Lipo)protein COG1464 Cluster_439047 V1249356 S peptidase, S41 11FNN Cluster_567019 V1249357 L Integrase core domain protein COG2801 Cluster_669929 V1249360 APPB P Binding-protein-dependent transport systems, inner membrane component COG0601 Cluster_755097 V1249361 BA_0233 P abc transporter, permease COG1173 Cluster_665643 V1249362 NOX map00190 P pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_445016 V1249364 PITA P phosphate transporter COG0306 Cluster_439048 V1249366 LACZ map00052,map00511,map00600,map01100 G Glycoside hydrolase family 2 TIM barrel COG3250 Cluster_443027 V1249367 HFLX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COG2262 Cluster_546068 V1249370 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_606944 V1249373 S X-Pro dipeptidyl-peptidase (S15 family) 0ZJEE Cluster_560845 V1249376 COBD map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01230 E decarboxylase COG0079 Cluster_744853 V1249377 map02020 T Histidine kinase 11JQW Cluster_687744 V1249378 VRAR map02020 T response regulator COG2197 Cluster_441029 V1249379 S prophage protein 0ZR61 Cluster_582892 V1249380 MALD map02010 P ABC transporter, permease COG3833 Cluster_603312 V1249384 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_441030 V1249385 S Methyltransferase 11REP Cluster_441031 V1249388 YUFP S (ABC) transporter COG4603 Cluster_813267 V1249389 S NA 0Y5YJ Cluster_439050 V1249394 L Inherit from COG: Resolvase COG1961 Cluster_480424 V1249395 S NA 0Z20Q Cluster_441033 V1249396 ISPE map00900,map01100,map01110 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COG1947 Cluster_674317 V1249397 CADD P cadmium resistance COG4300 Cluster_441034 V1249398 NRDB map00230,map00240,map00480,map01100,map04115 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_526154 V1249400 S Signal transduction histidine kinase, lyts 11GMZ Cluster_461001 V1249401 TREB map00010,map00500,map00520,map02060 G PTS system trehalose-specific transporter subunit IIBC COG1264 Cluster_738144 V1249402 SGBE map00040,map00053,map01100,map01120 G L-ribulose-5-phosphate 4-epimerase COG0235 Cluster_718332 V1249403 SGBE map00040,map00053,map01100,map01120 G L-ribulose-5-phosphate 4-epimerase COG0235 Cluster_744854 V1249405 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_579647 V1249406 PUCG map00250,map00260,map00630,map00680,map01100,map01110,map01120,map04146 E Aminotransferase COG0075 Cluster_443028 V1249407 MPRF map05150 J Membrane COG2898 Cluster_537420 V1249408 MURG map00550,map01100,map04112 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) COG0707 Cluster_797116 V1249409 K TRANSCRIPTIONAl REGULATOR GntR family COG1725 Cluster_443030 V1249411 K TRANSCRIPTIONal 11ZCE Cluster_913364 V1249412 NHAA map00680 P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) COG3004 Cluster_653086 V1249413 YTEJ S rdd domain containing protein COG1714 Cluster_563828 V1249414 M hydrolase, family 25 COG3757 Cluster_935233 V1249415 YCCF S Membrane COG3304 Cluster_653087 V1249416 S Protein of unknown function DUF111 COG1641 Cluster_443031 V1249418 SRTD M Sortase family COG3764 Cluster_621688 V1249419 map00010,map00030,map00051,map00052,map00680,map00710,map01100,map01110,map01120,map01230 G Aldolase COG0191 Cluster_465198 V1249420 YHAN S domain protein COG4717 Cluster_718334 V1249423 DRAG O ADP-ribosylation crystallin J1 COG1397 Cluster_443032 V1249424 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_494680 V1249427 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_683312 V1249429 YCHF J gtp-binding protein COG0012 Cluster_445017 V1249430 LKTB3 V ABC transporter, ATP-binding protein COG2274 Cluster_445018 V1249431 S NA 100W0 Cluster_492194 V1249432 PHOH T Phoh family COG1702 Cluster_653088 V1249433 MGTE P magnesium transporter COG2239 Cluster_711691 V1249434 S NA 11MP2 Cluster_621689 V1249435 G Major Facilitator 0XRAD Cluster_445019 V1249436 YJGR S ATP-binding protein COG0433 Cluster_509988 V1249437 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_443034 V1249438 GLGB map00500,map01100,map01110,map04973 G Aamy COG3979 Cluster_445020 V1249440 S NA 11NI8 Cluster_443035 V1249442 map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_452992 V1249443 S Domain of unknown function (DUF1896) 0YBI2 Cluster_445021 V1249444 ATPA map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_528921 V1249446 NIKR K Transcriptional regulator (By similarity) COG0864 Cluster_445022 V1249448 CYDC map02010 V Abc transporter COG1132 Cluster_445023 V1249449 CODB F permease for cytosine purines, uracil, thiamine, allantoin COG1457 Cluster_445024 V1249451 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_917700 V1249452 ARGF map00330,map01100,map01110,map01230 E ornithine carbamoyltransferase COG0078 Cluster_614276 V1249453 ARCC map00230,map00330,map00910,map01120 E carbamate kinase COG0549 Cluster_461002 V1249455 RRGB M Lpxtg-motif cell wall anchor domain protein 0XSEP Cluster_445025 V1249456 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_540219 V1249458 QUEG C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) COG1600 Cluster_447068 V1249460 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_445026 V1249462 NRDB map00230,map00240,map00480,map01100,map04115 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_485069 V1249463 map02020 E amino acid carrier protein COG1115 Cluster_461003 V1249464 K Peptidase S24-like protein COG2932 Cluster_526155 V1249465 RUVC map03440 L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) COG0817 Cluster_715075 V1249466 COAD map00770,map01100 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) COG0669 Cluster_447069 V1249467 TNP3508A L Transposase COG3328 Cluster_499858 V1249468 RPSP map03010 J 30s ribosomal protein S16 COG0228 Cluster_478022 V1249472 CSE4 L Crispr-associated protein, cse4 family 0Y6PV Cluster_447070 V1249474 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_859688 V1249475 S NA 121S9 Cluster_447072 V1249477 S NA 0XRT7 Cluster_447073 V1249478 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_487362 V1249479 S Major capsid protein 10Y9G Cluster_523242 V1249480 RPLV map03010 J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) COG0091 Cluster_523243 V1249481 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_447074 V1249483 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_781243 V1249489 RNFE C Electron transport complex COG4660 Cluster_596231 V1249491 COMEB map00240,map01100 F deaminase COG2131 Cluster_840186 V1249492 RNHA map03030 S ribonuclease COG3341 Cluster_674318 V1249493 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_864015 V1249494 OORD map00020,map00720,map01100,map01120 C 2-oxoglutarate-acceptor oxidoreductase subunit oord COG1146 Cluster_665644 V1249497 OPPF map02010 E (ABC) transporter COG4608 Cluster_447075 V1249499 T Histidine kinase COG0642 Cluster_447076 V1249500 SILP P copper-exporting ATPase COG2217 Cluster_678767 V1249502 S NA 180G3@proNOG Cluster_447077 V1249505 S NA 11NI8 Cluster_449089 V1249508 HOM E saf domain-containing protein COG4091 Cluster_471566 V1249509 GRAR map02020 T response regulator COG0745 Cluster_824836 V1249510 map02010 P ABC transporter COG1122 Cluster_805246 V1249511 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_876059 V1249512 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_449090 V1249513 YQFO S dinuclear metal center protein, YbgI family COG0327 Cluster_449091 V1249514 PITRM1 O peptidase COG1026 Cluster_773752 V1249515 SP_0677 S Bacterial protein of unknown function (DUF910) COG4483 Cluster_543129 V1249517 S NA 0XR5V Cluster_494681 V1249518 HSLO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) COG1281 Cluster_449092 V1249522 S NA 0Y8K6 Cluster_455015 V1249523 F ATP cone domain COG1328 Cluster_461004 V1249525 COBO map00860,map01100 H Cob-I-yrinic acid a,c-diamide adenosyltransferase COG2109 Cluster_683313 V1249526 HFLX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COG2262 Cluster_734802 V1249527 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_449093 V1249529 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_449094 V1249533 map02010 P extracellular solute-binding protein COG1840 Cluster_449095 V1249534 UVRD2 map03420,map03430 L helicase COG0210 Cluster_449096 V1249535 TRAD U Conjugative transfer protein COG3505 Cluster_451057 V1249537 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_449097 V1249538 map00550,map01100 M glycosyl transferase, family 51 COG0744 Cluster_451059 V1249540 M NA 11FBZ Cluster_549111 V1249541 map00550 M Penicillin-binding Protein dimerisation domain COG0772 Cluster_683314 V1249542 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_748208 V1249543 SUFB O SufB sufD domain protein COG0719 Cluster_451060 V1249544 FOPA M ompA family 10ZT3 Cluster_467288 V1249545 V Eco57I restriction endonuclease COG0827 Cluster_451061 V1249546 S repeat protein 11IAG Cluster_687747 V1249548 L Excinuclease ABC C subunit domain protein COG2827 Cluster_449098 V1249550 G Ricin-type beta-trefoil lectin domain COG3507 Cluster_570098 V1249551 S RelA SpoT domain protein COG2357 Cluster_451063 V1249553 LSA_01360 L transposase COG0675 Cluster_451064 V1249554 I Diacylglycerol kinase catalytic domain COG1597 Cluster_451067 V1249559 ENC_21990 map00473,map01100 K LacI family transcriptional regulator COG1609 Cluster_512554 V1249563 map00564 C NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus COG0240 Cluster_451069 V1249564 S NA 0YH2T Cluster_471567 V1249565 O DnaJ domain protein COG0484 Cluster_546069 V1249566 FTSQ map04112 S domain protein, FtsQ-type 11WVZ Cluster_451070 V1249569 S Inherit from COG: LOR SDH bifunctional protein conserved domain protein COG1915 Cluster_614277 V1249571 C radical SAM domain protein COG1032 Cluster_451071 V1249574 SLGD_00064 map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_603314 V1249575 ASP S Alkaline-shock protein COG1302 Cluster_781244 V1249576 YEHE S Protein of unknown function (DUF2574) 17MES@proNOG Cluster_567021 V1249577 Q methyltransferase, type 11 COG0500 Cluster_452994 V1249578 XDHA map00230,map01100,map01120 C Xanthine dehydrogenase COG1529 Cluster_614278 V1249579 TRAL S NA 11MPG Cluster_451072 V1249580 M phosphoglycerol transferase alkaline phosphatase superfamily protein COG1368 Cluster_451073 V1249581 S NA 11KMZ Cluster_452995 V1249582 SECA2 map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_451074 V1249583 V Abc transporter COG1132 Cluster_451075 V1249584 ETFA map00910 C Electron transfer flavoprotein COG2025 Cluster_781245 V1249586 S PemK-like protein COG3692 Cluster_576532 V1249589 map02010 P ABC transporter COG0395 Cluster_452996 V1249590 U, W Pfam:YadA COG5295 Cluster_715076 V1249591 L NA 1024P Cluster_452998 V1249594 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily COG1368 Cluster_452999 V1249595 CYDC map02010 V ABC transporter, ATP-binding protein COG1132 Cluster_705462 V1249597 map02010 V Abc transporter COG1132 Cluster_621690 V1249598 MAZF T Toxic component of a toxin-antitoxin (TA) module (By similarity) COG2337 Cluster_456957 V1249600 FTSK D cell division protein FtsK COG1674 Cluster_453001 V1249601 SELD map00450,map01100 E Synthesizes selenophosphate from selenide and ATP (By similarity) COG0709 Cluster_453002 V1249602 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_455016 V1249603 WEFI M Glycosyl transferase (Group 1 10DZH Cluster_455017 V1249605 FEOB P Ferrous iron transport protein b COG0370 Cluster_453003 V1249606 S NA 0XNWW Cluster_453004 V1249608 KIPA E Allophanate hydrolase subunit 2 COG1984 Cluster_540220 V1249609 S NA 11HU9 Cluster_455018 V1249610 TRMJ J RNA methyltransferase TrmH family, group 1 COG0565 Cluster_455019 V1249611 BMUL_0473 S ABC transporter, permease COG4120 Cluster_455020 V1249615 S inner membrane protein DUF1819 0Y422 Cluster_475826 V1249617 NFED O nodulation efficiency protein D COG1030 Cluster_482746 V1249618 BTUS_1671 L Pfam:Phage_integr_N COG4974 Cluster_456958 V1249619 RUVC map03440 L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) COG0817 Cluster_494682 V1249621 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_455021 V1249624 map02010 V ABC transporter COG1132 Cluster_455022 V1249625 MUTE map00660,map01100 E Methylaspartate mutase, E subunit COG4865 Cluster_455023 V1249627 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_573303 V1249629 NRDI F Probably involved in ribonucleotide reductase function (By similarity) COG1780 Cluster_618038 V1249630 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_475827 V1249631 S NA 0YKNH Cluster_644935 V1249634 YITW O fes assembly suf system protein COG2151 Cluster_485070 V1249635 U Conjugal transfer protein 10082 Cluster_456960 V1249642 YBHK S UPF0052 protein COG0391 Cluster_494683 V1249643 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_523244 V1249644 S NA 0YSGI Cluster_836278 V1249645 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_766352 V1249646 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_573304 V1249647 APPA E Extracellular solute-binding protein, family 5 COG0747 Cluster_456961 V1249648 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_455025 V1249649 M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_921604 V1249650 ENTB Q Isochorismatase, hydrolase 11I3F Cluster_629174 V1249651 PHNA map00440,map01120 P Alkylphosphonate utilization operon protein PhnA COG2824 Cluster_456962 V1249653 S NA 102QB Cluster_492195 V1249654 S NA 0YCIZ Cluster_661428 V1249655 HYDE map00780,map01100 H radical SAM domain protein COG0502 Cluster_456963 V1249656 SP_0239 S UPF0210 protein COG2848 Cluster_748209 V1249657 K RNA polymerase sigma factor, sigma-70 family 0Y4P1 Cluster_696007 V1249658 S Helix-turn-helix 0YAU0 Cluster_528922 V1249659 XYLE map04113 G transporter 16TAE@proNOG Cluster_469404 V1249660 V Mate efflux family protein COG0534 Cluster_579648 V1249662 NPDA map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_711692 V1249663 K regulatoR 11M38 Cluster_669931 V1249664 RPLT map03010 J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) COG0292 Cluster_456964 V1249667 S NA 11NI8 Cluster_456965 V1249668 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_573305 V1249674 E, P ABC superfamily ATP binding cassette transporter ABC protein COG0444 Cluster_859690 V1249675 SCLAV_4418 L decarboxylase COG1611 Cluster_669932 V1249676 S Inherit from NOG: S-layer protein 0ZUVU Cluster_458942 V1249677 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_801057 V1249680 NPDA map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_473658 V1249683 S NA 0XRT1 Cluster_458943 V1249685 LCD map00270,map00450,map00920,map01100,map01110,map01230 E Aminotransferase class I and II COG1168 Cluster_669933 V1249686 T crp fnr family transcriptional regulator COG0664 Cluster_586086 V1249687 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0470 Cluster_610600 V1249690 BMUL_3003 S Membrane COG3619 Cluster_696008 V1249691 VC1767 S Protein of unknown function DUF262 COG1479 Cluster_456966 V1249692 APBE H ApbE family COG1477 Cluster_512555 V1249693 T Histidine kinase COG0642 Cluster_458944 V1249694 S phage tail tape measure protein COG5412 Cluster_515257 V1249696 M Outer membrane protein, OMP85 family 0XNPU Cluster_633023 V1249697 S NA 102FF Cluster_699296 V1249698 RARA L recombination factor protein RarA COG2256 Cluster_621691 V1249700 S tetratricopeptide 0XQVJ Cluster_458945 V1249701 S NA 0XR9X Cluster_683315 V1249702 LTRA L reverse transcriptase COG3344 Cluster_560846 V1249703 S NA 0Y4DT Cluster_458946 V1249704 S smc domain-containing protein 0XTF4 Cluster_699297 V1249705 NHAC-1 map00680 C Na H antiporter COG1757 Cluster_497198 V1249706 P transporter COG0471 Cluster_531741 V1249709 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_458948 V1249710 E Dipeptidase COG4690 Cluster_692236 V1249711 S NA 11MKU Cluster_458949 V1249712 LTRA L reverse transcriptase COG3344 Cluster_458950 V1249713 S TIGR02453 family COG5587 Cluster_711695 V1249715 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_458951 V1249716 YPWA E carboxy-peptidase COG2317 Cluster_801058 V1249718 PURE map00230,map01100,map01110 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) COG0041 Cluster_748210 V1249719 T serine threonine protein kinase COG0515 Cluster_596232 V1249722 S NA 0ZHU9 Cluster_461005 V1249725 ELFC map05133 M outer membrane usher protein COG3188 Cluster_461006 V1249728 S PAP2 superfamily domain protein 11HHM Cluster_494685 V1249729 ZWF map00030,map00480,map01100,map01110,map01120 G glucose-6-phosphate 1-dehydrogenase COG0364 Cluster_458952 V1249730 PNCA map00760,map01100 Q nicotinamidase COG1335 Cluster_669934 V1249731 S NA 1875K@proNOG Cluster_461007 V1249732 YGEY map00330,map01100,map01110,map01210,map01230 E M20 DapE family protein YgeY COG0624 Cluster_461008 V1249733 S Protein of unknown function (DUF1524) COG1479 Cluster_770072 V1249734 SDPI S Membrane COG5658 Cluster_721640 V1249735 K Transcriptional regulator, arsr family COG0640 Cluster_473659 V1249736 K Transcriptional regulator, TetR family 11JD6 Cluster_461009 V1249737 HSDS V type I restriction-modification system COG0732 Cluster_458953 V1249738 S Major capsid protein 10Y9G Cluster_625483 V1249739 BPR_I0156 L transposase COG1943 Cluster_461010 V1249740 CSHA map03018 L atp-dependent rna helicase COG0513 Cluster_463116 V1249743 NTPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_705463 V1249744 S DNA-binding protein 0YGF9 Cluster_738145 V1249748 INFA J however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) COG0361 Cluster_461011 V1249749 ALL2459 S ATP GTP Binding Protein 0XQ3U Cluster_523245 V1249750 S Bacterial SH3 domain 0ZPAA Cluster_461012 V1249752 L transposase, IS605 OrfB COG0675 Cluster_789359 V1249753 FRVA G PTS system, fructose-specific, IIA component COG1762 Cluster_678769 V1249755 V FtsX-like permease family 0ZW5X Cluster_489704 V1249758 I Diacylglycerol kinase COG1597 Cluster_534538 V1249759 ATPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_461013 V1249760 map00260,map00270,map00300,map01100,map01110,map01120,map01230 E Homoserine dehydrogenase COG0527 Cluster_463117 V1249761 YPO4104 map00650,map01100 S reductase (By COG3007 Cluster_461014 V1249762 S NA 0ZT45 Cluster_758616 V1249763 YOCS S Bile acid COG0385 Cluster_770073 V1249764 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_461015 V1249765 RRGB M Lpxtg-motif cell wall anchor domain protein 0XSEP Cluster_461016 V1249766 SUN J ribosomal RNA small subunit methyltransferase COG0144 Cluster_637068 V1249771 UPP map00240,map01100 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) COG0035 Cluster_463118 V1249773 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_463119 V1249774 YCLM map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Aspartokinase COG0527 Cluster_463120 V1249776 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_463121 V1249777 C NADH flavin oxidoreductase NADH oxidase COG1902 Cluster_665645 V1249778 S NA 11FZQ Cluster_848111 V1249779 K, T MT-A70 family COG4725 Cluster_855667 V1249780 PTP T protein tyrosine serine phosphatase COG2365 Cluster_758617 V1249787 MTNA map00270,map01100 J Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) COG0182 Cluster_777480 V1249788 MTNP map00270,map01100 F Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) COG0005 Cluster_781246 V1249790 S NA 0ZHU9 Cluster_463122 V1249791 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_913368 V1249792 S Uncharacterized BCR, YitT family COG1284 COG1284 Cluster_463123 V1249794 BDHA map00051,map00363,map00591,map00625,map00650,map01100,map01120 C alcohol dehydrogenase COG1979 Cluster_625484 V1249795 YDED E, G Membrane COG0697 Cluster_463124 V1249796 DGOT G Major Facilitator 0XR3C Cluster_463125 V1249797 OCAR_5891 map00020,map00720,map01100,map01110,map01120,map05200,map05211 P iron permease COG0672 Cluster_537421 V1249798 S NA 101MB Cluster_557793 V1249799 L 5'-3' exonuclease COG0749 Cluster_714254 V1024804 PAAK map00360,map01120,map05132 C phenylacetate-CoA oxygenase reductase PaaK subunit COG1018 Cluster_605951 V1024805 BMUL_0226 K Tetr family transcriptional regulator 178FV@proNOG Cluster_695156 V1024806 S Membrane COG1284 Cluster_378481 V1024807 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_380185 V1024816 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_434467 V1024817 FLGI map02040 N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) COG1706 Cluster_595277 V1024818 PGLB M Sugar transferase COG2148 Cluster_536678 V1024819 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_545252 V1024821 S NA 11EMI Cluster_401411 V1024822 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_484474 V1024825 FADD32 I, Q amp-dependent synthetase and ligase COG0318 Cluster_754180 V1024827 ATPE map00190,map00195,map01100 C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) COG0636 Cluster_668878 V1024832 PBP2B M penicillin-binding protein COG0768 Cluster_761357 V1024833 S NA 122DJ Cluster_578773 V1024834 FATC map02010 P permease protein COG4605 Cluster_605952 V1024835 YIJD S Membrane 17B8Z@proNOG Cluster_380186 V1024838 M Peptidase family S41 COG0793 Cluster_380187 V1024840 P TonB-dependent receptor Plug 0XNPQ Cluster_545253 V1024841 L NA 1004T Cluster_858490 V1024847 S NA 0ZHU9 Cluster_831331 V1024848 S NA 0ZHU9 Cluster_548294 V1024852 T universal stress protein COG0589 Cluster_424789 V1024857 S NA 0XV8P Cluster_519831 V1024861 MYCA S Myosin-Cross-Reactive Antigen COG4716 Cluster_381964 V1024862 LCFB map00071,map00130,map01100,map01110,map03320,map04146,map04920 I, Q o-succinylbenzoate--CoA ligase COG0318 Cluster_525425 V1024867 FADD35 map00071,map01100,map03320,map04146,map04920 Q AMP-binding enzyme COG0318 Cluster_383751 V1024870 GRDE S reductase 0XPPI Cluster_496555 V1024871 S NA 0ZHU9 Cluster_588491 V1024879 S NA 11FVN Cluster_730743 V1024882 S7335_1001 C Aldo keto reductase COG0667 Cluster_733943 V1024883 K Transcriptional regulator 11NY0 Cluster_383754 V1024885 P tonB-dependent Receptor 0XNUH Cluster_647926 V1024886 S NA 17TX6@proNOG Cluster_660330 V1024887 K RNA Polymerase COG1595 Cluster_635927 V1024888 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_383755 V1024891 S phage portal protein, SPP1 0ZZDC Cluster_843181 V1024892 S Plasmid stabilization system 17G8E@proNOG Cluster_509309 V1024893 S NA 0Z59M Cluster_385512 V1024897 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_385513 V1024898 S NA COG4926 Cluster_385515 V1024903 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_385516 V1024912 NASA map00630,map00680,map00910,map01100,map01120 C Nitrate reductase COG0243 Cluster_385517 V1024913 CAFA map03018 J ribonuclease COG1530 Cluster_506679 V1024914 MGSA map00620 G methylglyoxal synthase COG1803 Cluster_504195 V1024916 MTSC map02010,map02020 P ABC transporter COG1108 Cluster_533767 V1024920 RPIC_1670 M RND efflux system, outer membrane lipoprotein, NodT COG1538 Cluster_387332 V1024924 YTQA S Radical SAM Protein COG1242 Cluster_387333 V1024926 ARBF map00010,map00500,map00520,map02060 G PTS system beta-glucoside-specific transporter subunit IIABC COG2190 Cluster_387334 V1024929 TRXB map00240,map00450 O Thioredoxin reductase COG0492 Cluster_652017 V1024930 S NA 11IJN Cluster_387336 V1024933 S Protein of unknown function DUF262 0ZMV0 Cluster_887172 V1024936 NSPC map00330 E Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) COG0019 Cluster_394357 V1024937 S thiJ PfpI domain-containing protein COG0693 Cluster_387337 V1024938 NUCA map04210 F DNA RNA NON-specific endonuclease COG1864 Cluster_454562 V1024940 LIVK map02010 E branched-chain amino acid ABC transporter COG0683 Cluster_389071 V1024942 L reverse transcriptase COG3344 Cluster_765319 V1024943 CCDA O cytochrome C biogenesis COG0785 Cluster_591863 V1024944 MT1293 map00350,map00362,map00627,map00642,map00903,map01120 I Acyl-transferase COG1835 Cluster_720793 V1024945 map00362,map01100,map01120 Q decarboxylase COG0599 Cluster_701624 V1024946 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_585229 V1024949 S NA 11FFJ Cluster_588493 V1024951 XAPA map00230,map00240,map00270,map00760,map01100,map01110 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) COG0005 Cluster_673151 V1024952 map05132 M repeat protein COG3209 Cluster_389072 V1024953 C Thiol oxidoreductase COG3488 Cluster_389074 V1024955 FBA map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01230 G Fructose-1,6-bisphosphate aldolase, class II COG0191 Cluster_389076 V1024970 M serine-type D-Ala-D-Ala carboxypeptidase COG1686 Cluster_389077 V1024973 S Patatin family COG3621 Cluster_389078 V1024974 S NA 177AF@proNOG Cluster_390816 V1024977 DPRE1 C FAD linked oxidase domain protein COG0277 Cluster_390817 V1024978 map00340,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034 E decarboxylase COG0076 Cluster_390818 V1024979 MESO_0046 S NA 16TX2@proNOG Cluster_730744 V1024983 CLPS O Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) COG2127 Cluster_390819 V1024984 OCAR_7462 map00270,map00450,map01100,map01110,map01230 E Methionine synthase COG0620 Cluster_390820 V1024985 YDIJ map00620,map00630,map01100,map01110,map01120 C Oxidoreductase COG0277 Cluster_442556 V1024986 S NA 0XS0Q Cluster_390821 V1024989 TRMB C Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_707785 V1024990 RV0883C S dNA-binding protein 0XSMI Cluster_392604 V1024991 P Sodium hydrogen exchanger COG4651 Cluster_406716 V1024992 L Transposase 11ZAW Cluster_761358 V1025000 S Hydrolase COG1011 Cluster_465199 V1249801 V restriction enzyme COG1002 Cluster_741565 V1249803 P Ferritin-like domain COG1528 Cluster_463126 V1249804 CKL_2970 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_465200 V1249809 map02010 V ABC transporter COG1131 Cluster_465201 V1249810 METE map00270,map00450,map01100,map01110,map01230 E Methionine synthase COG0620 Cluster_482747 V1249811 PPDK map00620,map00710,map01100,map01120 G pyruvate phosphate dikinase COG0574 Cluster_465202 V1249812 S Putative membrane peptidase family (DUF2324) 11XS0 Cluster_489705 V1249813 S NA 0XRBB Cluster_465203 V1249815 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_515258 V1249816 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_543130 V1249817 L CHC2 zinc finger domain protein COG0358 Cluster_465204 V1249819 NARG map00910,map01120,map02020 C nitrate reductase, alpha subunit COG5013 Cluster_465205 V1249821 O -hydrogenase maturation factor COG0309 Cluster_840189 V1249827 S Phage head-tail adaptor 122GS Cluster_734805 V1249828 L DNA packaging protein 123DA Cluster_905043 V1249831 NTPK map00190,map00680,map01100 C V-type sodium ATPase, K subunit COG0636 Cluster_567023 V1249832 NTPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_465207 V1249833 map00010,map00500,map00520,map02060 G PTS system beta-glucoside-specific transporter subunit IIABC COG2190 Cluster_603316 V1249836 M peptidase COG0739 Cluster_467289 V1249837 ASNB map00250,map00910,map01100,map01110,map01120 E asparagine synthetase COG0367 Cluster_502390 V1249838 RECG map03440 L ATP-dependent DNA helicase RecG COG1200 Cluster_523246 V1249839 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_465208 V1249840 XYLS map00052,map00500,map01100 M domain protein COG1501 Cluster_563829 V1249841 GLTD map00250,map00910,map01100,map01110,map01120,map01230 C, E pyridine nucleotide-disulfide oxidoreductase COG1894 Cluster_793135 V1249844 CSPA K Cold shock protein COG1278 Cluster_517925 V1249845 ARGS map00970 J arginyL-tRNA synthetase COG0018 Cluster_805248 V1249846 S NA 11NVG Cluster_724999 V1249847 YFEK S NA 17G0E@proNOG Cluster_715077 V1249848 S NA 16ZA7@proNOG Cluster_467290 V1249849 ENC_23920 S Phospholipid glycerol acyltransferase COG3176 Cluster_596233 V1249850 SRTC M (sortase) family COG3764 Cluster_592754 V1249852 S NA 0YBD7 Cluster_665646 V1249854 RPLY map03010 J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) COG1825 Cluster_649023 V1249856 GROS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) COG0234 Cluster_467292 V1249857 SCLAV_1660 K RNA Polymerase COG1595 Cluster_467293 V1249858 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_465209 V1249860 S Alpha beta hydrolase COG0596 Cluster_465210 V1249861 COMM O Mg chelatase subunit ChlI COG0606 Cluster_871976 V1249863 A28LD_1331 J Elongation factor Tu GTP binding domain COG0050 Cluster_762397 V1249864 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_467294 V1249865 ARCD S c4-dicarboxylate anaerobic carrier COG1288 Cluster_467295 V1249866 IUNH2 map00230,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_467296 V1249867 M domain protein COG4932 Cluster_469405 V1249869 M polysaccharide biosynthesis protein COG2244 Cluster_467297 V1249870 S Phage replisome organizer 0ZW0Q Cluster_699298 V1249871 L decarboxylase COG1611 Cluster_467298 V1249872 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_467299 V1249873 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_467300 V1249874 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_497199 V1249875 UVRD map03420,map03430 L ATP-dependent DNA helicase pcra COG0210 Cluster_467301 V1249876 map05100 S repeat protein 11TEE Cluster_467302 V1249877 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_614280 V1249878 S Addiction module antitoxin, RelB DinJ family 0XUTM Cluster_579649 V1249879 S Int_alpha 0ZYU3 Cluster_469406 V1249880 SUHB map00521,map00562,map00920,map01100,map01110,map01120,map04070 G inositol monophosphatase COG0483 Cluster_502391 V1249881 S NA 0XWY0 Cluster_467303 V1249884 PABB map00790 E, H Para-aminobenzoate synthase, component I COG0147 Cluster_741566 V1249885 map00400,map01100,map01110,map01230 E phospho-2-dehydro-3-deoxyheptonate aldolase COG2876 Cluster_467304 V1249887 Y0750 S Conserved Protein COG1479 Cluster_502392 V1249888 YQFA S UPF0365 protein COG4864 Cluster_469407 V1249889 SELB map00450,map00970 J Selenocysteine-specific translation elongation factor COG3276 Cluster_540221 V1249890 NAGA map00052,map00520,map01110 G GlcNAc 6-P deacetylase COG1820 Cluster_755100 V1249891 ALKA map03410 L 8-oxoguanine DNA glycosylase COG0122 Cluster_741567 V1249892 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_748211 V1249893 RPSE map03010 J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) COG0098 Cluster_744857 V1249894 PURK map00230,map01100,map01110 F phosphoribosylaminoimidazole carboxylase atpase subunit COG0026 Cluster_596234 V1249895 PPIA O PPIases accelerate the folding of proteins (By similarity) COG0652 Cluster_469408 V1249896 SACA map00052,map00500,map01100 G sucrose-6-phosphate hydrolase COG1621 Cluster_469409 V1249898 CLCAR_1091 T Histidine kinase COG0642 Cluster_467305 V1249900 ECFA1 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_469410 V1249902 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_469411 V1249903 S Cell wall-active antibiotics response protein (DUF2154) COG4758 Cluster_469412 V1249906 HSRA P multidrug resistance protein mdtD 16Q5H@proNOG Cluster_469413 V1249908 LMRA V ABC transporter, ATP-binding protein COG1132 Cluster_621692 V1249909 MSC_0232 L transposase protein A 11X8W Cluster_699299 V1249910 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_540222 V1249912 UGD map00040,map00053,map00500,map00520,map01100,map01110 M UDP-glucose 6-dehydrogenase COG1004 Cluster_599733 V1249915 S NA 11QUB Cluster_567024 V1249917 PEPC E peptidase 0XRNU Cluster_469415 V1249919 XDHA map00230,map01100,map01120 C Xanthine dehydrogenase COG1529 Cluster_554888 V1249921 I Lipid kinase, YegS Rv2252 BmrU family COG1597 Cluster_469416 V1249923 TOPB L Dna topoisomerase COG0550 Cluster_586087 V1249925 DEDA P SNARE associated Golgi COG0586 Cluster_641052 V1249927 VORB map00020,map00280,map00720,map01100,map01120 C 2-oxoglutarate oxidoreductase, alpha subunit COG0674 Cluster_540223 V1249929 S YitT family COG1284 Cluster_781247 V1249930 GCVT map00260,map00670,map00910,map01100 E The glycine cleavage system catalyzes the degradation of glycine (By similarity) COG0404 Cluster_589380 V1249931 S NA 0XQ5J Cluster_711696 V1249932 U TraG family COG3505 Cluster_633025 V1249933 S NA 0XSXQ Cluster_567025 V1249934 map00984 G, M 3-beta hydroxysteroid dehydrogenase isomerase COG0451 Cluster_471568 V1249936 MDH map00620,map00710,map01100,map01120,map02020 C malate dehydrogenase (Oxaloacetate-decarboxylating) COG0281 Cluster_471569 V1249941 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_507379 V1249942 SP_1331 K transcriptional regulator COG1737 Cluster_471570 V1249943 HTRE map05133 M outer membrane usher protein COG3188 Cluster_567026 V1249945 S ABC transporter, ATP-binding protein COG0488 Cluster_471572 V1249946 THII map00730,map01100,map04122 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) COG0301 Cluster_728286 V1249947 PCT map00620,map00640,map00643,map01100,map01120 I CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) COG4670 Cluster_473660 V1249949 FBPA K Fibronectin-binding protein COG1293 Cluster_738148 V1249950 RECG map03440 L ATP-dependent DNA helicase recG COG1200 Cluster_683316 V1249951 LACR K DeoRC COG1349 Cluster_665648 V1249952 PEPD E Dipeptidase COG4690 Cluster_744858 V1249953 S NA 0ZHU9 Cluster_618040 V1249955 MAF D Maf-like protein COG0424 Cluster_471575 V1249957 COBD map00860,map01100 H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) COG1270 Cluster_471576 V1249958 M Nucleoside-specific channel-forming protein, Tsx COG3248 Cluster_534539 V1249959 ASNC K regulatory protein, asnc COG1522 Cluster_471577 V1249960 K Peptidase S24-like COG2932 Cluster_471578 V1249962 CAT map00281,map00620,map00626,map01110,map01120 C Transferase COG0427 Cluster_696011 V1249963 S NA 0ZHU9 Cluster_471579 V1249965 SP_0341 S UPF0371 protein COG4868 Cluster_805249 V1249967 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_473662 V1249968 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_473664 V1249970 U, W Pfam:Hep_Hag COG5295 Cluster_770075 V1249972 YKII S NA 11GTZ Cluster_471580 V1249976 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_471581 V1249977 NHAP P Potassium proton antiporter COG3263 Cluster_610601 V1249981 TEH_00840 L Maturase COG3344 Cluster_473667 V1249985 GLNN map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG3968 Cluster_549112 V1249986 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_473668 V1249987 SP_1654 map00500,map00511,map01100 N Alpha-L-fucosidase 0XPGV Cluster_473669 V1249988 map02010 P ABC transporter, permease COG1175 Cluster_473670 V1249989 L metallophosphoesterase COG0420 Cluster_586088 V1249990 map00770,map01100,map01110 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) COG1893 Cluster_473672 V1249993 CPHY_1803 L transposase 0XQMH Cluster_699301 V1249995 S NA 1262Z Cluster_475828 V1249996 P tonB-dependent Receptor 0XQJQ Cluster_554889 V1249997 ASP S alkaline shock protein COG1302 Cluster_475829 V1249998 map00051 M Glycosyl transferase, family 2 COG1215 Cluster_637069 V1249999 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_582893 V1250001 FABK map00061,map01100 I 2-Nitropropane dioxygenase COG2070 Cluster_475830 V1250002 YHCG V abc transporter atp-binding protein COG1131 Cluster_475831 V1250003 TRKA P potassium transporter peripheral membrane COG0569 Cluster_475832 V1250004 CPDB map00230,map00240,map00760,map01100,map01110 F 5-nucleotidase COG0737 Cluster_621694 V1250005 S NA 0YW62 Cluster_473673 V1250006 RECQ map03018 L ATP-dependent DNA helicase RecQ COG0514 Cluster_515259 V1250009 SPOU J rrna methyltransferase COG0566 Cluster_473674 V1250011 S Phage tail tape measure protein, TP901 family COG5283 Cluster_473675 V1250012 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_531742 V1250013 K Transcriptional Regulator AraC Family 0ZYR5 Cluster_475834 V1250014 E 2-hydroxyglutaryl-CoA dehydratase COG1775 Cluster_473676 V1250015 YAAO map00310,map00330,map00960,map01100,map01110 E decarboxylase COG1982 Cluster_512556 V1250016 S B3 4 domain protein COG3382 Cluster_475836 V1250018 MAEB map00620,map00710,map01100,map01120,map02020 C Malic enzyme COG0281 Cluster_475837 V1250021 TNPX L Resolvase COG1961 Cluster_475839 V1250023 E Family 5 COG0747 Cluster_475840 V1250025 S radical SAM domain protein COG0535 Cluster_475841 V1250026 E Family 5 COG0747 Cluster_509989 V1250027 S NA 0Z20Q Cluster_478025 V1250029 PPK map00190,map03018 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) COG0855 Cluster_475842 V1250030 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_669935 V1250032 NHAC map00680 C Na H antiporter COG1757 Cluster_475843 V1250033 PHBA map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map02020 I acetyl-CoA COG0183 Cluster_475844 V1250036 S Metal dependent hydrolase COG2220 Cluster_687749 V1250037 L DNA binding domain protein 11TH0 Cluster_692237 V1250038 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_546070 V1250039 GLYA map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01230 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) COG0112 Cluster_546071 V1250040 YHFZ S NA 0YBQW Cluster_840191 V1250041 GLMU map00520,map01100,map01110 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) COG1207 Cluster_475845 V1250042 S conserved domain protein 11Q3F Cluster_475846 V1250043 C radical SAM domain protein COG1032 Cluster_653090 V1250045 PURC map00230,map01100,map01110 F Phosphoribosylaminoimidazolesuccinocarboxamide synthase COG0152 Cluster_557794 V1250046 YYBT T domain protein COG3887 Cluster_734806 V1250049 S NA 10NBR Cluster_649025 V1250050 YCAM E amino acid COG0531 Cluster_478026 V1250051 P Heavy-metal-associated domain COG2217 Cluster_741568 V1250052 MDH map00020,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120 C Malate dehydrogenase COG0039 Cluster_892294 V1250053 O ADP-ribosylglycohydrolase COG1397 Cluster_820867 V1250054 UPP map00240,map01100 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) COG0035 Cluster_475847 V1250055 YEJO U ATP-binding component of a transport system 16SGG@proNOG Cluster_478027 V1250057 M Outer membrane protein, OMP85 family 0XNPU Cluster_494687 V1250058 GATB map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 Cluster_478028 V1250059 V (ABC) transporter 0XQRE Cluster_512557 V1250060 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_531743 V1250061 SASA S Mediates binding to human platelets, possibly through a receptor-ligand interaction. Probably associated with virulence in endovascular infection (By similarity) 12CMI Cluster_478029 V1250062 S Na H antiporter COG2056 Cluster_526156 V1250063 S RteC protein 11NQH Cluster_487364 V1250065 MUTX L mutator MutT protein COG0494 Cluster_480425 V1250066 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (Alpha subunit) COG0587 Cluster_480426 V1250067 LDTA S ErfK YbiS YcfS YnhG COG1376 Cluster_725002 V1250069 CMK map00240,map00410,map00770,map01100,map01110 F Cytidine monophosphate kinase COG0283 Cluster_478031 V1250070 DEXB map00052,map00500,map01100 G Aamy COG0366 Cluster_557795 V1250071 L CHC2 zinc finger domain protein COG0358 Cluster_480427 V1250072 L N-6 DNA Methylase COG1002 Cluster_478032 V1250073 PYC map00020,map00620,map00720,map01100,map01120,map01230 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) COG1038 Cluster_570099 V1250075 M Sulfatase COG1368 Cluster_523247 V1250078 P Citrate transporter COG1055 Cluster_478033 V1250079 FLU M, U antigen 43 COG3468 Cluster_755101 V1250081 SCE2282 L IS66 Orf2 family protein COG3436 Cluster_665649 V1250082 S integral membrane protein 11Q41 Cluster_480428 V1250085 map02010 P ABC transporter COG1840 Cluster_478034 V1250086 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_633027 V1250088 S 3-5 exonuclease 11J3A Cluster_599734 V1250090 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_705465 V1250091 SFMH S Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) 177BF@proNOG Cluster_480430 V1250093 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_478035 V1250094 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_758619 V1250095 S Inherit from COG: ATPase (AAA COG1373 Cluster_589381 V1250097 V Type III restriction enzyme, res subunit 0ZVEA Cluster_480431 V1250099 LEUC map00290,map00660,map01100,map01110,map01210,map01230 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) COG0065 Cluster_480432 V1250100 BMUL_5533 S NA 0XPT9 Cluster_661429 V1250101 S MMPL family COG1033 Cluster_480433 V1250102 S amidinotransferase COG4874 Cluster_509990 V1250107 HSDS V specificity COG0732 Cluster_480434 V1250108 BCRA map02010 V ABC transporter COG1131 Cluster_480435 V1250109 LYTR K TRANSCRIPTIONal COG1316 Cluster_489706 V1250111 S NA 0YVPX Cluster_480436 V1250112 map00561,map00680,map01100,map01120,map04622 G Dihydroxyacetone kinase COG2376 Cluster_489707 V1250113 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (alpha subunit) COG0587 Cluster_777481 V1250115 ASD map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) COG0136 Cluster_777482 V1250117 RPSM map03010 J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits COG0099 Cluster_832392 V1250118 BMUL_5595 S PRTRC system ThiF family protein 11SE1 Cluster_665650 V1250119 BMUL_5593 S PRTRC system protein B 10F72 Cluster_596235 V1250122 GLPG S Rhomboid family COG0705 Cluster_543132 V1250124 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_480437 V1250125 S NA 0YH2T Cluster_480438 V1250126 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_480439 V1250129 PTCC map02060 G pts system COG1455 Cluster_762398 V1250130 S Glycosyl transferase family 11 11PMZ Cluster_482748 V1250131 VIAA S VWA domain protein interacting with AAA ATPase COG2425 Cluster_567027 V1250133 SMPB O Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) COG0691 Cluster_487365 V1250134 YHBJ S Displays ATPase and GTPase activities (By similarity) COG1660 Cluster_629177 V1250137 ATPA map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) COG1155 Cluster_482749 V1250138 SP_0482 S UPF0397 protein COG4720 Cluster_482750 V1250139 THRS map00020,map00300,map00630,map00720,map01100,map01110,map01120,map01210,map01230 C Aconitate hydratase COG1048 Cluster_832394 V1250141 S Conserved Protein 11U7C Cluster_482751 V1250144 NADE map00760,map01100 H nh(3)-dependent nad( ) synthetase COG0171 Cluster_549113 V1250145 VANZ V VanZ-like protein COG4767 Cluster_482752 V1250146 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_480441 V1250147 map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_537422 V1250148 S NA 11JFU Cluster_614282 V1250150 L Inherit from COG: DNA Methylase COG0827 Cluster_925588 V1250151 L Inherit from COG: DNA Methylase COG0827 Cluster_573306 V1250154 RSEP map04112 M Membrane-associated zinc metalloprotease COG0750 Cluster_482753 V1250156 LEUB map00290,map01100,map01110,map01210,map01230 E Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) COG0473 Cluster_692238 V1250157 YIHY S ribonuclease bn COG1295 Cluster_482754 V1250158 YOJN S ATPase associated with various cellular activities aaa_5 COG0714 Cluster_482755 V1250159 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_482756 V1250161 S NA 11ZQ3 Cluster_485071 V1250162 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_725003 V1250163 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_485072 V1250165 YJEE S protein family UPF0079, ATPase COG0802 Cluster_741569 V1250168 map00340,map00350,map00624,map01120 V methylase COG0827 Cluster_482757 V1250170 SOJ D Chromosome Partitioning Protein COG1192 Cluster_509991 V1250171 ALLB map00230,map00240,map01100,map01120 F Allantoinase (EC 3.5.2.5) COG0044 Cluster_708552 V1250172 S Protein of unknown function (DUF497) COG2929 Cluster_744859 V1250173 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_482758 V1250174 AGAS M isomerase COG2222 Cluster_531744 V1250175 RPLO map03010 J Binds to the 23S rRNA (By similarity) COG0200 Cluster_485074 V1250176 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_485075 V1250179 S CobW/HypB/UreG, nucleotide-binding domain COG0523 Cluster_551993 V1250183 S Bacteriophage peptidoglycan hydrolase 124AI Cluster_725004 V1250184 YPDE map00500,map01100 E Peptidase m42 family protein COG1363 Cluster_567028 V1250185 GLGB map00500,map01100,map01110 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) COG0296 Cluster_485077 V1250186 M Inherit from COG: Glycosyl Hydrolase Family 88 0XPDP Cluster_485078 V1250188 CADA P p-type atpase COG2217 Cluster_485079 V1250189 GLGB map00500,map01100,map01110 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) COG0296 Cluster_751630 V1250191 OCAR_7578 map00051,map00053,map00520,map01100,map01120,map02060 G pts system COG2893 Cluster_773755 V1250192 map00051,map00520,map01100,map02060 G PTS System COG3716 Cluster_485080 V1250193 M polysaccharide biosynthesis protein 0XNV1 Cluster_570100 V1250194 KTRA P domain protein COG0569 Cluster_485081 V1250195 YHCG V abc transporter atp-binding protein COG1131 Cluster_485082 V1250196 S Secreted protein 0XRGW Cluster_781248 V1250202 S Phage XkdN-like protein 0XWEU Cluster_520492 V1250205 S NA 0ZUR0 Cluster_649026 V1250207 MHQR K transcriptional regulator), MarR family 11UT8 Cluster_485084 V1250209 MGTE P magnesium transporter COG2239 Cluster_699302 V1250210 NADX map00760,map01100 H Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) COG1712 Cluster_485085 V1250212 S NA 101UU Cluster_487366 V1250213 AMAA map00360 E Peptidase dimerisation domain COG1473 Cluster_487367 V1250214 URAA F permease COG2233 Cluster_485086 V1250215 map00300,map01100,map01110,map01120,map01230 E, M Dihydrodipicolinate synthase COG0329 Cluster_557796 V1250216 P drug resistance transporter, EmrB QacA subfamily 0XNN3 Cluster_738149 V1250222 YRBD E amino acid carrier protein COG1115 Cluster_586089 V1250223 L terminase (Small subunit) COG3728 Cluster_813270 V1250224 S NA 11MG2 Cluster_487369 V1250226 GPPA map00230 F, P ppx gppa phosphatase COG0248 Cluster_485088 V1250228 ILYOP_1740 map00564,map00730 C fad dependent oxidoreductase COG0579 Cluster_625485 V1250229 PERMEASE S permease COG0701 Cluster_625486 V1250230 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_485089 V1250231 ASPB K Transcriptional regulator COG1167 Cluster_563830 V1250232 YQEV J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) COG0621 Cluster_644937 V1250234 COAX map00770,map01100 K Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) COG1521 Cluster_793136 V1250235 YTJA S Could be involved in insertion of integral membrane proteins into the membrane (By similarity) COG0759 Cluster_487370 V1250236 ATPC map00190,map00680,map01100 C ATP synthase, subunit 0XPA7 Cluster_485090 V1250237 YIEG S Xanthine uracil vitamin C permease COG2252 Cluster_485091 V1250238 M Inherit from COG: YD repeat protein COG3209 Cluster_509992 V1250240 K Transcriptional regulator, DeoR family COG1349 Cluster_487371 V1250241 SRTB U sortase, SrtB family COG4509 Cluster_669936 V1250242 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_487372 V1250243 S Inherit from COG: leucine Rich Repeat COG4886 Cluster_744860 V1250244 map00362,map01100,map01120 C Hydrolase COG0596 Cluster_487373 V1250246 map02010 P ABC superfamily ATP binding cassette transporter ABC protein COG1122 Cluster_549115 V1250247 RPSH map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) COG0096 Cluster_531745 V1250248 EUTJ E ethanolamine utilization protein eutJ COG4820 Cluster_487374 V1250249 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_751632 V1250250 RPSM map03010 J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits COG0099 Cluster_633029 V1250251 PTPA T Low molecular weight phosphotyrosine protein phosphatase COG0394 Cluster_487375 V1250253 TRAD U Conjugative transfer protein COG3505 Cluster_699303 V1250254 S Endonuclease Exonuclease phosphatase family protein 11IVG Cluster_487376 V1250255 M Cell wall binding repeat 2-containing protein COG2247 Cluster_678770 V1250257 S Protein of unknown function (DUF2874) 0YKIR Cluster_582894 V1250258 P Voltage gated chloride channel COG0038 Cluster_487377 V1250262 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_531746 V1250263 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_582895 V1250265 POTD map02010 E ABC transporter COG0687 Cluster_603319 V1250266 LDH map00010,map00051,map00270,map00363,map00591,map00620,map00625,map00640,map00650,map01100,map01110,map01120 C Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) COG0039 Cluster_540224 V1250270 S NA 0Y8QF Cluster_487378 V1250271 S 5-bromo-4-chloroindolyl phosphate hydrolysis protein 111JX Cluster_534540 V1250272 ARCA map00330,map01100,map01110 E Arginine dihydrolase COG2235 Cluster_871977 V1250275 RPLU map03010 J This protein binds to 23S rRNA in the presence of protein L20 (By similarity) COG0261 Cluster_487379 V1250277 S domain-containing protein 11PBU Cluster_487380 V1250278 ARGF map00330,map01100,map01110,map01230 E ornithine carbamoyltransferase COG0078 Cluster_487381 V1250279 THIF map00730,map01100,map04122 H Thiamine biosynthesis protein ThiF COG0476 Cluster_618041 V1250280 S NA 11H1H Cluster_489708 V1250283 L NA 11GDS Cluster_487382 V1250285 V Mate efflux family protein COG0534 Cluster_489709 V1250287 map00540 S Ghmp kinase COG2605 Cluster_489710 V1250288 M Glycoside hydrolase family 28 COG5434 Cluster_487383 V1250289 S NA 0Y835 Cluster_489711 V1250290 V ABC transporter COG1132 Cluster_487384 V1250291 PORU S NA 0XPE4 Cluster_487385 V1250292 S Abortive infection protein 11JRG Cluster_579650 V1250293 S Protein of unknown function (DUF2634) 11VAZ Cluster_618042 V1250295 THYA map00240,map00670,map01100 F Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) COG0207 Cluster_543133 V1250296 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_487386 V1250298 E, G Membrane COG0697 Cluster_725005 V1250299 ATOB map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map02020 I Acetyl-CoA acetyltransferase COG0183 Cluster_489712 V1250300 S NA 12D1P Cluster_489713 V1250301 APPA E Extracellular solute-binding protein, family 5 COG0747 Cluster_489714 V1250302 CPAP_0279 L Integrase core domain protein COG2801 Cluster_489715 V1250303 S Chromosome segregation ATPase 0XP5N Cluster_489716 V1250304 S s-layer domain-containing protein 11ZJU Cluster_489717 V1250305 map00190,map00680,map01100 C ATP synthase alpha/beta chain, C terminal domain COG1155 Cluster_489718 V1250306 DNAD L DNA replication protein DnaD COG3935 Cluster_489719 V1250308 YHEH V ABC transporter COG1132 Cluster_520493 V1250309 PGSA map00564,map01100 I cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase COG0558 Cluster_489720 V1250310 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_489721 V1250311 YDJG S Zinc finger domain 0XNNM Cluster_625488 V1250313 PURK map00230,map01100,map01110 F phosphoribosylaminoimidazole carboxylase atpase subunit COG0026 Cluster_502393 V1250317 BATD S BatD protein 0XR99 Cluster_573308 V1250318 M Transglycosylase COG5009 Cluster_637071 V1250319 NAGK G BadF BadG BcrA BcrD COG2971 Cluster_492197 V1250320 APEB E M18 family aminopeptidase COG1362 Cluster_738150 V1250322 THID map00730,map01100 H phosphomethylpyrimidine kinase COG0351 Cluster_773756 V1250323 THIC map00730,map01100 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) COG0422 Cluster_517927 V1250324 M Ompa motb domain protein COG2885 Cluster_711697 V1250326 L Integrase COG0582 Cluster_489723 V1250327 MEGL map00260,map00270,map00450,map00920,map01100,map01110,map01230 E methionine gamma-lyase COG0626 Cluster_489724 V1250328 ARGS map00970 J Arginyl-tRNA synthetase COG0018 Cluster_734807 V1250329 E, G permease COG0697 Cluster_492198 V1250330 U, W Inherit from COG: domain protein 121KM Cluster_489725 V1250331 PATB map00270,map00450,map00920,map01100,map01110,map01230 E Aminotransferase class I and II COG1168 Cluster_492199 V1250332 RECG map03420,map03440 L transcription-repair coupling factor COG1197 Cluster_492200 V1250333 map02010 V ABC superfamily ATP binding cassette transporter, ABC membrane protein COG1132 Cluster_492201 V1250334 RHAA map00040,map00051 G l-rhamnose isomerase COG4806 Cluster_489726 V1250335 AMET_0426 S Protein of unknown function (DUF3383) 11UPU Cluster_560847 V1250336 S repeat-containing protein COG0457 Cluster_809278 V1250338 MOAB map00790,map01100,map04122 H Molybdenum cofactor synthesis domain protein COG0521 Cluster_777483 V1250341 MUTT L hydrolase COG0494 Cluster_526158 V1250342 CSPB O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_913371 V1250343 SP_0239 S UPF0210 protein COG2848 Cluster_618043 V1250344 GCVR T UPF0237 protein COG3830 Cluster_489727 V1250345 PRMA J Methylates ribosomal protein L11 (By similarity) COG2264 Cluster_773757 V1250346 YABR J RNA binding s1 domain protein COG1098 Cluster_492202 V1250348 map00260,map00270,map00300,map01100,map01110,map01120,map01230 E Homoserine dehydrogenase COG0527 Cluster_492203 V1250349 MAEB map00620,map00710,map01100,map01120,map02020 C Malic enzyme COG0281 Cluster_526159 V1250352 NEUA map00520,map01100,map01110 M Cytidylyltransferase COG3980 Cluster_549116 V1250353 CSD1 L CRISPR-associated protein Csd1 family 0ZVNC Cluster_492205 V1250355 S Membrane COG1808 Cluster_492206 V1250356 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_492207 V1250357 TOPB L Dna topoisomerase COG0550 Cluster_504794 V1250358 EDA map00030,map00040,map00330,map00630,map01100,map01120 G 2-dehydro-3-deoxy-phosphogluconate aldolase COG0800 Cluster_629178 V1250359 GLGC map00500,map00520,map01100,map01110 G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) COG0448 Cluster_614283 V1250362 MURG map00550,map01100,map04112 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) COG0707 Cluster_494688 V1250364 RRGB M Lpxtg-motif cell wall anchor domain protein 0XSEP Cluster_494689 V1250365 RPH map00230,map00240,map01100 J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) COG0689 Cluster_494690 V1250366 S Inherit from COG: wd repeat COG2319 Cluster_606948 V1250369 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_492208 V1250370 BAMA map00061,map00780,map01100 M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane COG4775 Cluster_592755 V1250371 L helicase domain protein COG0553 Cluster_492209 V1250372 XYLS map00052,map00500,map01100 G hydrolase, family 31 COG1501 Cluster_725007 V1250373 S Protein of unknown function (DUF497) COG2929 Cluster_781249 V1250374 HDEF_2185 S NA COG3514 Cluster_582896 V1250376 RIBF map00740,map01100 H riboflavin biosynthesis protein ribF COG0196 Cluster_699304 V1250378 S NA 0Z01C Cluster_526160 V1250379 U, W Inherit from COG: domain protein COG5295 Cluster_494691 V1250380 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_494692 V1250382 M domain protein COG4932 Cluster_494693 V1250383 map02010 E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COG3842 Cluster_494694 V1250385 DPNA L helicase COG4646 Cluster_494695 V1250387 DNAQ map03022,map03420 L helicase COG1199 Cluster_494696 V1250389 CSHA map03018 L atp-dependent rna helicase COG0513 Cluster_674319 V1250390 S Proteins of 100 residues with WXG COG4842 Cluster_492210 V1250391 S NA 12026 Cluster_586090 V1250393 S caax amino terminal protease family protein COG1266 Cluster_494697 V1250396 L Transposase (IS4 family 0ZJC4 Cluster_494698 V1250397 TYPA T gtp-binding protein typa COG1217 Cluster_573310 V1250398 V FtsX-like permease family 0ZZC8 Cluster_494699 V1250399 S Radical SAM superfamily COG0641 Cluster_621695 V1250400 TRAQ S conjugative transposon protein TraQ 11SF8 Cluster_523249 V1250401 PYRF map00240,map01100 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) COG0284 Cluster_494700 V1250402 PPX1 map00230 F, P ppx gppa phosphatase COG0248 Cluster_576535 V1250404 CLVG S NA 11S28 Cluster_494701 V1250412 S Domain of unknown function (DUF2088) COG3875 Cluster_637072 V1250413 AMPG2 E, G, P Beta-lactamase induction signal transducer COG0477 Cluster_888179 V1250414 S Toxin-antitoxin system, toxin component, RelE family 122S4 Cluster_563831 V1250415 CYSK map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_549118 V1250418 C Binding Domain protein COG0348 Cluster_494702 V1250420 NTPB map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) COG1156 Cluster_494703 V1250421 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_543134 V1250423 YJHA S Endonuclease Exonuclease phosphatase 0XNVA Cluster_497200 V1250424 AMYE map02010 G solute-binding protein COG1653 Cluster_494704 V1250427 ASPB map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aminotransferase COG0436 Cluster_494705 V1250428 MDLA V ABC transporter, ATP-binding protein COG1132 Cluster_738151 V1250429 YCGA S c4-dicarboxylate anaerobic carrier COG1288 Cluster_721643 V1250430 RPST map03010 J Binds directly to 16S ribosomal RNA (By similarity) COG0268 Cluster_497201 V1250432 ILVY K transcriptional regulator COG0583 Cluster_494706 V1250433 E peptidase COG2195 Cluster_497203 V1250436 HPPA map00190 C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for COG3808 Cluster_546072 V1250438 CPOA M Glycosyl transferase COG0438 Cluster_725008 V1250440 map00052,map00500,map01100 G hydrolase COG1621 Cluster_497204 V1250441 ASA_0160 L IS630 family transposase COG3335 Cluster_497205 V1250443 YNII S Zinc finger domain 0XNNM Cluster_497206 V1250445 S s-layer domain-containing protein 0YAE9 Cluster_497207 V1250446 V ABC transporter, ATP-binding protein COG1132 Cluster_497209 V1250448 APPB E, P ABC transporter, permease protein COG0601 Cluster_497210 V1250453 S Membrane 0ZI5H Cluster_828639 V1250454 RPSU map03010 J 30S ribosomal protein S21 COG0828 Cluster_497211 V1250455 M OmpA family 0YA87 Cluster_497212 V1250456 MRCA map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_649027 V1250457 map00520,map01110 G hydrolase family, 3 COG1472 Cluster_563832 V1250458 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_497213 V1250459 FADD map00071,map01100,map03320,map04146,map04920 I Long-chain-fatty-acid--CoA ligase COG1022 Cluster_781252 V1250460 GRDB S Selenoprotein B, glycine betaine sarcosine D-proline reductase family 1C8HM@synNOG Cluster_497214 V1250461 map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aminotransferase COG0436 Cluster_728288 V1250462 NIKR K Transcriptional regulator (By similarity) COG0864 Cluster_497215 V1250463 S NA 11J0Q Cluster_809279 V1250464 BCD map00071,map00280,map00281,map00650,map01100,map01110 I acyl-CoA dehydrogenase COG1960 Cluster_728289 V1250465 ETFB map00910 C Electron transfer flavoprotein COG2086 Cluster_813271 V1250466 S Nitrogen regulatory protein P-II 11PAT Cluster_674320 V1250467 SPOVG M Could be involved in septation (By similarity) COG2088 Cluster_497216 V1250468 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_499859 V1250469 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_625489 V1250472 GLGB map00500,map01100,map01110 G 1,4-alpha-glucan branching enzyme COG0296 Cluster_905048 V1250473 map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_625490 V1250474 O glycyl-radical enzyme activating protein family COG1180 Cluster_801064 V1250475 XTH map03410 L Exodeoxyribonuclease III COG0708 Cluster_832396 V1250476 S acetyltransferase, (GNAT) family 11UXB Cluster_499861 V1250477 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_497217 V1250478 S ragb susd domaiN-containing protein 0Z7X3 Cluster_497218 V1250481 CCA map03013,map03018 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate COG0617 Cluster_499862 V1250482 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_702360 V1250483 RSFS S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) COG0799 Cluster_599735 V1250485 THIM map00730,map01100 H 4-methyl-5-beta-hydroxyethylthiazole kinase COG2145 Cluster_497219 V1250486 GOR map00480 C reductase COG1249 Cluster_526161 V1250488 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_678771 V1250489 YBIR P transporter COG0471 Cluster_871979 V1250490 S NA 0XSHC Cluster_603321 V1250492 RSMJ M Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) 170QW@proNOG Cluster_773758 V1250493 YJGR S ATP-binding protein COG0433 Cluster_499863 V1250494 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_499864 V1250495 XYNB I esterase COG0657 Cluster_781253 V1250496 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_499865 V1250497 L Domain protein COG0507 Cluster_499867 V1250500 K, T Peptidase M56 COG4219 Cluster_540225 V1250501 S sigma-70, region 4 0ZZ25 Cluster_509993 V1250503 L Primosomal protein, DnaI COG1484 Cluster_644939 V1250504 PHOP T regulator COG0745 Cluster_499868 V1250506 S nucleoside recognition domain protein COG3314 Cluster_560848 V1250507 S Membrane Fusion Protein 0ZZS9 Cluster_499869 V1250508 ARCA map00330,map01100,map01110 E Arginine dihydrolase COG2235 Cluster_499870 V1250509 NTPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_715079 V1250513 T Histidine kinase COG0642 Cluster_917704 V1250515 YRXA K 3H domain protein COG1827 Cluster_696013 V1250517 ARAN G extracellular solute-binding protein family 1 COG1653 Cluster_499872 V1250518 FTSK D cell division protein FtsK COG1674 Cluster_502394 V1250521 ATPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_592756 V1250523 S Membrane 0XQTX Cluster_499873 V1250524 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_502395 V1250527 map02010 P ABC transporter 0XQHT Cluster_499874 V1250530 L Pfam:Transposase_12 0ZKF2 Cluster_546073 V1250531 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_596236 V1250532 GLXK map00260,map00561,map00630,map01100,map01110 G Glycerate kinase COG1929 Cluster_499875 V1250533 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_502396 V1250538 OPPB E, P Oligopeptide ABC transporter, permease protein AppB COG0601 Cluster_499877 V1250539 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_499878 V1250541 V Mate efflux family protein COG0534 Cluster_728290 V1250542 S domain protein COG1418 Cluster_499879 V1250543 V Efflux ABC transporter, permease protein COG0577 Cluster_528923 V1250544 RIBF map00740,map01100 H riboflavin biosynthesis protein ribF COG0196 Cluster_589382 V1250545 S NA 11FYK Cluster_696014 V1250547 MGTE P magnesium transporter COG2239 Cluster_820868 V1250549 S NA 11R9W Cluster_596237 V1250550 MAQU_0025 L IstB domain-containing protein ATP-binding protein COG1484 Cluster_502397 V1250551 BPR_I0156 L transposase COG1943 Cluster_502398 V1250552 M YD repeat protein COG3209 Cluster_499881 V1250553 DPPF E ABC transporter COG4608 Cluster_618045 V1250555 map01040 E lipolytic protein G-D-S-L family COG2755 Cluster_502399 V1250558 UUP S Abc transporter COG0488 Cluster_871980 V1250559 RBSA S ABC transporter COG3845 Cluster_502400 V1250560 map00630,map01100,map01110 S Hydrolase COG0546 Cluster_844203 V1250564 S NA 0ZYSR Cluster_687754 V1250565 RIMM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) COG0806 Cluster_560849 V1250566 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_744861 V1250567 RARA L recombination factor protein RarA COG2256 Cluster_567029 V1250569 L Replication initiator protein A 0Y2JJ Cluster_502402 V1250571 CNA M domain protein 0ZWTG Cluster_502403 V1250572 S atp gtp-binding protein 11QV4 Cluster_621696 V1250573 PEPO O Endothelin-converting enzyme 1 COG3590 Cluster_502404 V1250574 NHAP P Potassium proton antiporter COG3263 Cluster_502405 V1250576 M Sulfatase COG1368 Cluster_621697 V1250577 ARSC P Transcriptional regulator, Spx MgsR family COG1393 Cluster_758621 V1250578 NNRE G Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity) COG0062 Cluster_502406 V1250579 S S-layer domain protein 12C8X Cluster_892299 V1250583 BIRA map00780,map01100 H Biotin- acetyl-CoA-carboxylase ligase COG1654 Cluster_637074 V1250584 S NA 11UQ8 Cluster_504795 V1250585 map02020 T ATPase histidine kinase DNA gyrase B HSP90 domain protein 0XNMH Cluster_504796 V1250586 NASD map00910,map01120 C nitrite reductase, (NAD(P)H) COG1251 Cluster_504797 V1250588 S NA 0ZHVH Cluster_502407 V1250589 MDLB map02010 V ABC transporter COG1132 Cluster_504798 V1250592 S NA 0YDFB Cluster_888181 V1250593 ACUB S (CBS) domain COG0517 Cluster_641054 V1250594 F Hydroxymethylpyrimidine transporter CytX COG1457 Cluster_502408 V1250595 NARJ map00910,map01120,map02020 C Nitrate reductase COG2180 Cluster_502409 V1250596 POLA_2 L DNA polymerase 0XRUF Cluster_610603 V1250597 YADE G polysaccharide deacetylase COG0726 Cluster_502410 V1250598 T Histidine kinase COG0642 Cluster_504799 V1250599 K parb-like COG1475 Cluster_576536 V1250601 PAND map00410,map00770,map01100,map01110 H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) COG0853 Cluster_502411 V1250602 BT_0485 L transposase is116 is110 is902 family COG3547 Cluster_509994 V1250603 DNAD L DNA replication protein DnaD COG3935 Cluster_504800 V1250604 YJBF S SNARE-like domain protein COG0398 Cluster_502413 V1250606 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_502414 V1250607 M Glycosyl transferase, family 2 11VE3 Cluster_554892 V1250608 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG3848 Cluster_504801 V1250609 YLME F alanine racemase domain protein COG0325 Cluster_817028 V1250610 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_502415 V1250611 NRFA map00910,map01120,map05132 P Plays a role in nitrite reduction (By similarity) COG3303 Cluster_504802 V1250612 PABC map00280,map00290,map00310,map00330,map00360,map00472,map00473,map00770,map00790,map01100,map01110,map01210,map01230 E brancheD-chain amino acid aminotransferase COG0115 Cluster_540226 V1250615 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_504803 V1250616 GLTA map00020,map00630,map00640,map01100,map01110,map01120,map01210,map01230 C citrate synthase COG0372 Cluster_502416 V1250617 S NA 0XRNH Cluster_502417 V1250620 S NA 101UU Cluster_504804 V1250622 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_504807 V1250627 NUC L nuclease COG1525 Cluster_728291 V1250628 M Catalyzes the conversion of a range of fructosamine 6- phosphates to glucose 6-phosphate and a free amino acid (By similarity) COG2222 Cluster_824839 V1250629 RPSL map03010 J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) COG0048 Cluster_504808 V1250630 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_657226 V1250631 YAJC map03060,map03070 U preprotein translocase, subunit YajC COG1862 Cluster_718339 V1250635 S Conserved domain protein COG4443 Cluster_504809 V1250637 YQEV J MiaB-like tRNA modifying enzyme COG0621 Cluster_614285 V1250640 CYSA2 map02010 E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COG3842 Cluster_504811 V1250641 ADH map00010,map00051,map00071,map00350,map00362,map00363,map00591,map00620,map00621,map00622,map00625,map00626,map00630,map00650,map01100,map01110,map01120 C alcohol dehydrogenase COG1454 Cluster_504812 V1250642 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_789363 V1250643 S Domain of unknown function DUF20 COG0628 Cluster_504813 V1250646 S AAA-ATPase 0XQ4X Cluster_504814 V1250647 MALQ map00500,map01100 G 4-alpha-glucanotransferase (EC 2.4.1.25) COG1640 Cluster_507382 V1250649 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_715080 V1250651 T TPR COG3920 Cluster_504815 V1250652 SACA map00052,map00500,map01100 G sucrose-6-phosphate hydrolase COG1621 Cluster_549119 V1250654 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_554893 V1250655 T Two component transcriptional regulator (Winged helix family COG0745 Cluster_504817 V1250656 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_766356 V1250657 S NA 0Y0MT Cluster_844205 V1250658 S NA 124UU Cluster_683317 V1250659 S integral membrane protein 11Q41 Cluster_507383 V1250660 HIPO map00360 E amidohydrolase COG1473 Cluster_504818 V1250661 S NA 101UU Cluster_507386 V1250664 SCLAV_1921 map02010 V abc transporter COG1132 Cluster_504820 V1250666 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_504821 V1250667 DING map00230,map00240,map01100,map03030,map03430,map03440 L helicase COG2176 Cluster_526162 V1250668 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_507387 V1250669 P Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) COG4206 Cluster_797121 V1250671 FUCA map00051 G Class II aldolase adducin family protein COG0235 Cluster_797122 V1250672 DHAK map00561,map00680,map01100,map01120,map04622 G Dihydroxyacetone kinase COG2376 Cluster_507388 V1250673 L Resolvase COG1961 Cluster_504822 V1250676 T response regulator COG3279 Cluster_507390 V1250677 S NA 11QVU Cluster_504823 V1250679 VMRA V Mate efflux family protein COG0534 Cluster_507391 V1250680 G Broad-specificity glycosaminoglycan lyase (By similarity) 0Y18H Cluster_504824 V1250682 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_793138 V1250683 S Hydrid cluster protein-associated redox disulfide domain protein 123UM Cluster_507392 V1250684 LDH map00010,map00051,map00270,map00363,map00591,map00620,map00625,map00640,map00650,map01100,map01110,map01120 C L-lactate dehydrogenase COG0039 Cluster_507393 V1250687 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_507394 V1250688 K transcriptional regulator MERR family COG0789 Cluster_507395 V1250689 SHP S Cell surface heme-binding protein Shp 12069 Cluster_507396 V1250690 M domain protein COG4932 Cluster_507397 V1250692 PROTEASE map05120 O Peptidase U32 COG0826 Cluster_507398 V1250693 S tripeptidyl aminopeptidase 0XQ98 Cluster_507399 V1250694 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_657227 V1250696 TRXA O Thioredoxin COG0526 Cluster_507400 V1250698 GPMI map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0696 Cluster_507401 V1250699 map00627,map00740,map01120,map05152 S Acid phosphatase 11X3R Cluster_758622 V1250700 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_523250 V1250701 S NA 0ZK9J Cluster_509995 V1250703 ASD map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) COG0136 Cluster_633031 V1250704 S Glycosyl transferase family 11 11PMZ Cluster_734809 V1250706 K Transcriptional regulator COG1414 Cluster_687756 V1250707 RPSI map03010 J 30S ribosomal protein S9 COG0103 Cluster_582897 V1250708 HSLO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) COG1281 Cluster_507402 V1250710 M domain protein COG4932 Cluster_579651 V1250711 K, L domain protein COG0553 Cluster_507403 V1250712 LIN1244 S DnaD domain protein 11TF8 Cluster_507404 V1250713 YVDE J Glutamine amidotransferase COG2071 Cluster_534541 V1250714 S NA 102QB Cluster_554894 V1250715 YCCC map00250,map00330,map00460,map00471,map00910,map01100,map01110,map01120,map02020 E L-asparaginase COG0252 Cluster_509997 V1250720 S KAP P-loop COG4928 Cluster_509998 V1250721 PTH_0213 L Integrase COG0582 Cluster_687757 V1250722 C Alcohol dehydrogenase zinc-binding domain protein COG1063 Cluster_540227 V1250723 HEMA map00860,map01100,map01110 H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) COG0373 Cluster_603322 V1250724 IOLE map00562,map01100,map01120 G Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) COG1082 Cluster_592758 V1250726 ECPD N, U Chaperone COG3121 Cluster_509999 V1250728 FBA map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01230 G Fructose-1,6-bisphosphate aldolase, class II COG0191 Cluster_711702 V1250729 DEOB map00030,map00230 G Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) COG1015 Cluster_510000 V1250730 PGM map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_725010 V1250731 J s4 domain protein COG1188 Cluster_510001 V1250732 T Pasta domain containing protein COG2815 Cluster_510002 V1250734 S NA 0XS0Q Cluster_770077 V1250735 SECE map03060,map03070 U Preprotein translocase SecE subunit 0XUXP Cluster_510003 V1250736 RFBA map00521,map00523,map01100,map01110 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) COG1209 Cluster_510004 V1250737 GSPE map03070 U type ii secretion system protein e COG2804 Cluster_510006 V1250739 S radical SAM domain protein 125RF Cluster_510007 V1250740 M Sulfatase COG1368 Cluster_510008 V1250741 FRWC G PTS System COG1299 Cluster_603323 V1250743 MANY map00051,map00520,map01100,map02060 G PTS System COG3715 Cluster_517928 V1250744 S NA 0Z42P Cluster_510009 V1250745 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_510010 V1250746 YBTP map02010 V ABC transporter COG1132 Cluster_657228 V1250747 PEPD E Dipeptidase COG4690 Cluster_512559 V1250748 S hi0933 family COG2081 Cluster_512561 V1250750 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_510011 V1250751 S SusD family 0YBPW Cluster_728292 V1250753 HCP C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) COG1151 Cluster_725011 V1250756 S NA 0YR8M Cluster_570101 V1250757 LSPA map03060 M, U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) COG0597 Cluster_563834 V1250758 S NA 101UU Cluster_512562 V1250759 YJEE S protein family UPF0079, ATPase COG0802 Cluster_512563 V1250760 PRDA map00330 S d-proline reductase 0ZZWY Cluster_711703 V1250761 HYPB H uba thif-type nad fad binding protein COG1179 Cluster_844207 V1250762 LOLD map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_596238 V1250764 THID map00730,map01100 H phosphomethylpyrimidine kinase COG0351 Cluster_683318 V1250765 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_510012 V1250767 UUP S Abc transporter, ATP-binding protein COG0488 Cluster_641055 V1250768 RPLX map03010 J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) COG0198 Cluster_528924 V1250770 S domain protein 0Y8F3 Cluster_512564 V1250771 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_512565 V1250772 NUSA K Transcription elongation factor NusA COG0195 Cluster_510013 V1250773 G Alpha-1,2-mannosidase COG3537 Cluster_512566 V1250774 S NA 0Z7FX Cluster_683319 V1250775 L Resolvase COG1961 Cluster_512567 V1250776 YFNB map00361,map00625,map01100,map01120 S Hydrolase COG1011 Cluster_913373 V1250778 RBPA S NA 11U3N Cluster_512569 V1250779 S NA 0YCIZ Cluster_512571 V1250781 S Listeria-Bacteroides repeat domain (List_Bact_rpt) 0YG1D Cluster_789364 V1250782 S NA 0YHGG Cluster_531747 V1250784 OADA map00020,map00330,map00620,map00720,map01100,map01120,map01230 C Oxaloacetate decarboxylase COG5016 Cluster_512572 V1250785 F Permease family COG2233 Cluster_551994 V1250786 LYTR2 K TRANSCRIPTIONal COG1316 Cluster_512573 V1250787 KDGT P The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) 0XNUJ Cluster_809282 V1250789 map00330,map01100 S Carbon-nitrogen hydrolase 11WGJ Cluster_868013 V1250790 SUFC O feS assembly ATPase SufC COG0396 Cluster_515260 V1250791 PDXY map00750,map01100 H Pyridoxal kinase COG2240 Cluster_512574 V1250792 SKFE map02010 V Abc transporter COG1131 Cluster_871981 V1250793 YEIH S Membrane COG2855 Cluster_515261 V1250794 RNHA map00010,map00260,map00680,map00860,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_526163 V1250795 S minor capsid protein 0XSIM Cluster_512575 V1250796 PGCA map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_512576 V1250797 H uba thif-type nad fad binding protein COG1179 Cluster_515262 V1250798 AMY13I map00500,map01100,map04973 G Alpha-amylase COG0366 Cluster_610604 V1250799 APEB E M18 family aminopeptidase COG1362 Cluster_573311 V1250800 I protein, conserved in bacteria COG3581 Cluster_512577 V1250801 UGD map00040,map00053,map00500,map00520,map01100,map01110 M UDP-glucose 6-dehydrogenase COG1004 Cluster_512578 V1250802 M group 1 glycosyl transferase COG0438 Cluster_512579 V1250806 REPA D Partitioning Protein COG1192 Cluster_606949 V1250807 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_523251 V1250810 GRDC C reductase complex component C 0XQ4S Cluster_515263 V1250812 MURE map00300,map00550 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_517929 V1250814 OCAR_5706 map00010,map00051,map00071,map00350,map00363,map00591,map00625,map00626,map00650,map00830,map00980,map00982,map01100,map01110,map01120 C alcohol dehydrogenase COG0604 Cluster_512580 V1250816 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G phosphohexokinase COG0205 Cluster_512581 V1250817 PSTS2 map02010,map02020,map05152 P Phosphate-binding protein COG0226 Cluster_840195 V1250818 ASA_1780 L IS630 family transposase COG3335 Cluster_692240 V1250819 BGLG K antiterminator COG3711 Cluster_876070 V1250820 UPP map00240,map01100 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) COG0035 Cluster_696015 V1250821 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_614286 V1250822 FEPC map02010 P ABC, transporter COG1120 Cluster_512582 V1250823 COPA P p-type atpase COG2217 Cluster_669937 V1250826 APBE H ApbE family COG1477 Cluster_515266 V1250829 S inner membrane protein YbaN COG2832 Cluster_589383 V1250830 OPPF map02010 E, P ABC transporter, ATP-binding protein COG4608 Cluster_515267 V1250831 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_741571 V1250832 HBD map00360,map00362,map00650,map01100,map01120 I 3-hydroxyacyl-CoA dehydrogenase COG1250 Cluster_515268 V1250833 YAAA L UPF0246 protein COG3022 Cluster_515269 V1250835 S NA 0ZNJG Cluster_515270 V1250836 S hi0933 family COG2081 Cluster_515271 V1250837 S Zn-finger containing protein 121ND Cluster_515272 V1250838 L Terminase, large subunit COG4626 Cluster_734810 V1250839 M hydrolase, family 25 COG3757 Cluster_515273 V1250841 METY map00270,map00450,map00920,map01100,map01110,map01230 E O-acetylhomoserine COG2873 Cluster_789365 V1250845 RBSC map02010 G ABC, transporter COG1172 Cluster_528925 V1250846 S NA 0YK1E Cluster_515275 V1250847 L Resolvase COG1961 Cluster_517930 V1250849 UPPP map00550 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) COG1968 Cluster_896427 V1250850 S conjugative transposon protein 11JUF Cluster_515276 V1250851 DLTA H Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) COG1020 Cluster_537423 V1250853 BCSA map00500,map01100 M Cellulose synthase catalytic subunit COG1215 Cluster_515277 V1250855 UGPA map02010 P binding-protein-dependent transport systems inner membrane component COG1175 Cluster_517931 V1250856 S amidohydrolase COG2159 Cluster_644941 V1250857 SPOU J rrna methyltransferase COG0566 Cluster_734811 V1250858 NFSA map00051,map00190,map00363,map00591,map00625,map00633,map00650,map01100,map01120 C nitroreductase COG0778 Cluster_517932 V1250862 L D12 class N6 adenine-specific DNA methyltransferase 110K5 Cluster_515278 V1250863 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_515279 V1250864 map00051 M glycosyl transferase 11GWY Cluster_515280 V1250865 map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_515281 V1250867 M Cell wall binding repeat 2-containing protein COG2247 Cluster_515282 V1250868 S Membrane 0XQXB Cluster_517933 V1250871 L Integrase 11F4A Cluster_554895 V1250872 I protein, conserved in bacteria COG3581 Cluster_665651 V1250873 S NA 0Z7I3 Cluster_515283 V1250875 DPNA L helicase COG4646 Cluster_618047 V1250876 CRT map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00630,map00640,map00650,map00720,map00903,map00930,map01100,map01110,map01120 I 3-hydroxybutyryl-CoA dehydratase COG1024 Cluster_523252 V1250877 TRKA P TrkA-N domain protein COG0569 Cluster_789366 V1250878 RARA L recombination factor protein RarA COG2256 Cluster_758624 V1250879 MCSB map00330 E ATP guanido phosphotransferase COG3869 Cluster_517934 V1250881 SBCD L SbcCD D subunit COG0420 Cluster_517935 V1250885 O Zn-dependent protease COG5504 Cluster_517936 V1250886 V abc transporter permease protein COG0577 Cluster_515284 V1250888 PPID O Peptidyl-prolyl cis-trans isomerase COG0760 Cluster_515285 V1250890 SPEA map00330,map01100 E Catalyzes the biosynthesis of agmatine from arginine (By similarity) COG1166 Cluster_515286 V1250891 S tonB-dependent Receptor 0XNVP Cluster_828642 V1250892 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III alpha subunit COG0587 Cluster_557798 V1250893 SPOU2 map00340,map00350,map00624,map01120 J tRNA rRNA methyltransferase COG0566 Cluster_665652 V1250895 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_517937 V1250896 PORU S NA 0XPE4 Cluster_888183 V1250898 L Resolvase COG1961 Cluster_793139 V1250899 Y0392 S TIM-barrel signal transduction protein COG5564 Cluster_517939 V1250901 S Metal dependent hydrolase COG2220 Cluster_517940 V1250902 GSHB map00480,map01100 H glutathione synthase COG0189 Cluster_517941 V1250903 LPTD M involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) COG1452 Cluster_517942 V1250904 S copper amine 0XP8R Cluster_517943 V1250905 HOXA map02020 T Sigma-54 interaction domain protein COG2204 Cluster_517944 V1250906 V ABC transporter, permease protein 0XP9H Cluster_517946 V1250908 HTRB map00540,map01100 M Lipid A Biosynthesis COG1560 Cluster_517947 V1250909 HOM E saf domain-containing protein COG4091 Cluster_517948 V1250910 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_517949 V1250914 FEOB P Ferrous iron transport protein B COG0370 Cluster_517950 V1250915 GLNP E amino acid AbC transporter COG0765 Cluster_517951 V1250916 map00230 S phosphorylase 11F11 Cluster_517952 V1250917 PEPD E Dipeptidase COG4690 Cluster_517953 V1250918 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_517954 V1250919 NAPA P (Na H) antiporter COG0589 Cluster_543135 V1250920 YQFL S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) COG1806 Cluster_557799 V1250921 JAG S Single-stranded nucleic acid binding R3H domain-containing protein COG1847 Cluster_517955 V1250922 RECG map03440 L ATP-dependent DNA helicase RecG COG1200 Cluster_517956 V1250923 M Membrane 0XSF8 Cluster_517957 V1250924 OPPF map02010 E (ABC) transporter COG4608 Cluster_520496 V1250925 IDSA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_517958 V1250926 RSGA G May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) COG1162 Cluster_820869 V1250927 YHBJ S Displays ATPase and GTPase activities (By similarity) COG1660 Cluster_828643 V1250928 CG3417 map00230,map00240 L nudix hydrolase COG0494 Cluster_517959 V1250929 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_809283 V1250930 S NA 125ZN Cluster_721645 V1250934 S Nitroreductase 11NZA Cluster_517960 V1250937 YGEV K Transcriptional regulator COG3829 Cluster_520497 V1250938 S Membrane COG3174 Cluster_517961 V1250939 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_517962 V1250940 DGOK map00052,map01100 G 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 COG3734 Cluster_517963 V1250942 P Na Pi-cotransporter COG1283 Cluster_517964 V1250943 B, K histone acetyltransferase COG1243 Cluster_520498 V1250944 YIHR G Aldose-1-epimerase COG2017 Cluster_517965 V1250945 NYLA map00330,map00360,map00380,map00627,map00643,map01120 J amidase (EC COG0154 Cluster_517966 V1250946 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_520499 V1250947 MREC M Involved in formation and maintenance of cell shape (By similarity) COG1792 Cluster_531748 V1250949 V Inherit from COG: Type I site-specific deoxyribonuclease COG0610 Cluster_653091 V1250950 S Domain of unknown function (DUF955) 11SIZ Cluster_517967 V1250952 S NA 0ZZGV Cluster_603324 V1250955 L UPF0102 protein COG0792 Cluster_606950 V1250956 FABH map00061,map01100 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) COG0332 Cluster_570102 V1250957 C Flavodoxin COG0716 Cluster_520501 V1250958 S NA 17WAW@proNOG Cluster_563836 V1250962 RPOE K RNA Polymerase 0XT41 Cluster_520502 V1250963 map02020 K Transcriptional regulator, ARAC family 11AZ4 Cluster_520503 V1250964 PRTC map05120 O collagenase COG0826 Cluster_520504 V1250965 GLYA map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01230 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) COG0112 Cluster_836287 V1250967 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_520505 V1250968 VDLC S KR domain COG1028 Cluster_520506 V1250970 MT0613 S integral membrane protein COG0392 Cluster_540228 V1250971 E Family 5 COG0747 Cluster_520507 V1250973 PEPP E peptidase, M24 COG0006 Cluster_520508 V1250974 map00550,map01100 M glycosyl transferase, family 51 COG0744 Cluster_520509 V1250975 M glycosyltransferase group 2 family protein COG1215 Cluster_520510 V1250978 S SusD family 0XQ9D Cluster_520511 V1250979 T Response regulator receiver domain protein COG0745 Cluster_520514 V1250982 TRKA P potassium transporter peripheral membrane COG0569 Cluster_520515 V1250984 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_520516 V1250986 SUN J Fmu (Sun) domain-containing protein COG0144 Cluster_592759 V1250987 ADK map00230,map00240,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_520517 V1250988 URAA F permease COG2233 Cluster_520518 V1250989 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_520519 V1250990 S Rib/alpha-like repeat 10008 Cluster_637075 V1250991 BMUL_2468 S Integrase 17D6W@proNOG Cluster_523253 V1250992 S YitT family COG1284 Cluster_520520 V1250993 map02020 T regulatoR COG2197 Cluster_520521 V1250995 E Extracellular solute-binding protein, family 5 COG0747 Cluster_557800 V1250996 H IA, variant 3 COG0637 Cluster_523254 V1250997 HPRK T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) COG1493 Cluster_824842 V1250998 RPLJ map03010 J 50s ribosomal protein L10 COG0244 Cluster_523255 V1251001 PURL F phosphoribosylformylglycinamidine synthase COG0047 Cluster_576537 V1251004 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate (By similarity) COG0167 Cluster_705467 V1251005 T fha domain-containing protein COG1716 Cluster_741573 V1251008 SCPA S Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) COG1354 Cluster_520523 V1251010 G Domain-Containing protein 11Q0T Cluster_741574 V1251011 map02010 P Periplasmic binding protein COG0614 Cluster_721646 V1251014 S Excisionase 11V59 Cluster_570103 V1251015 map04141 O Heat shock protein 11Y7C Cluster_523256 V1251016 YBHF map02010 V ABC, transporter COG1131 Cluster_744862 V1251018 P Transporter COG0733 Cluster_828645 V1251019 P Transporter COG0733 Cluster_523258 V1251020 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_523259 V1251021 map00360,map00362,map00650,map01100,map01120 C Dehydrogenase COG1250 Cluster_523260 V1251022 YDIA S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) COG1806 Cluster_711704 V1251023 CARD K Transcriptional regulator (CarD family COG1329 Cluster_523261 V1251024 DAPF map00300,map01100,map01110,map01120,map01230 E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) COG0253 Cluster_523262 V1251025 HYDG map00730,map01100 H biosynthesis protein thiH COG1060 Cluster_523263 V1251026 BGAA map00040,map00052,map00500,map00511,map00531,map00600,map00860,map00944,map00983,map01100,map04142 G hydrolase family 2, sugar binding COG3250 Cluster_523264 V1251028 SUGC map02010 G (ABC) transporter COG3839 Cluster_523265 V1251029 XDHD map00230,map00450,map01100,map01120 C Xanthine dehydrogenase COG1529 Cluster_523266 V1251030 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_523267 V1251031 T ATPase histidine kinase DNA gyrase B HSP90 domain protein 0XNMH Cluster_669939 V1251032 SECD map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) COG0342 Cluster_523268 V1251034 M Pilin isopeptide linkage domain protein 11AV1 Cluster_523269 V1251035 map03440 L UvrD REP helicase COG1074 Cluster_637076 V1251037 S NA 11RAW Cluster_523270 V1251038 PHOR map02020 T Histidine kinase 0XNMH Cluster_523272 V1251040 JAG S Single-stranded nucleic acid binding R3H domain-containing protein COG1847 Cluster_523273 V1251041 T response regulator 11GEV Cluster_523274 V1251042 YFIH S Multi-copper polyphenol oxidoreductase laccase COG1496 Cluster_523275 V1251043 IRP P tonB-dependent Receptor COG1629 Cluster_546075 V1251045 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_929011 V1251046 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_696016 V1251047 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_526164 V1251049 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_705468 V1251050 V T5orf172 0XQ8K Cluster_523277 V1251051 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_526165 V1251053 YLBB V abc transporter permease protein COG0577 Cluster_683320 V1251054 ETFB map00910 C Electron transfer flavoprotein COG2086 Cluster_526166 V1251056 PLSC map00561,map00564,map01100 I Acyl-transferase COG0204 Cluster_526167 V1251057 ENC_23920 S Phospholipid glycerol acyltransferase COG3176 Cluster_573312 V1251058 PRSA O Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) COG0760 Cluster_523278 V1251059 RSGA G May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) COG1162 Cluster_526168 V1251060 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_573313 V1251061 PEPI map00330 E Releases the N-terminal proline from various substrates (By similarity) COG0596 Cluster_526169 V1251062 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_526170 V1251064 S NA 0ZTYV Cluster_665653 V1251067 DCTP C symporter COG1301 Cluster_528927 V1251069 NNRD G Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) COG0063 Cluster_526171 V1251071 S Membrane 0ZI5H Cluster_523279 V1251072 S NA 0ZTYV Cluster_526172 V1251076 GLTS E Sodium Glutamate Symporter COG0786 Cluster_523280 V1251077 ARGB map00330,map01100,map01110,map01210,map01230 E nag kinase COG0548 Cluster_526173 V1251080 KBL map00260,map00780,map01100 H 2-amino-3-ketobutyrate coenzyme A ligase COG0156 Cluster_855672 V1251082 K RNA polymerase sigma factor, sigma-70 family 0Y4P1 Cluster_526174 V1251085 S succinylglutamate desuccinylase aspartoacylase COG3608 Cluster_526175 V1251086 MSCS M mechanosensitive ion channel COG0668 Cluster_657229 V1251087 RNFE C Electron transport complex COG4660 Cluster_526176 V1251091 ABCB map02010 V ABC transporter COG1132 Cluster_526177 V1251092 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_528928 V1251093 FHUD map02010 P Periplasmic binding protein COG0614 Cluster_582899 V1251094 L DNA methylase n-4 n-6 domain protein COG0863 Cluster_526178 V1251095 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_526179 V1251096 V Type I restriction enzyme R protein N terminus (HSDR_N) COG0610 Cluster_871982 V1251098 NATA map02010,map02020 P ABC transporter COG4555 Cluster_721647 V1251101 THII map00730,map01100,map04122 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) COG0301 Cluster_801067 V1251104 K Transcriptional regulator COG1476 Cluster_526180 V1251105 YLBB V abc transporter permease protein COG0577 Cluster_528929 V1251107 S Phospholipase D endonuclease domain-containing protein 0Z3N0 Cluster_526181 V1251109 T His Kinase A (phospho-acceptor) domain COG2205 Cluster_528930 V1251110 SURB S G5 domain protein 0ZVV3 Cluster_537424 V1251111 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_526182 V1251115 TYPA T gtp-binding protein typa COG1217 Cluster_702361 V1251118 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_528931 V1251120 S NA 101UU Cluster_526183 V1251121 PHOR map02020 T Histidine kinase 0XNMH Cluster_526184 V1251122 YCBB S ErfK YbiS YcfS YnhG family protein COG2989 Cluster_661433 V1251124 PYRB map00240,map00250,map01100 F aspartate transcarbamylase COG0540 Cluster_526185 V1251125 LACC map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G tagatose-6-phosphate kinase COG1105 Cluster_528932 V1251128 M NA 0ZY8Y Cluster_528933 V1251129 GLXR map00280,map00630,map01100 I Dehydrogenase COG2084 Cluster_641056 V1251131 S NA 0Y3IW Cluster_599736 V1251133 S HTH_XRE 0ZZ7A Cluster_637077 V1251134 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_592760 V1251135 TYRB map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aromatic amino acid aminotransferase COG1448 Cluster_762401 V1251136 CAPM M Glycosyl transferase (Group 1 0XNZB Cluster_528934 V1251137 CYDC map02010 V ABC transporter, ATP-binding protein COG1132 Cluster_657230 V1251140 S Protein of unknown function (DUF975) COG5523 Cluster_678772 V1251141 LIVH map02010 E Branched-chain amino acid transport system permease COG0559 Cluster_528935 V1251142 ISPG map00900,map01100,map01110 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) COG0821 Cluster_715083 V1251144 PHOR map02020 T Histidine kinase 0XNMH Cluster_528936 V1251145 P TonB-dependent receptor Plug 0XNPQ Cluster_528937 V1251147 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_531749 V1251148 GK0308 L Transposase COG3464 Cluster_606951 V1251150 H IA, variant 3 COG0637 Cluster_543137 V1251151 C Biotin-requiring enzyme COG0508 Cluster_576538 V1251154 S Conjugative transposon TraK protein 11HQ1 Cluster_528939 V1251157 E DegT/DnrJ/EryC1/StrS aminotransferase family COG0520 Cluster_531750 V1251159 PCFF S Inherit from NOG: Bacterial mobilization protein (MobC) 11NEB Cluster_531751 V1251161 CAS1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) COG1518 Cluster_528940 V1251162 SCLAV_1770 S Radical SAM-linked protein COG5011 Cluster_599737 V1251163 HYMB map00190,map00910,map01100 C NADH dehydrogenase COG1894 Cluster_531752 V1251164 SRTB U sortase, SrtB family COG4509 Cluster_528941 V1251165 OPUCA map02010 E ABC transporter COG1125 Cluster_528942 V1251167 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_528943 V1251169 PRMA J Methylates ribosomal protein L11 (By similarity) COG2264 Cluster_797125 V1251170 VEG S Veg protein COG4466 Cluster_758625 V1251171 DEOD map00230,map00240,map00270,map00760,map01100,map01110 F purine nucleoside phosphorylase DeoD-type COG0813 Cluster_528944 V1251172 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_528945 V1251173 PORB map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120 C oxidoreductase, beta subunit COG1013 Cluster_528946 V1251174 V ABC transporter COG1132 Cluster_528947 V1251176 THRS map00020,map00300,map00630,map00720,map01100,map01110,map01120,map01210,map01230 C Aconitate hydratase COG1048 Cluster_696017 V1251178 BMUL_1547 K Transcriptional regulator 0XUB6 Cluster_528948 V1251181 S domain protein 0YF83 Cluster_606952 V1251182 map00051,map00363,map00591,map00625,map00650,map01100,map01120 C alcohol dehydrogenase COG1979 Cluster_528949 V1251184 ZWF map00030,map00480,map01100,map01110,map01120 G glucose-6-phosphate 1-dehydrogenase COG0364 Cluster_531754 V1251185 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_711706 V1251188 PSPE P domain protein COG0607 Cluster_528950 V1251189 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_531755 V1251191 L Virulence-associated protein e COG5545 Cluster_579653 V1251192 S Protein of unknown function (DUF3137) 11MSU Cluster_531756 V1251193 PFLD map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_531757 V1251194 SRLM K sorbitol operon transcription regulator COG3711 Cluster_531758 V1251195 S NA 101UU Cluster_592761 V1251196 ATPA map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_603325 V1251198 M cell wall binding 11T5H Cluster_586092 V1251199 LIVK map02010 E extracellular ligand-binding receptor COG0683 Cluster_549120 V1251202 S NA 0Z28V Cluster_531760 V1251203 S NA 11QPY Cluster_614287 V1251206 PARE L DNA topoisomerase IV (Subunit B) COG0187 Cluster_805254 V1251207 S lysozyme 0YC6U Cluster_531761 V1251208 PORB map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120 C oxidoreductase, beta subunit COG1013 Cluster_531762 V1251210 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_741577 V1251211 BDP_1102 V ABC transporter, ATP-binding protein COG1136 Cluster_531763 V1251212 HPPA map00190 C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for COG3808 Cluster_705469 V1251214 FNI map00900,map01100,map01110 C Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) COG1304 Cluster_531764 V1251215 AGCS E amino acid carrier protein COG1115 Cluster_531767 V1251219 K GntR family transcriptional regulator COG2188 Cluster_554896 V1251222 YABB map00340,map00350,map00624,map01120 L Methyltransferase COG4123 Cluster_531768 V1251223 PURF map00230,map00250,map01100,map01110 F glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_531769 V1251224 M glycosyl transferase family 11MME Cluster_531770 V1251225 S reductase COG1028 Cluster_531771 V1251227 DISA L Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) COG1623 Cluster_614288 V1251228 M Cell wall anchor domain protein 129AF Cluster_534543 V1251230 PEPF E Oligoendopeptidase f COG1164 Cluster_551995 V1251235 M domain protein COG4932 Cluster_534545 V1251236 SENA S Inherit from COG: Ankyrin Repeat COG0666 Cluster_606953 V1251237 ALL2459 S ATP GTP Binding Protein 0XQ3U Cluster_531772 V1251239 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_534546 V1251241 S copper amine 121X1 Cluster_618048 V1251242 GPPA map00230 F, P ppx gppa phosphatase COG0248 Cluster_534547 V1251244 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_563837 V1251245 ACTP P copper-exporting ATPase COG2217 Cluster_725014 V1251246 S NA 11M4I Cluster_531773 V1251247 YIEG S Xanthine uracil vitamin C permease COG2252 Cluster_708553 V1251248 O Peptidyl-prolyl cis-trans isomerase COG0545 Cluster_534548 V1251249 S NA 0XT1C Cluster_573314 V1251250 map00520,map01110 G domain protein COG3534 Cluster_534549 V1251251 M Transglycosylase COG0741 Cluster_531774 V1251253 ENC_19000 map00010 G beta-glucosidase COG2723 Cluster_534550 V1251254 S (LipO)protein 1AMN7@spiNOG Cluster_534552 V1251256 CCRM map04112 L DNA methylase N-4 N-6 COG0863 Cluster_560850 V1251257 CP_1013 map00520,map01100,map01110 G UTP-glucose-1-phosphate uridylyltransferase COG4284 Cluster_534553 V1251258 TGT J Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COG0343 Cluster_731586 V1251259 map02020,map02030 S methyl-accepting chemotaxis 0XQGH Cluster_687758 V1251261 map03070 S NA 122A7 Cluster_534554 V1251263 APPF map02010 E (ABC) transporter COG4608 Cluster_567031 V1251264 AAT O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) COG2360 Cluster_692241 V1251265 ADK map00230,map00240,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_540229 V1251266 U traE protein COG3451 Cluster_534555 V1251267 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_534556 V1251268 P TonB dependent receptor 0YABC Cluster_534557 V1251269 YJCE P Na H antiporter COG0025 Cluster_649029 V1251270 YBHK S UPF0052 protein COG0391 Cluster_534558 V1251271 THIW S thiw protein COG4732 Cluster_699307 V1251272 GRDE S reductase 0XPPI Cluster_582900 V1251275 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_537425 V1251276 S (LipO)protein 0XQK7 Cluster_534561 V1251282 YGEW E Carbamoyltransferase COG0078 Cluster_785348 V1251284 V Type ii restriction enzyme 11NKK Cluster_534562 V1251285 O Inherit from COG: glutaredoxin-related protein COG4545 Cluster_534563 V1251287 AHPF O Alkyl hydroperoxide reductase COG3634 Cluster_534564 V1251288 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_534566 V1251291 M (sortase) family COG3764 Cluster_766361 V1251293 S NA 11KFQ Cluster_777484 V1251294 S thioesterase Superfamily protein 11IYE Cluster_537427 V1251296 S NA 0XZUM Cluster_537428 V1251297 DPAL map00260,map00290,map01100,map01110,map01230 E Diaminopropionate ammonia-lyase COG1171 Cluster_537429 V1251298 L helicase COG4646 Cluster_665657 V1251301 SIGB K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG1191 Cluster_534567 V1251302 S alpha-2-macroglobulin COG2373 Cluster_534568 V1251303 CYDD map02010 V ABC, transporter COG4988 Cluster_537430 V1251304 FTSK D cell division protein FtsK COG1674 Cluster_579655 V1251305 YLBN S metal-binding protein COG1399 Cluster_641058 V1251306 FTN map00860 P ferritin COG1528 Cluster_537431 V1251307 V abc transporter permease protein 0XQE2 Cluster_589384 V1251309 NTH map03410 L endonuclease III COG0177 Cluster_534569 V1251311 U TraG family COG3505 Cluster_537432 V1251312 P Voltage gated chloride channel COG0038 Cluster_537433 V1251313 CYDC map02010 V Abc transporter COG1132 Cluster_614291 V1251314 P Ferric uptake regulator, Fur family COG0735 Cluster_537434 V1251315 V abc transporter permease protein 0XQE2 Cluster_705470 V1251317 S Domain of unknown function (DUF3127) 126YQ Cluster_644943 V1251318 S NA 124XV Cluster_537435 V1251319 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_537436 V1251320 PATB map00270,map00450,map00920,map01100,map01110,map01230 E Aminotransferase class I and II COG1168 Cluster_537437 V1251324 S radical SAM domain protein COG0641 Cluster_537438 V1251325 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_537439 V1251326 P Arylsulfatase COG3119 Cluster_537440 V1251327 HEMN map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_537441 V1251328 TNAA map00350,map00380 E tryptophanase EC 4.1.99.1 COG3033 Cluster_537442 V1251330 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins COG0706 Cluster_537443 V1251331 PHOR map02020 T Histidine kinase 0XNMH Cluster_537444 V1251332 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_537446 V1251335 CASB S CRISPR system CASCADE complex protein CasB 0ZXJT Cluster_692242 V1251336 S NA 180G3@proNOG Cluster_840199 V1251338 S NA 11KFV Cluster_618049 V1251340 S Phage portal protein, SPP1 Gp6-like 11J8D Cluster_537447 V1251341 THIH map00730,map01100 H biosynthesis protein thiH COG1060 Cluster_537448 V1251342 YCAM E amino acid COG0531 Cluster_606954 V1251345 SPEA map00330,map01100 E Catalyzes the biosynthesis of agmatine from arginine (By similarity) COG1166 Cluster_699308 V1251346 S copper amine 121X1 Cluster_537450 V1251347 S NA 101UU Cluster_537451 V1251348 SP_1221 V restriction 0XQ8K Cluster_537452 V1251350 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_537453 V1251351 THRC map00260,map00750,map01100,map01120,map01230 E Threonine synthase COG0498 Cluster_537454 V1251352 S Organic solvent tolerance protein 0XQ3B Cluster_641059 V1251353 PAP L polyphosphate kinase 2 COG2326 Cluster_692243 V1251354 RLPB M Rare lipoprotein B COG2980 Cluster_537455 V1251355 S domain protein 12C1H Cluster_573315 V1251356 G Major Facilitator COG2814 Cluster_537456 V1251357 OATA I Acyl-transferase COG1835 Cluster_537457 V1251358 S Inherit from NOG: domain protein 0XQ9I Cluster_540230 V1251360 S NA 11W22 Cluster_824843 V1251362 V Mate efflux family protein COG0534 Cluster_777485 V1251363 map03420,map03430 L helicase COG0210 Cluster_537459 V1251365 map02010 V ABC-2 type transporter COG0842 Cluster_537460 V1251367 T two component transcriptional regulator, arac family 11GD4 Cluster_537461 V1251368 S NA 0Y91I Cluster_599738 V1251369 S peptidase C10 11SDT Cluster_641060 V1251370 S Chromosome segregation ATPase 0XTFW Cluster_661434 V1251371 S NA 11K71 Cluster_540231 V1251372 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_641061 V1251373 T Histidine kinase 0XNMH Cluster_586093 V1251375 S NA 0YBQM Cluster_864024 V1251376 map02010 V ABC, transporter COG1131 Cluster_725015 V1251377 S NA 11GQ4 Cluster_540232 V1251378 PHNC map02010 P phosphonate abc transporter COG3638 Cluster_606955 V1251381 RDGB map00230,map00240,map01100 F Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) COG0127 Cluster_540233 V1251384 PEP E prolyl oligopeptidase COG1505 Cluster_537462 V1251387 AGCS E amino acid carrier protein COG1115 Cluster_576540 V1251388 V type III restriction system methylase 0Z5FE Cluster_809285 V1251389 YHBE E, G Membrane COG0697 Cluster_592763 V1251392 GLCK map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G ROK family COG1940 Cluster_884270 V1251393 M nlpC P60 family protein COG0791 Cluster_734814 V1251394 S NA 11Z2S Cluster_537463 V1251395 EUTE map00010,map00071,map00350,map00362,map00620,map00621,map00622,map00625,map00626,map00650,map01100,map01110,map01120 C Dehydrogenase COG1012 Cluster_715084 V1251396 U TraG family COG3505 Cluster_540234 V1251397 U TraG family COG3505 Cluster_540235 V1251398 G hydrolase family 2, sugar binding COG3250 Cluster_589385 V1251399 FRDD map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020 C Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) COG3080 Cluster_540236 V1251400 SUCD map00020,map00640,map00660,map00720,map01100,map01110,map01120 C Succinyl-CoA ligase ADP-forming subunit alpha COG0074 Cluster_692244 V1251401 V restriction COG1002 Cluster_540237 V1251403 O cysteine protease COG4870 Cluster_540238 V1251407 THIH map00730,map01100 H biosynthesis protein thiH COG1060 Cluster_540240 V1251409 HUTU map00340,map01100 E Urocanate hydratase COG2987 Cluster_801068 V1251410 ATPA map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_785350 V1251411 ATPG map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) COG0224 Cluster_687759 V1251413 MSRR K TRANSCRIPTIONal COG1316 Cluster_540241 V1251414 SFUB map02010 P transporter (permease) COG1178 Cluster_715085 V1251416 PYRR map00240,map01100 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) COG2065 Cluster_855676 V1251418 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_718343 V1251419 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_711707 V1251420 DAM map03430 L Dna adenine methylase COG0338 Cluster_586094 V1251421 V N-6 DNA Methylase COG0286 Cluster_543138 V1251422 K RNA Polymerase COG0086 Cluster_641062 V1251423 LACE map00052,map01100,map02060 G pts system, lactose-specific COG1455 Cluster_543140 V1251426 CZCD P cation diffusion facilitator family transporter COG0053 Cluster_540242 V1251427 S Ragb susd domain-containing protein 0XPXH Cluster_540243 V1251428 S chromosome segregation ATPase-like protein 0XQH8 Cluster_543141 V1251429 S oxidoreductase 0XP5M Cluster_793140 V1251431 L DNA mismatch repair protein COG0249 Cluster_674323 V1251432 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_582901 V1251433 map02020 T Histidine kinase 0XNMH Cluster_540244 V1251435 K Transcriptional regulator, GntR family COG1725 Cluster_563838 V1251436 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_718344 V1251437 L Inherit from NOG: transposase 11VUP Cluster_551996 V1251439 MIAB J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) COG0621 Cluster_696018 V1251440 FUCA map00040,map00051,map01100 G Class II aldolase adducin family protein COG0235 Cluster_543142 V1251441 HLY map00270,map00450,map00920,map01100,map01110,map01230 E Aminotransferase class I and II COG1168 Cluster_543143 V1251442 MREB D Rod shape-determining protein mreb COG1077 Cluster_665658 V1251444 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_644944 V1251446 TNPX L Site-specific recombinase COG1961 Cluster_540245 V1251447 M (sortase) family COG3764 Cluster_540246 V1251448 CCMG O Thiol disulfide interChange protein COG0526 Cluster_557803 V1251451 S DNA primase COG3378 Cluster_540248 V1251452 SERC map00260,map00680,map00750,map01100,map01120,map01230 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) COG1932 Cluster_770079 V1251453 RPIB map00030,map00710,map01100,map01110,map01120,map01230 G Ribose/Galactose Isomerase COG0698 Cluster_543145 V1251454 TIG O Peptidyl-prolyl cis-trans isomerase COG0545 Cluster_543146 V1251455 S Prophage Lp2 protein 4 11JSF Cluster_543147 V1251456 MNME S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 Cluster_540249 V1251457 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_543148 V1251458 S NA 11HVH Cluster_625492 V1251460 S NA 0XVGU Cluster_731588 V1251461 RPSQ map03010 J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal COG0186 Cluster_543149 V1251463 GLTA map00250,map00910,map01100,map01110,map01120,map01230 E Glutamate synthase COG0543 Cluster_751639 V1251465 NHAC map00680 C Na H antiporter COG1757 Cluster_855677 V1251466 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate (By similarity) COG0167 Cluster_725017 V1251467 PYRK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) COG0543 Cluster_543150 V1251468 TNPX L Resolvase COG1961 Cluster_543151 V1251469 P tonB-dependent Receptor 0XNN9 Cluster_543152 V1251471 map00051,map00363,map00520,map00591,map00625,map00650,map01100,map01120 M Dehydrogenase COG0677 Cluster_657232 V1251472 S DNA-binding helix-turn-helix protein 0ZJRR Cluster_543153 V1251473 LGAS_0606 S Phage Portal Protein 0XP33 Cluster_543155 V1251476 map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_543156 V1251477 GLOB map00620 C Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) COG0491 Cluster_725018 V1251478 S thioesterase Superfamily protein 11IYE Cluster_543157 V1251480 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_543158 V1251481 S Nucleotidyl transferase of unknown function (DUF1814) 0XP6B Cluster_543159 V1251482 PLSC map00561,map00564,map01100 I Acyl-transferase COG0204 Cluster_543160 V1251483 NUON map00190,map00910,map01100 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) COG1007 Cluster_573316 V1251484 YHGE S Membrane 176P0@proNOG Cluster_718345 V1251486 SFSA L Sugar fermentation stimulation protein homolog COG1489 Cluster_543161 V1251487 RIBF map00740,map01100 H riboflavin biosynthesis protein ribF COG0196 Cluster_543162 V1251488 RIBU S Membrane COG3601 Cluster_573317 V1251489 RPSG map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) COG0049 Cluster_546077 V1251492 P tonB-dependent Receptor COG1629 Cluster_848119 V1251494 TLL0478 L NA 0XX6M Cluster_567032 V1251500 LPTB map02010 S ABC transporter COG1137 Cluster_546078 V1251501 DEOB map00030,map00230 G Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) COG1015 Cluster_543167 V1251502 KDGK map00030,map00040,map01100,map01120 G pfkb domain protein COG0524 Cluster_543168 V1251503 ZUPT P Mediates zinc uptake. May also transport other divalent cations (By similarity) COG0428 Cluster_543169 V1251504 S NA 0YWBS Cluster_543170 V1251505 M Outer membrane efflux protein 0XQFG Cluster_582903 V1251506 GLPA map00564 C anaerobic glycerol-3-phosphate dehydrogenase, subunit A COG0578 Cluster_543171 V1251507 PROC map00330,map01100,map01110,map01230 E pyrroline-5-carboxylate reductase COG0345 Cluster_813279 V1251509 D cell division protein FtsK COG1674 Cluster_851901 V1251510 map00053,map01100,map01120,map02060 G Phosphoenolpyruvate-dependent sugar phosphotransferase system, eiia 2 COG1762 Cluster_543172 V1251511 MUTL map03430 L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) COG0323 Cluster_543173 V1251512 RECG map03420,map03440 L ATP-dependent DNA helicase recg COG1200 Cluster_546079 V1251513 N, U Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase COG1705 Cluster_603326 V1251514 RNR map03018 K ribonuclease COG0557 Cluster_543174 V1251515 S NA 0XQVA Cluster_543175 V1251516 SPPA O, U Signal peptide peptidase, SppA COG0616 Cluster_546080 V1251518 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_543176 V1251523 DNAC L DNA replication protein COG1484 Cluster_586095 V1251524 LACG map00052,map01100 G Glycosyl hydrolase family 1 COG2723 Cluster_637078 V1251525 YBBP S TIGR00159 family COG1624 Cluster_546082 V1251526 M NA 0ZY8Y Cluster_546083 V1251527 ECSA map02010 V Abc transporter COG1131 Cluster_543177 V1251528 PNTB map00760,map01100 C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) COG1282 Cluster_546084 V1251529 S abc transporter atp-binding protein 11J2E Cluster_546085 V1251530 S phage terminase large subunit 0ZCYP Cluster_748215 V1251532 PHOP map02020 T Two component transcriptional regulator (Winged helix family 11FPD Cluster_653092 V1251533 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_546086 V1251534 FDOH map00630,map00680,map01100,map01120,map02020 C formate dehydrogenase COG0437 Cluster_546087 V1251535 YGJR map00051,map00363,map00591,map00625,map00650,map01100,map01120 G oxidoreductase COG0673 Cluster_546088 V1251536 S Tetratricopeptide repeat protein 11FUM Cluster_546089 V1251537 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_579656 V1251538 P hemerythrin hhe cation binding domain protein COG2461 Cluster_621698 V1251539 ADCA map02010 P periplasmic solute binding protein COG0803 Cluster_546090 V1251540 map02010 S permease yjgp yjgq COG0795 Cluster_546091 V1251541 M outer membrane chaperone Skp (OmpH) 11PTW Cluster_546092 V1251542 M Nucleoside-diphosphate-sugar pyrophosphorylase 0ZRVF Cluster_905055 V1251543 S NA 0Y1MD Cluster_836288 V1251545 RPST map03010 J Binds directly to 16S ribosomal RNA (By similarity) COG0268 Cluster_546093 V1251548 K Transcriptional regulator (AsnC family) COG1522 Cluster_586096 V1251549 YLBB V abc transporter permease protein COG0577 Cluster_546094 V1251554 RSEP map04112 M Membrane-associated zinc metalloprotease COG0750 Cluster_546095 V1251555 METY map00270,map00450,map00920,map01100,map01110,map01230 E Cys/Met metabolism PLP-dependent enzyme COG2873 Cluster_546096 V1251556 V abc transporter permease protein 0XQE2 Cluster_805255 V1251557 S TraX protein 11N9P Cluster_546098 V1251559 L TatD-related deoxyribonuclease COG0084 Cluster_546099 V1251560 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_699309 V1251561 FTSQ map04112 S cell division protein 11KRI Cluster_900756 V1251562 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_549121 V1251563 S NA 0YB9V Cluster_546100 V1251564 METI map02010 P ABC transporter, permease COG2011 Cluster_546101 V1251565 M Glycosyl transferase (Group 1 0XSCX Cluster_603328 V1251567 YHBW C Luciferase family COG2141 Cluster_551997 V1251569 ZITB P cation diffusion facilitator family transporter COG1230 Cluster_546102 V1251570 S tetratricopeptide repeat 0YK8K Cluster_582904 V1251572 CDD map00240,map00983,map01100,map05219 F cytidine deaminase COG0295 Cluster_546103 V1251574 LACZ map00052,map00511,map00600,map01100 G Glycoside hydrolase family 2 TIM barrel COG3250 Cluster_546104 V1251575 PSTA map02010 P phosphate abc transporter COG0581 Cluster_637079 V1251576 map02020,map03070 U Prokaryotic N-terminal methylation motif 0ZR0Y Cluster_637080 V1251577 SIGB K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG1191 Cluster_546105 V1251578 P TonB-dependent receptor 1AI9D@sphNOG Cluster_674326 V1251579 RUMAL_0348 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_549122 V1251580 UDK map00240,map00983,map01100 F uridine kinase COG0572 Cluster_789369 V1251582 S NA 0ZXT9 Cluster_546106 V1251584 CSN1 L crispr-associated protein COG3513 Cluster_546107 V1251585 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_744863 V1251586 S NA 127P1 Cluster_828647 V1251587 RPLE map03010 J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COG0094 Cluster_832399 V1251588 S NA 1261E Cluster_705472 V1251589 YLXM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) COG2739 Cluster_678773 V1251593 RIBA map00740,map01100 H Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) COG0807 Cluster_546108 V1251595 S (LipO)protein 11J26 Cluster_683321 V1251596 S NA 11P0I Cluster_549124 V1251597 RFAG map00051 M glycosyltransferase group 2 family protein COG0463 Cluster_573318 V1251598 OPPB map02010 P ABC transporter (permease) COG0601 Cluster_777487 V1251599 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_731589 V1251600 G Glycoside Hydrolase Family 43 0ZW8V Cluster_665659 V1251603 PPAC map00190 C Manganese-dependent inorganic pyrophosphatase COG1227 Cluster_546109 V1251605 HRPA L ATP-dependent helicase COG1643 Cluster_567033 V1251606 DAPA map00300,map01100,map01110,map01120,map01230 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) COG0329 Cluster_549125 V1251608 MTAD F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) COG0402 Cluster_546110 V1251609 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_546111 V1251610 MLTD M Lytic Murein transglycosylase COG0741 Cluster_592765 V1251611 C flavodoxin family COG0716 Cluster_549126 V1251617 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_921620 V1251619 YLMH J s4 domain protein COG2302 Cluster_708554 V1251620 S diviva domain 126CA Cluster_549127 V1251621 ATPF map00190,map00195,map01100 C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) COG0711 Cluster_549128 V1251622 S copper amine 121X1 Cluster_549129 V1251625 T Histidine kinase COG0642 Cluster_669941 V1251626 SERA map00260,map00680,map01100,map01120,map01230 C dehydrogenase COG0111 Cluster_603329 V1251627 DCTP C symporter COG1301 Cluster_549130 V1251628 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit alpha COG0587 Cluster_549131 V1251630 YAAO map00310,map00330,map00960,map01100,map01110 E decarboxylase COG1982 Cluster_549133 V1251633 TYPA T gtp-binding protein typa COG1217 Cluster_596239 V1251636 RPIB map00030,map00052,map00710,map01100,map01110,map01120,map01230 G isomerase COG0698 Cluster_549135 V1251639 S NA 0ZPIA Cluster_549136 V1251641 S UPF0597 protein COG3681 Cluster_549137 V1251643 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_549138 V1251644 RNFC C Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) COG4656 Cluster_549139 V1251645 HEPT map00900,map01110 H synthase COG0142 Cluster_755105 V1251647 FEPC map02010 P ABC, transporter COG1120 Cluster_683322 V1251648 K Transcriptional regulator, TetR family 11JD6 Cluster_549140 V1251649 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_551999 V1251656 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_549141 V1251657 PLSY map00561,map00564,map01100 S Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) COG0344 Cluster_718346 V1251660 YAJC map03060,map03070 U preprotein translocase, subunit YajC COG1862 Cluster_715087 V1251662 OPPCD E, P abc transporter COG1173 Cluster_552000 V1251663 RECG map03440 L ATP-dependent DNA helicase recG COG1200 Cluster_549143 V1251664 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_683323 V1251666 map00230 S phosphorylase 11F11 Cluster_549144 V1251668 PARE L Dna topoisomerase iv (Subunit b) COG0187 Cluster_549145 V1251669 TIG O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COG0544 Cluster_718347 V1251673 S RelB antitoxin 0YV3D Cluster_549146 V1251674 ISPA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_549147 V1251675 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_552001 V1251677 AMIB map00360 E amidohydrolase EC COG1473 Cluster_552002 V1251678 NIFU C May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins COG0822 Cluster_809289 V1251679 V type I restriction enzyme 11IAT Cluster_884273 V1251680 O DnaJ domain protein COG1076 Cluster_560851 V1251683 map02010 P cobalt transport COG0619 Cluster_606956 V1251684 map00230 S Metal Dependent Phosphohydrolase 11UWJ Cluster_751641 V1251685 LYTR2 K TRANSCRIPTIONal COG1316 Cluster_711708 V1251687 CYSE map00270,map00920,map01100,map01120,map01230 E serine acetyltransferase COG1045 Cluster_683324 V1251688 HCAT G Major Facilitator superfamily 16SGU@proNOG Cluster_552003 V1251690 PYC map00020,map00620,map00720,map01100,map01120,map01230 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) COG1038 Cluster_661436 V1251691 DNAJ O DnaJ domain protein COG0484 Cluster_669942 V1251692 S NA 11I0V Cluster_661437 V1251693 CUTC P copper homeostasis protein cutc COG3142 Cluster_552004 V1251694 NORV map05132 C uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center COG0426 Cluster_552006 V1251697 ACTP P p-type atpase COG2217 Cluster_738156 V1251698 AAER K Transcriptional regulator 16T3R@proNOG Cluster_552007 V1251699 PAAG I Enoyl-CoA hydratase COG1024 Cluster_552008 V1251700 S NA 0YBNW Cluster_552009 V1251701 NAGA map00052,map00520,map01110 G GlcNAc 6-P deacetylase COG1820 Cluster_606957 V1251702 P transporter COG0471 Cluster_552010 V1251705 TIG O Trigger factor COG0544 Cluster_552011 V1251706 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_552012 V1251707 V restriction enzyme COG1002 Cluster_552013 V1251708 GALR K Transcriptional regulator COG1609 Cluster_633033 V1251709 TNP L transposase COG1943 Cluster_552014 V1251710 S YycH protein 12BVJ Cluster_552015 V1251711 HEMN map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_552016 V1251712 FTSK D cell division protein FtsK COG1674 Cluster_552017 V1251713 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_618050 V1251714 K, L domain protein COG0553 Cluster_552018 V1251717 RSMI G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 Cluster_669943 V1251718 YQJG O Glutathione S-transferase COG0435 Cluster_741579 V1251719 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG1214 Cluster_932235 V1251720 S NA 11FDB Cluster_552019 V1251721 YOJN S ATPase associated with various cellular activities aaa_5 COG0714 Cluster_728294 V1251722 RNC map03008,map05205 K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) COG0571 Cluster_552020 V1251723 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_552021 V1251724 G Glycosyl hydrolase family 92 COG3537 Cluster_552022 V1251726 AMT P ammonium transporter COG0347 Cluster_552023 V1251727 S (LipO)protein 0XSV5 Cluster_552024 V1251728 AGMN S NA 0XQ4M Cluster_554897 V1251732 L Phage integrase family protein 17K03@proNOG Cluster_848120 V1251734 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_552025 V1251735 SAGG map02010 V ABC transporter, ATP-binding protein COG1131 Cluster_554899 V1251737 T response regulator COG0745 Cluster_820874 V1251738 J acetyltransferase, (GNAT) family COG1670 Cluster_552026 V1251739 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_552027 V1251740 TTHE_0913 L Transposase (IS4 family 0XPUE Cluster_552028 V1251742 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG0194 Cluster_579657 V1251743 RIMP S Required for maturation of 30S ribosomal subunits (By similarity) COG0779 Cluster_718348 V1251744 PTS-EIIC map00051,map00520,map01100,map02060 G PTS System COG3715 Cluster_653094 V1251748 RPLC map03010 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 Cluster_563839 V1251749 S Protein of unknown function (DUF2023) 11U1H Cluster_554900 V1251750 GAP map00010,map01100,map01110,map01120,map01230,map04066,map05010 G Glyceraldehyde-3-phosphate dehydrogenase COG0057 Cluster_603330 V1251751 map00561,map01100 M Glycosyl transferase (Group 1 COG0438 Cluster_552030 V1251753 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_554901 V1251754 map03440 K Transcriptional regulator COG2865 Cluster_567034 V1251755 GPMB map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_552031 V1251757 RECB L recb family COG2887 Cluster_836289 V1251760 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_554902 V1251762 WECG M Glycosyl transferase, wecb taga cpsf family COG1922 Cluster_824845 V1251763 RNFD C Electron transport complex COG4658 Cluster_770080 V1251764 C Electron transport complex, RnfABCDGE type, G subunit 0XXUW Cluster_721649 V1251766 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_641063 V1251767 S conserved domain protein 0YAQR Cluster_554903 V1251768 DAPE map00300,map00330,map01100,map01110,map01120,map01210,map01230 E Acetylornithine deacetylase COG0624 Cluster_880113 V1251769 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_699312 V1251770 map00770,map01100 H Pantothenate kinase 109YT Cluster_554904 V1251771 APBE H ApbE family COG1477 Cluster_554905 V1251773 P receptor 0XNZF Cluster_552033 V1251774 S Oligopeptide transporter, Opt family COG1297 Cluster_644945 V1251775 V Beta-lactamase COG1680 Cluster_596240 V1251776 S domain protein 11PT0 Cluster_718349 V1251777 S Protein of unknown function (DUF2750) 11R1C Cluster_554906 V1251778 S NA 11NIP Cluster_554907 V1251779 PLSY map00561,map00564,map01100 S Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) COG0344 Cluster_657233 V1251780 CCA map03013,map03018 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate COG0617 Cluster_554908 V1251781 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_576541 V1251783 ALGI M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_554909 V1251784 NADB map00250,map00760,map01100 H L-aspartate oxidase COG0029 Cluster_625493 V1251786 FLDA map00960 C L-carnitine dehydratase bile acid-inducible protein F COG1804 Cluster_678774 V1251787 RV1042C L Transposase COG3293 Cluster_554910 V1251789 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_554911 V1251790 SERP0565 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_554912 V1251791 S NA 0YB2E Cluster_554913 V1251792 RSMG M Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) COG0357 Cluster_554914 V1251793 ANSA map00250,map00460,map00910,map01100,map01110 E l-asparaginase (EC 3.5.1.1) COG0252 Cluster_625494 V1251794 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG2812 Cluster_880114 V1251795 ADD map00230,map01100,map05340 F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) COG1816 Cluster_554915 V1251798 S ATPase (AAA COG1373 Cluster_557804 V1251799 LPLA map00785,map01100 H Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) COG0095 Cluster_557805 V1251800 HGDB E dehydratase COG1775 Cluster_390822 V1025001 S (phospho)adenosine phosphosulfate reductase 17TNC@proNOG Cluster_533768 V1025003 E HAD-superfamily subfamily IB hydrolase COG0560 Cluster_392605 V1025004 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin 0XQTW Cluster_392607 V1025009 NRDF map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_424790 V1025012 ATPB map00190,map00195,map01100 C it plays a direct role in the translocation of protons across the membrane (By similarity) COG0356 Cluster_862984 V1025014 TRXA O Thioredoxin COG0526 Cluster_704632 V1025015 S Thioesterase 11UBJ Cluster_656184 V1025019 ACDS map00270,map00640 E 1-aminocyclopropane-1-carboxylate deaminase COG2515 Cluster_392609 V1025025 P Heavy metal efflux pump, CzcA COG3696 Cluster_660331 V1025027 RPLD map03010 J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) COG0088 Cluster_677648 V1025028 RPLW map03010 J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) COG0089 Cluster_392610 V1025037 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_394358 V1025040 ECFA1 map02010 P abc transporter COG1122 Cluster_394359 V1025041 GSPE map03070 U type II secretion system protein E COG2804 Cluster_533769 V1025044 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_394361 V1025045 PDHD map00010,map00020,map00260,map00280,map00620,map01100,map01110,map01120 C dihydrolipoyl dehydrogenase COG1249 Cluster_647927 V1025047 MIHF S integration host factor 11UU9 Cluster_394363 V1025050 SCLAV_2230 V ABC, transporter COG0577 Cluster_394364 V1025051 S Protein of unknown function (DUF3304) 17TD7@proNOG Cluster_727378 V1025052 SOJ D cobyrinic Acid a,c-diamide synthase COG1192 Cluster_551269 V1025055 S NA 0YIA5 Cluster_428593 V1025056 YHCD map05133 M usher protein( 16QS5@proNOG Cluster_652018 V1025059 S NA 0ZHU9 Cluster_727379 V1025061 RPST map03010 J (ribosomal) protein COG0268 Cluster_396215 V1025065 COPB P copper resistance COG3667 Cluster_750740 V1025067 TESA map01040 E acyl-CoA thioesterase i COG2755 Cluster_396218 V1025069 MGTE P MgtE intracellular region COG2239 Cluster_397957 V1025071 HEMG map00860,map01100,map01110 H protoporphyrinogen oxidase COG1232 Cluster_776555 V1025073 PGM map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_396219 V1025075 D ec 3.6.3.16 COG0003 Cluster_401412 V1025076 EBA2484 L AtP-binding protein COG1484 Cluster_639991 V1025079 S NA 0ZHU9 Cluster_486789 V1025080 map02010 E amino acid COG0683 Cluster_858493 V1025083 S NA 0ZHU9 Cluster_578774 V1025085 RPSL map03010 J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) COG0048 Cluster_396220 V1025086 NIRA map00910,map00920,map01100,map01120 C Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) COG0155 Cluster_397959 V1025088 S NA 0XPYX Cluster_494062 V1025089 PBUG S Xanthine uracil vitamin C permease COG2252 Cluster_812245 V1025094 METF map00670,map00720,map01100,map01120 E Methylenetetrahydrofolate reductase COG0685 Cluster_477460 V1025095 TRMB C Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_428594 V1025098 GLNA map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG0174 Cluster_643909 V1025099 ZAPA S Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) COG3027 Cluster_397960 V1025100 S alpha-2-macroglobulin COG2373 Cluster_397961 V1025101 U, W Inherit from COG: domain protein 121KM Cluster_496556 V1025103 HLB map00562,map00564,map00565,map00600,map01100 G Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) 0ZQ24 Cluster_471002 V1025105 YGJP S metal-dependent hydrolase COG1451 Cluster_499207 V1025108 GLTT E glutamate COG0786 Cluster_399656 V1025110 GLK map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G glucokinase COG1940 Cluster_397962 V1025112 L Terminase, large subunit COG5525 Cluster_399657 V1025115 V Type III COG3587 Cluster_916707 V1025118 BMUL_3319 Q DSBA oxidoreductase COG3917 Cluster_482161 V1025119 ATOA map00072,map00280,map00627,map00640,map00650,map01100,map01120,map02020 I CoA-transferase subunit B COG2057 Cluster_399658 V1025120 V Inherit from COG: Type II restriction enzyme, methylase COG1002 Cluster_399659 V1025123 LPTB map02010 S ABC transporter COG1137 Cluster_440538 V1025124 YCSE S hydrolase COG0561 Cluster_664543 V1025125 NIRD map00910,map01120 C nitrite reductase (NAD(P)h) small subunit COG2146 Cluster_419295 V1025126 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_479832 V1025128 YODF E na solute symporter COG0591 Cluster_904035 V1025129 BMUL_0939 S integral membrane protein 17RHF@proNOG Cluster_399660 V1025130 NUOL map00190,map00910,map01100 C subunit L COG1009 Cluster_399661 V1025131 CKL_1870 S phage terminase large subunit 0XSCY Cluster_401413 V1025132 T Histidine kinase 0ZPYN Cluster_399662 V1025133 J ribosome-associated inhibitor protein Y COG1544 Cluster_401414 V1025134 S tetratricopeptide repeat 0ZZIS Cluster_733945 V1025138 DIND S DNA-damage-inducible protein d 0XQQP Cluster_854705 V1025139 DIND S DNA-damage-inducible protein d 0XQQP Cluster_460471 V1025140 LYSM S Lysm domain protein 12BED Cluster_399663 V1025141 V restriction endonuclease COG0827 Cluster_548296 V1025142 MAMA map00280,map00640,map00660,map00720,map01100,map01120 E Glutamate mutase subunit sigma COG2185 Cluster_639992 V1025143 COAD map00770,map01100 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) COG0669 Cluster_765321 V1025144 C Inherit from NOG: 4fe-4S ferredoxin iroN-sulfur binding 171UN@proNOG Cluster_401416 V1025148 CCRB L Resolvase COG1961 Cluster_514534 V1025150 PGN_0048 S NA 0YI97 Cluster_796131 V1025152 PROB map00330,map01100,map01230 E Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) COG0263 Cluster_727380 V1025153 S NA 17BRQ@proNOG Cluster_686569 V1025154 S NA 17W8V@proNOG Cluster_401417 V1025158 UVRD2 map03420,map03430 L helicase COG2887 Cluster_401418 V1025161 BMUL_0554 G Major facilitator superfamily 16S8F@proNOG Cluster_643910 V1025164 S NA 17QUF@proNOG Cluster_737216 V1025165 DBPA map03018 L ATP-dependent RNA helicase DbpA COG0513 Cluster_879036 V1025166 YGGP map00051,map00363,map00591,map00625,map00650,map01100,map01120 E Alcohol dehydrogenase zinc-binding domain protein COG1063 Cluster_401420 V1025167 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_403194 V1025168 U hemolysin activation secretion protein COG2831 Cluster_442557 V1025171 AAPM map02010,map02020 E amino acid AbC transporter COG0765 Cluster_727381 V1025172 S NA 0Z34Z Cluster_471003 V1025174 RBTT G Alpha-ketoglutarate permease COG0477 Cluster_403195 V1025176 S GSCFA domain protein 0YSVQ Cluster_401421 V1025177 P tonB-dependent Receptor COG4206 Cluster_750741 V1025178 INSG L transposase (IS4 family) protein COG3385 Cluster_401422 V1025181 CUSA map02020 P Heavy metal efflux pump, CzcA COG3696 Cluster_517256 V1025183 G YhcH YjgK YiaL family protein COG2731 Cluster_477461 V1025187 PGMA S OmpA family 11HEJ Cluster_403196 V1025188 CYSW map02010 P sulfate abc transporter COG4208 Cluster_403197 V1025189 S PriCT_1 11P4Z Cluster_403198 V1025190 HPAB map00350,map00650,map00720,map01120 Q 4-hydroxyphenylacetate COG2368 Cluster_403199 V1025193 M domain protein 11EAB Cluster_686570 V1025194 MAF D MAF-like protein COG0424 Cluster_578775 V1025195 YQJI K Transcriptional regulator COG1695 Cluster_557807 V1251804 S NA 11V3D Cluster_554916 V1251806 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_554918 V1251808 NHAC map00680 C Na H antiporter COG1757 Cluster_641064 V1251809 METN map02010 P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COG1135 Cluster_554919 V1251810 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_554920 V1251811 T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase COG2972 Cluster_766362 V1251813 AGAS M isomerase COG2222 Cluster_557808 V1251817 P ATPase, P-type transporting, HAD superfamily, subfamily IC COG0474 Cluster_560852 V1251818 YFCE S Phosphodiesterase COG0622 Cluster_832401 V1251819 RPH map00230,map00240,map01100 J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) COG0689 Cluster_773762 V1251822 LSRK G Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) COG1070 Cluster_554921 V1251823 SERA2 map00260,map00680,map01100,map01120,map01230 E Dehydrogenase COG0111 Cluster_702363 V1251828 BGLF map00010,map00500,map00520,map02060 G PTS system beta-glucoside-specific transporter subunit IIABC COG2190 Cluster_557810 V1251829 ARDC L antirestriction protein COG4227 Cluster_554922 V1251831 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_570106 V1251832 S NA 11W3X Cluster_738157 V1251835 K Transcriptional regulator, arsr family COG0640 Cluster_888188 V1251838 ISPF map00900,map01100,map01110 I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) COG0245 Cluster_718351 V1251839 ISPD map00900,map01100,map01110 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COG1211 Cluster_557813 V1251840 map00020,map00300,map00630,map00720,map01100,map01110,map01120,map01210,map01230 C aconitate hydratase COG1048 Cluster_744865 V1251843 ATPE map00190,map00195,map01100 C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) 0ZX31 Cluster_557814 V1251844 PGLF M epimerase dehydratase COG1086 Cluster_557815 V1251847 L plasmid recombination enzyme 0ZWBR Cluster_554923 V1251849 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_576542 V1251850 RPLK map03010 J This protein binds directly to 23S ribosomal RNA (By similarity) COG0080 Cluster_557816 V1251851 S relaxase mobilization nuclease domain protein 0XNXG Cluster_557818 V1251853 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_557821 V1251856 TAL map00030,map01100,map01110,map01120,map01230 G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) COG0176 Cluster_741580 V1251857 SERA map00260,map00680,map01100,map01120,map01230 E, H Dehydrogenase COG0111 Cluster_557822 V1251858 CAS3 L CRISPR-Associated Helicase Cas3 COG1203 Cluster_683325 V1251859 PACL P p-type ATPase COG0474 Cluster_637081 V1251860 S NA 11QQ0 Cluster_557823 V1251861 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_573320 V1251862 map00190,map00910,map01100 C hydrogenase) (Fe-only COG4624 Cluster_848123 V1251864 RSMG M Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) COG0357 Cluster_687762 V1251865 S PglZ domain protein 0XQ4Q Cluster_557824 V1251866 T Histidine kinase COG5002 Cluster_557825 V1251867 RBSR K Transcriptional regulator COG1609 Cluster_557826 V1251868 RFBA map00521,map00523,map01100,map01110 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) COG1209 Cluster_557829 V1251872 YQEV J MiaB-like tRNA modifying enzyme COG0621 Cluster_665660 V1251873 VIRB4 map03070,map05120 U conjugal transfer ATPase COG3451 Cluster_661440 V1251874 P TonB dependent receptor 0XNNV Cluster_557830 V1251875 ACDA map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I acyl-CoA dehydrogenase COG2025 Cluster_557831 V1251876 LACI K lac repressor COG1609 Cluster_560853 V1251878 PHOU P Plays a role in the regulation of phosphate uptake COG0704 Cluster_715088 V1251879 map03440 K Transcriptional regulator COG2865 Cluster_557832 V1251882 PEPS E aminopeptidase COG2309 Cluster_560854 V1251884 PBUG S Xanthine uracil vitamin C permease COG2252 Cluster_560855 V1251885 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_665661 V1251887 LON map04112 O ATP-dependent Lon protease COG4930 Cluster_560856 V1251888 HSDS V specificity COG0732 Cluster_633034 V1251892 PULA G Glycogen debranching enzyme COG1523 Cluster_606959 V1251894 S Helix-turn-helix 0YAU0 Cluster_557833 V1251895 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_817032 V1251896 O Peptidase M16 inactive domain protein COG0612 Cluster_905059 V1251897 PPIA O PPIases accelerate the folding of proteins COG0652 Cluster_641065 V1251899 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG0469 Cluster_557834 V1251900 S integral membrane protein 0XS1S Cluster_596241 V1251904 L Site-specific recombinases, DNA invertase Pin homologs 11XUI Cluster_859696 V1251905 ARSB P arsenicaL-resistance protein COG0798 Cluster_560858 V1251907 S anti-termination protein 17C9Z@proNOG Cluster_621699 V1251908 S NA 0Y91I Cluster_653095 V1251909 S osta family 0XUST Cluster_678775 V1251910 S Helix-turn-helix 0XT0B Cluster_755106 V1251911 TYRA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydrogenase COG0287 Cluster_557835 V1251913 YEGQ map05120 O Peptidase U32 COG0826 Cluster_570107 V1251914 S SusD family 103XH Cluster_809291 V1251917 S Enterobacterial protein of unknown function (DUF957) 184TB@proNOG Cluster_725019 V1251919 S NA 11VIT Cluster_560859 V1251920 T cyclic nucleotide-binding domain protein COG0664 Cluster_560860 V1251921 CLPB O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_921623 V1251922 YAZA L domain protein COG2827 Cluster_773764 V1251923 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_560861 V1251924 P TonB dependent receptor 0XNNV Cluster_557837 V1251925 V Type II restriction 0XSKF Cluster_699313 V1251927 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_824846 V1251928 PLSX map00561,map00564,map01100 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) COG0416 Cluster_777489 V1251929 ACPP I Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) COG0236 Cluster_702365 V1251932 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_560862 V1251933 RNZ map03013 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) COG1234 Cluster_618052 V1251935 THIF map00730,map01100,map04122 H uba thif-type nad fad binding protein COG0476 Cluster_641066 V1251937 map00051 M Glycosyl transferase, family 2 COG1215 Cluster_560863 V1251938 SRTB U sortase, SrtB family COG4509 Cluster_557840 V1251939 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily COG1368 Cluster_661441 V1251940 K HTH_XRE 11IIE Cluster_610607 V1251941 HCP C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) COG1151 Cluster_741581 V1251942 PPNK map00760,map01100 G Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) COG0061 Cluster_748216 V1251943 S Protein of unknown function (DUF1294) COG3326 Cluster_560864 V1251946 RPLM map03010 J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) COG0102 Cluster_817034 V1251947 S tetratricopeptide 11P8K Cluster_653096 V1251948 PANC map00410,map00770,map01100,map01110 H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) COG0414 Cluster_793144 V1251949 YHCG S Conserved Protein COG4804 Cluster_560865 V1251950 SP_0899 S Membrane Associated 114SZ Cluster_560866 V1251951 NHAC map00680 C Na H antiporter COG1757 Cluster_560867 V1251952 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_599741 V1251953 ADDB L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination COG3857 Cluster_570108 V1251954 HSDM V Type I restriction-modification system, M subunit COG0286 Cluster_560868 V1251955 S NA 0Z34Z Cluster_560869 V1251956 S Inherit from NOG: Histidine triad protein 11G35 Cluster_741582 V1251957 map02020 T Histidine kinase COG0642 Cluster_560870 V1251959 Y0750 S Conserved Protein COG3586 Cluster_560871 V1251960 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_560872 V1251963 ISPE map00900,map01100,map01110 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COG1947 Cluster_614292 V1251965 YIHI S A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) COG3078 Cluster_606960 V1251968 S NA 0ZHU9 Cluster_560875 V1251969 map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_560877 V1251972 F Uracil permease COG2233 Cluster_560878 V1251976 Q Methyltransferase COG0500 Cluster_560879 V1251977 YIHQ map00052,map00500,map01100 G Alpha-glucosidase COG1501 Cluster_563840 V1251978 D cell division protein FtsK COG1674 Cluster_560880 V1251981 RPOD map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_560881 V1251983 map00520,map01110 G chitinase COG3325 Cluster_563841 V1251985 YXCA I coA-substrate-specific enzyme activase COG3581 Cluster_629180 V1251987 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_560883 V1251988 V ABC transporter transmembrane region COG1132 Cluster_560884 V1251989 UGE map00052,map00500,map00520,map01100,map01110 G, M Male sterility protein COG0451 Cluster_563842 V1251990 F Inherit from COG: deoxyguanosinetriphosphate triphosphohydrolase-like protein COG0232 Cluster_738158 V1251992 LRGB M lrgb family COG1346 Cluster_560885 V1251993 S Membrane 0XP2G Cluster_913378 V1251997 RPLC map03010 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 Cluster_705473 V1251998 RPLD map03010 J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) COG0088 Cluster_596242 V1251999 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_563844 V1252000 KORB map00020,map00720,map01100,map01120 C 2-oxoglutarate ferredoxin oxidoreductase subunit beta COG1013 Cluster_560886 V1252004 HTPG map04141,map04151,map04612,map04621,map04626,map04914,map04915,map05200,map05215 O Molecular chaperone. Has ATPase activity (By similarity) COG0326 Cluster_563845 V1252005 NADE map00760,map01100 H Nad synthetase COG0388 Cluster_563846 V1252006 S flavin reductase domain protein COG1853 Cluster_828650 V1252007 S Phage terminase small subunit COG3747 Cluster_563847 V1252012 MIND D site-determining protein COG2894 Cluster_563848 V1252013 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_696022 V1252015 S NA 0Z2EJ Cluster_560888 V1252016 MURE map00300,map00550 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_563851 V1252019 map00260,map01100 C pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_563852 V1252020 MUTY map03410 L a g-specific adenine glycosylase COG1194 Cluster_560889 V1252021 ISPG map00900,map01100,map01110 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) COG0821 Cluster_560890 V1252022 YKAA P phosphate transport regulator COG1392 Cluster_633036 V1252023 S integral membrane protein COG0392 Cluster_629181 V1252024 S -dicarboxylate symporter COG1823 Cluster_563853 V1252025 PEPP map00310,map00780,map01100 E peptidase M24 COG0006 Cluster_582905 V1252028 YBGQ map05133 M outer membrane usher protein COG3188 Cluster_721650 V1252029 FLGJ map00511 N, U flagellar rod assembly protein muramidase flgj COG1705 Cluster_718352 V1252030 S copper amine 121X1 Cluster_560891 V1252031 PUUP E amino acid COG0531 Cluster_563855 V1252032 YFGC map00310,map00780,map01100 O peptidase m48, ste24p COG4783 Cluster_563856 V1252035 NANA map00300,map00520,map01100,map01110,map01120,map01230 C Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate (By similarity) COG0329 Cluster_563857 V1252037 KIPI E Allophanate hydrolase, subunit 1 COG2049 Cluster_563858 V1252038 CLPA O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_563859 V1252040 SP_0791 map00051,map00363,map00591,map00625,map00650,map01100,map01120 C Aldo Keto reductase COG4989 Cluster_708556 V1252041 XERD L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_563860 V1252042 map00230,map00240,map00760,map01100,map01110 F 5'-nucleotidase COG0737 Cluster_563861 V1252043 M Inherit from COG: YD repeat protein COG3209 Cluster_563863 V1252045 UPPP map00550 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) COG1968 Cluster_813281 V1252046 ASP S Alkaline-shock protein COG1302 Cluster_563864 V1252048 NTPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_563865 V1252049 P TonB-dependent Receptor Plug Domain 0YD5U Cluster_674328 V1252050 S Conserved repeat domain protein 0XQ8S Cluster_563866 V1252051 TRAJ S conjugative transposon 0XP5P Cluster_567035 V1252053 XYLB map00040,map01100 G xylulokinase (EC 2.7.1.17) COG1070 Cluster_848124 V1252055 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_692248 V1252056 TYPA T gtp-binding protein typa COG1217 Cluster_669945 V1252057 TRXA O Thioredoxin COG0526 Cluster_696023 V1252059 YGBA S cytoplasmic protein 121K2 Cluster_567036 V1252060 LFERR_2229 map00680,map01100,map01120 S faD-dependent pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_563868 V1252061 RSGA G May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) COG1162 Cluster_567037 V1252063 M phosphoglycerol transferase COG1368 Cluster_567038 V1252064 RSEP map04112 M Membrane-associated zinc metalloprotease COG0750 Cluster_625496 V1252065 map02010 P abc-3 protein COG1108 Cluster_567039 V1252066 I protein, conserved in bacteria COG3581 Cluster_563869 V1252067 DPPD E, P (ABC) transporter COG0444 Cluster_797128 V1252068 S Ser Thr phosphatase family protein 11JEF Cluster_641067 V1252069 GALU map00040,map00052,map00500,map00520,map01100,map01110 M UTP-glucose-1-phosphate uridylyltransferase COG1210 Cluster_657235 V1252070 TDH G, M epimerase dehydratase COG0451 Cluster_567040 V1252071 map00230,map01100,map01110 F AICARFT/IMPCHase bienzyme COG0138 Cluster_563870 V1252073 GLPT map02020 G transporter COG2271 Cluster_563871 V1252074 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_567041 V1252075 PRFA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) COG0216 Cluster_563872 V1252076 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_586098 V1252077 LACC map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G tagatose-6-phosphate kinase COG1105 Cluster_563873 V1252078 ULAG map00053,map01100,map01120 S L-ascorbate 6-phosphate lactonase COG2220 Cluster_563874 V1252079 METG J emap domain COG0073 Cluster_755107 V1252080 S thioesterase Superfamily protein 11IYE Cluster_567042 V1252082 map00280,map00362,map00650,map01100,map01120 I glutaconyl-CoA decarboxylase COG4799 Cluster_563875 V1252084 SUSC P outer membrane protein SusC 0XNNV Cluster_836290 V1252086 PRMA J Methylates ribosomal protein L11 (By similarity) COG2264 Cluster_563876 V1252087 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_567043 V1252088 BDP_1102 V ABC transporter COG1136 Cluster_809292 V1252090 S Membrane COG3949 Cluster_567044 V1252092 M Glycosyl transferase family 2 COG0463 Cluster_699314 V1252093 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_563877 V1252097 YXCA I coA-substrate-specific enzyme activase COG3581 Cluster_576543 V1252098 LACE map00052,map01100,map02060 G Pts system COG1455 Cluster_625497 V1252101 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_567045 V1252105 PLPD S Patatin-like phospholipase COG1752 Cluster_699315 V1252107 M peptidase COG0739 Cluster_567046 V1252110 map03440 L UvrD REP helicase COG1074 Cluster_665662 V1252111 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_567047 V1252112 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_567048 V1252113 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_567049 V1252114 NIFJ map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map00910,map01100,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_567050 V1252115 S NA 0YXS4 Cluster_567053 V1252123 PURM map00230,map01100,map01110 F phosphoribosylaminoimidazole synthetase COG0150 Cluster_567054 V1252124 map00970 J prolyl-tRNA synthetase COG0442 Cluster_579659 V1252125 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_809293 V1252126 S Conjugative transposon TraK protein 11HQ1 Cluster_813282 V1252127 S NA 0YC2W Cluster_702366 V1252129 DXR map00900,map01100,map01110 I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) COG0743 Cluster_567056 V1252132 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_567058 V1252137 LTAE map00260,map01100,map01110,map01120,map01230 E Aldolase COG2008 Cluster_567059 V1252138 TRKA P potassium transporter peripheral membrane COG0569 Cluster_570109 V1252139 I CoA enzyme activase uncharacterised domain (DUF2229) COG3581 Cluster_567060 V1252140 REX K Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) COG2344 Cluster_567061 V1252141 L Integrase 11F4A Cluster_570110 V1252144 S NA 11FBZ Cluster_567062 V1252145 RBSR K Transcriptional regulator COG1609 Cluster_570111 V1252146 S NA 0YWSW Cluster_610608 V1252147 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_813283 V1252150 map03440 K Transcriptional regulator COG2865 Cluster_570112 V1252151 YGCE G sugar kinase ygcE COG1070 Cluster_621700 V1252153 YHCF K TRANSCRIPTIONAl REGULATOR GntR family COG1725 Cluster_586099 V1252155 I diacylglycerol kinase, catalytic COG1597 Cluster_567064 V1252156 S domain protein 12C1H Cluster_644946 V1252157 YOJI map02010 V Cyclic peptide transporter COG4615 Cluster_579660 V1252158 FADD map00071,map01100,map03320,map04146,map04920 I Long-chain-fatty-acid--CoA ligase COG1022 Cluster_629182 V1252159 HTRC S Thiamin biosynthesis protein ThiH 17QYY@proNOG Cluster_567065 V1252160 L metallophosphoesterase COG0420 Cluster_832406 V1252161 PAND map00410,map00770,map01100,map01110 H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) COG0853 Cluster_570113 V1252163 FUSA2 J Translation elongation factor COG0480 Cluster_570114 V1252164 S NA 11JFU Cluster_570116 V1252168 GRDE S reductase 0XPPI Cluster_567066 V1252169 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_748217 V1252170 RBSC-2 S ABC transporter COG1079 Cluster_687764 V1252172 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_567067 V1252173 YAAO map00310,map00330,map00960,map01100,map01110 E decarboxylase COG1982 Cluster_567068 V1252176 S permease COG2252 Cluster_567069 V1252181 MDLA map02010 V ABC transporter transmembrane region COG1132 Cluster_579661 V1252182 PGM map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase (EC 5.4.2.2 COG0033 Cluster_649032 V1252184 COABC map00770,map01100 H Phosphopantothenoylcysteine decarboxylase COG0452 Cluster_762404 V1252185 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_678776 V1252186 MSRR K TRANSCRIPTIONal COG1316 Cluster_570118 V1252187 YLME F alanine racemase domain protein COG0325 Cluster_705474 V1252188 S integral membrane protein 0XS1S Cluster_570119 V1252189 DEDA P SNARE associated Golgi COG0586 Cluster_570120 V1252190 ADDA L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation COG1074 Cluster_755109 V1252191 APT map00230,map01100 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) COG0503 Cluster_570121 V1252192 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_570122 V1252193 CSTA T carbon starvation protein COG1966 Cluster_570124 V1252196 PYC map00020,map00620,map00720,map01100,map01120,map01230 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) COG1038 Cluster_657236 V1252197 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_570125 V1252198 S Membrane COG0628 Cluster_570126 V1252199 C Inherit from COG: 4Fe-4S Ferredoxin iron-sulfur binding domain protein COG0348 Cluster_692249 V1252200 SP_0565 S Flavin reductase like domain COG1853 Cluster_570127 V1252204 ATPA map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_570128 V1252205 TNAA map00380 E tryptophanase EC 4.1.99.1 COG3033 Cluster_573321 V1252207 S NA 1249W Cluster_570129 V1252208 M Inherit from COG: YD repeat protein COG3209 Cluster_576544 V1252209 S Domain of unknown function DUF87 0ZJHN Cluster_573322 V1252210 P transporter COG0471 Cluster_570130 V1252211 U TraG family COG3505 Cluster_576545 V1252212 S Protein of unknown function (DUF1524) COG3586 Cluster_665663 V1252213 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_888189 V1252214 RPMB map03010 J 50S ribosomal protein l28 COG0227 Cluster_570132 V1252217 U, W Inherit from COG: domain protein COG5295 Cluster_570133 V1252218 RSEP map04112 M Membrane-associated zinc metalloprotease COG0750 Cluster_573323 V1252222 map01053 Q amino acid adenylation COG0318 Cluster_570134 V1252223 DGT map00230 F deoxyguanosinetriphosphate triphosphohydrolase-like protein COG0232 Cluster_592767 V1252226 map00051 M Glycosyl transferase, family 2 COG1216 Cluster_570136 V1252227 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_641068 V1252228 map02010 S Permease, YjgP YjgQ family COG0795 Cluster_573324 V1252229 map00860 E Aminotransferase class i COG0079 Cluster_711711 V1252231 GDHA map00250,map00330,map00910,map01100 E Glutamate dehydrogenase COG0334 Cluster_570137 V1252232 DNAG map03030 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 Cluster_661442 V1252234 RPLM map03010 J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) COG0102 Cluster_573325 V1252235 DNAQ2 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit epsilon COG0847 Cluster_570138 V1252237 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_669946 V1252240 YUIF S Na H antiporter COG2056 Cluster_610609 V1252241 C Nitroreductase COG0778 Cluster_669947 V1252243 L Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) COG0816 Cluster_573327 V1252244 SP_1045 I Diacylglycerol kinase COG1597 Cluster_573328 V1252245 G Alpha-1,2-mannosidase COG3537 Cluster_573329 V1252246 S NA 0YWBS Cluster_573330 V1252247 YIAO G transporter COG1638 Cluster_683328 V1252249 FABK map00061,map01100 I 2-Nitropropane dioxygenase COG2070 Cluster_599742 V1252250 S Chromosome segregation ATPase 0XP5N Cluster_570139 V1252251 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_570140 V1252252 RPSE map03010 J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) COG0098 Cluster_573332 V1252253 S Family of unknown function (DUF490) 0ZVTR Cluster_657237 V1252254 ALST map02020 E Sodium alanine symporter COG1115 Cluster_570141 V1252255 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_573333 V1252256 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_573334 V1252257 CJRC P receptor COG1629 Cluster_573335 V1252258 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_715090 V1252260 RPSR map03010 J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) COG0238 Cluster_573336 V1252261 MEGL map00260,map00270,map00450,map00920,map01100,map01110,map01230 E methionine gamma-lyase COG0626 Cluster_573337 V1252263 L Inherit from COG: transposase COG3666 Cluster_734817 V1252264 RNFB C electron transport complex, RnfABCDGE type, B subunit COG2878 Cluster_573338 V1252265 PEPN map00480,map01100 E Aminopeptidase COG0308 Cluster_573339 V1252266 N Cell surface protein 0XQ7Y Cluster_614293 V1252267 ALDA map00010,map00040,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00640,map00903,map01100,map01110,map01120 C Dehydrogenase COG1012 Cluster_573340 V1252270 AMT P ammonium transporter COG0347 Cluster_801073 V1252271 XSEB map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) 0XUAP Cluster_909160 V1252272 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_573341 V1252273 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_573342 V1252274 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_573343 V1252275 YCEG F aminodeoxychorismate lyase COG1559 Cluster_696026 V1252276 S NA 1224T Cluster_848126 V1252277 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_625499 V1252280 AHPF O Alkyl hydroperoxide reductase COG3634 Cluster_573345 V1252282 YNBB map00260,map00270,map00450,map01100,map01230 P aluminum resistance protein COG4100 Cluster_573346 V1252283 SCLAV_2282 M Peptidoglycan binding domain protein COG3409 Cluster_606961 V1252285 YDIB S ATP-binding protein COG0802 Cluster_573347 V1252286 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_573348 V1252292 S (LipO)protein 0XSFR Cluster_805261 V1252294 GLNR K transcriptional regulator COG0745 Cluster_665664 V1252297 RNFD C Electron transport complex COG4658 Cluster_573349 V1252299 MALF map02010 P binding-protein-dependent transport systems inner membrane Component 0Y7BF Cluster_789371 V1252301 S NA 11MP4 Cluster_573350 V1252302 S Protein of unknown function (DUF3078) 11J6J Cluster_573351 V1252303 PCS map00564 I Phosphatidylcholine synthase COG1183 Cluster_576546 V1252304 NTRC map02020 T two component, sigma54 specific, transcriptional regulator, Fis family COG2204 Cluster_576547 V1252305 G Sugar transporter 0XNQK Cluster_573352 V1252306 S NA 11YTD Cluster_748218 V1252308 ILVI map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E acetolactate synthase COG0028 Cluster_576548 V1252309 V Mate efflux family protein COG0534 Cluster_576549 V1252311 S acetyltransferase COG4552 Cluster_576550 V1252312 G Alpha-1,2-mannosidase COG3537 Cluster_573355 V1252313 S NA 0YQRP Cluster_744867 V1252314 MOEA H Molybdenum cofactor synthesis domain protein COG0303 Cluster_573356 V1252315 S NA 0XVB7 Cluster_573357 V1252316 U, W Pfam:Hep_Hag COG5295 Cluster_637083 V1252317 RNFD C Electron transport complex COG4658 Cluster_606962 V1252318 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_573358 V1252319 YKOE S ABC superfamily ATP binding cassette transporter membrane protein COG4721 Cluster_573359 V1252320 map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_653097 V1252321 SAGG map02010 V ABC transporter, ATP-binding protein COG1131 Cluster_576551 V1252322 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_781258 V1252323 V methylase COG0827 Cluster_576552 V1252326 ICTB M O-Antigen polymerase COG3307 Cluster_674329 V1252327 L DNA binding domain, excisionase family 0YJE8 Cluster_582906 V1252331 PEPF map04614,map05143 E Oligoendopeptidase f COG1164 Cluster_579663 V1252332 NADB map00250,map00760,map01100 H L-aspartate oxidase COG0029 Cluster_576553 V1252333 BDP_1102 V ABC transporter COG1136 Cluster_696027 V1252336 S plasmid recombination enzyme 1004W Cluster_576554 V1252338 map00860,map01100,map01110 S decarboxylase 11UPA Cluster_900764 V1252339 SLGD_00064 map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_653098 V1252340 INFA J however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) COG0361 Cluster_573363 V1252341 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_625500 V1252342 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_576559 V1252348 map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_699316 V1252349 MNME S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 Cluster_744868 V1252351 L Excinuclease ABC C subunit domain protein COG2827 Cluster_573365 V1252352 PBUG S Xanthine uracil vitamin C permease COG2252 Cluster_621702 V1252354 PTS-EIID map00051,map00520,map01100,map02060 G PTS System COG3716 Cluster_728295 V1252357 HTPX map00900 O Protease HtpX homolog COG0501 Cluster_576560 V1252358 NADE map00760,map01100 H Nad synthetase COG0388 Cluster_621703 V1252360 EF0617 S Membrane 0YGUE Cluster_621704 V1252361 SSCG_06117 S degv family COG1307 Cluster_576561 V1252362 SP_1533 S Orthopoxvirus protein of unknown function (DUF830) 0YP8N Cluster_692250 V1252363 PYRE map00240,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_579664 V1252366 K transcriptional regulator COG1414 Cluster_576562 V1252367 S NA 16RWI@proNOG Cluster_576563 V1252369 S MMPL family COG1033 Cluster_576564 V1252370 S UPF0272 protein COG1641 Cluster_576565 V1252372 S Protein of unknown function (DUF3160) 0XRJH Cluster_801074 V1252373 PRIA map03440 L Primosomal protein n' COG1198 Cluster_657238 V1252374 S tape measure 11PSY Cluster_579665 V1252375 S Membrane 0XVH9 Cluster_793145 V1252376 M YD repeat protein COG3209 Cluster_576566 V1252378 S NA 0YH2T Cluster_705475 V1252379 YNZC S UPF0291 protein COG4224 Cluster_576567 V1252380 ADE map00230,map01100 F adenine deaminase COG1001 Cluster_579667 V1252382 GMD map00051,map00520,map01100 M Gdp-mannose 4,6-dehydratase COG1089 Cluster_770085 V1252383 FEOA P Ferrous iron transport protein A COG1918 Cluster_576568 V1252385 COAX map00770,map01100 K Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) COG1521 Cluster_669948 V1252386 map00330,map01110,map01230 E Ornithine Cyclodeaminase COG2423 Cluster_576569 V1252387 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_649033 V1252388 G hydrolase family 43 0XPHB Cluster_579668 V1252389 SPOVB M Polysaccharide Biosynthesis Protein COG2244 Cluster_576570 V1252392 CAPA M Capsule synthesis protein COG2843 Cluster_576572 V1252394 U relaxase mobilization nuclease domain protein COG3843 Cluster_576573 V1252395 ERIC P Chloride channel COG0038 Cluster_696028 V1252398 PGM map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_586100 V1252399 FOLP map00790,map01100 H dihydropteroate synthase COG0294 Cluster_576574 V1252400 P TonB dependent receptor 0XNNV Cluster_579670 V1252401 T Transcription regulator 101GZ Cluster_576575 V1252402 S Membrane 0ZI5H Cluster_579671 V1252403 METH map00270,map00450,map00670,map01100,map01110,map01230 E Methionine synthase COG1410 Cluster_576576 V1252405 YWTE S hydrolase COG0561 Cluster_579672 V1252406 AHPF O Alkyl hydroperoxide reductase COG3634 Cluster_579673 V1252407 P Sodium/hydrogen exchanger family COG0475 Cluster_576577 V1252410 LMRA V ABC transporter COG1132 Cluster_576579 V1252413 RLUD J pseudouridine synthase COG0564 Cluster_579675 V1252417 RODA map00550,map04112 D cell cycle protein COG0772 Cluster_629184 V1252418 G major facilitator superfamily MFS_1 COG0477 Cluster_773765 V1252419 ISPD map00900,map01100,map01110 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COG1211 Cluster_579676 V1252420 S NA 0XPM9 Cluster_579678 V1252422 G hydrolase family 18 COG3858 Cluster_579679 V1252423 V abc transporter permease protein 0ZW5X Cluster_579680 V1252424 DEGQ map02020 O protease COG0265 Cluster_576581 V1252425 TATC map03060,map03070 U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) COG0805 Cluster_797130 V1252426 CAFA map03018 J ribonuclease COG1530 Cluster_824851 V1252427 NRDR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) COG1327 Cluster_579681 V1252429 PYC map00020,map00620,map00720,map01100,map01120,map01230 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) COG1038 Cluster_576582 V1252431 DTD J Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) COG1490 Cluster_657239 V1252433 S GH3 auxin-responsive promoter 0ZVFE Cluster_579683 V1252434 map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_579684 V1252435 S NA 11QNK Cluster_576585 V1252440 S alpha-2-macroglobulin COG2373 Cluster_851905 V1252442 YLBN S metal-binding protein COG1399 Cluster_579685 V1252443 INT S 'Phage' integrase family 0YKE0 Cluster_579686 V1252444 YRAR G, M epimerase COG0702 Cluster_696029 V1252445 map02010 V ABC transporter COG1136 Cluster_625501 V1252448 S NA 0ZKKG Cluster_579687 V1252449 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_579688 V1252450 PFLB map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_766365 V1252451 L DNA binding domain, excisionase family 11U1N Cluster_579689 V1252453 map00230 S mutt nudix family protein 11RXE Cluster_725021 V1252454 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_579691 V1252457 POLA_2 L DNA polymerase 0XRUF Cluster_579692 V1252458 FUSA2 J Translation elongation factor COG0480 Cluster_721651 V1252461 YEGQ map05120 O peptidase, U32 COG0826 Cluster_579694 V1252464 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_599744 V1252465 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_653099 V1252466 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_579696 V1252468 S S-layer homology domain 11R9R Cluster_579697 V1252469 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_579698 V1252471 GLMU E Bacterial transferase hexapeptide repeat protein COG0110 Cluster_579699 V1252472 SRTC M (sortase) family COG3764 Cluster_579700 V1252473 OPPC2 P abc transporter, permease COG1173 Cluster_683330 V1252474 CLCAR_0322 D domain protein COG5279 Cluster_579701 V1252476 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_766366 V1252477 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_641069 V1252478 YHCF K TRANSCRIPTIONAl REGULATOR GntR family COG1725 Cluster_579702 V1252479 S Membrane 11ZHS Cluster_744869 V1252480 RLMI S Methyltransferase COG1092 Cluster_582908 V1252482 S NA 0Z7KY Cluster_582909 V1252486 S SNARE-like domain protein 0XUKY Cluster_579703 V1252487 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01230 G phosphohexose isomerase COG0166 Cluster_582910 V1252488 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_579704 V1252489 ARCC map00230,map00330,map00910,map01120 E carbamate kinase COG0549 Cluster_579705 V1252490 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_781259 V1252491 PRGI map03070 U type iii secretion 17MVN@proNOG Cluster_766367 V1252493 PROC map00330,map01100,map01110,map01230 E pyrroline-5-carboxylate reductase COG0345 Cluster_582912 V1252496 YQFO S dinuclear metal center protein, YbgI family COG0327 Cluster_579706 V1252500 LIPA map00785,map01100 H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) COG0320 Cluster_751645 V1252501 RPLX map03010 J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) COG0198 Cluster_579707 V1252502 map00500,map01100 N Alpha-L-fucosidase 0XPGV Cluster_702368 V1252503 GLNQ map02010 E ABC transporter, ATP-binding protein COG1126 Cluster_696030 V1252504 BL00983 S Phage Portal Protein 11QNG Cluster_579708 V1252505 V abc transporter permease protein COG0577 Cluster_797131 V1252506 YIGF S Membrane 17PHS@proNOG Cluster_582913 V1252508 P transporter COG0733 Cluster_579709 V1252509 ATPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_582914 V1252510 MSMF map02010 P binding-protein-dependent transport systems inner membrane component COG1175 Cluster_579710 V1252513 S NA 0ZHU9 Cluster_599745 V1252515 S NA 0ZHU9 Cluster_579711 V1252516 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_582916 V1252519 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_582917 V1252521 MRDB M Rod shape-determining protein rodA COG0772 Cluster_579712 V1252524 APPB P ABC transporter (Permease COG0601 Cluster_610610 V1252527 S Protein of unknown function (DUF1149) COG4835 Cluster_582919 V1252528 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_579713 V1252529 RIBU S Membrane COG3601 Cluster_828651 V1252532 K Inherit from NOG: Transcriptional regulator 0XRI9 Cluster_582920 V1252533 KDGR K Transcriptional regulator COG1609 Cluster_582921 V1252534 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_582922 V1252535 DNAQ2 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit epsilon COG0847 Cluster_653100 V1252536 RPOD map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_582923 V1252537 S alpha beta COG0596 Cluster_884274 V1252539 MDH map00020,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120 C Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) COG0039 Cluster_683331 V1252540 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_728297 V1252541 SP_0496 P Na Pi-cotransporter COG1283 Cluster_596243 V1252542 ASP S alkaline shock protein COG1302 Cluster_582925 V1252544 GSIB map02010 E Extracellular solute-binding protein, family 5 COG0747 Cluster_582926 V1252545 P tonB-dependent receptor plug 0XSMW Cluster_579714 V1252546 AVTA map00300,map01100,map01210,map01230 K GntR family transcriptional regulator COG1167 Cluster_582927 V1252547 P acriflavin resistance protein COG0841 Cluster_582928 V1252548 PUNA map00230,map00240,map00760,map01100,map01110 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) COG1683 Cluster_582929 V1252549 APEB E M18 family aminopeptidase COG1362 Cluster_582930 V1252551 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_599746 V1252552 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_582931 V1252553 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_633038 V1252554 CCA map03013,map03018 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate COG0617 Cluster_596244 V1252555 S conjugation system ATPase, TraG family 0XSHU Cluster_641070 V1252556 TOGN map02010 P Binding-protein-dependent transport systems inner membrane component COG0395 Cluster_748222 V1252558 FHUC map02010 P Abc transporter COG1120 Cluster_781260 V1252559 D Chromosome Partitioning Protein COG1192 Cluster_582932 V1252560 S NA 0XNPT Cluster_582933 V1252561 BIOD map00780,map01100 H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) COG0132 Cluster_582934 V1252563 NADC map00760,map01100 H nicotinate-nucleotide pyrophosphorylase COG0157 Cluster_582935 V1252564 STP T Phosphatase COG0631 Cluster_582936 V1252565 MUTL2 map00660,map01100 S glutamate mutase, mutL 0XRSI Cluster_582937 V1252566 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_892308 V1252567 T protein tyrosine serine phosphatase COG2365 Cluster_751646 V1252568 WHIA K May be required for sporulation (By similarity) COG1481 Cluster_653101 V1252570 SP_1328 E sodium solute COG0591 Cluster_582938 V1252571 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_582939 V1252572 GLPF G glycerol uptake facilitator protein COG0580 Cluster_582940 V1252573 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG1754 Cluster_582941 V1252574 ALFA map00511 G alpha-L-fucosidase EC 3.2.1.51 COG3669 Cluster_777490 V1252575 N, U spore coat assembly protein SafA COG1388 Cluster_809297 V1252578 S Uncharacterized conserved protein (DUF2075) 0ZN8Y Cluster_582942 V1252583 TYRA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydrogenase COG0287 Cluster_633039 V1252585 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG1754 Cluster_582943 V1252586 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_678777 V1252587 T response regulator COG0745 Cluster_678778 V1252588 P Chromate COG2059 Cluster_715091 V1252589 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_582944 V1252590 LACX map00010,map01110,map01120 G aldose 1-epimerase COG2017 Cluster_582945 V1252592 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_582946 V1252596 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_582949 V1252600 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_687765 V1252601 map02010 E glycine betaine transport system COG1732 Cluster_586102 V1252602 E amidohydrolase COG1473 Cluster_582950 V1252604 FTCD map00340,map00670,map01100 E Glutamate formiminotransferase COG3643 Cluster_586103 V1252605 TRPP S tryptophan transport protein 11UPK Cluster_586104 V1252607 PFLX S radical SAM domain protein COG1313 Cluster_589386 V1252608 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_582951 V1252609 S transglutaminase domain-containing protein 0XNVR Cluster_731591 V1252610 S NA 0YG6V Cluster_859702 V1252611 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_586105 V1252612 S NA 11IXR Cluster_582952 V1252613 S NA 123IR Cluster_586106 V1252614 S NA 1278K Cluster_683332 V1252615 S Rhodanese-like domain 11QSF Cluster_582953 V1252616 ATPA map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_582954 V1252617 NRDF map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_758628 V1252618 RLUD J Pseudouridine synthase COG0564 Cluster_744870 V1252619 E Glycosyl Hydrolase Family 88 COG4225 Cluster_669949 V1252620 S minor capsid protein 0XSIM Cluster_586107 V1252622 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_840204 V1252624 YEAZ O Peptidase M22 Glycoprotease COG1214 Cluster_582955 V1252625 OPPA map02010 E Extracellular solute-binding protein, family 5 COG4166 Cluster_586108 V1252628 RRGB M Lpxtg-motif cell wall anchor domain protein 0XSEP Cluster_586109 V1252629 S NA 0ZX6K Cluster_582956 V1252630 SURB S G5 domain protein 0ZVV3 Cluster_731592 V1252635 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_586112 V1252637 ARGS map00970 J Arginyl-tRNA synthetase COG0018 Cluster_801075 V1252638 PFLA O Pyruvate formate-lyase COG1180 Cluster_888192 V1252639 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_751647 V1252640 METX map00270,map00920,map01100 E Homoserine O-trans-acetylase COG2021 Cluster_715092 V1252641 ARGC map00330,map01100,map01110,map01210,map01230 E N-acetylglutamate semialdehyde dehydrogenase COG0002 Cluster_805263 V1252642 S copper amine 121X1 Cluster_696031 V1252643 S SusD family 0Y5T5 Cluster_741584 V1252644 S SNARE associated Golgi COG0586 Cluster_586113 V1252645 NIRC P nitrite transporter COG2116 Cluster_728298 V1252647 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG0582 Cluster_669950 V1252650 O DnaJ domain protein COG0484 Cluster_586115 V1252652 S X-X-X-Leu-X-X-Gly heptad repeats COG1511 Cluster_586116 V1252653 PRC M Peptidase, S41 family COG0793 Cluster_586117 V1252654 ACD map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I acyl-CoA dehydrogenase COG1960 Cluster_805264 V1252656 NRDB map00230,map00240,map00480,map01100,map04115 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_586118 V1252657 P TonB-linked outer membrane protein, SusC RagA family 0ZWIF Cluster_586120 V1252659 FUCA map00051,map00053,map01100,map01120 G Aldolase COG0235 Cluster_586121 V1252660 S NA 0XTEF Cluster_629185 V1252662 S Transcription termination antitermination factor NusG 0YUUM Cluster_586122 V1252664 NOX map00190 P pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_586123 V1252665 AHPF O Alkyl hydroperoxide reductase COG3634 Cluster_586124 V1252666 map02010 G ABC transporter COG1653 Cluster_586125 V1252667 ACRB P Transporter, hydrophobe amphiphile efflux-1 (HAE1) family COG0841 Cluster_633040 V1252668 SDHA map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020,map05134 C succinate dehydrogenase, flavoprotein subunit COG1053 Cluster_661444 V1252669 SCLAV_3561 map00860,map00900,map01100,map01110 C geranylgeranyl reductase COG0644 Cluster_586126 V1252670 MALQ map00500,map01100 G 4-alpha-glucanotransferase (EC 2.4.1.25) COG1640 Cluster_586127 V1252671 YYBT T domain protein COG3887 Cluster_586128 V1252672 map05100 G s-layer domain protein 11IBF Cluster_589387 V1252673 S oligopeptide-binding protein OppA 10ER5 Cluster_589388 V1252674 SNF map00230 L Helicase COG0553 Cluster_586129 V1252675 map00270,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01230 E Aminotransferase class i COG1448 Cluster_589389 V1252676 MODB map02010 P molybdate abc transporter COG4149 Cluster_813286 V1252677 map00906,map01100,map01110 Q all-trans-retinol 13,14-reductase COG1233 Cluster_711713 V1252678 DEGT E glutamine--scyllo-inositol transaminase (EC 2.6.1.50) COG0399 Cluster_586130 V1252683 NDVA V ABC transporter, ATP-binding protein COG1132 Cluster_758629 V1252684 CITM C Citrate transporter COG2851 Cluster_586131 V1252686 ARGC map00330,map01100,map01110,map01210,map01230 E N-acetylglutamate semialdehyde dehydrogenase COG0002 Cluster_586132 V1252688 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_596245 V1252689 ACDA map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I Acyl-coA dehydrogenase COG2025 Cluster_586133 V1252691 O C-terminal, D2-small domain, of ClpB protein COG0542 Cluster_661445 V1252695 NHAC C Na H antiporter COG1757 Cluster_741585 V1252696 PROA map00330,map01100,map01230 E Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) COG0014 Cluster_586137 V1252697 S domain protein 0XS27 Cluster_738162 V1252698 LACE map00052,map01100,map02060 G IIC component COG1455 Cluster_589393 V1252699 map00450,map00970 J methionyL-tRNA synthetase COG0143 Cluster_586138 V1252700 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_589394 V1252701 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_789372 V1252702 P Chromate transport protein COG2059 Cluster_586139 V1252703 GLTA map00250,map00910,map01100,map01110,map01120,map01230 E Glutamate synthase COG0543 Cluster_748223 V1252704 MGSA map00620 G methylglyoxal synthase COG1803 Cluster_589395 V1252705 GSPL map03070 U Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) COG3297 Cluster_641071 V1252706 YKKC P multidrug resistance protein COG2076 Cluster_678779 V1252707 CYCA E amino acid COG1113 Cluster_596246 V1252708 PSTC map02010 P phosphate abc transporter COG0573 Cluster_621706 V1252709 map02010 P ABC transporter substrate-binding protein COG1840 Cluster_606963 V1252711 S NA 0ZWDS Cluster_678780 V1252712 L Primosomal protein, DnaI COG1484 Cluster_678781 V1252714 S CAAX amino terminal protease family 0ZWQM Cluster_721652 V1252715 SUFB O FeS assembly protein SUFB COG0719 Cluster_589396 V1252716 GUAB1 map00230,map00983,map01100,map01110 F Dehydrogenase COG0517 Cluster_586140 V1252717 BMUL_0472 S ABC transporter COG2984 Cluster_702369 V1252719 RPLK map03010 J This protein binds directly to 23S ribosomal RNA (By similarity) COG0080 Cluster_692252 V1252721 CAS3 L CRISPR-Associated Helicase Cas3 COG1203 Cluster_589397 V1252722 MURD map00471,map00550,map01100 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COG0771 Cluster_589399 V1252725 YHAM S UPF0597 protein COG3681 Cluster_589400 V1252726 CLPP_1 map04112 O ATP-dependent Clp protease, proteolytic subunit COG0740 Cluster_828653 V1252727 YJGR S ATP-binding protein COG0433 Cluster_596247 V1252728 PGDA G deacetylase COG0726 Cluster_589401 V1252730 L NA 0YBRV Cluster_721653 V1252731 LPXA map00540,map01100 M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) COG1043 Cluster_589402 V1252732 PIP map00330 L Prolyl aminopeptidase COG0596 Cluster_586142 V1252733 SPOVK O AAA ATPase, central domain protein COG0464 Cluster_589403 V1252734 PURL F phosphoribosylformylglycinamidine synthase COG0047 Cluster_589404 V1252737 RNFD C Electron transport complex COG4658 Cluster_599747 V1252738 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_589405 V1252740 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_589406 V1252741 S NA 0ZPG1 Cluster_589407 V1252742 S NA 0XT1C Cluster_629186 V1252745 NASD map00910,map01120 C nitrite reductase, (NAD(P)H) COG1251 Cluster_832409 V1252747 S ATPase AAA superfamily 0XSDB Cluster_687766 V1252749 CCON map00190,map01100,map02020 C cytochrome C oxidase, cbb3-type, subunit i COG3278 Cluster_589408 V1252750 S ybbr family COG4856 Cluster_589409 V1252755 S NA 0YC8I Cluster_589410 V1252757 CASA L crispr-associated protein 0XPA1 Cluster_669951 V1252758 LMRA V ABC transporter transmembrane region COG1132 Cluster_661446 V1252759 ADCC map02010 P ABC transporter COG1121 Cluster_589411 V1252760 NIFJ map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map00910,map01100,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_599748 V1252761 S NA 0YWBS Cluster_805265 V1252762 LSPL map00500,map00520,map00521,map00523,map01055,map01100,map01110 M nad-dependent epimerase dehydratase COG1088 Cluster_844220 V1252763 UGD map00040,map00053,map00500,map00520,map01100,map01110 M Udp-glucose 6-dehydrogenase COG1004 Cluster_589413 V1252765 M Inherit from COG: YD repeat protein COG3209 Cluster_589414 V1252766 L helicase COG4646 Cluster_801076 V1252767 map00051,map00500,map00520,map01100 G kinase (PfkB family COG0524 Cluster_589415 V1252768 RFAP map00540,map01100 M (lipo)polysaccharide 1741E@proNOG Cluster_589416 V1252769 map02010 E (ABC) transporter COG4608 Cluster_625502 V1252770 ISPH map00900,map01100,map01110,map03010 I Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) COG0761 Cluster_687767 V1252772 THRB map00260,map01100,map01120,map01230 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) COG0083 Cluster_589418 V1252773 S NA 12AZU Cluster_592769 V1252774 PLDB map00564 I alpha beta COG2267 Cluster_589419 V1252775 T Histidine kinase COG0745 Cluster_725022 V1252777 DGKA map00561,map00564,map01100,map04070 M Diacylglycerol kinase COG0818 Cluster_589420 V1252778 map02010 V ABC transporter, ATP-binding permease protein COG1132 Cluster_589421 V1252779 G Alpha-1,2-mannosidase COG3537 Cluster_592770 V1252780 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate (By similarity) COG0167 Cluster_589422 V1252782 CPMA S 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase COG1691 Cluster_589423 V1252783 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_637085 V1252784 YCHF J gtp-binding protein COG0012 Cluster_592771 V1252786 S NA 101UU Cluster_592772 V1252787 L helicase domain protein COG0553 Cluster_589424 V1252788 S relaxase Mobilization nuclease 0YE2V Cluster_868021 V1252790 CITF map00020,map01110,map02020 C citrate lyase, alpha COG3051 Cluster_589425 V1252791 C Dehydrogenase COG1012 Cluster_929021 V1252793 EFP J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) COG0231 Cluster_876082 V1252794 NUSB K Involved in the transcription termination process (By similarity) COG0781 Cluster_633041 V1252795 RGPF M Rhamnan synthesis protein F COG3754 Cluster_589426 V1252797 CSD1 L CRISPR-associated protein Csd1 family 0ZVNC Cluster_592774 V1252799 DCTP C symporter COG1301 Cluster_888194 V1252800 SRA map03010 J Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein 187WR@proNOG Cluster_592775 V1252801 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_653102 V1252803 map00280,map00362,map00650,map01100,map01120 I glutaconyl-CoA decarboxylase COG4799 Cluster_592776 V1252807 S NA 0XQGC Cluster_589429 V1252808 YCDO P (LipO)protein COG2822 Cluster_848127 V1252809 SPOVS S stage V sporulation protein S COG2359 Cluster_592777 V1252810 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_589430 V1252811 PRKC T serine threonine protein kinase COG0515 Cluster_836293 V1252813 map00053,map01100,map01120,map02060 G PTS System 127HI Cluster_813287 V1252814 map00053,map01100,map01120,map02060 G PTS system sugar-specific permease component COG3037 Cluster_728299 V1252815 HTRA map03010 M peptidase S1 and S6, chymotrypsin Hap COG0265 Cluster_592779 V1252817 V Resistance protein COG4767 Cluster_592781 V1252820 map00363,map00561,map00960,map01100,map01120,map04723 I Alpha Beta Hydrolase Fold protein COG2267 Cluster_592783 V1252822 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_641072 V1252823 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_592784 V1252824 PRIA map03440 L Primosomal protein n' COG1198 Cluster_592785 V1252825 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_592786 V1252826 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_592787 V1252828 S Frg domain protein 0ZXCB Cluster_589432 V1252829 FLGJ map00511 N, U flagellar rod assembly protein muramidase flgj COG1705 Cluster_592788 V1252831 METF map00670,map00720,map01100,map01120 E Methylenetetrahydrofolate reductase COG0685 Cluster_708557 V1252833 T FHA Domain-Containing protein 0ZXYF Cluster_592789 V1252834 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_762407 V1252835 ATPG map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) COG0224 Cluster_592790 V1252836 TYPA T gtp-binding protein typa COG1217 Cluster_592791 V1252838 GLPX map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120 G Fructose-1,6-bisphosphatase COG1494 Cluster_592792 V1252839 S NA 0YD3Z Cluster_592793 V1252840 DPPB map02010 P ABC transporter (Permease) COG0601 Cluster_592794 V1252841 O Peptidyl-prolyl cis-trans isomerase 0XT59 Cluster_592795 V1252842 YOJN S ATPase associated with various cellular activities aaa_5 COG0714 Cluster_755112 V1252843 G ec 3.2.1.21 COG2723 Cluster_592796 V1252845 GLYA map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01230 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) COG0112 Cluster_653103 V1252846 S Toxin-antitoxin system, toxin component 0XRRU Cluster_592797 V1252847 THIF map00730,map01100,map04122 H Thiamine biosynthesis protein ThiF COG0476 Cluster_805266 V1252849 CSM6 S CRISPR-associated protein, Csm6 11FCG Cluster_728300 V1252854 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_592798 V1252855 GCVH map00630,map01110 E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) COG0509 Cluster_592800 V1252858 CJ0268C O Band 7 family protein COG0330 Cluster_665666 V1252859 GLMU map00520,map01100,map01110 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) COG1207 Cluster_758630 V1252860 S Conserved domain protein COG4443 Cluster_592802 V1252863 RARA L recombination factor protein RarA COG2256 Cluster_592804 V1252865 map00400,map01100,map01110,map01230 E shikimate COG0703 Cluster_592805 V1252866 L transposase 1260P Cluster_758631 V1252867 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_592806 V1252868 FPR C ferredoxin-NADP reductase COG1018 Cluster_731593 V1252869 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_629187 V1252871 S NA 0XQ5H Cluster_592807 V1252872 S Inherit from NOG: membrane-spanning 4-domains, subfamily A, member 14 153T6@plaNOG Cluster_738163 V1252873 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_592808 V1252874 TELA P Resistance protein COG3853 Cluster_592809 V1252875 S transposon TraJ 0YBFN Cluster_592810 V1252877 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_603332 V1252878 GLNQ E abc transporter atp-binding protein COG1126 Cluster_606964 V1252879 map00531,map01100,map04142 P Sulfatase COG3119 Cluster_596248 V1252880 map02010 E, T PBPb COG0834 Cluster_711714 V1252881 S (LipO)protein 0XSYT Cluster_592812 V1252883 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_592813 V1252884 LEUC map00290,map00300,map00660,map01100,map01110,map01210,map01230 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) COG0065 Cluster_596250 V1252886 PANB map00770,map01100,map01110 H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) COG0413 Cluster_592815 V1252889 S NA 11JP6 Cluster_777491 V1252891 RPLW map03010 J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) COG0089 Cluster_892310 V1252892 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_817038 V1252894 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_596251 V1252897 VIRE L Virulence-associated protein e COG5545 Cluster_614295 V1252898 L DNA methylase n-4 n-6 domain protein COG0863 Cluster_592817 V1252899 S Conjugative transposon TraM protein 0XQI8 Cluster_592819 V1252903 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_592820 V1252904 E Microcompartments protein COG4577 Cluster_596252 V1252905 map00730,map01100 H IA, variant 3 COG0637 Cluster_748224 V1252906 MURE map00300,map00550 M mur ligase COG0769 Cluster_592821 V1252908 L Resolvase, N-terminal domain protein COG1961 Cluster_785358 V1252910 map00440,map01110 S -acetyltransferase 11WHN Cluster_596255 V1252911 DNAJ O DnaJ domain protein COG0484 Cluster_592822 V1252912 S NA 0XNRI Cluster_669952 V1252913 MSMX map02010 G (ABC) transporter COG3839 Cluster_603333 V1252914 S S-layer domain protein 12C8X Cluster_596256 V1252915 S Rib/alpha-like repeat 0YK85 Cluster_592823 V1252916 O DnaJ domain protein COG0484 Cluster_665667 V1252918 GLXK map00260,map00561,map00630,map01100,map01110 G Glycerate kinase COG1929 Cluster_592824 V1252920 NUCA map04210 F DNA RNA NON-specific endonuclease COG1864 Cluster_610611 V1252923 AGCS2 E amino acid carrier protein COG1115 Cluster_649036 V1252924 XPT map00230,map01100,map01110 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) COG0503 Cluster_596258 V1252927 E, P ABC transporter COG0444 Cluster_637086 V1252928 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_766368 V1252930 RPSS map03010 J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) COG0185 Cluster_592825 V1252931 S Conserved Protein COG4804 Cluster_738164 V1252933 map00230 F Adenylate cyclase COG1437 Cluster_699317 V1252934 AMID map02010 E, P ABC transporter, permease protein COG1173 Cluster_840206 V1252935 PPIB O PPIases accelerate the folding of proteins COG0652 Cluster_596259 V1252936 PLSC map00561,map00564,map01100 I Acyl-transferase COG0204 Cluster_592826 V1252937 J Glutamine amidotransferase COG2355 Cluster_592827 V1252938 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_596260 V1252939 KTRB P Potassium uptake protein COG0168 Cluster_592828 V1252941 RSMF J Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA (By similarity) COG3270 Cluster_592829 V1252942 S Secreted protein 0XRGW Cluster_744872 V1252943 S mj0936 family COG0622 Cluster_657240 V1252944 S Pfam:YadA 0ZHSU Cluster_674334 V1252945 YKAA P phosphate transport regulator COG1392 Cluster_770087 V1252946 S degv family COG1307 Cluster_625504 V1252947 S alkaline shock protein COG1302 Cluster_699318 V1252949 ADCC map02010 P ABC transporter COG1121 Cluster_596261 V1252950 M Polysaccharide biosynthesis protein COG1087 Cluster_855682 V1252951 M peptidase M23 COG0739 Cluster_596262 V1252954 S NA 11ISA Cluster_871990 V1252956 S NA 0XP3Q Cluster_820881 V1252958 HEMZ map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_633043 V1252959 MODA map02010 P ABC transporter, periplasmic molybdate-binding protein COG0725 Cluster_596263 V1252960 P Cadmium resistance transporter COG4300 Cluster_596265 V1252963 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_596266 V1252964 S NA 0YIHX Cluster_653104 V1252965 FEOB P Ferrous iron transport protein b COG0370 Cluster_637087 V1252966 YAHF map00020,map00640,map00660,map00720,map01100,map01110,map01120 C Membrane protein FdrA COG0074 Cluster_596267 V1252967 CAS3 L CRISPR-Associated Helicase Cas3 COG1203 Cluster_596270 V1252972 SP_2027 S MORN repeat protein COG4642 Cluster_596271 V1252974 METY map00270,map01100 E o-acetylhomoserine COG2873 Cluster_748225 V1252975 D Chromosome Partitioning Protein COG1192 Cluster_871991 V1252976 L Replication initiator protein A 0Y2JJ Cluster_683333 V1252977 ATPD map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG1394 Cluster_596272 V1252978 Y0877 G L-fucose isomerase COG2407 Cluster_596273 V1252980 S Arylsulfotransferase (ASST) 0XPAA Cluster_596274 V1252981 FABF map00061,map00780,map01100 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) COG0304 Cluster_596277 V1252984 PYRR map00240,map01100 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) COG2065 Cluster_596278 V1252985 HTRB map00540,map01100 M lipid A biosynthesis COG1560 Cluster_596279 V1252986 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0587 Cluster_596280 V1252987 O sufB sufD domain protein COG0719 Cluster_596281 V1252988 YBIR P transporter COG0471 Cluster_599749 V1252989 M Inherit from COG: domain protein COG4932 Cluster_596282 V1252990 S NA 0YE3I Cluster_599750 V1252991 TRSE U traE protein COG3451 Cluster_669953 V1252994 S NA 11NHY Cluster_728301 V1252995 YFBR map00230,map00240,map00760,map01100,map01110 F UPF0207 protein COG1896 Cluster_715095 V1252998 LTAE map00260,map01100,map01110,map01120,map01230 E Aldolase COG2008 Cluster_596283 V1252999 S Membrane COG2035 Cluster_599752 V1253000 NFRA M Bacteriophage N4 receptor, outer membrane subunit COG0457 Cluster_596284 V1253004 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_824857 V1253005 S NA 0YD95 Cluster_653105 V1253006 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_603334 V1253007 P tonB-dependent Receptor COG4206 Cluster_599753 V1253008 INLJ map05150 M Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps 1215X Cluster_596285 V1253010 O Periplasmic Protein COG0760 Cluster_596286 V1253011 map00500,map01100 N Alpha-L-fucosidase 0XPGV Cluster_629189 V1253012 COAA map00770,map01100 H pantothenic acid kinase COG1072 Cluster_797132 V1253013 KDGK map00030,map00040,map01100,map01120 G pfkb domain protein COG0524 Cluster_596287 V1253016 S NA 0ZVSK Cluster_596288 V1253017 PGSA map00564,map01100 I cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase COG0558 Cluster_599755 V1253018 S DNA-binding protein COG3943 Cluster_805267 V1253019 PEPI map00330 E Releases the N-terminal proline from various substrates (By similarity) COG0596 Cluster_599756 V1253021 C Nitroreductase COG0778 Cluster_596290 V1253022 RUBY C Rubrerythrin COG1592 Cluster_599757 V1253023 S NA 0ZHU9 Cluster_596291 V1253024 SPEA map00330,map01100 E Catalyzes the biosynthesis of agmatine from arginine (By similarity) COG1166 Cluster_793147 V1253025 YISR map02020 K Transcriptional regulator, ARAC family 11AZ4 Cluster_599758 V1253028 S PHP domain protein 11TE8 Cluster_599759 V1253029 YTQB map00340,map00350,map00624,map01120 Q rRNA Methylase COG0500 Cluster_599760 V1253030 Q hemolysin-type calcium-binding region COG2931 Cluster_708558 V1253032 GRXA O Glutaredoxin COG0695 Cluster_766369 V1253033 PITRM1 O peptidase COG1026 Cluster_596292 V1253034 K Transcriptional regulator, TetR family 11S7S Cluster_599762 V1253035 RPOD map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_596293 V1253036 GLKA map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G ROK family COG1940 Cluster_599763 V1253037 CCOG C cytochrome c oxidase accessory protein ccog COG0348 Cluster_599764 V1253039 GLMU map00520,map01100,map01110 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) COG1207 Cluster_766370 V1253044 PEPF E Oligoendopeptidase f COG1164 Cluster_751649 V1253045 FTSK D cell division protein FtsK COG1674 Cluster_596294 V1253047 SUCC map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120 C Succinyl-CoA synthetase subunit beta COG0045 Cluster_596295 V1253048 VBSC S Gnat family COG0456 Cluster_599767 V1253050 PAND map00410,map00770,map01100,map01110 H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) COG0853 Cluster_599768 V1253051 U TraG family COG3505 Cluster_674335 V1253053 V type III restriction enzyme 0ZVQ5 Cluster_610612 V1253055 S RNA polymerase sigma factor, sigma-70 family 11FTQ Cluster_805269 V1253056 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_599769 V1253057 YHEH V ABC transporter COG1132 Cluster_599771 V1253059 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_599772 V1253060 S mobilization protein 0XZXD Cluster_599773 V1253063 L Transposase COG3464 Cluster_657241 V1253064 FADJ map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00640,map00650,map00720,map00903,map00930,map01040,map01100,map01110,map01120 I Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities (By similarity) COG1250 Cluster_599774 V1253065 S NA 11QVU Cluster_618054 V1253067 LIVG map02010 E ABC transporter COG0411 Cluster_599775 V1253069 ILVD map00290,map00770,map01100,map01110,map01210,map01230 E Dihydroxy-acid dehydratase COG0129 Cluster_599776 V1253070 P Sodium/hydrogen exchanger family COG0475 Cluster_599780 V1253077 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_665668 V1253078 MIAB J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) COG0621 Cluster_637088 V1253079 S NA 10AWN Cluster_599782 V1253081 FDA map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01230 G fructose-bisphosphate aldolase COG3588 Cluster_599783 V1253082 COAX map00770,map01100 K Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) COG1521 Cluster_599784 V1253083 HBD map00360,map00362,map00650,map01100,map01120 I 3-hydroxybutyryl-CoA dehydrogenase (EC 1.1.1.157 COG1250 Cluster_599785 V1253084 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_599786 V1253085 RV1290C S Membrane COG4325 Cluster_599788 V1253087 TOPB L Dna topoisomerase COG0550 Cluster_599789 V1253088 map00230,map00240,map03018 J polyribonucleotide nucleotidyltransferase COG1185 Cluster_599790 V1253089 MHPE map00360,map00362,map00621,map00622,map01100,map01120 Q Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) COG0119 Cluster_599791 V1253090 YPSC L Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) COG0116 Cluster_599792 V1253091 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_606965 V1253093 YXCA I coA-substrate-specific enzyme activase COG3581 Cluster_603335 V1253096 UUP S Abc transporter COG0488 Cluster_606966 V1253097 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_618055 V1253098 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_599793 V1253100 S Protein of unknown function (DUF3160) 0XRJH Cluster_599794 V1253101 map00660,map01100 E Methylaspartate ammonia-lyase COG3799 Cluster_603336 V1253102 YDCQ D ftsk SpoIIIE family protein COG1674 Cluster_599795 V1253103 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_603337 V1253104 S NA 0XNRI Cluster_871996 V1253105 V abc transporter permease protein 0XQE2 Cluster_599796 V1253106 YDCQ D ftsk SpoIIIE family protein COG1674 Cluster_725023 V1253108 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_696032 V1253111 S NA 0YS42 Cluster_731594 V1253112 COBD map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01230 E decarboxylase COG1213 Cluster_603338 V1253114 G Alpha-1,2-mannosidase COG3537 Cluster_599797 V1253119 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_599798 V1253122 AAS map00071,map00564 I 2-acylglycerophosphoethanolamine acyltransferase COG0477 Cluster_661447 V1253123 V Endonuclease COG1403 Cluster_599799 V1253126 L PP-loop domain protein COG1606 Cluster_599800 V1253130 S basic membrane COG1744 Cluster_603341 V1253131 S Domain of unknown function (DUF1735) 11FPT Cluster_599801 V1253132 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_603342 V1253133 MVAD map00900,map01100,map01110 I diphosphomevalonate decarboxylase COG3407 Cluster_603345 V1253136 PITRM1 O peptidase COG1026 Cluster_603346 V1253137 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin 0XQTW Cluster_599802 V1253140 PEPA map00480,map01100 E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) COG0260 Cluster_748227 V1253141 NANT G Major Facilitator Superfamily 16WRR@proNOG Cluster_687768 V1253145 RV2326C map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_599803 V1253147 FEOB P Ferrous iron transport protein B COG0370 Cluster_678782 V1253149 YEAZ O Peptidase M22 Glycoprotease COG1214 Cluster_603347 V1253151 S NA 0XYW6 Cluster_603348 V1253152 PRIA map03440 L Primosomal protein n' COG1198 Cluster_603349 V1253155 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_603351 V1253157 L Recombinase COG1961 Cluster_599804 V1253158 map00030,map00230,map01100 G pfkb domain protein COG0524 Cluster_758633 V1253162 S NA 122J8 Cluster_699320 V1253163 UVRA2 map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_603353 V1253164 LDH map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120 C L-Lactate dehydrogenase COG0039 Cluster_603354 V1253165 S NA 12D73 Cluster_603356 V1253167 PPK1 map00190,map03018 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) COG0855 Cluster_603357 V1253169 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_603358 V1253170 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_603359 V1253171 S NA 11YG8 Cluster_603360 V1253172 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_603361 V1253173 map00362,map01100,map01120 S Alpha beta hydrolase COG0596 Cluster_888195 V1253174 GLGA map00500,map01100,map01110,map04973 G Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) COG0297 Cluster_661448 V1253175 FABH map00061,map01100 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) COG0332 Cluster_603362 V1253176 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_625505 V1253177 MGTA P magnesium-translocating P-type ATPase COG0474 Cluster_824860 V1253178 KDPE map02020 T Response regulator receiver domain protein COG0745 Cluster_603363 V1253180 map00680 C Na H antiporter NhaC COG1757 Cluster_674336 V1253181 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_836296 V1253182 METK S methionine adenosyltransferase 0YTXD Cluster_603364 V1253183 YJJJ S HipA domain protein 16PWK@proNOG Cluster_603365 V1253184 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_734820 V1253186 U relaxase mobilization nuclease domain protein COG3843 Cluster_603366 V1253188 RPSA map00900,map01100,map01110,map03010 J Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) COG0761 Cluster_603367 V1253189 SUFB O FeS assembly protein SUFB COG0719 Cluster_900769 V1253190 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_603368 V1253191 CSE4 L Crispr-associated protein, cse4 family 0Y6PV Cluster_917721 V1253192 S hi0933 family COG2081 Cluster_603370 V1253194 L helicase domain protein COG0553 Cluster_809301 V1253196 S Phosphopantetheine attachment site. (EC 6.1.1.13) 1228K Cluster_603372 V1253200 V abc transporter permease protein COG0577 Cluster_603374 V1253203 PYRC map00230,map00240,map00410,map00770,map00983,map01100,map01120 F dihydroorotase COG0044 Cluster_711715 V1253205 GLNA map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG3968 Cluster_603375 V1253206 CSN1 L CRISPR-associated protein, Csn1 family COG3513 Cluster_603376 V1253207 TTHE_0819 S Transposase 0ZT9V Cluster_606967 V1253208 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_603377 V1253209 YEAZ O Peptidase M22 Glycoprotease COG1214 Cluster_603378 V1253210 SODB map04146,map05016 P Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) COG0605 Cluster_603379 V1253211 RPSG map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) COG0049 Cluster_603380 V1253212 S NA 0YNFS Cluster_610614 V1253213 MUTS2 L DNA mismatch repair protein COG0249 Cluster_618056 V1253214 AMYA2 map00500,map01100,map04973 G Alpha-amylase COG0366 Cluster_606968 V1253215 L helicase COG4646 Cluster_603382 V1253221 GLGB map00500,map01100,map01110 G pullulanase, type i COG1523 Cluster_618057 V1253223 L helicase COG4646 Cluster_738166 V1253224 COBD map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01230 E decarboxylase COG0079 Cluster_603383 V1253225 S NA 11JFQ Cluster_603385 V1253227 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_773768 V1253228 ISPE map00900,map01100,map01110 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COG1947 Cluster_606970 V1253230 GLAB M Alpha-galactosidase. Removes both branched alpha-1,3- linked galactose residues of blood group B antigens and linear alpha-1,3-linked galactose structures 0ZKFF Cluster_644948 V1253232 S NA 0YDU4 Cluster_625506 V1253233 CTPC map00190 P heavy metal translocating P-type ATPase COG2217 Cluster_758634 V1253234 HEPS map00900,map01110 S heptaprenyl diphosphate synthase component I COG4769 Cluster_603386 V1253235 S NA 123S8 Cluster_725024 V1253237 MALD map02010 P ABC transporter, permease COG3833 Cluster_603387 V1253238 K parb-like COG1475 Cluster_644949 V1253241 S TRNA Guanine-N7-methyltransferase COG0220 Cluster_606972 V1253242 MUTL map03430 L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) COG0323 Cluster_606973 V1253243 V Type III COG3587 Cluster_603389 V1253244 PHOR map02020 T Histidine kinase 0XNMH Cluster_603390 V1253246 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin 0XQTW Cluster_813289 V1253248 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_855685 V1253249 S NA 0YU5P Cluster_606975 V1253251 S RimK domain protein ATP-grasp 11MC3 Cluster_606976 V1253252 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_606977 V1253253 ISDF map02010 P ABC transporter, permease COG0609 Cluster_606978 V1253254 M domain protein COG4932 Cluster_683334 V1253255 PIP1 S Phage infection protein COG1511 Cluster_789375 V1253256 RBO C Superoxide reductase COG2033 Cluster_692253 V1253257 OMPR map02020 T response regulator COG0745 Cluster_606979 V1253258 map03070 S NA 122A7 Cluster_653106 V1253259 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_653107 V1253260 TGT J Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COG0343 Cluster_603391 V1253261 YJCC T domain protein COG4943 Cluster_621707 V1253266 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_606980 V1253267 YOJN S ATPase associated with various cellular activities aaa_5 COG0714 Cluster_603392 V1253268 YCGH Q isochorismatase COG1335 Cluster_731595 V1253269 K GntR family transcriptional regulator COG1167 Cluster_606981 V1253270 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_603393 V1253271 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_603394 V1253272 ATPB map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) COG1156 Cluster_606982 V1253273 S Membrane COG0628 Cluster_606983 V1253275 FTSI map00550 M penicillin-binding protein COG0768 Cluster_820882 V1253276 FTSI map00550 M penicillin-binding protein COG0768 Cluster_610615 V1253278 DXR map00900,map01100,map01110 I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) COG0743 Cluster_606984 V1253279 ATPD map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG1394 Cluster_606985 V1253280 YIDP K GntR family transcriptional regulator COG2188 Cluster_606986 V1253281 BLAR map00312 K, T Peptidase M56 COG4219 Cluster_859706 V1253283 map00362,map00621,map00622,map01100,map01120 S 4-oxalocrotonate tautomerase COG1942 Cluster_606988 V1253284 ID587 map04974 E peptidase COG1506 Cluster_785359 V1253286 map02010 P ABC transporter COG0395 Cluster_606989 V1253287 SDAAA map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase COG1760 Cluster_738167 V1253288 S Cell surface protein 0ZXQA Cluster_606990 V1253289 V Type III restriction enzyme, res subunit 0Y2F5 Cluster_762411 V1253290 ISCU C SUF system FeS assembly protein COG0822 Cluster_606991 V1253296 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_718356 V1253299 S NA 128C9 Cluster_625507 V1253301 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_606993 V1253302 YHCH G Conserved Protein COG2731 Cluster_606994 V1253303 MURE map00300,map00550,map01100 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_625508 V1253304 S NA 12065 Cluster_606995 V1253305 GLVC map00010,map02060 G PTS System COG1264 Cluster_606996 V1253306 YLOV S dak2 domain fusion protein ylov COG1461 Cluster_606998 V1253310 GLDA map00561,map01100 C glycerol dehydrogenase COG0371 Cluster_618058 V1253311 S Protein of unknown function (DUF3071) 102GP Cluster_607001 V1253318 S NA 11ZBD Cluster_607002 V1253319 COAX map00770,map01100 K Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) COG1521 Cluster_607003 V1253320 S NA 0ZSEH Cluster_629191 V1253321 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_607004 V1253322 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_610616 V1253323 DXR map00900,map01100,map01110 I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) COG0743 Cluster_777492 V1253326 PEPF map04614,map05143 E Oligoendopeptidase f COG1164 Cluster_607005 V1253327 YADS S Membrane COG2860 Cluster_610617 V1253331 FABG map00061,map00780,map01040,map01100 S reductase 0XNW1 Cluster_607006 V1253332 K DNA-binding helix-turn-helix protein COG2946 Cluster_607007 V1253333 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_715096 V1253334 ADK map00230,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_705478 V1253335 S Domain of unknown function DUF87 0ZJHN Cluster_607008 V1253336 DCTP C symporter COG1301 Cluster_607009 V1253337 L PP-loop domain protein COG1606 Cluster_731597 V1253338 S C_GCAxxG_C_C family 11P25 Cluster_657242 V1253340 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_621708 V1253341 PURE map00230,map01100,map01110 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) COG0041 Cluster_824861 V1253343 YQHA L UPF0114 protein COG2862 Cluster_702371 V1253346 CLPB O ATPase AAA-2 domain protein COG0542 Cluster_610619 V1253348 PPDK map00620,map00710,map01100,map01120 G pyruvate phosphate dikinase COG0574 Cluster_607010 V1253349 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_809302 V1253351 MURF map00300,map00550,map01100 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) COG0770 Cluster_618059 V1253352 PQQL O Peptidase, M16 COG0612 Cluster_644950 V1253353 DPPD map02010 E, P (ABC) transporter COG0444 Cluster_721655 V1253356 AMS1 map00511 G hydrolase, family 38 COG0383 Cluster_718357 V1253357 SERP0565 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_610620 V1253358 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG2812 Cluster_762412 V1253359 J Methionyl-tRNA synthetase, beta subunit COG0073 Cluster_607012 V1253361 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin 0XQTW Cluster_610621 V1253362 S NA 0XS1W Cluster_657243 V1253364 E saf domain-containing protein COG4091 Cluster_793149 V1253365 S helix-turn-helix domain protein 122WR Cluster_705479 V1253368 RPSS map03010 J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) COG0185 Cluster_607013 V1253371 V abc transporter permease protein COG0577 Cluster_610622 V1253373 PRIA map03440 L Primosomal protein n' COG1198 Cluster_607014 V1253374 S NA 0ZBRU Cluster_696033 V1253376 M YD repeat protein COG3209 Cluster_610623 V1253377 SP_1221 V restriction 0XQ8K Cluster_687769 V1253378 COPA P Copper-exporting ATPase COG2217 Cluster_610624 V1253379 NTPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_610626 V1253382 ISPH map00900,map01100,map01110,map03010 I Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) COG0761 Cluster_610628 V1253384 L Dna topoisomerase COG0550 Cluster_633044 V1253385 YCAM E amino acid COG0531 Cluster_607015 V1253386 S peptidase, S41 11FNN Cluster_610629 V1253387 YDCP map05120 O Peptidase, U32 family COG0826 Cluster_607016 V1253388 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_758636 V1253389 PHOP map02020 T Two component transcriptional regulator (Winged helix family 11FPD Cluster_610630 V1253391 P Na Pi-cotransporter COG1283 Cluster_610631 V1253392 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_699322 V1253393 K transcriptional regulator 11GVD Cluster_637089 V1253394 PILB map03070 U pilus assembly COG2804 Cluster_610632 V1253395 POTB map02010 P ABC transporter, permease COG1176 Cluster_610633 V1253396 OPPB E, P Oligopeptide ABC transporter, permease protein AppB COG0601 Cluster_836297 V1253397 FER C Ferredoxin COG1145 Cluster_610634 V1253398 map02010 P ATP-binding protein COG1120 Cluster_610635 V1253399 P Binding-protein-dependent transport systems inner membrane component COG0601 Cluster_741588 V1253400 S inner membrane protein YbaN COG2832 Cluster_610636 V1253402 HOM map00260,map00270,map00300,map01100,map01110,map01120,map01230 E homoserine dehydrogenase COG0460 Cluster_610637 V1253403 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_661449 V1253405 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_687770 V1253407 YQJF S doxx family COG2259 Cluster_610639 V1253408 NDVA V Abc transporter COG1132 Cluster_610640 V1253409 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_610641 V1253412 S NA 0ZSQZ Cluster_785360 V1253415 RECQ map03018 L ATP-dependent DNA helicase RecQ COG0514 Cluster_610642 V1253416 POTC map02010 P putrescine abc transporter COG1177 Cluster_610643 V1253417 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_610644 V1253418 DCTP C symporter COG1301 Cluster_832410 V1253420 map00230,map01100,map01110 F AICARFT/IMPCHase bienzyme COG0138 Cluster_657244 V1253421 PRFA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) COG0216 Cluster_610645 V1253422 map00190,map00680,map01100 C ATP synthase alpha/beta chain, C terminal domain COG1155 Cluster_614298 V1253423 F Permease family COG2233 Cluster_610646 V1253425 GLGB map00500,map01100,map01110 G pullulanase, type i COG1523 Cluster_610647 V1253428 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_610648 V1253429 S NA 101UU Cluster_610649 V1253430 AMYE map02010 G solute-binding protein COG1653 Cluster_610650 V1253432 L Phage Integrase Family 0ZVXC Cluster_610651 V1253433 SCLAV_4759 L DNA helicase COG1112 Cluster_614301 V1253434 HTRA map02020,map03010 M serine protease COG0265 Cluster_610652 V1253435 YNBB map00260,map00270,map00450,map01100,map01230 P aluminum resistance protein COG4100 Cluster_614302 V1253436 YFAS S alpha-2-macroglobulin domain protein COG2373 Cluster_610653 V1253437 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_610654 V1253438 S NA 12BGB Cluster_614303 V1253440 M polysaccharide biosynthesis protein COG2244 Cluster_610655 V1253441 THRC map00260,map00750,map01100,map01120,map01230 E Threonine synthase COG0498 Cluster_797133 V1253442 RPME map03010 J 50s ribosomal protein l31 COG0254 Cluster_614305 V1253445 MURE map00300,map00550,map01100 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_809303 V1253446 RFE M Glycosyl transferase, family 4 COG0472 Cluster_614306 V1253447 PRKC T Serine threonine protein kinase COG0515 Cluster_614307 V1253448 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_614308 V1253449 HOM map00260,map00270,map00300,map01100,map01110,map01120,map01230 E homoserine dehydrogenase COG0460 Cluster_614309 V1253451 HSDM V N-6 DNA Methylase COG0286 Cluster_641074 V1253452 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_614310 V1253454 FRUA map00051,map01100,map02060 G PTS System COG1762 Cluster_610657 V1253455 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_610658 V1253456 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_614311 V1253457 YEAZ O Peptidase M22 Glycoprotease COG1214 Cluster_614312 V1253460 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_702373 V1253461 TRXB map00240,map00450 O thioredoxin reductase COG0492 Cluster_718358 V1253463 S Membrane 0ZWF2 Cluster_610660 V1253466 GATB map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 Cluster_614313 V1253468 S Phage Terminase Large Subunit COG1783 Cluster_614314 V1253469 YHAO L DNA repair exonuclease COG0420 Cluster_614316 V1253473 S ABC transporter COG3845 Cluster_618060 V1253474 APPB map02010 P Permease protein of oligopeptide ABC transporter COG0601 Cluster_610662 V1253475 NNR K Transcriptional regulator, Crp Fnr family COG0664 Cluster_610663 V1253477 map02010 E extracellular solute-binding protein 16RK7@proNOG Cluster_805270 V1253478 MT0613 S integral membrane protein COG0392 Cluster_614319 V1253481 PHOB map02020 T Two component transcriptional regulator, winged helix family COG0745 Cluster_614320 V1253482 S NA 1278K Cluster_614321 V1253484 SGAT map00053,map01100,map01120,map02060 G PTS system ascorbate-specific transporter subunit IIC COG3037 Cluster_614322 V1253486 SPOIID D SpoIID LytB domain protein COG2385 Cluster_633045 V1253489 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_653108 V1253490 RPLW map03010 J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) COG0089 Cluster_610666 V1253491 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_610667 V1253492 M RHS repeat-associated core domain protein COG3209 Cluster_614324 V1253493 CARA map00240,map00250,map01100 F carbamoyl-phosphate synthetase glutamine chain COG0505 Cluster_614325 V1253494 GRDD S fatty acid phospholipid synthesis protein plsX 0XQ1G Cluster_614326 V1253495 S plasmid recombination enzyme 0XPM6 Cluster_614327 V1253496 S CAAX amino terminal protease family protein COG1266 Cluster_801077 V1253498 YIEG S Xanthine uracil vitamin C permease COG2252 Cluster_614328 V1253499 map02010 V ABC transporter COG1132 Cluster_614329 V1253500 INSF L Integrase core domain protein COG2801 Cluster_758637 V1253501 DALK_0900 L transposase (IS4 family) protein 0XQ88 Cluster_809304 V1253503 GNTP E, G Gluconate COG2610 Cluster_657245 V1253505 E, G Membrane COG0697 Cluster_864036 V1253507 RHAD map00040,map00051 G Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) COG0235 Cluster_614331 V1253509 S phage Tail Protein 0Z1N7 Cluster_614332 V1253510 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_614333 V1253511 S NA 11F2P Cluster_728302 V1253512 ATPH map00190,map00195,map01100 C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) COG0712 Cluster_614334 V1253515 YJBB P Na Pi-cotransporter COG1283 Cluster_614336 V1253517 S Family of unknown function (DUF490) 0Z0C5 Cluster_614337 V1253519 ISPB map00900,map01110 H synthase COG0142 Cluster_614338 V1253520 E, G Citrate transporter COG2610 Cluster_744879 V1253521 RFBD map00521,map00523,map01100,map01110 M Dtdp-4-dehydrorhamnose reductase COG1898 Cluster_614340 V1253523 YFBL S peptidase, m28 COG2234 Cluster_614341 V1253524 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_683336 V1253525 S NA 0ZK8Q Cluster_614342 V1253526 P TonB dependent receptor 0XNNV Cluster_614343 V1253527 YHCX S nitrilase cyanide hydratase and apolipoprotein n-acyltransferase COG0388 Cluster_614344 V1253528 DKGB C reductase COG0656 Cluster_614345 V1253529 AGCS E amino acid carrier protein COG1115 Cluster_614346 V1253532 GLGC map00500,map00520,map01100,map01110 G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) COG0448 Cluster_614348 V1253535 L transposase COG4644 Cluster_731600 V1253536 C Binding Domain protein 0XPB7 Cluster_705482 V1253537 SGBU map00040,map00053,map01100,map01120 G L-xylulose 5-phosphate 3-epimerase COG3623 Cluster_614349 V1253538 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_614350 V1253539 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG0194 Cluster_614352 V1253541 SLT M Lytic transglycosylase catalytic COG0741 Cluster_614353 V1253542 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate (By similarity) COG0167 Cluster_614354 V1253543 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_618061 V1253545 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_618062 V1253546 TMK map00240,map01100 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) COG0125 Cluster_614356 V1253547 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_692254 V1253549 map02010 P ABC 3 transport family protein COG1108 Cluster_614358 V1253550 TRMB S Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_614359 V1253551 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_718359 V1253552 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_618063 V1253553 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_614360 V1253554 S NA 12A1I Cluster_789376 V1253555 YBIW map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_614361 V1253556 DEOD map00230,map00240,map00270,map00760,map01100,map01110 F purine nucleoside phosphorylase DeoD-type COG0813 Cluster_828658 V1253557 RPLV map03010 J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) COG0091 Cluster_614362 V1253558 WHIA K May be required for sporulation (By similarity) COG1481 Cluster_614363 V1253561 map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map05134 C fumarate reductase succinate dehydrogenase flavoprotein domain protein COG1053 Cluster_614364 V1253563 BMUL_0472 S ABC transporter COG2984 Cluster_832411 V1253564 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_692256 V1253566 S NA 0ZHU9 Cluster_618065 V1253567 S YycH protein 12BVJ Cluster_618066 V1253568 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_669955 V1253572 MALX map02010 G extracellular solute-binding protein family 1 COG2182 Cluster_618067 V1253573 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_618068 V1253575 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_848129 V1253576 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_805271 V1253577 VIRD4 map03070 U TraG TraD family protein COG3505 Cluster_614365 V1253578 VMRA V Mate efflux family protein COG0534 Cluster_820883 V1253580 S tetratricopeptide 11P8K Cluster_629193 V1253581 S von Willebrand factor, type A COG2304 Cluster_614366 V1253582 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_618069 V1253583 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_614367 V1253584 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_618070 V1253585 PITRM1 O peptidase COG1026 Cluster_614368 V1253586 BT0173 S NA 0XNSZ Cluster_618071 V1253587 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_618072 V1253589 T Histidine kinase 11MGX Cluster_618073 V1253590 CTPA M protease COG0793 Cluster_614370 V1253591 CPDA F serine threonine protein phosphatase COG1409 Cluster_785361 V1253593 LANR K Transcriptional regulator COG1476 Cluster_715097 V1253594 AMACR C L-carnitine dehydratase bile acid-inducible protein F COG1804 Cluster_618074 V1253595 S Rib/alpha-like repeat 10008 Cluster_618075 V1253596 RIMO J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) COG0621 Cluster_618076 V1253597 map05100 G s-layer domain protein 11IBF Cluster_618077 V1253600 RC1_2786 L transposase COG5433 Cluster_649038 V1253601 YPWA E carboxy-peptidase COG2317 Cluster_618078 V1253602 PYRE map00240,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_618080 V1253605 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_696034 V1253606 MT3652 map00051,map00061,map00363,map00591,map00625,map00650,map00780,map01040,map01100,map01120 I Short-chain dehydrogenase reductase Sdr COG1028 Cluster_614373 V1253609 VIRE L Virulence-associated protein e COG5545 Cluster_618081 V1253610 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_614374 V1253611 RARA L recombination factor protein RarA COG2256 Cluster_708562 V1253612 NUSA K Transcription elongation factor NusA COG0195 Cluster_618082 V1253613 S NA 0XR9X Cluster_618083 V1253614 SP_0496 P Na Pi-cotransporter COG1283 Cluster_614375 V1253617 S oxidoreductase 0XP5M Cluster_618085 V1253621 PFLB map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_618086 V1253622 V abc transporter permease protein 0ZW5X Cluster_618087 V1253623 GLUD map00250,map00330,map00430,map00471,map00910,map01100,map04964 E Glutamate dehydrogenase COG0334 Cluster_614376 V1253624 HTPX map00900 O Protease HtpX homolog COG0501 Cluster_618088 V1253626 S iron-sulfur cluster binding 100DI Cluster_614377 V1253628 APHA map00627,map00740,map01120 S class B acid phosphatase COG3700 Cluster_644951 V1253630 YAGB S Metal Dependent Phosphohydrolase COG1418 Cluster_669956 V1253632 S NA 0ZSVM Cluster_629194 V1253633 HLYX P CBS domain protein COG1253 Cluster_805272 V1253635 CPMA S 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase COG1691 Cluster_871997 V1253636 L PP-loop domain protein COG1606 Cluster_618090 V1253637 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_629195 V1253640 SECD map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) COG0342 Cluster_618091 V1253641 S UPF0597 protein COG3681 Cluster_618092 V1253642 NMB0459 S Filamentation induced by cAMP protein fic COG3177 Cluster_618093 V1253643 map02010 P ABC, transporter COG1108 Cluster_705483 V1253645 map00260,map00400,map01100,map01110,map01230 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) COG0159 Cluster_618094 V1253646 PORX T response regulator 0Y6W0 Cluster_868026 V1253647 RNMV L Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) COG1658 Cluster_817043 V1253648 TATD L Hydrolase, tatD family COG0084 Cluster_665671 V1253649 S NA 0XS1W Cluster_770089 V1253654 FBAB map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01230 G fructose-bisphosphate aldolase COG1830 Cluster_618097 V1253655 map00300,map01100,map01110,map01120,map01230 E Dihydrodipicolinate synthase COG0329 Cluster_618098 V1253656 FRUR K Transcriptional regulator, DeoR family COG1349 Cluster_751651 V1253657 S NA 124AT Cluster_618099 V1253658 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_773770 V1253659 RPSR map03010 J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) COG0238 Cluster_653109 V1253660 S acetyltransferase, (GNAT) family 11SFN Cluster_618100 V1253661 M lysozyme COG3757 Cluster_618102 V1253663 NHAA map00680 P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) COG3004 Cluster_618104 V1253665 CTPC map00190 P heavy metal translocating P-type ATPase COG2217 Cluster_633046 V1253666 APEB E M18 family aminopeptidase COG1362 Cluster_618105 V1253667 RECB map03440 L UvrD REP helicase COG1074 Cluster_618106 V1253669 S NA 0Z7FX Cluster_618107 V1253670 E ABC transporter COG0834 Cluster_618108 V1253672 GALT map00052,map00520,map01100,map01110 G UDP-glucose-hexose-1-phosphate uridylyltransferase COG4468 Cluster_618109 V1253673 I diacylglycerol kinase, catalytic COG1597 Cluster_621710 V1253674 PHOR map02020 T Histidine kinase 0XNMH Cluster_805273 V1253675 C Inherit from COG: Low-potential electron donor to a number of redox enzymes (By similarity) COG0716 Cluster_618110 V1253676 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_770090 V1253677 K Transcriptional regulator COG1396 Cluster_618111 V1253678 PROTEASE map05120 O peptidase COG0826 Cluster_621711 V1253681 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_629196 V1253683 S NA 123MT Cluster_618112 V1253685 NRNA J phosphoesterase RecJ domain protein COG0618 Cluster_621714 V1253686 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_618113 V1253688 SODC map04146,map05014,map05016,map05020 P Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) COG2032 Cluster_621715 V1253689 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_618114 V1253690 RRMJ J Hemolysin A COG1189 Cluster_692257 V1253691 map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aminotransferase COG0436 Cluster_621716 V1253692 L Dna topoisomerase COG0550 Cluster_731601 V1253694 T Two component transcriptional regulator, LuxR family COG2197 Cluster_618116 V1253696 SUPH S Hydrolase COG0561 Cluster_813291 V1253698 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_618118 V1253700 PEPI map00330 E Releases the N-terminal proline from various substrates (By similarity) COG0596 Cluster_618119 V1253704 M domain protein 11R9X Cluster_621717 V1253705 K Transcriptional Regulator AraC Family COG2207 Cluster_618120 V1253706 SRLE map00051,map02060 G Pts system, glucitol sorbitol-specific COG3732 Cluster_734823 V1253707 PHNK P phosphonate C-P lyase system protein PhnK COG4107 Cluster_618121 V1253708 BOPA E Extracellular solute-binding protein, family 5 COG0747 Cluster_859710 V1253709 S NA 12AGM Cluster_621718 V1253711 S NA 0YRVQ Cluster_618123 V1253712 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_618124 V1253716 BPET1060 L RNA-directed DNA polymerase COG3344 Cluster_621719 V1253717 MDH map00620,map00710,map01100,map01120,map02020 C malate dehydrogenase (Oxaloacetate-decarboxylating) COG0281 Cluster_884280 V1253720 S NA 0ZHU9 Cluster_789377 V1253721 G ATPase BadF BadG BcrA BcrD Type COG2971 Cluster_661450 V1253722 HCP map00910 C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) COG1151 Cluster_618126 V1253724 FTSI map00550,map01100 M Stage V sporulation protein D COG0768 Cluster_621721 V1253725 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_766371 V1253726 O Glutaredoxin COG0695 Cluster_621722 V1253728 MSBA map02010 V lipid A export permease ATP-binding protein MsbA COG1132 Cluster_618127 V1253730 S SMC domain protein COG4637 Cluster_621724 V1253732 THIF map00730,map01100,map04122 H Thiamine biosynthesis protein ThiF COG0476 Cluster_618128 V1253733 YHFE E m42 family COG1363 Cluster_621726 V1253735 PPSA map00620,map00680,map00710,map00720,map01100,map01120 G pyruvate COG0574 Cluster_618129 V1253736 S relaxase mobilization nuclease domain protein 0XNXG Cluster_621727 V1253738 T PAS domain S-box protein 0XNMH Cluster_692258 V1253739 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_625509 V1253741 CCPN K (CBS) domain COG0517 Cluster_621728 V1253743 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_725029 V1253744 map02020 T Histidine kinase COG2972 Cluster_868027 V1253747 GLNB map02020 E Nitrogen regulatory protein pii COG0347 Cluster_621729 V1253748 FBP map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120 G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 COG3855 Cluster_748230 V1253749 L Resolvase COG1961 Cluster_649039 V1253750 PFLA O Pyruvate formate-lyase COG1882 Cluster_674340 V1253752 RIMM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) 11M4J Cluster_618130 V1253753 REX K Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) COG2344 Cluster_621730 V1253754 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_871999 V1253755 YYZM S protein, conserved in bacteria COG4481 Cluster_618131 V1253756 NADE map00760,map01100 H Nad synthetase COG0388 Cluster_621732 V1253758 S atp-dependent nuclease subunit 11HAW Cluster_738168 V1253759 RPME map03010 J Binds the 23S rRNA (By similarity) COG0254 Cluster_618132 V1253761 M mechanosensitive ion channel 0XQV5 Cluster_621733 V1253762 COMB map02020,map03070,map05133 U Transport protein ComB 0XX01 Cluster_773772 V1253764 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_917724 V1253765 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_621734 V1253768 ISDE map02010 P (ABC) transporter COG0614 Cluster_621735 V1253769 S NA 0YD1F Cluster_909166 V1253770 MURD map00471,map00550,map01100 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COG0771 Cluster_801079 V1253771 FTSW map04112 D Cell division protein FtsW COG0772 Cluster_758638 V1253773 MGSA map00620 G methylglyoxal synthase COG1803 Cluster_621737 V1253774 SFUM_1163 map00620,map00640,map00643,map01100,map01120 I CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) COG4670 Cluster_621738 V1253775 OCAR_7462 map00270,map00450,map01100,map01110,map01230 E Methionine synthase COG0620 Cluster_621739 V1253777 P tonB-dependent Receptor COG4771 Cluster_621740 V1253778 YCIB M ErfK YbiS YcfS YnhG COG1376 Cluster_621741 V1253781 S integral membrane protein COG0628 Cluster_699325 V1253782 CYSK map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_621742 V1253783 S Protein of unknown function (DUF3109) 0XQ9F Cluster_621743 V1253784 map00052,map00511,map00600,map01100 G Glycosyl hydrolases family 2, TIM barrel domain COG3250 Cluster_621744 V1253786 S NA 11IB6 Cluster_777495 V1253787 LEUA map00290,map00620,map01100,map01110,map01210,map01230 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) COG0119 Cluster_621745 V1253788 CASA L crispr-associated protein 0XPA1 Cluster_728303 V1253790 LMRA V ABC transporter transmembrane region COG1132 Cluster_644952 V1253793 PHYA S Phospholipid glycerol acyltransferase COG3176 Cluster_621747 V1253794 YFDH map00051,map00510,map01100 M Glycosyl Transferase COG0463 Cluster_621748 V1253795 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_661451 V1253796 map00680 C Na H antiporter NhaC COG1757 Cluster_621749 V1253797 ERIC P Chloride channel COG0038 Cluster_621750 V1253798 IROC map02010 V abc transporter COG1132 Cluster_641075 V1253799 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_621751 V1253800 YDFG map00051,map00240,map00363,map00430,map00591,map00625,map00650,map01100,map01120 S KR domain COG4221 Cluster_784369 V1025201 GNTK map00030,map01100,map01110,map01120 G carbohydrate kinase, thermoresistant glucokinase family COG3265 Cluster_581987 V1025202 LIPA map00561,map01100 I Esterase lipase COG0657 Cluster_404980 V1025203 DACB map00550 M d-alanyl-d-alanine carboxypeptidase COG2027 Cluster_499208 V1025204 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_404981 V1025205 PRC M Peptidase, S41 family COG0793 Cluster_578776 V1025209 FRVA G PTS system, fructose-specific, IIA component COG1762 Cluster_792183 V1025210 FRVB G PTS System COG1445 Cluster_673155 V1025211 MT3945 map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase 11PV4 Cluster_704634 V1025212 PHEA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydratase COG0077 Cluster_404982 V1025213 M Polysaccharide Biosynthesis Protein COG2244 Cluster_404983 V1025214 SOJ D cobyrinic Acid a,c-diamide synthase COG1192 Cluster_572455 V1025220 S secreted protein COG2847 Cluster_404985 V1025223 map04974 E peptidase COG1506 Cluster_542271 V1025224 FPRA map00250,map00910,map01100,map01110,map01120,map01230 C reductase COG0493 Cluster_542272 V1025225 PHOU P Plays a role in the regulation of phosphate uptake COG0704 Cluster_870934 V1025226 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_406717 V1025228 G domain protein 11V8D Cluster_522534 V1025229 GREB K Transcription elongation factor GreB COG0782 Cluster_883239 V1025230 BMUL_4271 S integral membrane protein 174GP@proNOG Cluster_404986 V1025231 S NA 0ZUGA Cluster_440539 V1025232 YOBI S NA 0XPR9 Cluster_404987 V1025233 OXA map00311,map00312,map01110,map02020 V Beta-lactamase COG2602 Cluster_862986 V1025234 S NA 0ZHU9 Cluster_714255 V1025235 HSDM V type I restriction-modification system COG0286 Cluster_652021 V1025236 S Conserved Protein COG4804 Cluster_406718 V1025238 YBIT S ABC transporter COG0488 Cluster_717513 V1025240 YCFL S Lipoprotein COG5633 Cluster_581988 V1025246 map02010 E ABC transporter COG0411 Cluster_776558 V1025247 map02010 E ABC, transporter COG0410 Cluster_404988 V1025248 NQRF C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) COG2871 Cluster_710839 V1025252 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_591864 V1025255 YHCG S Conserved Protein COG4804 Cluster_656185 V1025257 PYRB map00240,map00250,map01100 F aspartate transcarbamylase COG0540 Cluster_677649 V1025258 YERC S protein, YerC YecD COG4496 Cluster_408464 V1025261 BMUL_5652 L Transposase COG2801 Cluster_406720 V1025262 PLPD M K07001 NTE family protein COG1752 Cluster_406721 V1025264 YTFL P Domain of unknown function DUF21 COG1253 Cluster_539540 V1025265 S Pfam:DUF88 COG1432 Cluster_560072 V1025266 ATTT S acetyltransferase, (GNAT) family 11VF3 Cluster_406722 V1025267 S NA 0YCFX Cluster_477462 V1025268 S relaxase mobilization nuclease domain protein 0XNXG Cluster_613281 V1025270 ACIFE_0502 map02020 P efflux system protein COG5569 Cluster_858497 V1025271 S histone family protein nucleoid-structuring protein h-ns COG2916 Cluster_743950 V1025272 S Pfam:DUF2081 COG1479 Cluster_569263 V1025273 YBJX S VirK protein COG2990 Cluster_452522 V1025274 M Inherit from COG: YD repeat protein COG3209 Cluster_408465 V1025277 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_408466 V1025279 P60 S Tetratricopeptide repeat protein 0XPJV Cluster_499210 V1025282 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_499211 V1025283 S Protein of unknown function (DUF2807) 17M8K@proNOG Cluster_533771 V1025286 ZURR K Ferric uptake regulator, Fur family COG0735 Cluster_698530 V1025288 S Protein of unknown function (DUF1488) 1833Y@proNOG Cluster_408467 V1025289 L type iii restriction protein res subunit COG1061 Cluster_761362 V1025290 S NA 11EI8 Cluster_408468 V1025291 PSTA map02010 P Phosphate ABC transporter COG0581 Cluster_410266 V1025292 M Sulfatase COG1368 Cluster_517257 V1025294 GLCD map00620,map00630,map01100,map01110,map01120 C FAD linked oxidase domain protein COG0277 Cluster_410267 V1025295 S NA 10K80 Cluster_613282 V1025297 HIGA S plasmid maintenance system antidote protein, xre family 0XURZ Cluster_410269 V1025302 G Major Facilitator 0XPHU Cluster_410270 V1025303 BL00969 S NA 0XYM3 Cluster_530997 V1025305 NMUL_A1442 L Integrase catalytic subunit 17Z4U@proNOG Cluster_695159 V1025306 FLIS map02040 N flagellar protein FliS COG1516 Cluster_750744 V1025307 FLID map02040 N flagellar hook-associated COG1345 Cluster_491606 V1025312 K Transcriptional regulator (AraC family) 11K8N Cluster_410272 V1025314 S membrane COG0730 Cluster_808241 V1025315 S Alanine rich transmembrane protein 11W3D Cluster_686571 V1025316 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_410273 V1025317 L adenine specific DNA methyltransferase COG4889 Cluster_545255 V1025319 K AraC family transcriptional regulator 176XY@proNOG Cluster_883240 V1025320 S NA 17VQM@proNOG Cluster_412077 V1025324 S NA 0ZM95 Cluster_412078 V1025327 S OmpA family 0Z6DZ Cluster_412079 V1025328 L site-specific recombinase, phage integrase family 0ZF8H Cluster_624510 V1025329 O Secreted protein COG1651 Cluster_410274 V1025332 ILVD map00290,map00770,map01100,map01110,map01210,map01230 E Dihydroxy-acid dehydratase COG0129 Cluster_442559 V1025335 BATE S Tetratricopeptide repeat protein 11FV3 Cluster_412081 V1025337 U, W Domain-Containing protein COG5295 Cluster_486790 V1025339 IORA map00633,map00680,map00720,map01120 C isoquinoline 1-oxidoreductase, alpha subunit COG2080 Cluster_519833 V1025344 PURT map00230,map00670,map01100,map01110 F Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR COG0027 Cluster_413997 V1025345 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_412082 V1025346 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_788409 V1025347 HOKA S Hok gef cell toxic protein 17PFW@proNOG Cluster_413998 V1025349 ALKK map00071,map00365,map01100,map03320,map04146,map04920 Q amp-dependent synthetase and ligase COG0318 Cluster_413999 V1025351 S NA 0ZAT5 Cluster_414000 V1025357 UGPB map02010 G extracellular solute-binding protein family 1 COG1653 Cluster_414001 V1025358 HIPO map00360 E ec 3.5.1.32 COG1473 Cluster_575682 V1025359 S relaxase mobilization nuclease domain protein 0XNXG Cluster_875071 V1025360 NARK P Nitrite extrusion protein COG2223 Cluster_539541 V1025361 NARG map00910,map01120,map02020 C nitrate reductase, alpha subunit COG5013 Cluster_733946 V1025368 YQJI K Transcriptional regulator COG1695 Cluster_609631 V1025370 DAM map03430 L Dna adenine methylase COG0338 Cluster_414003 V1025371 E amino acid COG0531 Cluster_475255 V1025373 ARSC T Arsenate reductase COG0394 Cluster_602330 V1025378 NADX map00760,map01100 H Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity) COG1712 Cluster_772743 V1025379 K LysR family Transcriptional regulator 174DX@proNOG Cluster_572456 V1025380 F Uracil permease COG2233 Cluster_415809 V1025381 FADB2 map00360,map00362,map00650,map01100,map01120 I Dehydrogenase COG1250 Cluster_414004 V1025385 P Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) COG4206 Cluster_426676 V1025387 K Transcriptional Regulator AraC Family COG3664 Cluster_624511 V1025389 FLHC map02020,map02040 K Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region 16TFE@proNOG Cluster_415810 V1025390 map05132 M repeat protein COG3209 Cluster_414005 V1025391 S NA 189VW@proNOG Cluster_525426 V1025392 COPZ map04978 P heavy metal transport detoxification protein 0XUQ1 Cluster_664544 V1025393 YHCN S UPF0379 protein yhcN 17IJU@proNOG Cluster_707788 V1025394 S NA 0ZHU9 Cluster_551270 V1025395 DPM1 map00510,map01100 M dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) 0XQRC Cluster_414006 V1025396 RBSK map00030 G ribokinase COG0524 Cluster_730749 V1025397 MJLS_1669 L transposase, IS3 IS911 family protein COG2963 Cluster_415811 V1025398 HEMB map00860,map01100,map01110 H delta-aminolevulinic acid dehydratase COG0113 Cluster_621753 V1253803 S Multi-copper polyphenol oxidoreductase laccase COG1496 Cluster_762414 V1253805 SCLAV_3941 O Band 7 protein COG0330 Cluster_621755 V1253807 S NA 0Z0UA Cluster_621756 V1253808 BASR map02020 T Two component transcriptional regulator (Winged helix family 16RRH@proNOG Cluster_621757 V1253809 M Nucleotidyl transferase COG1213 Cluster_734824 V1253813 PTSN4 map00051,map00053,map01100,map01120,map02060 G IIa component COG1762 Cluster_801080 V1253814 AMAA map00360 E amidohydrolase COG1473 Cluster_621760 V1253816 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_625510 V1253817 SPOIVFB S Peptidase M50 COG1994 Cluster_625511 V1253818 THA_2007 L Transposase COG2801 Cluster_625512 V1253822 S NA 0XYEZ Cluster_621762 V1253823 L site-specific recombinase, phage integrase family COG4974 Cluster_653110 V1253825 DXS map00730,map00900,map01100,map01110 H, I Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) COG1154 Cluster_741589 V1253827 HSLO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) COG1281 Cluster_625514 V1253828 YDFG map00051,map00240,map00363,map00430,map00591,map00625,map00650,map01100,map01120 S NADP-dependent L-serine L-allo-threonine dehydrogenase COG4221 Cluster_621763 V1253829 RLUC J Pseudouridine synthase COG0564 Cluster_621765 V1253831 XPT map00230,map01100,map01110 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) COG0503 Cluster_621766 V1253832 L Integrase 11F4A Cluster_758639 V1253833 YHGE S domain protein COG1511 Cluster_649040 V1253834 MMC1_1337 S Toxin-antitoxin system, toxin component, RelE family COG4679 Cluster_625515 V1253835 S NA 12AYQ Cluster_621767 V1253836 L Dna topoisomerase COG0550 Cluster_621768 V1253837 G Alpha-1,2-mannosidase COG3537 Cluster_678785 V1253838 GATB map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 Cluster_809305 V1253839 CASE L crispr-associated protein 0XPHC Cluster_621769 V1253842 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_621770 V1253843 map00230,map00250,map01100,map01110 F Glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_625516 V1253845 S NA 0Y037 Cluster_625517 V1253846 MDTH P Multidrug resistance protein mdtH 16TC4@proNOG Cluster_621771 V1253849 map03420,map03430 L helicase COG3973 Cluster_665672 V1253850 TOGM map02010 P binding-protein-dependent transport systems inner membrane component COG1175 Cluster_625518 V1253853 BL02049 S methyltransferase 11GJV Cluster_748231 V1253854 S NA 11EJP Cluster_625519 V1253855 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_621772 V1253856 PBP1A map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_669957 V1253858 L plasmid recombination enzyme 0ZWBR Cluster_621773 V1253859 SP_1797 G Binding-protein-dependent transport systems, inner membrane component COG0395 Cluster_711718 V1253864 map02010 V ABC transporter 0XPIZ Cluster_621774 V1253865 YCSF E lamb ycsf family protein COG1540 Cluster_770092 V1253870 HTRA map03010 M peptidase S1 and S6, chymotrypsin Hap COG0265 Cluster_625521 V1253871 SP_1548 S NA 0XPRZ Cluster_629197 V1253872 PGSA map00564,map01100 I cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase COG0558 Cluster_669958 V1253874 V Mate efflux family protein COG1151 Cluster_621776 V1253875 TOPB L Dna topoisomerase COG0550 Cluster_625522 V1253878 YQEG S had superfamily (subfamily IIIa) phosphatase COG2179 Cluster_621777 V1253882 RNHA map03030 S ribonuclease COG3341 Cluster_625523 V1253883 HEPT map00900,map01110 H synthase COG0142 Cluster_653111 V1253885 V Inherit from COG: Type II restriction enzyme, methylase COG1002 Cluster_625525 V1253888 LPCA M Glycosyl transferase family 8 COG1442 Cluster_625526 V1253889 S Protein of unknown function (DUF2961) 0XQM3 Cluster_625527 V1253890 MT0015 S division initiation protein COG3879 Cluster_625528 V1253891 S osta family 0XUST Cluster_625529 V1253892 M Outer membrane protein, OMP85 family 0XNPU Cluster_625530 V1253894 S tail tape measure protein COG5280 Cluster_621779 V1253895 S membrane 11HPM Cluster_621780 V1253896 C NADH:flavin oxidoreductase / NADH oxidase family COG1902 Cluster_789378 V1253897 V ABC transporter, ATP-binding protein COG1132 Cluster_621781 V1253898 G Ig domain protein, group 2 domain protein COG5492 Cluster_625531 V1253900 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_625532 V1253901 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_625533 V1253902 P CBS domain COG1253 Cluster_629198 V1253903 ASNA2 map00250,map00460,map00511,map00910,map01100,map01110,map04142 E asparaginase COG1446 Cluster_762415 V1253904 PPHA T serine threonine protein phosphatase COG0639 Cluster_755116 V1253905 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G Phosphohexokinase COG0205 Cluster_625534 V1253907 map02010 E Amino acid ABC transporter substrate-binding protein COG0834 Cluster_625535 V1253908 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_625536 V1253909 O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG0526 Cluster_625537 V1253910 S Transposase domain (DUF772) 10J45 Cluster_625538 V1253911 C radical SAM domain protein COG1032 Cluster_696036 V1253914 S NA 122AV Cluster_625539 V1253915 COMM O Mg chelatase subunit ChlI COG0606 Cluster_762416 V1253916 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_913389 V1253917 RSMG M Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) COG0357 Cluster_625541 V1253921 C radical SAM domain protein COG1032 Cluster_789379 V1253922 S lipolytic protein G-D-S-L family 0XSWU Cluster_625543 V1253924 S Uncharacterized protein conserved in bacteria (DUF2064) COG3222 Cluster_625544 V1253926 FUSA2 J Translation elongation factor COG0480 Cluster_625545 V1253927 TRPC map00400,map01100,map01110,map01230 E Indole-3-glycerol phosphate synthase COG0134 Cluster_741590 V1253928 S VirE N-terminal domain protein 0YIY4 Cluster_820885 V1253933 E Transglutaminase-like superfamily 0ZRG1 Cluster_741591 V1253935 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_734825 V1253936 K Transcriptional Regulator AraC Family COG2207 Cluster_625547 V1253938 LYTR2 K TRANSCRIPTIONal COG1316 Cluster_738170 V1253939 ARSB P arsenicaL-resistance protein COG0798 Cluster_625548 V1253940 DAPA map00300,map01100,map01110,map01120,map01230 E, M Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) COG0329 Cluster_801081 V1253941 S NA 0ZW6I Cluster_625549 V1253942 S ATPase AAA superfamily 0XSDB Cluster_625550 V1253943 CAD map00310,map00330,map00960,map01100,map01110 E decarboxylase COG1982 Cluster_734826 V1253944 MURG map00550,map01100,map04112 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) COG0707 Cluster_625552 V1253946 K Transcriptional regulator COG0583 Cluster_785362 V1253949 YIDD S Could be involved in insertion of integral membrane proteins into the membrane (By similarity) COG0759 Cluster_629200 V1253950 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_625553 V1253951 S pectate lyase 0XQBW Cluster_625554 V1253952 S Protein of unknown function (DUF935) COG2369 Cluster_629201 V1253953 SCRA map00500,map02060 G PTS system COG2190 Cluster_629202 V1253954 FLUTA_0256 L Transposase COG3464 Cluster_625555 V1253956 L Integrase COG0582 Cluster_625556 V1253957 METTU_1963 L Transposase 0XRAH Cluster_629203 V1253958 G hydrolase family 18 COG3858 Cluster_868029 V1253959 S Sel1 repeat COG0790 Cluster_888204 V1253965 S NA 10248 Cluster_629204 V1253966 S fad dependent oxidoreductase COG2509 Cluster_777496 V1253968 SP_1796 G extracellular solute-binding protein family 1 COG1653 Cluster_702374 V1253971 CYSE map00270,map00920,map01100,map01120,map01230 E serine acetyltransferase COG1045 Cluster_721658 V1253973 S ABC transporter COG1277 Cluster_625558 V1253974 SCRA map00500,map02060 G PTS system COG2190 Cluster_649041 V1253978 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_629205 V1253979 map00052,map01100,map02060 G PTS system, galactitol-specific IIc component COG3775 Cluster_629206 V1253980 RBR C Rubrerythrin COG1592 Cluster_876089 V1253981 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_880126 V1253983 S NA 11H5S Cluster_644953 V1253984 K Transcriptional regulator COG0583 Cluster_629208 V1253985 ETFB map00910 C Electron transfer flavoprotein COG2086 Cluster_629209 V1253986 S NA 11YHK Cluster_625559 V1253987 NADE map00760,map01100 H nh(3)-dependent nad( ) synthetase COG0171 Cluster_892316 V1253989 HISH map00340,map01100,map01110,map01230 E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) COG0118 Cluster_820888 V1253990 T Histidine kinase 0XNMH Cluster_629210 V1253992 S Membrane COG4299 Cluster_629211 V1253993 D DivIVA protein 0ZRXJ Cluster_629212 V1253994 K Transcriptional regulator, TetR family 0YTCU Cluster_629213 V1253995 MUTS2 map03430 L muts2 protein COG1193 Cluster_864040 V1253996 YHCF S response to DNA damage stimulus 17FX4@proNOG Cluster_921634 V1253997 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_797138 V1253998 RPSS map03010 J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) COG0185 Cluster_721659 V1253999 THYX map00240,map00670 F Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) COG1351 Cluster_625560 V1254000 YQJG O Glutathione S-transferase COG0435 Cluster_629214 V1254001 S Sulfotransferase domain 0ZV8C Cluster_629215 V1254002 CYCA E amino acid COG1113 Cluster_629216 V1254003 DEOC map00030 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) COG0274 Cluster_687772 V1254004 ACRB P Transporter, hydrophobe amphiphile efflux-1 (HAE1) family COG0841 Cluster_629217 V1254005 VSAL_I0172 map00362,map00363,map00626,map00650,map00903,map01100,map01110,map01120 M Polysaccharide biosynthesis protein COG1086 Cluster_629218 V1254006 S prophage antirepressor 0XPNG Cluster_851915 V1254007 MURD map00471,map00550,map01100 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COG0771 Cluster_731604 V1254008 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_625561 V1254009 TATD L Hydrolase, tatD family COG0084 Cluster_625562 V1254010 K Inherit from NOG: Transcriptional regulator, MarR Family 0XUB6 Cluster_629219 V1254011 K ParB-like COG1475 Cluster_629220 V1254013 Y0392 S TIM-barrel signal transduction protein COG5564 Cluster_629221 V1254014 L DNA (cytosine-5-)-methyltransferase COG2189 Cluster_653112 V1254015 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_629222 V1254016 S Membrane 0ZQP3 Cluster_629223 V1254017 FTSI map00550,map01100 M penicillin-binding protein COG0768 Cluster_629224 V1254018 OPUCB map02010 E ABC transporter COG1174 Cluster_855689 V1254019 CPAP_0279 L Inherit from firmNOG: Transposase COG2801 Cluster_629225 V1254021 S domain protein 12C1H Cluster_629226 V1254022 L site-specific recombinase XerD 0XS3W Cluster_649042 V1254025 S NGG1p interacting factor 3 protein, NIF3 COG3323 Cluster_629228 V1254026 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_637090 V1254027 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_629229 V1254029 GLPD map00564 C Glycerol-3-phosphate dehydrogenase COG0578 Cluster_728304 V1254030 S TraX protein 11N9P Cluster_629230 V1254032 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_644954 V1254033 NADB map00250,map00760,map01100 H L-aspartate oxidase COG0029 Cluster_644955 V1254034 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_629231 V1254035 O Erythromycin esterase COG2312 Cluster_629232 V1254036 S Filamentation induced by cAMP protein fic COG3177 Cluster_629233 V1254038 S fad dependent oxidoreductase COG2509 Cluster_629234 V1254040 KDPD map02020 T Osmosensitive K channel His kinase sensor COG2205 Cluster_629235 V1254041 G carbohydrate kinase, YjeF related protein COG0062 Cluster_629236 V1254042 RLMG J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) COG2813 Cluster_629237 V1254043 ASD map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) COG0136 Cluster_629238 V1254044 HOXA map02020 T Sigma-54 interaction domain protein COG2204 Cluster_925603 V1254045 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_758641 V1254046 SUN J ribosomal RNA small subunit methyltransferase b COG0144 Cluster_629239 V1254047 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_629240 V1254048 FIMD map05133 M outer membrane usher protein COG3188 Cluster_629241 V1254049 MSRB O reductase COG0229 Cluster_629242 V1254050 S NA 0YE9Q Cluster_629243 V1254051 UUP S Abc transporter COG0488 Cluster_629245 V1254053 MURE map00300,map00550 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_751652 V1254055 S NA 17D58@proNOG Cluster_702375 V1254059 S B3 4 domain protein COG3382 Cluster_715100 V1254062 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_629248 V1254063 S Inherit from COG: LOR SDH bifunctional protein conserved domain protein COG1915 Cluster_629249 V1254065 PDXS map00750 H Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) COG0214 Cluster_629250 V1254066 S NA 11JP6 Cluster_629251 V1254067 YBBR S ybbr family COG4856 Cluster_751653 V1254068 map00230,map01120 E Peptidase family M28 COG0624 Cluster_629252 V1254069 S Oxidoreductase domain protein COG0673 Cluster_851916 V1254071 ACCD map00061,map00253,map00620,map00640,map00720,map01100,map01110,map01120 I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) COG0777 Cluster_708564 V1254072 SRTC M (sortase) family COG3764 Cluster_629253 V1254074 S ABC transporter, ATP-binding protein COG0488 Cluster_633047 V1254075 RBSR K Transcriptional regulator COG1609 Cluster_832415 V1254076 S tonB-dependent Receptor 0Y4TD Cluster_629254 V1254077 map00860,map01100,map01110 H Uroporphyrinogen decarboxylase 11GIZ Cluster_629255 V1254078 XYLA map00040,map00051,map01100 G Xylose Isomerase COG2115 Cluster_629256 V1254079 S NA 0ZBRU Cluster_633048 V1254080 MERR1 K merr family transcriptional regulator COG0789 Cluster_633049 V1254082 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_692260 V1254083 D Chromosome Partitioning Protein COG1192 Cluster_711719 V1254084 S Divergent AAA domain protein 0XW6W Cluster_629257 V1254085 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG0469 Cluster_633050 V1254087 HSDA V restriction modification system DNA specificity COG0732 Cluster_629258 V1254089 MSCS M Mechanosensitive ion channel COG0668 Cluster_633051 V1254090 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_629259 V1254091 S Membrane COG3610 Cluster_629260 V1254092 S F420-0:Gamma-glutamyl ligase 0Y085 Cluster_629261 V1254095 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_793152 V1254096 K, L domain protein COG0553 Cluster_629262 V1254100 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_661453 V1254101 HIT F, G Histidine triad (HIT) protein COG0537 Cluster_809307 V1254102 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E amino acid aminotransferase COG0115 Cluster_629263 V1254103 UVRD map03420,map03430 L DNA helicase COG0210 Cluster_629264 V1254105 K TipAS antibiotic-recognition domain COG0789 Cluster_758642 V1254106 S NA 121AE Cluster_629265 V1254107 SUFB O FeS assembly protein SUFB COG0719 Cluster_629266 V1254108 SSCG_00091 K TRANSCRIPTIONal COG1316 Cluster_629267 V1254109 YKAA P phosphate transport regulator COG1392 Cluster_633052 V1254110 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_728305 V1254111 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_637092 V1254115 T Histidine kinase COG0642 Cluster_629269 V1254116 COBD map00860,map01100 H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) COG1270 Cluster_629270 V1254117 G transporter 0XPWC Cluster_683338 V1254119 S NA 11FTA Cluster_641077 V1254120 S Inherit from NOG: tetratricopeptide repeat protein 11FUM Cluster_633054 V1254121 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_633055 V1254122 DHAK map00561,map00680,map01100,map01120,map04622 G Dihydroxyacetone kinase COG2376 Cluster_633056 V1254123 S NA 0YDFB Cluster_633057 V1254126 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_699326 V1254127 MRDA map00550 M penicillin-binding protein COG0768 Cluster_824868 V1254130 T ATPase histidine kinase DNA gyrase B HSP90 domain protein 0XNMH Cluster_633058 V1254132 HIT map00230,map00240 F, G histidine triad (hIT) protein COG0537 Cluster_629272 V1254133 YEGW K GntR Family Transcriptional Regulator COG2188 Cluster_629273 V1254134 SP_0496 P Na Pi-cotransporter COG1283 Cluster_633059 V1254135 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_705485 V1254137 FUR K regulator Fur family 11W0B Cluster_629274 V1254139 UXAA map00040,map00053,map01100 G dehydratase COG2721 Cluster_633060 V1254140 map05100 S repeat protein 11TEE Cluster_864042 V1254141 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0847 Cluster_633061 V1254142 NANH map00520 E, M N-acetylneuraminate lyase COG0329 Cluster_629275 V1254143 NHAC map00680 C Na H antiporter COG1757 Cluster_633062 V1254144 K repB Plasmid Partition COG1475 Cluster_633063 V1254145 G Bacterial group 2 Ig-like protein COG5492 Cluster_633064 V1254147 CCMC O cytochrome C COG0755 Cluster_633066 V1254152 S NA 1249W Cluster_633067 V1254153 T Y_Y_Y domain COG3706 Cluster_734827 V1254155 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_633069 V1254156 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_633070 V1254157 MANA map00051,map00520,map01100,map01110 G mannose-6-phosphate isomerase COG1482 Cluster_633071 V1254158 M RHS repeat-associated core domain protein COG3209 Cluster_633072 V1254159 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_633073 V1254161 YICL E, G Transporter COG0697 Cluster_633074 V1254162 O Peptidase M16C associated COG1026 Cluster_725030 V1254163 CORB P CBS domain protein COG4536 Cluster_633075 V1254164 DPPD map02010 E, P (ABC) transporter COG0444 Cluster_633076 V1254165 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_773775 V1254166 MRAY map00550,map01100 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) COG0472 Cluster_744884 V1254167 RLUA J Pseudouridine synthase COG0564 Cluster_633077 V1254168 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_633078 V1254169 MEXF V AcrB AcrD family multidrug resistance protein COG0841 Cluster_661454 V1254170 HEML map00860,map01100,map01110 H Glutamate-1-semialdehyde aminotransferase COG0001 Cluster_731605 V1254171 XTH map03410 L Exodeoxyribonuclease III COG0708 Cluster_633080 V1254178 map00300,map01100,map01110,map01120,map01230 E, M Dihydrodipicolinate synthase COG0329 Cluster_705486 V1254179 RPSQ map03010 J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal COG0186 Cluster_728306 V1254180 PPX map00230 F, P ppx gppa phosphatase COG0248 Cluster_633081 V1254181 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_633082 V1254182 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_644956 V1254187 GLNP E Abc transporter COG0834 Cluster_633084 V1254188 SSCG_01435 E ABC transporter COG0765 Cluster_633085 V1254189 P Binding-protein-dependent transport systems, inner membrane component COG1175 Cluster_633086 V1254190 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_657246 V1254191 map00564,map00730 C fad dependent oxidoreductase COG0579 Cluster_633087 V1254193 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_633088 V1254194 L RtcB Protein COG1690 Cluster_633089 V1254195 THIJ S intracellular protease Pfpi family COG0693 Cluster_633090 V1254196 DUSB J Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_633091 V1254197 SERP0565 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_797139 V1254198 S Protein of unknown function (DUF3575) 0YQ2I Cluster_832417 V1254199 LGAS_0585 K phage anti-repressor protein COG3645 Cluster_824870 V1254203 RPMB map03010 J 50S ribosomal protein l28 COG0227 Cluster_633092 V1254204 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_633093 V1254205 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_633094 V1254206 map03060 U Signal peptidase I COG0681 Cluster_637094 V1254209 FPRA C domain protein COG0426 Cluster_633095 V1254211 M hydrolase, family 25 COG3757 Cluster_637095 V1254213 DCP E oligopeptidase A COG0339 Cluster_637096 V1254214 SURB S G5 domain protein 0ZVV3 Cluster_637097 V1254217 GTFA map00500 G Sucrose phosphorylase COG0366 Cluster_633096 V1254218 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_813294 V1254220 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_633097 V1254222 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0587 Cluster_641078 V1254223 E peptidase, M24 COG0006 Cluster_705487 V1254224 PSTC map02010 P phosphate abc transporter COG0573 Cluster_633098 V1254225 S NA 11MG2 Cluster_653114 V1254227 S Inherit from NOG: Ribosomal protein 1272F Cluster_637099 V1254228 EPTA S Phosphoethanolamine transferase COG2194 Cluster_781267 V1254229 SUN J ribosomal RNA small subunit methyltransferase COG0144 Cluster_633099 V1254230 S plasmid recombination enzyme 0XPM6 Cluster_633100 V1254231 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_633101 V1254234 BPEB P Transporter hydrophobe amphiphile efflux-1 (HAE1) family COG0841 Cluster_644957 V1254235 S 4'-phosphopantetheinyl transferase 0XPB1 Cluster_637100 V1254237 SSCG_03030 map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_637101 V1254238 C radical SAM domain protein COG0731 Cluster_653115 V1254239 L Integrase COG0582 Cluster_633103 V1254240 FUR P Ferric uptake COG0735 Cluster_805274 V1254241 PHOH T Phoh family COG1702 Cluster_892318 V1254242 YBEY S Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) COG0319 Cluster_633104 V1254243 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_633105 V1254244 map00360 E amidohydrolase COG1473 Cluster_805275 V1254247 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_813295 V1254255 NDK map00230,map00240,map01100,map01110 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) COG0105 Cluster_633106 V1254257 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_649044 V1254258 NIFJ map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map00910,map01100,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_633107 V1254262 S Inherit from NOG: domain protein 18D01@proNOG Cluster_633108 V1254263 YXBA S ATP-grasp COG3919 Cluster_633109 V1254264 AROF map00400,map01100,map01110,map01230 E phospho-2-dehydro-3-deoxyheptonate aldolase COG2876 Cluster_738171 V1254267 ORF35 S phage holin 17MW0@proNOG Cluster_637106 V1254268 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_637107 V1254269 S NA 0XRGD Cluster_859714 V1254271 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_702376 V1254272 map00052,map01100,map02060 G PTS System COG1762 Cluster_692262 V1254273 S NA 0Y2I2 Cluster_637108 V1254274 YAER E glyoxalase bleomycin resistance protein dioxygenase COG0346 Cluster_633110 V1254275 THIH map00730,map01100 H biosynthesis protein thiH COG1060 Cluster_637110 V1254277 S Inherit from COG: ATPase (AAA COG1373 Cluster_633111 V1254279 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_755117 V1254281 HTPG map04141,map04151,map04612,map04621,map04626,map04914,map04915,map05200,map05215 O Molecular chaperone. Has ATPase activity (By similarity) COG0326 Cluster_633112 V1254282 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_637111 V1254283 M NA 0ZYVM Cluster_809308 V1254284 SCLAV_3941 O Band 7 protein COG0330 Cluster_731607 V1254286 GGUB map02010 G ABC transporter COG4214 Cluster_633114 V1254288 G abc transporter integral membrane protein COG1172 Cluster_633115 V1254289 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_728307 V1254290 AMY map00500,map01100,map04973 G alpha-amylase COG0366 Cluster_637112 V1254291 S fusobacterium outer membrane protein family 0YCEW Cluster_637113 V1254292 S Transposase domain (DUF772) 0ZNKX Cluster_738173 V1254294 CYSQ map00920,map01100,map01120 P 3'(2'),5'-bisphosphate nucleotidase COG1218 Cluster_637116 V1254297 S Tetratricopeptide repeat protein 0ZCCT Cluster_637117 V1254298 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_637118 V1254299 S PglZ domain protein 0XQ4Q Cluster_637119 V1254300 map00280,map00362,map00650,map01100,map01120 I glutaconyl-CoA decarboxylase COG4799 Cluster_728308 V1254302 WBLA K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) 11W0R Cluster_637121 V1254304 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_872003 V1254307 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_711720 V1254308 PTH J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) COG0193 Cluster_637124 V1254310 SURE map00230,map00240,map00760,map01100,map01110 F Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) COG0496 Cluster_637125 V1254312 S NA 11F3W Cluster_637126 V1254313 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_683339 V1254314 PROP G transporter 0XP7I Cluster_637127 V1254315 RECB map03440 L UvrD REP helicase COG1074 Cluster_637128 V1254316 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_637129 V1254317 S NA 11P3R Cluster_637131 V1254319 S AAA-ATPase 0XQ4X Cluster_711721 V1254320 SERA2 map00260,map00680,map01100,map01120,map01230 E Dehydrogenase COG0111 Cluster_637132 V1254321 LICR K TRANSCRIPTIONal COG3711 Cluster_844223 V1254322 YOCR P Transporter COG0733 Cluster_637133 V1254323 S Membrane COG3619 Cluster_637134 V1254324 map02010 P Periplasmic binding protein 0XRC7 Cluster_637135 V1254325 MNAA map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_637136 V1254327 AGAR K Transcriptional regulator COG1349 Cluster_813296 V1254329 PPIB O PPIases accelerate the folding of proteins COG0652 Cluster_637138 V1254331 PPK map00190,map03018 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) COG0855 Cluster_641080 V1254332 FPRA C domain protein COG0426 Cluster_637139 V1254334 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_718361 V1254335 K AP2 domain 12D71 Cluster_637140 V1254336 S Protein of unknown function (DUF3575) 11SXP Cluster_641082 V1254337 S Membrane COG1814 Cluster_637141 V1254338 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_641083 V1254339 S NA 0YZ82 Cluster_637142 V1254340 HTH_1030 map02020 T response regulator COG2204 Cluster_641084 V1254341 S NA 11P3R Cluster_641085 V1254342 S NA 1755V@proNOG Cluster_641086 V1254343 S s-layer domain-containing protein 11ZJU Cluster_674343 V1254344 SURE map00230,map00240,map00760,map01100,map01110 F Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) COG0496 Cluster_880128 V1254346 Q Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) COG1020 Cluster_641088 V1254348 POLA_2 L DNA polymerase 0XRUF Cluster_748234 V1254349 B, K histone acetyltransferase COG1243 Cluster_711722 V1254350 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_637143 V1254351 M Glycosyl transferase family 2 0ZWA8 Cluster_637144 V1254353 ASPC map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aspartate aminotransferase COG0436 Cluster_637145 V1254357 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_637146 V1254358 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_696037 V1254359 ATPA map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) COG1155 Cluster_872004 V1254361 YOHJ S lrga family COG1380 Cluster_665674 V1254362 PGCA map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_734828 V1254364 S CRISPR-associated protein (Cas_Csn2) 11JYV Cluster_641090 V1254366 E saf domain-containing protein COG4091 Cluster_641091 V1254367 L site-specific recombinase XerD 0XS3W Cluster_637148 V1254368 S NA 0XQ20 Cluster_641092 V1254369 S NA 129EW Cluster_828660 V1254370 GLNP E ABC transporter COG0834 Cluster_864044 V1254371 GLNQ map02010 E ABC transporter, ATP-binding protein COG1126 Cluster_637149 V1254372 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_641093 V1254373 YQFL S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) COG1806 Cluster_641094 V1254374 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_641095 V1254375 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_637151 V1254378 L helicase domain protein COG0553 Cluster_657247 V1254381 SDAAA map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase COG1760 Cluster_876090 V1254382 DEF J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) COG0242 Cluster_813297 V1254383 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_641099 V1254384 O Peptidase, M16 COG0612 Cluster_641100 V1254386 S Ragb susd domain-containing protein 0Y47S Cluster_641101 V1254387 PROP G transporter 0XP7I Cluster_641102 V1254388 S fibronectin type III domain protein 0XP4A Cluster_641103 V1254389 LON map04112 O protease COG0466 Cluster_637152 V1254391 ISPA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_641104 V1254392 SBM map00280,map00630,map00640,map00720,map01100,map01120 I Methylmalonyl-coA mutase COG2185 Cluster_637153 V1254393 ENGB S Necessary for normal cell division and for the maintenance of normal septation (By similarity) COG0218 Cluster_637154 V1254394 YBBW F, H cytosine purines, uracil, thiamine, allantoin permease COG1953 Cluster_637156 V1254397 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_880129 V1254400 map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_661456 V1254402 S Pyridoxamine 5-phosphate COG5015 Cluster_637157 V1254403 M PGA_cap COG2843 Cluster_641106 V1254404 NTH map03410 L endonuclease III COG0177 Cluster_641107 V1254406 BMUL_0472 S ABC transporter COG2984 Cluster_683340 V1254407 BMUL_5920 S Rhomboid family COG0705 Cluster_641108 V1254410 map00270,map01100,map01110 E Methylenetetrahydrofolate reductase COG0685 Cluster_844224 V1254412 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_641109 V1254413 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_692263 V1254414 M mechanosensitive ion channel (MscS) COG3264 Cluster_641110 V1254415 V ABC transporter, permease COG0577 Cluster_649045 V1254417 ALKD L DNA alkylation repair enzyme COG4912 Cluster_641111 V1254418 S structural protein 11RQ6 Cluster_641113 V1254421 G domain protein 11V8D Cluster_649046 V1254422 map02010 G ABC transporter COG1653 Cluster_637160 V1254424 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_699327 V1254426 YBBP S TIGR00159 family COG1624 Cluster_641114 V1254428 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_641116 V1254430 PURC map00230,map01100,map01110 F SAICAR synthetase COG0152 Cluster_641117 V1254431 S Conserved protein COG4289 Cluster_641118 V1254433 FTSA map04112 D This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) COG0849 Cluster_641120 V1254435 GALE map00052,map00520,map01100,map01110 M udp-glucose 4-epimerase COG1087 Cluster_641121 V1254436 S NA 101UU Cluster_641122 V1254437 K, T Peptidase M56 COG4219 Cluster_683341 V1254440 S NA 121S9 Cluster_909169 V1254444 PTH J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) COG0193 Cluster_641123 V1254445 S Toxin-antitoxin system, antitoxin component 11X3H Cluster_793154 V1254446 PURM map00230,map01100,map01110 F phosphoribosylaminoimidazole synthetase COG0150 Cluster_641125 V1254448 ARGS map00970 J Arginyl-tRNA synthetase COG0018 Cluster_828661 V1254451 FLII map02040,map03070 N, U Flagellum-specific ATP synthase COG1157 Cluster_721662 V1254452 RPSA map00900,map01100,map01110,map03010 J Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) COG0761 Cluster_641126 V1254453 SEPF S Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) COG1799 Cluster_641127 V1254457 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_641128 V1254458 COML M (LipO)protein COG4105 Cluster_641130 V1254460 CCRB L Resolvase COG1961 Cluster_641132 V1254462 V T5orf172 0XQ8K Cluster_773777 V1254463 P tonB-dependent Receptor 0XP5Y Cluster_641133 V1254464 P TonB-dependent receptor 1AI9D@sphNOG Cluster_641134 V1254465 S NA 0ZNJG Cluster_758645 V1254466 PLSY map00561,map00564,map01100 S Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) COG0344 Cluster_641135 V1254467 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_644959 V1254468 P TonB-dependent receptor 0XNNV Cluster_641136 V1254469 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_793155 V1254470 S small acid-soluble spore protein, alpha beta type 122FE Cluster_813298 V1254472 CPDB map00230,map00240,map00760,map01100,map01110 F 5-nucleotidase COG0737 Cluster_644960 V1254475 ADCC map02010 P ABC transporter COG1121 Cluster_644961 V1254478 LACZ map00052,map00511,map00600,map01100 G Beta-galactosidase COG3250 Cluster_641138 V1254480 S s-layer domain-containing protein 11ZJU Cluster_644962 V1254481 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_734829 V1254483 ISPD map00900,map01100,map01110 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COG1211 Cluster_644963 V1254484 T Protein tyrosine kinase COG0515 Cluster_773778 V1254485 N, U Inherit from COG: flagellar rod assembly protein muramidase flgj COG1705 Cluster_641140 V1254486 SECF map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) COG0341 Cluster_641141 V1254490 S Arylsulfotransferase (ASST) 0XPAA Cluster_641142 V1254491 ETFB map00910 C Electron transfer flavoprotein COG2086 Cluster_649047 V1254492 RECQ map03018 L ATP-dependent DNA helicase RecQ COG0514 Cluster_641143 V1254493 ACEB map00620,map00630,map01100,map01120 C Malate synthase COG2225 Cluster_641144 V1254494 YAIT M, U outer membrane autotransporter barrel COG3468 Cluster_641147 V1254497 P Chromate COG2059 Cluster_641148 V1254498 COABC map00770,map01100 H Phosphopantothenoylcysteine decarboxylase COG0452 Cluster_641149 V1254501 SURB S G5 domain protein 0ZVV3 Cluster_641150 V1254502 S s-layer domain-containing protein 0YAE9 Cluster_725031 V1254503 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_641151 V1254504 VPA1266 map03440 L Helicase, RecD TraA family COG0507 Cluster_641152 V1254505 C Molybdopterin-binding domain of aldehyde dehydrogenase COG1529 Cluster_644965 V1254508 PKNB T Serine Threonine protein kinase COG0515 Cluster_644966 V1254510 L Reverse transcriptase COG3344 Cluster_817046 V1254511 CODA F deaminase COG0295 Cluster_644967 V1254512 U, W domain protein COG5295 Cluster_725032 V1254514 PITRM1 O peptidase COG1026 Cluster_644969 V1254515 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_644970 V1254516 map00071,map01100,map03320,map04146,map04920 I AMP-binding enzyme COG1022 Cluster_644971 V1254517 K Transcriptional regulator COG1349 Cluster_705488 V1254518 E amino acid COG0531 Cluster_644972 V1254519 map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_641153 V1254520 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_644973 V1254522 S radical SAM domain protein COG4277 Cluster_641154 V1254523 S PglZ domain protein 0XQ4Q Cluster_793156 V1254525 YBGQ map05133 M outer membrane usher protein COG3188 Cluster_932250 V1254526 YQIH O chaperone 178BZ@proNOG Cluster_644974 V1254527 map03420,map03430 L helicase COG0210 Cluster_644975 V1254528 V ABC transporter COG1132 Cluster_868033 V1254529 S NA 11TQS Cluster_888208 V1254533 S KAP P-loop COG4928 Cluster_644976 V1254534 L site-specific recombinase, phage integrase family 0ZF8H Cluster_644977 V1254535 M Capsule synthesis protein COG2843 Cluster_644978 V1254537 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_641155 V1254538 MACB map02010 V abc transporter permease protein COG0577 Cluster_734830 V1254539 YDIA S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) COG1806 Cluster_641156 V1254540 GPMA map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0588 Cluster_644979 V1254541 V N-6 DNA Methylase COG0286 Cluster_702377 V1254542 RPSG map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) COG0049 Cluster_653116 V1254544 S Inherit from COG: LOR SDH bifunctional protein conserved domain protein COG1915 Cluster_828663 V1254546 S Inherit from NOG: Methyltransferase 0XSGP Cluster_644980 V1254547 S Cdp-alcohol phosphatidyltransferase 0XQPI Cluster_708565 V1254548 FIC D cell filamentation protein COG2184 Cluster_669959 V1254550 L metallophosphoesterase COG0420 Cluster_653117 V1254551 RLUD J pseudouridine synthase COG0564 Cluster_644981 V1254552 T cyclic nucleotide-binding domain protein COG0664 Cluster_644982 V1254553 S Bacterial SH3 domain 0ZPAA Cluster_876092 V1254555 ECNB S Entericidin B 17U5S@proNOG Cluster_644984 V1254558 SECD map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) COG0342 Cluster_644986 V1254561 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_644987 V1254563 KDPA map02020 P One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) COG2060 Cluster_644988 V1254564 YJIZ G Major Facilitator superfamily 172IJ@proNOG Cluster_751654 V1254565 YBBE V Beta-lactamase COG1680 Cluster_644989 V1254566 SPEA map00330,map01100 E Catalyzes the biosynthesis of agmatine from arginine (By similarity) COG1166 Cluster_657248 V1254568 P TrkA-N domain protein COG1226 Cluster_644990 V1254569 map00360 E amidohydrolase COG1473 Cluster_805277 V1254570 MTLR K transcriptional antiterminator, bglG COG3711 Cluster_644991 V1254572 DPPA E extracellular solute-binding protein, family 5 COG0747 Cluster_644992 V1254573 PPDK map00620,map00710,map01100,map01120 G pyruvate phosphate dikinase COG0574 Cluster_644993 V1254574 LACZ map00052,map00511,map00600,map01100 G Beta-galactosidase COG3250 Cluster_644996 V1254577 VANW V VanW family COG2720 Cluster_728309 V1254579 K Bacterial regulatory proteins, tetR family 11SIP Cluster_644997 V1254580 AMYA map00500,map01100,map04973 G Alpha-amylase COG0366 Cluster_644998 V1254581 S protein, conserved in bacteria COG4805 Cluster_653118 V1254582 YQFL S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) COG1806 Cluster_665675 V1254584 M outer membrane autotransporter barrel domain protein COG3468 Cluster_644999 V1254585 GLMM map00051,map00520,map01100,map01110 G phosphomannomutase COG1109 Cluster_645000 V1254587 RC1_2786 L transposase COG5433 Cluster_649048 V1254588 AGAD map00051,map00052,map00520,map01100,map02060 G PTS system mannose/fructose/sorbose family IID component COG3716 Cluster_649049 V1254589 C Flavodoxin COG0716 Cluster_649050 V1254591 S NA 0YCVR Cluster_645001 V1254592 S NA 11KGV Cluster_645002 V1254593 GLNQ E abc transporter atp-binding protein COG1126 Cluster_669960 V1254595 NANH map00511,map00600,map04142 G BNR Asp-box repeat protein COG4409 Cluster_649051 V1254596 S domain protein 0XPXI Cluster_645003 V1254597 UXAB map00040,map01100 G Altronate oxidoreductase COG0246 Cluster_645004 V1254600 POTD map02010 E ABC transporter COG0687 Cluster_892321 V1254601 S NA 0YKBK Cluster_653119 V1254602 S NA 12BGB Cluster_649052 V1254603 COBN map00860,map01100 H cobaltochelatase, cobn subunit COG1429 Cluster_678788 V1254605 CLPB O ATPase AAA-2 domain protein COG0542 Cluster_645006 V1254607 S Caspase domain 0ZIUZ Cluster_649053 V1254609 ADE map00230,map01100 F adenine deaminase COG1001 Cluster_645007 V1254610 map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_649054 V1254612 V Ami_2 11GDG Cluster_645009 V1254615 V ABC transporter, ATP-binding protein COG1132 Cluster_645010 V1254616 O Erythromycin esterase COG2312 Cluster_766372 V1254618 M Putative cell wall binding repeat 2 COG2247 Cluster_649056 V1254619 M ion channel COG0668 Cluster_645012 V1254621 map02010 P (ABC) transporter COG0614 Cluster_645013 V1254623 KDSD M Arabinose 5-phosphate isomerase COG0794 Cluster_649057 V1254625 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_781269 V1254628 C 4Fe-4S binding domain COG0437 Cluster_649058 V1254630 RUVA map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) COG0632 Cluster_649059 V1254631 S Inherit from NOG: mannosidase 0XT8Q Cluster_718364 V1254632 HLYX P CBS domain protein COG1253 Cluster_708566 V1254633 map00362,map01100,map01120 S Alpha beta hydrolase COG0596 Cluster_645014 V1254634 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_645015 V1254636 map00521,map00523,map01055,map01100,map01110 G, M epimerase dehydratase COG0451 Cluster_649060 V1254637 map02010 P ABC transporter, permease COG1175 Cluster_645017 V1254640 UUP S Abc transporter COG0488 Cluster_645018 V1254641 FTSI map00550,map01100 M penicillin-binding protein COG0768 Cluster_649061 V1254642 SUFB O FeS assembly protein SUFB COG0719 Cluster_872007 V1254645 RPMG map03010 J 50S ribosomal protein L33 COG0267 Cluster_645019 V1254646 METE map00270,map00450,map01100,map01110,map01230 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) COG0620 Cluster_721663 V1254648 PROTEASE map05120 O peptidase, U32 COG0826 Cluster_649063 V1254649 FTSW D cell cycle protein COG0772 Cluster_645020 V1254650 NRFH map00910,map01120 C cytochrome C COG3005 Cluster_683343 V1254651 P transporter COG0733 Cluster_645021 V1254652 S ParB-like nuclease domain 0ZJMC Cluster_649064 V1254653 HTRA map03010 M peptidase S1 and S6, chymotrypsin Hap COG0265 Cluster_728310 V1254654 ASNA map00250,map00460,map00910,map01100,map01110,map01230 E asparagine synthetase A COG2502 Cluster_649065 V1254655 RPRY map02020 T response regulator COG0745 Cluster_649066 V1254656 P Na Pi-cotransporter COG1283 Cluster_649067 V1254657 YJGR S ATP-binding protein COG0433 Cluster_657249 V1254659 S Pfam:DUF1994 0XRWZ Cluster_645022 V1254660 SCRB map00052,map00500,map01100 G sucrose-6-phosphate hydrolase COG1621 Cluster_649069 V1254662 TRKA P TrkA-N domain protein COG0569 Cluster_649071 V1254664 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_748235 V1254666 map00511 S (LipO)protein 0Y1KT Cluster_773779 V1254667 PHOR map02020 T Histidine kinase 0XNMH Cluster_649072 V1254668 LEUA map00290,map00620,map01100,map01110,map01210,map01230 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) COG0119 Cluster_649073 V1254669 YBHK S UPF0052 protein COG0391 Cluster_797146 V1254670 G hydrolase family 18 COG3858 Cluster_762419 V1254671 S NA 125HN Cluster_781270 V1254672 YXBA S ATP-grasp COG3919 Cluster_649074 V1254674 GCVP map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG1003 Cluster_649075 V1254675 map02010 P Cobalt transport protein COG0619 Cluster_868035 V1254676 ARAA map00040,map01100 G Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) COG2160 Cluster_649076 V1254680 YIHS G N-acylglucosamine 2-epimerase COG2942 Cluster_649077 V1254681 SCLAV_4715 S type i phosphodiesterase nucleotide pyrophosphatase COG1524 Cluster_649078 V1254682 PCKA map00010,map00020,map00620,map00710,map01100,map01110,map01120 C Phosphoenolpyruvate Carboxylase COG1866 Cluster_649079 V1254683 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_813299 V1254684 ARGS map00970 J arginyL-tRNA synthetase COG0018 Cluster_649080 V1254686 S Cell surface protein 0XPAZ Cluster_649081 V1254687 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_649082 V1254688 PCT map00620,map00640,map00643,map01100,map01120 I CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) COG4670 Cluster_649084 V1254690 YVFR map02010 V ABC transporter COG1131 Cluster_649085 V1254691 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_649086 V1254693 E amidohydrolase COG1473 Cluster_649087 V1254694 S Phospholipase D endonuclease domain-containing protein 0Z3N0 Cluster_649088 V1254695 P Cation transporting ATPase, C-terminus COG0474 Cluster_649089 V1254696 C iron-sulfur 11G02 Cluster_649090 V1254697 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_832421 V1254698 NAGB map00520,map01100,map01110 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COG0363 Cluster_649091 V1254699 MTR map00010,map00020,map00260,map00280,map00480,map00620,map01100,map01110,map01120 C pyridine nucleotide-disulfide oxidoreductase COG1249 Cluster_649092 V1254700 BGLK G, K ROK family COG1940 Cluster_649093 V1254701 S domain protein 0Y1ZG Cluster_649094 V1254702 YAET M outer membrane protein assembly complex, YaeT protein COG4775 Cluster_649095 V1254703 V Efflux ABC transporter, permease protein 0XPE8 Cluster_649096 V1254704 PYRC map00240,map01100 F dihydroorotase COG0044 Cluster_649097 V1254705 TRMD map00900,map01100,map01110 J Specifically methylates guanosine-37 in various tRNAs (By similarity) COG0336 Cluster_649098 V1254706 S NA 11QZ9 Cluster_649099 V1254708 S Inherit from NOG: Phosphate-Selective Porin O and P 0XQB1 Cluster_649101 V1254710 RLUD J pseudouridine synthase COG0564 Cluster_809310 V1254712 CLPC O ATP-dependent Clp protease, ATP-binding subunit ClpC COG0542 Cluster_649102 V1254713 S NA 11Q1R Cluster_741592 V1254714 RPME2 map03010 J 50s ribosomal protein l31 type b COG0254 Cluster_649103 V1254715 RNHA map03030 S ribonuclease COG3341 Cluster_649104 V1254716 M polysaccharide biosynthesis protein 11RAV Cluster_649105 V1254718 OCAR_5156 E transglutaminase domain protein COG1305 Cluster_649106 V1254719 MPRF map05150 J Membrane COG2898 Cluster_649107 V1254720 PPNK map00760,map01100 G Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) COG0061 Cluster_649108 V1254722 M Inherit from NOG: domain protein 0XQTW Cluster_649109 V1254723 T transcriptional activator COG3899 Cluster_657250 V1254724 S NA 0XS1W Cluster_653120 V1254725 G hydrolase family 16 COG2273 Cluster_657251 V1254726 P Transporter COG0733 Cluster_649110 V1254727 YAFL M lipoprotein YafL COG0791 Cluster_678789 V1254729 UMUC L ImpB MucB SamB family protein COG0389 Cluster_649111 V1254730 NT5E map00230,map00240,map00630,map00760,map01100,map01110 S Hydrolase COG0546 Cluster_653121 V1254731 S NA 0YP0J Cluster_649112 V1254732 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_653123 V1254734 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_649114 V1254736 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_793158 V1254737 SPOIIE T stage ii sporulation protein e COG2208 Cluster_751656 V1254738 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_649115 V1254740 map00561,map01100 M Glycosyl transferase (Group 1 COG0438 Cluster_731609 V1254741 HOM E saf domain-containing protein COG4091 Cluster_649116 V1254742 S domain protein COG1917 Cluster_728311 V1254744 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_692264 V1254747 BCD map00071,map00280,map00281,map00650,map01100,map01110 I acyl-CoA dehydrogenase COG1960 Cluster_653124 V1254748 S F420-0:Gamma-glutamyl ligase 0Y085 Cluster_657252 V1254750 S Metal Dependent Phosphohydrolase COG2316 Cluster_773780 V1254753 S protein, conserved in bacteria 11S0N Cluster_649120 V1254754 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_653125 V1254755 UXUA map00040,map01100 G Catalyzes the dehydration of D-mannonate (By similarity) COG1312 Cluster_817047 V1254756 S toxin secretion phage lysis holin COG4824 Cluster_653126 V1254757 NHAC map00680 C Na H antiporter COG1757 Cluster_649121 V1254759 U relaxase mobilization nuclease domain protein COG3843 Cluster_649122 V1254760 ISDE map02010 P (ABC) transporter COG0614 Cluster_649123 V1254761 E Alcohol dehydrogenase GroES-like domain COG1063 Cluster_649124 V1254763 CLPB O ATP-dependent chaperone protein ClpB COG0542 Cluster_649125 V1254764 map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aminotransferase COG0436 Cluster_855694 V1254765 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G phosphohexokinase COG0205 Cluster_649126 V1254770 YXCA I coA-substrate-specific enzyme activase COG3581 Cluster_649127 V1254771 PRC M protease COG0793 Cluster_801083 V1254772 ALKA map03410 L 8-oxoguanine DNA glycosylase COG0122 Cluster_649128 V1254773 S S-layer domain protein 11R54 Cluster_766373 V1254774 PURB map00230,map00250,map01100,map01110 F Adenylosuccinate lyase COG0015 Cluster_653128 V1254775 METE map00270,map00450,map01100,map01110,map01230 E Methionine synthase COG0620 Cluster_653129 V1254777 CSTA T Carbon starvation protein CstA COG1966 Cluster_653130 V1254778 V restriction enzyme 17CDW@proNOG Cluster_653131 V1254779 S NA 0Z9TE Cluster_653133 V1254781 K Transcriptional regulator COG1167 Cluster_734832 V1254782 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_851920 V1254785 S NA 0XZN2 Cluster_687775 V1254786 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_653135 V1254787 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_649129 V1254788 PYRK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) COG0543 Cluster_715101 V1254789 EDA map00030,map00040,map00330,map00630,map01100,map01120 G aldolase COG0800 Cluster_653136 V1254790 map00550 M Penicillin-binding Protein dimerisation domain COG0772 Cluster_702378 V1254791 ARAQ map02010 G transport system, permease COG0395 Cluster_649130 V1254792 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_653137 V1254793 CLOSA_1745 L transposase COG2963 Cluster_653138 V1254794 S NA 0XTGR Cluster_649131 V1254795 SRTA M (sortase) family COG3764 Cluster_653139 V1254796 Q polyketide synthase COG3321 Cluster_649132 V1254797 PINR L Resolvase COG1961 Cluster_653141 V1254803 YIEG2 S Xanthine uracil vitamin C permease COG2252 Cluster_665677 V1254804 MTLR K TRANSCRIPTIONal COG3711 Cluster_653142 V1254806 O Peptidase, M16 COG0612 Cluster_734833 V1254807 S NA 0YWSW Cluster_653143 V1254808 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_653144 V1254809 NUOM map00190,map00910,map01100 C subunit m COG1008 Cluster_661458 V1254810 G Major Facilitator Superfamily 11MKN Cluster_653145 V1254811 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_665678 V1254812 YJJI S glycine radical enzyme YjjI family 0XNMQ Cluster_653146 V1254813 FTSI map00550,map01100 M penicillin-binding protein COG0768 Cluster_653147 V1254814 CJRC P receptor COG1629 Cluster_653149 V1254816 TILS map00230,map00983,map01100,map01110 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) COG0037 Cluster_649133 V1254818 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_653151 V1254821 CADA P Cadmium, zinc and cobalt-transporting ATPase COG2217 Cluster_653152 V1254822 S conserved protein UCP033563 COG4198 Cluster_696039 V1254823 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_721664 V1254825 YJJK S ATP-binding cassette protein, ChvD family COG0488 Cluster_653153 V1254826 V Mate efflux family protein COG0534 Cluster_653154 V1254828 YCAK map00130 S nad(p)h dehydrogenase (quinone) COG2249 Cluster_653155 V1254829 S Membrane Spanning Protein COG4720 Cluster_653156 V1254830 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_653157 V1254831 ATPA map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_653158 V1254833 map02020 V ABC transporter, permease COG0577 Cluster_653159 V1254834 DNAQ map03022,map03420 L helicase COG1199 Cluster_797147 V1254837 map02010 V ABC transporter COG1132 Cluster_653160 V1254838 DPP11 S peptidase 0XPBV Cluster_699328 V1254839 PPK2 map00190,map03018 L polyphosphate kinase 2 COG2326 Cluster_653162 V1254841 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_705489 V1254842 S NA 11XBE Cluster_653163 V1254843 PROB map00330,map01100,map01230 E Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) COG0263 Cluster_653164 V1254845 V N-6 DNA Methylase COG0286 Cluster_653165 V1254846 S NA 11YND Cluster_758646 V1254847 OPPD map02010 E, P oligopeptide ABC transporter, ATP-binding protein COG0444 Cluster_653166 V1254849 E Peptidase m29 aminopeptidase ii COG2309 Cluster_653167 V1254851 GLNA map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG0174 Cluster_653169 V1254854 YQEK map00760,map01100 H Metal Dependent Phosphohydrolase COG1713 Cluster_653170 V1254856 S NA 0ZP9J Cluster_696040 V1254857 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E brancheD-chain amino acid aminotransferase COG0115 Cluster_653171 V1254858 MURE map00300,map00550 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_692266 V1254859 LEUA map00290,map00620,map01100,map01110,map01210,map01230 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) COG0119 Cluster_653172 V1254860 RPLE map03010 J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COG0094 Cluster_888210 V1254861 RSEP map04112 M Membrane-associated zinc metalloprotease COG0750 Cluster_657253 V1254866 map00270,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01230 E Aminotransferase class i COG1448 Cluster_725033 V1254867 CADA P p-type atpase COG2217 Cluster_653176 V1254868 PGCA map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_653178 V1254870 HOM map00260,map00270,map00300,map01100,map01110,map01120,map01230 E homoserine dehydrogenase COG0460 Cluster_657254 V1254871 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_653179 V1254872 ZNUC map02010 P (ABC) transporter COG1121 Cluster_868036 V1254873 INT S 'Phage' integrase family 0YKE0 Cluster_653180 V1254876 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG3848 Cluster_848134 V1254877 TRMH map00340,map00350,map00624,map01120 J tRNA (Guanosine-2'-O-)-methyltransferase COG0566 Cluster_653181 V1254880 NFSA map00051,map00190,map00363,map00591,map00625,map00633,map00650,map01100,map01120 C nitroreductase COG0778 Cluster_653182 V1254882 SUSB map00052,map00500,map01100 G Alpha-glucosidase 0XNZD Cluster_653183 V1254883 HISD map00340,map01100,map01110,map01230 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) COG0141 Cluster_653184 V1254884 YIEG S Xanthine uracil vitamin C permease COG2252 Cluster_657255 V1254885 PRFC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) COG4108 Cluster_653185 V1254887 map02010 V ABC transporter 0XPIZ Cluster_653186 V1254888 NUOH map00190,map00910,map01100 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) COG1005 Cluster_653187 V1254889 L Replication initiator protein A 0Y2JJ Cluster_657256 V1254890 XYLG S ABC transporter COG3845 Cluster_653188 V1254891 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_657257 V1254892 LRGB map02020 M lrgb family COG1346 Cluster_657258 V1254894 DEAD map03018 L ATP-dependent RNA helicase COG0513 Cluster_653190 V1254895 M YD repeat protein COG3209 Cluster_781273 V1254896 I Phosphoesterase, PA-phosphatase related COG0671 Cluster_653191 V1254897 D ATP-binding protein COG0489 Cluster_657259 V1254900 GLGC map00500,map00520,map01100,map01110 G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) COG0448 Cluster_657260 V1254903 ASPA map00250,map00910,map01100 E Aspartate ammonia-lyase COG1027 Cluster_657261 V1254904 S NA 0YNFS Cluster_657262 V1254905 S NA 11UGW Cluster_657263 V1254907 YABB map00340,map00350,map00624,map01120 L Methyltransferase COG4123 Cluster_705490 V1254908 S NA 0ZTS3 Cluster_678790 V1254909 MDTP M RND efflux system, outer membrane lipoprotein COG1538 Cluster_653192 V1254910 SP_1282 S abc transporter atp-binding protein COG0488 Cluster_657264 V1254911 S NA 0YY2Z Cluster_657265 V1254914 MEGL map00260,map00270,map00450,map00920,map01100,map01110,map01230 E methionine gamma-lyase COG0626 Cluster_657266 V1254915 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_657267 V1254916 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_785365 V1254917 MT0613 S integral membrane protein COG0392 Cluster_657268 V1254918 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_657269 V1254919 YPUA S secreted protein COG4086 Cluster_657270 V1254920 MTRB map02020 T Histidine kinase 0XNMH Cluster_653193 V1254921 LEPB map03060 U Signal peptidase i COG0681 Cluster_657271 V1254922 map00860,map01100 H cobaltochelatase, cobn subunit COG1429 Cluster_653194 V1254924 YHBJ S Displays ATPase and GTPase activities (By similarity) COG1660 Cluster_657272 V1254927 METQ map02010 P (LipO)protein COG1464 Cluster_674344 V1254928 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G phosphohexokinase COG0205 Cluster_657273 V1254929 L Transposase COG3436 Cluster_836301 V1254931 MANY map00051,map00520,map01100,map02060 G PTS System COG3715 Cluster_657274 V1254932 S NA 1205I Cluster_696041 V1254933 METY map00270,map01100 E DegT/DnrJ/EryC1/StrS aminotransferase family COG2873 Cluster_657275 V1254936 S NA 11RES Cluster_657276 V1254937 S NA 0YD8Y Cluster_748237 V1254938 YAEF S (LipO)protein 17AMC@proNOG Cluster_657277 V1254939 FABI map00061,map00780,map01100 I Enoyl- acyl-carrier-protein reductase NADH COG0623 Cluster_657278 V1254940 NRDB map00230,map00240,map00480,map01100,map04115 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_653197 V1254941 SPEA map00310,map00330,map00480,map00960,map01100,map01110,map01230,map05146 E decarboxylase COG1982 Cluster_657279 V1254942 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_669961 V1254943 M Cell Wall COG2866 Cluster_653198 V1254944 M hydrolase, family 25 COG3757 Cluster_657280 V1254949 CJRC P receptor COG1629 Cluster_653200 V1254950 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_770097 V1254951 QUEG C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) COG1600 Cluster_657281 V1254954 XPT map00230,map01100,map01110 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) COG0503 Cluster_657283 V1254956 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_657285 V1254958 S NA COG4926 Cluster_657286 V1254959 G Glycosyltransferase 36 COG3459 Cluster_705491 V1254962 SMC00019 K UPF0301 protein COG1678 Cluster_687776 V1254964 PITA P phosphate transporter COG0306 Cluster_785366 V1254966 OMPH M outer membrane chaperone Skp (OmpH) 11GII Cluster_657290 V1254967 M Cell wall binding repeat 2-containing protein COG2247 Cluster_848136 V1254968 NAGA map00052,map00520,map01110 G GlcNAc 6-P deacetylase COG1820 Cluster_665679 V1254969 PLPD S Phospholipase, patatin family COG1752 Cluster_731610 V1254970 SBP map02010 P Sulfate ABC transporter periplasmic sulfate-binding protein COG1613 Cluster_661459 V1254971 MNME S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 Cluster_657291 V1254972 PMT M glycosyl transferase, family 39 COG1928 Cluster_702379 V1254975 THYA map00240,map00670,map01100 F Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) COG0207 Cluster_657293 V1254976 L DNA helicase COG1112 Cluster_657294 V1254978 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01230 G phosphohexose isomerase COG0166 Cluster_657296 V1254983 METQ map02010 P (Lipo)protein COG1464 Cluster_657297 V1254984 PURQ map00230,map01100,map01110 F Phosphoribosylformylglycinamidine synthase I COG0047 Cluster_657298 V1254985 NRDR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) COG1327 Cluster_657299 V1254986 S NA 12D1P Cluster_832423 V1254987 GLGB map00500,map01100,map01110 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) COG0296 Cluster_809312 V1254988 O Peptidyl-prolyl cis-trans isomerase COG0760 Cluster_657300 V1254989 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_657301 V1254991 NAMU_0682 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_657302 V1254993 BA_0233 E, P ABC transporter, permease protein COG1173 Cluster_657303 V1254994 CELB map02060 G PTS system, cellobiose-specific IIC component COG1455 Cluster_657304 V1254996 VPA1266 map03440 L Helicase, RecD TraA family COG4932 Cluster_661460 V1254998 BAS0367 map02010 P Binding-protein-dependent transport systems, inner membrane component COG0600 Cluster_657305 V1255002 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_657306 V1255003 YCGV M, U Autotransporter COG3468 Cluster_657307 V1255004 HEML map00860,map01100,map01110 H Glutamate-1-semialdehyde aminotransferase COG0001 Cluster_657308 V1255005 PACL P calcium-transporting ATPase COG0474 Cluster_721665 V1255006 map02010 S NA 122U9 Cluster_755119 V1255007 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_657309 V1255008 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_721666 V1255009 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_657310 V1255011 GGT map00430,map00460,map00480,map00590,map01100 E K00681 gamma-glutamyltranspeptidase EC 2.3.2.2 COG0405 Cluster_657311 V1255012 ALD map00250,map00430,map01100 E alanine dehydrogenase COG0686 Cluster_762424 V1255013 S NA 11YCW Cluster_661462 V1255014 FCHA map00670,map01100 E Methenyltetrahydrofolate cyclohydrolase COG3404 Cluster_657312 V1255016 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_661464 V1255017 B, K histone acetyltransferase COG1243 Cluster_744887 V1255018 SCLAV_3539 G phosphoglycerate mutase COG0406 Cluster_751657 V1255020 GLGD map00500,map00520,map01100,map01110 M glucose-1-phosphate adenylyltransferase, glgd subunit COG0448 Cluster_661465 V1255026 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_657314 V1255027 P CBS domain protein COG1253 Cluster_661466 V1255028 S NA 1259Q Cluster_661467 V1255030 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_657315 V1255032 ILVC map00290,map00770,map01100,map01110,map01210,map01230 E Alpha-keto-beta-hydroxylacyl reductoisomerase COG0059 Cluster_738174 V1255033 S NA 0ZPG1 Cluster_661469 V1255034 TGT J Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COG0343 Cluster_657316 V1255036 map02010 P ABC transporter COG1122 Cluster_661470 V1255041 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_657317 V1255042 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_661471 V1255043 YADE G polysaccharide deacetylase COG0726 Cluster_661472 V1255044 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_661473 V1255045 HYPB K, O Hydrogenase accessory protein HypB COG0378 Cluster_657318 V1255046 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii subunits gamma and tau COG2812 Cluster_785367 V1255047 AVTA map00300,map01100,map01210,map01230 K GntR family transcriptional regulator COG1167 Cluster_661474 V1255048 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_711723 V1255049 YKUD M ErfK ybiS ycfS ynhG family protein COG1376 Cluster_661475 V1255050 HYDE map00780,map01100 H radical SAM domain protein COG0502 Cluster_661476 V1255052 L helicase COG1204 Cluster_661477 V1255053 MMDA map00280,map00630,map00640,map00720,map01100,map01120 I carboxylase COG4799 Cluster_864050 V1255054 map02010 V Abc transporter COG1132 Cluster_751658 V1255057 MALT K Transcriptional regulator COG2909 Cluster_773782 V1255058 map00310,map00780,map01100 E Peptidase, S9A B C family, catalytic domain protein COG1506 Cluster_661478 V1255059 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_661479 V1255062 CLCAR_1091 T Histidine kinase COG0642 Cluster_661480 V1255064 K Transcriptional regulator, MarR family 0YH1E Cluster_657319 V1255065 SURE map00230,map00240,map00760,map01100,map01110 F Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) COG0496 Cluster_657320 V1255069 S NA 11G8Y Cluster_657321 V1255072 MOD map00340,map00350,map00624,map01120 L DNA methylase COG2189 Cluster_797151 V1255074 S NA 0Y12I Cluster_661483 V1255075 S NA 0ZEYT Cluster_702380 V1255077 FLGJ map00511 N, U flagellar rod assembly protein muramidase flgj COG1705 Cluster_657323 V1255078 S SusD family 0YPW2 Cluster_755120 V1255079 TELA P Resistance protein COG3853 Cluster_734834 V1255081 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_657324 V1255083 SENX3 map02020 T Histidine kinase 0XNMH Cluster_777500 V1255085 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_868037 V1255088 S Peptidase m28 COG2234 Cluster_657325 V1255090 V Inherit from bactNOG: (ABC) transporter COG1132 Cluster_661487 V1255091 V Eco57I restriction endonuclease COG0827 Cluster_692267 V1255092 ECFA1 map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_661488 V1255093 S fad dependent oxidoreductase COG2509 Cluster_661489 V1255094 UPPP map00550 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) COG1968 Cluster_661490 V1255095 LPDA map00010,map00020,map00260,map00280,map00620,map01100,map01110,map01120 C dihydrolipoyl dehydrogenase COG1249 Cluster_661491 V1255096 M NLP P60 protein COG0791 Cluster_661492 V1255097 PURB map00230,map00250,map01100,map01110 F Adenylosuccinate lyase COG0015 Cluster_661493 V1255098 T Histidine kinase 0XNMH Cluster_661494 V1255099 S NA 0Y12I Cluster_661495 V1255100 RPOD map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_661496 V1255101 ALDA map00620,map00630,map01120 C dehydrogenase COG1012 Cluster_661497 V1255104 S Transporter, auxin efflux carrier (AEC) family protein COG0679 Cluster_661498 V1255105 YOEA V Mate efflux family protein COG0534 Cluster_661500 V1255107 map00052,map00511,map00600,map01100 G Glycosyl hydrolases family 2, TIM barrel domain COG3250 Cluster_661501 V1255108 PURL F phosphoribosylformylglycinamidine synthase COG0047 Cluster_661504 V1255111 BGAA map00052,map00511,map00600,map01100 G hydrolase, family 2 COG3250 Cluster_661505 V1255112 SCLAV_3916 U type ii secretion system protein e COG4962 Cluster_661508 V1255115 PIP S Phage infection protein COG1511 Cluster_661509 V1255116 BL01965 S trap transporter, 4tm 12tm fusion protein COG4666 Cluster_770098 V1255117 P faD-dependent pyridine nucleotide-disulfide oxidoreductase COG0607 Cluster_661510 V1255118 LGT M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 Cluster_661512 V1255121 PGSA map00564,map01100 I cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase COG0558 Cluster_661513 V1255122 MRAY map00550,map01100 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) COG0472 Cluster_661514 V1255123 S ragb susd domaiN-containing protein 0XP53 Cluster_840213 V1255126 S NA 0Z55B Cluster_661515 V1255127 K PRD domain COG3711 Cluster_661516 V1255128 K Peptidase S24-like protein COG2932 Cluster_762425 V1255130 S NA 11J6G Cluster_661517 V1255132 V ABC transporter, permease COG0577 Cluster_665681 V1255134 AMYA2 map00500 G alpha amylase, catalytic 1AKVD@sphNOG Cluster_734835 V1255136 CSN1 L CRISPR-associated protein, Csn1 family COG3513 Cluster_661518 V1255137 E dipeptide-binding protein COG0747 Cluster_661519 V1255139 YGEY map00330,map01100,map01110,map01210,map01230 E M20 DapE family protein YgeY COG0624 Cluster_674346 V1255140 S (LipO)protein 0XSFR Cluster_661520 V1255141 ADCR K Transcriptional 0XUB6 Cluster_661521 V1255142 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_751660 V1255143 P Chromate COG2059 Cluster_661522 V1255144 T Anti-feci sigma factor, fecr COG3712 Cluster_678795 V1255146 MGSA map00620 G methylglyoxal synthase COG1803 Cluster_661523 V1255147 MURE map00300,map00550 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_661524 V1255150 L recombinase (Phage integrase family) COG0582 Cluster_661526 V1255152 PACL P Atpase, p-type (Transporting), had superfamily, subfamily ic COG0474 Cluster_665683 V1255153 PRS map00030,map00230,map01100,map01110,map01120,map01230 E, F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_665684 V1255154 TRMFO J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) COG1206 Cluster_661527 V1255155 ACA4 P Calcium-translocating P-type ATPase, PMCA-type COG0474 Cluster_711724 V1255156 FLDA map00960 C L-carnitine dehydratase bile acid-inducible protein F COG1804 Cluster_661528 V1255157 G Major facilitator superfamily MFS_1 COG0477 Cluster_661529 V1255158 T Histidine kinase COG5002 Cluster_661530 V1255159 map02010 V ABC transporter transmembrane region COG1132 Cluster_661531 V1255160 RHOM_02065 S NA 12C7B Cluster_678796 V1255161 MUTS2 map03430 L muts2 protein COG1193 Cluster_661532 V1255162 S NA 0YC3V Cluster_661533 V1255163 MSRA O reductase COG0229 Cluster_661534 V1255166 M (sortase) family COG3764 Cluster_661535 V1255167 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_665686 V1255170 S s-layer domain-containing protein 0YAE9 Cluster_805280 V1255171 SPOVK O AAA ATPase, central domain protein COG0464 Cluster_661536 V1255172 U Conjugal transfer protein 10082 Cluster_734836 V1255173 YQFA S hemolysin iii COG1272 Cluster_766375 V1255174 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_661537 V1255175 YIBQ M polysaccharide deacetylase COG2861 Cluster_665687 V1255176 MURD map00471,map00550,map01100 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COG0771 Cluster_665688 V1255177 V Beta-lactamase COG1680 Cluster_696042 V1255178 MUTT L hydrolase COG0494 Cluster_715103 V1255180 S integral membrane protein 11RFM Cluster_705492 V1255183 L TrwC relaxase COG0507 Cluster_711725 V1255184 S Cytidylate kinase 0XP28 Cluster_840214 V1255185 S B3 4 domain protein COG3382 Cluster_665690 V1255186 SP_1529 M Polysaccharide Biosynthesis Protein COG2244 Cluster_661538 V1255187 M Sulfatase COG1368 Cluster_661539 V1255188 S Membrane COG3949 Cluster_661540 V1255190 CLPB O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_661541 V1255191 S Membrane COG2510 Cluster_665691 V1255192 LACZ map00052,map00511,map00600,map01100 G beta-galactosidase COG3250 Cluster_661542 V1255193 S ABC transporter COG3845 Cluster_665692 V1255195 S NA 11NI8 Cluster_665693 V1255196 S NA 124TN Cluster_665694 V1255197 J Glutamine amidotransferase COG2071 Cluster_665695 V1255199 YHFX E Racemase COG3457 Cluster_665696 V1255200 S NA 11RZ5 Cluster_665697 V1255202 SG1670 S phage protein COG3646 Cluster_665698 V1255203 GPSA map00564 C NADPH-dependent glycerol-3-phosphate dehydrogenase COG0240 Cluster_687777 V1255204 LPDA map00010,map00020,map00260,map00280,map00620,map01100,map01110,map01120 C dihydrolipoyl dehydrogenase COG1249 Cluster_789381 V1255205 YEEW S NA 17I6N@proNOG Cluster_932252 V1255206 YEEV S Protein of unknown function (DUF1219) 17GDZ@proNOG Cluster_665699 V1255207 S ragb susd domaiN-containing protein 0Z7X3 Cluster_661544 V1255209 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_696043 V1255210 YFCR S Fimbrial 17KT1@proNOG Cluster_665700 V1255211 GLTS E Sodium Glutamate Symporter COG0786 Cluster_665701 V1255212 PATA map00260,map00330,map01100,map01120,map01210,map01230 E Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. Is also able to transaminate cadaverine and, in lower extent, spermidine, but not ornithine (By similarity) COG4992 Cluster_665703 V1255214 S Inherit from COG: domain protein COG1511 Cluster_661545 V1255216 S fad dependent oxidoreductase COG2509 Cluster_665704 V1255217 PUTA map00250,map00330,map01100,map01110 C Dehydrogenase COG1012 Cluster_665705 V1255219 DRAG O ADP-ribosylation crystallin J1 COG1397 Cluster_665706 V1255220 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_665707 V1255222 ASP S Alkaline-shock protein COG1302 Cluster_665708 V1255223 GNTK map00030,map01100,map01110,map01120 G carbohydrate kinase, thermoresistant glucokinase family COG3265 Cluster_665709 V1255225 S NA 11S03 Cluster_665710 V1255226 SURB S G5 domain protein 0ZVV3 Cluster_665711 V1255227 CTPC map00190 P heavy metal translocating P-type ATPase COG2217 Cluster_665712 V1255228 V FtsX-like permease family 0ZW5X Cluster_665713 V1255229 YBFC S NA 1803H@proNOG Cluster_665714 V1255230 LEPB map03060 U Signal peptidase i COG0681 Cluster_665716 V1255233 S transposase, YhgA-like 11S4M Cluster_665717 V1255234 S Rhomboid family COG0705 Cluster_665718 V1255235 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_665719 V1255236 P transporter COG0733 Cluster_665721 V1255238 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_665722 V1255239 MODC map02010 P ABC transporter COG1118 Cluster_793160 V1255240 FEOB P Ferrous iron transport protein B COG0370 Cluster_665723 V1255241 NAGA map00052,map00520,map01110 G GlcNAc 6-P deacetylase COG1820 Cluster_665724 V1255242 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_665725 V1255245 HYDROLASE U Hydrolase COG4940 Cluster_665727 V1255247 map00564,map00730 C fad dependent oxidoreductase COG0579 Cluster_669962 V1255249 T UspA domain-containing protein COG0589 Cluster_665729 V1255250 SP_0498 map00511 G endo-beta-N-acetylglucosaminidase COG4724 Cluster_864053 V1255253 COBD map00860,map01100 H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) COG1270 Cluster_665731 V1255257 S Protein of unknown function (DUF819) 0ZWVY Cluster_665732 V1255258 YIDE P transport protein COG2985 Cluster_917732 V1255259 ABGT H Transporter COG2978 Cluster_665735 V1255266 P membrAne COG2717 Cluster_813301 V1255267 SOJ D Chromosome Partitioning Protein COG1192 Cluster_665736 V1255270 ROCE E amino acid COG0531 Cluster_917733 V1255271 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 C Phosphofructokinase COG0205 Cluster_828666 V1255272 P Sodium/hydrogen exchanger family COG0475 Cluster_665737 V1255273 BIOB map00780,map01100 H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) COG0502 Cluster_669963 V1255275 M peptidase COG0739 Cluster_848137 V1255276 OCAR_7558 map00040,map00270,map01100 G SAF domain protein COG2721 Cluster_669964 V1255277 map00564 C -phosphodiesterase COG0584 Cluster_665739 V1255278 FRVR K frv operon regulatory protein COG3711 Cluster_669965 V1255279 BMUL_4296 G Major facilitator superfamily COG0477 Cluster_665740 V1255280 S Domain of unknown function DUF87 0ZJHN Cluster_665741 V1255281 K HTH_XRE 11IIE Cluster_755121 V1255283 S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) COG0718 Cluster_665742 V1255284 S NA 0YABK Cluster_669966 V1255285 FAT map00061,map01100 I Acyl-ACP thioesterase COG3884 Cluster_669967 V1255286 CNA M domain protein 0ZWTG Cluster_665743 V1255287 TRMD map00900,map01100,map01110 J Specifically methylates guanosine-37 in various tRNAs (By similarity) COG0336 Cluster_665744 V1255289 map00330,map01110,map01230 E Ornithine Cyclodeaminase COG2423 Cluster_665745 V1255290 GCD map00030,map01100,map01110 G Dehydrogenase COG4993 Cluster_665746 V1255291 YADC U fimbrial-like protein YadC 17HHX@proNOG Cluster_665747 V1255292 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_669969 V1255295 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_665748 V1255297 S NA 11NX4 Cluster_669970 V1255298 S NA 11V19 Cluster_669971 V1255301 LDTA S ErfK YbiS YcfS YnhG COG1376 Cluster_665750 V1255303 FUMC map00020,map00720,map01100,map01110,map01120,map05200,map05211 C fumarate hydratase class II COG0114 Cluster_665751 V1255304 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_665753 V1255306 map00730,map04122 E Cysteine desulfurase COG1104 Cluster_665754 V1255307 map02010 P periplasmic solute binding protein COG0803 Cluster_665755 V1255308 L Dna topoisomerase COG0550 Cluster_734837 V1255310 RECT L recT protein COG3723 Cluster_669972 V1255314 CYNR K Transcriptional regulator 16SDH@proNOG Cluster_665756 V1255317 S RumE protein 0Z8VP Cluster_669975 V1255324 PEPP E peptidase, M24 COG0006 Cluster_669976 V1255325 FTSW map04112 D cell division protein FtsW COG0772 Cluster_669977 V1255326 CINA H competence damage-inducible protein COG1546 Cluster_665757 V1255328 M Glycosyl transferase, family 2 COG1216 Cluster_669978 V1255330 BPEB P Transporter hydrophobe amphiphile efflux-1 (HAE1) family COG0841 Cluster_669979 V1255331 PHOH T Phoh family COG1702 Cluster_665758 V1255332 CTPC map00190 P heavy metal translocating p-type ATPase COG2217 Cluster_929036 V1255333 E peptidase, M24 COG0006 Cluster_813302 V1255334 GCA map00350,map00362,map00627,map00642,map00903,map01120 L Transferase COG0663 Cluster_687780 V1255336 YQGX map00620 Q domain protein COG0491 Cluster_762427 V1255337 MTNN map00270,map01100 F Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) COG0775 Cluster_665759 V1255338 HLY map04621 S Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation 0XQPX Cluster_669980 V1255339 LACZ map00052,map00511,map00600,map01100 G beta galactosidase small chain COG3250 Cluster_669981 V1255341 map02010 P Periplasmic binding protein 0XRC7 Cluster_669982 V1255344 G transporter major facilitator family protein 0ZWFP Cluster_669983 V1255345 MALC map02010 P permease protein COG1175 Cluster_669984 V1255346 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_669985 V1255347 RLX U relaxase mobilization nuclease domain protein COG3843 Cluster_669986 V1255348 P tonB-dependent Receptor 0XP5Y Cluster_669987 V1255350 map02010 P Cobalt transport protein COG0619 Cluster_748239 V1255351 LGT M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 Cluster_665761 V1255353 CDR P pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_669988 V1255354 L CHC2 zinc finger domain protein 11GE1 Cluster_669989 V1255355 FUSA2 J Translation elongation factor COG0480 Cluster_669990 V1255356 S Membrane 0XQTX Cluster_669991 V1255357 GLSA map00250,map00330,map00471,map00910,map01100,map01120,map04724,map04727,map04964 E Glutaminase COG2066 Cluster_696044 V1255358 NFO map03410 L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) COG0648 Cluster_669993 V1255360 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_669994 V1255361 PLAV_1224 S NA 0ZTDK Cluster_669996 V1255364 PG0695 M major outer membrane protein OmpA 11X18 Cluster_669997 V1255366 C Hydrogenase large subunit domain protein COG4624 Cluster_669998 V1255367 map00903,map01040 Q Thioesterase COG3208 Cluster_670000 V1255370 S Ragb susd domain-containing protein 0Y63T Cluster_670001 V1255373 L Resolvase COG1961 Cluster_670002 V1255374 G Alpha-1,2-mannosidase COG3537 Cluster_725034 V1255375 DXS map00730,map00900,map01100,map01110 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) COG1154 Cluster_670003 V1255376 S DNA-binding protein COG3943 Cluster_670005 V1255378 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_670006 V1255379 BIOA map00250,map00260,map00330,map00410,map00640,map00650,map00780,map01100 H Catalyzes two activities which are involved in the biotine biosynthesis the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism, and the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA) (By similarity) COG0502 Cluster_670007 V1255380 S NA 0YPEU Cluster_670008 V1255382 CWLM M n-acetylmuramoyl-l-alanine amidase COG3409 Cluster_670009 V1255384 S NA 0Y1MD Cluster_670010 V1255385 AROA map00400,map01100,map01110,map01230 E 3-phosphoshikimate 1-carboxyvinyltransferase COG0128 Cluster_824877 V1255386 SRTD M Sortase family COG3764 Cluster_670011 V1255388 map02010 V ABC transporter transmembrane region COG1132 Cluster_715106 V1255390 GCVT map00260,map00670,map00910,map01100 E The glycine cleavage system catalyzes the degradation of glycine (By similarity) COG0404 Cluster_832426 V1255393 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_670013 V1255394 APPC map02010 P ABC superfamily ATP binding cassette transporter ABC protein COG1173 Cluster_670014 V1255395 S NA 17SFZ@proNOG Cluster_859720 V1255396 RPLM map03010 J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) COG0102 Cluster_670015 V1255398 ADHE map00010,map00051,map00071,map00350,map00362,map00363,map00591,map00620,map00621,map00622,map00625,map00626,map00650,map01100,map01110,map01120 C alcohol dehydrogenase COG1454 Cluster_699331 V1255401 T Toxic component of a toxin-antitoxin (TA) module (By similarity) COG2337 Cluster_670017 V1255403 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_670019 V1255405 NAGH map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 S K01197 hyaluronoglucosaminidase EC 3.2.1.35 0XPBQ Cluster_670020 V1255406 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG0194 Cluster_670021 V1255407 YHFE E m42 family COG1363 Cluster_670022 V1255408 V Abc transporter COG1132 Cluster_859721 V1255409 S Glycosyl Hydrolase Family 88 0XPY2 Cluster_670024 V1255411 RPLJ map03010 J 50s ribosomal protein L10 COG0244 Cluster_670026 V1255413 S Ser Thr phosphatase family protein COG1408 Cluster_766377 V1255414 C Flavodoxin COG0716 Cluster_670027 V1255417 YEGQ map05120 O Peptidase U32 COG0826 Cluster_683345 V1255419 S single-strand binding family protein 0YA2Z Cluster_670028 V1255420 GLYQS map00970 J Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) COG0423 Cluster_670029 V1255421 L RNA-directed DNA polymerase COG3344 Cluster_674350 V1255422 YIDE P transport protein COG2985 Cluster_670030 V1255423 PAAA map00360,map01120 Q phenylacetate-CoA oxygenase PaaG subunit COG3396 Cluster_670031 V1255424 RECJ map03410,map03430,map03440 L Exonuclease RecJ COG0608 Cluster_674351 V1255426 S NA 1015R Cluster_674352 V1255427 CNA M domain protein 0ZWTG Cluster_670032 V1255429 S Toxin-antitoxin system, toxin component 0XRRU Cluster_670033 V1255430 YGHZ map00051,map00363,map00591,map00625,map00650,map01100,map01120 C aldo keto reductase COG0667 Cluster_738175 V1255431 PURB map00230,map00250,map01100,map01110 F Adenylosuccinate lyase COG0015 Cluster_670034 V1255432 DEGV S degv family COG1307 Cluster_674353 V1255435 S NA 0YZ82 Cluster_670036 V1255436 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_670037 V1255437 MGLB map02010,map02030 G Periplasmic binding protein LacI transcriptional regulator COG1879 Cluster_917734 V1255438 L Resolvase COG1961 Cluster_670038 V1255439 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily COG1368 Cluster_674354 V1255440 HEMC map00860,map01100,map01110 H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) COG0181 Cluster_670039 V1255441 V ABC transporter COG1132 Cluster_670040 V1255442 UVRD map03420,map03430 L ATP-dependent DNA helicase pcra COG0210 Cluster_670041 V1255443 S -acetyltransferase 11VMI Cluster_674355 V1255447 S NA 0Z51W Cluster_670042 V1255448 DACB map00550 M d-alanyl-d-alanine carboxypeptidase COG2027 Cluster_751662 V1255449 S SusD family 10R7K Cluster_670043 V1255451 PURM map00230,map01100,map01110 F Phosphoribosylformylglycinamidine cyclo-ligase COG0150 Cluster_674356 V1255454 L site-specific recombinase, phage integrase family 127XR Cluster_670044 V1255456 DDPF P ABC transporter COG1124 Cluster_731611 V1255457 S Transcriptional regulator 11MVX Cluster_755123 V1255458 ATPB map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) COG1156 Cluster_678797 V1255459 S oxidoreductase 0XP5M Cluster_670045 V1255460 map00500 G Glucan 1,3-beta-glucosidase COG2730 Cluster_715107 V1255461 VC1767 S Protein of unknown function DUF262 COG1479 Cluster_715108 V1255463 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_674357 V1255464 POTB map02010 P ABC transporter, permease COG1176 Cluster_758648 V1255465 S UPF0597 protein COG3681 Cluster_692269 V1255467 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_670046 V1255468 S NA 0ZY0U Cluster_674358 V1255471 MNME S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 Cluster_674359 V1255472 S NA 101UU Cluster_670047 V1255473 RUMAL_0348 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_762428 V1255474 M Polysaccharide Biosynthesis Protein COG2244 Cluster_741593 V1255475 map00051,map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 G Glycosyl hydrolase family 20 COG3525 Cluster_770101 V1255477 RESC O cytochrome C COG0755 Cluster_674360 V1255478 K Transcriptional regulator, TetR family 11IXV Cluster_801086 V1255480 G glycoside hydrolase, family 20 0ZVD2 Cluster_832427 V1255481 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_670048 V1255484 LACZ map00052,map00511,map00600,map01100 G beta galactosidase small chain COG3250 Cluster_793161 V1255485 S NA 0Z398 Cluster_674362 V1255486 HEMN map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_702382 V1255487 map02010 P Permease protein COG0609 Cluster_670049 V1255490 MALQ map00500,map01100,map01110 G 4-alpha-glucanotransferase COG1640 Cluster_670050 V1255493 PDXS map00750 H Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) COG0214 Cluster_725036 V1255494 L DNA alkylation repair enzyme COG4912 Cluster_670051 V1255495 YQFF S Metal Dependent Phosphohydrolase COG1480 Cluster_809314 V1255497 COMEB map00240,map01100 F deaminase COG2131 Cluster_674364 V1255498 GLK map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G ROK family COG1940 Cluster_832428 V1255500 MT3733 map00510,map01100 M Glycosyl transferase COG0463 Cluster_670052 V1255502 C Aldo Keto reductase COG1453 Cluster_674365 V1255503 S NA 11NI8 Cluster_674366 V1255504 FRUA map00051,map01100,map02060 G PTS System COG1762 Cluster_674367 V1255505 YOCS S Bile acid COG0385 Cluster_674368 V1255506 FNI map00900,map01100,map01110 C Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) COG1304 Cluster_674369 V1255507 HSDS V restriction modification system DNA specificity domain COG0732 Cluster_674370 V1255508 YTFP S hi0933 family COG2081 Cluster_674371 V1255510 DNAQ2 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit epsilon COG0847 Cluster_872015 V1255512 FBPA K Fibronectin-binding protein COG1293 Cluster_674372 V1255513 G carbohydrate kinase, YjeF related protein COG0063 Cluster_683346 V1255515 MURI map00230,map00240,map00471,map01100 M Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) COG0796 Cluster_674374 V1255516 DPPC P ABC transporter permease protein COG1173 Cluster_674375 V1255518 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_674376 V1255519 T ATPase histidine kinase DNA gyrase B HSP90 domain protein COG5002 Cluster_708568 V1255520 AROE map00400,map01100,map01110,map01230 E shikimate dehydrogenase COG0169 Cluster_674377 V1255523 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_674378 V1255524 HEMA map00860,map01100,map01110 H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) COG0373 Cluster_734839 V1255527 MAF D MAF-like protein COG0424 Cluster_674381 V1255529 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_721667 V1255530 PAAI2 map00360 S Thioesterase superfamily protein 1292Y Cluster_674382 V1255531 PUTP E Sodium proline symporter COG0591 Cluster_674383 V1255533 SUFB O FeS assembly protein SUFB COG0719 Cluster_674384 V1255534 PEPQ map00310,map00780,map01100 E peptidase M24 COG0006 Cluster_674385 V1255535 TRPE map00400,map01100,map01110,map01230 E anthranilate synthase component I COG0147 Cluster_674386 V1255536 HTH_1030 map02020 T Sigma-54 interaction domain protein COG2204 Cluster_674387 V1255537 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_674389 V1255539 YJFP S Esterase COG1073 Cluster_674390 V1255540 RHAB map00040,map00051 G Rhamnulokinase COG1070 Cluster_758649 V1255541 BL00235 map00240,map00250,map00330,map01100,map01110,map01230 I domain protein COG0439 Cluster_674391 V1255542 S Lpxtg-motif cell wall anchor domain protein 0XQBH Cluster_674392 V1255544 PBUX F permease COG2233 Cluster_715109 V1255545 COAD map00770,map01100 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) COG0669 Cluster_674393 V1255546 M domain protein COG4932 Cluster_884284 V1255549 RPSM map03010 J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits COG0099 Cluster_868042 V1255550 RPSK map03010 J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) COG0100 Cluster_674396 V1255551 RARA L recombination factor protein RarA COG2256 Cluster_674397 V1255552 SLGD_00064 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_674398 V1255553 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_674399 V1255554 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_674400 V1255555 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_744891 V1255557 V abc transporter atp-binding protein COG1131 Cluster_674401 V1255558 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_718366 V1255560 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_674404 V1255562 PGN_0950 V ABC transporter, ATP-binding protein COG1132 Cluster_674405 V1255563 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_817051 V1255564 VIRE2 S Virulence-associated protein e COG5545 Cluster_674406 V1255565 S NA 0ZHSE Cluster_755124 V1255566 GMHA map00540,map01100 G Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) COG0279 Cluster_721668 V1255567 L Transposase, Mutator family COG3328 Cluster_674407 V1255569 S Radical SAM superfamily COG0641 Cluster_678798 V1255571 map00311,map00312,map01110,map02020 V Beta-lactamase COG2367 Cluster_674409 V1255572 ILVY K transcriptional regulator COG0583 Cluster_674410 V1255573 M Phosphate-selective porin O and P 0Z9S5 Cluster_674411 V1255575 L DNA helicase COG1112 Cluster_711726 V1255576 S 'Phage' integrase family 0YKE0 Cluster_674412 V1255577 M Sulfatase COG1368 Cluster_674413 V1255578 XYNB map00500,map00520,map01100 G Xylan 1,4-beta-xylosidase (EC 3.2.1.37) COG3664 Cluster_711727 V1255579 AROB map00230,map00400,map01100,map01110,map01230 E 3-dehydroquinate synthase COG0337 Cluster_678799 V1255580 E, P Binding-protein-dependent transport system inner membrane component COG1173 Cluster_884285 V1255581 EFP J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) COG0231 Cluster_678800 V1255584 HLY map00270,map00450,map00920,map01100,map01110,map01230 E Aminotransferase class I and II COG1168 Cluster_674414 V1255585 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_859722 V1255586 LIVK map02010 E extracellular ligand-binding receptor COG0683 Cluster_674415 V1255587 M hydrolase, family 25 COG3757 Cluster_738177 V1255589 YAZA L domain protein COG2827 Cluster_674417 V1255590 ADE map00230,map01100 F adenine deaminase COG1001 Cluster_674418 V1255592 M Glycosyl transferase (Group 1 11H1P Cluster_828670 V1255595 PG0695 M major outer membrane protein OmpA 11X18 Cluster_738178 V1255596 map00051,map01100,map02060 G PTS IIA-like nitrogen-regulatory protein PtsN COG1762 Cluster_674419 V1255597 S phage portal protein, SPP1 0ZZDC Cluster_708569 V1255600 DPM1 map00510,map01100 M dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) 0XQRC Cluster_674421 V1255604 V Mate efflux family protein COG0534 Cluster_820895 V1255605 S Metal dependent hydrolase COG2220 Cluster_921643 V1255606 DEGV S degv family COG1307 Cluster_678801 V1255607 S synthase 0ZX3G Cluster_674423 V1255611 map02010 V abc transporter COG1132 Cluster_785368 V1255612 S Protein of unknown function (DUF1700) 11XIW Cluster_741594 V1255613 map00052,map01100,map02060 G PTS system, galactitol-specific IIc component COG3775 Cluster_678803 V1255615 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_678804 V1255616 PPSA map00620,map00680,map00720,map01100,map01120 G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) COG0574 Cluster_678805 V1255617 PGCA map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_702383 V1255618 TRML map04122 J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) COG0219 Cluster_678806 V1255619 S NA 0ZHU9 Cluster_705493 V1255620 M glycosyl transferase group 1 0ZWDI Cluster_801087 V1255622 LEPB map03060 U Signal peptidase i COG0681 Cluster_758650 V1255623 HUTU map00340,map01100 E Urocanate hydratase COG2987 Cluster_678808 V1255624 K Transcriptional regulator, ARAC family COG2207 Cluster_674424 V1255625 ACDA map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I acyl-CoA dehydrogenase COG2025 Cluster_678809 V1255626 MRCA map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_674425 V1255629 S NA 123IR Cluster_809316 V1255632 S NA 0ZE04 Cluster_678811 V1255633 S Phosphotransferase System Component 0ZVJW Cluster_678812 V1255634 T Histidine kinase 16VMX@proNOG Cluster_678813 V1255635 ETFB map00910 C Electron transfer flavoprotein COG2086 Cluster_868046 V1255636 C Nitroreductase COG0778 Cluster_801088 V1255640 S NA 0ZHU9 Cluster_728314 V1255641 K RNA Polymerase 11YW1 Cluster_678814 V1255642 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_678815 V1255643 E, G permease COG0697 Cluster_674426 V1255644 map02010 V abc transporter COG1132 Cluster_674427 V1255645 M Cell wall binding repeat 2-containing protein COG2247 Cluster_678816 V1255646 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_678817 V1255647 TRMFO J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) COG1206 Cluster_678818 V1255649 PYC map00020,map00620,map00720,map01100,map01120,map01230 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) COG1038 Cluster_770102 V1255651 ADDB L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination COG3857 Cluster_678820 V1255654 PPK1 map00190,map03018 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) COG0855 Cluster_876097 V1255655 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_678821 V1255656 ACA4 P Calcium-translocating P-type ATPase, PMCA-type COG0474 Cluster_678822 V1255657 M YD repeat protein COG3209 Cluster_674429 V1255661 NUDC map00760,map04146 L nadh pyrophosphatase COG2816 Cluster_828671 V1255663 FUSA2 J Translation elongation factor COG0480 Cluster_678823 V1255664 XFP map00030,map00680,map00710,map01100,map01120 G Phosphoketolase COG3957 Cluster_678824 V1255665 S plasmid recombination enzyme 0XPM6 Cluster_793162 V1255667 S phage plasmid primase, p4 family COG3378 Cluster_699332 V1255668 PFL C formate acetyltransferase COG1882 Cluster_678825 V1255669 YFAL M, U outer membrane autotransporter COG3468 Cluster_728315 V1255671 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_678827 V1255674 HGDB E dehydratase COG1775 Cluster_678828 V1255675 RHOM_13740 I Phospholipase D domain protein COG1502 Cluster_678830 V1255678 map02010,map02030 P Periplasmic binding protein LacI transcriptional regulator COG1879 Cluster_696046 V1255680 MNTH P H( )-stimulated, divalent metal cation uptake system (By similarity) COG1914 Cluster_678832 V1255682 O DnaJ domain protein COG2214 Cluster_678834 V1255684 E Lipolytic protein, GDSL COG2755 Cluster_789382 V1255686 CSHA map03018 L atp-dependent rna helicase COG0513 Cluster_789383 V1255687 APBE M thiamine biosynthesis lipoprotein apbE COG1477 Cluster_731613 V1255688 SUFB O FeS assembly protein SUFB COG0719 Cluster_678836 V1255690 NUOL map00190,map00910,map01100 C subunit l COG1009 Cluster_678837 V1255691 S NA 0ZVRE Cluster_678838 V1255692 G Major Facilitator COG2814 Cluster_678839 V1255693 G S-layer domain protein 0XQ2J Cluster_678840 V1255696 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4973 Cluster_678841 V1255697 SLGD_00086 S Ser Thr phosphatase family protein COG1409 Cluster_725037 V1255698 S Uncharacterised ArCR, COG2043 COG2043 Cluster_848138 V1255699 S abc transporter atp-binding protein 11J2E Cluster_892327 V1255701 DPNA L helicase COG4646 Cluster_678842 V1255702 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_678843 V1255703 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_728316 V1255705 S lipolytic protein G-D-S-L family 0XT5K Cluster_699333 V1255706 YIAO G transporter COG1638 Cluster_678845 V1255709 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_678846 V1255710 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_683347 V1255712 ATPA map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) COG1155 Cluster_678847 V1255713 SERC map00260,map00680,map00750,map01100,map01120,map01230 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) COG1932 Cluster_683348 V1255714 S NA 0XWEM Cluster_683349 V1255718 S Rib/alpha-like repeat 10008 Cluster_678849 V1255719 S STN 0ZPQX Cluster_708570 V1255721 BDHA map00051,map00363,map00591,map00625,map00650,map01100,map01120 C alcohol dehydrogenase COG1979 Cluster_678850 V1255723 S tetrapyrrole methylase COG3956 Cluster_683352 V1255724 HTPG map04141,map04151,map04612,map04621,map04626,map04914,map04915,map05200,map05215 O Molecular chaperone. Has ATPase activity (By similarity) COG0326 Cluster_785369 V1255725 HYDE map00780,map01100 H radical SAM domain protein COG0502 Cluster_678851 V1255730 REPW S Plasmid Encoded RepA Protein 16TFD@proNOG Cluster_755125 V1255731 MNME S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 Cluster_678852 V1255733 SPAK T Histidine kinase COG0642 Cluster_678853 V1255734 HLYX P CBS domain protein COG1253 Cluster_678854 V1255738 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_683353 V1255740 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_725038 V1255742 DOC S Death-On-Curing Family COG3654 Cluster_678855 V1255744 PRFC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) COG4108 Cluster_678856 V1255745 S NA 0ZX6K Cluster_699334 V1255746 ICD map00020,map00290,map00480,map00720,map01100,map01110,map01120,map01210,map01230,map04146 C Isocitrate dehydrogenase, NAD-dependent COG0473 Cluster_741596 V1255747 map02010 P ABC transporter COG1840 Cluster_678858 V1255750 TRSE U traE protein COG3451 Cluster_744892 V1255751 TIG O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COG0544 Cluster_683354 V1255752 S Oligopeptide transporter, Opt family COG1297 Cluster_678859 V1255753 V ABC transporter COG1132 Cluster_678860 V1255754 M, U Inherit from COG: Outer membrane autotransporter COG4625 Cluster_683355 V1255755 FTSE map02010 D Cell division ATP-binding protein ftsE COG2884 Cluster_683356 V1255756 OPPA map02010 E Extracellular solute-binding protein, family 5 COG4166 Cluster_734841 V1255757 M dolichyl-phosphate-mannose-protein mannosyltransferase COG1807 Cluster_755126 V1255758 D Chromosome Partitioning Protein COG1192 Cluster_683357 V1255759 M domain protein COG4932 Cluster_696047 V1255760 PSTA map02010 P phosphate abc transporter COG0581 Cluster_678861 V1255761 S NA 11Y9F Cluster_687781 V1255762 P Chromate COG2059 Cluster_734842 V1255764 ARSB P transporter COG1055 Cluster_683358 V1255765 VIRE L Virulence-associated protein e COG5545 Cluster_683359 V1255767 S --O-antigen 11XB6 Cluster_678863 V1255768 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_718367 V1255769 RNFC C Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) COG4656 Cluster_678864 V1255772 V ABC transporter COG1132 Cluster_678865 V1255773 map02010 V ABC transporter COG1132 Cluster_718368 V1255774 S NA 0ZX41 Cluster_683362 V1255775 ASP S alkaline shock protein COG1302 Cluster_683363 V1255776 P Chromate transport protein COG2059 Cluster_683364 V1255778 YGBK S Type III effector Hrp-dependent COG3395 Cluster_683365 V1255779 map00240,map01100 S Cytidylate kinase 0XP28 Cluster_683367 V1255781 U hydrolase, family 8 0Y1JM Cluster_678866 V1255782 YJGR S ATP-binding protein COG0433 Cluster_678868 V1255784 S NA 0ZSQZ Cluster_683368 V1255786 S Sigma-70, region 4 1194K Cluster_678869 V1255787 CPS4C M biosynthesis protein COG3944 Cluster_683369 V1255788 S ragb susd domaiN-containing protein 0XP1B Cluster_678871 V1255792 THIN map00730,map01100 H thiamine COG1564 Cluster_683372 V1255794 YOCR P Transporter COG0733 Cluster_728317 V1255795 MURR K Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) COG1737 Cluster_683373 V1255796 S SusD family 0ZI89 Cluster_683374 V1255797 ECFA1 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_683375 V1255799 ILVA map00260,map00290,map01100,map01110,map01230 E Pyridoxal-phosphate dependent enzyme COG1171 Cluster_711728 V1255800 S (LipO)protein 11J26 Cluster_415814 V1025401 S 40-residue yvtn family beta-propeller repeat protein COG3391 Cluster_415815 V1025402 U, W Inherit from COG: domain protein COG5295 Cluster_415816 V1025405 YHJK T Diguanylate cyclase phosphodiesterase 16PBJ@proNOG Cluster_415817 V1025407 S NA 11RGQ Cluster_765324 V1025408 S selenoprotein B, glycine betaine sarcosine D-proline reductase 123JW Cluster_444565 V1025414 OPCA G OpcA protein COG3429 Cluster_639993 V1025416 COF S hydrolase COG0561 Cluster_506680 V1025418 C Nitroreductase COG0778 Cluster_415818 V1025419 YFAA S Uncharacterized protein conserved in bacteria (DUF2138) COG4685 Cluster_613283 V1025423 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_808243 V1025428 YTFP S hi0933 family COG2081 Cluster_417568 V1025429 AMBT_05390 L Integrase catalytic subunit COG4584 Cluster_417569 V1025433 G transporter 0XP7I Cluster_575683 V1025434 YUSF L Toprim domain protein COG1658 Cluster_417570 V1025435 S NA 17QI6@proNOG Cluster_475256 V1025436 YLEB S Outer surface protein COG3589 Cluster_454564 V1025437 YICG S Membrane COG2860 Cluster_417571 V1025438 GAPA map00010,map01100,map01110,map01120,map01230,map04066,map05010 G Glyceraldehyde-3-phosphate dehydrogenase, type I COG0057 Cluster_471005 V1025439 BMUL_3410 S isomerase 17GWR@proNOG Cluster_419296 V1025441 FHUA P receptor COG1629 Cluster_417572 V1025443 M glycosyl transferase family 17SGG@proNOG Cluster_419297 V1025448 CSN1 L CRISPR-associated protein, Csn1 family COG3513 Cluster_419298 V1025450 PLSC map00561,map00564,map01100 I Acyl-transferase 0Z3QU Cluster_419299 V1025451 MMPL3 H MMPL domain protein COG2409 Cluster_417573 V1025452 NDH map00190 C NADH dehydrogenase COG1252 Cluster_533772 V1025453 S Cupin 2, conserved barrel domain protein 11XWV Cluster_419300 V1025455 HEMB map00860,map01100,map01110 H delta-aminolevulinic acid dehydratase COG0113 Cluster_419302 V1025459 L helicase domain protein COG0553 Cluster_419303 V1025460 Q non-ribosomal peptide synthetase COG3319 Cluster_419304 V1025463 SCLAV_2829 S Sec-C motif domain protein 100MK Cluster_419305 V1025464 EAEH map05100,map05130 S K13735 adhesin invasin 16SKU@proNOG Cluster_419306 V1025466 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_847177 V1025467 S NA 0ZHU9 Cluster_858502 V1025469 S NA 0ZHU9 Cluster_808244 V1025470 DARB map00061,map01100 I synthase III COG0332 Cluster_421158 V1025472 CAFA map03018 J ribonuclease COG1530 Cluster_819734 V1025481 RPMG map03010 J 50S ribosomal protein L33 1250Q Cluster_421159 V1025482 DEAD map03018 L atp-dependent rna helicase COG0513 Cluster_730751 V1025486 S NA 0YIA5 Cluster_656187 V1025487 S Relaxase mobilization nuclease 0Y9PG Cluster_460472 V1025488 YYDK K transcriptional regulator COG2188 Cluster_423010 V1025489 map00230,map00240 F 2',3'-cyclic-nucleotide 2'-phosphodiesterase EC 3.1.4.16 COG0737 Cluster_452524 V1025490 S NA 0ZHU9 Cluster_421160 V1025491 S NA 16S77@proNOG Cluster_717515 V1025492 S histone family protein nucleoid-structuring protein h-ns COG2916 Cluster_421161 V1025495 FLHA map02040 N Flagellar biosynthesis protein flha COG1298 Cluster_827739 V1025496 S NA 11ENN Cluster_452525 V1025498 TRAJ S conjugative transposon 0XP5P Cluster_765326 V1025499 S NA 125T8 Cluster_620760 V1025500 RBPA S NA 11U3N Cluster_668880 V1025501 CYOA map00190,map00910,map01100 C oxidase) subunit II COG1622 Cluster_710841 V1025504 RBSC-1 S ABC transporter, permease COG4603 Cluster_424792 V1025505 AHPC O domain protein COG0678 Cluster_804280 V1025509 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_743952 V1025513 S (LipO)protein 0YHGC Cluster_747365 V1025514 ZWF map00030,map00480,map01100,map01110,map01120 G glucose-6-phosphate 1-dehydrogenase COG0364 Cluster_423013 V1025515 NUOD map00190,map00910,map01100 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) COG0852 Cluster_562978 V1025517 GLBO O K06886 hemoglobin COG2346 Cluster_581989 V1025519 S hydrolase) protein 1738H@proNOG Cluster_776559 V1025520 map02020 T regulatoR COG2197 Cluster_867075 V1025521 S NA 11NH0 Cluster_423014 V1025522 SASC S surface protein 11FPX Cluster_423015 V1025524 FAS map00061,map00350,map00362,map00627,map00642,map00903,map01100,map01120 I synthase COG4982 Cluster_423016 V1025528 L Pfam:Transposase_7 COG4644 Cluster_854706 V1025530 L Integrase COG0582 Cluster_423017 V1025531 L helicase COG4646 Cluster_444566 V1025533 PORG map00020,map00720,map01100,map01120 C oxidoreductase COG1014 Cluster_424793 V1025538 S Protein of unknown function (DUF2807) 11JCU Cluster_717516 V1025539 NUCA map04210 F DNA RNA NON-specific endonuclease COG1864 Cluster_424794 V1025540 S domain protein 0YF83 Cluster_424795 V1025543 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_424796 V1025544 MPRA O Peptidase S8 and S53 subtilisin kexin sedolisin COG1404 Cluster_424797 V1025545 S NA 0ZUGA Cluster_695160 V1025546 S NA 0ZHU9 Cluster_426677 V1025547 TRXB map00240,map00450 O pyridine nucleotide-disulfide oxidoreductase COG0492 Cluster_446581 V1025548 U, W Inherit from COG: domain protein COG5295 Cluster_424798 V1025554 S NA 12BX4 Cluster_652022 V1025555 NASF map00860,map01100,map01110 H c-methyltransferase COG0007 Cluster_704636 V1025558 L integrase family 175MM@proNOG Cluster_426678 V1025559 PHOB map00627,map00790,map01100,map01120,map02020 P alkaline phosphatase COG1785 Cluster_511900 V1025562 S NA 0Y4DT Cluster_743954 V1025565 FETB map02010 P Periplasmic binding protein COG4607 Cluster_754183 V1025566 YHHJ map02010 V transporter COG0842 Cluster_458415 V1025567 K Tetr family transcriptional regulator COG1309 Cluster_426679 V1025568 PSTS map02010,map02020,map05152 P Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) COG0226 Cluster_631972 V1025569 YIHX map00361,map00625,map01100,map01120 S HAD-superfamily hydrolase subfamily IA variant 3 COG1011 Cluster_895424 V1025570 YIHW K Transcriptional regulator COG1349 Cluster_572457 V1025572 DPNA L helicase COG4646 Cluster_710842 V1025573 ISPD map00900,map01100,map01110 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COG1211 Cluster_454565 V1025574 S NA 17B62@proNOG Cluster_426680 V1025575 U, W Pfam:YadA COG5295 Cluster_426681 V1025576 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_426682 V1025577 YEGQ map05120 O Peptidase U32 COG0826 Cluster_750745 V1025578 ATPC map00190,map00195,map01100 C ATP synthase, Delta Epsilon 11YZG Cluster_525427 V1025579 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_466712 V1025581 WECG M Glycosyl transferase, wecb taga cpsf family COG1922 Cluster_466713 V1025582 YDJM S Membrane-bound metal-dependent hydrolase COG1988 Cluster_428595 V1025583 L Integrase COG0582 Cluster_501749 V1025584 S NA 11HGS Cluster_428596 V1025587 S tonB-dependent Receptor 0YAYV Cluster_428598 V1025590 GG9_0942 L transposase COG2801 Cluster_668881 V1025599 S NA 11NUB Cluster_844233 V1255801 TRXB map00240,map00450 O thioredoxin reductase COG0492 Cluster_678872 V1255803 YLBB V abc transporter permease protein COG0577 Cluster_678873 V1255804 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_683376 V1255805 NADE map00760,map01100 H Nad synthetase COG0388 Cluster_678874 V1255806 KTRB P Potassium uptake protein COG0168 Cluster_678875 V1255807 MEND map00130,map01100,map01110 H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) COG1165 Cluster_678876 V1255808 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_702385 V1255809 SIGB K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG1191 Cluster_683377 V1255810 HRCA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) COG1420 Cluster_683378 V1255811 GLGA map00500,map01100,map01110,map04973 G Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) COG0297 Cluster_773783 V1255815 S conjugation system ATPase, TraG family 0XSHU Cluster_683381 V1255816 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_683382 V1255818 CYSN map00230,map00450,map00920,map01100,map01120 P May be the GTPase, regulating ATP sulfurylase activity (By similarity) COG2895 Cluster_683383 V1255821 G sugar (Glycoside-Pentoside-Hexuronide) transporter COG2211 Cluster_683385 V1255823 S RagB SusD domain-containing protein 101CE Cluster_718369 V1255824 S hydrolase COG0561 Cluster_789384 V1255826 S surface layer protein 0ZYVX Cluster_734843 V1255828 P tonB-dependent Receptor COG4771 Cluster_683386 V1255829 YEGQ map05120 O Peptidase U32 COG0826 Cluster_683387 V1255830 S NA 0Z7FX Cluster_683388 V1255831 ACA4 P Calcium-translocating P-type ATPase, PMCA-type COG0474 Cluster_687782 V1255832 NHAA map00680 P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) COG3004 Cluster_917737 V1255833 T regulatoR COG0745 Cluster_683389 V1255834 S NA 0YBKF Cluster_683390 V1255835 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_715113 V1255837 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_683392 V1255838 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_683393 V1255839 HPPA map00190 C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for COG3808 Cluster_777504 V1255840 MUTL map03430 L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) COG0323 Cluster_683396 V1255843 GPMI map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0696 Cluster_683397 V1255844 map00020,map00190,map00623,map00650,map00720,map00984,map01100,map01110,map01120,map02020 C Flavocytochrome c COG1053 Cluster_728318 V1255845 HYPE O hydrogenase expression formation protein (HypE) COG0309 Cluster_683400 V1255848 map02010 P ABC transporter, permease COG1175 Cluster_683402 V1255850 MTLR K TRANSCRIPTIONal COG3711 Cluster_770103 V1255852 RPLS map03010 J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) COG0335 Cluster_683404 V1255853 map00051,map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 G Glycosyl hydrolase family 20 COG3525 Cluster_683405 V1255854 E oligoendopeptidase, m3 family COG1164 Cluster_728319 V1255855 S Ser Thr phosphatase family protein 0ZIA8 Cluster_683406 V1255856 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0587 Cluster_824878 V1255859 YFMR S Abc transporter, ATP-binding protein COG0488 Cluster_683407 V1255862 NRNA J phosphoesterase RecJ domain protein COG0618 Cluster_773784 V1255863 P Rhodanese domain protein COG0607 Cluster_683408 V1255864 RECO L Involved in DNA repair and RecF pathway recombination (By similarity) COG1381 Cluster_683409 V1255865 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_683410 V1255866 K Replication initiation factor COG2946 Cluster_687784 V1255868 D Chromosome segregation protein SMC COG1196 Cluster_805281 V1255871 map03420,map03430 L helicase COG0210 Cluster_805282 V1255873 GLTD C oxidoreductase FAD NAD(P)-binding domain protein COG0543 Cluster_840217 V1255875 RHOM_02065 S NA 12C7B Cluster_683411 V1255878 ACRB V MMPL family COG0841 Cluster_766379 V1255879 S Triose-phosphate Transporter family 0XUIX Cluster_683412 V1255880 RPSB map03010 J 30S ribosomal protein S2 COG0052 Cluster_683413 V1255881 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0587 Cluster_766380 V1255882 THIE map00730,map01100 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) COG0352 Cluster_728321 V1255883 S NA 0XWY0 Cluster_683414 V1255884 PHOP map02020 T Transcriptional regulatory protein, C terminal 11FPD Cluster_683415 V1255885 NHAA map00680 P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) COG3004 Cluster_687785 V1255886 YHAM S UPF0597 protein COG3681 Cluster_699335 V1255887 DET0272 L Phage integrase COG0582 Cluster_683416 V1255888 TERL L Terminase, large subunit COG4626 Cluster_687786 V1255890 CLCAR_1091 T Histidine kinase COG0642 Cluster_683418 V1255892 CLCAR_1091 T Histidine kinase COG0642 Cluster_683420 V1255894 MTAD map00625,map00791,map01120 F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) COG0402 Cluster_781280 V1255895 map00500,map01100,map01110 G, M phosphorylase COG0438 Cluster_793163 V1255898 RPSD map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) COG0522 Cluster_687787 V1255899 AMIA2 map02010 E Oligopeptide-binding protein COG4166 Cluster_687788 V1255900 CAS1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) COG1518 Cluster_683421 V1255901 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_813306 V1255906 S NA 11H0J Cluster_755127 V1255908 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_721670 V1255909 YPHD map02010 G abc transporter COG1172 Cluster_683422 V1255910 T HAMP domain 179GT@proNOG Cluster_687790 V1255911 PDUQ map00010,map00051,map00071,map00350,map00362,map00363,map00561,map00591,map00620,map00621,map00622,map00625,map00626,map00650,map01100,map01110,map01120 C Dehydrogenase COG1454 Cluster_781281 V1255912 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_687791 V1255913 SCLAV_5159 S IgA peptidase M64 0XS18 Cluster_687792 V1255914 MNTH P H( )-stimulated, divalent metal cation uptake system (By similarity) COG1914 Cluster_832429 V1255917 S NADP oxidoreductase coenzyme f420-dependent 0ZHKD Cluster_687795 V1255918 G Glycoside Hydrolase Family 43 0ZW8V Cluster_683423 V1255923 ARGH map00250,map00330,map01100,map01110,map01230 E arginosuccinase COG0165 Cluster_687798 V1255924 MRR V restriction COG1715 Cluster_683424 V1255925 INSQ L transposase COG0675 Cluster_687799 V1255926 S tonB-dependent Receptor 0XNVP Cluster_844234 V1255927 PSAA map02010 P ABC transporter COG0803 Cluster_683425 V1255928 FUSA2 J Translation elongation factor COG0480 Cluster_692271 V1255932 RIMM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) COG0806 Cluster_801089 V1255933 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_683427 V1255934 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_687801 V1255936 SRTC M (sortase) family COG3764 Cluster_687802 V1255938 S Domain of unknown function (DUF2088) COG3875 Cluster_687803 V1255939 FIMZ map02020,map05133 T regulatoR COG2197 Cluster_687804 V1255940 PHEA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydratase COG0077 Cluster_687805 V1255941 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_687808 V1255945 TOPB map03018 L DNA topoisomerase COG0550 Cluster_687809 V1255946 P Arylsulfatase COG3119 Cluster_687810 V1255947 CKL_1893 S Phage replisome organizer 11V35 Cluster_687811 V1255948 ERMX map00340,map00350,map00624,map01120 J rRNA (Adenine-N(6)-)-methyltransferase COG0030 Cluster_687812 V1255949 SDCS P transporter COG0471 Cluster_687813 V1255950 YNBB map00260,map00270,map00450,map01100,map01230 P aluminum resistance protein COG4100 Cluster_687814 V1255954 MIAB J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) COG0621 Cluster_696048 V1255955 L Type II intron maturase COG3344 Cluster_687815 V1255956 S Rib/alpha-like repeat 10008 Cluster_687816 V1255957 T Y_Y_Y domain COG3706 Cluster_699336 V1255958 O peptidase m48, ste24p COG0501 Cluster_766381 V1255959 COMM O Mg chelatase subunit ChlI COG0606 Cluster_687817 V1255960 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_687818 V1255964 BCELL_1025 L Inherit from firmNOG: Transposase COG2801 Cluster_687819 V1255965 METY map00270,map00450,map00920,map01100,map01110,map01230 E O-acetylhomoserine COG2873 Cluster_687820 V1255967 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_687821 V1255968 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_687822 V1255969 UVRD map03420,map03430 L ATP-dependent DNA helicase pcra COG0210 Cluster_755128 V1255971 DSBD O Thiol disulfide interchange protein COG4232 Cluster_738180 V1255972 MDSC S Aminoglycoside phosphotransferase 0XP56 Cluster_687823 V1255973 CSE4 L Crispr-associated protein, cse4 family 0Y6PV Cluster_687825 V1255977 map02010 V ABC transporter COG1131 Cluster_687826 V1255978 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_687827 V1255979 GLF M udp-galactopyranose mutase COG0562 Cluster_687828 V1255980 map03060 U Signal peptidase i COG0681 Cluster_687829 V1255981 CYLB map02010 V Transporter COG0842 Cluster_817055 V1255982 PYRE map00240,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_789386 V1255984 T Regulator COG0745 Cluster_770104 V1255985 FEOA P Ferrous iron transport protein A COG1918 Cluster_762432 V1255986 WLBA map00520 S domain protein COG0673 Cluster_809319 V1255988 XYLB map00040,map01100 C xylulokinase COG1070 Cluster_687830 V1255989 SSCG_04100 S YibE F family protein COG5438 Cluster_687831 V1255992 V ABC transporter transmembrane region COG1132 Cluster_687832 V1255993 YFIH S Multi-copper polyphenol oxidoreductase laccase COG1496 Cluster_738181 V1255994 SP_1548 S NA 0XPRZ Cluster_687833 V1255996 YBDN S Phosphoadenosine phosphosulfate reductase COG3969 Cluster_687834 V1255997 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_687835 V1255998 DAPE1 map00300,map00310,map00330,map00780,map01100,map01110,map01120,map01210,map01230 E peptidase COG0624 Cluster_692272 V1255999 RIMI O ribosomal-protein-alanine acetyltransferase COG0456 Cluster_687836 V1256000 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_687837 V1256002 BMUL_5818 C Iron-sulfur cluster binding protein COG1139 Cluster_692273 V1256003 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_687838 V1256004 V Mate efflux family protein COG0534 Cluster_687839 V1256005 map00052,map00561,map00600,map00603 G alpha-galactosidase COG3345 Cluster_687840 V1256006 T Histidine kinase 11IN2 Cluster_836308 V1256007 PFK map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G K00850 6-phosphofructokinase 1 EC 2.7.1.11 COG0205 Cluster_905084 V1256008 BA_5646 S hydrolase COG0561 Cluster_851925 V1256011 G BNR Asp-box repeat protein COG4692 Cluster_692274 V1256013 PBUG S Xanthine uracil vitamin C permease COG2252 Cluster_864057 V1256014 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_687841 V1256015 M Phage-related minor tail protein COG5280 Cluster_687842 V1256016 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_692275 V1256017 P TonB dependent receptor 0XNNV Cluster_696049 V1256019 map00270,map01100 L C-5 cytosine-specific DNA methylase COG0270 Cluster_817056 V1256020 ATPD map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG1394 Cluster_687843 V1256021 YXIO G major facilitator superfamily COG2270 Cluster_687844 V1256022 DSPB map00051,map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 G Glycoside hydrolase, family 20, catalytic core COG3525 Cluster_692276 V1256024 GPMI map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0696 Cluster_692277 V1256025 PRS map00030,map00230,map01100,map01110,map01120,map01230 E, F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_687845 V1256026 MLTF M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) COG4623 Cluster_692278 V1256027 RC1_2786 L transposase COG5433 Cluster_721671 V1256028 COIA S Competence protein COG4469 Cluster_692279 V1256029 L site-specific recombinase, phage integrase family COG0582 Cluster_687846 V1256030 S Inherit from NOG: repeat protein 11TEE Cluster_687847 V1256031 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_692280 V1256033 ETFA map00910 C Electron transfer flavoprotein COG2025 Cluster_751664 V1256034 PTSI map00051,map01100,map02060 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) COG1080 Cluster_805283 V1256035 S Dehydrogenase COG0300 Cluster_692281 V1256037 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_705495 V1256038 HCP C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) COG1151 Cluster_687848 V1256040 RPRY T regulator COG0745 Cluster_687849 V1256041 map02010,map02020,map05152 P phosphate COG0226 Cluster_748241 V1256043 SUFB O SufB sufD domain protein COG0719 Cluster_692283 V1256044 SCLAV_4837 map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 K ROK family COG1940 Cluster_687850 V1256045 ISPA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_692284 V1256046 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_699337 V1256047 S NA 0XSXN Cluster_692285 V1256049 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_692286 V1256050 PACL P Atpase, p-type (Transporting), had superfamily, subfamily ic COG0474 Cluster_708571 V1256051 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_692287 V1256056 S O-methyltransferase-like protein 106VG Cluster_755129 V1256057 S Protein of unknown function (DUF2851) 0XPBG Cluster_692288 V1256058 GLTD map00250,map00910,map01100,map01110,map01120,map01230 C glutamate synthase (NADPH) small subunit COG0493 Cluster_824879 V1256061 YJCC T domain protein COG4943 Cluster_734844 V1256062 map05100 G s-layer domain protein 11IBF Cluster_718370 V1256064 YHCH G Conserved Protein COG2731 Cluster_692291 V1256065 RPSA map00900,map01100,map01110,map03010 J Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) COG0761 Cluster_692292 V1256066 GLYA map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01230 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) COG0112 Cluster_692293 V1256068 APPB map02010 P Binding-protein-dependent transport systems inner membrane component COG0601 Cluster_692294 V1256069 BCRA map02010 V ABC transporter COG1131 Cluster_687854 V1256071 PPIB O PPIases accelerate the folding of proteins COG0652 Cluster_692295 V1256072 RECT L recT protein COG3723 Cluster_721672 V1256073 PTSP map00051,map01100,map02060 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) COG1080 Cluster_708572 V1256075 C Hydrogenase large subunit domain protein COG4624 Cluster_692296 V1256076 P TonB dependent receptor 0XNNV Cluster_699338 V1256077 map00270,map00330,map00410,map00480,map01100 S synthase 0ZXB1 Cluster_692297 V1256078 S HD domain protein COG1418 Cluster_687855 V1256080 D domain protein 0XTIC Cluster_692298 V1256081 WBYK M Glycosyl transferases group 1 COG0438 Cluster_692299 V1256083 UUP S Abc transporter, ATP-binding protein COG0488 Cluster_692300 V1256085 map03070 U Lytic transglycosylase catalytic 17NGM@proNOG Cluster_721673 V1256087 YAFM L Transposase COG1943 Cluster_696051 V1256088 S NA 0Z78K Cluster_687857 V1256090 LGT M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 Cluster_692301 V1256092 S NA 0ZEYT Cluster_692302 V1256094 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_692303 V1256095 map02010 S ABC-2 type transporter 11HPT Cluster_705497 V1256097 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_692304 V1256098 S fusobacterium outer membrane protein family 0YCEW Cluster_692305 V1256099 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_692307 V1256101 M group 2 family 0XRCB Cluster_692308 V1256102 YBXI map00311,map00312,map01110,map02020 V Beta-lactamase COG2602 Cluster_692309 V1256103 M glycoside hydrolase, family COG5434 Cluster_692310 V1256104 S Membrane COG1738 Cluster_692311 V1256105 M Glycoside hydrolase family 28 COG5434 Cluster_692312 V1256106 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_820896 V1256108 RPLD map03010 J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) COG0088 Cluster_692314 V1256110 RLMB map00340,map00350,map00624,map01120 J RNA methyltransferase TrmH family group 3 COG0566 Cluster_692315 V1256111 C Binding Domain protein 0ZVNA Cluster_848141 V1256117 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_692318 V1256119 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_711729 V1256120 SP_0498 map00511 G endo-beta-N-acetylglucosaminidase COG4724 Cluster_692319 V1256121 YQEV J MiaB-like tRNA modifying enzyme COG0621 Cluster_692320 V1256122 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_692321 V1256123 MGTE P magnesium transporter COG2239 Cluster_692323 V1256125 METF map00670,map00720,map01100,map01120 E Methylenetetrahydrofolate reductase COG0685 Cluster_692324 V1256126 PARB K parb-like partition protein COG1475 Cluster_766382 V1256129 RPLC map03010 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 Cluster_702386 V1256131 S atpase, aaa COG1373 Cluster_702387 V1256132 BMUL_5920 S Rhomboid family COG0705 Cluster_708573 V1256134 YTBE map00051,map00363,map00591,map00625,map00650,map01100,map01120 C reductase COG0656 Cluster_708574 V1256137 S NA 0Y8K6 Cluster_728323 V1256141 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_725040 V1256144 SERP0565 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_728324 V1256146 M NA 0ZY8Y Cluster_734845 V1256147 S NA 0YC4S Cluster_738182 V1256148 S NA 11R9W Cluster_744893 V1256151 S NA 1837C@proNOG Cluster_755131 V1256152 SDHB map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020 C succinate dehydrogenase COG0479 Cluster_758652 V1256153 S NA 0YH2T Cluster_175357 V1256154 LIN2410 V Inherit from COG: type I restriction-modification system COG0286 Cluster_48767 V1256155 STHIM L DNA methylase COG2189 Cluster_275102 V1256156 map00051,map00520,map01100,map02060 G pts system COG3716 Cluster_3069 V1256157 S Transglycosylase SLT domain COG5283 Cluster_330530 V1256158 S tail component COG4722 Cluster_13496 V1256159 M Phage minor structural protein COG4926 Cluster_8116 V1256161 S inulin fructotransferase 0XRZB Cluster_176154 V1256164 LYC M glycoside hydrolase, family 25 11T0J Cluster_777507 V1256168 S Pfam:DUF2825 17MFU@proNOG Cluster_166168 V1256169 HSDS V Restriction modification system DNA specificity COG0732 Cluster_41223 V1256170 L ATP-dependent endonuclease of the OLD COG3593 Cluster_1547 V1256173 S NA 11NI8 Cluster_64289 V1256180 S Bacteriophage peptidoglycan hydrolase 0ZNE8 Cluster_238634 V1256181 YUFN S basic membrane COG1744 Cluster_303700 V1256184 S surface protein 11NE4 Cluster_683429 V1256185 S Inherit from COG: ATPase (AAA COG1373 Cluster_52367 V1256186 S Phage prohead protease, HK97 family COG3740 Cluster_13919 V1256190 S NA 11NI8 Cluster_64577 V1256192 NPLT map00500,map01100,map04973 G alpha amylase, catalytic region COG0366 Cluster_38318 V1256193 BCGIA V Type II restriction modification enzyme methyltransferase COG0286 Cluster_139012 V1256194 V restriction enzyme 0ZWSK Cluster_419790 V1256195 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_489728 V1256197 G Major Facilitator COG0477 Cluster_394829 V1256198 HSDA V DNA specificity domain protein COG0732 Cluster_178651 V1256199 MSMK map02010 G ABC transporter, ATP-binding protein COG3839 Cluster_781284 V1256201 GLVC map00010,map02060 G PTS System COG1264 Cluster_54755 V1256203 POXB map00620,map01100 E acetolactate synthase COG0028 Cluster_649134 V1256209 EMRE P multidrug resistance protein COG2076 Cluster_389474 V1256211 AROD map00400,map01100,map01110,map01230 E Type I DHQase COG0710 Cluster_824882 V1256215 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_230124 V1256216 S NA 121IM Cluster_766383 V1256217 YJDF S NA 11P5R Cluster_83805 V1256218 LMRB P Drug resistance transporter EmrB QacA 0XNN3 Cluster_80589 V1256220 S ABC transporter, ATP-binding protein COG0488 Cluster_126109 V1256223 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_107643 V1256234 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_254028 V1256237 map00230,map00240,map01100,map03030,map03430,map03440 L EXOIII COG2176 Cluster_206157 V1256242 LDCA V peptidase U61 LD-carboxypeptidase A COG1619 Cluster_447078 V1256248 PGPA map00564,map01100 I phosphatidylglycerophosphatase a COG1267 Cluster_313780 V1256250 S NA 11GVV Cluster_728325 V1256256 APBE H thiamine biosynthesis lipoprotein COG1477 Cluster_310765 V1256257 SP_1730 S Membrane COG3610 Cluster_357143 V1256265 S Filamentation induced by cAMP protein fic 11MJJ Cluster_443036 V1256267 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_715115 V1256268 YKOD map02010 P ABC transporter COG1122 Cluster_534570 V1256270 LEXA K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) COG1974 Cluster_360465 V1256271 SCRA map00500,map02060 G pts system COG2190 Cluster_290014 V1256272 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_629276 V1256273 C uridylyltransferase COG1085 Cluster_665762 V1256277 S NA 0ZHU9 Cluster_378895 V1256280 GLNP map02010 E amino acid AbC transporter COG0834 Cluster_149599 V1256283 E, G, P Major Facilitator Superfamily COG0477 Cluster_261700 V1256284 RODA map04112 D cell division protein COG0772 Cluster_288733 V1256285 C NADH flavin oxidoreductase NADH oxidase COG1902 Cluster_502418 V1256288 TERC P membrane protein, TerC COG0861 Cluster_169480 V1256289 PIPD E Dipeptidase COG4690 Cluster_189038 V1256293 SACB map00500,map01100,map02020 G levansucrase EC 2.4.1.10 0XR0E Cluster_805285 V1256294 LDB1079 L integrase family COG0582 Cluster_557841 V1256295 ASNA map00250,map00460,map00910,map01100,map01110,map01230 E asparagine synthetase A COG2502 Cluster_711734 V1256296 YFGQ P Cation-transporting atpase COG0474 Cluster_614379 V1256297 S NA 0ZHU9 Cluster_236120 V1256323 S surface protein 11NE4 Cluster_352115 V1256328 S integral membrane protein 11QKN Cluster_692325 V1256332 SOJ D Chromosome Partitioning Protein COG1192 Cluster_370373 V1256333 S Hydrolase COG1073 Cluster_252777 V1256334 PHND map02010 P phosphonate ABC transporter, periplasmic phosphonate-binding protein COG3221 Cluster_217357 V1256336 RNJB map03018 O Metallo-Beta-Lactamase COG0595 Cluster_218494 V1256337 PBP1A map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_770107 V1256338 S NA 0ZHU9 Cluster_233727 V1256346 S NA 11V0R Cluster_252778 V1256354 GG9_0942 L transposase COG2801 Cluster_692326 V1256359 YQEK map00760,map01100 H Metal Dependent Phosphohydrolase COG1713 Cluster_721675 V1256360 YLBM S UPF0348 protein COG1323 Cluster_715117 V1256368 M Inherit from NOG: Cell Wall 1248X Cluster_702389 V1256370 S NA 0ZHU9 Cluster_272415 V1256384 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_888216 V1256387 FABG map00061,map00780,map01040,map01100 I reductase 0XNW1 Cluster_281736 V1256394 S Membrane COG4485 Cluster_277735 V1256398 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins COG0706 Cluster_292680 V1256409 PLSX map00561,map00564,map01100 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) COG0416 Cluster_298207 V1256412 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 Cluster_319951 V1256413 PEPDA E Dipeptidase COG4690 Cluster_884290 V1256414 S NA 0ZHU9 Cluster_445028 V1256415 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_306593 V1256419 BL02952 S Membrane COG1434 Cluster_482761 V1256420 YNBB map00260,map00270,map00450,map01100,map01230 P aluminum resistance protein COG4100 Cluster_766386 V1256429 ATPE map00190,map00195,map01100 C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) COG0636 Cluster_405451 V1256444 C nitroreductase COG0778 Cluster_375339 V1256445 YGJR map00051,map00363,map00591,map00625,map00650,map01100,map01120 G oxidoreductase COG0673 Cluster_748244 V1256452 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_534571 V1256454 GLTP C proton sodium-glutamate symport protein COG1301 Cluster_734848 V1256461 SP_0145 G Major Facilitator COG0477 Cluster_573366 V1256463 SCRR K Sucrose operon repressor COG1609 Cluster_335093 V1256464 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_699341 V1256465 O Pentapeptide repeat protein COG1357 Cluster_813313 V1256466 VICK map02020 T Histidine kinase 0XNMH Cluster_425248 V1256468 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_439051 V1256470 CELB map02060 G iic component COG1455 Cluster_813314 V1256476 RPSI map03010 J 30S ribosomal protein S9 COG0103 Cluster_342566 V1256477 PRMA J Methylates ribosomal protein L11 (By similarity) COG2264 Cluster_382397 V1256486 G, M Nad-dependent epimerase dehydratase COG0702 Cluster_487388 V1256490 S NA 0ZHU9 Cluster_353773 V1256496 INLJ map05150 M Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps 1215X Cluster_362039 V1256501 YLMH J s4 domain protein COG2302 Cluster_540251 V1256507 GUAD map00230,map01100 F Guanine deaminase COG0402 Cluster_721676 V1256513 THYA map00240,map00670,map01100 F Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) COG0207 Cluster_637163 V1256518 S Putative amino acid metabolism 122BZ Cluster_563879 V1256525 S NA 0XRGD Cluster_482762 V1256528 ORF4 S domain protein COG3402 Cluster_512583 V1256531 SP_1492 S cell wall surface anchor family protein 0YURI Cluster_543179 V1256541 CDD map00240,map00983,map01100,map05219 F cytidine deaminase COG0295 Cluster_731617 V1256543 S NA 0ZFWW Cluster_618135 V1256559 L type iii restriction protein res subunit COG3886 Cluster_418007 V1256570 THID map00730,map01100 H phosphomethylpyrimidine kinase COG0351 Cluster_398338 V1256571 GAT map00230,map00983,map01100 F Glutamine amido-transferase COG0518 Cluster_398339 V1256573 ADDA L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation COG1074 Cluster_401847 V1256580 PHOP map02020 T Transcriptional regulatory protein, C terminal 11FPD Cluster_403638 V1256589 TOPB L Dna topoisomerase COG0550 Cluster_405452 V1256591 S NA 11NI8 Cluster_405453 V1256593 RBSK map00030 G ribokinase COG0524 Cluster_715118 V1256598 S NA 0ZHU9 Cluster_859731 V1256599 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_570143 V1256603 ADH map00010,map00051,map00071,map00350,map00363,map00591,map00625,map00626,map00650,map00830,map00980,map00982,map01100,map01110,map01120 C alcohol dehydrogenase COG1063 Cluster_711735 V1256608 S NA 17D58@proNOG Cluster_416201 V1256619 GLVC map00010,map02060 G PTS System COG1264 Cluster_828673 V1256622 TRMD map00900,map01100,map01110 J Specifically methylates guanosine-37 in various tRNAs (By similarity) COG0336 Cluster_427174 V1256632 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_781290 V1256646 S NA 0ZHU9 Cluster_433052 V1256651 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 Cluster_734849 V1256653 G Major Facilitator COG0477 Cluster_824884 V1256658 RNJB map03018 O Metallo-Beta-Lactamase COG0595 Cluster_437017 V1256660 map02010 V ABC transporter COG1132 Cluster_905094 V1256682 MACB V (ABC) transporter COG1136 Cluster_921650 V1256688 G Major Facilitator 0XPHU Cluster_456967 V1256692 PBP1A map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_482763 V1256695 FTSW map04112 D cell division protein COG0772 Cluster_453005 V1256696 DPNII V Type II restriction 0YTH4 Cluster_773794 V1256699 PETB map00190,map00195,map00910,map01100,map02020,map04260,map05010,map05012,map05016 C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) COG1290 Cluster_455026 V1256705 S NA 11NI8 Cluster_458954 V1256711 RLMB map00340,map00350,map00624,map01120 J RNA methyltransferase TrmH family group 3 COG0566 Cluster_463127 V1256727 LSA S (ABC) transporter COG0488 Cluster_467307 V1256730 S NA 124N5 Cluster_467308 V1256733 S NA 0XYFZ Cluster_469417 V1256735 YFGQ P Cation-transporting atpase COG0474 Cluster_471582 V1256742 MPTP_1202 S Lysm domain protein 11U6T Cluster_512584 V1256744 YUTD S transcriptional regulator COG4470 Cluster_478037 V1256749 G Major Facilitator 0ZXAG Cluster_475849 V1256752 STET E amino acid COG0531 Cluster_781293 V1256753 S NA 0ZHU9 Cluster_475850 V1256754 RNC map03008,map05205 K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) COG0571 Cluster_781294 V1256755 RLUD2 J pseudouridine synthase COG0564 Cluster_478038 V1256761 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_480442 V1256764 LCTP C L-lactate COG1620 Cluster_487389 V1256780 YFLS P transporter COG0471 Cluster_738186 V1256786 YYAT map00350,map00362,map00627,map00642,map00903,map01120 Q acetyltransferase 121PI Cluster_586145 V1256791 XERS L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) COG0582 Cluster_793171 V1256800 NPDA map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_499882 V1256807 F permease COG2233 Cluster_499883 V1256808 NAGD map00627,map01120 G had-superfamily hydrolase, subfamily iia COG0647 Cluster_725042 V1256817 MUTT2 L Nudix family COG0494 Cluster_504825 V1256818 CELB map00052,map01100,map02060 G iic component COG1455 Cluster_570144 V1256831 SP_0145 G Major Facilitator COG0477 Cluster_793173 V1256835 APT map00230,map01100 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) COG0503 Cluster_510014 V1256837 RPOD map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_560892 V1256838 MLTD M Lytic Murein transglycosylase COG1388 Cluster_832438 V1256850 S NA 11U0C Cluster_576588 V1256853 VICR map02020 T response regulator COG0745 Cluster_523281 V1256863 COAA map00770,map01100 H pantothenic acid kinase COG1072 Cluster_526186 V1256874 GLYA map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01230 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) COG0112 Cluster_526187 V1256875 FBPA K Fibronectin-binding protein COG1293 Cluster_546114 V1256917 ARLS T Histidine kinase COG0642 Cluster_563880 V1256926 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_579715 V1256928 YNBB map00260,map00270,map00450,map01100,map01230 P aluminum resistance protein COG4100 Cluster_549150 V1256931 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_570146 V1256945 HSLO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) COG1281 Cluster_554924 V1256947 PHNE map02010 P phosphonate abc transporter COG3639 Cluster_560893 V1256954 OPPB E, P Oligopeptide ABC transporter, permease protein AppB COG0601 Cluster_560894 V1256959 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_560895 V1256962 S Uncharacterized conserved protein (DUF2075) COG3410 Cluster_563881 V1256963 PTSG map00010,map00500,map00520,map02060 G PTS System COG2190 Cluster_645024 V1256965 PACL P cation-transporting atpase COG0474 Cluster_567071 V1256969 MEPA V Mate efflux family protein COG0534 Cluster_567072 V1256975 NAGA map00052,map00520,map01110 G GlcNAc 6-P deacetylase COG1820 Cluster_596299 V1256985 YPUA S secreted protein COG4086 Cluster_570148 V1256986 M Sulfatase COG1368 Cluster_573370 V1256990 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_579716 V1257004 S NA 0Y6BA Cluster_579717 V1257006 YBIR P transporter COG0471 Cluster_586146 V1257013 GALM map00010,map01110,map01120 G converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) COG2017 Cluster_586147 V1257014 ENC_19000 map00010 G glycoside hydrolase, family 1 COG2723 Cluster_586148 V1257021 YHAM S Metal Dependent Phosphohydrolase COG3481 Cluster_618138 V1257032 S NA 0ZHU9 Cluster_603396 V1257044 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_766390 V1257045 S NA 0ZHU9 Cluster_603397 V1257050 G Major Facilitator COG0477 Cluster_610671 V1257062 E Arginine ornithine antiporter COG0531 Cluster_610672 V1257067 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_728334 V1257069 THII map00730,map01100,map04122 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) COG0301 Cluster_614382 V1257072 SDAA map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase COG1760 Cluster_649135 V1257078 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_665764 V1257079 TYPA T gtp-binding protein typa COG1217 Cluster_766391 V1257097 SILP S secreted protein containing plastocyanin domain COG4633 Cluster_625565 V1257100 S surface protein 11NE4 Cluster_625566 V1257105 YFNA E amino acid COG0531 Cluster_625567 V1257108 PIP map00330 E Releases the N-terminal proline from various substrates (By similarity) 0ZVIC Cluster_625569 V1257112 PSTB2 map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_674432 V1257113 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_629281 V1257123 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_633120 V1257127 YTXK L Adenine-specific COG0827 Cluster_751678 V1257129 SUFC O feS assembly ATPase SufC COG0396 Cluster_645026 V1257150 PSTC map02010 P phosphate abc transporter COG0573 Cluster_649137 V1257164 YDAM map00051,map00561,map01100 M Glycosyl transferase, family 2 COG1215 Cluster_649139 V1257172 OATA I Acyl-transferase COG1835 Cluster_661549 V1257175 GABD1 map00250,map00350,map00650,map01100,map01120 C Aldehyde dehydrogenase COG1012 Cluster_653204 V1257177 GNTR K Transcriptional regulator COG2188 Cluster_773798 V1257191 K Tetr family transcriptional regulator COG1309 Cluster_734853 V1257213 S Replication initiator protein 0XR3Z Cluster_687862 V1257215 MSF G Major Facilitator COG0477 Cluster_692330 V1257216 K Transcriptional regulator 0Y1S3 Cluster_665767 V1257221 YJBF S SNARE-like domain protein COG0398 Cluster_670057 V1257226 SCRR K Transcriptional regulator, LacI family COG1609 Cluster_824888 V1257238 map00620,map04011 S glyoxalase bleomycin resistance protein dioxygenase 11YIZ Cluster_755135 V1257239 S NA 0Y2WH Cluster_674433 V1257242 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_674434 V1257244 S NA 0ZHU9 Cluster_678879 V1257246 RDGB map00230,map00240,map01100 F Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) COG0127 Cluster_715121 V1257255 PARE L DNA topoisomerase IV (Subunit B) COG0187 Cluster_734855 V1257267 ZWF map00030,map00480,map01100,map01110,map01120 G glucose-6-phosphate 1-dehydrogenase COG0364 Cluster_817068 V1257274 YAAA S S4 domain protein YaaA COG2501 Cluster_40867 V1257287 BCGIA V Type II restriction modification enzyme methyltransferase COG0286 Cluster_708577 V1257294 PETB map00190,map00195,map00910,map01100,map02020,map04260,map05010,map05012,map05016 C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) COG1290 Cluster_267018 V1257295 NUOL map00190,map00910,map01100 C subunit l COG1009 Cluster_373629 V1257296 NUOM map00190,map00910,map01100 C subunit m COG1008 Cluster_84724 V1257297 S c4-dicarboxylate anaerobic carrier COG1288 Cluster_844249 V1257298 RPMH map03010 J 50S ribosomal protein l34 COG0230 Cluster_104613 V1257299 GND map00030,map00480,map01100,map01110,map01120 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) COG0362 Cluster_737 V1257300 S surface protein 11NE4 Cluster_105816 V1257301 PEPC E aminopeptidase c COG3579 Cluster_211628 V1257302 S Myosin-Cross-Reactive Antigen COG4716 Cluster_687863 V1257305 S Major tail protein 0Y77V Cluster_303701 V1257306 S Protein of unknown function (DUF2785) 123P8 Cluster_467309 V1257307 S surface protein 11NE4 Cluster_26261 V1257308 XFP map00030,map00680,map00710,map01100,map01120 G Phosphoketolase COG3957 Cluster_150466 V1257309 MALE map02010 G (ABC) transporter COG2182 Cluster_77135 V1257310 DEXB map00052,map00500,map01100 G trehalose-6-phosphate hydrolase (EC 3.2.1.93) COG0366 Cluster_29791 V1257311 MAP2 map00500,map01100 G hydrolase family 65, central catalytic COG1554 Cluster_342567 V1257312 COBQ S Glutamine amidotransferase COG3442 Cluster_155306 V1257314 GALK map00052,map00520,map01100,map01110 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) COG0153 Cluster_433054 V1257315 RECX S Modulates RecA activity (By similarity) COG2137 Cluster_653208 V1257316 YLMH J s4 domain protein COG2302 Cluster_345785 V1257317 DIVIVA D Cell division protein DIVIVA COG3599 Cluster_175358 V1257318 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_750 V1257320 S NA 11NI8 Cluster_21004 V1257322 YLBB V abc transporter permease protein COG0577 Cluster_43709 V1257323 ASNB map00250,map00910,map01100,map01110,map01120 E asparagine synthetase COG0367 Cluster_307902 V1257324 GLVR K Transcriptional regulator COG1737 Cluster_324579 V1257325 SUFC O feS assembly ATPase SufC COG0396 Cluster_156973 V1257326 SUFS map00450,map00730,map01100 E Cysteine desulfurase COG0520 Cluster_107644 V1257328 GLCD map00630,map01100,map01110,map01120 C Glycolate oxidase subunit COG0277 Cluster_95214 V1257329 ARCD E Arginine ornithine antiporter COG0531 Cluster_99500 V1257331 BL03493 L phage plasmid primase, p4 family COG3378 Cluster_167700 V1257332 L Integrase COG0582 Cluster_375340 V1257333 C Nitroreductase COG0778 Cluster_260390 V1257334 map00360,map00362,map00650,map01100,map01120 C 3-hydroxybutyryl-CoA dehydrogenase COG1250 Cluster_43139 V1257335 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_3291 V1257336 S NA 11NI8 Cluster_52142 V1257338 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_42221 V1257339 PTSG map00010,map00500,map00520,map02060 G PTS System COG2190 Cluster_326076 V1257342 S NA 0XNUC Cluster_128913 V1257347 S NA 0XRGD Cluster_48963 V1257348 BGLF map00010,map00500,map00520,map02060 G pts system COG2190 Cluster_190761 V1257349 S Uncharacterized conserved protein (DUF2075) COG3410 Cluster_347378 V1257350 L DNA methylase n-4 n-6 domain protein COG0863 Cluster_180350 V1257351 YJHA S Endonuclease Exonuclease phosphatase 0XNVA Cluster_138257 V1257352 YNBB map00260,map00270,map00450,map01100,map01230 P aluminum resistance protein COG4100 Cluster_405454 V1257353 YLFI S integral membrane protein COG4478 Cluster_296820 V1257354 SP_2113 S membrAne COG1284 Cluster_90433 V1257355 YJEM E Inner membrane transporter yjeM 0XRYB Cluster_275103 V1257356 YVGN C reductase COG0656 Cluster_147307 V1257358 LDTA S ErfK YbiS YcfS YnhG COG1376 Cluster_251555 V1257360 G, K ROK family COG1940 Cluster_273746 V1257361 K Transcriptional Regulator AraC Family COG2207 Cluster_596300 V1257362 SILP S secreted protein containing plastocyanin domain COG4633 Cluster_199912 V1257363 LYTR K TRANSCRIPTIONal COG1316 Cluster_309321 V1257364 M Capsular exopolysaccharide family COG0489 Cluster_382398 V1257365 RFBP M exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase (EC 2.7.8.6) COG2148 Cluster_439052 V1257366 UPP map00240,map01100 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) COG0035 Cluster_212720 V1257367 C FMN-dependent alpha-hydroxy acid dehydrogenase COG1304 Cluster_657333 V1257368 YVGN C reductase COG0656 Cluster_259082 V1257369 MSMF map02010 P ABC transporter, permease COG1175 Cluster_319952 V1257370 MSMK map02010 G ABC transporter, ATP-binding protein COG3839 Cluster_520524 V1257372 MUTS2 map03430 L muts2 protein COG1193 Cluster_520525 V1257373 SPRL S SprT-like COG3091 Cluster_9601 V1257374 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_152064 V1257375 RPSA map00900,map01100,map01110,map03010 J 30S ribosomal protein S1 COG0539 Cluster_88129 V1257378 map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020 C fumarate reductase succinate dehydrogenase flavoprotein domain protein COG1053 Cluster_380618 V1257380 I PAP2 Family COG0671 Cluster_69270 V1257381 MALL map00052,map00500,map01100 G Oligo-1,6-glucosidase COG0366 Cluster_245181 V1257383 MRAY map00550,map01100 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) COG0472 Cluster_212721 V1257384 MURD map00471,map00550,map01100 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COG0771 Cluster_16444 V1257385 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_198914 V1257386 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_144984 V1257387 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_728337 V1257388 V Abi-like protein COG4823 Cluster_211629 V1257392 CCPA K catabolite control protein a COG1609 Cluster_128914 V1257394 P Major Facilitator superfamily COG0477 Cluster_439053 V1257395 NTH map03410 L endonuclease III COG0177 Cluster_789398 V1257396 K Transcriptional regulator 120E9 Cluster_97364 V1257397 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_83806 V1257398 S NA 0XPYR Cluster_27782 V1257399 DNAQ map03022,map03420 L helicase COG1199 Cluster_25903 V1257402 PEPX E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) 0XPUZ Cluster_11502 V1257403 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_385940 V1257405 O PPIases accelerate the folding of proteins (By similarity) COG0652 Cluster_144235 V1257409 SBND G Major Facilitator 0ZVCH Cluster_93304 V1257414 BCR P drug resistance transporter, Bcr CflA 16SB6@proNOG Cluster_152065 V1257415 NAGA map00520,map01110 G GlcNAc 6-P deacetylase COG1820 Cluster_97365 V1257422 SACP map00010,map00500,map00520,map02060 G Pts system COG1621 Cluster_97366 V1257426 CELA map00010 G 6-phospho-beta-glucosidase (EC 3.2.1.86) COG2723 Cluster_51331 V1257428 PGM map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_246510 V1257429 LDH map00010,map00270,map00620,map00640,map01100,map01110,map01120 C L-lactate dehydrogenase COG0039 Cluster_172905 V1257430 MDH C malate L-lactate dehydrogenase COG2055 Cluster_83403 V1257431 CITF map00020,map01110,map02020 C citrate lyase, alpha COG3051 Cluster_185579 V1257432 LMRD V ABC transporter COG1132 Cluster_715122 V1257435 S Protein of unknown function (DUF1304) 0XV9E Cluster_194438 V1257439 G hydrolase, family 76 COG4833 Cluster_151231 V1257441 AMTB P Ammonium transporter 16PRG@proNOG Cluster_92822 V1257448 YCLK T Histidine kinase 0XNMH Cluster_96306 V1257449 YFLS P transporter COG0471 Cluster_122844 V1257452 E amino acid COG0531 Cluster_347379 V1257453 YBHL S Membrane COG0670 Cluster_517971 V1257456 map00052,map00500,map01100 G Alpha-glucosidase COG1501 Cluster_194439 V1257457 LYSP E permease COG0833 Cluster_126814 V1257460 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_95215 V1257461 S NA 0Y2NV Cluster_148841 V1257464 T Serine threonine protein kinase with WD-40 repeats COG0515 Cluster_58045 V1257467 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_275104 V1257469 MALG map02010 P ABC transporter, permease COG3833 Cluster_85122 V1257471 CYSG map00860,map01100,map01110 H Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) COG1648 Cluster_127508 V1257473 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_144236 V1257475 G Major Facilitator 0XRAD Cluster_290016 V1257476 CITG map02020 H triphosphoribosyl-dephospho-CoA synthase COG1767 Cluster_298208 V1257480 K anti-repressor COG3645 Cluster_154473 V1257481 GALP map04113 G transporter 16TAE@proNOG Cluster_589439 V1257483 DHAM G Dihydroxyacetone kinase COG3412 Cluster_360466 V1257484 GSTA map00480,map00980,map00982,map05204 O Glutathione S-transferase 175JU@proNOG Cluster_277736 V1257485 BL05187 O Band 7 protein COG0330 Cluster_255235 V1257486 RFBA map00521,map00523,map01100,map01110 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) COG1209 Cluster_316884 V1257487 LACR K DeoRC COG1349 Cluster_473677 V1257496 YBBR S ybbr family COG4856 Cluster_255236 V1257498 map00310 Q dioxygenase COG2175 Cluster_67154 V1257501 S repeat-containing protein 0XP3K Cluster_347380 V1257502 map00230,map00240,map00760,map01100,map01110 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) COG0005 Cluster_257752 V1257503 K WD-40 repeat-containing protein COG1409 Cluster_543181 V1257506 V i restriction-modification system COG0732 Cluster_250337 V1257508 L Primosomal protein DnaI COG1484 Cluster_419791 V1257509 DNAB L replication initiation and membrane attachment protein COG3611 Cluster_129624 V1257515 SACB map00500,map01100,map02020 G levansucrase EC 2.4.1.10 0XR0E Cluster_172906 V1257518 YDCQ D ftsk SpoIIIE family protein COG1674 Cluster_54756 V1257520 OPPA E ABC transporter COG0747 Cluster_649140 V1257529 O PPIases accelerate the folding of proteins (By similarity) COG0652 Cluster_60661 V1257535 LYSP E permease COG0833 Cluster_72488 V1257540 RNY S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 Cluster_925627 V1257542 S NA 0ZHU9 Cluster_94706 V1257545 LDB1095 map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020 C Fumarate reduCtase COG1053 Cluster_62093 V1257546 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_125421 V1257547 S glutamate carboxypeptidase II 0XR2Z Cluster_207253 V1257549 E TGF-beta receptor type I II extracellular region COG3104 Cluster_64847 V1257550 map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G 6-phosphofructokinase COG0205 Cluster_95216 V1257551 YFNA E amino acid COG0531 Cluster_302253 V1257552 MURI map00230,map00240,map00471,map01100 M Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) COG0796 Cluster_64848 V1257560 O protease COG0265 Cluster_393013 V1257564 AROE map00400,map01100,map01110,map01230 E shikimate dehydrogenase COG0169 Cluster_485092 V1257570 PSUG map00240 Q Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) COG2313 Cluster_237317 V1257580 BL05139 map00564 C Glycerophosphoryl diester phosphodiesterase family COG0584 Cluster_528955 V1257585 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (alpha subunit) COG0587 Cluster_119143 V1257588 S pyridine nucleotide-disulfide oxidoreductase 11I5C Cluster_300877 V1257589 K transcriptional regulator 0ZMZA Cluster_387755 V1257603 GALP map04113 G transporter 16TAE@proNOG Cluster_92371 V1257606 SCLAV_4362 V ABC transporter transmembrane region COG1132 Cluster_185580 V1257607 S Replication initiator protein 0XR3Z Cluster_92824 V1257609 map00052,map00500,map01100 G Glycoside hydrolase family 31 COG1501 Cluster_275105 V1257611 METB map00260,map00270,map00450,map00920,map01100,map01110,map01230 E Cystathionine gamma-synthase COG0626 Cluster_268433 V1257616 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_122845 V1257619 E amino acid COG0531 Cluster_97895 V1257623 COPA P p-type ATPase COG2217 Cluster_445029 V1257624 S WD domain, G-beta repeat 0XP3K Cluster_407113 V1257625 MVAD map00900,map01100,map01110 I diphosphomevalonate decarboxylase COG3407 Cluster_98976 V1257626 P drug resistance transporter, EmrB QacA subfamily 0XQZX Cluster_122169 V1257628 PGM map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_131909 V1257631 GATA map00970,map01100 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) COG0154 Cluster_357144 V1257634 HEXOKINASE map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map04066,map04910,map04930,map04973 G hexokinase COG5026 Cluster_678880 V1257639 S Polysaccharide Biosynthesis Protein 0XRK0 Cluster_494708 V1257640 S NA 0ZHU9 Cluster_114899 V1257650 L DNA helicase COG1112 Cluster_117009 V1257654 ACEA map00630,map01100,map01120 C Isocitrate lyase COG2224 Cluster_119144 V1257657 S repeat protein COG0457 Cluster_789400 V1257660 S NA 0ZHU9 Cluster_122170 V1257661 F, H cytosine purines, uracil, thiamine, allantoin permease COG1953 Cluster_407114 V1257668 S NA 0ZHU9 Cluster_674438 V1257674 PSUG map00240 Q Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) COG2313 Cluster_485093 V1257680 L Integrase 0ZS5X Cluster_540253 V1257681 CYCA E amino acid COG1113 Cluster_299491 V1257685 ACIN_0074 L Transposase COG3464 Cluster_135081 V1257687 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_138258 V1257689 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_315364 V1257695 map02010 S transporter, permease COG4587 Cluster_141283 V1257701 OTSA map00500,map01100 G alpha-alpha-trehalose-phosphate synthase COG1877 Cluster_205071 V1257703 G Cellulase (glycosyl hydrolase family 5) 0XQAP Cluster_142785 V1257706 HACA map00290,map00300,map00660,map01100,map01110,map01210,map01230 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) COG0065 Cluster_144237 V1257709 L helicase COG0553 Cluster_144238 V1257711 GALP G transporter 16TAE@proNOG Cluster_144985 V1257713 S LRR 0ZKNA Cluster_150467 V1257716 M Glycosyltransferase sugar-binding region containing DXD motif COG3774 Cluster_310766 V1257724 MORA C reductase COG0656 Cluster_165358 V1257728 YBDL map00300,map01100,map01120,map01230 E Aminotransferase class I and II COG0436 Cluster_246511 V1257729 XERC2 L Integrase COG0582 Cluster_152900 V1257733 CYSN map00230,map00450,map00920,map01100,map01120 P May be the GTPase, regulating ATP sulfurylase activity (By similarity) COG2895 Cluster_621785 V1257734 RPSN map03010 J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) COG0199 Cluster_552038 V1257737 DTD J Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) COG1490 Cluster_227791 V1257742 S NA 0YIYD Cluster_892352 V1257744 DEF2 J peptide deformylase COG0242 Cluster_157838 V1257745 map00130,map01100,map01110 H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) COG0043 Cluster_193506 V1257747 G Glycoside hydrolase family 76 COG4833 Cluster_832451 V1257751 CPO S hydrolase COG0596 Cluster_233728 V1257752 CITR K regulatoR COG2390 Cluster_528956 V1257753 MARR K Transcriptional regulator 0XUB6 Cluster_268434 V1257757 HFLC O SPFH domain, Band 7 family protein COG0330 Cluster_163710 V1257760 FAS map00061,map01100 I fatty acid synthase COG4982 Cluster_162899 V1257761 HELZ L helicase COG0553 Cluster_537465 V1257762 AHPC O alkyl hydroperoxide reductase thiol specific antioxidant Mal allergen COG0450 Cluster_360467 V1257766 B, K histone acetyltransferase COG1243 Cluster_183002 V1257768 PPNK map00760,map01100 G Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) COG0061 Cluster_230126 V1257770 GGT map00430,map00460,map00480,map00590,map01100 E Gamma-glutamyltranspeptidase (EC 2.3.2.2) COG0405 Cluster_165359 V1257771 T Serine Threonine protein kinase with WD40 repeats 0YMKP Cluster_487391 V1257773 map00600,map01100 I Fatty acid desaturase 16TIQ@proNOG Cluster_362040 V1257774 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_168550 V1257779 HRPA L ATP-dependent helicase COG1643 Cluster_251556 V1257784 map00361,map00362,map00364,map00623,map01100,map01120 Q catechol 1,2-dioxygenase COG3485 Cluster_173730 V1257788 YGDL H uba thif-type nad fad binding protein COG1179 Cluster_174549 V1257794 HRPA L ATP-dependent helicase COG1643 Cluster_797159 V1257798 S NA 0Z01C Cluster_528248 V1025603 S integrase family 0ZXAY Cluster_440540 V1025604 XPT map00230,map01100,map01110 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) COG0503 Cluster_602331 V1025605 PHR L deoxyribo-dipyrimidine photolyase COG0415 Cluster_428600 V1025607 D atpase involved in chromosome 11NFV Cluster_468899 V1025608 RV1324 O Thioredoxin COG3118 Cluster_617006 V1025613 MT2226 map00350,map00362,map00627,map00642,map00903,map01120 S Gcn5-related n-acetyltransferase COG0456 Cluster_733948 V1025615 S Domain of unknown function (DUF1858) 11Y6H Cluster_613284 V1025617 map00240,map01100 F Dihydroorotate dehydrogenase COG0167 Cluster_428601 V1025618 YBIR P transporter COG0471 Cluster_788410 V1025620 FAHA map00350,map01100,map01120 Q fumarylacetoacetate (faa) hydrolase COG0179 Cluster_635930 V1025621 MAIA map00350,map00480,map00643,map00980,map00982,map01100,map01120,map05204 Q maleylacetoacetate isomerase COG0625 Cluster_569264 V1025623 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_639994 V1025625 DPM1 map00510,map01100 M dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) 0XQRC Cluster_428602 V1025626 CZCA P heavy metal efflux pump, CzcA family COG3696 Cluster_428603 V1025627 HTRB map00540,map01100 M Lipid A Biosynthesis COG1560 Cluster_430582 V1025630 MUTS2 map03430 L muts2 protein COG1193 Cluster_430583 V1025631 SCLAV_2230 V ABC, transporter COG0577 Cluster_664545 V1025632 FECD map02010 P transporter permease COG0609 Cluster_566166 V1025638 S NA 17T72@proNOG Cluster_519834 V1025642 L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) COG0582 Cluster_740701 V1025646 CIOA map00190,map01100,map02020 C (Ubiquinol oxidase) subunit I COG1271 Cluster_511901 V1025649 LEGAS_1040 L transposase COG2963 Cluster_430584 V1025652 WBPC I Acyl-transferase COG1835 Cluster_707789 V1025653 YCCF S Membrane COG3304 Cluster_858506 V1025657 map00300,map01100,map01210,map01230 K GntR family transcriptional regulator COG1167 Cluster_468900 V1025658 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_432582 V1025659 UHPT map02020 G transporter COG2271 Cluster_560075 V1025664 MTSC map02010,map02020 P ABC transporter COG1108 Cluster_430585 V1025665 M Inherit from NOG: Polymorphic outer membrane protein 11KKP Cluster_454566 V1025666 K LysR family Transcriptional regulator 16SRU@proNOG Cluster_858507 V1025669 S integral membrane protein COG5477 Cluster_733949 V1025670 G extracellular solute-binding protein COG1653 Cluster_432583 V1025672 AFTB S Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids 0YKVT Cluster_432584 V1025673 UVRA2 map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_432585 V1025674 S domain protein 17S45@proNOG Cluster_545256 V1025679 M outer membrane chaperone Skp (OmpH) 11PTW Cluster_501750 V1025680 GATB map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 Cluster_432586 V1025681 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_754184 V1025682 S NA 12C56 Cluster_572459 V1025689 K transcriptional repressor, copy family 17JRQ@proNOG Cluster_530998 V1025692 CYSK map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_434469 V1025694 M NA 0YHI1 Cluster_714258 V1025695 V Mate efflux family protein COG0534 Cluster_432587 V1025696 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_434470 V1025699 SGR_15T L helicase COG0210 Cluster_434471 V1025702 AARI_35290 L integrase catalytic COG2801 Cluster_442560 V1025703 S Protein of unknown function (DUF1524) COG1479 Cluster_843186 V1025705 FDHD C Necessary for formate dehydrogenase activity (By similarity) COG1526 Cluster_434472 V1025706 S NA 11RZ5 Cluster_446582 V1025709 BMUL_0568 S Import inner membrane translocase subunit TIM44 COG4395 Cluster_522535 V1025716 YEHB map05133 M outer membrane usher protein COG3188 Cluster_875073 V1025717 S NA 12B1E Cluster_660332 V1025718 NADV map00760,map01100 H phosphoribosyltransferase COG1488 Cluster_436510 V1025722 PFOR G Perfringolysin O regulator protein COG1299 Cluster_631973 V1025724 S Alpha Beta Hydrolase Fold protein COG0596 Cluster_717517 V1025726 S HIRAN domain protein 0XVUM Cluster_870939 V1025728 FADE map00071,map00280,map00281,map00650,map00930,map01100,map01110,map01120 I acyl-CoA dehydrogenase COG1960 Cluster_562979 V1025729 map00071,map00360,map00362,map00650,map00720,map01100,map01120 I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain COG1250 Cluster_434473 V1025730 PURL map00230,map01100,map01110 F Formylglycinamide ribotide synthetase COG0047 Cluster_436511 V1025732 AGNC map00531,map01100,map04142 S Alpha-N-acetylglucosaminidase 0XNMK Cluster_501751 V1025735 BIOA map00780,map01100 H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) COG0161 Cluster_769185 V1025736 YFIR S NA 17EA1@proNOG Cluster_847182 V1025737 RV1847 Q thioesterase Superfamily protein COG2050 Cluster_436512 V1025738 CYNX G Major Facilitator Superfamily COG2807 Cluster_536679 V1025741 BDI_0123 S NA 11NUB Cluster_733950 V1025748 RFBB map00521,map00523,map01055,map01100,map01110 M dTDP-glucose 4,6-dehydratase COG1088 Cluster_477464 V1025749 GCDH map00071,map00281,map00310,map00380,map01100,map01110 I Dehydrogenase COG1960 Cluster_436514 V1025750 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_656189 V1025752 YTFH K Transcriptional regulator COG1733 Cluster_628207 V1025756 RPLV map03010 J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) COG0091 Cluster_519835 V1025757 P Binding-protein-dependent transport systems, inner membrane component COG0601 Cluster_436515 V1025758 PEPI map00330 E Releases the N-terminal proline from various substrates (By similarity) COG0596 Cluster_769186 V1025759 CAPA M biosynthesis protein COG3944 Cluster_668882 V1025760 CAPB M Capsular exopolysaccharide family COG0489 Cluster_436516 V1025762 M Export protein 11PCV Cluster_438557 V1025763 CITA G metabolite H symporter, major facilitator superfamily 16QT5@proNOG Cluster_438558 V1025766 CRDA T two component, sigma54 specific, transcriptional regulator, Fis family COG2204 Cluster_517258 V1025767 TIPA K Transcriptional regulator COG0789 Cluster_473131 V1025769 KPTA J Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity) COG1859 Cluster_438559 V1025770 YNJI S inner membrane protein ynji 12A1H Cluster_438560 V1025771 MMPL3 H MMPL domain protein COG2409 Cluster_436517 V1025773 TRAG2 S conjugation system ATPase, TraG family 0XSHU Cluster_737219 V1025778 DACI_2724 L integrase family 171EX@proNOG Cluster_438561 V1025783 J rrna methyltransferase COG0566 Cluster_660333 V1025785 V Type I Restriction 11KA4 Cluster_456492 V1025789 S tape measure domain protein 11PSY Cluster_438563 V1025790 S Uncharacterised protein family (UPF0104) 10F01 Cluster_504196 V1025791 FHAA T FHA Domain-Containing protein COG1716 Cluster_528249 V1025794 INSI L transposase COG2826 Cluster_440541 V1025795 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_780124 V1025797 S dedA family COG0586 Cluster_438564 V1025798 L UvrD REP helicase COG1074 Cluster_588494 V1025800 S metal-dependent hydrolase COG1451 Cluster_178652 V1257804 ARAB map00040,map01100 C ribulokinase COG1069 Cluster_183003 V1257809 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_181170 V1257813 E Aminotransferase, class I COG0436 Cluster_365361 V1257821 LYSP E permease COG0833 Cluster_183826 V1257824 G hydrolase family 65, central catalytic COG1554 Cluster_403639 V1257832 CHAC P Cation transport protein COG3703 Cluster_187339 V1257841 E solute symporter COG0591 Cluster_187340 V1257843 T Histidine kinase COG2770 Cluster_188199 V1257845 GALP G transporter 0XNQK Cluster_218495 V1257860 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_190762 V1257861 DPP map04974 E peptidase COG1506 Cluster_191682 V1257862 PEPN map00480,map01100 E Peptidase M1 membrane alanine aminopeptidase COG0308 Cluster_221996 V1257867 S glutamate carboxypeptidase II 0XR2Z Cluster_230127 V1257869 ILVC map00290,map00770,map01100,map01110,map01210,map01230 E Alpha-keto-beta-hydroxylacyl reductoisomerase COG0059 Cluster_728340 V1257895 ECFA1 map02010 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates COG1122 Cluster_451077 V1257896 DLD map00620,map00630,map00650,map01100,map01110,map01120 C d-lactate dehydrogenase COG0277 Cluster_205072 V1257903 HRPA L ATP-dependent helicase COG1643 Cluster_298210 V1257904 C l-carnitine dehydratase bile acid-inducible protein F COG1804 Cluster_543184 V1257910 map00400,map01100,map01110 E Prephenate dehydrogenase COG0287 Cluster_207254 V1257914 GALM map00010,map01110,map01120 G converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) COG2017 Cluster_809335 V1257915 CSAB map00051 M Polysaccharide pyruvyl transferase COG2327 Cluster_339595 V1257923 S LRR 0ZKNA Cluster_217359 V1257946 CYSN map00230,map00450,map00920,map01100,map01120 P May be the GTPase, regulating ATP sulfurylase activity (By similarity) COG2895 Cluster_246513 V1257947 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_219646 V1257953 FADD6 map00281,map01110 Q Amp-dependent synthetase and ligase COG0318 Cluster_309322 V1257966 YWDH map00010,map00040,map00053,map00071,map00280,map00281,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00626,map00640,map00903,map01100,map01110,map01120 C Aldehyde dehydrogenase COG1012 Cluster_224362 V1257968 RHLE2 map03018 L atp-dependent rna helicase COG0513 Cluster_692336 V1257972 KDUD map00040,map00061,map00780,map01040,map01100 S gluconate 5-dehydrogenase 0XNW1 Cluster_393014 V1257973 K WD-40 repeat-containing protein 0XP3K Cluster_233729 V1257976 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_230129 V1257982 ADHP map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120 C alcohol dehydrogenase COG1064 Cluster_230131 V1257986 LYSP E permease COG0833 Cluster_281739 V1257989 S NA 0XRN7 Cluster_291331 V1257992 PEPP E aminopeptidase COG0006 Cluster_231298 V1257993 ACX map00071,map00592,map01040,map01100,map03320,map04146 I acyl-CoA oxidase COG1960 Cluster_489730 V1257997 S Scp-like extracellular COG2340 Cluster_232473 V1257999 TYNA map00260,map00350,map00360,map00410,map00950,map00960,map01100,map01110 Q amine oxidase COG3733 Cluster_233730 V1258001 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_315365 V1258003 S Rna-binding protein COG0724 Cluster_257754 V1258026 E amino acid COG0531 Cluster_290017 V1258028 ENC_19000 map00010 G glycoside hydrolase, family 1 COG2723 Cluster_254030 V1258031 MT0451 map03050,map04141,map05134 O AAA ATPase COG0464 Cluster_242562 V1258033 YFDH map00051,map00510,map01100 M Glycosyl Transferase COG0463 Cluster_242563 V1258034 CUEO Q Multicopper oxidase COG2132 Cluster_245183 V1258045 map00520,map01110 G hydrolase family, 3 COG1472 Cluster_246514 V1258046 PYRB map00240,map00250,map01100 F aspartate transcarbamylase COG0540 Cluster_296822 V1258047 UBIA map00130,map01100,map01110 H Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) COG0382 Cluster_247770 V1258052 COABC map00770,map01100 H Phosphopantothenoylcysteine decarboxylase COG0452 Cluster_330531 V1258053 S Dehydrogenase 0Y8QQ Cluster_259083 V1258059 G class II Aldolase COG0235 Cluster_603398 V1258060 S 5'-phosphate oxidase COG3576 Cluster_319953 V1258072 LYSP E permease COG0833 Cluster_252779 V1258075 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_254031 V1258076 ATP2C1 P Atpase, p-type (Transporting), had superfamily, subfamily ic COG0474 Cluster_255237 V1258085 GND map00030,map00480,map01100,map01110,map01120 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) COG0362 Cluster_453007 V1258088 MSRA O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) COG0225 Cluster_256472 V1258089 P Atpase, p-type (Transporting), had superfamily, subfamily ic COG0474 Cluster_256473 V1258090 S pathogenesis 0XR1H Cluster_378898 V1258094 PDXY map00750,map01100 H functions in a salvage pathway. Uses pyridoxamine (By similarity) COG2240 Cluster_256475 V1258097 DCP E oligopeptidase A COG0339 Cluster_256476 V1258098 G transporter 0XNQK Cluster_256477 V1258100 PATATIN T K07001 NTE family protein COG1752 Cluster_257755 V1258102 GLNS map00970,map01100 J glutaminyL-tRNA synthetase COG0008 Cluster_259085 V1258106 T Serine threonine protein kinase with WD-40 repeats COG0515 Cluster_321434 V1258111 GLNQ map02010 E abc transporter atp-binding protein COG1126 Cluster_310768 V1258113 map00920,map01100,map01120 P 3'(2')5'-bisphosphate nucleotidase COG1218 Cluster_259086 V1258114 ILVD map00290,map00770,map01100,map01110,map01210,map01230 E Dihydroxy-acid dehydratase COG0129 Cluster_259087 V1258115 L Domain protein COG0507 Cluster_423440 V1258122 FAS map00061,map01100 I fatty acid synthase COG4982 Cluster_389476 V1258124 ESTB L Phospholipase Carboxylesterase COG0400 Cluster_473678 V1258126 S Lipase (EC 0XS3K Cluster_261703 V1258131 L dEAD DEAH box helicase COG1204 Cluster_309323 V1258135 AROG map00400,map01100,map01110,map01230 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) COG0722 Cluster_264378 V1258137 ADHB map00051,map00363,map00591,map00625,map00650,map01100,map01120 E Dehydrogenase COG1063 Cluster_280407 V1258139 Q Multicopper oxidase COG2132 Cluster_419792 V1258141 DUSB J Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_264379 V1258142 S NB-ARC domain 0XP3K Cluster_327634 V1258144 MT0451 map03050,map04141,map05134 O AAA ATPase COG0464 Cluster_269780 V1258166 COQ7 map00130,map01100,map01110 H Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity) COG2941 Cluster_271084 V1258171 FAS map00061,map00350,map00362,map00627,map00642,map00903,map01100,map01120 I synthase COG4982 Cluster_437019 V1258175 M UPF0103 Mediator of ErbB2-driven cell motility-containing protein COG2078 Cluster_288735 V1258176 COBB map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_467310 V1258179 map00052,map00500,map01100 G hydrolase, family 31 COG1501 Cluster_421582 V1258181 PEPP E aminopeptidase COG0006 Cluster_272421 V1258191 MOEB map00730,map01100,map04122 H uba thif-type nad fad binding protein COG0607 Cluster_333589 V1258196 XYLE G transporter 0XNQK Cluster_276432 V1258209 AROA map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate synthase COG0128 Cluster_277737 V1258212 NDVC map00500 G Beta (1-6) glucans synthase COG5309 Cluster_485095 V1258218 Q Methyltransferase COG0500 Cluster_280408 V1258224 GALP G transporter 16TAE@proNOG Cluster_279093 V1258225 DINB L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity) COG0389 Cluster_280409 V1258226 PDHA map00010,map00020,map00620,map00650,map01100,map01110,map01120,map04066 C Pyruvate dehydrogenase COG1071 Cluster_280411 V1258229 D ATP-binding protein COG0489 Cluster_373631 V1258235 YUED S short-chain dehydrogenase reductase 179P0@proNOG Cluster_554926 V1258237 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_313783 V1258241 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_284521 V1258253 O Triacylglycerol lipase 11H5Y Cluster_313784 V1258254 T serine threonine protein kinase COG0515 Cluster_285972 V1258260 NRDA map00230,map00240,map00480,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_285973 V1258261 LEUA map00290,map00620,map01100,map01110,map01210,map01230 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) COG0119 Cluster_292683 V1258269 LYSP E permease COG0833 Cluster_288736 V1258271 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_357145 V1258272 SHC-2 map00909,map01110 I Squalene--hopene cyclase COG1657 Cluster_290021 V1258277 CSHA map03018 L atp-dependent rna helicase COG0513 Cluster_563884 V1258283 RPLN map03010 J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) COG0093 Cluster_291334 V1258286 MT0451 map03050,map04141,map05134 O AAA ATPase COG0464 Cluster_431047 V1258288 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_291336 V1258289 S repeat-containing protein COG0457 Cluster_291337 V1258293 map00627,map00790,map01100,map01120,map02020 P alkaline phosphatase COG1785 Cluster_298213 V1258299 LYSP E permease COG0833 Cluster_294061 V1258300 PKNB T Serine Threonine protein kinase COG0515 Cluster_310769 V1258302 T Serine Threonine protein kinase with WD40 repeats 0YMKP Cluster_294062 V1258303 E solute symporter COG0591 Cluster_294064 V1258306 S WD domain, G-beta repeat 171WI@proNOG Cluster_295472 V1258307 GLYA map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01230 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) COG0112 Cluster_380619 V1258310 GYAR map00260,map00630,map01100,map01120 C D-isomer specific 2-hydroxyacid dehydrogenase COG1052 Cluster_437020 V1258311 BMUL_4019 map00340,map00361,map00363,map00623,map00624,map00626,map00627,map00903,map00930,map01100,map01120 P Monooxygenase COG2072 Cluster_305209 V1258312 CHIS T Histidine kinase 16PBK@proNOG Cluster_295473 V1258313 map02020 G Major Facilitator Superfamily 16PG8@proNOG Cluster_295474 V1258316 CMK15 map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120 C oxidoreductase COG0604 Cluster_296825 V1258320 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_316886 V1258321 TYRB map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aromatic amino acid aminotransferase COG1448 Cluster_298214 V1258322 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_451078 V1258325 G major facilitator superfamily MFS_1 0ZNSM Cluster_467311 V1258328 ACUC B, Q Histone deacetylase COG0123 Cluster_298218 V1258340 F cytosine purines uracil thiamine allantoin COG1457 Cluster_299493 V1258343 K RNA polymerase COG5108 Cluster_456969 V1258348 ICD map00020,map00480,map00720,map01100,map01110,map01120,map01210,map01230,map04146 C isocitrate dehydrogenase (NADP) COG0538 Cluster_300880 V1258352 S repeat-containing protein 0YBBK Cluster_300881 V1258353 MRP D ATP-binding protein COG0489 Cluster_625570 V1258356 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_303704 V1258362 S Lpxtg-motif cell wall anchor domain protein 0Y34J Cluster_305211 V1258377 SCLAV_1569 P drug resistance transporter, EmrB QacA subfamily 0XNN3 Cluster_307903 V1258389 VDH map00622,map00623,map00627,map01100,map01120,map01220 C Dehydrogenase COG1012 Cluster_312285 V1258392 V beta-lactamase COG1680 Cluster_309324 V1258397 FUMC map00020,map00720,map01100,map01110,map01120,map05200,map05211 C fumarate hydratase class II COG0114 Cluster_339596 V1258402 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_310771 V1258413 MDTK V Mate efflux family protein COG0534 Cluster_309327 V1258414 MDH map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120 C Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) COG0039 Cluster_310772 V1258415 RARA L recombination factor protein RarA COG2256 Cluster_449101 V1258416 T Histidine kinase COG2770 Cluster_570152 V1258417 S NA 0ZHU9 Cluster_310773 V1258418 HEME map00860,map01100,map01110 H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) COG0407 Cluster_312286 V1258419 TRMI J tRNA (Adenine-N1-)-methyltransferase COG2519 Cluster_463131 V1258422 PKNB T Serine Threonine protein kinase COG0515 Cluster_310774 V1258424 MDTK V Mate efflux family protein COG0534 Cluster_637166 V1258425 TRPE map00400,map01100,map01110,map01230 E synthase component I COG0147 Cluster_437021 V1258429 RBSK map00030 G ribokinase COG0524 Cluster_313788 V1258447 O Chaperonin Cpn60 TCP-1 COG0459 Cluster_316890 V1258464 MT0451 map03050,map04141,map05134 O AAA ATPase COG0464 Cluster_341054 V1258465 map00020,map00290,map01100,map01110,map01120,map01210,map01230 C Isocitrate dehydrogenase COG0473 Cluster_316891 V1258472 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_408886 V1258476 ACUC B, Q Histone deacetylase COG0123 Cluster_318474 V1258478 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_319954 V1258487 HTPG map04141,map04151,map04612,map04621,map04626,map04914,map04915,map05200,map05215 O Molecular chaperone. Has ATPase activity (By similarity) COG0326 Cluster_473680 V1258490 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_319956 V1258491 E permease COG0833 Cluster_502421 V1258493 RBPA S Rna-binding protein COG0724 Cluster_321435 V1258497 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_321436 V1258498 ICD map00020,map00290,map00480,map00720,map01100,map01110,map01120,map01210,map01230,map04146 E Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) COG0473 Cluster_504827 V1258504 BMNA map00511,map04142 G beta-mannosidase EC 3.2.1.25 COG3250 Cluster_322996 V1258507 OPLAH map00330,map00480,map01100 E 5-oxoprolinase (ATP-hydrolyzing) COG0146 Cluster_324580 V1258512 ETF map00910 C electron transfer flavoprotein-ubiquinone oxidoreductase COG0644 Cluster_384165 V1258513 map00380,map01100,map05143 E indoleamine 2,3-dioxygenase 0XQHE Cluster_327636 V1258525 PURL map00230,map01100,map01110 F Formylglycinamide ribotide synthetase COG0047 Cluster_327637 V1258526 PEPP E peptidase, M24 COG0006 Cluster_327638 V1258530 map00190 P Cation_ATPase_N COG0474 Cluster_329122 V1258536 SNF L snf2 family COG0553 Cluster_327640 V1258538 KMO map00380,map01100 H Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) COG0654 Cluster_540254 V1258542 G Alpha amylase, catalytic domain protein COG0366 Cluster_329124 V1258544 map03022,map03420 L type iii restriction protein res subunit COG1061 Cluster_692339 V1258552 FBP map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map04910 G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 COG0158 Cluster_482764 V1258554 map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020 C Flavocytochrome c COG1053 Cluster_400070 V1258560 CYSH map00920,map01100,map01120 P Reduction of activated sulfate into sulfite (By similarity) COG0175 Cluster_332085 V1258562 ADHB map00010,map00051,map00071,map00350,map00363,map00591,map00625,map00626,map00650,map00830,map00980,map00982,map01100,map01110,map01120 C Dehydrogenase COG1063 Cluster_342570 V1258563 L Helicase COG0507 Cluster_350611 V1258564 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_333590 V1258565 GCVP map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG1003 Cluster_332086 V1258566 PANE map00770,map01100,map01110 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) COG1893 Cluster_492215 V1258570 RPLQ map03010 J 50S ribosomal protein l17 COG0203 Cluster_335096 V1258573 CPN_0128 S biotin--protein ligase COG4285 Cluster_336631 V1258586 Q Ribosomal protein L11 methyltransferase (PrmA) 1DKIX@verNOG Cluster_336634 V1258593 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_338175 V1258594 GLNS map00970,map01100 J glutaminyL-tRNA synthetase COG0008 Cluster_338176 V1258597 S Family of unknown function (DUF500) COG2930 Cluster_338177 V1258598 CYSK2 map00270,map00920,map01100,map01120,map01230 E Cysteine synthase COG0031 Cluster_368678 V1258603 UDK map00240,map00710,map00983,map01100,map01120 F uridine kinase COG0572 Cluster_482766 V1258606 S NA 0ZHU9 Cluster_339603 V1258620 S WD domain, G-beta repeat 0XP3K Cluster_342571 V1258627 GYAR map00260,map00630,map00680,map01100,map01120,map01230 C Dehydrogenase COG1052 Cluster_342572 V1258629 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_534574 V1258634 ARGS map00970 J arginyL-tRNA synthetase COG0018 Cluster_344168 V1258638 OTSA map00500,map01100 G alpha-alpha-trehalose-phosphate synthase COG1877 Cluster_342574 V1258644 ETF map00910 C electron transfer flavoprotein-ubiquinone oxidoreductase COG0644 Cluster_445031 V1258645 METX map00270,map00920,map01100 E Homoserine O-trans-acetylase COG2021 Cluster_443038 V1258649 RIBE map00740,map01100 H riboflavin synthase, subunit alpha COG0307 Cluster_504828 V1258651 BGLS map00500,map01100 G Glycoside hydrolase family 16 COG2273 Cluster_344172 V1258653 T Serine Threonine protein kinase COG0515 Cluster_637167 V1258654 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_549154 V1258655 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_347385 V1258666 map00350,map00950,map01100,map01110 E Glutamate decarboxylase COG0076 Cluster_347386 V1258669 GALP G transporter 16TAE@proNOG Cluster_347389 V1258680 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_350612 V1258685 MT0451 map03050,map04141,map05134 O AAA ATPase COG0464 Cluster_350613 V1258686 LEUB map00290,map01100,map01110,map01210,map01230 E Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) COG0473 Cluster_348988 V1258688 NAHA map00051,map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 G ec 3.2.1.52 COG3525 Cluster_537468 V1258692 YJBQ S Secondary thiamine-phosphate synthase enzyme COG0432 Cluster_372014 V1258697 S Lipase (EC 0XS3K Cluster_350617 V1258700 MNTH P H( )-stimulated, divalent metal cation uptake system (By similarity) COG1914 Cluster_400071 V1258701 YFEH G Bile acid COG0385 Cluster_352120 V1258704 map00190 P Cation_ATPase_N COG0474 Cluster_367059 V1258708 T WD-40 repeat 16RQP@proNOG Cluster_355443 V1258717 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_416206 V1258719 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_353777 V1258720 map00051,map00230,map00240,map00760,map01100,map01110 M acid phosphatase 17H7K@proNOG Cluster_355446 V1258727 HRPA L ATP-dependent helicase COG1643 Cluster_405456 V1258730 SCLAV_1179 O Band 7 protein COG0330 Cluster_357148 V1258737 S repeat-containing protein 0XP3K Cluster_357153 V1258750 F cytosine purines uracil thiamine allantoin COG1457 Cluster_358804 V1258754 map00340,map01100,map01110,map01230 E Phosphoribosyl-AMP cyclohydrolase COG0139 Cluster_445032 V1258755 GST7 map00480,map00980,map00982,map05204 O Glutathione S-transferase COG0625 Cluster_360474 V1258774 ERIC P Chloride channel COG0038 Cluster_360475 V1258778 ARGG map00250,map00330,map01100,map01110,map01230 E Citrulline--aspartate ligase COG0137 Cluster_362044 V1258781 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_362045 V1258783 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_360477 V1258785 GATA map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120,map04723 Q K01426 amidase EC 3.5.1.4 COG0154 Cluster_362049 V1258790 YBIU S Protein of unknown function (DUF1479) 16SAU@proNOG Cluster_363621 V1258803 BIOB map00780,map01100 H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) COG0502 Cluster_362056 V1258811 map02020,map04115,map04210,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05168,map05200,map05210,map05222,map05416 T WD-40 repeat 16RQP@proNOG Cluster_888242 V1258816 S NA 17D58@proNOG Cluster_363623 V1258820 E amino acid COG0531 Cluster_410743 V1258827 map00052,map00500,map01100 G alpha-glucosidase EC 3.2.1.20 COG1501 Cluster_367060 V1258829 map00627,map00790,map01100,map01120,map02020 P alkaline phosphatase COG1785 Cluster_365367 V1258830 AROP E amino acid COG1113 Cluster_455029 V1258834 G Major Facilitator superfamily 16SJM@proNOG Cluster_429067 V1258838 MANC map00051,map00520,map00540,map01100,map01110 M Nucleotidyl transferase COG1208 Cluster_367062 V1258843 LYSP E permease COG0833 Cluster_368681 V1258846 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120 G phosphohexose isomerase COG0166 Cluster_445033 V1258850 map00730,map01100 L Nudix Hydrolase COG0494 Cluster_368683 V1258851 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_370379 V1258858 map00260 P rieske (2Fe-2S) COG4638 Cluster_653213 V1258862 map00920,map01100,map01120 P 3'(2')5'-bisphosphate nucleotidase COG1218 Cluster_372015 V1258865 MNME S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 Cluster_372019 V1258877 map00363,map01100,map01120 P Monooxygenase COG2072 Cluster_482768 V1258880 PQQL map00310,map00780,map01100 O Peptidase M16 domain protein COG0612 Cluster_373634 V1258883 CTAB map00190,map00860,map01100,map01110 O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) COG0109 Cluster_394830 V1258884 K WD-40 repeat-containing protein COG2319 Cluster_373635 V1258887 DLD2 map00620 C FAD linked oxidase domain protein COG0277 Cluster_425249 V1258889 map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map05204 C S-(hydroxymethyl)glutathione dehydrogenase class III alcohol dehydrogenase COG1062 Cluster_375345 V1258890 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_471586 V1258891 LYSP E permease COG0833 Cluster_375348 V1258898 PDHC map00010,map00020,map00620,map01100,map01110,map01120 C pyruvate dehydrogenase complex COG0508 Cluster_377113 V1258902 ARGJ map00330,map01100,map01110,map01210,map01230 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) COG1364 Cluster_905111 V1258903 S NA 0ZHU9 Cluster_377114 V1258905 V abc transporter atp-binding protein COG1131 Cluster_378900 V1258920 I Endonuclease Exonuclease phosphatase COG3568 Cluster_378904 V1258930 BGLB map00460,map00500,map00940,map01100,map01110 G glycoside hydrolase, family 3 domain protein COG1472 Cluster_378906 V1258935 L Snf2-related protein COG0553 Cluster_378907 V1258936 E amino acid COG0531 Cluster_380620 V1258939 HP1117 S Sel1 domain protein repeat-containing protein COG0790 Cluster_380621 V1258940 K WD-40 repeat-containing protein COG1409 Cluster_455030 V1258942 NANT G Major Facilitator Superfamily 16SE6@proNOG Cluster_380623 V1258943 DAPE map00300,map00310,map00330,map00780,map01100,map01110,map01120,map01210,map01230 E peptidase COG0624 Cluster_439056 V1258944 LYSP E permease COG0833 Cluster_380625 V1258947 O Chaperonin Cpn60 TCP-1 COG0459 Cluster_410744 V1258948 TRPB map00260,map00400,map01100,map01110,map01230 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) COG0133 Cluster_391206 V1258949 C alcohol dehydrogenase COG0604 Cluster_382402 V1258954 T Serine threonine protein kinase with WD-40 repeats COG0515 Cluster_382404 V1258962 MT0451 map03050,map04141,map05134 O AAA ATPase COG0464 Cluster_382405 V1258963 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_382406 V1258964 AROB map00400,map01100,map01110,map01230 E 3-dehydroquinate synthase COG0337 Cluster_384173 V1258978 PEPP E peptidase, M24 COG0006 Cluster_398344 V1258979 TREC map00052,map00500,map01100 G alpha amylase, catalytic region COG0366 Cluster_387759 V1258992 GLTD map00250,map00910,map01100,map01110,map01120,map01230 E glutamate synthase COG0493 Cluster_385950 V1258998 ACUC B, Q Histone deacetylase COG0123 Cluster_387761 V1259002 MT0451 map03050,map04141,map05134 O AAA ATPase COG0464 Cluster_427178 V1259023 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_389481 V1259029 O Tetratricopeptide tpr_2 repeat protein COG3914 Cluster_391210 V1259040 ARAT map04113 G transporter 0XNQK Cluster_391212 V1259043 RPE map00030,map00040,map00710,map01100,map01110,map01120,map01230 G ribulose-phosphate 3-epimerase COG0036 Cluster_480444 V1259060 G major facilitator superfamily MFS_1 1775Q@proNOG Cluster_400073 V1259063 METX map00270,map00920,map01100 E Homoserine O-trans-acetylase COG2021 Cluster_393022 V1259065 AROA map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate synthase COG0128 Cluster_534575 V1259069 S NA 0ZHU9 Cluster_429068 V1259081 PCKA map00010,map00020,map00620,map00710,map01100,map01110,map01120 C Phosphoenolpyruvate Carboxylase COG1866 Cluster_844257 V1259082 S NA 0ZHU9 Cluster_396615 V1259090 map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG1022 Cluster_398346 V1259102 S WD-40 repeat-containing protein 16RQP@proNOG Cluster_398347 V1259104 MDTK V Mate efflux family protein COG0534 Cluster_429069 V1259105 FOCA P Formate nitrite transporter COG2116 Cluster_398349 V1259111 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_614388 V1259116 S NA 0ZHU9 Cluster_755147 V1259119 S NA 0ZHU9 Cluster_401851 V1259129 FAS map00061,map00350,map00362,map00627,map00642,map00903,map01100,map01120 I synthase COG4982 Cluster_523285 V1259130 D, Z regulator of chromosome condensation, RCC1 COG5184 Cluster_401854 V1259141 K WD-40 repeat-containing protein 0XP3K Cluster_403642 V1259147 WCBT map00260,map00780,map01100 H 8-amino-7-oxononanoate synthase (EC 2.3.1.47) COG0156 Cluster_403646 V1259156 ACNA map00020,map00300,map00630,map00720,map01100,map01110,map01120,map01210,map01230 C Aconitate hydratase COG1048 Cluster_410746 V1259165 P transporter COG0471 Cluster_502423 V1259168 TAUD map00430 Q Taurine dioxygenase COG2175 Cluster_405465 V1259177 E solute symporter COG0591 Cluster_443041 V1259178 E Aminotransferase COG0436 Cluster_407117 V1259183 ARSB P arsenicaL-resistance protein COG0798 Cluster_434957 V1259184 YVGN C reductase COG0656 Cluster_510015 V1259191 S NA 0ZHU9 Cluster_407121 V1259192 SDHA map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map05134 C Succinate dehydrogenase (Flavoprotein subunit) COG1053 Cluster_407122 V1259193 map00260,map00440,map01100 E oxidoreductase COG2303 Cluster_407123 V1259195 map00720,map01120 S MaoC like domain protein COG3777 Cluster_407124 V1259196 SHC-2 map00909,map01110 I Squalene--hopene cyclase COG1657 Cluster_475853 V1259199 G class II Aldolase COG0235 Cluster_407125 V1259201 MT0451 map03050,map04141,map05134 O AAA ATPase COG0464 Cluster_408891 V1259204 LYSP E permease COG0833 Cluster_751683 V1259210 C Monooxygenase 0XNPZ Cluster_408896 V1259213 DLD map00620,map00630,map00650,map01100,map01110,map01120 C FAD linked oxidase domain protein COG0277 Cluster_410747 V1259217 PUCL map00230,map00232,map01100,map01120 Q Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) COG3648 Cluster_421586 V1259235 map00030,map00281,map01110,map01120 S Short-chain dehydrogenase reductase Sdr COG1028 Cluster_410751 V1259237 ARGB map00330,map01100,map01110,map01210,map01230 E nag kinase COG5630 Cluster_554928 V1259241 ADK map00230,map00240,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_451082 V1259249 RHLE2 map03018 L atp-dependent rna helicase COG0513 Cluster_414428 V1259255 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) COG0167 Cluster_414431 V1259263 map00500 G Cellulase (glycosyl hydrolase family 5) COG2730 Cluster_416209 V1259267 F thiJ pfpI COG0693 Cluster_416212 V1259271 SDHA map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map05134 C Succinate dehydrogenase (Flavoprotein subunit) COG1053 Cluster_416214 V1259273 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_489736 V1259278 O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_416216 V1259282 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_418014 V1259301 PURK map00230,map01100,map01110 F phosphoribosylaminoimidazole carboxylase atpase subunit COG0026 Cluster_419800 V1259310 TKTA map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_421592 V1259324 MT0156 map00051,map00362,map00363,map00591,map00625,map00626,map00650,map00903,map01100,map01110,map01120 I Short-chain dehydrogenase reductase Sdr COG1028 Cluster_421594 V1259329 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_423444 V1259343 UUP S Abc transporter, ATP-binding protein COG0488 Cluster_482769 V1259358 YCHF J gtp-binding protein COG0012 Cluster_683440 V1259363 YQJZ S Antibiotic biosynthesis monooxygenase COG2329 Cluster_463132 V1259365 NADE map00760,map01100 H Nad synthetase COG0388 Cluster_439057 V1259366 MTNP map00270,map01100 F Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) COG0005 Cluster_425252 V1259370 ACCC map00061,map00253,map00280,map00281,map00330,map00620,map00630,map00640,map00720,map00791,map01100,map01110,map01120 E urea carboxylase COG2049 Cluster_425253 V1259371 ACX map00071,map00592,map01040,map01100,map03320,map04146 I acyl-CoA oxidase COG1960 Cluster_492219 V1259373 T HPP family COG3448 Cluster_425255 V1259375 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_463133 V1259385 PEPP E aminopeptidase COG0006 Cluster_427182 V1259389 MT0451 map03050,map04141,map05134 O AAA ATPase COG0464 Cluster_427188 V1259396 S UPF0061 protein COG0397 Cluster_471588 V1259403 map00071,map00380,map00627,map01120 Q cytochrome P450 COG2124 Cluster_748256 V1259412 S 3-beta hydroxysteroid dehydrogenase/isomerase family 0ZY3G Cluster_429077 V1259417 map00380,map01100,map05143 E indoleamine 2,3-dioxygenase 0XQHE Cluster_429078 V1259418 NUCA map04210 F DNA RNA NON-specific endonuclease COG1864 Cluster_705508 V1259419 S NA 0ZHU9 Cluster_526192 V1259450 ROCF map00330,map00340,map01100,map01110,map01230,map05146 E arginase EC 3.5.3.1 COG0010 Cluster_433061 V1259451 LYSP E permease COG0833 Cluster_433062 V1259453 CFA map00130,map01100,map01110 M cyclopropane-fatty-acyl-phospholipid synthase COG2230 Cluster_517974 V1259455 FRCK H Fructose transport system kinase COG1072 Cluster_433064 V1259459 T GAF sensor hybrid histidine kinase COG2770 Cluster_678887 V1259460 ILVD map00290,map00770,map01100,map01110,map01210,map01230 E Dihydroxy-acid dehydratase COG0129 Cluster_434958 V1259462 CLPB O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity COG0542 Cluster_434959 V1259463 K WD-40 repeat-containing protein 0XP3K Cluster_434961 V1259476 E amino acid COG0531 Cluster_434962 V1259477 ALLB map00230,map00240,map01100,map01120 F Allantoinase (EC 3.5.2.5) COG0044 Cluster_433069 V1259484 map00680,map00982,map01120 P Monooxygenase COG2072 Cluster_434970 V1259491 E solute symporter COG0591 Cluster_557847 V1259492 MTNP map00270,map01100 F Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) COG0005 Cluster_434972 V1259500 S kelch repeat-containing protein 11ID1 Cluster_599808 V1259506 O Chaperonin Cpn60 TCP-1 COG0459 Cluster_437028 V1259510 PCBC S 2og-fe(ii) oxygenase COG3491 Cluster_437036 V1259521 GCVT map00260,map00670,map00910,map01100 E The glycine cleavage system catalyzes the degradation of glycine (By similarity) COG0404 Cluster_437039 V1259524 SLGD_00086 S Ser Thr phosphatase family protein COG1409 Cluster_499885 V1259526 FUMC map00020,map00720,map01100,map01110,map01120,map05200,map05211 C fumarate hydratase class II COG0114 Cluster_439061 V1259541 MT1789 V abc transporter atp-binding protein COG1131 Cluster_441045 V1259554 MALL map00052,map00500,map01100 G trehalose-6-phosphate hydrolase (EC 3.2.1.93) COG0366 Cluster_441047 V1259558 HRPA L ATP-dependent helicase COG1643 Cluster_441051 V1259563 GABD map00250,map00350,map00650,map01100,map01120 C Dehydrogenase COG1012 Cluster_441053 V1259565 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_441055 V1259573 SPEB_2 map00330,map01100 E agmatinase COG0010 Cluster_445039 V1259593 PTH J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) COG0193 Cluster_469422 V1259594 PDXT map00750 H Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) COG0311 Cluster_443052 V1259597 O Extracellular serine protease COG1404 Cluster_443054 V1259599 PGL map00030,map01100,map01110,map01120 G 6-phosphogluconolactonase (EC 3.1.1.31) COG0363 Cluster_449104 V1259605 MDLB map02010 V ABC transporter COG1132 Cluster_445043 V1259612 S NA 0ZHU9 Cluster_447085 V1259627 NAMA map00627,map00633,map01120 C flavin oxidoreductase COG1902 Cluster_445046 V1259628 T Serine threonine protein kinase with WD-40 repeats COG0515 Cluster_512588 V1259631 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_447088 V1259636 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_447090 V1259640 THIM map00730,map01100 H 4-methyl-5-beta-hydroxyethylthiazole kinase COG2145 Cluster_447091 V1259645 S Alcohol dehydrogenase zinc-binding domain protein COG2130 Cluster_447094 V1259650 MT1789 V abc transporter atp-binding protein COG1131 Cluster_520530 V1259653 map00430 Q Taurine dioxygenase COG2175 Cluster_520531 V1259660 DPP map04974 E peptidase COG1506 Cluster_449111 V1259661 RLME J Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) COG0293 Cluster_449113 V1259663 AMAB map00240,map00410,map00770,map00983,map01100 E amidohydrolase COG0624 Cluster_449118 V1259670 S Short-chain dehydrogenase reductase SDR 176BU@proNOG Cluster_461022 V1259674 THID map00730,map01100 H phosphomethylpyrimidine kinase COG0351 Cluster_451090 V1259692 ACCC map00061,map00253,map00620,map00640,map00720,map01100,map01110,map01120 I acetyl-CoA carboxylase biotin carboxylase COG0439 Cluster_451091 V1259694 S Collagen triple helix repeat 0YHFV Cluster_453013 V1259698 map00350,map00950,map01100,map01110 E Glutamate decarboxylase COG0076 Cluster_805304 V1259712 S NA 0ZHU9 Cluster_455034 V1259727 PRKC T serine threonine protein kinase COG2815 Cluster_469423 V1259729 O Chaperonin Cpn60 TCP-1 COG0459 Cluster_494718 V1259747 S repeat-containing protein 0XP3K Cluster_455042 V1259749 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_455043 V1259751 T serine threonine protein kinase COG0515 Cluster_469424 V1259756 S NA 0ZHU9 Cluster_467315 V1259768 SCLAV_3818 map00010,map00040,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00640,map00903,map01100,map01110,map01120 C Dehydrogenase COG1012 Cluster_456978 V1259789 map00600,map01100 I Fatty acid desaturase 1AIPY@sphNOG Cluster_456979 V1259793 PURC map00230,map01100,map01110 F SAICAR synthetase COG0152 Cluster_522463 V1002401 GATA map00970,map01100 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) COG0154 Cluster_660230 V1002402 NTPG map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG1436 Cluster_432533 V1002403 NTPC map00190,map00680,map01100 C ATP synthase subunit C COG1527 Cluster_274776 V1002404 map00511 G glycoside hydrolase family 38 COG0383 Cluster_274777 V1002405 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_342180 V1002406 S Membrane COG1811 Cluster_572379 V1002408 MALR map00473,map01100 K transcriptional regulator COG1609 Cluster_639899 V1002410 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_598777 V1002411 ACPS map00770 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) COG0736 Cluster_804207 V1002415 SP_2133 S NA COG4877 Cluster_765229 V1002416 SCLAV_3941 O Band 7 protein COG0330 Cluster_277427 V1002417 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_319625 V1002420 CINA H competence damage-inducible protein COG1546 Cluster_278806 V1002422 GDHA map00250,map00330,map00910,map01100 E Glutamate dehydrogenase COG0334 Cluster_772662 V1002423 PROV map02010 E ABC transporter COG1125 Cluster_426618 V1002424 ADHA map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120 C alcohol dehydrogenase COG1064 Cluster_668778 V1002425 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_591780 V1002426 SP_0666 S Inherit from COG: Alpha beta hydrolase COG0596 Cluster_496490 V1002427 PABB map00790 E synthase component I COG0147 Cluster_383710 V1002428 NT5E map00230,map00240,map00630,map00760,map01100,map01110 S Hydrolase COG0546 Cluster_282816 V1002430 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_282817 V1002431 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_303330 V1002432 S hydrolase COG0596 Cluster_284194 V1002433 YPJC S YitT family COG1284 Cluster_339260 V1002435 MANN map00051,map00520,map01100,map02060 G PTS system mannose fructose sorbose family transporter subunit IID COG3716 Cluster_730668 V1002436 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_499141 V1002437 Q Isochorismatase family 100QP Cluster_408416 V1002438 GUAC map00230 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) COG0516 Cluster_691086 V1002439 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_285608 V1002440 ELI_1307 M phage tail tape measure protein COG5283 Cluster_371595 V1002443 HMUO map00860,map04978 P Heme oxygenase COG5398 Cluster_288429 V1002447 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_691087 V1002449 YRKF P Rhodanese domain protein COG0607 Cluster_353407 V1002450 YVDE J Glutamine amidotransferase COG2071 Cluster_575629 V1002451 RPLQ map03010 J 50S ribosomal protein l17 COG0203 Cluster_289737 V1002452 T serine threonine protein kinase COG0515 Cluster_288431 V1002455 YCHF J gtp-binding protein COG0012 Cluster_528183 V1002457 SP_1783 L Nudix family COG0494 Cluster_772663 V1002458 K Gnat family COG0454 Cluster_289738 V1002459 NAMU_1182 L Transposase COG3328 Cluster_360047 V1002460 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_444507 V1002461 PLSX map00561,map00564,map01100 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) COG0416 Cluster_757680 V1002462 ACP I Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) COG0236 Cluster_290998 V1002464 UVRD map03420,map03430 L ATP-dependent DNA helicase pcra COG0210 Cluster_350184 V1002465 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_290999 V1002466 DLTB map05150 M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_291000 V1002467 LMRA map02010 V abc transporter COG1132 Cluster_319626 V1002471 G Major Facilitator superfamily 11GSZ Cluster_314986 V1002472 TEH_04440 map00052,map01100,map02060 G PTS system, galactitol-specific IIc component COG3775 Cluster_324185 V1002473 ARAA map00040,map01100 G Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) COG2160 Cluster_536615 V1002475 PTPA T Low molecular weight phosphotyrosine protein phosphatase COG0394 Cluster_545170 V1002477 RSEP map04112 M Membrane-associated zinc metalloprotease COG0750 Cluster_468843 V1002478 SP_0204 S acetyltransferase, (GNAT) family COG3981 Cluster_761256 V1002479 NRDG O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) COG0602 Cluster_293714 V1002482 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_392564 V1002483 YTPR J TRNA binding domain protein COG0073 Cluster_358407 V1002484 S (LipO)protein 0XQK7 Cluster_533713 V1002485 RIMI S ribosomal-protein-alanine acetyltransferase COG0456 Cluster_569190 V1002486 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_296531 V1002487 S NA 0YQ9H Cluster_296532 V1002488 G Binding-protein-dependent transport systems, inner membrane component COG4209 Cluster_301933 V1002489 METF map00670,map00720,map01100,map01120 E Methylenetetrahydrofolate reductase COG0685 Cluster_318080 V1002490 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_595176 V1002493 ESSB S Required for secretion of EsxA and EsxB COG4499 Cluster_569191 V1002494 RPSI map03010 J 30S ribosomal protein S9 COG0103 Cluster_380132 V1002495 GLDA map00561,map01100 C glycerol dehydrogenase COG0371 Cluster_299182 V1002496 PPK map00190,map03018 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) COG0855 Cluster_887098 V1002498 PEPX E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) 0XPUZ Cluster_530931 V1002499 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_796056 V1002500 SP_2064 S hydrolase COG0546 Cluster_412021 V1002501 NORM V Mate efflux family protein COG0534 Cluster_299183 V1002502 SP_0239 S UPF0210 protein COG2848 Cluster_371596 V1002503 GLPD map00564 C Glycerol-3-phosphate dehydrogenase COG0578 Cluster_319627 V1002504 OCAR_6878 map00281,map01110 C acyl-Coa dehydrogenase 0ZM68 Cluster_300517 V1002505 U Conjugal transfer protein 10082 Cluster_720721 V1002507 MVK map00900,map01100,map01110,map04146 I mevalonate kinase COG1577 Cluster_440483 V1002508 MVAD map00900,map01100,map01110 I diphosphomevalonate decarboxylase COG3407 Cluster_325695 V1002509 TCRX T regulator COG0745 Cluster_491542 V1002510 NTD map00240 F Nucleoside deoxyribosyltransferase COG3613 Cluster_316547 V1002511 O Band 7 protein COG0330 Cluster_368278 V1002515 ISPD map00900,map01100,map01110 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COG1211 Cluster_924501 V1002516 VICR map02020 T regulator COG0745 Cluster_438499 V1002517 PNCA map00760,map01100 Q isochorismatase COG1335 Cluster_444508 V1002518 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_364907 V1002519 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_920408 V1002520 SP_0122 S UPF0356 protein COG5503 Cluster_660231 V1002522 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_656090 V1002523 RBFA J Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) COG0858 Cluster_304853 V1002526 SP_2113 S membrAne COG1284 Cluster_473072 V1002527 NQR map00051,map00363,map00591,map00625,map00650,map01100,map01120 S Nadph-dependent fmn reductase COG0431 Cluster_346938 V1002528 ACUB S (CBS) domain COG0517 Cluster_631875 V1002529 S Membrane COG4129 Cluster_609553 V1002530 GLNR K Transcriptional regulator COG0789 Cluster_788334 V1002531 S NA 111SV Cluster_493977 V1002532 P NA 1205J Cluster_307625 V1002534 M Collagen binding domain COG4932 Cluster_854654 V1002536 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_588410 V1002537 XYLG S ABC transporter COG3845 Cluster_358408 V1002538 METN map02010 P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COG1135 Cluster_556950 V1002541 S NA 0ZAU4 Cluster_308985 V1002543 RNY S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 Cluster_308986 V1002544 METE map00270,map00450,map01100,map01110,map01230 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) COG0620 Cluster_484403 V1002545 CPMA S 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase COG1691 Cluster_310409 V1002547 map00270,map00450,map00920,map01100,map01110,map01230 E Cys met metabolism pyridoxal-phosphate-dependent COG0626 Cluster_496491 V1002548 GNTK map00030,map01100,map01110,map01120 G Gluconate kinase COG1070 Cluster_311946 V1002549 S Xanthine uracil vitamin C permease COG2252 Cluster_313385 V1002550 DEAD map03018 L RNA helicase COG0513 Cluster_311947 V1002551 NDH map00190 C NADH dehydrogenase COG1252 Cluster_311948 V1002552 M Cell Wall COG2866 Cluster_311949 V1002553 AGAS map00250,map00520,map01100,map01110 M isomerase COG2222 Cluster_322638 V1002554 NORA G Major facilitator superfamily MFS_1 0XQPT Cluster_358409 V1002555 PUTP E SSS family proline sodium (Na ) symporter COG0591 Cluster_327249 V1002558 METE map00270,map00450,map01100,map01110,map01230 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) COG0620 Cluster_737144 V1002559 TATD L Hydrolase, tatD family COG0084 Cluster_456451 V1002560 RNMV L Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) COG1658 Cluster_314987 V1002561 ARCD S c4-dicarboxylate anaerobic carrier COG1288 Cluster_318081 V1002562 E amino acid COG0531 Cluster_408417 V1002564 M Cna protein B-type domain protein COG4932 Cluster_444509 V1002565 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_408418 V1002566 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_804209 V1002567 BL02899 K Transcriptional regulator COG1476 Cluster_343790 V1002568 BOPA E Extracellular solute-binding protein, family 5 COG0747 Cluster_319628 V1002570 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_458357 V1002573 S Acetyltransferase GNAT Family 11VTQ Cluster_334685 V1002574 POTB map02010 P ABC transporter, permease COG1176 Cluster_444510 V1002575 PI346 L dna replication protein COG1484 Cluster_784295 V1002576 S NA 123QA Cluster_506613 V1002577 SODA map04146,map05016 P Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) COG0605 Cluster_408419 V1002579 DRRA map02010 S ABC transporter COG4586 Cluster_704563 V1002582 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_421110 V1002583 G Exopolysaccharide biosynthesis protein COG4632 Cluster_321063 V1002584 S NA 122BD Cluster_322639 V1002585 ADHE map00010,map00051,map00071,map00350,map00362,map00363,map00591,map00620,map00621,map00622,map00625,map00626,map00650,map01100,map01110,map01120 C alcohol dehydrogenase COG1454 Cluster_322640 V1002586 PEPD E Dipeptidase COG4690 Cluster_343791 V1002587 CLPL O ATP-dependent Clp protease ATP-binding subunit COG0542 Cluster_322641 V1002588 TCRY T Histidine kinase 0XNMH Cluster_337738 V1002589 MALX map02010 G extracellular solute-binding protein family 1 COG2182 Cluster_396175 V1002590 RPLY map03010 J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) COG1825 Cluster_324186 V1002591 SP_0092 G extracellular solute-binding protein family 1 COG1653 Cluster_385455 V1002592 YEAZ O Peptidase M22 Glycoprotease COG1214 Cluster_710739 V1002593 S NA 121RH Cluster_324187 V1002598 ADHE map00010,map00051,map00071,map00350,map00362,map00363,map00591,map00620,map00621,map00622,map00625,map00626,map00650,map01100,map01110,map01120 C Aldehyde-alcohol dehydrogenase 2 COG1454 Cluster_324188 V1002599 map02010 P Zinc ABC superfamily ATP binding cassette transporter, binding protein COG3443 Cluster_440484 V1002600 YHAM S Metal Dependent Phosphohydrolase COG3481 Cluster_438565 V1025803 S Toprim domain protein 0ZC02 Cluster_440543 V1025806 COXB map00190,map00910,map01100 C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) COG2010 Cluster_624513 V1025810 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_904041 V1025812 NUSA K Transcription elongation factor NusA COG0195 Cluster_438566 V1025814 S Ragb susd domain-containing protein 0XQZA Cluster_440544 V1025815 S integral membrane protein 11JQ4 Cluster_440546 V1025820 MOAB map00790,map01100,map04122 H Molybdenum cofactor synthesis domain protein COG0521 Cluster_440547 V1025821 I Diacylglycerol kinase COG1597 Cluster_440548 V1025823 YEHB map05133 M outer membrane usher protein COG3188 Cluster_765331 V1025825 S virulence-like protein 0ZW8F Cluster_660334 V1025826 S NA 0YJPQ Cluster_440549 V1025827 S Pfam:YadA 0YNSE Cluster_440550 V1025828 FTSK D cell division protein FtsK COG1674 Cluster_440551 V1025829 map02020 V acriflavin resistance protein COG0841 Cluster_440552 V1025830 T Histidine kinase 11GUU Cluster_462595 V1025831 ADH map00010,map00051,map00071,map00350,map00363,map00591,map00625,map00626,map00650,map00830,map00980,map00982,map01100,map01110,map01120 C alcohol dehydrogenase COG1063 Cluster_477465 V1025834 RLMH S Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) COG1576 Cluster_442561 V1025838 S NA 0Y05K Cluster_440553 V1025841 GALU map00040,map00052,map00500,map00520,map01100,map01110 M UTP-glucose-1-phosphate uridylyltransferase COG1210 Cluster_530999 V1025842 DGT map00230 F deoxyguanosinetriphosphate triphosphohydrolase-like protein COG0232 Cluster_519836 V1025844 HSP map04141 O Heat shock protein COG0071 Cluster_442562 V1025845 VGRG2 M Rhs element vgr protein COG4253 Cluster_442563 V1025847 M YD repeat protein COG3209 Cluster_442564 V1025849 S ''Winged helix'' DNA-binding domain 17X7Y@proNOG Cluster_442565 V1025850 LIPT map00363,map00960,map01120 I Carboxylesterase COG2272 Cluster_827742 V1025851 CCOQ map00190,map01100,map02020 C cytochrome C oxidase 17SKU@proNOG Cluster_730754 V1025852 CCOP map00190,map01100,map02020 C C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity) COG2010 Cluster_442566 V1025853 QSEC map02020 T Histidine kinase 174CG@proNOG Cluster_442568 V1025856 PONA map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_548298 V1025857 U biopolymer transport protein 11Q0R Cluster_442569 V1025858 S Replication initiator protein 11Z32 Cluster_533773 V1025859 MELB G melibiose sodium symporter COG2211 Cluster_867076 V1025860 G Major Facilitator superfamily 0XQFH Cluster_740702 V1025861 S ABC transporter, ATPase COG3044 Cluster_442570 V1025862 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_831340 V1025863 YOAH S UPF0181 protein COG3140 Cluster_899618 V1025864 YOAC S Uncharacterized protein yoac 17IHA@proNOG Cluster_442571 V1025868 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_444567 V1025870 S Transposition protein 16TUU@proNOG Cluster_499213 V1025872 URTD2 map02010 E abc transporter atp-binding protein COG4674 Cluster_444568 V1025873 S NA COG4926 Cluster_528250 V1025874 S NA 122W5 Cluster_442572 V1025876 U, W Pfam:YadA COG5295 Cluster_477466 V1025879 S Cholesterol esterase 11S9U Cluster_444569 V1025880 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_799940 V1025883 PILE S TM2 domain containing protein COG2314 Cluster_444570 V1025884 map00071,map00280,map00281,map00410,map00640,map01100,map01110,map03320 I acyl-Coa dehydrogenase 16PRN@proNOG Cluster_444571 V1025885 DSBD O Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) COG4232 Cluster_444572 V1025886 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_691196 V1025887 SCLAV_0470 C, H Monooxygenase COG0654 Cluster_444573 V1025890 PEPN map00480,map01100 E Peptidase M1 membrane alanine aminopeptidase COG0308 Cluster_444574 V1025891 PCP O Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) COG2039 Cluster_479833 V1025892 K transcriptional regulator 0YJ72 Cluster_506681 V1025893 S NA 11J85 Cluster_804283 V1025894 RPMC map03010 J 50s ribosomal protein l29 COG0255 Cluster_664546 V1025895 YHJJ O peptidase COG0612 Cluster_566168 V1025899 S Protein of unknown function (DUF1573) 120RE Cluster_448588 V1025903 S NA 0YJ4B Cluster_528251 V1025904 PHNB S Glyoxalase Bleomycin resistance protein (Dioxygenase COG2764 Cluster_522536 V1025905 CRTB map00906,map01062,map01100,map01110 I phytoene synthase COG1562 Cluster_533774 V1025906 S von Willebrand factor COG1721 Cluster_519837 V1025908 S Phage virion morphogenesis family 1281C Cluster_450574 V1025909 ADK map00230,map00240,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_444575 V1025910 S ribonuclease BN COG1295 Cluster_591866 V1025912 map00630,map01100 G Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) COG3622 Cluster_491607 V1025913 FOXA P tonB-dependent siderophore receptor COG1629 Cluster_468901 V1025918 S NA 17DAS@proNOG Cluster_446583 V1025919 K Transcriptional Regulator AraC Family COG3664 Cluster_446584 V1025920 GABD2 map00010,map00040,map00053,map00071,map00250,map00280,map00310,map00330,map00340,map00350,map00360,map00380,map00410,map00561,map00620,map00625,map00640,map00643,map00650,map00903,map01100,map01110,map01120 C Dehydrogenase COG1012 Cluster_788413 V1025921 SMP S Membrane COG3726 Cluster_765332 V1025925 LYSR K LysR family (Transcriptional regulator COG0583 Cluster_639995 V1025926 LIP map00561,map01100 S Triacylglycerol lipase COG1075 Cluster_460473 V1025928 PLSX map00561,map00564,map01100 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) COG0416 Cluster_652023 V1025929 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_908214 V1025930 SCLAV_2340 K Transcriptional regulator 11HTM Cluster_446585 V1025931 CFA M cyclopropane-fatty-acyl-phospholipid synthase COG2230 Cluster_854708 V1025932 S NA 0ZHU9 Cluster_740703 V1025935 RPSL map03010 J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) COG0048 Cluster_446587 V1025938 RPSB map03010 J 30S ribosomal protein S2 COG0052 Cluster_796136 V1025939 YTFK S Protein of unknown function (DUF1107) 17FB1@proNOG Cluster_448589 V1025941 U transfer protein 16RNB@proNOG Cluster_643912 V1025944 LYSC map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Aspartokinase COG0527 Cluster_448590 V1025945 YIDE P transport protein COG2985 Cluster_448591 V1025946 map02010,map02020 E amino acid ABC transporter substrate-binding protein, PAAT family COG0834 Cluster_761367 V1025948 PILD map03070 N, O, U Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) COG1989 Cluster_686574 V1025949 PILC map03070 U type II secretion system COG1459 Cluster_448592 V1025950 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_595279 V1025951 E peptidase 0XRNU Cluster_714261 V1025954 HUP L DNA-binding protein COG0776 Cluster_536681 V1025956 S NA 0ZHU9 Cluster_448593 V1025957 O alkyl hydroperoxide reductase COG3634 Cluster_448594 V1025958 LEUA map00290,map00620,map01100,map01110,map01210,map01230 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) COG0119 Cluster_598862 V1025960 S NA 17JG5@proNOG Cluster_448595 V1025962 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_448596 V1025965 M efflux transporter, rnd family, mfp subunit COG0845 Cluster_448597 V1025974 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin 0XQTW Cluster_620762 V1025975 SFMA map05133 S Fimbrial protein 17BUR@proNOG Cluster_450575 V1025976 G Major Facilitator 0XPHU Cluster_468902 V1025977 ISPH map00900,map01100,map01110,map03010 I Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) COG0761 Cluster_531000 V1025978 YDAG S general stress protein COG3871 Cluster_664547 V1025981 S NA 0ZHU9 Cluster_450576 V1025982 PBRT P iron permease COG0672 Cluster_660336 V1025983 YAFS map00340,map00350,map00624,map01120 Q Methyltransferase COG0500 Cluster_839038 V1025984 PILI map02020 N, T chew protein COG0835 Cluster_720796 V1025986 S Membrane COG0398 Cluster_450578 V1025987 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins COG0706 Cluster_560076 V1025988 TRPE map00400,map01100,map01110,map01230 E synthase component I COG0147 Cluster_450579 V1025989 map03070,map04626,map05133 M Outer membrane efflux protein COG1538 Cluster_727385 V1025990 E, G Membrane COG0697 Cluster_491608 V1025992 MDTN V Multidrug resistance protein mdtN COG1566 Cluster_506682 V1025995 DNAC L DNA replication protein COG1484 Cluster_452527 V1025997 PILV U (type IV) pilus 1750S@proNOG Cluster_785390 V1259824 S NA 0ZHU9 Cluster_458968 V1259825 M glycosyl transferase family COG1819 Cluster_649150 V1259828 KATG map00360,map00380,map00940,map01100 P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) COG0376 Cluster_592836 V1259831 L Domain protein COG0507 Cluster_461028 V1259832 AHCY map00270,map01100 H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) COG0499 Cluster_461030 V1259835 HELY L helicase COG4581 Cluster_461033 V1259842 MOEB map04122 H UBA THIF-type NAD FAD binding protein COG0476 Cluster_461034 V1259846 NUOD map00190,map00910,map01100 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) COG0649 Cluster_463139 V1259850 CLPB O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_461036 V1259855 ILVA map00260,map00290,map01100,map01110,map01230 E Threonine dehydratase COG1171 Cluster_463143 V1259860 map00230 L Helicase COG0553 Cluster_523286 V1259888 AMTB P Ammonium transporter 16PRG@proNOG Cluster_485100 V1259902 ARGG map00250,map00330,map01100,map01110,map01230 E Citrulline--aspartate ligase COG0137 Cluster_467317 V1259904 RSMF J Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA (By similarity) COG3270 Cluster_467322 V1259917 S peptidase C14 caspase catalytic subunit P20 0ZVF2 Cluster_531779 V1259918 HISG map00340,map01100,map01110,map01230 E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) COG0040 Cluster_469426 V1259931 AROP E amino acid COG1113 Cluster_467328 V1259933 PRUA map00250,map00330,map01100,map01110 C Delta-1-pyrroline-5-carboxylate dehydrogenase COG1012 Cluster_614394 V1259955 VDLC S short-chain dehydrogenase reductase COG1028 Cluster_471590 V1259961 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_469440 V1259963 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_471593 V1259972 HRPA L ATP-dependent helicase COG1643 Cluster_607022 V1259978 ASD map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E aspartate-semialdehyde dehydrogenase (EC 1.2.1.11 COG0136 Cluster_471596 V1259982 CSHA map03018 L atp-dependent rna helicase COG0513 Cluster_473682 V1259987 map00330,map01100,map01110,map01210,map01230 E peptidase COG0624 Cluster_473684 V1259989 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_471599 V1259996 RALF map05134 S RalF protein, translocated into host cells by the Dot Icm system COG5307 Cluster_473686 V1259999 map00361,map00364,map00623,map01100,map01110,map01120 Q dienelactone hydrolase COG0412 Cluster_471602 V1260002 PKNA T serine threonine protein kinase COG0515 Cluster_489741 V1260011 map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120 I Enoyl-CoA hydratase 16R12@proNOG Cluster_725049 V1260012 LYSP E permease COG0833 Cluster_473691 V1260015 NAMA map00633,map01120 C flavin oxidoreductase COG1902 Cluster_475863 V1260034 map00680,map00982,map01120 P Monooxygenase COG2072 Cluster_475864 V1260035 BIOA map00780,map01100 H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) COG0161 Cluster_475866 V1260042 V abc transporter atp-binding protein COG1131 Cluster_785391 V1260043 S NA 0ZHU9 Cluster_715131 V1260044 S NA 0ZHU9 Cluster_475867 V1260045 CLPB O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_475868 V1260049 T Serine Threonine protein kinase with WD40 repeats 0YMKP Cluster_554931 V1260051 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_478043 V1260053 TOXC S WD domain, G-beta repeat COG2319 Cluster_625576 V1260065 S NA 0ZHU9 Cluster_478048 V1260067 O AAA ATPase COG0465 Cluster_478050 V1260069 MMSB map00280,map00630,map01100 I 3-hydroxyisobutyrate dehydrogenase COG2084 Cluster_478053 V1260073 FUSA2 J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_478057 V1260080 FBP map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map04910 G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 COG0158 Cluster_586156 V1260081 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_480449 V1260086 ACNA map00020,map00300,map00630,map00720,map01100,map01110,map01120,map01210,map01230 C Aconitate hydratase COG1048 Cluster_480452 V1260091 PROC map00330,map01100,map01110,map01230 E pyrroline-5-carboxylate reductase COG0345 Cluster_480456 V1260095 YBFF map00130,map01100,map01110 S Alpha Beta Hydrolase COG0596 Cluster_480457 V1260096 S repeat protein COG0457 Cluster_480458 V1260097 YCHF J gtp-binding protein COG0012 Cluster_629286 V1260104 GLOA map00620,map04011 C Lactoylglutathione lyase 177R5@proNOG Cluster_543190 V1260108 S Lipase (EC 0XS3K Cluster_482773 V1260110 T Leucine-rich repeAt COG4886 Cluster_482775 V1260113 PACL P Atpase, p-type (Transporting), had superfamily, subfamily ic COG0474 Cluster_579722 V1260115 SODA map04146,map05016 P radicals which are normally produced within the cells and which are toxic to biological systems COG0605 Cluster_482776 V1260117 YEJH L type iii restriction protein res subunit COG1061 Cluster_531780 V1260123 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_482781 V1260125 SNF L snf2 family COG0553 Cluster_725050 V1260132 METB map00260,map00270,map00450,map00920,map01100,map01110,map01230 E Cystathionine gamma-synthase COG0626 Cluster_482784 V1260134 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_485103 V1260137 MNTH P H( )-stimulated, divalent metal cation uptake system (By similarity) COG1914 Cluster_485104 V1260138 PACL2 map04260,map04911,map04960,map04961,map04964,map04970,map04971,map04972,map04973,map04974,map04976,map04978 P ATPase, P-type transporting, HAD superfamily, subfamily IC COG0474 Cluster_485105 V1260141 C PBS lyase HEAT domain protein repeat-containing protein COG1413 Cluster_517979 V1260146 YHES S ABC transporter COG0488 Cluster_485108 V1260147 CYSJ map00920,map01100,map01120 P Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) COG0369 Cluster_485109 V1260148 NEMA map00633,map01120 C Nadh flavin oxidoreductase nadh oxidase COG1902 Cluster_487396 V1260159 LYSP E permease COG0833 Cluster_487398 V1260163 LYSP E permease COG0833 Cluster_487402 V1260170 PURE map00230,map01100,map01110 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) COG0041 Cluster_507410 V1260172 LYSP E permease COG0833 Cluster_603405 V1260185 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_487410 V1260195 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_489750 V1260203 T serine threonine protein kinase COG0515 Cluster_489754 V1260208 SDSL map00260,map00290,map01100,map01110,map01230 E pyridoxal-5'-phosphate-dependent protein beta subunit COG1171 Cluster_702398 V1260224 S NA 0ZHU9 Cluster_492225 V1260226 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_489758 V1260228 PYRE map00240,map00983,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_492227 V1260229 PSED_3799 map00630,map00910 C Formamidase (EC 3.5.1.49) COG2421 Cluster_492228 V1260232 LEUC map00290,map00660,map01100,map01110,map01210,map01230 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) COG0065 Cluster_492230 V1260234 S WD-repeat protein 0XP3K Cluster_492231 V1260235 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_528963 V1260238 LEUC map00290,map00660,map01100,map01110,map01210,map01230 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) COG0065 Cluster_492234 V1260243 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_492239 V1260249 GPSA map00564 C NADPH-dependent glycerol-3-phosphate dehydrogenase COG0240 Cluster_494722 V1260265 ASPC map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_492246 V1260267 APRA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_494726 V1260275 HEMA map00260,map00780,map00860,map01100 H 5-aminolevulinate synthase COG0156 Cluster_494728 V1260279 NORQ S ATPase associated with various cellular activities aaa_5 COG0714 Cluster_494733 V1260295 S NA 0ZHU9 Cluster_731633 V1260313 O Inherit from COG: ubiquitin COG5272 Cluster_497234 V1260318 S repeat-containing protein 0XP3K Cluster_702399 V1260326 S WD-repeat protein 0XP3K Cluster_649152 V1260334 S NA 0ZHU9 Cluster_715132 V1260344 S NB-ARC domain 0XP3K Cluster_499890 V1260349 MT0451 map03050,map04141,map05134 O AAA ATPase COG0464 Cluster_499891 V1260350 SUA J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0009 Cluster_515300 V1260353 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_499900 V1260366 TESB map01040 I acyl-CoA thioesterase COG1946 Cluster_502434 V1260389 PRKC T serine threonine protein kinase COG2815 Cluster_502435 V1260390 CYSJ map00920,map01100,map01120 P Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) COG0369 Cluster_502437 V1260394 MNTH P H( )-stimulated, divalent metal cation uptake system (By similarity) COG1914 Cluster_504835 V1260405 I fatty acid hydroxylase COG3000 Cluster_504838 V1260413 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_531783 V1260417 FDH map00630,map00680,map01100,map01120 C formate dehydrogenase COG1052 Cluster_504842 V1260432 SUCC map00020,map00640,map00660,map00720,map01100,map01110,map01120 C Succinyl-CoA synthetase subunit beta COG0045 Cluster_554933 V1260437 Q Fumarylacetoacetate hydrolase COG0179 Cluster_504846 V1260441 RIBA map00740,map01100 H Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) COG0807 Cluster_504848 V1260449 ACCC map00061,map00253,map00280,map00281,map00330,map00620,map00630,map00640,map00720,map00791,map01100,map01110,map01120 I acetyl-CoA carboxylase biotin carboxylase COG2049 Cluster_504850 V1260451 YWDH map00010,map00040,map00053,map00071,map00280,map00281,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00626,map00640,map00903,map01100,map01110,map01120 C Aldehyde dehydrogenase COG1012 Cluster_507413 V1260457 EBH S cell wall associated fibronectin-binding protein 129KW Cluster_507414 V1260461 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_534579 V1260488 ACNA map00020,map00300,map00630,map00720,map01100,map01110,map01120,map01210,map01230 C Aconitate hydratase COG1048 Cluster_507427 V1260489 S NA 0XRN7 Cluster_523287 V1260494 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_510022 V1260497 S hydrolase 175ZT@proNOG Cluster_510025 V1260507 PSD map00564,map01100 I phosphatidylserine decarboxylase COG0688 Cluster_512591 V1260508 GLNII map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG0174 Cluster_512594 V1260516 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_554934 V1260517 map02020,map04115,map04210,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05168,map05200,map05210,map05222,map05416 K WD-40 repeat-containing protein 0XP3K Cluster_683442 V1260520 S NA 0ZHU9 Cluster_512598 V1260523 RIBB map00740,map01100 H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) COG0807 Cluster_512600 V1260527 T WD-40 repeat 16RQP@proNOG Cluster_515303 V1260538 LIPA map00785,map01100 H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) COG0320 Cluster_515304 V1260541 DLD map00620,map00630,map01100,map01110,map01120 C FAD linked oxidase domain protein COG0277 Cluster_618148 V1260544 T Protein tyrosine kinase 0XP3K Cluster_515310 V1260557 GABD map00250,map00350,map00650,map01100,map01120 C Dehydrogenase COG1012 Cluster_515312 V1260560 SUCA map00020,map00310,map00380,map01100,map01110,map01120 C 2-oxoglutarate dehydrogenase, E1 COG0567 Cluster_515314 V1260562 L Domain protein COG0507 Cluster_515316 V1260565 YPRA L dEAD DEAH box helicase COG1205 Cluster_515317 V1260566 RLUA J Pseudouridine synthase COG0564 Cluster_744910 V1260569 S WD-repeat protein 0XP3K Cluster_665772 V1260579 RHLE map03018 L atp-dependent rna helicase COG0513 Cluster_515327 V1260588 CATA map00361,map00362,map00364,map00623,map01100,map01120 Q catechol 1,2-dioxygenase COG3485 Cluster_517988 V1260606 ATZF map00330,map00791,map00970,map01100,map01120 E Allophanate hydrolase COG0154 Cluster_840251 V1260614 S NA 0ZHU9 Cluster_557850 V1260623 PCKA map00010,map00020,map00620,map00710,map01100,map01110,map01120 C Phosphoenolpyruvate Carboxylase COG1866 Cluster_599815 V1260630 PURN map00230,map00670,map01100,map01110 F phosphoribosylglycinamide formyltransferase COG0299 Cluster_520543 V1260631 HEMA map00260,map00780,map00860,map01100 H 5-aminolevulinate synthase COG0156 Cluster_579723 V1260633 CLPB O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_520544 V1260634 P Atpase, p-type (Transporting), had superfamily, subfamily ic COG0474 Cluster_520549 V1260646 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_582963 V1260659 map00052,map00500,map01100 G Glycoside hydrolase family 31 COG1501 Cluster_520553 V1260664 VISC map00130,map00340,map00361,map00363,map00623,map00624,map00626,map00627,map00903,map00945,map01100,map01110,map01120 C, H ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family COG0654 Cluster_520556 V1260669 CARA map00240,map00250,map01100 F carbamoyl-phosphate synthetase glutamine chain COG0505 Cluster_520560 V1260678 ARGD map00300,map00330,map01100,map01110,map01120,map01210,map01230 E Acetylornithine aminotransferase COG4992 Cluster_520562 V1260682 SDHB map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120 C succinate dehydrogenase COG0479 Cluster_520564 V1260685 METB map00260,map00270,map00450,map00920,map01100,map01110,map01230 E Cystathionine gamma-synthase COG0626 Cluster_836332 V1260687 MTCA1 map00910 P carbonic anhydrase COG0288 Cluster_523296 V1260691 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_537476 V1260696 CAX P Calcium Proton COG0387 Cluster_618150 V1260703 NUOD map00190,map00910,map01100 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) COG0649 Cluster_523301 V1260705 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG3848 Cluster_523302 V1260706 SULP P sulfate transporter COG0659 Cluster_523305 V1260710 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_523306 V1260711 YHES S Abc transporter COG0488 Cluster_692343 V1260719 map02020,map02030 S Methyl-accepting chemotaxis sensory transducer 0YD9G Cluster_523310 V1260720 PETC map00190,map00910,map01100,map02020,map04260,map05010,map05012,map05016 C cytochrome c1 COG2857 Cluster_526197 V1260724 PLC map00562 S Phosphatidylinositol-specific phospholipase C 0ZKFY Cluster_692344 V1260727 S Inherit from COG: Protein of unknown function (DUF1093) COG5294 Cluster_526203 V1260745 map00909,map01100,map01110 C, H Squalene epoxidase COG0654 Cluster_526207 V1260754 GGT map00430,map00460,map00480,map00590,map01100 E Gamma-glutamyltranspeptidase (EC 2.3.2.2) COG0405 Cluster_526213 V1260763 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_528969 V1260778 XENB map00051,map00363,map00591,map00625,map00633,map00650,map01100,map01120 C Nadh flavin oxidoreductase nadh oxidase COG1902 Cluster_526217 V1260784 MVAA map00900,map01100,map01110,map04976 I reductase COG1257 Cluster_528970 V1260786 MT0451 map03050,map04141,map05134 O AAA ATPase COG0464 Cluster_528972 V1260788 YQFO S dinuclear metal center protein, YbgI family COG0327 Cluster_528977 V1260797 LYSP E permease COG0833 Cluster_531788 V1260810 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_531789 V1260811 map00521,map00562,map01100,map01110 I inositoL-3-phosphate synthase COG1260 Cluster_531795 V1260821 T serine threonine protein kinase COG0515 Cluster_531800 V1260832 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_531808 V1260843 LYSP E permease COG0833 Cluster_534582 V1260845 SNF L SNF2 family COG0553 Cluster_531809 V1260847 T serine threonine protein kinase COG0515 Cluster_534585 V1260854 BMUL_5891 J Metallo-Beta-Lactamase COG1236 Cluster_534587 V1260857 TKTA map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_531812 V1260859 T Serine threonine protein kinase with WD-40 repeats COG0515 Cluster_531814 V1260862 GABD map00250,map00310,map00350,map00650,map01100,map01120 C dehydrogenase COG1012 Cluster_534589 V1260863 SSCG_01206 map01040,map03320 I desaturase COG1398 Cluster_531817 V1260868 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_534597 V1260882 HRPB L ATP-dependent helicase COG1643 Cluster_534599 V1260885 GATB map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 Cluster_534602 V1260896 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_537484 V1260902 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_557852 V1260928 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_537495 V1260936 SUCA map00020,map00310,map00380,map01100,map01110,map01120 C 2-oxoglutarate dehydrogenase, E1 COG0567 Cluster_610677 V1260948 HEMB map00860,map01100,map01110 H delta-aminolevulinic acid dehydratase COG0113 Cluster_540264 V1260951 TYNA map00260,map00350,map00360,map00410,map00950,map00960,map01100,map01110 Q amine oxidase COG3733 Cluster_540265 V1260953 T WD domain Cytochrome c family protein 16RQP@proNOG Cluster_540276 V1260981 S Lipase (EC 0XS3K Cluster_540278 V1260986 NEMA map00633,map01120 C NADH flavin oxidoreductase COG1902 Cluster_543191 V1260991 map00230 L Helicase COG0553 Cluster_599817 V1260992 CBPA O DnaJ domain protein COG2214 Cluster_543192 V1260993 M Glycoside hydrolase, family 81 COG5498 Cluster_592841 V1260994 O Chaperonin Cpn60 TCP-1 COG0459 Cluster_540284 V1261001 P drug resistance transporter emrb qaca subfamily 0XNN3 Cluster_543195 V1261003 NUOG map00190,map00910,map01100 C NADH dehydrogenase subunit g COG1034 Cluster_543199 V1261010 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E amino acid aminotransferase COG0115 Cluster_543203 V1261015 O Chaperonin Cpn60 TCP-1 COG0459 Cluster_543204 V1261019 GDH map00030,map00061,map00780,map01040,map01100,map01120 S Short-chain dehydrogenase reductase Sdr COG1028 Cluster_543210 V1261033 GABD map00250,map00310,map00350,map00650,map01100,map01120 C Dehydrogenase COG1012 Cluster_546127 V1261034 map02010 S ABC transporter COG4178 Cluster_546135 V1261058 P drug resistance transporter, EmrB QacA subfamily 0XQZX Cluster_546140 V1261070 S NA 121IM Cluster_546146 V1261081 IPDC map00380,map01100 E decarboxylase COG3961 Cluster_546149 V1261094 IPDC map00380,map01100 E decarboxylase COG3961 Cluster_549173 V1261107 ATPA map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) COG1155 Cluster_549174 V1261110 O Chaperonin Cpn60 TCP-1 COG0459 Cluster_549180 V1261123 METY map00270,map01100 E o-acetylhomoserine COG2873 Cluster_552052 V1261129 S NA 0ZHU9 Cluster_549184 V1261144 Q Male sterility protein COG3320 Cluster_552060 V1261147 NUOE map00190,map00910,map01100 C subunit e COG1905 Cluster_552063 V1261152 P drug resistance transporter emrb qaca subfamily 16S8F@proNOG Cluster_554948 V1261188 HEMB map00860,map01100,map01110 H delta-aminolevulinic acid dehydratase COG0113 Cluster_554952 V1261195 THRC map00260,map00750,map01100,map01120,map01230 E Threonine synthase COG0498 Cluster_557857 V1261217 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_755156 V1261226 MSMK map02010 G ABC transporter, ATP-binding protein COG3839 Cluster_777525 V1261229 MSRB O reductase COG0229 Cluster_557866 V1261238 PYC map00020,map00620,map00720,map01100,map01120,map01230 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) COG1038 Cluster_557868 V1261240 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_557870 V1261244 IPDC map00380,map01100 E decarboxylase COG3961 Cluster_557871 V1261245 S ybak prolyl-trna synthetase COG3760 Cluster_560904 V1261248 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G ec 2.7.1.11 COG0205 Cluster_557872 V1261249 FOLE map00790,map01100 H GTP cyclohydrolase i COG0302 Cluster_560906 V1261258 B, K histone acetyltransferase COG1243 Cluster_560907 V1261261 ISCU C May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins COG0822 Cluster_560911 V1261267 NTPB map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) COG1156 Cluster_560930 V1261301 IPDC map00380,map01100 E decarboxylase COG3961 Cluster_563894 V1261317 ALLB map00230,map00240,map01100,map01120 F Allantoinase (EC 3.5.2.5) COG0044 Cluster_563898 V1261327 map00290,map00300,map00620,map01100,map01110,map01210,map01230 E Homocitrate synthase COG0119 Cluster_661559 V1261329 S Inherit from NOG: domain protein 18D01@proNOG Cluster_563902 V1261332 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_563903 V1261334 FADA map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120 I acetyl-coa acetyltransferase COG0183 Cluster_670070 V1261347 GCVP map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG1003 Cluster_567083 V1261351 T serine threonine protein kinase COG0515 Cluster_567088 V1261362 BTAA map00564 I S-adenosylmethionine diacylglycerol 3-amino-3-carboxypropyl COG5379 Cluster_567089 V1261363 map00260,map00440,map01100 E oxidoreductase COG2303 Cluster_567091 V1261367 T serine threonine protein kinase COG0515 Cluster_567092 V1261368 S NA 1536E@plaNOG Cluster_570160 V1261381 C Monooxygenase 0XNPZ Cluster_570162 V1261384 RHLE map03018 L atp-dependent rna helicase COG0513 Cluster_657351 V1261389 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_748264 V1261397 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_748265 V1261398 S NA 17D58@proNOG Cluster_570169 V1261409 LYSC map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Aspartokinase COG0527 Cluster_570170 V1261411 map01054 Q synthetase COG0318 Cluster_603412 V1261444 S ABC transporter COG0488 Cluster_573388 V1261449 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_573396 V1261459 WRBA S NAD(P)H quinone oxidoreductase COG0655 Cluster_573397 V1261460 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_573400 V1261463 LYSP E permease COG0833 Cluster_570191 V1261464 SUCA map00020,map00310,map00380,map01100,map01110,map01120 C 2-oxoglutarate dehydrogenase, E1 COG0567 Cluster_573409 V1261476 S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase COG0388 Cluster_573412 V1261481 KMO map00380,map01100 H Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) COG0654 Cluster_576605 V1261510 GALT map00052,map00520,map01100,map01110 G galactose-1-phosphate uridylyltransferase COG1085 Cluster_573426 V1261512 SDHA map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map05134 C Succinate dehydrogenase (Flavoprotein subunit) COG1053 Cluster_614400 V1261523 RECQ map03018 L ATP-dependent DNA helicase RecQ COG0514 Cluster_576616 V1261535 map00230,map00240,map01100 F HAM1 family COG0127 Cluster_653224 V1261545 METE map00270,map00450,map01100,map01110,map01230 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) COG0620 Cluster_579732 V1261557 ACSA map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120 I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) COG0365 Cluster_621797 V1261562 UBIE map00130,map01100,map01110 H Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) COG2226 Cluster_579736 V1261567 LYSP E permease COG0833 Cluster_579740 V1261575 S WD-repeat protein 0XP3K Cluster_579743 V1261580 S short-chain dehydrogenase reductase 176BU@proNOG Cluster_579747 V1261584 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_582970 V1261601 M Glycoside hydrolase, family 81 COG5498 Cluster_645043 V1261603 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_582974 V1261614 MT0451 map03050,map04141,map05134 O AAA ATPase COG0464 Cluster_582975 V1261616 PCKA map00010,map00020,map00620,map00710,map01100,map01110,map01120 C Phosphoenolpyruvate Carboxylase COG1866 Cluster_582985 V1261629 RHLE2 map03018 L atp-dependent rna helicase COG0513 Cluster_582991 V1261643 LEUA map00290,map00620,map01100,map01110,map01210,map01230 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) COG0119 Cluster_653225 V1261648 DBPA map03018 L atp-dependent rna helicase COG0513 Cluster_586166 V1261650 UGPA map00040,map00052,map00500,map00520,map01100,map01110 G UTP-glucose-1-phosphate uridylyltransferase COG4284 Cluster_582993 V1261653 T WD domain Cytochrome c family protein 16RQP@proNOG Cluster_586167 V1261654 T Histidine kinase 16PBK@proNOG Cluster_586171 V1261664 map04113 G transporter 0XNQK Cluster_586183 V1261689 RHLE map03018 L Helicase COG0513 Cluster_589449 V1261701 FAS map00061,map01100 I fatty acid synthase COG4982 Cluster_586186 V1261712 E Serine carboxypeptidase COG2939 Cluster_589459 V1261723 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G ec 2.7.1.11 COG0205 Cluster_589461 V1261727 MT0156 map00051,map00362,map00363,map00591,map00625,map00626,map00650,map00903,map01100,map01110,map01120 I Short-chain dehydrogenase reductase Sdr COG1028 Cluster_589465 V1261733 map00051,map04066 G Phosphoglycerate mutase COG0406 Cluster_589466 V1261735 PYC map00020,map00620,map00720,map01100,map01120,map01230 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) COG1038 Cluster_589467 V1261736 map00500,map04151,map04910 M synthase COG0438 Cluster_614402 V1261745 L helicase COG0553 Cluster_721690 V1261749 NDH map00190 C NADH dehydrogenase COG1252 Cluster_592853 V1261760 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_592861 V1261774 CLPB O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_592862 V1261778 METE map00270,map00450,map01100,map01110,map01230 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) COG0620 Cluster_592868 V1261790 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_592870 V1261798 GUTB map00051,map01100 C Dehydrogenase COG1063 Cluster_491609 V1026002 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii subunits gamma and tau COG2812 Cluster_450580 V1026003 map00564,map01100 I phosphatidylserine decarboxylase COG0688 Cluster_452528 V1026005 PLPD S K07001 NTE family protein COG1752 Cluster_450581 V1026007 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_452529 V1026009 D Cobyrinic acid ac-diamide synthase COG1192 Cluster_761368 V1026010 S NA 0ZHU9 Cluster_450582 V1026011 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_733953 V1026012 S Protein of unknown function (DUF3540) 17FUI@proNOG Cluster_757753 V1026013 S NA 17CN1@proNOG Cluster_456493 V1026014 DNAJ O DnaJ domain protein COG0484 Cluster_557023 V1026015 GATA map00970,map01100 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) COG0154 Cluster_560077 V1026019 M Efflux transporter rnd family, mfp subunit 1755R@proNOG Cluster_895427 V1026024 S NA 17D58@proNOG Cluster_450584 V1026025 U, W Pfam:YadA COG5295 Cluster_450585 V1026026 map00300,map01100,map01210,map01230 K Transcriptional regulator COG1167 Cluster_595280 V1026029 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_566169 V1026030 YJGH J endoribonuclease L-psp COG0251 Cluster_452531 V1026031 AMRB V Multidrug efflux protein COG0841 Cluster_452532 V1026032 ACDB map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I acyl-CoA dehydrogenase COG1960 Cluster_479834 V1026033 USHA map00230,map00240,map00760,map01100,map01110 F 5'-nucleotidase (EC 3.1.3.5) 16S7F@proNOG Cluster_575684 V1026034 ACTP P heavy metal translocating p-type atpase COG2217 Cluster_499214 V1026035 NTH L Hhh-gpd family COG2231 Cluster_452533 V1026036 YIHS G N-acylglucosamine 2-epimerase COG2942 Cluster_452534 V1026037 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_620763 V1026038 UBIA H Prenyltransferase COG0382 Cluster_554136 V1026039 TADC U type ii secretion system COG2064 Cluster_691197 V1026043 G Major Facilitator superfamily 0Z6XG Cluster_452536 V1026047 MDH map00620,map00710,map01100,map01120,map02020 C malate dehydrogenase (Oxaloacetate-decarboxylating) COG0281 Cluster_509310 V1026048 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_908216 V1026049 S CAAX protease self-immunity 0YR70 Cluster_454567 V1026050 RHDA map00270,map01100,map04122 P sulfurtransferase COG2897 Cluster_454568 V1026052 CTAA map00190,map00860,map01100,map01110,map02020 O cytochrome oxidase assembly COG1612 Cluster_452537 V1026057 SCLAV_0672 P integral membrane protein COG1253 Cluster_454571 V1026059 M outer membrane autotransporter barrel domain protein COG3468 Cluster_452538 V1026061 PEPDA E Dipeptidase COG4690 Cluster_542275 V1026063 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_454573 V1026064 S NA 11G4S Cluster_452539 V1026065 ECHA3 map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120 I Enoyl-CoA hydratase COG1024 Cluster_454574 V1026068 S domain-containing protein 11PBU Cluster_452540 V1026069 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_454575 V1026070 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_454576 V1026071 S Baseplate J-like protein 173VM@proNOG Cluster_704638 V1026076 BMUL_4232 K Iclr family transcriptional regulator COG1414 Cluster_454577 V1026077 CYA map00230,map04113 T Adenylate cyclase COG2114 Cluster_454578 V1026078 L Dna topoisomerase COG0550 Cluster_714264 V1026079 Q Carotenoid oxygenase COG3670 Cluster_562980 V1026083 S Uncharacterized protein conserved in bacteria (DUF2272) COG4322 Cluster_456494 V1026087 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_635931 V1026089 ATPB map00190,map00195,map01100 C it plays a direct role in the translocation of protons across the membrane (By similarity) COG0356 Cluster_737223 V1026090 MSHB S Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) COG2120 Cluster_704639 V1026091 LPQW E Extracellular solute-binding protein, family 5 COG0747 Cluster_454579 V1026092 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_456496 V1026100 SASC S surface protein 11FPX Cluster_757754 V1026102 AAVE_2702 L Resolvase COG1961 Cluster_506683 V1026103 P Bile acid sodium symporter COG0798 Cluster_557024 V1026104 CBIO2 map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_566170 V1026108 S protein with cbs domains COG0517 Cluster_545257 V1026112 T PAS PAC sensor 16UVY@proNOG Cluster_456497 V1026113 S nucleoside recognition domain protein COG3314 Cluster_456498 V1026116 M outer membrane efflux protein 0XTC8 Cluster_471006 V1026117 AARI_34720 L Transposase COG3547 Cluster_456499 V1026118 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_673158 V1026120 map00240,map00983,map01100 F deaminase 11Y4T Cluster_456502 V1026122 CYDB map00190,map01100,map02020 C cytochrome D ubiquinol oxidase subunit II COG1294 Cluster_572460 V1026123 S mmge prpd family protein COG2079 Cluster_750746 V1026126 BMUL_5685 P RND family efflux transporter MFP subunit COG5569 Cluster_780126 V1026127 INFA J however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) COG0361 Cluster_456503 V1026128 S NA 0XNWW Cluster_624514 V1026129 GUDD map00053,map01100 M glucarate dehydratase COG4948 Cluster_908217 V1026130 GLXR map00280,map00630,map01100 I 2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60) COG2084 Cluster_456504 V1026133 ACIN_0074 L Transposase COG3464 Cluster_456505 V1026137 PEPC E aminopeptidase c COG3579 Cluster_562981 V1026138 GLPCD map00620 C FAD linked oxidase domain protein COG0277 Cluster_631974 V1026139 RCSB map02020 T regulatoR COG2197 Cluster_456506 V1026140 K LysR family Transcriptional regulator 173YD@proNOG Cluster_727386 V1026141 CCU S Protein of unknown function (DUF1643) COG4333 Cluster_458416 V1026145 BGLA map00010 G 6-phospho-beta-glucosidase (EC 3.2.1.86) COG2723 Cluster_754186 V1026146 S NA 126R7 Cluster_560078 V1026148 ATM1 V ABC transporter COG5265 Cluster_458417 V1026150 LEUC map00290,map00660,map01100,map01110,map01210,map01230 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) COG0065 Cluster_870942 V1026151 S NA 0ZHU9 Cluster_792191 V1026154 MIP O Peptidyl-prolyl cis-trans isomerase COG0545 Cluster_792192 V1026156 map00230 K, T Metal Dependent Phosphohydrolase COG0317 Cluster_698532 V1026157 S NA 12CUH Cluster_458418 V1026158 NUOG map00190,map00910,map01100 C NADH dehydrogenase subunit g COG1034 Cluster_458419 V1026159 DSBD O Thiol disulfide interchange protein COG4232 Cluster_458420 V1026160 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG2812 Cluster_458421 V1026162 YICC map03010 S YicC domain protein COG1561 Cluster_458422 V1026165 CYDB map00190,map01100,map02020 C cytochrome d ubiquinol oxidase, subunit ii COG1294 Cluster_569265 V1026166 HMUO map00860,map04978 P Heme oxygenase COG5398 Cluster_458423 V1026169 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_720799 V1026170 S NA 0ZHU9 Cluster_539542 V1026172 AROQ map00400,map01051,map01100,map01110,map01230 E Catalyzes a trans-dehydration via an enolate intermediate (By similarity) COG0757 Cluster_620764 V1026173 map00984,map01100,map01120,map01220 S hydrolase 0YAG9 Cluster_458425 V1026174 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_460474 V1026176 MCPU map02020,map02030 S Methyl-accepting chemotaxis sensory transducer COG0840 Cluster_458426 V1026177 map00230,map00240,map01100,map03030,map03410,map03420,map03440 L POLAc COG0749 Cluster_458427 V1026181 FADE map00071,map00280,map00281,map00410,map00640,map00650,map00930,map01100,map01110,map01120,map03320 I acyl-CoA dehydrogenase COG1960 Cluster_531001 V1026182 DLD2 map00620,map00630,map01100,map01110,map01120 C FAD linked oxidase domain protein COG0277 Cluster_854709 V1026183 LUXS map00270,map05111 T Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) COG1854 Cluster_460475 V1026188 S Transposition protein 17B81@proNOG Cluster_566171 V1026190 S ABC spermidine putrescine transporter, inner membrane subunit 16TCP@proNOG Cluster_460476 V1026192 S Fusaric acid resistance protein family 11ZH9 Cluster_486792 V1026194 S recb family COG2251 Cluster_460477 V1026199 BMUL_1335 S Protein of unknown function (DUF1800) COG5267 Cluster_687880 V1261823 E Peptidase M1 membrane alanine aminopeptidase COG0308 Cluster_596333 V1261846 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_599822 V1261848 map00230,map01100,map01110 F AICARFT/IMPCHase bienzyme COG0138 Cluster_599825 V1261860 MNME S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 Cluster_599826 V1261861 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_599834 V1261885 NDH map00190 C NADH dehydrogenase COG1252 Cluster_599836 V1261888 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_599839 V1261893 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_599840 V1261895 HISD map00340,map01100,map01110,map01230 E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) COG0141 Cluster_599844 V1261904 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_603420 V1261917 ROCD map00330,map01100,map01110 E Acetylornithine aminotransferase COG4992 Cluster_607026 V1261952 CINA H competence damage-inducible protein COG1546 Cluster_607027 V1261961 YEEN K transcriptional regulatory protein COG0217 Cluster_614405 V1261963 SUCD map00020,map00640,map00660,map00720,map01100,map01110,map01120 C Succinyl-CoA ligase ADP-forming subunit alpha COG0074 Cluster_696076 V1261966 GCVP map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG1003 Cluster_603438 V1261970 GCVP map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG1003 Cluster_603439 V1261973 G major facilitator superfamily MFS_1 0ZNSM Cluster_607035 V1261979 T Serine threonine protein kinase with WD-40 repeats COG0515 Cluster_607036 V1261984 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_607038 V1261987 SUCA map00020,map00310,map00380,map01100,map01110,map01120 C 2-oxoglutarate dehydrogenase, E1 COG0567 Cluster_607045 V1261997 V abc transporter atp-binding protein COG1131 Cluster_607048 V1262001 S repeat-containing protein 0XP3K Cluster_610682 V1262013 BGLS map00500,map01100 G Glycoside hydrolase family 16 COG2273 Cluster_610685 V1262019 S NA 0XRN7 Cluster_705516 V1262038 ROCD map00330,map01100,map01110 E Aminotransferase COG4992 Cluster_610695 V1262045 ACSA map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120 I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) COG0365 Cluster_610704 V1262063 ENC_19120 C Aldo Keto reductase COG0667 Cluster_610706 V1262072 METF map00670,map00720,map01100,map01120 E Methylenetetrahydrofolate reductase COG0685 Cluster_610712 V1262085 S Patatin family COG1752 Cluster_614413 V1262086 YAHD S ankyrin repeat protein YahD COG0666 Cluster_614422 V1262108 TESB map00062,map01040,map01100,map01110 I acyl-CoA thioesterase COG1946 Cluster_614424 V1262110 YAHK map00010,map00561,map00930,map01100,map01110,map01120 C alcohol dehydrogenase COG1064 Cluster_618155 V1262112 ADHA map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120 C alcohol dehydrogenase COG1064 Cluster_614427 V1262117 FAS map00061,map00350,map00362,map00627,map00642,map00903,map01100,map01120 I synthase COG4982 Cluster_618160 V1262126 map00230,map01100,map01110 F AICARFT/IMPCHase bienzyme COG0138 Cluster_789413 V1262134 O PPIases accelerate the folding of proteins (By similarity) COG0652 Cluster_618163 V1262137 S surface protein 11NE4 Cluster_614432 V1262139 map00361,map00623,map00627,map01120 C, H Phenol 2-monooxygenase COG0654 Cluster_618166 V1262146 CTAA map00190,map00860,map01100,map01110,map02020 O Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) COG1612 Cluster_637177 V1262161 C Oxidoreductase, aldo keto reductase family protein COG0667 Cluster_762459 V1262180 MET17 map00270,map01100 E sulfhydrylase COG2873 Cluster_618189 V1262187 T WD-40 repeat 16RQP@proNOG Cluster_621804 V1262190 SERB map00260,map00680,map01100,map01120,map01230 E phosphoserine phosphatase COG3830 Cluster_621811 V1262203 ADD map00230,map01100,map05340 F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) COG1816 Cluster_653229 V1262207 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_621815 V1262210 LYS2 map00300,map00310,map01100,map01110,map01230 E saccharopine dehydrogenase COG1748 Cluster_621817 V1262212 NEMA map00633,map01120 C Nadh flavin oxidoreductase nadh oxidase COG1902 Cluster_621819 V1262219 MNTH P H( )-stimulated, divalent metal cation uptake system (By similarity) COG1914 Cluster_621823 V1262230 GLTB map00250,map00630,map00910,map01100,map01110,map01120,map01230 E Glutamate synthase COG0070 Cluster_625595 V1262250 UBIE map00130,map01100,map01110 H Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) COG2226 Cluster_625600 V1262257 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_625602 V1262259 ACNA map00020,map00300,map00630,map00720,map01100,map01110,map01120,map01210,map01230 C Aconitate hydratase COG1048 Cluster_625605 V1262264 map04112 M Sel1 domain protein repeat-containing protein COG0790 Cluster_625610 V1262270 O Peptidyl-prolyl cis-trans isomerase COG0545 Cluster_629295 V1262289 HISA map00340,map01100,map01110,map01230 E phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase COG0106 Cluster_641177 V1262292 RHLG S Short-chain dehydrogenase reductase SDR 1763H@proNOG Cluster_629297 V1262300 PSAA map02010 P ABC transporter COG0803 Cluster_629306 V1262315 PIP map00330 L Prolyl aminopeptidase COG0596 Cluster_633130 V1262326 ACSA map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120 I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) COG0365 Cluster_734877 V1262332 map00010,map00040,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00640,map00903,map01100,map01110,map01120 C Aldehyde dehydrogenase COG1012 Cluster_633136 V1262342 PEPP E peptidase, M24 COG0006 Cluster_633137 V1262346 K WD-40 repeat-containing protein 0XP3K Cluster_629319 V1262353 NUOD map00190,map00910,map01100 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) COG0649 Cluster_633144 V1262359 S Inherit from NOG: domain protein 18D01@proNOG Cluster_633145 V1262361 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_633148 V1262367 GLCD2 map00620,map00630,map01100,map01110,map01120 C FAD linked oxidase domain protein COG0277 Cluster_637180 V1262371 YBGG map00511 G hydrolase, family 38 COG0383 Cluster_633153 V1262382 Q Phytanoyl-CoA dioxygenase 0XUSH Cluster_637194 V1262407 PROB map00330,map01100,map01230 E Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) COG0263 Cluster_699355 V1262414 RFBB map00521,map00523,map01055,map01100,map01110 M dTDP-glucose 4-6-dehydratase COG1088 Cluster_637202 V1262422 T WD-40 repeat COG2319 Cluster_637203 V1262425 PYC map00020,map00620,map00720,map01100,map01120,map01230 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) COG1038 Cluster_637207 V1262438 map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I acyl-CoA dehydrogenase 16PN3@proNOG Cluster_641181 V1262439 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_637208 V1262440 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_641183 V1262448 PDHB map00010,map00020,map00280,map00620,map00650,map01100,map01110,map01120,map04066 C pyruvate dehydrogenase e1 component suBunit beta COG0022 Cluster_641184 V1262452 ACEB map00620,map00630,map01100,map01120 C Malate synthase COG2225 Cluster_721695 V1262455 TETA G Major facilitator superfamily MFS_1 16UMY@proNOG Cluster_641191 V1262468 DEAD map03018 L atp-dependent rna helicase COG0513 Cluster_641192 V1262472 LYSP E permease COG0833 Cluster_721696 V1262488 CSHB map03018 L ATP-dependent RNA helicase COG0513 Cluster_645048 V1262500 PTRA O peptidase COG1025 Cluster_645050 V1262504 GDH map00250,map00330,map00430,map00910,map01100 E Dehydrogenase COG2902 Cluster_641205 V1262505 TRPD map00400,map01100,map01110,map01230 E anthranilate phosphoribosyltransferase COG0547 Cluster_641206 V1262510 map00290,map00300,map00620,map01100,map01110,map01210,map01230 E Homocitrate synthase COG0119 Cluster_641207 V1262518 DEAD map03018 L atp-dependent rna helicase COG0513 Cluster_645069 V1262543 MAEA map00620,map00710,map01100,map01120,map02020 C NAD-dependent malic enzyme COG0281 Cluster_645072 V1262547 SNF L snf2 family COG0553 Cluster_649160 V1262555 PGM map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase (EC 5.4.2.2 COG0033 Cluster_645079 V1262563 EMRB P drug resistance transporter, emrb qaca 16PY9@proNOG Cluster_645083 V1262576 SENC S Electron transport protein SCO1 SenC COG1999 Cluster_645085 V1262583 NRDA map00230,map00240,map00480,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_649177 V1262601 I Endonuclease Exonuclease phosphatase COG3568 Cluster_649184 V1262616 T WD domain Cytochrome c family protein 16RQP@proNOG Cluster_649185 V1262618 DAPE map00300,map01100,map01120,map01230 E peptidase COG0624 Cluster_653230 V1262619 map00627,map00790,map01100,map01120,map02020 S type i phosphodiesterase nucleotide pyrophosphatase COG1524 Cluster_653234 V1262630 MMUM map00270,map01100,map01110 E Homocysteine s-methyltransferase COG2040 Cluster_653235 V1262631 S repeat-containing protein 0YBBK Cluster_653256 V1262667 LSFA O Alkyl hydroperoxide reductase Thiol specific antioxidant COG0450 Cluster_805316 V1262675 C Monooxygenase 0XNPZ Cluster_683454 V1262677 PETA map00190,map00910,map01100,map02020,map04260,map05010,map05012,map05016 C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) COG0723 Cluster_657360 V1262678 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_657364 V1262691 FDH map00630,map00680,map01100,map01120 C formate dehydrogenase COG1052 Cluster_657371 V1262708 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_657374 V1262712 S tetratricopeptide 0XQVJ Cluster_657378 V1262716 GAPA map00010,map01100,map01110,map01120,map01230,map04066,map05010 G Glyceraldehyde-3-phosphate dehydrogenase, type I COG0057 Cluster_657379 V1262717 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_657382 V1262720 YDJJ map00040,map00051,map01100 E Dehydrogenase COG1063 Cluster_661571 V1262750 SFCA map00620,map00710,map01100,map01120,map02020 C NAD-dependent malic enzyme COG0281 Cluster_661573 V1262755 PEPP E peptidase, M24 COG0006 Cluster_665784 V1262802 K WD-40 repeat-containing protein COG1409 Cluster_665785 V1262804 map00250,map00290,map00710,map01100,map01110,map01120,map01210,map01230 E Aminotransferase COG0436 Cluster_665789 V1262811 GDHA map00250,map00330,map00910,map01100 E Glutamate dehydrogenase COG0334 Cluster_665791 V1262815 HEXOKINASE map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map04066,map04910,map04930,map04973 G hexokinase COG5026 Cluster_661599 V1262817 HEMH map00860,map01100,map01110 H Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) COG0276 Cluster_665799 V1262833 NRDA map00230,map00240,map00480,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_670087 V1262857 PCNA map03013,map03018 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate COG0617 Cluster_670091 V1262862 Y2960 map04723 S Zn-dependent Hydrolase of the beta-lactamase COG2220 Cluster_670092 V1262865 map01053 Q Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) COG1020 Cluster_670100 V1262878 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_670108 V1262896 MT1438 map00930,map01120 P Monooxygenase COG2072 Cluster_674462 V1262915 HMP map05132 C Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) COG1018 Cluster_674464 V1262918 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_674473 V1262930 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_674480 V1262939 D, Z regulator of chromosome condensation, RCC1 COG5184 Cluster_678901 V1262971 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_728351 V1262974 BETB map00010,map00040,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00640,map00903,map01100,map01110,map01120 C Dehydrogenase COG1012 Cluster_678909 V1262987 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_678911 V1262989 APEB E M18 family aminopeptidase COG1362 Cluster_678913 V1262995 RLME J Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) COG0293 Cluster_683462 V1263018 S WD-40 repeat protein 0XP3K Cluster_683464 V1263023 BMUL_2972 S Conserved Protein COG1565 Cluster_683479 V1263050 S WD-40 repeat-containing protein 0ZW01 Cluster_683482 V1263056 LEUD map00290,map00300,map00660,map01100,map01110,map01210,map01230 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) COG0066 Cluster_683486 V1263060 ACNA map00020,map00300,map00630,map00720,map01100,map01110,map01120,map01210,map01230 C Aconitate hydratase COG1048 Cluster_683487 V1263061 SIR map00920,map01100,map01120 C Sulfite reductase COG0155 Cluster_683491 V1263068 HYUB map00330,map00480,map01100 E 5-oxoprolinase (ATP-hydrolyzing) COG0146 Cluster_687889 V1263090 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_687908 V1263118 SCLAV_3043 S Aminopeptidase COG2234 Cluster_687922 V1263144 ACNA map00020,map00300,map00630,map00720,map01100,map01110,map01120,map01210,map01230 C Aconitate hydratase COG1048 Cluster_687923 V1263154 GDHA map00250,map00330,map00471,map00910,map01100,map04964 E Glutamate dehydrogenase COG0334 Cluster_692373 V1263164 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_692378 V1263172 ATZF map00330,map00360,map00380,map00627,map00643,map00791,map00970,map01100,map01120 J Allophanate hydrolase COG0154 Cluster_692379 V1263173 LYSP E permease COG0833 Cluster_813334 V1263192 S NA 0ZE8A Cluster_674497 V1263193 BCELL_1025 L Integrase COG2801 Cluster_165360 V1263194 S NA 11HCX Cluster_122171 V1263196 DCM map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_168552 V1263199 H UBA THIF-type NAD FAD binding protein COG0476 Cluster_183004 V1263204 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_164506 V1263206 CLOSA_0730 V Hnh endonuclease COG1479 Cluster_189042 V1263207 ECORIM L Modification methylase EcoRI 0XPU0 Cluster_154475 V1263208 ECORIM L Modification methylase EcoRI 0XPU0 Cluster_74823 V1263210 S Bacteriophage peptidoglycan hydrolase 0ZNE8 Cluster_144986 V1263211 HSDS V restriction COG0732 Cluster_245184 V1263212 ECFA1 map02010 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates COG1122 Cluster_88581 V1263219 S NA 11S7H Cluster_455047 V1263236 S Helix-turn-helix 11HER Cluster_105817 V1263274 S Collagen triple helix repeat 0YHFV Cluster_455049 V1263277 S Phage prohead protease, HK97 family COG3740 Cluster_122172 V1263283 S NA 0YMVP Cluster_543215 V1263302 S NA 0ZHU9 Cluster_773824 V1263307 S NA 0ZHU9 Cluster_637216 V1263313 S VRR-NUC domain protein 0Z445 Cluster_497243 V1263316 S NA 0ZHU9 Cluster_696082 V1263318 S NA 0ZHU9 Cluster_520568 V1263332 S NA 0ZHU9 Cluster_614436 V1263335 S NA 0ZHU9 Cluster_589475 V1263348 S NA 0ZHU9 Cluster_621829 V1263365 S NA 0ZHU9 Cluster_696083 V1263367 S NA 0ZHU9 Cluster_517993 V1263396 S NA 0ZHU9 Cluster_755169 V1263405 S NA 0ZHU9 Cluster_531818 V1263430 LYC M glycoside hydrolase, family 25 11T0J Cluster_708600 V1263434 S NA 0ZHU9 Cluster_715143 V1263446 S NA 0ZHU9 Cluster_699365 V1263466 K TRANSCRIPTIONal 0XZZF Cluster_461040 V1263484 S NA 0ZHU9 Cluster_880191 V1263495 S NA 0ZHU9 Cluster_385953 V1263504 SP_1492 S cell wall surface anchor family protein 0YURI Cluster_427191 V1263516 S NA 0ZHU9 Cluster_801138 V1263555 S NA 0ZHU9 Cluster_801139 V1263560 S NA 0ZHU9 Cluster_560933 V1263568 S NA 0ZHU9 Cluster_692385 V1263597 S NA 0ZHU9 Cluster_876154 V1263616 S NA 0ZHU9 Cluster_872067 V1263618 S NA 0ZHU9 Cluster_828721 V1263675 S NA 0ZHU9 Cluster_813341 V1263728 S NA 0ZHU9 Cluster_502449 V1263735 S NA 0ZHU9 Cluster_618194 V1263766 S NA 0ZHU9 Cluster_813342 V1263774 S NA 11U0C Cluster_460478 V1026201 L Pfam:Transposase_7 COG4644 Cluster_460479 V1026202 L helicase domain protein COG4889 Cluster_460480 V1026203 SCLAV_5386 G transporter 16R1Z@proNOG Cluster_504198 V1026204 DKGB C 2,5-diketo-D-gluconate reductase B COG0656 Cluster_460481 V1026205 YIAO G transporter COG1638 Cluster_656191 V1026208 PRPB map00640 G Inherit from COG: methylisocitrate lyase COG2513 Cluster_462596 V1026210 SURB S G5 domain protein 0ZVV3 Cluster_462597 V1026213 K Transcriptional regulator 1767W@proNOG Cluster_812253 V1026219 PSPC S phage shock protein C, PspC COG1983 Cluster_562983 V1026220 BGLG K antiterminator COG3711 Cluster_460483 V1026221 U, W surface protein COG5295 Cluster_765336 V1026225 IMPC S type VI secretion protein, EvpB VC_A0108 family COG3517 Cluster_695161 V1026226 IMPB S Type VI secretion protein, VC_A0107 family COG3516 Cluster_677652 V1026227 S NA 0ZHU9 Cluster_462598 V1026228 LTRA L reverse transcriptase COG3344 Cluster_462599 V1026229 RC1_2786 L transposase COG5433 Cluster_819738 V1026230 MT0886 S NA 0XXMY Cluster_462601 V1026232 BMA1016 L transposase, IS204 IS1001 IS1096 IS1165 family protein COG3464 Cluster_575685 V1026233 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_912252 V1026234 RPLV map03010 J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) COG0091 Cluster_780128 V1026238 BMUL_5591 S NA 17UB9@proNOG Cluster_656192 V1026240 FLID map02040 N flagellar hook-associated COG1345 Cluster_609633 V1026241 YHHQ S Membrane COG1738 Cluster_588496 V1026242 P Monooxygenase COG2072 Cluster_464696 V1026248 S Pfam:DUF1994 0XRWZ Cluster_464697 V1026250 S Domain of unknown function (DUF2479) 0ZFAE Cluster_605956 V1026252 map00627,map01120 C oxidoreductase COG1018 Cluster_506684 V1026254 GREA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) COG0782 Cluster_506685 V1026255 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_462603 V1026256 U, W Pfam:YadA COG5295 Cluster_462604 V1026257 S NA 16WK4@proNOG Cluster_464698 V1026258 E peptidase, M20 COG0624 Cluster_464699 V1026260 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_462605 V1026261 RPSA map00900,map01100,map01110,map03010 J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) COG0539 Cluster_464700 V1026262 map02020 P Heavy metal efflux pump, CzcA COG3696 Cluster_464703 V1026270 YGCS G Major Facilitator superfamily 170IE@proNOG Cluster_464704 V1026271 CHLI map00860,map01100,map01110 H magnesium chelatase COG1240 Cluster_578780 V1026274 ALGI map00350,map00362,map00627,map00642,map00903,map01120 M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_464706 V1026276 G Major Facilitator COG0477 Cluster_569266 V1026278 YYDK K transcriptional regulator COG2188 Cluster_464708 V1026281 DIND S DNA-damage-inducible protein d 0XQQP Cluster_464709 V1026283 M RHS repeat-associated core domain protein COG3209 Cluster_591868 V1026286 FECE map02010 P ABC transporter, ATP-binding protein COG1120 Cluster_464710 V1026287 YBHK S UPF0052 protein COG0391 Cluster_464711 V1026289 NUOM map00190,map00910,map01100 C subunit m COG1008 Cluster_464712 V1026292 SCLAV_2230 V ABC, transporter COG0577 Cluster_464713 V1026294 FNT P nitrite transporter COG2116 Cluster_464714 V1026295 S NA 11MA7 Cluster_464715 V1026296 S AAA domain (dynein-related subfamily) COG0714 Cluster_464716 V1026298 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_466715 V1026301 S recb family COG2251 Cluster_466716 V1026302 MQO map00620 C malate dehydrogenase (quinone) COG0579 Cluster_466717 V1026306 S NA 0ZTYV Cluster_471007 V1026308 UBIF map00130,map00340,map00361,map00363,map00623,map00624,map00626,map00627,map00903,map00945,map01100,map01110,map01120 C, H ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family COG0654 Cluster_605957 V1026310 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_466718 V1026311 S Protein of unknown function (DUF1524) COG1479 Cluster_595281 V1026313 map00300,map00550,map01100 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) COG0770 Cluster_464717 V1026314 QUEE map00790,map01100 H Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) COG0602 Cluster_562984 V1026315 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_466719 V1026318 EAEH map05100 S K13735 adhesin invasin 16SKU@proNOG Cluster_466720 V1026320 ACEA map00630,map01100,map01120 C Isocitrate lyase COG2224 Cluster_591869 V1026321 map05111 K LysR family Transcriptional regulator 16S2W@proNOG Cluster_750748 V1026323 S Caudovirus prohead protease 12923 Cluster_792193 V1026325 UGD map00040,map00053,map00500,map00520,map01100,map01110 M UDP-glucose 6-dehydrogenase COG1004 Cluster_514536 V1026327 FIC D cell filamentation protein COG2184 Cluster_466722 V1026328 CZCS map02020 T heavy metal sensor signal transduction histidine kinase COG0642 Cluster_780131 V1026329 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_780132 V1026330 INFA J however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) COG0361 Cluster_677654 V1026331 TESA map01040 E acyl-CoA thioesterase i COG2755 Cluster_839043 V1026332 YBBA map02010 Q (ABC) transporter COG4181 Cluster_466724 V1026336 FADD2 Q Acyl-CoA synthetase COG0318 Cluster_639997 V1026339 S intracellular protease Pfpi family COG0693 Cluster_468903 V1026343 BIGA S surface-exposed virulence protein 16QX6@proNOG Cluster_895429 V1026344 S NA 11ZSB Cluster_466726 V1026351 U TraG family COG3505 Cluster_468904 V1026353 S Band 7 protein COG2268 Cluster_468905 V1026354 UDGA map00040,map00053,map00500,map00520,map01100,map01110 M Udp-glucose 6-dehydrogenase COG1004 Cluster_468907 V1026357 O Antioxidant, AhpC TSA family 0ZMYB Cluster_677655 V1026360 ULAB map00053,map01100,map01120,map02060 G The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport COG3414 Cluster_867079 V1026361 ULAC map00051,map00053,map01100,map01120,map02060 G IIa component COG1762 Cluster_468908 V1026362 TREZ map00500,map01100,map01110 G maltooligosyl trehalose trehalohydrolase COG0296 Cluster_466727 V1026363 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_468909 V1026366 S Conserved Protein COG4804 Cluster_533775 V1026367 S Signal peptide 174BW@proNOG Cluster_499216 V1026368 Q isochorismatase COG1335 Cluster_588497 V1026369 ATPI C atp synthase 17PRS@proNOG Cluster_468910 V1026373 TREY map00500,map01100,map01110 G malto-oligosyltrehalose synthase COG3280 Cluster_578782 V1026375 SITA map02010,map02020 P periplasmic solute binding protein COG0803 Cluster_468911 V1026376 map00510,map01100 M glycosyltransferase, group 2 family protein COG0463 Cluster_468912 V1026377 U ABC transport system, lipoprotein 0XPU6 Cluster_569267 V1026378 BMUR_1701 L DNA mismatch repair protein 0XQSW Cluster_517260 V1026379 S NA 16WJ2@proNOG Cluster_643914 V1026382 MT1149 S Antibiotic biosynthesis monooxygenase COG1359 Cluster_468913 V1026383 PQIB S Mammalian cell entry related domain protein COG3008 Cluster_468914 V1026384 S NA 0YY2Z Cluster_468915 V1026386 AAS map00071,map00564 G Major Facilitator superfamily COG0318 Cluster_468916 V1026387 OMPB map02020 T Histidine kinase 1770R@proNOG Cluster_613288 V1026388 HMP map05132 C nitric oxide dioxygenase (EC 1.14.12.17) COG1018 Cluster_468917 V1026393 PTSP map00051,map01100,map02060 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) COG1080 Cluster_664549 V1026394 S fimbrial biogenesis protein 17BUV@proNOG Cluster_812255 V1026395 U NA 17SNS@proNOG Cluster_765339 V1026397 INSD L Transposase 174CV@proNOG Cluster_637218 V1263858 S NA 0ZHU9 Cluster_793207 V1263862 S NA 0ZHU9 Cluster_797187 V1263877 S NA 0ZHU9 Cluster_614441 V1263900 S NA 0ZHU9 Cluster_848191 V1263932 S NA 0ZHU9 Cluster_805327 V1263935 S NA 0ZHU9 Cluster_625623 V1263962 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_817097 V1263974 S NA 0ZHU9 Cluster_645092 V1263992 S NA 0ZHU9 Cluster_645093 V1263994 META map00270,map00920,map01100,map01110,map01230 E Homoserine O-transsuccinylase COG1897 Cluster_661603 V1264027 FTSI map00550,map01100 M penicillin-binding protein COG0768 Cluster_751699 V1264041 S NA 0ZHU9 Cluster_674502 V1264045 VIRE L Virulence-associated protein e COG5545 Cluster_233732 V1264073 PRMA J Methylates ribosomal protein L11 (By similarity) COG2264 Cluster_832493 V1264115 S NA 127RR Cluster_789427 V1264190 S NA 0ZHU9 Cluster_504854 V1264196 S NA 0ZHU9 Cluster_751700 V1264227 S NA 0ZHU9 Cluster_570197 V1264249 S NA 0ZHU9 Cluster_633165 V1264260 S NA 0ZHU9 Cluster_702423 V1264282 S NA 0ZHU9 Cluster_793213 V1264289 S NA 0ZHU9 Cluster_880210 V1264293 S NA 0ZHU9 Cluster_718396 V1264295 S NA 0ZHU9 Cluster_766426 V1264318 S NA 0ZHU9 Cluster_665814 V1264325 S NA 0ZHU9 Cluster_696090 V1264363 S NA 0ZHU9 Cluster_373637 V1264364 map02010 M Substrate binding domain of ABC-type glycine betaine transport system COG1732 Cluster_708605 V1264375 S NA 0ZHU9 Cluster_427193 V1264422 S NA 0ZHU9 Cluster_813350 V1264446 S NA 17D58@proNOG Cluster_824921 V1264448 S NA 0ZHU9 Cluster_797194 V1264483 S NA 17D58@proNOG Cluster_832501 V1264490 S NA 0ZHU9 Cluster_832504 V1264544 S NA 0ZHU9 Cluster_482788 V1264565 FBPA K Fibronectin-binding protein COG1293 Cluster_596344 V1264586 S NA 0ZHU9 Cluster_715153 V1264640 S NA 0ZHU9 Cluster_512611 V1264643 S NA 0ZHU9 Cluster_678936 V1264657 S NA 0ZHU9 Cluster_592880 V1264686 S NA 0ZHU9 Cluster_766432 V1264727 S NA 0ZHU9 Cluster_741620 V1264755 S NA 17D58@proNOG Cluster_855766 V1264776 S NA 0ZHU9 Cluster_731653 V1264792 S NA 0ZHU9 Cluster_692389 V1264859 S NA 0ZHU9 Cluster_653270 V1264905 S NA 0ZHU9 Cluster_670121 V1264968 S NA 0ZHU9 Cluster_106428 V1265013 S NA 0ZT45 Cluster_59350 V1265014 BL01171 P hemerythrin hhe cation binding domain protein COG2461 Cluster_180352 V1265016 YNAI M Mechanosensitive ion channel COG0668 Cluster_36146 V1265017 NADE map00760,map01100 H Nad synthetase COG0388 Cluster_42957 V1265018 S Inherit from NOG: Histidine triad protein 11G35 Cluster_60397 V1265019 S ATPase (AAA COG2607 Cluster_96827 V1265021 L Site-specific recombinase COG1961 Cluster_189906 V1265024 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG0582 Cluster_2235 V1265026 S NA 101UU Cluster_365369 V1265027 S Cell wall-associated COG3863 Cluster_56768 V1265033 SFUM_3007 map05100 M Repeat protein COG4886 Cluster_35173 V1265034 NANB map00511,map00600,map04142 G sialidase B COG4409 Cluster_75171 V1265036 STP T Phosphatase COG0631 Cluster_507432 V1265038 HSDM V type I restriction-modification system COG0286 Cluster_114229 V1265039 GATC2 map00052,map01100,map02060 G PTS system, galactitol-specific IIc component COG3775 Cluster_119145 V1265040 V Inherit from COG: restriction endodeoxyribonuclease activity COG1401 Cluster_368684 V1265041 S NA 11SYG Cluster_43710 V1265042 PEPD E Dipeptidase COG4690 Cluster_8253 V1265043 YLBB V abc transporter permease protein COG0577 Cluster_92825 V1265046 YLBM S UPF0348 protein COG1323 Cluster_94175 V1265047 S NA 0YBPX Cluster_11282 V1265049 M domain protein COG4932 Cluster_243908 V1265050 RFBD map00521,map00523,map01100,map01110 M Dtdp-4-dehydrorhamnose reductase COG1091 Cluster_163711 V1265051 MDT(A) G Major Facilitator COG0477 Cluster_130363 V1265052 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_2832 V1265053 L DNA helicase COG1112 Cluster_80977 V1265054 MURF map00300,map00550,map01100 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) COG0770 Cluster_441058 V1265055 S Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) 0XTXX Cluster_228955 V1265057 PIP map00330 E Proline imino-peptidase 0XPKQ Cluster_264380 V1265059 GG9_0942 L transposase COG2801 Cluster_87695 V1265060 S NA 0YUXA Cluster_7061 V1265063 K TRANSCRIPTIONal 11ZCE Cluster_313789 V1265064 S NA 0YSBV Cluster_319958 V1265065 BAS0367 map02010 P Binding-protein-dependent transport systems, inner membrane component COG0600 Cluster_89980 V1265066 TRPE map00400,map01100,map01110,map01230 E, H Anthranilate synthase component I, N terminal region COG0147 Cluster_259088 V1265067 S Protein of unknown function (DUF1624) COG3503 Cluster_453025 V1265070 S NA 0XYZV Cluster_62382 V1265072 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_69941 V1265073 YJHA S Endonuclease Exonuclease phosphatase 0XNVA Cluster_54541 V1265074 G carbohydrate kinase, YjeF related protein COG0062 Cluster_58046 V1265075 YPWA E carboxy-peptidase COG2317 Cluster_144987 V1265076 HEMN map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_13733 V1265077 L Helicase COG4581 Cluster_70897 V1265078 S domain protein 0YF83 Cluster_166169 V1265080 G Major Facilitator COG2814 Cluster_1179 V1265081 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_427194 V1265082 S Inherit from COG: ATPase (AAA COG1373 Cluster_82549 V1265083 L endonuclease I COG2356 Cluster_54757 V1265085 PEPD E Dipeptidase COG4690 Cluster_5416 V1265086 S NA 0YZ82 Cluster_313790 V1265087 MUTT map00230 F Nudix family COG1051 Cluster_271086 V1265088 SIGB K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG1191 Cluster_6732 V1265089 RECG map03420,map03440 L transcription-repair coupling factor COG1197 Cluster_255239 V1265090 MUTY map03410 L a g-specific adenine glycosylase COG1194 Cluster_378908 V1265091 S NA 0YQGS Cluster_173731 V1265092 PEPQ map00310,map00780,map01100 E peptidase M24 COG0006 Cluster_373638 V1265093 S Membrane 11U5A Cluster_175360 V1265094 E peptidase COG2195 Cluster_251560 V1265095 map02010 E Amino acid ABC transporter (Permease) COG0559 Cluster_168553 V1265096 map02010 E extracellular ligand-binding receptor COG0683 Cluster_212724 V1265097 map00860,map01100,map01110 S decarboxylase 11UPA Cluster_306596 V1265098 map00030,map00650,map01120 S Short-chain dehydrogenase reductase Sdr 0XNUN Cluster_89066 V1265100 S Inherit from NOG: LPXTG-motif cell wall anchor domain protein 0YEBJ Cluster_14815 V1265101 S NA 11QNK Cluster_62907 V1265103 S NA 0YDZN Cluster_9602 V1265104 U, W Domain-Containing protein COG5295 Cluster_224363 V1265105 YQHQ J Metal-dependent enzyme COG3872 Cluster_370384 V1265106 FSAB map00030,map01100,map01110,map01120,map01230 G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) COG0176 Cluster_300882 V1265107 map03060,map03070 U sec-independent protein 0ZXQT Cluster_26032 V1265109 CIRA P Receptor COG4771 Cluster_50959 V1265110 V ABC transporter COG1132 Cluster_3874 V1265113 S NA 0YG6V Cluster_152901 V1265114 DXR map00900,map01100,map01110 I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) COG0743 Cluster_64849 V1265115 P Chloride channel COG0038 Cluster_78790 V1265116 RNY S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 Cluster_65400 V1265119 YUXL E Acetyl xylan esterase (AXE1) COG1506 Cluster_231300 V1265122 M polysaccharide deacetylase COG0726 Cluster_227792 V1265125 TRXB map00240,map00450 O thioredoxin reductase COG0492 Cluster_200915 V1265126 map03430 L dna adenine COG0338 Cluster_144239 V1265127 BL01661 map05146 O proteinase inhibitor I4 serpin COG4826 Cluster_63184 V1265128 L Integrase 0YTFQ Cluster_560935 V1265129 S Polyketide cyclase / dehydrase and lipid transport 11UPQ Cluster_412568 V1265130 YDEA S ThiJ pfpI COG0693 Cluster_189043 V1265131 S NA 11QX6 Cluster_702427 V1265132 L DNA binding domain protein 11TH0 Cluster_423452 V1265133 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_461042 V1265134 S Addiction module antitoxin, RelB DinJ family 11X3K Cluster_287371 V1265135 HYCI O hydrogenase 3 maturation protease COG0680 Cluster_210506 V1265137 S NA 11UYY Cluster_809373 V1265138 S NA 121PH Cluster_665818 V1265139 S toxin-antitoxin system, antitoxin component, ribbon-helix-helix 11U5W Cluster_268436 V1265140 MSRA S methionine sulfoxide reductase A 0YJ5R Cluster_174550 V1265141 C NADH flavin oxidoreductase NADH oxidase COG1902 Cluster_801158 V1265142 K HTH_XRE 123HS Cluster_350621 V1265144 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_135082 V1265145 GSIA map02010 E, P ABC transporter COG0444 Cluster_396618 V1265146 K Transcriptional regulator, TetR family 103AX Cluster_169481 V1265147 S ThiF family 0XYAA Cluster_246515 V1265148 S NA 0ZFND Cluster_238641 V1265149 SCLAV_4279 map02010 V ABC transporter COG1131 Cluster_332087 V1265150 map02010 S transporter 11KUD Cluster_163712 V1265151 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_67898 V1265152 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_2778 V1265153 YXCA I coA-substrate-specific enzyme activase COG3581 Cluster_122173 V1265156 S Conjugative transposon TraM protein 11JMY Cluster_12998 V1265157 S conjugation system ATPase, TraG family 0XSHU Cluster_82550 V1265159 SCLAV_1000 S TPR-repeat-containing protein 10GX4 Cluster_14978 V1265160 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_45957 V1265161 S NA 0YBPX Cluster_298220 V1265162 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_272422 V1265163 ATPB map00190,map00195,map01100 C it plays a direct role in the translocation of protons across the membrane (By similarity) COG0356 Cluster_28570 V1265165 RECG map03440 L ATP-dependent DNA helicase RecG COG1200 Cluster_224364 V1265166 TRPC map00400,map01100,map01110,map01230 E Indole-3-glycerol phosphate synthase COG0134 Cluster_83014 V1265169 GATA map00970,map01100 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) COG0154 Cluster_27467 V1265170 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG2812 Cluster_269782 V1265172 P Binding-protein-dependent transport systems inner membrane component COG0601 Cluster_234922 V1265173 S NA 122YS Cluster_54542 V1265174 V type I restriction-modification COG0286 Cluster_77136 V1265175 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_95716 V1265176 map00730,map01100 H IA, variant 3 COG0637 Cluster_226652 V1265178 S integral membrane protein 0XS1S Cluster_45177 V1265185 S SpoIVB peptidase S55 0ZD6H Cluster_375351 V1265186 K RNA polymerase sigma 11Q7Q Cluster_152902 V1265187 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_14130 V1265188 L Helicase COG4581 Cluster_40547 V1265189 B, K histone acetyltransferase COG1243 Cluster_135893 V1265191 HIPO map00360 E amidohydrolase COG1473 Cluster_157839 V1265192 METN map02010 P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COG1135 Cluster_272423 V1265193 map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01230 G fructose-bisphosphate aldolase COG0191 Cluster_17888 V1265194 S fibronectin type III domain protein 11FT5 Cluster_177811 V1265195 GALE map00052,map00520,map01100,map01110 M udp-glucose 4-epimerase COG1087 Cluster_629328 V1265196 S NA 11PQ1 Cluster_66862 V1265197 CMK map00240,map00410,map00770,map01100,map01110 F Cytidine monophosphate kinase COG0283 Cluster_48768 V1265198 GATB map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 Cluster_56511 V1265200 MOD L DNA methylase COG2189 Cluster_101156 V1265201 M glycosyl transferase group 1 0ZVDW Cluster_785431 V1265202 CBIO2 map02010 P abc transporter COG1122 Cluster_276433 V1265203 CBIO2 map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_81759 V1265204 P Sulfatase COG3119 Cluster_217360 V1265206 G Sugar (and other) transporter 172C0@proNOG Cluster_220840 V1265208 G Binding-protein-dependent transport systems, inner membrane component COG4209 Cluster_37647 V1265210 S tonB-dependent Receptor 0Y4TD Cluster_7575 V1265211 O cysteine protease COG4870 Cluster_6666 V1265214 S Inherit from NOG: Mediates binding to human platelets, possibly through a receptor-ligand interaction. Probably associated with virulence in endovascular infection (By similarity) 12CMI Cluster_227793 V1265215 AGUB map00330,map01100 S hydrolase, carbon-nitrogen family COG0388 Cluster_181171 V1265217 C formate dehydrogenase 11QFX Cluster_40712 V1265220 map02010 V ABC transporter COG1132 Cluster_218497 V1265221 PYRB map00240,map00250,map01100 F aspartate transcarbamylase COG0540 Cluster_31413 V1265222 S NA 11YT1 Cluster_104614 V1265224 PURB map00230,map00250,map01100,map01110 F Adenylosuccinate lyase COG0015 Cluster_221998 V1265225 MAZG map00230,map00240,map01100 S MazG family COG3956 Cluster_53517 V1265226 COMEC S DNA internalization-related competence protein ComEC Rec2 COG2333 Cluster_211631 V1265227 S Outer surface protein COG3589 Cluster_20379 V1265229 M Export protein COG1596 Cluster_203992 V1265230 S DNA-binding protein COG3943 Cluster_45178 V1265231 V ATPase associated with various cellular activities aaa_5 COG1401 Cluster_211632 V1265232 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_27275 V1265235 CIRA P Receptor COG4771 Cluster_98977 V1265236 PEPDA E Dipeptidase COG4690 Cluster_410752 V1265237 L site-specific recombinase, phage integrase family 0ZJK4 Cluster_112059 V1265238 L helicase COG4646 Cluster_254034 V1265239 S Nucleotidyl transferase of unknown function (DUF1814) 0XPMU Cluster_674510 V1265240 L DNA binding protein, excisionase family 0YKT7 Cluster_41841 V1265241 V ATPase associated with various cellular activities aaa_5 COG1401 Cluster_28070 V1265242 S Protein of unknown function (DUF524) COG1700 Cluster_48769 V1265244 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_14454 V1265246 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_665819 V1265247 PIPD E Dipeptidase COG4690 Cluster_246516 V1265248 YITL S S1 RNA binding domain protein COG2996 Cluster_185582 V1265250 V ABC, transporter COG0577 Cluster_114230 V1265258 M Alpha beta hydrolase fold COG1073 Cluster_198916 V1265259 ISPB map00900,map01110 H synthase COG0142 Cluster_741622 V1265260 CZCD P cation diffusion facilitator family transporter COG0053 Cluster_148102 V1265261 S NA 11QZ9 Cluster_419803 V1265269 DCD map00240,map01100 F deoxycytidine triphosphate deaminase COG0717 Cluster_191684 V1265270 GAP map00010,map01100,map01110,map01120,map01230,map04066,map05010 G Glyceraldehyde-3-phosphate dehydrogenase, type I COG0057 Cluster_6667 V1265271 S NA 0XXUU Cluster_485117 V1265273 S Domain of unknown function (DUF1896) 0YBI2 Cluster_653273 V1265274 MIDI_00056 L Transposase 0YEAS Cluster_345791 V1265275 S TIGR02453 family COG5587 Cluster_738226 V1265276 S NA 12BJS Cluster_155307 V1265279 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_540288 V1265280 V Type I restriction enzyme R protein N terminus (HSDR_N) COG0610 Cluster_88130 V1265281 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_110066 V1265282 S atpase, aaa COG1373 Cluster_330535 V1265283 S NA 11XST Cluster_1941 V1265285 S NA 0YZ82 Cluster_71520 V1265286 GPMI map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0696 Cluster_125422 V1265287 S NA 0Z31Z Cluster_45004 V1265289 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG2812 Cluster_285974 V1265290 M Putative cell wall binding repeat 2 COG2247 Cluster_5977 V1265291 S Cell surface protein 0ZXQA Cluster_131140 V1265292 U, W domain protein COG5295 Cluster_128200 V1265294 H Molybdenum cofactor synthesis domain protein COG0303 Cluster_22800 V1265295 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_478060 V1265298 QUEF map00790,map01100 S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) COG0780 Cluster_208384 V1265300 map00627,map00740,map01120,map05152 S Phosphatase COG1409 Cluster_15407 V1265301 P tonB-dependent Receptor 0XNN9 Cluster_20546 V1265302 P tonB-dependent Receptor 0XQJQ Cluster_233733 V1265303 map00627,map00740,map01120,map05152 S Phosphatase COG1409 Cluster_19292 V1265304 map00500,map01100,map01110 G, M phosphorylase COG0438 Cluster_27468 V1265305 N Cell surface protein 0XQ7Y Cluster_186502 V1265307 V abc transporter COG1131 Cluster_1770 V1265308 L helicase COG4646 Cluster_36876 V1265309 L DNA Methylase COG2189 Cluster_281740 V1265310 S Abortive infection protein AbiGII 0XQHH Cluster_416217 V1265311 S Abortive infection protein AbiGI 11WH3 Cluster_190763 V1265313 L exonuclease 0ZWN0 Cluster_144240 V1265314 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_271087 V1265315 YUT E UreA transporter COG4413 Cluster_19209 V1265316 S peptidase C10 11SDT Cluster_72166 V1265317 S NA 0YX7E Cluster_427195 V1265318 O AhpC TSA family COG0526 Cluster_201900 V1265319 TRAG2 S conjugation system ATPase, TraG family 0XSHU Cluster_637221 V1265320 TRAF2 S conjugative transposon protein TraF 0YJGM Cluster_683512 V1265321 TRAE S conjugative transposon protein TraE 11QVH Cluster_44665 V1265322 PLC map00562 S Phosphatidylinositol-specific phospholipase C 0ZKFY Cluster_122846 V1265323 S NA 0Z34Z Cluster_451095 V1265324 CCAN_12780 L Transposase COG1662 Cluster_15321 V1265325 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_6185 V1265326 S Pfam:YadA 126HB Cluster_139796 V1265327 GLF M udp-galactopyranose mutase COG0562 Cluster_347391 V1265334 LYC M glycoside hydrolase, family 25 11T0J Cluster_261705 V1265339 S NA 0Z7V2 Cluster_277741 V1265341 S NA 124TY Cluster_17889 V1265342 S NA 0YZ82 Cluster_22202 V1265343 S NA 0YZ82 Cluster_260396 V1265347 S Tetratricopeptide repeat protein 0XUD3 Cluster_357155 V1265349 S NA 0YYM2 Cluster_398352 V1265350 K Transcriptional regulator, ARAC family 11PBK Cluster_259089 V1265351 S YitT family COG1284 Cluster_12029 V1265352 S NA 0Z9FI Cluster_560937 V1265354 S NA 11WDF Cluster_172907 V1265355 V type I restriction modification DNA specificity domain COG0732 Cluster_339604 V1265356 MELS_0665 L Reverse transcriptase (RNA-dependent DNA polymerase) COG3344 Cluster_145736 V1265357 GALK map00052,map00520,map01100,map01110 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) COG0153 Cluster_5687 V1265360 S NA 11YT1 Cluster_53287 V1265362 S F5/8 type C domain 12CZN Cluster_75472 V1265364 map03440 K Divergent AAA domain protein COG2865 Cluster_789438 V1265365 K Transcriptional regulator 121UZ Cluster_607063 V1265366 V restriction 0XT7W Cluster_300883 V1265367 YLME F alanine racemase domain protein COG0325 Cluster_81760 V1265368 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_13420 V1265371 S NA 11QZ9 Cluster_127510 V1265372 CKL_1893 S Phage replisome organizer 11V35 Cluster_53518 V1265373 M Cell wall anchor domain protein 11Q8J Cluster_140531 V1265374 S NA 11HCX Cluster_494735 V1265375 S MTH538 TIR-like domain (DUF1863) 11U1P Cluster_70898 V1265377 HTRA map02020 O protease COG0265 Cluster_98444 V1265393 ASPA map00250,map00910,map01100 E Aspartate ammonia-lyase COG1027 Cluster_22357 V1265394 S NA 0XSI9 Cluster_134290 V1265395 PORAS_0418 L reverse transcriptase COG3344 Cluster_696100 V1265396 L NA 0YKV1 Cluster_127511 V1265398 S Virulence-associated protein e COG5545 Cluster_184711 V1265399 S NA 0XTEF Cluster_517995 V1265400 S Protein of unknown function (DUF3408) 11QAR Cluster_193508 V1265401 S relaxase mobilization nuclease domain protein 0XNXG Cluster_63755 V1265403 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_64290 V1265404 YBIP S Sulfatase COG2194 Cluster_96828 V1265406 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_469441 V1265408 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_22203 V1265410 S NA 11QZ9 Cluster_322998 V1265411 VEX1 V ABC transporter, permease COG0577 Cluster_625628 V1265412 HSDR V Type I Restriction COG0610 Cluster_7838 V1265415 DING map00230,map00240,map01100,map03030,map03430,map03440 L helicase COG2176 Cluster_2855 V1265417 S NA 11MTE Cluster_515329 V1265418 S NA 11UWB Cluster_447098 V1265419 COMF map00230,map00250,map01100,map01110 S Competence protein COG1040 Cluster_6205 V1265420 P TonB-dependent Receptor Plug 0XNNV Cluster_400078 V1265422 S FMN_bind 12BR0 Cluster_373640 V1265423 S NA 11X7Q Cluster_7213 V1265424 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_696101 V1265426 S Toxin-antitoxin system, toxin component, RelE family 122S4 Cluster_44666 V1265427 S YD repeat protein 0Z0FY Cluster_24363 V1265428 M YD repeat protein COG3209 Cluster_25602 V1265430 M YD repeat protein COG3209 Cluster_8626 V1265432 P TonB-dependent receptor Plug 0XNPQ Cluster_781340 V1265435 M YD repeat protein COG3209 Cluster_7263 V1265438 S NA 0ZTYV Cluster_247772 V1265440 S NA 0YVMU Cluster_715156 V1265441 V ABC transporter transmembrane region COG1132 Cluster_48323 V1265446 N Cell surface protein 1CAVF@tenNOG Cluster_302259 V1265447 YEEA V methylase COG1002 Cluster_294066 V1265448 FAHA Q 5-carboxymethyl-2-hydroxymuconate Delta-isomerase (EC 5.3.3.10) COG0179 Cluster_298221 V1265449 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_8427 V1265451 S NA 0ZTYV Cluster_31414 V1265453 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii subunits gamma and tau COG2812 Cluster_196986 V1265454 S Domain of unknown function (DUF1848) 0XPNI Cluster_179519 V1265456 S Viral (Superfamily 1) RNA helicase 11I99 Cluster_288737 V1265457 S NA 0YT0E Cluster_148842 V1265458 L Integrase COG4974 Cluster_661606 V1265460 S Membrane 11UEJ Cluster_34507 V1265461 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii subunits gamma and tau COG2812 Cluster_46929 V1265462 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_692391 V1265463 S Membrane 12424 Cluster_137493 V1265465 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_39485 V1265466 S M6 family metalloprotease domain protein 0XTK2 Cluster_80590 V1265468 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_407128 V1265470 RESD map02020 T Response regulator receiver domain protein COG0745 Cluster_9603 V1265474 S Inherit from COG: leucine Rich Repeat COG4886 Cluster_152066 V1265476 FCL map00051,map00520,map01100 M Nad-dependent epimerase dehydratase COG0451 Cluster_363624 V1265477 S Plasmid pRiA4b ORF-3 family protein 11TVE Cluster_49588 V1265478 GLTD map00250,map00910,map01100,map01110,map01120,map01230 C, E pyridine nucleotide-disulfide oxidoreductase COG1894 Cluster_2032 V1265479 S NA 0YZ82 Cluster_318476 V1265482 INSI L transposase COG2826 Cluster_196169 V1265483 M glycosyl transferase group 1 17NBC@proNOG Cluster_13965 V1265484 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_174551 V1265485 S NA 0XNWW Cluster_102272 V1265486 SPMB S nucleoside recognition domain protein COG2715 Cluster_6346 V1265487 map00051,map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 G ec 3.2.1.52 COG3525 Cluster_75792 V1265489 S NA 0ZDF1 Cluster_36002 V1265490 IRP P tonB-dependent Receptor COG1629 Cluster_74496 V1265492 PCCB map00280,map00630,map00640,map00720,map01100,map01120 I carboxyl transferase COG4799 Cluster_401857 V1265495 PNCA map00760,map01100 Q isochorismatase COG1335 Cluster_43711 V1265496 M Cell wall anchor domain protein 11Q8J Cluster_378909 V1265497 THIN map00730,map01100 H thiamine COG1564 Cluster_418015 V1265498 PNUC H Nicotinamide Mononucleotide Transporter COG3201 Cluster_167703 V1265501 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) COG0167 Cluster_11056 V1265502 U, W domain protein COG5295 Cluster_3039 V1265504 U, W Inherit from COG: domain protein COG5295 Cluster_12216 V1265505 U, W domain protein COG5295 Cluster_12527 V1265506 U, W domain protein COG5295 Cluster_319959 V1265507 map02010 E (ABC) transporter COG4608 Cluster_400079 V1265510 RECR map03440 L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) COG0353 Cluster_218498 V1265511 OPPD map02010 E, P ABC transporter COG0444 Cluster_425 V1265513 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_47294 V1265514 CYSG map00860,map01100,map01110 H Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) COG1587 Cluster_10263 V1265516 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_171168 V1265517 UGPC map02010 G abc transporter COG3839 Cluster_46930 V1265518 CYSG map00860,map01100,map01110 H Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) COG1587 Cluster_187341 V1265519 HEMC map00860,map01100,map01110 H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) COG0181 Cluster_17563 V1265520 GYRA2 L DNA topoisomerase IV subunit A COG0188 Cluster_30957 V1265521 U, W domain protein COG5295 Cluster_122847 V1265522 HTH_1030 map02020 T response regulator COG2204 Cluster_27095 V1265523 V ABC transporter, permease protein 0XP9H Cluster_534610 V1265525 S Inherit from NOG: Mediates binding to human platelets, possibly through a receptor-ligand interaction. Probably associated with virulence in endovascular infection (By similarity) 12CMI Cluster_35174 V1265526 U, W domain protein COG5295 Cluster_497245 V1265528 RNHA map03030 S Ribonuclease COG3341 Cluster_296827 V1265530 PYRK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) COG0543 Cluster_68225 V1265531 M Putative cell wall binding repeat 2 COG2247 Cluster_62383 V1265533 CYDC map02010 V ABC transporter COG1132 Cluster_28670 V1265535 S domain protein 0YF83 Cluster_3079 V1265536 P TonB-dependent Receptor Plug Domain protein COG4771 Cluster_363625 V1265537 L DNA alkylation repair enzyme COG4912 Cluster_76769 V1265538 SLGD_00064 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_793220 V1265539 TRPA map00260,map00400,map01100,map01110,map01230 E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) COG0159 Cluster_139014 V1265541 CSE4 L Crispr-associated protein, cse4 family 0Y6PV Cluster_375352 V1265542 CASE L crispr-associated protein 0XPHC Cluster_312292 V1265543 S vitamin B12 dependent methionine synthase activation 11H9C Cluster_257758 V1265544 YJHA S Endonuclease Exonuclease phosphatase 0XNVA Cluster_362057 V1265545 CIAR map02020 T response regulator COG0745 Cluster_21687 V1265548 S NA 0Y5B4 Cluster_400080 V1265549 OTER_1220 P bfd domain protein (2fe-2s)-binding domain protein COG2608 Cluster_31085 V1265550 S NA 0Y5B4 Cluster_592883 V1265551 S Protein of unknown function (DUF721) 12036 Cluster_77137 V1265552 SUFB O FeS assembly protein SUFB COG0719 Cluster_1172 V1265553 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_42958 V1265554 S NA 0ZHVH Cluster_19026 V1265555 THIC map00730,map01100 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) COG0422 Cluster_92826 V1265556 S NA 11FTA Cluster_101707 V1265557 S S-layer domain protein 11R54 Cluster_206158 V1265558 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_102807 V1265559 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_195316 V1265560 MENC map00130,map01100,map01110 M mandelate racemase muconate lactonizing COG4948 Cluster_159559 V1265561 V Restriction modification system DNA (Specificity COG0732 Cluster_7182 V1265563 S NA 0XS7F Cluster_8178 V1265564 S Inherit from NOG: antigen PG97 COG4886 Cluster_16735 V1265566 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_445049 V1265568 ATPF map00190,map00195,map01100 C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) COG0711 Cluster_6466 V1265570 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_85123 V1265571 S Lpxtg-motif cell wall anchor domain protein 0XQBH Cluster_24694 V1265572 S Inherit from NOG: Mediates binding to human platelets, possibly through a receptor-ligand interaction. Probably associated with virulence in endovascular infection (By similarity) 12CMI Cluster_184712 V1265573 map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_69619 V1265575 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Involved in acetate metabolism (By similarity) COG0280 Cluster_267024 V1265576 U MotA TolQ exbB proton channel COG0811 Cluster_247773 V1265578 FESA C Binding Domain protein 0XPB7 Cluster_345792 V1265579 TMK map00240,map01100 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) COG0125 Cluster_152903 V1265582 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_1875 V1265584 S NA 0YZ82 Cluster_403649 V1265586 V type I restriction enzyme 11IAT Cluster_330536 V1265589 ISCU C SUF system FeS assembly protein COG0822 Cluster_55994 V1265590 U, W Inherit from COG: domain protein COG5295 Cluster_81350 V1265591 S Inherit from NOG: DNA repair protein 0XQPN Cluster_8903 V1265594 S NA 12BGB Cluster_773840 V1265595 PGN_0614 S dNA-binding protein 0YMVW Cluster_445050 V1265596 ATPF map00190,map00195,map01100 C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) COG0711 Cluster_119908 V1265597 M YD repeat protein COG3209 Cluster_141285 V1265598 CKL_1893 S Phage replisome organizer 11V35 Cluster_13127 V1265599 S NA 0YG6V Cluster_95217 V1265600 SCLAV_1000 S TPR-repeat-containing protein 10GX4 Cluster_662 V1265601 U, W Pfam:HIM COG5295 Cluster_217361 V1265602 XERD L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_43712 V1265603 DEAD map03018 L dead deah box COG0513 Cluster_25803 V1265604 S NA 101UU Cluster_385954 V1265605 CRR map00010,map00500,map00520,map02060 G PTS System COG2190 Cluster_183828 V1265606 SP_0571 D Cell filamentation protein Fic-related protein COG2184 Cluster_281741 V1265607 S domain protein 0XNZW Cluster_494736 V1265608 S GtrA-like protein 12D1Q Cluster_641214 V1265610 RPLD map03010 J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) COG0088 Cluster_358807 V1265611 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_711783 V1265612 RPSS map03010 J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) COG0185 Cluster_7980 V1265614 S NA 0YZ82 Cluster_8495 V1265616 M YD repeat protein COG3209 Cluster_303706 V1265618 GPMA map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0588 Cluster_216166 V1265620 YDJZ S SNARE associated Golgi protein-related protein COG0398 Cluster_543219 V1265621 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_22530 V1265622 S NA 0YDZN Cluster_78413 V1265624 P hemerythrin hhe cation binding domain protein COG2461 Cluster_94707 V1265625 S iron-regulated transmembrane protein 11UNT Cluster_6544 V1265628 M domain protein COG4932 Cluster_183005 V1265630 DINB L Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) COG0389 Cluster_69271 V1265634 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_824938 V1265635 MIDI_00056 L Transposase 0YEAS Cluster_74191 V1265636 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_1215 V1265637 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_55995 V1265639 map02010 V abc transporter COG1132 Cluster_135083 V1265645 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_836367 V1265646 S Toxin-antitoxin system, toxin component, RelE family 122S4 Cluster_31616 V1265647 RECG map03440 L ATP-dependent DNA helicase RecG COG1200 Cluster_81351 V1265648 YLOV S dak2 domain fusion protein ylov COG1461 Cluster_1317 V1265650 S NA 11NI8 Cluster_674512 V1265652 CAS2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) COG3512 Cluster_4262 V1265653 CSN1 L crispr-associated protein COG3513 Cluster_1850 V1265656 S Rib/alpha-like repeat 0YK85 Cluster_65107 V1265657 CTPC map00190 P heavy metal translocating P-type ATPase COG2217 Cluster_1647 V1265659 S NA 0YG6V Cluster_480463 V1265661 DPS P ferritin dps family protein COG0783 Cluster_94708 V1265662 S S-layer domain protein 11R54 Cluster_277742 V1265664 map02010 P Cobalt transport protein COG0619 Cluster_546152 V1265665 map02010 P ABC transporter COG1122 Cluster_203993 V1265666 map02010 P ABC transporter COG1122 Cluster_102273 V1265672 F Amidohydrolase family COG0402 Cluster_86827 V1265673 AHCY map00270,map01100 H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) COG0499 Cluster_7099 V1265674 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_54037 V1265675 V abc transporter COG1132 Cluster_119146 V1265676 RNFC C Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) COG4656 Cluster_570198 V1265677 S conjugation system ATPase, TraG family 0XSHU Cluster_711784 V1265679 S NA 11W2F Cluster_62384 V1265680 TOPB L Dna topoisomerase COG0550 Cluster_238643 V1265681 YEEA V methylase COG1002 Cluster_142786 V1265682 NDVA2 V ABC transporter, ATP-binding protein COG1132 Cluster_2145 V1265683 U, W Pfam:HIM COG5295 Cluster_497246 V1265684 S NA 0YRVQ Cluster_96307 V1265685 S NA 0YDPS Cluster_586195 V1265686 S Membrane 11TU2 Cluster_16445 V1265687 S NA 0YG6V Cluster_54302 V1265689 M domain protein COG4932 Cluster_2527 V1265692 U, W Pfam:YadA COG5295 Cluster_41842 V1265693 V ABC transporter COG1132 Cluster_178653 V1265694 CSE4 L Crispr-associated protein, cse4 family 0Y6PV Cluster_324582 V1265695 CAS5E L crispr-associated protein 11JEJ Cluster_134291 V1265696 PGN_0948 S NA 0Z217 Cluster_546153 V1265697 S NA 0YIEB Cluster_124761 V1265698 L Integrase 0YTFQ Cluster_2885 V1265700 U, W Pfam:YadA COG5295 Cluster_6525 V1265701 U, W Inherit from COG: domain protein COG5295 Cluster_523316 V1265702 S Addiction module antitoxin, RelB DinJ family 0XUTM Cluster_755186 V1265703 S NA 127RR Cluster_191685 V1265704 BL02849 S Baat aCyl-coa thioester hydrolase COG1073 Cluster_554964 V1265705 YHGE S domain protein COG1511 Cluster_189907 V1265706 S ABC transporter 124C1 Cluster_112060 V1265707 S NA 0YSBI Cluster_400081 V1265708 ARGF map00330,map01100,map01110,map01230 E ornithine carbamoyltransferase COG0078 Cluster_357156 V1265709 S NA 0YZ82 Cluster_206159 V1265710 CHLI map00860,map01100,map01110 H magnesium chelatase COG1239 Cluster_20154 V1265711 CHLD map00860,map01100,map01110 H magnesium chelatase COG1240 Cluster_81761 V1265713 S S-layer domain protein 11R54 Cluster_3386 V1265714 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_14455 V1265716 M domain protein COG4932 Cluster_456983 V1265717 map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase family protein COG0406 Cluster_3500 V1265718 M domain protein COG4932 Cluster_45180 V1265720 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_653274 V1265721 L Integrase core domain protein COG2801 Cluster_728377 V1265722 S NA 11W2F Cluster_4737 V1265723 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_540289 V1265724 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_692392 V1265725 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_4548 V1265726 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_9701 V1265730 S NA 0YG6V Cluster_275108 V1265734 CYSE map00270,map00920,map01100,map01120,map01230 E serine acetyltransferase COG1045 Cluster_251562 V1265735 CYSK map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_291338 V1265736 S NA 11J85 Cluster_181172 V1265737 map02010 V abc transporter COG1131 Cluster_16446 V1265739 S NA 11QZ9 Cluster_16940 V1265742 S NA 0ZTYV Cluster_14929 V1265744 S NA 101UU Cluster_365370 V1265745 S NA 11JB6 Cluster_226653 V1265746 S NA 0ZUV9 Cluster_5744 V1265748 U, W Inherit from COG: domain protein COG5295 Cluster_350622 V1265749 RDGB map00230,map00240,map01100 F Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) COG0127 Cluster_55003 V1265750 M Cell wall binding repeat 2-containing protein COG2247 Cluster_180353 V1265752 L TatD-related deoxyribonuclease COG0084 Cluster_276434 V1265753 CBIO2 map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_280414 V1265754 map02010 P abc transporter COG1122 Cluster_60968 V1265755 AMS1 map00511 G hydrolase, family 38 COG0383 Cluster_164507 V1265758 V restriction enzyme 17CDW@proNOG Cluster_40868 V1265759 BCGIA V Type II restriction modification enzyme methyltransferase COG0286 Cluster_526220 V1265760 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_6545 V1265761 U, W Inherit from COG: domain protein COG5295 Cluster_170351 V1265762 V restriction enzyme 17CDW@proNOG Cluster_40869 V1265763 BCGIA V Type II restriction modification enzyme methyltransferase COG0286 Cluster_73525 V1265764 map05100 S NA 0XZM9 Cluster_219647 V1265767 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_23577 V1265768 M YD repeat protein COG3209 Cluster_8155 V1265770 S Cell surface protein 0ZXQA Cluster_653275 V1265771 S NA 127RR Cluster_163713 V1265772 PPX map00230 F, P ppx gppa phosphatase COG0248 Cluster_216167 V1265773 L Replication Protein COG5655 Cluster_185583 V1265774 S TPR repeat-containing protein COG0457 Cluster_348990 V1265775 map00361,map00625,map01100,map01120 S had-superfamily hydrolase, subfamily ia, variant COG1011 Cluster_255240 V1265776 S NA 0YQGS Cluster_552077 V1265777 S Nitroreductase COG3560 Cluster_12879 V1265778 S NA 126VW Cluster_168554 V1265782 L Integrase COG0582 Cluster_124762 V1265783 CYCMA_1561 L Transposase COG3436 Cluster_171993 V1265785 U, W domain protein COG5295 Cluster_103441 V1265786 K Inherit from COG: Transcriptional regulator COG2865 Cluster_637222 V1265788 S NA 0XWWF Cluster_576629 V1265789 S NA 0XWWF Cluster_298222 V1265790 AROD map00400,map01100,map01110,map01230 E Type I DHQase COG0710 Cluster_674513 V1265791 S NA 125ZN Cluster_738227 V1265792 K ParB-like COG1475 Cluster_13213 V1265793 S conserved domain protein 0YAQR Cluster_309329 V1265795 S NA 0YY56 Cluster_711785 V1265796 SP_0276 S addiction module toxin, RelE StbE family COG3041 Cluster_145737 V1265797 M Cell wall binding repeat 2-containing protein COG2247 Cluster_373641 V1265798 S integral membrane protein 0XS1S Cluster_11161 V1265799 BL01323 M Cell wall binding repeat 2-containing protein 0ZKZU Cluster_17635 V1265800 S NA 0YG6V Cluster_468918 V1026401 PRPD map00640 S 2-methylcitrate dehydratase COG2079 Cluster_471008 V1026407 V ABC transporter, ATP-binding protein COG1132 Cluster_784375 V1026408 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_769189 V1026414 S NA 0ZHU9 Cluster_647928 V1026416 MTBA G Transporter 16QT5@proNOG Cluster_595282 V1026418 CZCC M Outer membrane efflux protein COG1538 Cluster_551274 V1026422 UPPP map00550 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) COG1968 Cluster_823846 V1026423 EPHD S short chain dehydrogenase 175H5@proNOG Cluster_652025 V1026424 BMUL_3648 S metal-dependent hydrolase COG3687 Cluster_656193 V1026429 PYRC map00240,map01100 F Dihydroorotase COG0044 Cluster_468919 V1026430 HSDS V restriction modification system DNA specificity domain COG0732 Cluster_517261 V1026431 ARGG map00250,map00330,map01100,map01110,map01230 E Citrulline--aspartate ligase COG0137 Cluster_471010 V1026437 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_471011 V1026438 S Abortive infection protein 0ZY1D Cluster_533777 V1026439 KTRB P Potassium uptake protein COG0168 Cluster_471012 V1026442 L site-specific recombinase, phage integrase family 0ZF8H Cluster_539543 V1026445 RCSB map02020 T regulatoR COG2197 Cluster_747374 V1026447 YCEH S UPF0502 protein COG3132 Cluster_808252 V1026448 CYST map02010 P sulfate abc transporter COG0555 Cluster_776561 V1026449 BMUL_2952 S Alpha beta hydrolase COG3545 Cluster_533778 V1026450 OHR O Organic hydroperoxide resistance protein COG1764 Cluster_727387 V1026452 PRPD map00640 S 2-methylcitrate dehydratase COG2079 Cluster_471013 V1026456 S Rhomboid family 0ZEJ4 Cluster_471014 V1026461 S alpha-2-macroglobulin COG2373 Cluster_471015 V1026462 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_542276 V1026467 LPDA map00010,map00020,map00260,map00280,map00620,map01100,map01110,map01120 C Flavoprotein disulfide reductase COG1249 Cluster_471016 V1026469 GCVT map00260,map00670,map00910,map01100 E The glycine cleavage system catalyzes the degradation of glycine (By similarity) COG0404 Cluster_471017 V1026471 BCSA map00500,map01100 M Cellulose synthase catalytic subunit COG1215 Cluster_743957 V1026473 CAT1 map00281,map00620,map00626,map01110,map01120 C Transferase COG0427 Cluster_473133 V1026474 G Major Facilitator superfamily 0XPEM Cluster_475257 V1026475 RPOS map05111 K RNA polymerase COG0568 Cluster_475258 V1026476 CLPC2 O ATPase AAA-2 COG0542 Cluster_827744 V1026477 TRKH P Potassium uptake protein COG0168 Cluster_473134 V1026479 S NA 0YRUB Cluster_566172 V1026481 S NA 11GMQ Cluster_850866 V1026482 G Major Facilitator superfamily 0XQKC Cluster_698534 V1026483 ACTP P p-type atpase COG2217 Cluster_737225 V1026485 FDXE C Ferredoxin COG1146 Cluster_695164 V1026488 GROS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) COG0234 Cluster_473136 V1026490 MRCB map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_504199 V1026492 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_473138 V1026494 T ATPase histidine kinase DNA gyrase B HSP90 domain protein 0ZIAQ Cluster_765341 V1026497 TNPT S Cointegrate resolution protein T 173WC@proNOG Cluster_506686 V1026499 HPAR K Transcriptional regulator, MarR family COG1846 Cluster_473141 V1026507 P Binding-protein-dependent transport systems, inner membrane component COG1176 Cluster_591870 V1026512 DPPD E, P ABC transporter COG0444 Cluster_895431 V1026513 DPPC2 P binding-protein-dependent transport systems inner membrane component COG1173 Cluster_704641 V1026514 ARSD P Arsenical resistance operon tranS-acting repressor 11UF3 Cluster_769191 V1026515 ARSA D Arsenite-activated ATPase (ArsA) COG0003 Cluster_509312 V1026516 ACSA map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120 I amp-dependent synthetase and ligase COG0365 Cluster_617009 V1026517 RPSE map03010 J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) COG0098 Cluster_904047 V1026518 RPMD map03010 J 50S ribosomal protein L30 COG1841 Cluster_847186 V1026521 S Transposition protein 16TUU@proNOG Cluster_639998 V1026522 L Transposition protein 16VFT@proNOG Cluster_792195 V1026524 NUPC F nucleoside COG1972 Cluster_475260 V1026525 FRDA map00920,map01100,map01120 C Adenylylsulfate reductase subunit alpha COG1053 Cluster_656195 V1026527 OCAR_4117 S Membrane COG4291 Cluster_473142 V1026528 GCVP map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG1003 Cluster_473143 V1026529 V type i restriction COG0732 Cluster_475261 V1026530 L integrase family 0XRS7 Cluster_473144 V1026531 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_475262 V1026533 MDLB V abc transporter COG1132 Cluster_730757 V1026534 S Triacylglycerol lipase COG1075 Cluster_698535 V1026535 PSTA map02010 P phosphate ABC transporter COG0581 Cluster_788416 V1026536 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_566173 V1026537 DACE_1327 L Transposase COG2801 Cluster_475263 V1026538 TIG O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COG0544 Cluster_475264 V1026539 XYLS map00052,map00500,map01100 G hydrolase, family 31 COG1501 Cluster_475265 V1026540 T ATPase histidine kinase DNA gyrase B HSP90 domain protein COG3706 Cluster_475266 V1026543 TYRB map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aromatic amino acid aminotransferase COG1448 Cluster_525429 V1026544 LHR L helicase COG1201 Cluster_475267 V1026545 GLYA map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01230 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) COG0112 Cluster_854710 V1026546 LTRA L reverse transcriptase COG3344 Cluster_475268 V1026549 PKS13 Q PKS_AT COG3321 Cluster_475269 V1026550 PRPB map00640 G Inherit from COG: methylisocitrate lyase COG2513 Cluster_887183 V1026551 YEJB map02010 P Binding-protein-dependent transport systems, inner membrane component COG4174 Cluster_624516 V1026552 YEJE map02010 P Binding-protein-dependent transport systems inner membrane component COG4239 Cluster_635932 V1026553 S Protein of unknown function (DUF1433) 0XXWQ Cluster_870945 V1026554 S permease COG0701 Cluster_727388 V1026556 S Ragb susd domain-containing protein 0Y93Q Cluster_477467 V1026558 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_475270 V1026559 FTSK D cell division protein FtsK COG1674 Cluster_743959 V1026561 XERD L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_475271 V1026565 S Pfam:DUF2081 COG3472 Cluster_536682 V1026566 K Thioesterase COG0824 Cluster_475272 V1026567 M Beta-Ig-H3 fasciclin COG2335 Cluster_475273 V1026568 BH0416 L Transposase COG3464 Cluster_477468 V1026570 ASNB map00250,map00910,map01100,map01110,map01120 E asparagine synthetase COG0367 Cluster_780134 V1026571 HHA S hemolysin expression-modulating protein 17FM7@proNOG Cluster_831345 V1026573 RRAA K Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) COG0684 Cluster_707792 V1026574 ILVG map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E Thiamine pyrophosphate protein COG0028 Cluster_475274 V1026575 BMUL_1397 K LysR family (Transcriptional regulator 16SB5@proNOG Cluster_613289 V1026576 K MarR family Transcriptional regulator 17E0B@proNOG Cluster_620765 V1026577 YBAB S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) COG0718 Cluster_477469 V1026578 GSIB map02010 E Extracellular solute-binding protein, family 5 COG0747 Cluster_617010 V1026583 S NA 0ZH2P Cluster_477471 V1026584 L Resolvase, N-terminal domain protein COG1961 Cluster_477472 V1026586 O Tryp_SPc 0YAAN Cluster_499217 V1026587 CBIO map02010 P abc transporter COG1122 Cluster_496558 V1026589 P tonB-dependent Receptor COG1629 Cluster_477473 V1026591 SSCG_04189 map00361,map00625,map01100,map01120 S Alpha beta hydrolase 16RJX@proNOG Cluster_572463 V1026596 BITC map02010 P ABC transporter COG1840 Cluster_477474 V1026598 UVRD2 map03420,map03430 L helicase COG2887 Cluster_16501 V1265802 S NA 0YG6V Cluster_12290 V1265803 S NA 11NI8 Cluster_31847 V1265805 S NA 0YDZN Cluster_104615 V1265806 HSDS V restriction modification system DNA specificity domain COG0732 Cluster_13372 V1265807 S NA 0YG6V Cluster_13497 V1265808 S NA 0YZ82 Cluster_469442 V1265809 CORA P transporter COG0598 Cluster_517996 V1265810 RPSP map03010 J 30s ribosomal protein S16 COG0228 Cluster_18320 V1265811 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_135084 V1265814 CYCMA_1561 L Transposase COG3436 Cluster_341056 V1265815 GLNQ map02010 E abc transporter atp-binding protein COG1126 Cluster_14279 V1265819 U, W Pfam:YadA COG5295 Cluster_721713 V1265820 S Addiction module antitoxin, RelB DinJ family 0ZEWM Cluster_14816 V1265822 U, W Pfam:YadA COG5295 Cluster_16215 V1265824 S NA 11NI8 Cluster_298223 V1265825 COBQ S Glutamine amidotransferase COG3442 Cluster_637223 V1265827 S NA 0XWWF Cluster_53055 V1265828 O m6 family metalloprotease domain protein COG4412 Cluster_17564 V1265829 S NA 0YZ82 Cluster_98978 V1265830 M Cell wall binding repeat 2-containing protein COG2247 Cluster_269783 V1265831 BDI_2241 S domain protein 0XNZW Cluster_250340 V1265836 TRPF map00400,map01100,map01110,map01230 E N-(5'-phosphoribosyl)anthranilate isomerase COG0135 Cluster_607065 V1265837 V Beta-lactamase COG1680 Cluster_20682 V1265838 S NA 0YZ82 Cluster_347392 V1265839 S Sel1 repeat COG0790 Cluster_872096 V1265840 S NA 17TV2@proNOG Cluster_471604 V1265841 L DNA alkylation repair enzyme 0YG23 Cluster_129625 V1265842 S NA 0YG6V Cluster_184713 V1265843 map02010 P Periplasmic binding protein 11JWT Cluster_47497 V1265845 TETP T Tetracycline resistance protein COG0480 Cluster_25312 V1265846 S NA 0YZ82 Cluster_387769 V1265847 K, T Peptidase S24-like COG1974 Cluster_56253 V1265848 S NA 11NI8 Cluster_28571 V1265849 CAS3 L CRISPR-associated helicase, cas3 COG1203 Cluster_155308 V1265851 S NA 0YDZN Cluster_44291 V1265852 S NA 0YBPX Cluster_84290 V1265853 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_731657 V1265854 YCHF J gtp-binding protein COG0012 Cluster_431057 V1265855 N Cell surface protein 1DI1G@verNOG Cluster_645096 V1265856 S tm2 domain 11XDS Cluster_583002 V1265857 S NA 0YFUK Cluster_884369 V1265859 S NA 102MI Cluster_34508 V1265862 U, W Pfam:YadA COG5295 Cluster_31970 V1265864 M cell wall-binding protein COG2247 Cluster_32569 V1265866 S NA 0YZ82 Cluster_645097 V1265867 L transposase COG2826 Cluster_322999 V1265868 MIDI_00056 L Transposase 0YEAS Cluster_34638 V1265871 U, W Pfam:YadA COG5295 Cluster_35433 V1265872 S NA 0YZ82 Cluster_35712 V1265873 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_87696 V1265874 ARSB P transporter COG1055 Cluster_277743 V1265875 S Periplasmic Protein COG2859 Cluster_38840 V1265876 U, W Inherit from COG: domain protein COG5295 Cluster_589482 V1265877 L Transposase COG0675 Cluster_273750 V1265878 NRDF map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_40714 V1265879 U, W Pfam:YadA COG5295 Cluster_41522 V1265881 S NA 101UU Cluster_316892 V1265882 H, P abc transporter atp-binding protein COG1120 Cluster_307912 V1265883 YBBM S ABC transporter, permease COG0390 Cluster_74192 V1265884 S NA 0YZ82 Cluster_416218 V1265886 S NA 0Y0MV Cluster_42419 V1265887 S Lpxtg-motif cell wall anchor domain protein 0XQBH Cluster_44490 V1265889 U, W Pfam:YadA COG5295 Cluster_734896 V1265890 L Transposase COG3464 Cluster_567113 V1265892 MVK map00900,map01100,map01110,map04146 I mevalonate kinase COG1577 Cluster_47498 V1265893 U, W Pfam:YadA COG5295 Cluster_48964 V1265894 S NA 11NI8 Cluster_441059 V1265895 O sufB sufD domain protein COG0719 Cluster_51146 V1265896 S NA 11NI8 Cluster_71521 V1265897 S NA 11YT1 Cluster_380628 V1265898 HELD map03420,map03430 L helicase COG3973 Cluster_148103 V1265899 M Putative cell wall binding repeat 2 COG2247 Cluster_53289 V1265901 M Cell wall binding repeat 2-containing protein COG2247 Cluster_55249 V1265902 U, W Pfam:YadA COG5295 Cluster_55760 V1265903 M cell wall binding COG2247 Cluster_327642 V1265904 BIOY map02010 S bioY protein COG1268 Cluster_59351 V1265905 S NA 0YBPX Cluster_59892 V1265906 U, W Pfam:YadA COG5295 Cluster_731659 V1265909 U, W Inherit from COG: domain protein COG5295 Cluster_68903 V1265913 S NA 0ZTYV Cluster_321439 V1265914 MAZG map00230,map00240,map01100 S MazG family COG3956 Cluster_72167 V1265915 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_367063 V1265916 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_148843 V1265917 M Putative cell wall binding repeat 2 COG5492 Cluster_76101 V1265918 U, W Inherit from COG: domain protein 121KM Cluster_242564 V1265919 CYSK map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_163714 V1265921 TILS D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) COG0037 Cluster_156117 V1265922 S Lipase (class 3) 0ZJUJ Cluster_233734 V1265923 FAS map00061,map00350,map00362,map00627,map00642,map00903,map01100,map01120 I synthase COG4982 Cluster_87274 V1265924 S NA 0YG6V Cluster_88582 V1265925 S domain protein 0YF83 Cluster_88583 V1265926 U, W Pfam:YadA COG5295 Cluster_92827 V1265927 M Putative cell wall binding repeat 2 COG5492 Cluster_100024 V1265930 U, W Pfam:YadA COG5295 Cluster_254035 V1265931 SCLAV_3420 map02010,map02020 V abc transporter COG1131 Cluster_586196 V1265933 CBC_0187 S NA 1244F Cluster_109445 V1265934 U, W Pfam:YadA COG5295 Cluster_117010 V1265936 U, W Pfam:YadA COG5295 Cluster_117011 V1265937 U, W Pfam:YadA COG5295 Cluster_451096 V1265940 S NA 0YSBG Cluster_279094 V1265942 FOLP map00790,map01100 H dihydropteroate synthase COG0294 Cluster_473697 V1265945 K lytTr DNA-binding domain protein 11WH8 Cluster_139797 V1265947 U, W Pfam:YadA COG5295 Cluster_257759 V1265949 FIC D cell filamentation protein COG2184 Cluster_147310 V1265950 U, W Pfam:YadA COG5295 Cluster_429084 V1265952 YDJZ S SNARE associated Golgi protein-related protein COG0398 Cluster_375353 V1265953 map00680,map01120 S Phosphotransferase 0Y7VB Cluster_149600 V1265954 S NA 12D73 Cluster_156118 V1265957 U, W Inherit from COG: domain protein 121KM Cluster_290022 V1265959 S NA 0ZTYV Cluster_157840 V1265960 M Putative cell wall binding repeat 2 COG5492 Cluster_158704 V1265961 S NA 0ZHVH Cluster_534611 V1265962 DPPA E ABC transporter substrate-binding protein COG0747 Cluster_238644 V1265968 S NA 11QZ9 Cluster_237321 V1265969 S TPR repeat-containing protein COG0457 Cluster_175361 V1265970 M Putative cell wall binding repeat 2 COG2247 Cluster_232476 V1265971 ZNUA map02010 P transporter substrate-binding protein COG0803 Cluster_570199 V1265972 RPSH map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) COG0096 Cluster_283153 V1265976 S ApbE family 11H27 Cluster_196170 V1265977 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_373642 V1265979 S Inherit from NOG: Mediates binding to human platelets, possibly through a receptor-ligand interaction. Probably associated with virulence in endovascular infection (By similarity) 12CMI Cluster_265709 V1265981 S domain protein 0YF83 Cluster_205074 V1265983 S NA 0YZ82 Cluster_925709 V1265985 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_211633 V1265987 U, W Pfam:YadA COG5295 Cluster_467331 V1265988 SPOU map00340,map00350,map00624,map01120 J tRNA rRNA methyltransferase COG0566 Cluster_323000 V1265989 XYLS map00052,map00500,map01100 G hydrolase, family 31 COG1501 Cluster_683513 V1265990 S Addiction module antitoxin, RelB DinJ family 0XUTM Cluster_423453 V1265991 SFUM_3007 map05100 M Repeat protein COG4886 Cluster_362058 V1265994 M Cell wall binding repeat 2-containing protein COG2247 Cluster_261706 V1265995 L adenine specific DNA methylase COG2189 Cluster_247774 V1265996 U, W Pfam:YadA COG5295 Cluster_401858 V1266000 S RumE protein 0Z8VP Cluster_273751 V1266003 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_412569 V1266005 S Uncharacterised ACR, YkgG family COG1556 0ZXQV Cluster_290023 V1266006 S NA 101UU Cluster_291340 V1266007 S NA 0YZ82 Cluster_294068 V1266008 U, W Pfam:YadA COG5295 Cluster_683514 V1266010 S toxin-antitoxin system, antitoxin component, ribbon-helix-helix 11U5W Cluster_589483 V1266012 S NA 0XWWF Cluster_586197 V1266013 CADD P cadmium resistance COG4300 Cluster_348991 V1266020 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_485119 V1266021 L Inherit from COG: transposase COG5444 Cluster_370386 V1266023 U, W Inherit from COG: domain protein 121KM Cluster_880229 V1266024 S NA 125ZN Cluster_372020 V1266025 U, W Inherit from COG: domain protein COG5295 Cluster_377121 V1266026 U, W Pfam:YadA COG5295 Cluster_378910 V1266027 U, W Inherit from COG: domain protein COG5295 Cluster_396619 V1266031 M Putative cell wall binding repeat 2 COG2247 Cluster_398353 V1266032 U, W Inherit from COG: domain protein 121KM Cluster_401859 V1266033 U, W Pfam:YadA COG5295 Cluster_480464 V1266034 UPPP map00550 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) COG1968 Cluster_418016 V1266037 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_419804 V1266038 S NA 101UU Cluster_421601 V1266039 CCMF O cytochrome c-type biogenesis protein COG1138 Cluster_425260 V1266040 S NA 0ZTYV Cluster_453026 V1266042 S Pfam:YadA 0ZHSU Cluster_455051 V1266043 U, W Pfam:YadA COG5295 Cluster_463153 V1266045 U, W Pfam:YadA COG5295 Cluster_485120 V1266047 S NA 0ZTYV Cluster_507434 V1266050 S NA 101UU Cluster_517997 V1266052 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_579761 V1266053 L Transposase COG0675 Cluster_526221 V1266054 U, W Pfam:YadA COG5295 Cluster_567114 V1266056 S NA 11QZ9 Cluster_583003 V1266058 S NA 0YG6V Cluster_586198 V1266060 map02010 P Cobalt transport protein COG0619 Cluster_607066 V1266064 S Putative cell wall binding repeat 11WSW Cluster_614444 V1266065 CSE4 L Crispr-associated protein, cse4 family 0Y6PV Cluster_629330 V1266067 S NA 12BYI Cluster_797201 V1266068 RPMB map03010 J 50S ribosomal protein l28 COG0227 Cluster_653276 V1266069 MT2794 M LGFP repeat protein COG5479 Cluster_696103 V1266073 U, W Pfam:YadA COG5295 Cluster_708607 V1266075 LGAS_0607 T head morphogenesis protein, SPP1 gp7 COG5585 Cluster_744939 V1266082 S NA 0ZTYV Cluster_755187 V1266088 YAAU G Major Facilitator superfamily 0XQKC Cluster_770157 V1266091 GLTD map00250,map00910,map01100,map01110,map01120,map01230 C, E pyridine nucleotide-disulfide oxidoreductase COG1894 Cluster_781342 V1266093 M Sortase family COG3764 Cluster_781343 V1266094 map00720,map00910,map01120 C oxidoreductase COG1014 Cluster_805345 V1266100 U, W Pfam:YadA COG5295 Cluster_809377 V1266101 H Flavin containing amine oxidoreductase COG1232 Cluster_1014 V1266103 S NA 11SX6 Cluster_16941 V1266104 S Lipase (class 3) 0ZJUJ Cluster_216168 V1266106 S Pfam:YadA 0YNSE Cluster_259090 V1266109 ISPA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_8337 V1266110 INLJ map05150 M Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps 1215X Cluster_151234 V1266111 HSDS V Restriction modification system DNA (Specificity COG0732 Cluster_22102 V1266113 P tonB-dependent Receptor COG4771 Cluster_89521 V1266115 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_243909 V1266117 PANE map00770,map01100,map01110 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) COG1893 Cluster_586199 V1266122 XSEB map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) 121U6 Cluster_29896 V1266125 PFLB map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_456985 V1266128 S NA 11ZC4 Cluster_82551 V1266129 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_291341 V1266131 DGT map00230 F deoxyguanosinetriphosphate triphosphohydrolase-like protein COG0232 Cluster_773842 V1266132 T ATPase histidine kinase DNA gyrase B 0XNMH Cluster_302260 V1266135 COBQ S Glutamine amidotransferase COG3442 Cluster_180354 V1266136 RFBB map00521,map00523,map01055,map01100,map01110 M dtdp-glucose 4,6-dehydratase COG1088 Cluster_24919 V1266138 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_147311 V1266145 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_43495 V1266147 M Cell wall anchor domain protein 11Q8J Cluster_431058 V1266157 HFLX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COG2262 Cluster_344174 V1266159 map02010 P Binding-protein-dependent transport systems, inner membrane component COG0395 Cluster_228956 V1266160 MT2100 map02010 G Binding-protein-dependent transport systems inner membrane component COG1175 Cluster_25211 V1266165 S NA 11NI8 Cluster_494739 V1266166 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120 G phosphohexose isomerase COG0166 Cluster_57517 V1266168 CTPE P ATPase, P-type (Transporting), HAD superfamily, subfamily IC COG0474 Cluster_21852 V1266170 PPC map00620,map00680,map00710,map00720,map01100,map01120 C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) COG2352 Cluster_54758 V1266177 BOPA E Extracellular solute-binding protein, family 5 COG0747 Cluster_251563 V1266179 map00540,map01100 M lipid A biosynthesis COG1560 Cluster_517998 V1266180 YMFM S Transcriptional regulator COG1426 Cluster_128201 V1266183 P integral membrane protein COG1253 Cluster_107646 V1266188 NPLT map00500,map01100,map04973 G alpha amylase, catalytic region COG0366 Cluster_148104 V1266194 PSTS map02010,map02020,map05152 P Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) COG0226 Cluster_160405 V1266203 AROF map00400,map01100,map01110,map01230 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) COG0722 Cluster_144988 V1266206 ASPC map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aspartate aminotransferase COG0436 Cluster_702428 V1266213 G phosphocarrier protein (HPr) 121W9 Cluster_161225 V1266214 RND J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) COG0349 Cluster_61280 V1266217 S NA 0YG6V Cluster_702429 V1266218 YABR J RNA binding s1 domain protein COG1098 Cluster_393024 V1266234 RPLY map03010 J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) COG1825 Cluster_246517 V1266235 HSDR V Type I Restriction COG0610 Cluster_567116 V1266246 SP_0256 K acetyltransferase, (GNAT) family COG0454 Cluster_453027 V1266256 DEF J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) COG0242 Cluster_108199 V1266258 METY map00270,map01100 E DegT/DnrJ/EryC1/StrS aminotransferase family COG2873 Cluster_312293 V1266260 PFLA O Pyruvate formate-lyase COG1180 Cluster_453028 V1266263 S NA 11K8H Cluster_633170 V1266265 S NA 0ZHU9 Cluster_100573 V1266266 U, W Pfam:YadA COG5295 Cluster_105202 V1266268 SCLAV_2116 M glycosyl transferase family 0XPWZ Cluster_117726 V1266274 S NA 0ZTYV Cluster_124763 V1266279 APEB E M18 family aminopeptidase COG1362 Cluster_380629 V1266282 PLSC map00561,map00564,map01100 I Acyl-transferase COG0204 Cluster_848211 V1266283 ILVD map00290,map00770,map01100,map01110,map01210,map01230 E, G Dihydroxy-acid dehydratase COG0129 Cluster_362059 V1266284 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_653278 V1266286 GATC map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0721 Cluster_396620 V1266287 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_226654 V1266304 S NA 11WPM Cluster_813365 V1266305 S NA 0ZHU9 Cluster_855777 V1266316 S NA 0ZHU9 Cluster_323001 V1266323 NHAA map00680 P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) COG3004 Cluster_358808 V1266331 S ApbE family 11H27 Cluster_465233 V1266332 YCGH Q isochorismatase COG1335 Cluster_236126 V1266333 SOJ D Chromosome Partitioning Protein COG1192 Cluster_187342 V1266334 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_189044 V1266337 S NGG1p interacting factor 3 protein, NIF3 COG3323 Cluster_377122 V1266346 DEF1 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) COG0242 Cluster_284524 V1266353 PYRF map00240,map00983,map01100 F orotidine 5''-phosphate decarboxylase COG0284 Cluster_302261 V1266354 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_603447 V1266359 S NA 0ZHU9 Cluster_226655 V1266363 LYSP E permease COG0833 Cluster_721716 V1266364 S NA 0ZHU9 Cluster_478062 V1266384 S NA 0ZHU9 Cluster_260397 V1266391 YFMR S abc transporter COG0488 Cluster_696105 V1266401 S NA 0ZHU9 Cluster_751716 V1266405 S NA 0ZHU9 Cluster_447099 V1266407 SECD map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) COG0342 Cluster_773847 V1266410 S NA 0ZHU9 Cluster_439065 V1266420 SUFB O FeS assembly protein SUFB COG0719 Cluster_554966 V1266428 S Domain of unknown function (DUF1858) 0ZXS1 Cluster_828741 V1266430 U, W Pfam:YadA COG5295 Cluster_708610 V1266436 S NA 0ZHU9 Cluster_414435 V1266443 P Chromate transport protein COG2059 Cluster_678943 V1266467 S NA 0ZHU9 Cluster_408902 V1266483 S NA 0ZHU9 Cluster_721721 V1266486 S NA 0ZHU9 Cluster_641216 V1266497 ACCA map00061,map01100 I carboxylase COG4770 Cluster_614446 V1266498 S NA 0ZHU9 Cluster_352125 V1266499 S NA 11NI8 Cluster_355451 V1266502 TET38 P MFS family major facilitator transporter, tetracycline cation symporter COG0477 Cluster_718401 V1266507 S NA 0ZHU9 Cluster_360478 V1266514 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Involved in acetate metabolism (By similarity) COG0280 Cluster_367064 V1266521 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_711788 V1266523 S NA 0ZHU9 Cluster_368685 V1266525 Y2366 V ABC transporter, permease COG0577 Cluster_603449 V1266529 S NA 0ZHU9 Cluster_520574 V1266544 S NA 0ZHU9 Cluster_607070 V1266548 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_403650 V1266581 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_696107 V1266585 S NA 0ZHU9 Cluster_421602 V1266592 4HBD map00650 C NAD-dependent 4-hydroxybutyrate dehydrogenase COG1454 Cluster_592887 V1266600 S NA 0ZHU9 Cluster_715161 V1266625 S NA 0ZHU9 Cluster_429085 V1266640 ACRB3 P RND transporter, HAE1 HME family, permease protein COG0841 Cluster_478063 V1266647 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_445051 V1266685 TYPA T gtp-binding protein typa COG1217 Cluster_734901 V1266687 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_718403 V1266715 S NA 0ZHU9 Cluster_456986 V1266723 MT3296 L helicase COG0210 Cluster_734902 V1266728 S NA 0ZHU9 Cluster_718405 V1266731 S NA 0ZHU9 Cluster_734903 V1266735 S NA 0ZHU9 Cluster_589485 V1266736 S ApbE family 11H27 Cluster_728383 V1266752 S NA 0ZHU9 Cluster_473699 V1266754 V Type I restriction enzyme R protein N terminus (HSDR_N) COG0610 Cluster_475874 V1266762 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_696111 V1266773 S NA 17D58@proNOG Cluster_482792 V1266785 HEMN map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_492249 V1266806 MT2794 M LGFP repeat protein COG5479 Cluster_507436 V1266814 CAS3 L CRISPR-associated helicase, cas3 COG1203 Cluster_507437 V1266842 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_510031 V1266860 SUFC O feS assembly ATPase SufC COG0396 Cluster_512613 V1266864 S kila-n, DNA-binding domain 0XPNQ Cluster_586201 V1266870 S NA 0ZHU9 Cluster_518002 V1266871 ALGI M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_518003 V1266875 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_526225 V1266891 S NA 0ZTYV Cluster_528987 V1266899 S NA 0ZHU9 Cluster_766444 V1266902 S NA 0ZHU9 Cluster_528988 V1266904 YJIN S Membrane COG2733 Cluster_657409 V1266911 S NA 0ZHU9 Cluster_540295 V1266924 MNTA map02010 P periplasmic solute binding protein COG0803 Cluster_657410 V1266933 S NA 11K9E Cluster_820983 V1266941 S NA 0ZHU9 Cluster_900874 V1266948 S NA 0ZHU9 Cluster_552079 V1266956 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_563916 V1266983 map00020,map00300,map00630,map00720,map01100,map01110,map01120,map01210,map01230 C Aconitase family COG1048 Cluster_880244 V1266991 PDXP G hydrolase COG0647 Cluster_880246 V1267002 BDI_2241 S domain protein 0XNZW Cluster_618201 V1267044 YEBC K transcriptional regulatory protein COG0217 Cluster_892420 V1267045 S NA 0ZHU9 Cluster_711790 V1267054 YLQF K Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) COG1161 Cluster_653280 V1267066 S NA 0ZHU9 Cluster_603452 V1267072 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_840299 V1267102 S NA 0ZHU9 Cluster_621834 V1267116 GLNE O, T Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) COG1391 Cluster_625635 V1267119 S conjugative transposon membrane protein 11G5T Cluster_836375 V1267125 S NA 0ZHU9 Cluster_741635 V1267144 M glycosyl transferase COG1215 Cluster_645102 V1267161 MVAD map00900,map01100,map01110 I diphosphomevalonate decarboxylase COG3407 Cluster_670127 V1267165 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_653281 V1267168 LYSX map00970,map05150 J Membrane COG2898 Cluster_702433 V1267173 map00521,map00523,map01100,map01110 M dTDP-4-dehydrorhamnose 3,5-epimerase COG1898 Cluster_797211 V1267179 YHAO E Serine transporter COG0814 Cluster_683516 V1267215 PITA P phosphate transporter COG0306 Cluster_876212 V1267229 S NA 0ZHU9 Cluster_67531 V1267245 CASA L crispr-associated protein 0XPA1 Cluster_72489 V1267246 MOD L DNA methylase COG2189 Cluster_3151 V1267247 U, W Pfam:YadA COG5295 Cluster_164508 V1267248 YFMR S ABC transporter, ATP-binding protein COG0488 Cluster_4433 V1267249 U, W Inherit from COG: domain protein COG5295 Cluster_246518 V1267250 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_241190 V1267251 LYC M glycoside hydrolase, family 25 11T0J Cluster_160406 V1267252 S Inherit from NOG: domain protein 0XQTW Cluster_212725 V1267254 ELI_1308 S tail protein 11P2A Cluster_107647 V1267255 ELI_1314 S NA 0XT3I Cluster_11949 V1267262 U, W domain protein COG5295 Cluster_3205 V1267264 MT3296 L helicase COG0210 Cluster_91394 V1267265 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_286 V1267266 FAS map00061,map00350,map00362,map00627,map00642,map00903,map01100,map01120 I synthase COG4982 Cluster_336 V1267267 S NA 0ZTYV Cluster_3844 V1267268 S Pfam:YadA 126HB Cluster_14174 V1267269 XYLS map00052,map00500,map01100 G hydrolase, family 31 COG1501 Cluster_368686 V1267270 S NA 11QRM Cluster_15902 V1267271 SCLAV_1560 map02010 P ABC transporter COG1122 Cluster_335101 V1267272 MOEB map00730,map01100,map04122 H uba thif-type nad fad binding protein COG0476 Cluster_156119 V1267273 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0470 Cluster_179520 V1267274 TYRA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydrogenase COG0287 Cluster_98979 V1267275 D Maf-like protein COG0424 Cluster_8819 V1267276 CAFA map03018 J ribonuclease COG1530 Cluster_313793 V1267277 MURI map00471,map01100 M Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) COG0796 Cluster_512614 V1267278 BCELL_1025 L Integrase COG2801 Cluster_26469 V1267280 FNI map00900,map01100,map01110 C Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) COG1577 Cluster_288738 V1267281 S haloacid dehalogenase-like hydrolase COG0561 Cluster_490 V1267282 U, W Pfam:HIM COG5295 Cluster_176969 V1267283 MRP D ATP-binding protein COG0489 Cluster_34780 V1267284 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_285975 V1267285 YEAZ O Peptidase M22 Glycoprotease COG1214 Cluster_316893 V1267286 COMA I phospholipase d COG1502 Cluster_134292 V1267287 G extracellular solute-binding protein family 1 COG1653 Cluster_589486 V1267288 PURC map00230,map01100,map01110 F SAICAR synthetase COG0152 Cluster_173733 V1267289 M Sortase family COG3764 Cluster_65700 V1267290 M Cell wall anchor domain protein 11Q8J Cluster_31971 V1267293 FTSK D cell division protein FtsK COG1674 Cluster_69272 V1267294 M Cell wall anchor domain protein 11Q8J Cluster_7930 V1267295 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_246519 V1267296 S NA 11WEI Cluster_102274 V1267297 OPPD S ABC transporter COG4172 Cluster_345793 V1267298 OPPCD E, P abc transporter COG1173 Cluster_61281 V1267299 S NA 129FA Cluster_28865 V1267300 S NA 103RQ Cluster_13077 V1267301 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_321440 V1267302 LOLD V abc transporter atp-binding protein COG1136 Cluster_570 V1267304 S NA 101UU Cluster_1839 V1267305 U, W surface protein COG5295 Cluster_110067 V1267306 MVAA map00900,map01100,map01110,map04976 I hydroxymethylglutaryL-CoA reductase COG1257 Cluster_136703 V1267307 MVAS map00072,map00280,map00650,map00900,map01100,map01110 I Hydroxymethylglutaryl-CoA synthase COG3425 Cluster_110068 V1267308 PIP map00330 L Prolyl aminopeptidase COG0596 Cluster_50168 V1267309 map02010 V abc transporter COG1132 Cluster_25313 V1267311 PARE L DNA topoisomerase IV subunit B COG0187 Cluster_200916 V1267312 FTSK D cell division protein FtsK COG1674 Cluster_407130 V1267313 PROA map00330,map01100,map01230 E Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) COG0014 Cluster_378911 V1267316 COBQ S Glutamine amidotransferase COG3442 Cluster_482793 V1267317 SCLAV_1116 S metal-sulfur cluster biosynthetic COG2151 Cluster_1955 V1267318 S NA 11NI8 Cluster_139798 V1267319 NAGA map00520,map01110 G GlcNAc 6-P deacetylase COG1820 Cluster_53519 V1267320 CKL_1868 S NA 0XRCN Cluster_225534 V1267321 S ABC transporter transmembrane protein 11H9G Cluster_37021 V1267322 map02010 P ABC transporter COG1131 Cluster_100025 V1267327 S NA 1021S Cluster_203994 V1267328 S ApbE family 11H27 Cluster_333593 V1267329 S NA 0ZHU9 Cluster_21409 V1267332 L HELICc COG4581 Cluster_58801 V1267333 BOPA E Extracellular solute-binding protein, family 5 COG0747 Cluster_49589 V1267334 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_844332 V1267336 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_45574 V1267337 map01054 Q amino acid adenylation COG0318 Cluster_23691 V1267338 S NA 0YG6V Cluster_78791 V1267339 S domain protein 0YF83 Cluster_487414 V1267341 PULA G Glycogen debranching enzyme COG1523 Cluster_318477 V1267342 BAS0367 map02010 P Binding-protein-dependent transport systems, inner membrane component COG0600 Cluster_8360 V1267343 S NA 0YG6V Cluster_267026 V1267345 CAS5E L crispr-associated protein 11JEJ Cluster_377123 V1267347 SCLAV_3539 G phosphoglycerate mutase COG0406 Cluster_246520 V1267348 CAS3 L CRISPR-associated helicase, cas3 COG1203 Cluster_273752 V1267349 LYC M glycoside hydrolase, family 25 11T0J Cluster_268437 V1267350 SCLAV_3420 map02010,map02020 V abc transporter COG1131 Cluster_327643 V1267351 SSCG_03340 S Membrane COG2860 Cluster_534613 V1267352 S NA 102RM Cluster_596349 V1267353 S Addiction module antitoxin, RelB DinJ family 0XUTM Cluster_24188 V1267354 U, W Inherit from COG: domain protein 121KM Cluster_387770 V1267355 P19 P Periplasmic Protein COG3470 Cluster_20155 V1267356 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_21853 V1267357 U, W Pfam:YadA COG5295 Cluster_711793 V1267359 XYLS map00052,map00500,map01100 G hydrolase, family 31 COG1501 Cluster_48079 V1267360 STHIM L DNA methylase COG2189 Cluster_26152 V1267362 S NA 0ZTYV Cluster_641222 V1267366 RND J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) COG0349 Cluster_26992 V1267367 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_27971 V1267368 S NA 0YZ82 Cluster_170353 V1267369 I diacylglycerol kinase, catalytic COG1597 Cluster_29306 V1267373 S NA 0ZTYV Cluster_173734 V1267378 4HBD map00650 C NAD-dependent 4-hydroxybutyrate dehydrogenase COG1454 Cluster_208385 V1267379 S Membrane COG0628 Cluster_38140 V1267381 U, W Pfam:YadA COG5295 Cluster_39308 V1267382 INLJ map05150 M Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps 1215X Cluster_70899 V1267383 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_48080 V1267384 INLJ map05150 M Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps 1215X Cluster_227794 V1267388 S NA 10255 Cluster_330537 V1267389 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_469443 V1267391 map00051,map00500,map00520,map01100 G pfkb domain protein COG0524 Cluster_72490 V1267392 M Inherit from NOG: Lpxtg-motif cell wall anchor domain protein 0Y6CS Cluster_766448 V1267394 TNPX L Site-specific recombinase COG1961 Cluster_352126 V1267395 RPLY map03010 J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) COG1825 Cluster_629334 V1267398 S von Willebrand factor, type A 11KUS Cluster_65108 V1267399 MALQ map00500,map01100 G 4-alpha-glucanotransferase COG1640 Cluster_407131 V1267402 map00550,map01100 M carboxy-peptidase COG1686 Cluster_674520 V1267404 S Amidohydrolase COG3618 Cluster_276435 V1267405 GLUB map02010,map02020 E, T Extracellular solute-binding protein family 3 COG0834 Cluster_279096 V1267409 M Sortase family COG3764 Cluster_273753 V1267410 RNC map03008,map05205 K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) COG0571 Cluster_91874 V1267414 U, W Pfam:YadA COG5295 Cluster_864158 V1267416 S NA 0ZHU9 Cluster_357157 V1267417 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_368687 V1267419 S NA 0ZHU9 Cluster_277744 V1267420 SUFB O FeS assembly protein SUFB COG0719 Cluster_197927 V1267424 S ApbE family 11H27 Cluster_255241 V1267425 map00051,map00500,map00520,map01100 G pfkb domain protein COG0524 Cluster_288739 V1267429 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_573434 V1267432 S NA 0XZ3T Cluster_836377 V1267433 DNAJ1 O DnaJ domain protein COG2214 Cluster_149601 V1267435 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_176970 V1267440 CREC map02020 T Histidine kinase COG0642 Cluster_181173 V1267443 S TPR repeat-containing protein COG0457 Cluster_162066 V1267447 U, W Pfam:YadA COG5295 Cluster_441060 V1267451 LUXS map00270,map05111 T Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) COG1854 Cluster_281742 V1267453 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_335102 V1267454 MRCB map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_653283 V1267455 GLXR map02020,map05111 T transcriptional regulator, crp fnr family COG0664 Cluster_259091 V1267460 S NA 11IEF Cluster_563917 V1267464 S NA 0ZHU9 Cluster_357158 V1267465 YUIF S Na H antiporter COG2056 Cluster_412571 V1267466 S NA 0ZHU9 Cluster_344175 V1267468 NRDG O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) COG0602 Cluster_360479 V1267469 OPPB1 P Binding-protein-dependent transport systems inner membrane component COG0601 Cluster_249088 V1267474 LDH map00010,map00051,map00270,map00363,map00591,map00620,map00625,map00640,map00650,map01100,map01110,map01120 C Dehydrogenase COG0039 Cluster_195317 V1267475 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_196171 V1267476 SDAA map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase COG1760 Cluster_549192 V1267478 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_210507 V1267481 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_418018 V1267482 S alkaline shock protein COG1302 Cluster_201901 V1267483 S NA 11NI8 Cluster_414437 V1267484 S NA 101UU Cluster_213835 V1267487 ASPC map00250,map00290,map01100,map01110,map01210,map01230 E Aminotransferase COG0436 Cluster_215028 V1267489 DPRA L DNA protecting protein DprA COG0758 Cluster_515332 V1267492 S NA 11FZK Cluster_276436 V1267495 S kila-n, DNA-binding domain 0XPNQ Cluster_563918 V1267496 S NA 0ZHU9 Cluster_855790 V1267497 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E brancheD-chain amino acid aminotransferase COG0115 Cluster_699390 V1267501 S NA 0ZHU9 Cluster_287373 V1267502 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_748294 V1267503 AROE map00400,map01100,map01110,map01230 E shikimate COG0169 Cluster_515333 V1267505 SCLAV_4722 J Methyltransferase COG2813 Cluster_534615 V1267506 S Uncharacterised protein family (UPF0150) 101HY Cluster_330538 V1267507 V abc transporter COG1132 Cluster_260398 V1267513 U, W Pfam:YadA COG5295 Cluster_497248 V1267514 NRDI F Probably involved in ribonucleotide reductase function (By similarity) COG1780 Cluster_618204 V1267515 NRDH O (Glutaredoxin-like protein) NrdH COG0695 Cluster_261707 V1267516 S domain protein 0YF83 Cluster_855791 V1267522 S NA 0ZHU9 Cluster_271088 V1267523 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_273754 V1267526 M Sortase family COG3764 Cluster_543221 V1267529 METF map00670,map00720,map01100,map01120 E Methylenetetrahydrofolate reductase COG0685 Cluster_531821 V1267530 FAHA Q 5-carboxymethyl-2-hydroxymuconate Delta-isomerase (EC 5.3.3.10) COG0179 Cluster_674522 V1267533 S NA 0ZHU9 Cluster_510032 V1267537 NRDR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) COG1327 Cluster_905171 V1267539 S NA 0ZHU9 Cluster_512616 V1267542 Q AMP-binding enzyme COG1020 Cluster_633173 V1267543 S Domain of unknown function DUF87 COG0433 Cluster_687949 V1267545 S NA 0ZHU9 Cluster_482794 V1267546 LYTR2 K TRANSCRIPTIONal COG1316 Cluster_318478 V1267549 FBA map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01230 G fructose-bisphosphate aldolase COG0191 Cluster_560941 V1267553 S NA 0ZHU9 Cluster_312294 V1267557 HELY L helicase COG4581 Cluster_312295 V1267558 GLNE O, T Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) COG1391 Cluster_797213 V1267562 YAZB K HTH_XRE COG1396 Cluster_391213 V1267563 PSEH map00330,map00350,map00362,map00520,map00627,map00642,map00903,map01100,map01120 J -acetyltransferase COG1670 Cluster_711794 V1267564 S NA 0ZHU9 Cluster_487415 V1267566 RUMG map02010 S Inherit from COG: permease COG4200 Cluster_329129 V1267569 PARB K parb-like partition protein COG1475 Cluster_336638 V1267575 S NA 0YG6V Cluster_699391 V1267582 Q amino acid adenylation domain protein COG1020 Cluster_557888 V1267583 IRP3 map01053 Q Thiazolinyl imide reductase COG4693 Cluster_345794 V1267584 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG1754 Cluster_403651 V1267586 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_554969 V1267593 map00361,map00625,map01100,map01120 S had-superfamily hydrolase, subfamily ia, variant COG1011 Cluster_360480 V1267594 V type I restriction-modification COG0286 Cluster_603453 V1267597 G Aamy_C COG1523 Cluster_363626 V1267602 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_467333 V1267604 S Inherit from NOG: domain protein 18D01@proNOG Cluster_368688 V1267605 BT_0485 L transposase is116 is110 is902 family COG3547 Cluster_445052 V1267608 S Saccharopine dehydrogenase 11P3S Cluster_370387 V1267611 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_473700 V1267620 L transposase COG3039 Cluster_384178 V1267625 GSIA map02010 E, P ABC transporter COG0444 Cluster_385958 V1267626 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_385959 V1267627 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_389484 V1267630 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_621835 V1267631 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_410754 V1267632 V efflux transporter, rnd family, mfp subunit COG0845 Cluster_393025 V1267634 CBPA M Choline binding protein A 11T5H Cluster_394836 V1267636 S NA 0ZHU9 Cluster_408903 V1267642 DHAL map00561,map01100 G Dihydroxyacetone kinase COG2376 Cluster_421603 V1267644 THRC map00260,map00750,map01100,map01120,map01230 E Threonine synthase COG0498 Cluster_576633 V1267645 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_412572 V1267647 PARB K parb-like partition protein COG1475 Cluster_403652 V1267651 S NA 0YG6V Cluster_405469 V1267652 YCHF J gtp-binding protein COG0012 Cluster_405470 V1267654 LIVH map02010 E branched-chain amino acid ABC transporter, permease protein COG0559 Cluster_408904 V1267658 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_408905 V1267660 SCLAV_1560 map02010 P ABC transporter COG1122 Cluster_408906 V1267662 RECG map03440 L ATP-dependent DNA helicase RecG COG1200 Cluster_414438 V1267664 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_603454 V1267665 S NA 1021S Cluster_781359 V1267667 K Inherit from COG: Transcriptional regulator COG3655 Cluster_416219 V1267668 SUFC O feS assembly ATPase SufC COG0396 Cluster_494742 V1267685 GLPF G Major Intrinsic Protein COG0580 Cluster_599858 V1267691 S NA 0ZHU9 Cluster_434977 V1267695 RES_1 V type IIi COG3421 Cluster_434978 V1267698 RNHB map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0164 Cluster_437043 V1267700 ARGS map00970 J arginyL-tRNA synthetase COG0018 Cluster_437044 V1267701 RV1825 S Bacterial protein of unknown function (DUF881) COG3879 Cluster_451099 V1267716 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_621836 V1267717 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_567120 V1267720 S NA 0Y9Z0 Cluster_453029 V1267723 OPPD S ABC transporter COG4172 Cluster_455053 V1267724 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_453030 V1267725 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_456987 V1267732 map00051 M glycosyltransferase, group 2 family protein COG0463 Cluster_557889 V1267738 S NA 0ZTYV Cluster_844336 V1267739 S RumE protein 0Z8VP Cluster_499909 V1267743 NRNA J phosphoesterase RecJ domain protein COG0618 Cluster_813381 V1267745 S Uncharacterised protein, DegV family COG1307 0YGG8 Cluster_502454 V1267747 HYPA O Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) COG0375 Cluster_751725 V1267752 S NA 0YFUK Cluster_465234 V1267755 PULA G Glycogen debranching enzyme COG1523 Cluster_502455 V1267771 S NA 0ZHU9 Cluster_480465 V1267774 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_480466 V1267779 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_482795 V1267780 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E brancheD-chain amino acid aminotransferase COG0115 Cluster_832544 V1267781 S NA 0ZHU9 Cluster_482796 V1267783 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_482797 V1267784 S Inherit from NOG: Lpxtg-motif cell wall anchor domain protein 12B3D Cluster_485122 V1267786 G Major Facilitator 0XP2I Cluster_805355 V1267787 RARA L recombination factor protein RarA COG2256 Cluster_487416 V1267789 K Transcriptional regulator, TetR family 11JD6 Cluster_773863 V1267791 S NA 0ZHU9 Cluster_489761 V1267795 ANMK O Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) COG2377 Cluster_528989 V1267800 SCLAV_2642 S Lipase esterase 11GU9 Cluster_477475 V1026602 S NA 0ZHU9 Cluster_477476 V1026604 MRDA map00550 M Penicillin-binding protein 2 COG0768 Cluster_656196 V1026605 NBCG_03603 S Protein of unknown function (DUF3027) 11G10 Cluster_479835 V1026609 LPXC map00061,map00540,map01100 M involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) COG0774 Cluster_477477 V1026611 OTSA map00500,map01100 G alpha-alpha-trehalose-phosphate synthase COG0380 Cluster_835303 V1026612 RSME S Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) COG1385 Cluster_477478 V1026613 S Lpxtg-motif cell wall anchor domain protein 0XQBH Cluster_714268 V1026615 H cobalamin (vitamin b12) biosynthesis cbix protein COG2138 Cluster_578783 V1026616 SUCB map00010,map00020,map00280,map00310,map00620,map01100,map01110,map01120 C 2-oxoglutarate dehydrogenase E2 component, dihydrolipoamide succinyltransferase COG0508 Cluster_557026 V1026617 S Transposition protein 17B81@proNOG Cluster_479836 V1026618 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_477479 V1026619 ACRB3 P acriflavin resistance protein COG0841 Cluster_509313 V1026620 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_477480 V1026621 S NA 183XB@proNOG Cluster_477481 V1026622 S NA 0XRDA Cluster_477482 V1026623 PRPC map00020,map00630,map00640,map01100,map01110,map01120,map01210,map01230 C citrate synthase COG0372 Cluster_617011 V1026625 GROS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) COG0234 Cluster_477483 V1026626 ACRB3 P acriflavin resistance protein COG0841 Cluster_479837 V1026629 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_479838 V1026630 PROB map00330,map01100,map01230 E Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) COG0263 Cluster_477484 V1026632 YJDA S vimentin COG0699 Cluster_704642 V1026637 COPA Q Multicopper oxidase COG2132 Cluster_664550 V1026639 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_639999 V1026640 S NIPSNAP family containing protein 17F1T@proNOG Cluster_479839 V1026644 P Receptor COG1629 Cluster_750749 V1026645 PFOR G Perfringolysin O regulator protein COG1299 Cluster_605960 V1026646 RBFA J Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) COG0858 Cluster_479840 V1026651 LMRA V ABC transporter, ATP-binding protein COG1132 Cluster_581990 V1026654 UGPB map02010 G extracellular solute-binding protein family 1 COG1653 Cluster_479842 V1026656 LACG map00052,map01100 G Glycosyl hydrolase family 1 COG2723 Cluster_585231 V1026660 RIHC map00230,map00240,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_545258 V1026661 CITA G metabolite H symporter, major facilitator superfamily 16QT5@proNOG Cluster_776563 V1026662 L helicase 0XQUD Cluster_717519 V1026663 YEEC S YeeC-like protein 0XQYQ Cluster_479843 V1026664 GLTA map00020,map00630,map01100,map01110,map01120,map01210,map01230 C citrate synthase COG0372 Cluster_831346 V1026667 RFAC map00540,map01100 M lipopolysaccharide heptosyltransferase i COG0859 Cluster_720806 V1026668 ALGC map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G phosphomannomutase COG1109 Cluster_479844 V1026674 SGLY_0535 S phage protein 0XNW6 Cluster_482163 V1026676 GSIB map02010 E Extracellular solute-binding protein, family 5 COG0747 Cluster_479845 V1026682 SURB S G5 domain protein 0ZVV3 Cluster_479846 V1026683 REP map03420,map03430 L Helicase COG0210 Cluster_482166 V1026684 PDHR K transcriptional regulator COG2186 Cluster_482167 V1026687 O Band 7 protein COG0330 Cluster_482168 V1026688 COBM map00860,map01100 H precorrin-4 C(11)-methyltransferase COG2875 Cluster_482170 V1026690 AROG map00400,map01100,map01110,map01230 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) COG0722 Cluster_482171 V1026691 ECFA1 map02010 P abc transporter COG1122 Cluster_482172 V1026693 S NA 0ZHVH Cluster_482173 V1026694 REPA L Replication Protein 17KMR@proNOG Cluster_482174 V1026695 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_750751 V1026696 HRTA map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_858511 V1026700 S integral membrane protein COG4705 Cluster_560081 V1026702 NASF map00910,map02010 P Transporter COG0715 Cluster_482176 V1026704 V Type III COG3587 Cluster_506687 V1026709 GLTS E Sodium Glutamate Symporter COG0786 Cluster_484479 V1026711 TGT J Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COG0343 Cluster_482177 V1026712 THIC map00730,map01100 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) COG0422 Cluster_677657 V1026713 S Putative trans-membrane protein 17DV4@proNOG Cluster_482178 V1026714 GLGC map00500,map00520,map01100,map01110 G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) COG0448 Cluster_484480 V1026715 map02010,map02020,map05152 P ABC transporter COG0226 Cluster_484481 V1026720 S Inherit from NOG: domain protein 18D01@proNOG Cluster_640001 V1026724 TRXA O Thioredoxin COG0526 Cluster_557027 V1026725 G Cupin 2, conserved barrel domain protein COG0662 Cluster_491611 V1026727 S Alpha Beta Hydrolase COG4757 Cluster_491612 V1026729 O Secreted protein COG1651 Cluster_647929 V1026730 CRCB D Protein CrcB homolog COG0239 Cluster_484482 V1026734 BL00969 S NA 0XYM3 Cluster_486793 V1026738 G Major Facilitator superfamily 0XQFH Cluster_486794 V1026739 CAPD map00521,map00523,map01055,map01100,map01110 M Polysaccharide biosynthesis protein COG1086 Cluster_560082 V1026741 S Membrane COG2149 Cluster_605961 V1026744 S NA COG4926 Cluster_486795 V1026745 RARA L recombination factor protein RarA COG2256 Cluster_804287 V1026750 BMUL_3526 K LysR family (Transcriptional regulator COG0583 Cluster_870947 V1026751 ARGC map00330,map01100,map01110,map01210,map01230 E N-acetyl-gamma-glutamyl-phosphate reductase COG0002 Cluster_486796 V1026755 YDBC map00051,map00363,map00591,map00625,map00650,map01100,map01120 C aldo keto reductase 16SR0@proNOG Cluster_908221 V1026756 K Transcriptional regulator 17MIZ@proNOG Cluster_575687 V1026759 LACA map00350,map00362,map00627,map00642,map00903,map01120 S Galactoside O-acetyltransferase COG0110 Cluster_486797 V1026760 MBL1 map00311,map00312,map01110,map02020 S Beta-lactamase COG0491 Cluster_486798 V1026761 S NA 1278K Cluster_486799 V1026762 MTAD map00791,map01100,map01120 F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) COG0402 Cluster_891225 V1026763 MOEB map00730,map01100,map04122 H uba thif-type nad fad binding protein COG0476 Cluster_484484 V1026765 map03440 L UvrD REP helicase COG1074 Cluster_772751 V1026767 AARI_34720 L Transposase COG3547 Cluster_486800 V1026770 YADN S Fimbrial-like protein 17BXI@proNOG Cluster_588498 V1026777 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_501752 V1026778 S Glutamine amidotransferase, class-II COG0121 Cluster_591871 V1026781 L DNA methylase COG0863 Cluster_486801 V1026782 SFMD map05133 M outer membrane usher protein COG3188 Cluster_496559 V1026783 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_486802 V1026784 map01053 Q non-ribosomal peptide synthetase COG1020 Cluster_486803 V1026786 CBRC S bacteriocin immunity COG3196 Cluster_486804 V1026790 map00071,map00310,map00380,map01100 I Dehydrogenase COG1960 Cluster_486805 V1026791 U, W Pfam:YadA COG5295 Cluster_489076 V1026793 P tonB-dependent Receptor COG4771 Cluster_548301 V1026796 K Transcriptional regulator COG1609 Cluster_489077 V1026800 S domain protein 0XPXI Cluster_492250 V1267802 L NA 121AE Cluster_497249 V1267805 PURA map00230,map00250,map01100 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis COG0104 Cluster_499910 V1267808 K Sigma54 specific transcriptional regulator, Fis family COG3829 Cluster_502456 V1267814 Q AMP-binding enzyme COG1020 Cluster_502457 V1267817 S NA 0YG6V Cluster_793237 V1267821 RUVA map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) COG0632 Cluster_504857 V1267822 G Major Facilitator 12APV Cluster_504858 V1267826 S SAM-dependent methyltransferase COG1092 Cluster_510034 V1267838 IRP3 map01053 Q Thiazolinyl imide reductase COG4693 Cluster_531823 V1267842 E Dipeptide ABC transporter periplasmic component-like protein COG0747 Cluster_512617 V1267843 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG0582 Cluster_789458 V1267845 E Peptidase dimerisation domain COG1473 Cluster_515334 V1267849 G 4-alpha-glucanotransferase COG1640 Cluster_512618 V1267850 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_781362 V1267857 S NA 0ZHU9 Cluster_579765 V1267861 PEPN map00480,map01100 E Aminopeptidase COG0308 Cluster_520576 V1267867 SP_1668 S TIGR02206 family 11T9J Cluster_586202 V1267876 J t-RNA-binding domain protein COG0073 Cluster_523319 V1267879 S NA 0ZTYV Cluster_751726 V1267883 BT_0485 L transposase is116 is110 is902 family COG3547 Cluster_534616 V1267884 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_913508 V1267891 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_751727 V1267892 F Glutamine amidotransferases class-II COG0034 Cluster_813385 V1267898 RV2923C O OsmC family COG1765 Cluster_540296 V1267911 S NA 11NI8 Cluster_543224 V1267922 S NA 0YZ82 Cluster_766451 V1267924 S domain protein 0YF83 Cluster_549194 V1267927 map02010 V abc transporter COG1132 Cluster_801189 V1267929 S NA 0ZHU9 Cluster_552081 V1267930 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate (By similarity) COG0167 Cluster_809395 V1267932 S integral membrane protein 11P1U Cluster_751729 V1267933 IUNH2 map00230,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_563920 V1267941 S Int_alpha 0ZYU3 Cluster_715169 V1267947 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_570204 V1267951 K AraC Family Transcriptional Regulator COG2207 Cluster_614449 V1267955 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_570205 V1267956 DLTB map05150 M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_570206 V1267958 S NA 0XWR2 Cluster_824957 V1267961 S Filamentation induced by cAMP protein fic COG3177 Cluster_705538 V1267964 THRB map00260,map01100,map01120,map01230 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) COG0083 Cluster_678950 V1267965 S NA 0ZHU9 Cluster_576634 V1267968 S Lpxtg-motif cell wall anchor domain protein 0XQBH Cluster_579766 V1267971 L transposase COG3328 Cluster_832549 V1267972 S NA 0ZHU9 Cluster_859853 V1267973 S NA 0ZHU9 Cluster_583007 V1267982 S NA 0YZ82 Cluster_583008 V1267983 map00052,map00500,map01100 G alpha-glucosidase EC 3.2.1.20 COG1501 Cluster_589488 V1267986 YJHA S Endonuclease Exonuclease phosphatase 0XNVA Cluster_589489 V1267995 P SNF family Na -dependent transporter COG0733 Cluster_824958 V1267998 S NA 0ZHU9 Cluster_592889 V1268004 RNY S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 Cluster_596354 V1268005 Q Nonribosomal peptide synthase COG1020 Cluster_592890 V1268006 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG2812 Cluster_738242 V1268015 Y0750 S Conserved Protein COG3586 Cluster_599859 V1268023 G Aamy_C COG1523 Cluster_607074 V1268024 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_603457 V1268025 MREC M Involved in formation and maintenance of cell shape (By similarity) COG1792 Cluster_603458 V1268026 DLTD map05150 M D-alanyl-lipoteichoic acid biosynthesis protein DltD COG3966 Cluster_718415 V1268027 S NA 100RW Cluster_610726 V1268040 TMK map00240,map01100 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) COG0125 Cluster_618205 V1268060 T Serine Threonine protein kinase COG0515 Cluster_618206 V1268061 DCK map00230,map00240,map01100 F deoxynucleoside kinase COG1428 Cluster_621839 V1268062 S NA 0ZHU9 Cluster_621840 V1268065 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G Phosphohexokinase COG0205 Cluster_766453 V1268067 S NA 125T8 Cluster_621841 V1268074 YEAO S MarR family Transcriptional regulator COG3189 Cluster_657412 V1268078 APPF map02010 E (ABC) transporter COG4608 Cluster_629338 V1268083 TRPB map00260,map00400,map01100,map01110,map01230 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) COG0133 Cluster_629339 V1268084 S NA 0YZ82 Cluster_633175 V1268087 RPOD map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_633176 V1268096 GUAB3 map00230,map00983,map01100,map01110 F Dehydrogenase COG0516 Cluster_738243 V1268103 S NA 0ZHU9 Cluster_645103 V1268111 S NA 0ZHU9 Cluster_641224 V1268112 LYSX map00970,map05150 J Membrane COG2898 Cluster_641225 V1268113 TSNR J rrna methyltransferase COG0566 Cluster_645104 V1268116 MDLA V ABC transporter, ATP-binding protein COG1132 Cluster_649201 V1268124 S NA 0ZTYV Cluster_744949 V1268136 S NA 0ZHU9 Cluster_653284 V1268137 RLMC map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) COG2265 Cluster_653285 V1268138 CYDC map02010 V ABC transporter, ATP-binding protein COG1132 Cluster_653286 V1268139 S NA 0YZ82 Cluster_687953 V1268141 WHIB1 K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) 11UDY Cluster_692396 V1268147 ARAD map00040,map00053,map01100,map01120 G L-ribulose-5-phosphate 4-epimerase COG0235 Cluster_657413 V1268152 YLOV S dak2 domain fusion protein ylov COG1461 Cluster_661614 V1268153 map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_661615 V1268156 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_665827 V1268160 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_670130 V1268166 HELD map03420,map03430 L helicase COG3973 Cluster_715170 V1268179 T fha domain-containing protein COG1716 Cluster_674525 V1268183 Q AMP-binding enzyme COG1020 Cluster_678952 V1268188 HSDM V type I restriction-modification system COG0286 Cluster_711797 V1268192 INSI L transposase COG2826 Cluster_683521 V1268193 RPON map02020,map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG1508 Cluster_683522 V1268194 YBIT S ABC transporter COG0488 Cluster_725078 V1268196 FNI map00900,map01100,map01110 C Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) COG1577 Cluster_683523 V1268197 S Rib/alpha-like repeat 0YK85 Cluster_687954 V1268198 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_687955 V1268199 Q AMP-binding enzyme COG1020 Cluster_687956 V1268200 S NA 11NI8 Cluster_692397 V1268206 CPXR map02020 T Two component transcriptional regulator (Winged helix family COG0745 Cluster_793242 V1268208 S NA 0ZHU9 Cluster_2121 V1268214 P TonB-dependent Receptor Plug Domain protein COG4771 Cluster_71240 V1268217 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_80169 V1268218 FLIC map02020,map02040,map04626,map05132,map05134 N Flagellin COG1344 Cluster_91875 V1268219 map00730,map01100 H IA, variant 3 COG0637 Cluster_68904 V1268220 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_218499 V1268221 E, G Membrane COG0697 Cluster_9271 V1268223 U, W Inherit from COG: domain protein COG5295 Cluster_814 V1268225 S NA 0ZTYV Cluster_179521 V1268227 map00051 M glycosyltransferase, group 2 family protein COG0463 Cluster_45766 V1268229 S domain protein 0YF83 Cluster_439066 V1268230 S UPF0232 protein COG5512 Cluster_24189 V1268231 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_15464 V1268232 SCLAV_1560 map02010 P ABC transporter COG1122 Cluster_26371 V1268233 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG2812 Cluster_22872 V1268234 PEPN map00480,map01100 E aminopeptidase N COG0308 Cluster_34639 V1268238 S NA 11QSP Cluster_2633 V1268240 PULA G Glycogen debranching enzyme COG1523 Cluster_128202 V1268242 SECD map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) COG0342 Cluster_451100 V1268243 S Pfam:DUF2825 1286S Cluster_180355 V1268244 S Acyltransferase family 11XA1 Cluster_241191 V1268245 TAUB P abc transporter COG1116 Cluster_272424 V1268246 MRAZ S Cell division protein mraZ COG2001 Cluster_72168 V1268248 S NA 0Y74R Cluster_451101 V1268249 LRP K AsnC family transcriptional regulator COG1522 Cluster_225536 V1268250 S ABC transporter transmembrane protein 11H9G Cluster_85547 V1268253 SDAA map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase COG1760 Cluster_6321 V1268254 RV3193C S UPF0182 protein COG1615 Cluster_770172 V1268257 RGPD map02010 P abc transporter COG1134 Cluster_281743 V1268258 CODY K DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) COG4465 Cluster_599860 V1268259 L UPF0102 protein COG0792 Cluster_34359 V1268260 S NA 11UHB Cluster_12528 V1268262 S Lipase (class 3) 0ZJUJ Cluster_174552 V1268263 CZCD P cation diffusion facilitator family transporter COG1230 Cluster_220842 V1268264 S Membrane 0XQNE Cluster_183830 V1268265 GALE map00052,map00520,map01100,map01110 M udp-glucose 4-epimerase COG1087 Cluster_33527 V1268268 MALQ map00500,map01100 G 4-alpha-glucanotransferase COG1640 Cluster_177812 V1268269 INLJ map05150 M Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps 1215X Cluster_89522 V1268272 PIPD E Dipeptidase COG4690 Cluster_208386 V1268273 K Zinc finger helix-turn-helix protein, YgiT family 11YS4 Cluster_913512 V1268276 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_55996 V1268277 DACB map00550 M d-alanyl-d-alanine carboxypeptidase COG2027 Cluster_47295 V1268278 ILVB map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E acetolactate synthase COG0028 Cluster_449122 V1268281 RUVX L Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) COG0816 Cluster_443055 V1268282 YHGI O NifU domain protein COG0694 Cluster_352127 V1268284 S Colicin v production protein 126E4 Cluster_117012 V1268286 GLTA map00020,map00630,map00640,map01100,map01110,map01120,map01210,map01230 C citrate (Si)-synthase COG0372 Cluster_208387 V1268287 ANSA map00250,map00460,map00910,map01100,map01110 E L-asparaginase COG0252 Cluster_147312 V1268291 BMUL_5034 S Aminoglycoside phosphotransferase 0ZRQS Cluster_16610 V1268292 CSHA map03018 L ATP-dependent RNA helicase COG0513 Cluster_18602 V1268294 MRDA map00550 M penicillin-binding protein COG0768 Cluster_892 V1268295 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_2881 V1268296 MT3296 L helicase COG0210 Cluster_665828 V1268302 GATC map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0721 Cluster_77138 V1268304 THIM map00730,map01100 H 4-methyl-5-beta-hydroxyethylthiazole kinase COG2145 Cluster_208388 V1268307 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate (By similarity) COG0167 Cluster_405471 V1268308 PCP O Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) COG2039 Cluster_94709 V1268309 D Maf-like protein COG0424 Cluster_455054 V1268310 RUVX L Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) COG0816 Cluster_68226 V1268311 FABF3 map00061,map00780,map01100 I, Q synthase COG0304 Cluster_26033 V1268312 CADA P heavy metal translocating p-type ATPase COG2217 Cluster_13043 V1268313 M Glycosyl transferase, family 2 0XPRU Cluster_6412 V1268314 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_1332 V1268315 S NA 0YG6V Cluster_54303 V1268316 V abc transporter COG1132 Cluster_299495 V1268318 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_358809 V1268319 RDGB map00230,map00240,map01100 F Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) COG0127 Cluster_1223 V1268320 S NA 0YZ82 Cluster_42959 V1268321 map00051 M Transferase COG1216 Cluster_21079 V1268322 CBIO map02010 P abc transporter COG1122 Cluster_176156 V1268324 S repeat-containing protein COG0790 Cluster_345795 V1268325 S NA 11QRM Cluster_306598 V1268329 SUFC O feS assembly ATPase SufC COG0396 Cluster_124764 V1268330 L Integrase 0YTFQ Cluster_2579 V1268333 S NA 0YG6V Cluster_469444 V1268334 PTS36A map00052,map01100,map02060 G PTS System COG1762 Cluster_21410 V1268335 L HELICc COG4581 Cluster_678953 V1268338 V abc transporter permease protein COG0577 Cluster_382410 V1268339 RIMM S An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) 11YC3 Cluster_350623 V1268341 METI map02010 P ABC transporter, permease COG2011 Cluster_193509 V1268342 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_49165 V1268343 M Cell wall anchor domain protein 11Q8J Cluster_4434 V1268345 S NA 11QZ9 Cluster_3048 V1268346 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_22021 V1268348 RECG map03440 L ATP-dependent DNA helicase RecG COG1200 Cluster_101708 V1268349 TAUB map02010 P abc transporter COG1116 Cluster_3770 V1268355 S NA 0YG6V Cluster_135085 V1268356 FOLP map00790,map01100 H dihydropteroate synthase COG0294 Cluster_43324 V1268357 D atpase involved in chromosome 11NFV Cluster_389485 V1268359 ARGR K Regulates arginine biosynthesis genes (By similarity) COG1438 Cluster_166170 V1268360 4HBD map00650 C NAD-dependent 4-hydroxybutyrate dehydrogenase COG1454 Cluster_318479 V1268363 S Membrane 11NPN Cluster_142013 V1268364 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_45958 V1268365 S domain protein 0YF83 Cluster_859855 V1268366 S NA 0YFT4 Cluster_142014 V1268369 S Filamentation induced by cAMP protein fic COG3177 Cluster_250341 V1268370 BMUL_0473 S ABC transporter, permease COG4120 Cluster_504860 V1268371 S UPF0232 protein COG5512 Cluster_844341 V1268372 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_46732 V1268373 S pathogenesis 0XR1H Cluster_120631 V1268374 D DivIVA protein 0ZRXJ Cluster_398354 V1268375 LSPA map03060 M, U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) COG0597 Cluster_257760 V1268376 SUHB map00521,map00562,map01100,map01110,map04070 G inositol monophosphatase COG0483 Cluster_226656 V1268377 L TatD-related deoxyribonuclease COG0084 Cluster_264381 V1268378 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_16559 V1268379 S NA 0YDZN Cluster_107066 V1268380 S Esterase COG0627 Cluster_81352 V1268383 ASPC map00250,map00290,map01100,map01110,map01210,map01230 E Aminotransferase COG0436 Cluster_705539 V1268384 L DNA uptake protein and related DNA-binding COG1555 Cluster_546157 V1268385 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_43140 V1268387 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_175362 V1268388 S NA 0ZT2K Cluster_469445 V1268389 map00350,map00362,map00627,map00642,map00903,map01120 S acetyltransferase, (GNAT) family COG3981 Cluster_271089 V1268390 TYRA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydrogenase COG0287 Cluster_102808 V1268391 SP_1634 S Protein of unknown function (DUF2974) 0XSVF Cluster_439067 V1268393 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_32712 V1268394 S peptidase C10 11SDT Cluster_17145 V1268395 S NA 11QZ9 Cluster_583009 V1268396 S TPR repeat-containing protein COG0457 Cluster_7491 V1268397 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_316894 V1268398 COAX map00770,map01100 K Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) COG1521 Cluster_11027 V1268399 M Glycosyl transferase, family 2 0XPRU Cluster_507438 V1268400 S UPF0232 protein COG5512 Cluster_358810 V1268402 S NA 11WG4 Cluster_9810 V1268403 S NA 0YZ82 Cluster_674526 V1268404 SP_0275 L Addiction module antitoxin, RelB DinJ family COG3077 Cluster_414439 V1268405 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG1754 Cluster_76433 V1268407 CASA L crispr-associated protein 0XPA1 Cluster_443056 V1268408 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_10544 V1268410 S NA 0YZ82 Cluster_152067 V1268412 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_309330 V1268413 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_528991 V1268415 S Abortive infection protein AbiGI 11WH3 Cluster_427198 V1268416 map00240,map01100 Q Isochorismatase, hydrolase 11FZS Cluster_699393 V1268418 S NA 11H5S Cluster_211634 V1268419 M Glycosyl hydrolase, family 25 COG3757 Cluster_187343 V1268420 S (LipO)protein 11SHJ Cluster_51742 V1268421 CADA P p-type atpase COG2217 Cluster_407132 V1268423 ACPS map00770 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) COG0736 Cluster_281744 V1268424 BL01661 map05146 O proteinase inhibitor I4 serpin COG4826 Cluster_16879 V1268425 S Lipase (class 3) 0ZJUJ Cluster_43496 V1268426 PARE L DNA topoisomerase IV (Subunit B) COG0187 Cluster_22204 V1268427 YLBB V abc transporter permease protein COG0577 Cluster_58802 V1268430 map02010 V ABC transporter, ATP-binding permease protein COG1132 Cluster_60663 V1268432 M Inherit from NOG: Lpxtg-motif cell wall anchor domain protein 0Y6CS Cluster_17069 V1268433 S NA 0ZTYV Cluster_14744 V1268434 S NA 0YZ82 Cluster_332088 V1268435 S NA 0YEBS Cluster_108815 V1268436 map00051 M glycosyltransferase, group 2 family protein COG0463 Cluster_69620 V1268437 PTSI map02060 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) COG1080 Cluster_487417 V1268440 S NA 0ZYA7 Cluster_380630 V1268441 RPSD map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) COG0522 Cluster_370388 V1268442 S NA 11IYN Cluster_101157 V1268443 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_372021 V1268444 M Choline kinase COG4750 Cluster_715173 V1268445 S NA 0ZHU9 Cluster_785456 V1268446 YQEY S gatB Yqey COG1610 Cluster_683525 V1268448 RPSO map03010 J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) COG0184 Cluster_27783 V1268449 S NA 0ZTYV Cluster_327644 V1268452 S Membrane 11NPN Cluster_531824 V1268453 M Export protein COG1596 Cluster_108816 V1268454 RV2242 K Transcriptional regulator COG2508 Cluster_335103 V1268455 ORN map03008 A 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) COG1949 Cluster_323002 V1268456 GLUA map02010 E abc transporter atp-binding protein COG1126 Cluster_629340 V1268457 G PTS System COG1445 Cluster_629341 V1268458 CAS2 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) COG3512 Cluster_141286 V1268460 J Translation initiation factor IF-2, N-terminal region COG0532 Cluster_625640 V1268462 FECA P Receptor COG4772 Cluster_62095 V1268464 TRAG2 S conjugation system ATPase, TraG family 0XSHU Cluster_373643 V1268466 S Auxin Efflux Carrier COG0679 Cluster_135895 V1268467 S NA 0XNWW Cluster_131911 V1268468 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_510035 V1268469 SP_0161 K, T lytTr DNA-binding domain protein COG3279 Cluster_65701 V1268470 S domain protein 0YF83 Cluster_135896 V1268473 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_352128 V1268476 S Cbs domain protein COG0517 Cluster_309331 V1268477 S NA 0Z9X7 Cluster_254036 V1268478 CYCMA_0607 S transposase 11H93 Cluster_531825 V1268479 UMUC L DNA polymerase COG0389 Cluster_163715 V1268482 L site-specific recombinase, phage integrase family 0ZF8H Cluster_32570 V1268483 V ABC, transporter COG0577 Cluster_61282 V1268484 E Extracellular solute-binding protein, family 5 COG0747 Cluster_576635 V1268485 APPB map02010 P Binding-protein-dependent transport systems inner membrane component COG0601 Cluster_665829 V1268487 CRCB1 D Protein CrcB homolog COG0239 Cluster_34509 V1268488 NRDE map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_312296 V1268490 FTSX map02010 D Part of the ABC transporter FtsEX involved in cellular division (By similarity) COG2177 Cluster_97367 V1268494 S domain protein 0XS27 Cluster_492251 V1268496 YCCS S membrane COG1289 Cluster_36877 V1268498 L DNA helicase COG1112 Cluster_284526 V1268502 S Aminoglycoside phosphotransferase 0XP56 Cluster_355452 V1268503 P tonB-dependent Receptor COG1629 Cluster_117013 V1268504 M glycosyl transferase group 1 0ZVDW Cluster_39801 V1268505 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_318480 V1268507 NQRC C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG2869 Cluster_307914 V1268508 THIC map00730,map01100 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) COG0422 Cluster_377124 V1268509 S FMN_bind 12BR0 Cluster_326082 V1268510 H thiF family COG0476 Cluster_433074 V1268512 RBFA J Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) COG0858 Cluster_649203 V1268513 YCLK T Histidine kinase 0XNMH Cluster_437045 V1268514 YQEG S had superfamily (subfamily IIIa) phosphatase COG2179 Cluster_136704 V1268515 map00400,map01100,map01110,map01230 S 3-dehydroquinate synthase 11ZZI Cluster_355453 V1268516 ISCU C SUF system FeS assembly protein COG0822 Cluster_145738 V1268517 MANA map00051,map00520,map01100,map01110 G mannose-6-phosphate isomerase COG1482 Cluster_183831 V1268519 GSIA map02010 E, P ABC transporter COG0444 Cluster_268438 V1268522 ENGB S Necessary for normal cell division and for the maintenance of normal septation (By similarity) COG0218 Cluster_832554 V1268523 S Membrane 0XQXB Cluster_295479 V1268524 TRAJ S conjugative transposon 0XP5P Cluster_372022 V1268525 ORFL L transposase COG2826 Cluster_540297 V1268526 S SusD family 0XR6V Cluster_183832 V1268528 V type i restriction COG0732 Cluster_384179 V1268529 PNCA map00760,map01100 Q isochorismatase COG1335 Cluster_60664 V1268531 S domain protein 0YF83 Cluster_255242 V1268535 TRML map04122 J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) COG0219 Cluster_338181 V1268536 YBHL S Membrane COG0670 Cluster_344176 V1268538 YAAA L UPF0246 protein COG3022 Cluster_246521 V1268541 map02010 P extracellular solute-binding protein COG1840 Cluster_176971 V1268544 K Transcriptional regulator COG1609 Cluster_497250 V1268545 S lysozyme 0YC6U Cluster_145739 V1268546 S Membrane 0ZQP3 Cluster_233736 V1268547 PERMEASE S permease COG0701 Cluster_63469 V1268548 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_64579 V1268551 OATA I Acyl-transferase COG1835 Cluster_478065 V1268553 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins COG0706 Cluster_377125 V1268555 S NA 0ZZWZ Cluster_471606 V1268556 ANSA map00250,map00460,map00910,map01100,map01110 E L-asparaginase COG0252 Cluster_300885 V1268558 D Conjugative transposon protein TraA 0Y9K3 Cluster_586203 V1268562 CAS2 L CRISPR-associated protein cas2 11VHR Cluster_72169 V1268567 S NA 0YZ82 Cluster_499911 V1268570 S NA 0ZHU9 Cluster_77503 V1268571 YDIF S ABC transporter, ATP-binding protein COG0488 Cluster_683526 V1268572 RPSN map03010 J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) COG0199 Cluster_728392 V1268573 T Transcription regulator 101GZ Cluster_629342 V1268574 G Aamy_C COG1523 Cluster_329130 V1268575 RPSE map03010 J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) COG0098 Cluster_80978 V1268578 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_358811 V1268587 S haloacid dehalogenase-like hydrolase COG0561 Cluster_149602 V1268588 M Sortase family COG3764 Cluster_271090 V1268590 V abc transporter COG1136 Cluster_492252 V1268592 ACD map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I Acyl-coa dehydrogenase COG1960 Cluster_492253 V1268593 S NA 0ZHU9 Cluster_298225 V1268594 SUFC O feS assembly ATPase SufC COG0396 Cluster_194441 V1268596 S relaxase mobilization nuclease domain protein 0XNXG Cluster_250342 V1268598 S membrAne 0YEM5 Cluster_633179 V1268599 YLBN S Nucleic acid-binding protein COG1399 Cluster_821001 V1268600 S NA 0ZUS1 Cluster_90435 V1268601 THIE map00730,map01100 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) COG0422 Cluster_224365 V1268602 ASPB K Transcriptional regulator COG1167 Cluster_441061 V1268603 RIMI S ribosomal-protein-alanine acetyltransferase COG0456 Cluster_762502 V1268609 DCUB map02020 O Anaerobic c4-dicarboxylate transporter COG2704 Cluster_573436 V1268612 S Addiction module antitoxin, RelB DinJ family 0XUTM Cluster_199914 V1268613 RND J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) COG0349 Cluster_171169 V1268614 METP P transporter COG0733 Cluster_876222 V1268615 BL00174 S NA 0YCB9 Cluster_99501 V1268617 map00680,map01120 S Phosphotransferase 0Y7VB Cluster_104616 V1268621 S NA 0YZ82 Cluster_107067 V1268627 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_715174 V1268628 S NA 0YG6V Cluster_637232 V1268629 TRAF2 S conjugative transposon protein TraF 0YJGM Cluster_219648 V1268630 TRAG2 S conjugation system ATPase, TraG family 0XSHU Cluster_382411 V1268631 THIO map00730 E glycine oxidase COG0665 Cluster_114901 V1268632 S endo-beta-N-acetylglucosaminidase 0ZPAJ Cluster_528993 V1268633 S NA 0Y02D Cluster_649204 V1268634 HYPC O Hydrogenase assembly chaperone hypC hupF COG0298 Cluster_112776 V1268635 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_344177 V1268637 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_852030 V1268639 UVRA2 map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_762503 V1268640 map00051,map00510,map01100 M group 2 family COG0463 Cluster_136705 V1268641 PROTEASE map05120 O peptidase COG0826 Cluster_121408 V1268643 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_200917 V1268645 SCLAV_1560 map02010 P ABC transporter COG1122 Cluster_252780 V1268651 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_130365 V1268654 U, W Pfam:YadA COG5295 Cluster_692399 V1268655 K Transcriptional Regulator, LuxR family 0Y1WM Cluster_526227 V1268656 T Histidine kinase COG0642 Cluster_355454 V1268658 S Relaxase mobilization nuclease 11PW0 Cluster_277745 V1268659 S Filamentation induced by cAMP protein fic COG3177 Cluster_163716 V1268661 GLYA map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01230 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) COG0112 Cluster_136706 V1268662 S NA 101UU Cluster_232477 V1268663 CYSK map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_168555 V1268664 S NA 0ZTYV Cluster_148844 V1268667 SUFD O feS assembly protein SufD COG0719 Cluster_592891 V1268672 S Membrane COG4485 Cluster_252781 V1268676 L snf2-related protein COG0553 Cluster_241192 V1268681 PDXS map00750 H Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) COG0214 Cluster_315371 V1268683 S Phospholipase Carboxylesterase 11SWE Cluster_176157 V1268687 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_292685 V1268688 C NADH flavin oxidoreductase NADH oxidase COG1902 Cluster_280415 V1268689 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_781365 V1268692 METQ map02010 P lipoprotein COG1464 Cluster_296828 V1268695 YLMH J s4 domain protein COG2302 Cluster_725079 V1268697 RPSS map03010 J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) COG0185 Cluster_510036 V1268699 S NA 0ZHU9 Cluster_166171 V1268700 map00360,map01120 C acyl-CoA reductase 0XPYP Cluster_167704 V1268701 L Phage integrase family COG4974 Cluster_475875 V1268703 RHLE map03018 L atp-dependent rna helicase COG0513 Cluster_174553 V1268706 YHGE S domain protein COG1511 Cluster_186504 V1268712 S NA 11YT1 Cluster_180356 V1268713 S NA 0YZ82 Cluster_185584 V1268721 S DNA-binding protein COG3943 Cluster_344178 V1268723 RPLD map03010 J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) COG0088 Cluster_344179 V1268724 RPLD map03010 J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) COG0088 Cluster_185585 V1268725 PRIA map03440 L Primosomal protein n' COG1198 Cluster_191686 V1268730 U, W Pfam:YadA COG5295 Cluster_358812 V1268731 CBC_0280 L Transposase COG3316 Cluster_649205 V1268733 S NA 0ZHU9 Cluster_209423 V1268734 S NA 0Z3Y8 Cluster_330539 V1268737 RPE map00030,map00040,map00710,map01100,map01110,map01120,map01230 G ribulose-phosphate 3-epimerase COG0036 Cluster_300886 V1268741 YLME F alanine racemase domain protein COG0325 Cluster_840319 V1268742 FAHA Q 5-carboxymethyl-2-hydroxymuconate Delta-isomerase (EC 5.3.3.10) COG0179 Cluster_341057 V1268745 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_247775 V1268748 M hydrolase, family 25 COG3757 Cluster_499912 V1268749 XFP map00030,map00680,map00710,map01100,map01120 G Phosphoketolase COG3957 Cluster_234923 V1268750 CYSK map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_219649 V1268754 S Family of unknown function (DUF490) 0Z0C5 Cluster_520578 V1268755 V Type I restriction modification DNA specificity domain protein COG0732 Cluster_220843 V1268756 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_220844 V1268757 T ATPase histidine kinase DNA gyrase B HSP90 domain protein 0XNMH Cluster_543226 V1268758 ISPB map00900,map01110 H synthase COG0142 Cluster_492254 V1268759 M Alpha beta hydrolase fold COG1073 Cluster_226657 V1268762 L Dna topoisomerase COG0550 Cluster_789464 V1268763 S NA 0YTRC Cluster_344180 V1268765 APPC map02010 P abc transporter, permease COG1173 Cluster_766455 V1268769 FSA map00030,map01100,map01110,map01120,map01230 G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) COG0176 Cluster_345796 V1268770 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E amino acid aminotransferase COG0115 Cluster_515335 V1268777 S NA 0YHXM Cluster_633181 V1268778 SILP P copper-exporting ATPase COG2217 Cluster_653289 V1268780 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_243910 V1268782 HSDM V type I restriction-modification system COG0286 Cluster_412573 V1268783 J sua5 ycio yrdc ywlc family protein COG0009 Cluster_243911 V1268784 M group 2 family 0XRCB Cluster_554972 V1268785 RPLQ map03010 J 50S ribosomal protein l17 COG0203 Cluster_367065 V1268786 ATPD map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG1394 Cluster_246522 V1268787 E, J, M Polynucleotide kinase 3 phosphatase COG1208 Cluster_246523 V1268789 P Membrane 0XNNV Cluster_281745 V1268791 S hydrolase COG0561 Cluster_309332 V1268792 PURM map00230,map01100,map01110 F phosphoribosylaminoimidazole synthetase COG0150 Cluster_443057 V1268795 DALK_0900 L transposase (IS4 family) protein 0XQ88 Cluster_447101 V1268801 S NA 0XTEF Cluster_330540 V1268802 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_267027 V1268805 S TPR repeat-containing protein COG0457 Cluster_268439 V1268806 M Cell wall binding repeat 2-containing protein COG2247 Cluster_552082 V1268808 S TRNA Guanine-N7-methyltransferase COG0220 Cluster_661616 V1268811 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_557891 V1268812 S NA 0ZHU9 Cluster_570208 V1268814 RPSK map03010 J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) COG0100 Cluster_272425 V1268817 HEMA map00860,map01100,map01110 H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) COG0373 Cluster_770175 V1268818 E, G EamA-like transporter family COG0697 Cluster_330541 V1268819 map00430,map00620,map00640,map00650,map00680,map00720,map01100,map01120 C phosphate COG0280 Cluster_657415 V1268821 XSEB map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) 121U6 Cluster_275109 V1268822 L DNA helicase COG1112 Cluster_384180 V1268826 S NA 0YFUK Cluster_298226 V1268830 CLPB O ATP-dependent chaperone protein ClpB COG0542 Cluster_755199 V1268836 S NA 0ZHU9 Cluster_793243 V1268837 S Pfam:DUF2825 1286S Cluster_546158 V1268839 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_528994 V1268841 MDH map00051,map01100 E Dehydrogenase COG1063 Cluster_385960 V1268849 map02010 P periplasmic binding protein COG0614 Cluster_300887 V1268850 PTPA map04974 E peptidase COG1506 Cluster_705542 V1268853 map00052,map00520,map01100,map01110 M Male sterility protein COG0451 Cluster_305218 V1268856 CADA P Cadmium-exporting ATPase COG2217 Cluster_596357 V1268865 S NA 0ZHU9 Cluster_313794 V1268869 YQEV J MiaB-like tRNA modifying enzyme COG0621 Cluster_313795 V1268873 PRFC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) COG4108 Cluster_389486 V1268877 UDK map00240,map00983,map01100 F uridine monophosphokinase COG0572 Cluster_319960 V1268886 RECG map03440 L ATP-dependent DNA helicase recg COG1200 Cluster_805364 V1268893 RPOE K RNA polymerase COG1595 Cluster_363627 V1268897 O ADP-ribosylglycohydrolase COG1397 Cluster_785462 V1268898 S NA 0ZHU9 Cluster_327645 V1268899 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_471607 V1268900 ALAR K transcriptional regulator AsnC family COG1522 Cluster_326083 V1268901 PURC map00230,map01100,map01110 F SAICAR synthetase COG0152 Cluster_362060 V1268904 S Cpl-7 lysozyme C-terminal domain 0XYXY Cluster_341058 V1268906 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_872120 V1268908 S NA 0ZHU9 Cluster_335104 V1268910 M glycosyltransferase group 2 family protein 0YW14 Cluster_338182 V1268911 S tetratricopeptide repeat 0YK8K Cluster_338183 V1268915 S NA 0Z34Z Cluster_793244 V1268916 S NA 0ZHU9 Cluster_365371 V1268918 COMEA L Competence protein COG1555 Cluster_342577 V1268919 map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aminotransferase COG0436 Cluster_504861 V1268923 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_344181 V1268924 YEII map00240 G kinase (PfkB family COG0524 Cluster_463154 V1268926 S tm2 domain-containing protein 12AVU Cluster_744954 V1268927 S NA 0ZHU9 Cluster_382412 V1268928 APT map00230,map01100 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) COG0503 Cluster_621842 V1268929 RPLS map03010 J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) COG0335 Cluster_589490 V1268931 CRCB S Protein CrcB homolog 0XUV1 Cluster_385961 V1268933 SCLAV_3163 P phosphate transport regulator COG1392 Cluster_705543 V1268934 LICD M licD family COG3475 Cluster_586204 V1268936 S NA 0ZHU9 Cluster_762507 V1268943 OORD map00020,map00720,map01100,map01120 C 4Fe-4S Ferredoxin, iron-sulfur binding domain protein COG1146 Cluster_872121 V1268945 RPLI map03010 J Binds to the 23S rRNA (By similarity) COG0359 Cluster_367066 V1268947 PLSY map00561,map00564,map01100 S Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) COG0344 Cluster_358813 V1268948 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_360481 V1268949 DOTG S Inherit from NOG: May mediate a process in spermatogenesis or may play a role in sex ratio distortion 11QYX Cluster_431061 V1268953 V LlaJI restriction endonuclease 103AJ Cluster_363628 V1268958 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_427199 V1268960 DPPC map02010 P ABC transporter COG1173 Cluster_421606 V1268962 S ser thr protein phosphatase family protein 11K47 Cluster_367067 V1268963 NNRD G carbohydrate kinase, YjeF related protein COG0063 Cluster_380631 V1268965 FBP map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120 G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 COG3855 Cluster_543228 V1268966 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III, delta subunit COG1466 Cluster_758705 V1268967 CLCAR_1091 T Histidine kinase COG0642 Cluster_670132 V1268968 RPRY map02020 T Transcriptional regulatory protein, C terminal COG0745 Cluster_391215 V1268971 S Relaxase mobilization nuclease 0Y9PG Cluster_534617 V1268972 ATPG map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) COG0224 Cluster_370390 V1268978 V restriction COG1401 Cluster_492255 V1268982 S NA 0ZHU9 Cluster_375354 V1268987 DCUB map02020 O Anaerobic c4-dicarboxylate transporter COG2704 Cluster_377126 V1268991 AROA map00400,map00401,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate synthase COG0128 Cluster_377127 V1268993 M Membrane 0XT9Z Cluster_377128 V1268995 S Clostripain family 0YH96 Cluster_380632 V1268999 CASA L crispr-associated protein 0XPA1 Cluster_380633 V1269000 RECG map03420,map03440 L transcriptioN-repair coupling factor COG1197 Cluster_382413 V1269002 BDP_1102 V abc transporter COG1136 Cluster_384181 V1269004 S Methyltransferase domain protein 11HQ9 Cluster_389487 V1269016 S NA 126VW Cluster_876227 V1269017 PYRR map00240,map01100 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) COG2065 Cluster_405472 V1269019 MT2607 map00330,map00480,map01100,map01110 E decarboxylase COG1982 Cluster_557893 V1269021 MREB D Rod shape-determining protein mreb COG1077 Cluster_718420 V1269023 S NA 0YX7E Cluster_461046 V1269032 map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase COG3958 Cluster_592892 V1269035 SSTT E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) COG3633 Cluster_419805 V1269036 ERYC E DegT DnrJ EryC1 StrS COG0399 Cluster_534618 V1269040 S NA 0ZHU9 Cluster_403653 V1269046 NIFS map00450,map00730,map01100,map04122 E cysteine desulfurase family protein COG0520 Cluster_405473 V1269049 YDDW M YngK protein COG1649 Cluster_567123 V1269050 ARGS map00970 J arginyL-tRNA synthetase COG0018 Cluster_412574 V1269060 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_414440 V1269065 AMYE map02010 G solute-binding protein COG1653 Cluster_625644 V1269073 S NA 0ZHU9 Cluster_416220 V1269077 SLGD_00062 S membrAne 11F2H Cluster_789465 V1269085 NRDB map00230,map00240,map00480,map01100,map04115 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_456989 V1269090 S NA 0ZHU9 Cluster_421607 V1269093 S NA 0XV6C Cluster_421608 V1269094 L DNA (cytosine-5-)-methyltransferase COG2189 Cluster_425263 V1269103 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG2812 Cluster_427200 V1269106 CYDB map00190,map01100,map02020 C cytochrome D ubiquinol oxidase subunit II COG1294 Cluster_699397 V1269109 HIMA L DNA-binding protein Hu 123YW Cluster_528995 V1269118 PATB map00270,map00450,map00920,map01100,map01110,map01230 E Aminotransferase class I and II COG1168 Cluster_433075 V1269122 YICC map03010 S YicC domain protein COG1561 Cluster_461047 V1269125 PNCA map00760,map01100 Q nicotinamidase COG1335 Cluster_852033 V1269126 RPMG map03010 J 50S ribosomal protein L33 COG0267 Cluster_443058 V1269128 S alpha-2-macroglobulin COG2373 Cluster_441062 V1269137 PURB map00230,map00250,map01100,map01110 F adenylosuccinate lyase COG0015 Cluster_458971 V1269140 S NA 11WQR Cluster_560943 V1269147 S peptidase M15 0Y4QW Cluster_621843 V1269152 S NA 0ZX1V Cluster_744956 V1269154 S NA 0ZHU9 Cluster_447102 V1269157 RECQ map03018 L ATP-dependent DNA helicase RecQ COG0514 Cluster_447103 V1269159 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_447104 V1269161 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_447106 V1269163 LGT M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 Cluster_618208 V1269164 S NA 0Z75A Cluster_447107 V1269166 AMS1 map00511 G hydrolase, family 38 COG0383 Cluster_708618 V1269170 S NA 11MEK Cluster_537509 V1269172 S NA 0ZHU9 Cluster_449123 V1269173 RPSA map00900,map01100,map01110,map03010 J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) COG0539 Cluster_499913 V1269174 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_734915 V1269175 S helix-turn-helix domain protein 122WR Cluster_449124 V1269176 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_456990 V1269180 APEA map00480,map01100 E M18 family aminopeptidase COG1362 Cluster_687961 V1269182 RPLO map03010 J Binds to the 23S rRNA (By similarity) COG0200 Cluster_453031 V1269184 PSAA map02010 P ABC transporter COG0803 Cluster_453032 V1269188 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_504863 V1269190 FTSA map04112 D This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) COG0849 Cluster_687962 V1269191 S Membrane 0XRRH Cluster_463155 V1269200 P TonB-dependent receptor Plug 0XQ9V Cluster_728396 V1269202 S NA 0ZHU9 Cluster_458972 V1269204 CYSK map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_458973 V1269205 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_463156 V1269215 RMUC S Dna recombination protein COG1322 Cluster_465236 V1269216 L Type III restriction-modification system methylase COG2189 Cluster_478066 V1269220 LSPA map03060 M, U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) COG0597 Cluster_465237 V1269222 M Outer membrane efflux protein COG1538 Cluster_480468 V1269224 PLSY map00561,map00564,map01100 S Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) COG0344 Cluster_603459 V1269227 THIJ S intracellular protease Pfpi family COG0693 Cluster_471608 V1269234 PEPP E peptidase, M24 COG0006 Cluster_731674 V1269236 PANE1 map00770,map01100,map01110 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) COG1893 Cluster_557894 V1269240 MVK map00900,map01100,map01110,map04146 I mevalonate kinase COG1577 Cluster_473703 V1269243 S NA 101UU Cluster_485124 V1269247 CAS3 L CRISPR-associated helicase, cas3 COG1203 Cluster_540298 V1269254 S NA 0ZHU9 Cluster_777565 V1269256 NRDG O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) COG0602 Cluster_478067 V1269260 ATPH map00190,map00195,map01100 C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) COG0712 Cluster_480469 V1269263 INSI L transposase COG2826 Cluster_683530 V1269271 RBO C Superoxide reductase COG2033 Cluster_485125 V1269276 GMD map00051,map00520,map01100 M Gdp-mannose 4,6-dehydratase COG1089 Cluster_487418 V1269278 CTPA M Peptidase, S41 family COG0793 Cluster_489762 V1269284 PPDK map00620,map00710,map01100,map01120 G Pyruvate phosphate dikinase COG0574 Cluster_499915 V1269285 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_738251 V1269288 S NA 0ZHU9 Cluster_576639 V1269289 S TM2 domain 0XUUS Cluster_557895 V1269291 RUMG map02010 S Inherit from COG: permease COG4200 Cluster_494744 V1269292 map00310,map00780,map01100 E Peptidase, S9A B C family, catalytic domain protein COG1506 Cluster_625645 V1269293 PORU S NA 0XPE4 Cluster_494745 V1269295 S radical SAM domain protein 125RF Cluster_497252 V1269296 S ATP GTP Binding Protein 0XSDB Cluster_497253 V1269298 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_699399 V1269302 YFIO M outer membrane assembly lipoprotein yfio 0ZZRH Cluster_499916 V1269305 SUN_0728 L transposase (IS4 family) protein 12CNV Cluster_504865 V1269310 S von Willebrand factor type 11R5D Cluster_625646 V1269313 RPSM map03010 J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits COG0099 Cluster_586205 V1269331 T Universal stress COG0589 Cluster_518004 V1269332 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_900903 V1269333 SECG map03060,map03070 U Preprotein translocase, subunit SecG 0ZZ0X Cluster_523322 V1269337 map00473,map00550,map01100 S Pasta domain containing protein 120IY Cluster_817131 V1269344 L mutator MutT protein COG0494 Cluster_523323 V1269345 S NA 0ZTYV Cluster_531830 V1269356 F ATP cone domain COG1328 Cluster_534621 V1269361 FEMA map00550,map01100 V Methicillin resistance protein COG2348 Cluster_657419 V1269363 K RNA Polymerase COG1595 Cluster_534622 V1269368 S NA 0ZTYV Cluster_534623 V1269369 S Inherit from COG: leucine Rich Repeat COG4886 Cluster_586206 V1269372 S NA 0ZHU9 Cluster_540299 V1269374 S Membrane COG4299 Cluster_540300 V1269379 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_560945 V1269382 V type i restriction COG0732 Cluster_540301 V1269384 S NA 0ZHU9 Cluster_859870 V1269387 LOLA M outer membrane lipoprotein carrier protein LolA 11PS8 Cluster_546159 V1269392 S Phosphotransferase enzyme family COG3178 Cluster_621844 V1269393 K Transcriptional regulator COG0789 Cluster_554973 V1269399 S NA 0YNFS Cluster_554974 V1269400 S relaxase mobilization nuclease domain protein 0XNXG Cluster_618209 V1269402 GAPA map00010,map01100,map01110,map01120,map01230,map04066,map05010 G Glyceraldehyde-3-phosphate dehydrogenase, type I COG0057 Cluster_576640 V1269407 CPSY K Transcriptional regulator COG0583 Cluster_748301 V1269409 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_560947 V1269411 FBA map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01230 G Fructose-1,6-bisphosphate aldolase, class II COG0191 Cluster_560948 V1269412 HFLX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COG2262 Cluster_560949 V1269413 S Family of unknown function (DUF490) 0Z0C5 Cluster_576641 V1269415 S NA 0ZHMR Cluster_560950 V1269416 S (LipO)protein 0XSYT Cluster_567124 V1269427 CYDD map02010 V ABC, transporter COG4988 Cluster_570210 V1269433 U, W Pfam:YadA COG5295 Cluster_570212 V1269437 INLJ map05150 M Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps 1215X Cluster_573437 V1269442 KIPA E Allophanate hydrolase subunit 2 COG1984 Cluster_637238 V1269450 S Protein of unknown function (DUF524) COG1700 Cluster_579772 V1269461 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_589492 V1269476 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_599863 V1269477 K Peptidase S24-like protein COG2932 Cluster_589493 V1269478 L Domain protein COG0507 Cluster_589494 V1269479 S NA 0ZTN9 Cluster_592894 V1269484 S NA 0YZ82 Cluster_844357 V1269490 OMPH M outer membrane chaperone Skp (OmpH) 11GII Cluster_596360 V1269492 GATB map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 Cluster_596361 V1269493 S NA 0XQ5J Cluster_596363 V1269496 PROV map02010 E ABC transporter COG1125 Cluster_596364 V1269497 S Phosphotransferase enzyme family COG3178 Cluster_596365 V1269500 SSCG_01435 E ABC transporter COG0765 Cluster_683531 V1269506 P phosphate-selective porin O and P 12BMY Cluster_603461 V1269510 YAZA L domain protein COG2827 Cluster_603462 V1269511 NIFS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_610730 V1269518 S NA 0ZTYV Cluster_607082 V1269519 T Universal stress protein COG0589 Cluster_705545 V1269524 SP_1473 S UPF0291 protein COG4224 Cluster_610732 V1269526 MALG map02010 P ABC transporter, permease COG3833 Cluster_614456 V1269530 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_614457 V1269531 S Pfam:DUF1893 123Z7 Cluster_614458 V1269533 L integrase family 0XRS7 Cluster_674531 V1269537 S Membrane 0XR5T Cluster_618210 V1269543 PTSG map00010,map00500,map00520,map02060 G PTS System COG1264 Cluster_618211 V1269544 map02010 P Periplasmic binding protein COG0614 Cluster_618212 V1269545 S Uncharacterised protein family (UPF0104) 0Y29R Cluster_621845 V1269546 GLPF G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) COG0580 Cluster_824968 V1269547 NRDI F Probably involved in ribonucleotide reductase function (By similarity) COG1780 Cluster_621849 V1269560 YLOV S dak2 domain fusion protein ylov COG1461 Cluster_621850 V1269562 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_645109 V1269565 FEPC map02010 P ABC, transporter COG1120 Cluster_629345 V1269569 SASC S surface protein 11FPX Cluster_633183 V1269573 LEVR K Sigma-54 interaction domain protein COG3933 Cluster_633184 V1269574 THIG map00730,map01100 H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) COG2022 Cluster_645110 V1269577 PARE L DNA topoisomerase IV (Subunit B) COG0187 Cluster_683532 V1269586 HSDR V Type I Restriction COG0610 Cluster_649206 V1269602 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_848243 V1269606 DEAD map03018 L dead deah box COG0513 Cluster_649208 V1269610 OPPF map02010 E (ABC) transporter COG4608 Cluster_649209 V1269612 SSCG_00971 S integral membrane transport protein 0XP2U Cluster_653292 V1269614 TRXB map00240,map00450 O thioredoxin reductase COG0492 Cluster_711809 V1269621 S Phage portal protein COG4695 Cluster_657422 V1269627 S NA 0ZHU9 Cluster_657423 V1269630 S Protein of unknown function (DUF3256) 11UJE Cluster_661617 V1269638 map00500,map01100 G Glycogen debranching enzyme COG3408 Cluster_696125 V1269640 map00051 M Glycosyl transferase (Group 1 COG0438 Cluster_665833 V1269643 PORG map00020,map00720,map01100,map01120 C oxidoreductase COG1014 Cluster_665834 V1269645 S domain protein 0YF83 Cluster_705546 V1269650 MRP D ATP-binding protein COG0489 Cluster_670136 V1269656 FOLE map00790,map01100 H GTP cyclohydrolase i COG0302 Cluster_670137 V1269657 S NA 101UU Cluster_670138 V1269658 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_674532 V1269659 SECG map03060,map03070 U Preprotein translocase SecG subunit 123GJ Cluster_708619 V1269661 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_687965 V1269662 S NA 0XZUM Cluster_674533 V1269664 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_674534 V1269665 DALK_0900 L transposase (IS4 family) protein 0XQ88 Cluster_674535 V1269667 AGUB map00330,map01100 S hydrolase, carbon-nitrogen family COG0388 Cluster_678956 V1269668 S LRR COG4886 Cluster_674536 V1269672 S ATPase (AAA COG1373 Cluster_678957 V1269674 TYPA T gtp-binding protein typa COG1217 Cluster_683534 V1269679 UMUC L DNA polymerase COG0389 Cluster_683537 V1269687 RNHB map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0164 Cluster_683538 V1269688 map00680,map01120 C oxidoreductase COG1902 Cluster_687967 V1269690 RNPA J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) COG0594 Cluster_770186 V1269692 RPSP map03010 J 30s ribosomal protein S16 COG0228 Cluster_687969 V1269693 GATC2 map00052,map01100,map02060 G PTS system, galactitol-specific IIc component COG3775 Cluster_687970 V1269694 T ATPase histidine kinase DNA gyrase B HSP90 domain protein 0XNMH Cluster_711810 V1269696 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_6097 V1269710 U, W Domain-Containing protein COG5295 Cluster_49590 V1269711 MOD map00340,map00350,map00624,map01120 L DNA methylase COG2189 Cluster_441064 V1269715 map00051,map01100,map02060 G PTS System COG1762 Cluster_9303 V1269716 G hydrolase family 16 COG2273 Cluster_71241 V1269718 map00500,map04151,map04910 M synthase COG0438 Cluster_20615 V1269719 map00500,map01100,map01110 G, M phosphorylase COG0438 Cluster_191687 V1269720 DUSB J Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_33391 V1269721 IRP P tonB-dependent Receptor COG1629 Cluster_148105 V1269722 SPMB S nucleoside recognition domain protein COG2715 Cluster_91876 V1269723 M polysaccharide biosynthesis protein 0XPJ8 Cluster_36003 V1269724 S peptidase 0XPBV Cluster_573438 V1269725 S NA 124XV Cluster_50366 V1269726 DEAD map03018 L dead deah box COG0513 Cluster_12797 V1269727 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_242565 V1269728 G aggregation factor core protein MAFp3, isoform C COG2931 Cluster_34360 V1269729 O m6 family metalloprotease domain protein COG4412 Cluster_85923 V1269731 GPMI map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0696 Cluster_370391 V1269732 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_40548 V1269733 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_738254 V1269734 RPST map03010 J Binds directly to 16S ribosomal RNA (By similarity) 1220Z Cluster_507 V1269735 S NA 0YZ82 Cluster_552084 V1269736 S NA 12D5B Cluster_653295 V1269737 S NA 1258Z Cluster_4249 V1269738 C FMN-binding domain protein COG3976 Cluster_540302 V1269739 S NA 0ZZ7Z Cluster_119147 V1269740 YOCR P transporter COG0733 Cluster_252782 V1269741 L Membrane COG4905 Cluster_37331 V1269744 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_172909 V1269745 LPXB map00540,map01100 M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) COG0763 Cluster_312297 V1269746 SOJ D Chromosome Partitioning Protein COG1192 Cluster_28356 V1269747 SPOT map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_17813 V1269748 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_88131 V1269749 map03440 L ATP-dependent exodnase (exonuclease v) COG0507 Cluster_378912 V1269750 S NA 122NP Cluster_269784 V1269752 ETFB map00910 C Electron transfer flavoprotein COG2086 Cluster_163717 V1269753 MSCS M Mechanosensitive ion channel COG0668 Cluster_755 V1269754 SOV S Gliding motility-related protein 0XPT8 Cluster_398355 V1269755 RUVA map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) COG0632 Cluster_391216 V1269756 K RNA polymerase 11UU1 Cluster_257761 V1269758 LACC map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G tagatose-6-phosphate kinase COG1105 Cluster_280416 V1269759 RFBD map00521,map00523,map01100,map01110 M Dtdp-4-dehydrorhamnose reductase COG1091 Cluster_13251 V1269760 PITRM1 O peptidase COG1026 Cluster_190764 V1269762 map00860,map01100,map01110 H Uroporphyrinogen decarboxylase COG0407 Cluster_394837 V1269763 S Signal transduction histidine kinase, lyts 11GMZ Cluster_291342 V1269764 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_391218 V1269765 LEPB map03060 U Signal peptidase i COG0681 Cluster_482798 V1269766 LSPA map03060 M, U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) COG0597 Cluster_201902 V1269767 S NA 10TF5 Cluster_200918 V1269768 TIG O Peptidyl-prolyl cis-trans isomerase COG0545 Cluster_239908 V1269769 TIG O Peptidyl-prolyl cis-trans isomerase COG0545 Cluster_69273 V1269771 UDK map00240,map00983,map01100 F uridine kinase COG0572 Cluster_48965 V1269772 KORA map00020,map00720,map01100,map01120 C 2-oxoacid acceptor oxidoreductase, alpha subunit COG1014 Cluster_194442 V1269773 KORB map00020,map00720,map01100,map01120 C 2-oxoglutarate ferredoxin oxidoreductase subunit beta COG1013 Cluster_142015 V1269774 PRTC map05120 O collagenase COG0826 Cluster_90920 V1269775 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_107648 V1269777 ELI_1314 S NA 0XT3I Cluster_225537 V1269779 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG0582 Cluster_185586 V1269781 S (LipO)protein 11SHJ Cluster_63185 V1269782 V ABC transporter COG1132 Cluster_261708 V1269783 PPNK map00760,map01100 G Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) COG0061 Cluster_135897 V1269784 M Glycosyl transferase (Group 1 0XSCX Cluster_418020 V1269785 SLGD_00062 S membrAne 11F2H Cluster_335105 V1269786 Q Methyltransferase COG0500 Cluster_489763 V1269787 C NADH dehydrogenase 12BDE Cluster_36549 V1269788 M Cell wall binding repeat 2-containing protein 12D0J Cluster_252783 V1269789 I Lipid kinase, YegS Rv2252 BmrU family COG1597 Cluster_103442 V1269790 S tetratricopeptide 11P8K Cluster_79162 V1269791 YJGR S ATP-binding protein COG0433 Cluster_189910 V1269793 MUTY map03410 L a g-specific adenine glycosylase COG1194 Cluster_264382 V1269794 MREC M Rod shape-determining protein mreC COG1792 Cluster_35049 V1269795 MRDA map00550 M Penicillin-binding protein 2 COG0768 Cluster_3049 V1269796 S NA 11MTE Cluster_38141 V1269797 DSBD O Thiol disulfide interchange protein COG4232 Cluster_169483 V1269798 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG2812 Cluster_305219 V1269799 BIRA map00780,map01100,map02010 H biotin acetyl-CoA-carboxylase ligase COG0340 Cluster_489078 V1026803 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_486806 V1026804 G Major Facilitator 0XPHU Cluster_489079 V1026806 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_486807 V1026807 S membrane 11JQ4 Cluster_609634 V1026808 NUPG G nucleoside 176TY@proNOG Cluster_486808 V1026809 BMUL_0353 M YD repeat protein COG3209 Cluster_486809 V1026810 NRDE map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_605962 V1026811 DCUD C C4-dicarboxylate transporter COG3069 Cluster_691198 V1026813 YIHR G Aldose-1-epimerase COG2017 Cluster_647930 V1026814 GG9_0947 K LysR family Transcriptional regulator 16PRC@proNOG Cluster_812260 V1026817 RPMC map03010 J 50S ribosomal protein L29 1226R Cluster_816078 V1026819 L transposase COG3039 Cluster_489080 V1026823 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_652028 V1026824 PYRB map00240,map00250,map01100 F aspartate transcarbamylase COG0540 Cluster_870948 V1026825 PYRC map00240,map01100 F dihydroorotase EC 3.5.2.3 COG0044 Cluster_489081 V1026826 YDEP map00630,map00680,map01100,map01120 C Oxidoreductase alpha (molybdopterin) subunit COG0243 Cluster_489082 V1026827 HSDR V type I restriction-modification system COG0610 Cluster_489083 V1026833 LACR K DeoR family transcriptional regulator COG1349 Cluster_701631 V1026834 LYSP E permease COG0833 Cluster_560083 V1026835 DIVIC D Septum formation initiator COG2919 Cluster_489084 V1026836 ATPH map00190,map00195,map01100 C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) COG0712 Cluster_494063 V1026837 S NA 0XTK8 Cluster_489085 V1026839 DACB map00550 M d-alanyl-d-alanine carboxypeptidase COG2027 Cluster_489086 V1026842 S Ragb susd domain-containing protein 0XQ8A Cluster_504200 V1026844 map05132 K Transcriptional regulator COG1959 Cluster_519840 V1026846 map00730,map01100 H IA, variant 3 COG0637 Cluster_643916 V1026847 ISPE map00900,map01100,map01110 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COG1947 Cluster_489087 V1026848 map02010 E ABC, transporter COG3842 Cluster_489088 V1026849 GLGX map00500,map01100,map01110 G Glycogen debranching enzyme COG1523 Cluster_489089 V1026850 E Sodium:solute symporter family COG0591 Cluster_491613 V1026853 BMUL_1405 P phosphate transport regulator COG1392 Cluster_491614 V1026855 MT0808 S Inherit from COG: deacetylase COG3233 Cluster_504201 V1026856 SRFC S virulence COG4458 Cluster_491615 V1026857 M NA 0YHI1 Cluster_489090 V1026858 MCPU map02020,map02030 T Methyl-accepting chemotaxis sensory transducer COG0840 Cluster_839051 V1026859 METB map00260,map00270,map00450,map00920,map01100,map01110,map01230 E Cystathionine gamma-synthase COG0626 Cluster_545260 V1026860 YDII Q thioesterase Superfamily protein COG2050 Cluster_491616 V1026861 map00561,map01100 S Triacylglycerol lipase COG1075 Cluster_819745 V1026862 YCFH L Hydrolase, tatD family COG0084 Cluster_489091 V1026868 S NA 1CA7G@tenNOG Cluster_491617 V1026870 map00621,map00624,map00626,map01100,map01120 C FAD binding domain COG0654 Cluster_511902 V1026872 CAS1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) COG1518 Cluster_491619 V1026873 UBIE map00130,map01100,map01110 H Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) COG2226 Cluster_605963 V1026874 P multidrug resistance protein 125AJ Cluster_554137 V1026875 COPA map00053,map01100 Q Multicopper oxidase COG2132 Cluster_491620 V1026879 GLPD map00564 C Glycerol-3-phosphate dehydrogenase COG0578 Cluster_701633 V1026880 T positive regulator of sigmaE, RseC MucC 11VI5 Cluster_491621 V1026881 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_598866 V1026882 S Cupin 2, conserved barrel domain protein COG1917 Cluster_710849 V1026883 Q Phytanoyl-CoA dioxygenase COG5285 Cluster_854712 V1026884 J endoribonuclease L-psp COG0251 Cluster_620766 V1026886 PGN_0950 V ABC transporter, ATP-binding protein COG1132 Cluster_491623 V1026887 S NA 0ZHVH Cluster_799949 V1026888 S NA 0ZHU9 Cluster_491625 V1026896 YOAA L helicase COG1199 Cluster_539544 V1026897 GLTS E Sodium Glutamate Symporter COG0786 Cluster_710850 V1026898 HUP L DNA-binding protein COG0776 Cluster_727390 V1026900 XSA map00520,map01110 G Alpha-N-arabinofuranosidase (EC 3.2.1.55) COG3534 Cluster_733956 V1026901 P trap transporter solute receptor taxi family COG2358 Cluster_494064 V1026902 P TonB-dependent receptor Plug 0XNPQ Cluster_743962 V1026903 S Protein of unknown function (DUF1367) 17PDE@proNOG Cluster_867082 V1026904 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_843197 V1026905 FTSA map04112 D This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) COG0849 Cluster_491626 V1026907 FADD2 map00071,map01100,map03320,map04146,map04920 Q Long-chain-fatty-acid-CoA ligase COG0318 Cluster_491628 V1026909 PILY1-1 N, U Biogenesis protein COG3419 Cluster_491629 V1026910 S NA 11R2V Cluster_575688 V1026912 map00790,map01100 H FolB COG1539 Cluster_769194 V1026913 YLQC S UPF0109 protein COG1837 Cluster_562986 V1026918 RPSH map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) COG0096 Cluster_843198 V1026919 PSD map00564,map01100 I Phosphatidylserine decarboxylase proenzyme COG0688 Cluster_883260 V1026920 ILVC map00290,map00770,map01100,map01110,map01210,map01230 E Alpha-keto-beta-hydroxylacyl reductoisomerase COG0059 Cluster_494065 V1026921 AAVE_2884 S NA 16ZPM@proNOG Cluster_494067 V1026923 S integral membrane protein COG0628 Cluster_605964 V1026928 S PGAP1-like protein 1751F@proNOG Cluster_494068 V1026929 P TonB dependent receptor 0Y9KS Cluster_494069 V1026930 BAPA map02010 V ABC, transporter COG1132 Cluster_747376 V1026934 FABF map00061,map00780,map01100 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) COG0304 Cluster_494070 V1026935 THIC map00730,map01100 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) COG0422 Cluster_494071 V1026936 RPSA map00900,map01100,map01110,map03010 J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) COG0539 Cluster_539545 V1026939 DKGA-1 map00051,map00363,map00591,map00625,map00650,map01100,map01120 C reductase COG0656 Cluster_494072 V1026941 EXBB map01120 U MotA TolQ exbB proton channel COG0811 Cluster_698536 V1026943 ISPD map00900,map01100,map01110 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COG1211 Cluster_858515 V1026946 RPON map02020,map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG1508 Cluster_867083 V1026947 E Amino acid or sugar ABC transport system, permease protein COG4603 Cluster_494073 V1026948 S Membrane 0XTQ0 Cluster_494074 V1026949 COBJ map00860,map01100 H Precorrin-3B C17-methyltransferase COG2243 Cluster_819746 V1026950 map02010 E ABC transporter COG0410 Cluster_698537 V1026951 map02010 E ABC transporter COG0411 Cluster_673160 V1026954 GSPD map03070 U general secretion pathway protein D COG1450 Cluster_496560 V1026956 S Lpxtg-motif cell wall anchor domain protein 0XQBH Cluster_617012 V1026957 WBPC I Acyl-transferase COG1835 Cluster_754191 V1026960 V ABC transporter COG1132 Cluster_631976 V1026962 map03070 U type IV secretory pathway VirB4 COG3451 Cluster_496561 V1026963 L Resolvase COG1961 Cluster_714269 V1026965 SSPB S stringent starvation protein b COG2969 Cluster_496562 V1026966 L DNA helicase COG1112 Cluster_747377 V1026969 SECD map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) COG0342 Cluster_494077 V1026970 RSEP map04112 M Membrane-associated zinc metalloprotease COG0750 Cluster_569269 V1026971 PROY E amino acid COG1113 Cluster_496564 V1026974 CAFA map03018 J ribonuclease COG1530 Cluster_548302 V1026975 LSPA map03060 U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) 11G1Y Cluster_572464 V1026978 map02020 V ABC transporter, ATP-binding protein COG1136 Cluster_496566 V1026979 LACR K DeoR family transcriptional regulator COG1349 Cluster_496567 V1026980 ERUM0430 map00190 G, M Nad-dependent epimerase dehydratase COG0702 Cluster_496568 V1026981 T Hybrid Histidine Kinase 16PBK@proNOG Cluster_499218 V1026985 LYTS map02020 T Histidine kinase COG3275 Cluster_496570 V1026988 VRGS M Rhs element vgr protein COG3501 Cluster_496572 V1026990 LPXC map00061,map00540,map01100 M involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) COG0774 Cluster_585233 V1026994 L NA 11GDS Cluster_496573 V1026995 L integrase family 175MM@proNOG Cluster_499220 V1026999 RPRY map02020 T Transcriptional regulatory protein, C terminal COG0745 Cluster_499221 V1027000 S Type II DNA modification methyltransferase 0ZM02 Cluster_34510 V1269803 L Domain protein COG0507 Cluster_265710 V1269804 UBIA H Prenyltransferase COG0382 Cluster_51743 V1269805 YBIP S Sulfatase COG2194 Cluster_126110 V1269806 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_287374 V1269807 LICD M licD family COG3475 Cluster_27585 V1269808 MUTS2 map03430 L muts2 protein COG1193 Cluster_161226 V1269809 map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G, K ROK family COG1940 Cluster_47296 V1269810 BGLF map02060 G pts system COG2190 Cluster_138259 V1269811 CAPA M Capsule synthesis protein COG2843 Cluster_467335 V1269812 S NA 11QA3 Cluster_201903 V1269813 POXB map00620,map01100 E acetolactate synthase COG0028 Cluster_429086 V1269814 LCTO map00620,map01100 C Dehydrogenase COG1304 Cluster_98981 V1269815 ASCB map00010 G Glycosyl hydrolase family 1 COG2723 Cluster_252784 V1269816 BCRA map02010 V ABC transporter COG1131 Cluster_33755 V1269817 METE map00270,map00450,map01100,map01110,map01230 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) COG0620 Cluster_370392 V1269819 S acetyltransferase, (GNAT) family 123Q6 Cluster_195318 V1269820 PHAE S Poly(R)-hydroxyalkanoic acid synthase, class III, PhaE subunit 10XAY Cluster_161227 V1269821 L Integrase COG0582 Cluster_306600 V1269828 S NA 17VWE@proNOG Cluster_137494 V1269829 DCM map04112 L DNA Methylase COG1475 Cluster_179522 V1269830 PEAB S radical SAM domain protein COG0641 Cluster_372023 V1269834 S NA 0YE9N Cluster_1254 V1269836 S Cell surface protein 0ZXQA Cluster_79487 V1269837 M cell wall-binding protein COG2247 Cluster_339606 V1269838 C nitroreductase COG0778 Cluster_305220 V1269840 NAGB map00520,map01100,map01110 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COG0363 Cluster_12999 V1269841 O Peptidase, M16 COG0612 Cluster_71242 V1269842 FUMB map00020,map00720,map01100,map01110,map01120 C fumarate COG1951 Cluster_25804 V1269843 P tonB-dependent Receptor 0XPDR Cluster_21854 V1269844 S Membrane 0XQXB Cluster_55997 V1269845 TYPA T gtp-binding protein typa COG1217 Cluster_507440 V1269846 FOLK map00790,map01100 H 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase COG0801 Cluster_92372 V1269847 ALGI M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_324584 V1269848 XTH map03410 L Exodeoxyribonuclease III COG0708 Cluster_280417 V1269849 S sporulation and cell division repeat protein 12AK5 Cluster_178654 V1269850 RLUD J Pseudouridine synthase COG0564 Cluster_262999 V1269851 S NA 0XSIN Cluster_276437 V1269852 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0847 Cluster_2954 V1269853 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_463157 V1269854 TRPP S tryptophan transport protein 11UPK Cluster_451104 V1269855 YACP J Tetracycline resistance protein COG3688 Cluster_401860 V1269856 RNHA map03030 S ribonuclease COG3341 Cluster_377129 V1269857 T cyclic nucleotide-binding domain protein COG0664 Cluster_69274 V1269858 HCP C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) COG1151 Cluster_443060 V1269859 J acetyltransferase, (GNAT) family COG1670 Cluster_113515 V1269860 V Mate efflux family protein COG0534 Cluster_59352 V1269861 KATA map00380,map00630,map01110,map04146,map05014 P catalase COG0753 Cluster_239909 V1269862 map00120,map00121,map01100 M Choloylglycine hydrolase COG3049 Cluster_163718 V1269863 VICK T Histidine kinase 0XQQ4 Cluster_112061 V1269865 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_554976 V1269866 S NA 0YHD6 Cluster_30588 V1269867 PFLB map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_264383 V1269868 PFLA O Pyruvate formate-lyase COG1180 Cluster_52831 V1269871 MUTL map03430 L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) COG0323 Cluster_156120 V1269872 AROA map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate synthase COG0128 Cluster_152068 V1269874 map00400,map01100,map01110,map01230 E shikimate COG0703 Cluster_186505 V1269875 YACL S PilT protein domain protein COG4956 Cluster_603464 V1269877 RPLS map03010 J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) COG0335 Cluster_183833 V1269878 S lipolytic protein G-D-S-L family 11J8W Cluster_223173 V1269879 MT3796 S integral membrane protein COG1300 Cluster_14745 V1269880 PQQL O Peptidase, M16 COG0612 Cluster_148106 V1269881 S Lipoprotein 0YP1K Cluster_88132 V1269882 S NA 11V4N Cluster_16272 V1269883 P tonB-dependent Receptor 0XNUH Cluster_223174 V1269884 G Acyl-transferase COG3594 Cluster_14021 V1269885 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_182104 V1269886 YCHF J gtp-binding protein COG0012 Cluster_251564 V1269887 DEOC map00030 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) COG0274 Cluster_504866 V1269888 FRDB map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120 C succinate dehydrogenase fumarate reductase iron-sulfur subunit COG0479 Cluster_5440 V1269889 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_579774 V1269890 RPLL map03010 J Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) COG0222 Cluster_355455 V1269891 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_9529 V1269892 M Peptidase family S41 COG0793 Cluster_48770 V1269893 E peptidase, M24 COG0006 Cluster_218500 V1269894 MDH map00020,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120 C Malate dehydrogenase COG0039 Cluster_71834 V1269895 M Membrane 0XT9Z Cluster_90436 V1269896 GLDK O Sulphatase-modifying factor protein COG1262 Cluster_777568 V1269897 S Protein of unknown function (DUF2795) 11U61 Cluster_414441 V1269898 S O-methyltransferase-like protein 106VG Cluster_614460 V1269900 map02010 K Transcriptional regulator 10Z7N Cluster_263000 V1269901 S Inherit from COG: Aminoglycoside phosphotransferase COG3173 Cluster_65702 V1269902 PTSI map00051,map01100,map02060 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) COG1080 Cluster_394838 V1269903 S general stress protein 0XVE3 Cluster_138260 V1269904 S NA 0ZCNR Cluster_54543 V1269905 S Domain of unknown function DUF87 COG0433 Cluster_233737 V1269906 S NurA domain protein 11IQE Cluster_385962 V1269907 RPLY map03010 J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) COG1825 Cluster_70245 V1269908 CTP M Peptidase, S41 family COG0793 Cluster_427202 V1269909 COMEB map00240,map01100 F deaminase COG2131 Cluster_37648 V1269910 DCP E oligopeptidase A COG0339 Cluster_821011 V1269911 S NA 0XUY7 Cluster_13966 V1269912 PQQL O Peptidase, M16 COG0612 Cluster_122174 V1269913 map02010 V ABC-2 type transporter COG0842 Cluster_148845 V1269914 map02010 V ABC-2 type transporter COG0842 Cluster_222000 V1269915 M Auxiliary transport protein, membrane fusion protein COG0845 Cluster_90921 V1269916 M Outer membrane efflux protein COG1538 Cluster_3875 V1269917 CZCA P heavy metal efflux pump, czca family COG3696 Cluster_203996 V1269919 S NA 11QZ9 Cluster_167705 V1269920 map00051,map00363,map00591,map00625,map00650,map01100,map01120 C alcohol dehydrogenase COG1979 Cluster_219650 V1269921 K cell envelope-related transcriptional attenuator COG1316 Cluster_137495 V1269922 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_443061 V1269923 C Rubrerythrin COG1592 Cluster_402 V1269925 S NA 101UU Cluster_1495 V1269927 S NA 0YG6V Cluster_118414 V1269928 RFBX M Polysaccharide Biosynthesis Protein COG2244 Cluster_12421 V1269929 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_37649 V1269930 C Anaerobic dehydrogenase COG0243 Cluster_131141 V1269931 HOM E saf domain-containing protein COG4091 Cluster_93305 V1269932 ASPA map00250,map00910,map01100 E Aspartate ammonia-lyase COG1027 Cluster_394839 V1269933 RNHB map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0164 Cluster_621851 V1269934 L UPF0102 protein COG0792 Cluster_42420 V1269935 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_285977 V1269936 ISPE map00900,map01100,map01110 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COG1947 Cluster_108200 V1269937 APEA map00480,map01100 E M18 family aminopeptidase COG1362 Cluster_51927 V1269938 S PQQ enzyme repeat protein COG1520 Cluster_49591 V1269939 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_217362 V1269941 V Abi-like protein COG4823 Cluster_65402 V1269942 YJJK S ATP-binding cassette protein, ChvD family COG0488 Cluster_212726 V1269943 ASD map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) COG0136 Cluster_86389 V1269944 RLUB J Pseudouridine synthase COG1187 Cluster_118415 V1269945 PURB map00230,map00250,map01100,map01110 F adenylosuccinate lyase COG0015 Cluster_264384 V1269946 RFBD map00521,map00523,map01100,map01110 M Dtdp-4-dehydrorhamnose reductase COG1091 Cluster_75473 V1269947 PRFC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) COG4108 Cluster_352129 V1269948 TRPF map00400,map01100,map01110,map01230 E N-(5'-phosphoribosyl)anthranilate isomerase COG0135 Cluster_378913 V1269949 RPE map00030,map00040,map00710,map01100,map01110,map01120,map01230 G ribulose-phosphate 3-epimerase COG0036 Cluster_410756 V1269950 RPOE K RNA Polymerase 0XT41 Cluster_239910 V1269951 I Lipid kinase, YegS Rv2252 BmrU family COG1597 Cluster_238646 V1269952 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_78118 V1269953 S Phosphotransferase enzyme family COG3178 Cluster_721733 V1269955 GROS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) COG0234 Cluster_54544 V1269956 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_17070 V1269957 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_158705 V1269958 HLY map00270,map00450,map00920,map01100,map01110,map01230 E Aminotransferase class I and II COG1168 Cluster_103443 V1269961 S Replication initiator protein 0XR3Z Cluster_98445 V1269962 PIPD E Dipeptidase COG4690 Cluster_427203 V1269963 AHPC O alkyl hydroperoxide reductase COG0450 Cluster_11635 V1269964 S DNA repair protein 0XQPN Cluster_38319 V1269965 TOPB L Dna topoisomerase COG0550 Cluster_326084 V1269966 S NA 0ZBKA Cluster_74497 V1269967 M nlpC P60 family protein COG0791 Cluster_241193 V1269968 ETFA map00910 C Electron transfer flavoprotein COG2025 Cluster_61817 V1269969 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_118416 V1269970 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120 G phosphohexose isomerase COG0166 Cluster_164509 V1269971 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_252785 V1269972 S YitT family COG1284 Cluster_21855 V1269973 S NA 0XSI9 Cluster_49166 V1269974 MT2802 S atpase involved in dna repair 0XNTH Cluster_160407 V1269975 map00010,map00051,map00071,map00260,map00350,map00363,map00591,map00625,map00626,map00650,map00830,map00980,map00982,map01100,map01110,map01120 C alcohol dehydrogenase COG1454 Cluster_67155 V1269977 PHOR map02020 T Histidine kinase 0XNMH Cluster_47701 V1269978 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_42601 V1269979 YYBT T domain protein COG3887 Cluster_512620 V1269980 RPLI map03010 J Binds to the 23S rRNA (By similarity) COG0359 Cluster_117014 V1269981 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_264385 V1269982 K Inherit from NOG: Transcriptional regulator 1280Y Cluster_573440 V1269983 S NA 0YJPR Cluster_398356 V1269984 S Hydrolase COG1011 Cluster_143481 V1269985 DLTB map05150 M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_137496 V1269986 DLTD map05150 M D-alanyl-lipoteichoic acid biosynthesis protein DltD COG3966 Cluster_290024 V1269987 COF S Hydrolase COG0561 Cluster_482799 V1269988 YEAN G Major Facilitator Superfamily COG2807 Cluster_118417 V1269989 S Replication initiator protein 0XR3Z Cluster_708620 V1269991 K HTH_XRE 0XVMH Cluster_607084 V1269992 CKL_1914 K DNA-binding helix-turn-helix protein 0XUC3 Cluster_271091 V1269996 S NA 11KGV Cluster_294069 V1269997 BL00982 T head morphogenesis protein, SPP1 gp7 COG5585 Cluster_557896 V1269998 S Toxin-antitoxin system, antitoxin component, HicB family 12518 Cluster_57027 V1269999 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_121409 V1270000 MNTH P H( )-stimulated, divalent metal cation uptake system (By similarity) COG1914 Cluster_102275 V1270001 map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) COG1156 Cluster_45005 V1270002 NTPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_280418 V1270003 SP_1674 K transcriptional regulator COG1737 Cluster_263001 V1270004 GLCK map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G, K ROK family COG1940 Cluster_380634 V1270005 S integral membrane protein COG5578 Cluster_18048 V1270006 ADHE map00010,map00051,map00071,map00350,map00362,map00363,map00591,map00620,map00621,map00622,map00625,map00626,map00650,map01100,map01110,map01120 C Dehydrogenase COG1454 Cluster_114902 V1270007 BL03948 S nucleoside recognition domain protein COG3314 Cluster_123471 V1270009 S NA 0XPEA Cluster_139799 V1270010 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_567125 V1270011 RPSH map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) COG0096 Cluster_531831 V1270012 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_151235 V1270013 S Virulence-associated protein e COG5545 Cluster_39951 V1270014 PEPO O Endothelin-converting enzyme 1 COG3590 Cluster_285978 V1270015 V ABC, transporter COG1131 Cluster_358814 V1270016 MIP O Peptidyl-prolyl cis-trans isomerase COG0545 Cluster_74498 V1270017 S (LipO)protein 0Z3DA Cluster_220845 V1270019 L DNA uptake protein and related DNA-binding COG1555 Cluster_469446 V1270021 S NA 0XWCR Cluster_473704 V1270022 K RNA Polymerase COG1595 Cluster_26470 V1270023 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG1754 Cluster_844362 V1270024 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_115579 V1270026 LPDA map00010,map00020,map00260,map00280,map00620,map01100,map01110,map01120 C Dihydrolipoyl dehydrogenase COG1249 Cluster_92828 V1270027 GCVPB map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG1003 Cluster_427204 V1270028 XPT map00230,map01100,map01110 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) COG0503 Cluster_119148 V1270029 YICE F permease COG2233 Cluster_9229 V1270030 MEXF V AcrB AcrD family multidrug resistance protein COG0841 Cluster_142787 V1270031 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_215029 V1270032 YBHK S UPF0052 protein COG0391 Cluster_312298 V1270033 MACB2 V ABC transporter COG1136 Cluster_387771 V1270034 I PAP2 Family COG0671 Cluster_502459 V1270035 S Yqey-like protein COG1610 Cluster_785469 V1270036 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_365372 V1270037 LOLD V abc transporter atp-binding protein COG1136 Cluster_471609 V1270038 S (Lipo)protein COG4939 Cluster_492256 V1270039 V ABC transporter, permease COG0577 Cluster_135898 V1270040 Y2366 V ABC transporter, permease COG0577 Cluster_344182 V1270041 P19 P Periplasmic Protein COG3470 Cluster_78415 V1270042 PHNE_2 map02010 P phosphonate abc transporter COG3639 Cluster_57518 V1270043 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_269785 V1270044 METQ map02010 P (LipO)protein COG1464 Cluster_377131 V1270045 METI map02010 P ABC transporter, permease COG2011 Cluster_540303 V1270047 map00260,map00630,map00680,map01100,map01110,map01120,map01230 C Dehydrogenase COG1052 Cluster_32311 V1270048 HPPA map00190 C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for COG3808 Cluster_9157 V1270049 S Membrane 0XQTX Cluster_209424 V1270050 QUEG C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) COG1600 Cluster_34912 V1270051 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_817135 V1270052 V Efflux ABC transporter, permease protein 0XPE8 Cluster_661620 V1270053 ACIN_0074 L Transposase COG3464 Cluster_22801 V1270054 URAA F permease COG2233 Cluster_192619 V1270055 CKL_1835 S baseplate J family protein COG3299 Cluster_507441 V1270056 S Protein of unknown function (DUF2634) 11VAZ Cluster_51928 V1270059 LGAS_0607 T head morphogenesis protein, SPP1 gp7 COG5585 Cluster_298227 V1270061 K anti-repressor COG3645 Cluster_237322 V1270063 COMGB U Competence protein COG1459 Cluster_589497 V1270064 S DNA- binding protein COG4699 Cluster_453033 V1270065 S Membrane COG4129 Cluster_189911 V1270066 TRMI J tRNA (Adenine-N1-)-methyltransferase COG2519 Cluster_61818 V1270067 O m6 family metalloprotease domain protein COG4412 Cluster_206161 V1270068 MENF map00130,map01053,map01100,map01110 H Isochorismate synthase COG1169 Cluster_38679 V1270070 PPK1 map00190,map03018 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) COG0855 Cluster_57519 V1270071 U TraG family COG3505 Cluster_342578 V1270072 S Uncharacterized protein conserved in bacteria (DUF2064) COG3222 Cluster_22873 V1270073 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_9530 V1270074 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_50169 V1270075 ARGS map00970 J arginyL-tRNA synthetase COG0018 Cluster_42780 V1270077 HUTU map00340,map01100 E Urocanate hydratase COG2987 Cluster_64851 V1270078 FTCD map00340,map00670,map01100 E Glutamate formiminotransferase COG3643 Cluster_291343 V1270079 S Zinc ribbon domain protein 0YJTX Cluster_645112 V1270081 V HNH endonuclease COG1403 Cluster_66582 V1270082 S Terminase large subunit COG4626 Cluster_26782 V1270088 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_182105 V1270089 S Uncharacterised protein family (UPF0104) 10F01 Cluster_5908 V1270090 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_2534 V1270091 S Inherit from NOG: domain protein 0XQ9I Cluster_159561 V1270092 RARA L recombination factor protein RarA COG2256 Cluster_212727 V1270093 GAP map00010,map01100,map01110,map01120,map01230,map04066,map05010 G glyceraldehyde-3-phosphate dehydrogenase COG0057 Cluster_159562 V1270094 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_85124 V1270095 GPMI map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0696 Cluster_294070 V1270097 map00362,map01100,map01120 C Hydrolase COG0596 Cluster_90437 V1270098 map00300,map00550,map01100 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) COG0770 Cluster_167706 V1270099 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_36878 V1270100 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_32998 V1270101 UVRD map03420,map03430 L ATP-dependent DNA helicase pcra COG0210 Cluster_44843 V1270102 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_100574 V1270103 GATA map00970,map01100 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) COG0154 Cluster_475878 V1270104 CAS4 L crispr-associated protein Cas4 COG1468 Cluster_339607 V1270105 CAS6 L CRISPR-associated protein cas6 11MM9 Cluster_465239 V1270106 S Protein of unknown function (DUF523) COG5418 Cluster_592895 V1270108 ASPC map00250,map00270,map00290,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aminotransferase COG0436 Cluster_543231 V1270109 P Ferric uptake 11J37 Cluster_300888 V1270110 PHNP map00440 S Beta-lactamase domain protein COG1235 Cluster_213836 V1270111 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_76102 V1270113 C Thiol oxidoreductase COG3488 Cluster_159563 V1270114 S iron-regulated protein a 11RU6 Cluster_5688 V1270116 S NA 11QZ9 Cluster_267028 V1270117 M polysaccharide biosynthesis protein COG1086 Cluster_34204 V1270118 S NA 0Y35K Cluster_233739 V1270119 PSTS map02010,map02020,map05152 P phosphate COG0226 Cluster_70901 V1270121 TNAA map00350,map00380 E tryptophanase EC 4.1.99.1 COG3033 Cluster_133498 V1270122 S UPF0597 protein COG3681 Cluster_4314 V1270123 L DNA helicase COG1112 Cluster_99502 V1270124 MALQ map00500,map01100 G 4-alpha-glucanotransferase (EC 2.4.1.25) COG1640 Cluster_57520 V1270125 map02010 E ABC, transporter COG4166 Cluster_208389 V1270126 OPPF map02010 E (ABC) transporter COG4608 Cluster_114232 V1270127 PARB K parb-like partition protein COG1475 Cluster_621853 V1270128 S abc transporter atp-binding protein 11J2E Cluster_281747 V1270129 S VWA 1DKAP@verNOG Cluster_203997 V1270130 K, L, T serine threonine protein kinase COG0515 Cluster_844363 V1270131 S NA 0Z598 Cluster_239911 V1270132 SAGG map02010 V ABC transporter, ATP-binding protein COG1131 Cluster_32082 V1270133 V Type III restriction enzyme, res subunit 0ZVEA Cluster_185587 V1270134 L Type III restriction-modification system methylase COG2189 Cluster_469447 V1270137 RPSE map03010 J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) COG0098 Cluster_394840 V1270138 RPLD map03010 J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) COG0088 Cluster_199915 V1270139 RIBD map00740,map01100 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) COG0117 Cluster_705547 V1270140 S helix-turn-helix domain protein 122WR Cluster_49167 V1270141 FOKIM map03430 L Adenine-specific COG3392 Cluster_49 V1270143 M domain protein COG4932 Cluster_55998 V1270144 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG2812 Cluster_97896 V1270145 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_205075 V1270148 DNAG map03030 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 Cluster_573441 V1270158 S domain protein 0XNZW Cluster_60665 V1270159 YADE G polysaccharide deacetylase COG0726 Cluster_92373 V1270160 map01053 Q amino acid adenylation COG1020 Cluster_189912 V1270161 FEOB P Ferrous iron transport protein B COG0370 Cluster_57279 V1270162 V abc transporter permease protein 0XQE2 Cluster_309333 V1270163 ASPB map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aminotransferase COG0436 Cluster_117015 V1270164 NHAC-1 map00680 C Na H antiporter COG1757 Cluster_63470 V1270165 DPEP_1224 C Ferredoxin COG3894 Cluster_192620 V1270166 map00860,map01100,map01110 H Uroporphyrinogen decarboxylase COG0407 Cluster_32312 V1270168 S Protein of unknown function (DUF3160) 0XRJH Cluster_385963 V1270169 S NA 0XX04 Cluster_453034 V1270170 S ybak prolyl-trna synthetase COG3760 Cluster_109446 V1270171 SP_0562 P hemerythrin hhe cation binding domain protein COG2461 Cluster_355456 V1270172 RV1290C S Membrane COG4325 Cluster_206162 V1270173 POTD map02010 E ABC transporter COG0687 Cluster_285979 V1270174 UPPP map00550 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) COG1968 Cluster_33392 V1270175 UVRD map03420,map03430 L ATP-dependent DNA helicase pcra COG0210 Cluster_43141 V1270176 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_534624 V1270177 P Ferric uptake regulator, Fur family COG0735 Cluster_156975 V1270178 SPSC map00362,map00363,map00520,map00626,map00650,map00903,map01100,map01110,map01120,map02020 M Polysaccharide biosynthesis protein COG0399 Cluster_52596 V1270182 ACDA2 map00780,map01100 C CoA binding domain protein COG1042 Cluster_373644 V1270183 AAT O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) COG2360 Cluster_101158 V1270184 GLMM map00051,map00520,map01100,map01110 G phosphomannomutase COG1109 Cluster_44292 V1270185 CYSG map00860,map01100,map01110 H Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) COG1587 Cluster_157841 V1270187 COBW S CobW P47K family protein COG0523 Cluster_482800 V1270188 FTN map00860 P ferritin COG1528 Cluster_408908 V1270189 S Nitroreductase COG3560 Cluster_23578 V1270190 M Outer membrane protein, OMP85 family 0XNPU Cluster_365373 V1270191 TRMD map00900,map01100,map01110 J Specifically methylates guanosine-37 in various tRNAs (By similarity) COG0336 Cluster_451106 V1270192 S Protein of unknown function (DUF805) COG3152 Cluster_275110 V1270193 RSSA I Phospholipase, patatin family COG4667 Cluster_318482 V1270194 I Acyl-ACP thioesterase COG3884 Cluster_180357 V1270195 FOPA M ompA family 10ZT3 Cluster_445053 V1270196 PORG map00020,map00720,map01100,map01120 C oxidoreductase COG1014 Cluster_316896 V1270197 VORA map00020,map00280,map00720,map01100,map01120 C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein COG1013 Cluster_185588 V1270198 VORB map00020,map00280,map00720,map01100,map01120 C 2-oxoglutarate oxidoreductase, alpha subunit COG0674 Cluster_263002 V1270199 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_338184 V1270200 NADE map00760,map01100 H nh(3)-dependent nad( ) synthetase COG0171 Cluster_412575 V1270201 YEDK S Conserved protein COG2135 Cluster_73867 V1270202 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_287375 V1270203 FOLP map00790,map01100 H dihydropteroate synthase COG0294 Cluster_292686 V1270204 FOLK map00790,map01100 H 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase COG1539 Cluster_443062 V1270205 S hemerythrin hhe cation binding domain protein COG3945 Cluster_216169 V1270206 CPOA M Glycosyl transferase COG0438 Cluster_211636 V1270207 ASNA map00250,map00460,map00910,map01100,map01110,map01230 E asparagine synthetase A COG2502 Cluster_113516 V1270208 S RelA SpoT domain protein 0XPFE Cluster_134293 V1270209 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_241194 V1270210 SP_2113 S membrAne COG1284 Cluster_295480 V1270211 MALA S maltodextrose utilization protein MalA COG5521 Cluster_139015 V1270212 MALX map02010 G extracellular solute-binding protein family 1 COG2182 Cluster_85548 V1270213 MALQ map00500,map01100 G 4-alpha-glucanotransferase (EC 2.4.1.25) COG1640 Cluster_30122 V1270214 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG1640 Cluster_62635 V1270216 YABE M domain protein COG3584 Cluster_46733 V1270217 YDCP map05120 O Peptidase, U32 family COG0826 Cluster_23579 V1270218 P tonB-dependent Receptor COG4206 Cluster_143482 V1270219 S (LipO)protein 11H2K Cluster_44102 V1270221 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_91395 V1270222 ALGC map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G phosphomannomutase COG1109 Cluster_178655 V1270223 map02010 P Periplasmic binding protein 0XRC7 Cluster_211637 V1270224 map02010 P Iron chelate uptake ABC transporter, FeCT family, permease protein COG0609 Cluster_233740 V1270226 PRSA O Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) COG0760 Cluster_287376 V1270227 M (sortase) family COG3764 Cluster_272426 V1270228 SRTC M (sortase) family COG3764 Cluster_34913 V1270230 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_515337 V1270231 DTD J Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) COG1490 Cluster_139016 V1270232 HEMZ map00860,map01100,map01110 H coproporphyrinogen III oxidase COG0635 Cluster_212728 V1270233 GPSA map00564 C NADPH-dependent glycerol-3-phosphate dehydrogenase COG0240 Cluster_357160 V1270234 YLME F alanine racemase domain protein COG0325 Cluster_518005 V1270235 SEPF S Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) COG1799 Cluster_313796 V1270236 YLMH J s4 domain protein COG2302 Cluster_499917 V1270237 LSPA map03060 M, U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) COG0597 Cluster_11435 V1270238 T transcriptional activator COG3899 Cluster_259093 V1270239 E, G Membrane COG0697 Cluster_275111 V1270240 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_175363 V1270241 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_614461 V1270242 YLXM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) COG2739 Cluster_119910 V1270243 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_335106 V1270244 TRMD map00900,map01100,map01110 J Specifically methylates guanosine-37 in various tRNAs (By similarity) COG0336 Cluster_188200 V1270245 DPRA L DNA protecting protein DprA COG0758 Cluster_449125 V1270246 K regulatoR 11SNX Cluster_773878 V1270247 SP_0055 S NA 0XVC1 Cluster_138262 V1270248 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_44293 V1270249 S GBS Bsp-like repeat protein COG3942 Cluster_77139 V1270250 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_7401 V1270251 PURL F phosphoribosylformylglycinamidine synthase COG0047 Cluster_136707 V1270252 G Major Facilitator 0XPHU Cluster_526229 V1270253 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_53056 V1270254 M peptidase M23 0XQC5 Cluster_58803 V1270255 S Conserved Protein COG4866 Cluster_95218 V1270256 GLDK O Sulphatase-modifying factor protein COG1262 Cluster_43142 V1270257 S NA 11YT1 Cluster_284527 V1270258 T FHA 0YZ1Q Cluster_271092 V1270262 FBA map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01230 G Fructose-1,6-bisphosphate aldolase, class II COG0191 Cluster_27276 V1270264 M Ser Thr phosphatase family protein COG2247 Cluster_37496 V1270265 S NA 0ZJP4 Cluster_228957 V1270266 YUEF P permease COG0628 Cluster_119911 V1270267 HLYX P CBS domain protein COG1253 Cluster_329131 V1270268 TRER K GntR family transcriptional regulator COG2188 Cluster_38680 V1270269 TREB map00010,map00500,map00520,map02060 G pts system COG2190 Cluster_72491 V1270270 TREC map00052,map00500,map01100 G trehalose-6-phosphate hydrolase (EC 3.2.1.93) COG0366 Cluster_31972 V1270271 F Endonuclease Exonuclease phosphatase COG2374 Cluster_465240 V1270272 SP_1533 S Orthopoxvirus protein of unknown function (DUF830) 0YP8N Cluster_83807 V1270273 S GH3 auxin-responsive promoter 0ZVFE Cluster_198919 V1270274 RNC map03008,map05205 K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) COG0571 Cluster_96831 V1270276 map00450,map00970 J methionyL-tRNA synthetase COG0143 Cluster_269786 V1270277 YBBP S TIGR00159 family COG1624 Cluster_368690 V1270278 T Regulator COG0745 Cluster_112777 V1270279 S NA 11G8Y Cluster_377132 V1270281 COMEA L Competence protein COG1555 Cluster_39152 V1270282 FUSA2 J Translation elongation factor COG0480 Cluster_269787 V1270285 S Nucleotidyl transferase of unknown function (DUF1814) 0XP6B Cluster_167 V1270286 M domain protein COG4932 Cluster_649212 V1270290 L Transposase COG0675 Cluster_226658 V1270291 BATA S von Willebrand factor, type A COG2304 Cluster_193510 V1270292 S NA 0XQVA Cluster_268440 V1270293 S von Willebrand factor COG1721 Cluster_217363 V1270294 MOXR S ATPase family associated with various cellular activities (AAA) COG0714 Cluster_122848 V1270295 S DNA-binding protein hu 11T81 Cluster_232478 V1270296 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_859878 V1270297 S NA 0XZN2 Cluster_273755 V1270298 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_489764 V1270299 SMPB O Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) COG0691 Cluster_65703 V1270300 map00860,map01100,map01110 C radical SAM domain protein COG1032 Cluster_26262 V1270301 MUTS2 map03430 L muts2 protein COG1193 Cluster_38320 V1270302 PROTEASE map05120 O peptidase, U32 COG0826 Cluster_26034 V1270304 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_207257 V1270305 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_126816 V1270306 KTRB P Potassium uptake protein COG0168 Cluster_85125 V1270307 S NA 0YKBK Cluster_633185 V1270308 UVRD map03420,map03430 L DNA helicase COG0210 Cluster_456991 V1270309 map00051,map00363,map00591,map00625,map00650,map01100,map01120 S Nadph-dependent fmn reductase COG0431 Cluster_24695 V1270312 V Efflux ABC transporter, permease protein 0XPE8 Cluster_79798 V1270313 L Recombinase COG1961 Cluster_546160 V1270314 S recombinase 11R6K Cluster_80170 V1270315 L Site-specific recombinase COG1961 Cluster_793256 V1270316 S NA 0YWR8 Cluster_621 V1270317 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_96308 V1270318 ARCD S c4-dicarboxylate anaerobic carrier COG1288 Cluster_306601 V1270319 S Hydrolase COG0561 Cluster_461048 V1270322 YACP J Tetracycline resistance protein COG3688 Cluster_687971 V1270323 S NA 0ZMX8 Cluster_105203 V1270324 PHOR map02020 T Histidine kinase 0XNMH Cluster_30589 V1270325 S phosphate 0XP49 Cluster_271093 V1270326 OCAR_7318 map02030,map02040 N Ompa motb domain protein COG1360 Cluster_53786 V1270327 S Protein of unknown function (DUF1524) COG1479 Cluster_74824 V1270328 S ABC transporter, ATP-binding protein-related protein 11JYN Cluster_95717 V1270329 S fad dependent oxidoreductase COG2509 Cluster_115580 V1270330 HLYX P Domain of unknown function DUF21 COG1253 Cluster_418021 V1270331 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_150470 V1270332 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_330542 V1270333 K Transcriptional regulator COG1414 Cluster_34035 V1270334 G domain protein 11V8D Cluster_423457 V1270335 S Nitroreductase COG3560 Cluster_223175 V1270337 S NA 0YAQ6 Cluster_180358 V1270338 PDXA map00750,map01100 H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) COG1995 Cluster_327646 V1270339 DPM1 map00510,map01100 M dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) 0XQRC Cluster_181174 V1270341 PEPA map00500,map01100 E Peptidase m42 family protein COG1363 Cluster_51529 V1270342 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_128203 V1270343 RSEP map04112 M Membrane-associated zinc metalloprotease COG0750 Cluster_183834 V1270344 ULAG map00053,map01100,map01120 S L-ascorbate 6-phosphate lactonase COG2220 Cluster_117016 V1270345 NQRA C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) COG1726 Cluster_136708 V1270346 NQRF C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) COG2871 Cluster_79799 V1270347 PCCB map00280,map00630,map00640,map00720,map01100,map01120 I carboxyl transferase domain protein COG4799 Cluster_263003 V1270348 map00500,map01100,map01110 G synthase COG0297 Cluster_99503 V1270349 S (LipO)protein 11J26 Cluster_222001 V1270350 PABB map00790 E, H Para-aminobenzoate synthase, component I COG0147 Cluster_350624 V1270351 S Periplasmic Protein COG2859 Cluster_10725 V1270352 S peptidase C10 11SDT Cluster_198920 V1270353 FLGJ map00511 N, U flagellar rod assembly protein muramidase flgj COG1705 Cluster_112778 V1270355 HIPO map00360 E amidohydrolase COG1473 Cluster_225538 V1270356 ATPG map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) COG0224 Cluster_77824 V1270357 ATPA map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_751738 V1270358 ATPE map00190,map00195,map01100 C atp synthase 0ZXP1 Cluster_755206 V1270359 ATPC map00190,map00195,map01100 C ATP synthase, Delta Epsilon 11YZG Cluster_85126 V1270360 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_224367 V1270361 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 C Phosphofructokinase COG0205 Cluster_218501 V1270362 M glycosyltransferase group 2 family protein COG0463 Cluster_2025 V1270363 S NA 0YG6V Cluster_242566 V1270364 SITA map02010,map02020 P periplasmic solute binding protein COG0803 Cluster_370393 V1270365 SIRR K iron (metal) dependent repressor, dtxr family COG1321 Cluster_329132 V1270366 RSME S Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) COG1385 Cluster_171995 V1270367 L Integrase COG0582 Cluster_23425 V1270372 L Virulence-associated protein e COG5545 Cluster_285980 V1270373 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_394841 V1270374 RPLD map03010 J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) COG0088 Cluster_478069 V1270375 S NA 11WFA Cluster_18208 V1270376 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_309334 V1270377 S haloacid dehalogenase-like hydrolase COG0561 Cluster_813398 V1270378 S NA 124N5 Cluster_177813 V1270381 S NA 0XVB7 Cluster_520581 V1270382 S NA 0Z71H Cluster_168556 V1270383 MRP D ATP-binding protein COG0489 Cluster_12880 V1270384 S peptidase C10 11SDT Cluster_31973 V1270385 PTPA map04974 E peptidase COG1506 Cluster_137497 V1270386 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_353779 V1270387 LRGB map02020 M lrgb family COG1346 Cluster_607085 V1270388 LRGA map02020 S lrga family COG1380 Cluster_58804 V1270389 LMRA V ABC transporter COG1132 Cluster_61819 V1270390 MDLB map02010 V ABC transporter COG1132 Cluster_220846 V1270391 CKL_2970 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_134294 V1270392 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_105204 V1270393 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_299496 V1270394 ATPG map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) COG0224 Cluster_370394 V1270395 T cyclic nucleotide-binding domain protein COG0664 Cluster_319961 V1270396 SP_1381 V abc transporter atp-binding protein COG1131 Cluster_67899 V1270397 PGM map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase (EC 5.4.2.2 COG0033 Cluster_206163 V1270398 SELU S Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) COG2603 Cluster_296829 V1270399 DRAG O ADP-ribosylation crystallin J1 COG1397 Cluster_330543 V1270400 PPIB O PPIases accelerate the folding of proteins COG0652 Cluster_637240 V1270401 ILYOP_1738 S protein with conserved CXXC pairs COG3862 Cluster_177814 V1270402 S Copper amine oxidase domain protein 0ZW5W Cluster_223176 V1270403 DUSB J Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_312299 V1270404 COAX map00770,map01100 K Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) COG1521 Cluster_135086 V1270405 T Histidine kinase COG0642 Cluster_44294 V1270406 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_87275 V1270407 BL01323 M Cell wall binding repeat 2-containing protein 0ZKZU Cluster_324586 V1270408 PPID O Peptidyl-prolyl cis-trans isomerase COG0760 Cluster_275112 V1270409 YITL S S1 RNA binding domain protein COG2996 Cluster_298228 V1270410 ZURM map02010 P ABC, transporter COG1108 Cluster_370395 V1270411 ADCC map02010 P ABC transporter COG1121 Cluster_160408 V1270412 HOM map00260,map00270,map00300,map01100,map01110,map01120,map01230 E homoserine dehydrogenase COG0460 Cluster_28770 V1270413 THRC map00260,map00750,map01100,map01120,map01230 E Threonine synthase COG0498 Cluster_471610 V1270414 S Membrane Spanning Protein COG4720 Cluster_429088 V1270415 S NA 10391 Cluster_22103 V1270416 V Efflux ABC transporter, permease protein 0XPE8 Cluster_54759 V1270418 map02010 V ABC transporter 0XPIZ Cluster_11665 V1270419 SECD map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) COG0342 Cluster_49374 V1270421 S NA 102WG Cluster_327647 V1270422 SPOU J rrna methyltransferase COG0566 Cluster_47874 V1270423 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_678961 V1270424 RPLU map03010 J This protein binds to 23S rRNA in the presence of protein L20 (By similarity) COG0261 Cluster_699400 V1270425 YHBY J Rna-binding protein COG1534 Cluster_403654 V1270426 NADD map00230,map00760,map01100,map05340 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) COG1057 Cluster_265711 V1270427 LYTR K TRANSCRIPTIONal COG1316 Cluster_24571 V1270428 S NA 0Y23X Cluster_184714 V1270430 WBPI map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_725082 V1270431 PHOB map00627,map00790,map01100,map01120,map02020 P alkaline phosphatase COG1785 Cluster_418022 V1270432 Y1496 G Bacterial protein of unknown function (DUF925) COG3575 Cluster_193511 V1270433 DHAK map00561,map00680,map01100,map01120,map04622 G Dihydroxyacetone kinase COG2376 Cluster_67156 V1270434 S NA 101UU Cluster_28967 V1270435 MAEB map00620,map00710,map01100,map01120 C Malic enzyme COG0281 Cluster_108201 V1270436 S Periplasmic protein 11GM9 Cluster_80979 V1270437 ALGI M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_199916 V1270438 U ABC transport system, lipoprotein 0XPU6 Cluster_133499 V1270439 AMPG2 E, G, P Beta-lactamase induction signal transducer COG0477 Cluster_37022 V1270440 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_216170 V1270441 S Acyltransferase family 0YSHG Cluster_387772 V1270442 VNCS T Histidine kinase COG0642 Cluster_127512 V1270443 VEX3 V abc transporter permease protein COG0577 Cluster_382414 V1270444 VEX2 V abc transporter atp-binding protein COG1136 Cluster_135087 V1270445 VEX1 V ABC transporter, permease COG0577 Cluster_76103 V1270446 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_47702 V1270447 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_277746 V1270448 S NA 0XP5S Cluster_186506 V1270449 APBE H ApbE family COG1477 Cluster_32200 V1270451 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_338185 V1270452 MTAP map00270,map01100 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) COG0005 Cluster_263004 V1270453 YPJC S YitT family COG1284 Cluster_333595 V1270454 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_141288 V1270455 UMUC L Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) COG0389 Cluster_601 V1270456 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_99504 V1270457 T Histidine kinase 0XNMH Cluster_100575 V1270458 GATB map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 Cluster_96832 V1270459 GATA map00970,map01100 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) COG0154 Cluster_42602 V1270460 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_32571 V1270461 UVRD map03420,map03430 L ATP-dependent DNA helicase pcra COG0210 Cluster_362061 V1270462 YGDL H uba thif-type nad fad binding protein COG1179 Cluster_194443 V1270463 S domain protein 12C1H Cluster_31300 V1270464 L phage plasmid primase, p4 family COG3378 Cluster_130366 V1270465 S Domain of unknown function (DUF955) 0ZI1U Cluster_134295 V1270466 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2801 Cluster_398358 V1270467 S cytosolic protein 0XSPM Cluster_170354 V1270468 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_421609 V1270469 TAG map03410 L Dna-3-methyladenine glycosylase i COG2818 Cluster_523324 V1270470 ARGR K Regulates arginine biosynthesis genes (By similarity) COG1438 Cluster_373645 V1270471 GLUC map02010 E ABC transporter COG0765 Cluster_335107 V1270472 PABC map00280,map00290,map00310,map00330,map00360,map00472,map00473,map00770,map00790,map01100,map01110,map01210,map01230 E brancheD-chain amino acid aminotransferase COG0115 Cluster_156977 V1270473 S peptidase, S41 11U77 Cluster_447109 V1270474 K acetyltransferase, (GNAT) family COG0454 Cluster_355457 V1270475 YDFK S Membrane COG1811 Cluster_158706 V1270477 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_21688 V1270479 MPRF map05150 J Membrane COG2898 Cluster_127513 V1270480 map00362,map01100,map01120 S Alpha beta hydrolase COG0596 Cluster_213837 V1270481 L Dna topoisomerase COG0550 Cluster_578 V1270483 map05132 M repeat protein COG3209 Cluster_183006 V1270484 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_161228 V1270485 LGAS_0605 S phage terminase large subunit 0XSCY Cluster_59595 V1270486 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_9272 V1270487 S tonB-dependent receptor plug 0XNX2 Cluster_342579 V1270488 S Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) COG1385 Cluster_408909 V1270489 S Protein of unknown function (DUF3256) 11UJE Cluster_385964 V1270490 COMEA L Competence protein COG1555 Cluster_352130 V1270491 T Response Regulator COG0745 Cluster_497255 V1270492 LUXS map00270,map05111 T Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) COG1854 Cluster_182106 V1270493 MRDB M Rod shape-determining protein rodA COG0772 Cluster_393026 V1270494 NTH map03410 L endonuclease III COG0177 Cluster_534625 V1270495 PYRI map00240,map00250,map01100 F Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) COG1781 Cluster_156121 V1270496 PYRC map00230,map00240,map00410,map00770,map00983,map01100,map01120 F dihydroorotase COG0044 Cluster_263005 V1270497 PYRF map00240,map00983,map01100 F orotidine 5''-phosphate decarboxylase COG0284 Cluster_342580 V1270498 PYRK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) COG0543 Cluster_257762 V1270499 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate (By similarity) COG0167 Cluster_546161 V1270500 RPLM map03010 J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) COG0102 Cluster_56769 V1270501 PEPF map04614,map05143 E Oligoendopeptidase f COG1164 Cluster_8093 V1270502 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0587 Cluster_307915 V1270503 LGT M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 Cluster_213838 V1270505 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_203998 V1270506 PURM map00230,map01100,map01110 F phosphoribosylaminoimidazole synthetase COG0150 Cluster_362062 V1270507 PURC map00230,map01100,map01110 F Phosphoribosylaminoimidazolesuccinocarboxamide synthase COG0152 Cluster_34914 V1270508 PPK map00190,map03018 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) COG0855 Cluster_12713 V1270509 PITRM1 O peptidase COG1026 Cluster_540304 V1270512 MRAZ S Cell division protein mraZ COG2001 Cluster_30123 V1270513 FTSI map00550,map01100 M Stage V sporulation protein D COG0768 Cluster_225539 V1270514 MRAY map00550,map01100 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) COG0472 Cluster_504867 V1270515 NRDR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) COG1327 Cluster_147314 V1270516 FTSW D cell cycle protein COG0772 Cluster_111442 V1270517 S NA 11G8Y Cluster_357161 V1270518 T Two component transcriptional regulator, winged helix family COG0745 Cluster_12881 V1270519 RECB map03440 L UvrD REP helicase COG1074 Cluster_75173 V1270521 S membrane protein involved in aromatic hydrocarbon degradation 0YMT5 Cluster_37804 V1270523 GLGB map00500,map01100,map01110 G 1,4-alpha-glucan branching enzyme COG0296 Cluster_142788 V1270524 SP_2027 S MORN repeat protein COG4642 Cluster_77140 V1270525 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_162901 V1270526 BDHA map00051,map00363,map00591,map00625,map00650,map01100,map01120 C alcohol dehydrogenase COG1979 Cluster_721734 V1270527 LIVM map02010 E amino acid COG4177 Cluster_202946 V1270528 S NA 0XS0Q Cluster_363629 V1270529 K Transcriptional regulator 120E9 Cluster_401862 V1270530 S HAD-superfamily hydrolase subfamily IA variant 3 COG0637 Cluster_292687 V1270531 PANB map00770,map01100,map01110 H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) COG0413 Cluster_22701 V1270532 FEOB P Ferrous iron transport protein B COG0370 Cluster_31617 V1270533 PBP2A map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_88584 V1270534 map02010 P Zinc ABC superfamily ATP binding cassette transporter, binding protein COG3443 Cluster_298229 V1270535 ADCB map02010 P ABC, transporter COG1108 Cluster_265712 V1270537 MVK map00900,map01100,map01110,map04146 I mevalonate kinase COG1577 Cluster_209426 V1270538 FNI map00900,map01100,map01110 C Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) COG1304 Cluster_162067 V1270539 MVAS map00072,map00280,map00650,map00900,map01100,map01110 I Hydroxymethylglutaryl-CoA synthase COG3425 Cluster_312300 V1270540 YJJP S Membrane COG2966 Cluster_160409 V1270541 ARCA map00330,map01100,map01110 E Arginine dihydrolase COG2235 Cluster_471611 V1270542 WECD map00350,map00362,map00627,map00642,map00903,map01120 S -acetyltransferase 11PF0 Cluster_512622 V1270543 RIMI O ribosomal-protein-alanine acetyltransferase COG0456 Cluster_494746 V1270544 S NA 125SF Cluster_108202 V1270554 THIM map00730,map01100 H 4-methyl-5-beta-hydroxyethylthiazole kinase COG2145 Cluster_348992 V1270555 S tigr02206 127PX Cluster_407135 V1270556 K Transcriptional regulator, TetR family 11JD6 Cluster_309335 V1270557 BL05341 S NA 0ZJ54 Cluster_465241 V1270558 ENTB Q isochorismatase COG1335 Cluster_385965 V1270559 NADD map00230,map00760,map01100,map05340 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) COG1057 Cluster_670139 V1270560 YHBY J Rna-binding protein COG1534 Cluster_181175 V1270561 YQEH S ribosome biogenesis GTPase YqeH COG1161 Cluster_100026 V1270562 GATB map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 Cluster_94176 V1270563 GATA map00970,map01100 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) COG0154 Cluster_152904 V1270564 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_163719 V1270565 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_355458 V1270566 S Membrane COG1738 Cluster_281748 V1270567 O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG0526 Cluster_231302 V1270568 P K -dependent Na -Ca exchanger COG0530 Cluster_29449 V1270569 P Sodium/hydrogen exchanger family COG0475 Cluster_54304 V1270570 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG2812 Cluster_97368 V1270571 YHEH V ABC transporter COG1132 Cluster_257763 V1270573 PRMA J Methylates ribosomal protein L11 (By similarity) COG2264 Cluster_133500 V1270574 YQEV J MiaB-like tRNA modifying enzyme COG0621 Cluster_828768 V1270575 RPSU map03010 J 30S ribosomal protein S21 COG0828 Cluster_512623 V1270576 YQEY S gatB Yqey COG1610 Cluster_116307 V1270577 S Radical SAM superfamily COG0641 Cluster_135088 V1270578 SECD map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) COG0342 Cluster_14686 V1270579 map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_801203 V1270580 VRAR map02020 T response regulator COG2197 Cluster_352131 V1270581 S Cell wall-active antibiotics response protein (DUF2154) COG4758 Cluster_241196 V1270582 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_25212 V1270583 PRIA map03440 L Primosomal protein n' COG1198 Cluster_74499 V1270584 RNY S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 Cluster_128916 V1270586 map02020 T Histidine kinase 11JQW Cluster_144242 V1270589 S Protein of unknown function (DUF2812) 11ZMJ Cluster_507442 V1270590 SG1639 S Phage-Associated Protein COG3600 Cluster_394842 V1270591 S NA 0ZMX8 Cluster_187344 V1270594 V restriction 11FSE Cluster_271094 V1270595 MSRA S methionine sulfoxide reductase A 0YJ5R Cluster_101709 V1270597 J HAD-superfamily hydrolase subfamily IA variant 3 COG0637 Cluster_134296 V1270598 S modulator of DNA gyrase family protein COG0312 Cluster_41843 V1270599 YYBT T domain protein COG3887 Cluster_135089 V1270600 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_330544 V1270601 S Inherit from COG: Alpha beta hydrolase COG0596 Cluster_116308 V1270603 SP_0239 S UPF0210 protein COG2848 Cluster_389489 V1270604 S NA 0YN8E Cluster_543232 V1270605 BCOA_0505 L transposase COG0675 Cluster_665836 V1270608 S NA 0Y0U9 Cluster_391219 V1270609 V abc transporter permease protein 0ZW5X Cluster_48546 V1270610 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_110758 V1270611 MNME S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 Cluster_333596 V1270612 YIDC map03060,map03070 U Membrane COG0706 Cluster_637241 V1270613 RNPA J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) COG0594 Cluster_101710 V1270614 MVAA map00900,map01100,map01110,map04976 I hydroxymethylglutaryL-CoA reductase COG1257 Cluster_135899 V1270616 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_445054 V1270617 SEPF S Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) COG1799 Cluster_305221 V1270618 YLMH J s4 domain protein COG2302 Cluster_15106 V1270619 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_21856 V1270621 IRP P tonB-dependent Receptor COG1629 Cluster_303708 V1270622 ECFT map02010 P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) COG0619 Cluster_265713 V1270623 ECFA1 map02010 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates COG1122 Cluster_447110 V1270624 PGSA map00564,map01100 I cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase COG0558 Cluster_130367 V1270625 YMFH O peptidase, M16 COG0612 Cluster_142789 V1270626 SP_2225 O peptidase, M16 COG0612 Cluster_183835 V1270627 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_755207 V1270629 YABO J s4 domain protein COG1188 Cluster_687972 V1270630 HUP L DNA-binding protein COG0776 Cluster_401863 V1270631 COMEA L Competence protein COG1555 Cluster_344183 V1270632 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_855819 V1270633 FOKIM L Adenine-specific COG3392 Cluster_840328 V1270634 K Transcriptional regulator 0XUP9 Cluster_705548 V1270635 S domain protein 12A92 Cluster_131912 V1270636 ALGI M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_63756 V1270638 NIST map02010 V ABC transporter 0XPIZ Cluster_19378 V1270639 CLPB O ATP-dependent chaperone protein ClpB COG0542 Cluster_363630 V1270640 YAEB S Methyltransferase, YaeB family COG1720 Cluster_43143 V1270641 S Oligopeptide transporter, Opt family COG1297 Cluster_355459 V1270642 CMK map00240,map00410,map00770,map01100,map01110 F Cytidine monophosphate kinase COG0283 Cluster_766467 V1270643 RLUB J Pseudouridine synthase COG1187 Cluster_734921 V1270644 YIDD S Could be involved in insertion of integral membrane proteins into the membrane (By similarity) COG0759 Cluster_142790 V1270645 TRKA P potassium transporter peripheral membrane COG0569 Cluster_81353 V1270646 YJCE P Na H antiporter COG0025 Cluster_1611 V1270647 M Inherit from NOG: Polymorphic outer membrane protein 11KKP Cluster_156978 V1270648 NUSA K Transcription elongation factor NusA COG0195 Cluster_14515 V1270649 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_599865 V1270650 RBFA J Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) COG0858 Cluster_72492 V1270651 YJBB P Na Pi-cotransporter COG1283 Cluster_546162 V1270652 YJDF S Protein of unknown function (DUF2992) 11PXB Cluster_241197 V1270653 BIRA map00780,map01100 H biotin acetyl-CoA-carboxylase ligase COG0340 Cluster_215030 V1270654 GALR K Transcriptional regulator COG1609 Cluster_276438 V1270655 MSMR K Transcriptional regulator, ARAC family COG2207 Cluster_33879 V1270656 AGA map00052,map00561,map00600,map00603 G alpha-galactosidase COG3345 Cluster_271095 V1270657 MSMF map02010 P ABC transporter, permease COG1175 Cluster_97897 V1270658 GTFA map00500 G Sucrose phosphorylase COG0366 Cluster_360482 V1270659 KDTA map00340,map00350,map00540,map00624,map01100,map01120 M 3-Deoxy-D-manno-octulosonic-acid transferase COG1519 Cluster_86390 V1270660 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_57028 V1270661 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_405475 V1270662 SP_0622 C Nitroreductase COG0778 Cluster_98446 V1270663 PEPV map00300,map00480,map01100,map01120,map01230 E Dipeptidase COG0624 Cluster_84291 V1270664 map02010 E glycine betaine transport system COG1732 Cluster_699401 V1270665 S NA 1260K Cluster_471612 V1270666 J Threonine alanine tRNA ligase second additional domain protein COG0013 Cluster_66863 V1270667 AMYA2 map00500 G alpha amylase, catalytic 0XQRS Cluster_190765 V1270668 S NA 0ZWJK Cluster_82552 V1270669 RPRX map02020 T Histidine kinase COG5002 Cluster_34036 V1270670 FUSA2 T elongation factor G COG0480 Cluster_220847 V1270671 S cAMP factor 0YS1B Cluster_10770 V1270672 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_85127 V1270673 LIPL48 S (LipO)protein 0XQ4U Cluster_14817 V1270674 P tonB-dependent Receptor COG1629 Cluster_375355 V1270675 S NA 11YTD Cluster_360483 V1270676 S NA 0Y05K Cluster_128917 V1270677 COBB map00860,map01100 H Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) COG1797 Cluster_441067 V1270678 COBL map00860,map01100 H Precorrin-6y C5,15-methyltransferase COG2242 Cluster_13498 V1270679 AASI_0454 S NA 0XPYJ Cluster_573442 V1270680 S sigma-70, region 4 11JJM Cluster_610736 V1270681 L Integrase core domain protein COG2801 Cluster_451107 V1270682 BIOY map02010 S bioY protein COG1268 Cluster_78792 V1270683 U TraG family COG3505 Cluster_143483 V1270684 S (LipO)protein 11H2K Cluster_62385 V1270685 PGN_0950 V ABC transporter, ATP-binding protein COG1132 Cluster_57774 V1270686 LMRA V ABC transporter, ATP-binding protein COG1132 Cluster_284528 V1270687 S Calcineurin-like phosphoesterase COG1408 Cluster_729 V1270688 S NA 11NI8 Cluster_8683 V1270689 O ADP-ribosylglycohydrolase COG1397 Cluster_146531 V1270690 SUFS map00450,map00730,map01100 E Cysteine desulfurase COG0520 Cluster_510040 V1270691 NIFU C SUF system FeS assembly protein, NifU family COG0822 Cluster_142791 V1270692 DACA map00550,map01100 M carboxypeptidase COG1686 Cluster_329134 V1270693 GLNQ map02010 E ABC transporter, ATP-binding protein COG1126 Cluster_439068 V1270694 I PAP2 Family COG0671 Cluster_174554 V1270695 MSMK map02010 G ABC transporter, ATP-binding protein COG3839 Cluster_268442 V1270696 LRP Q, T Leucine-rich protein COG2508 Cluster_31848 V1270697 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_300890 V1270698 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_238647 V1270699 TRXB map00240,map00450 O Thioredoxin reductase COG0492 Cluster_178656 V1270700 MSRB O reductase COG0229 Cluster_267029 V1270701 UDP map00240,map00983,map01100 F Phosphorylase COG2820 Cluster_108203 V1270702 MNME S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 Cluster_657424 V1270703 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_8469 V1270704 map03440 L UvrD REP helicase COG1074 Cluster_13585 V1270705 AASI_0454 S NA 0XPYJ Cluster_30590 V1270707 DNAQ map03022,map03420 L helicase COG1199 Cluster_309336 V1270708 YKUD M ErfK ybiS ycfS ynhG family protein COG1376 Cluster_67157 V1270710 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_119149 V1270711 MUTL2 map00660,map01100 S glutamate mutase, mutL 0XRSI Cluster_150471 V1270712 T Histidine kinase COG0642 Cluster_350625 V1270713 T response regulator COG0745 Cluster_95718 V1270715 SCRB map00052,map00500,map01100 G sucrose-6-phosphate hydrolase COG1621 Cluster_504868 V1270716 YWTE S hydrolase COG0561 Cluster_89523 V1270717 AMIC map02010 P Permease protein COG0601 Cluster_267030 V1270718 NNRD G Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) COG0063 Cluster_131142 V1270719 VEX1 V ABC transporter, permease COG0577 Cluster_108817 V1270720 VEX3 V abc transporter permease protein COG0577 Cluster_113517 V1270721 ACCC map00061,map00253,map00620,map00640,map00720,map01100,map01110,map01120 I acetyl-CoA carboxylase biotin carboxylase COG0439 Cluster_9604 V1270722 L UvrD REP helicase COG1074 Cluster_45575 V1270723 PPPA map03070 T phosphatase COG0631 Cluster_520582 V1270724 S QueT transporter COG4708 Cluster_236127 V1270725 PANE map00770,map01100,map01110 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) COG1893 Cluster_45006 V1270726 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_231303 V1270727 DAGK I Diacylglycerol kinase COG1597 Cluster_26676 V1270728 PULA map00500,map01100,map04973 G pullulanase COG1523 Cluster_633186 V1270729 SZO_02100 L Transposase COG2801 Cluster_499918 V1270730 L Transposase COG2963 Cluster_467336 V1270731 YRXA K 3H domain protein COG1827 Cluster_456992 V1270732 SP_1233 S NA 11YD9 Cluster_197928 V1270734 BA_5704 S Acyl-transferase COG3274 Cluster_172910 V1270735 S ATP-NAD AcoX kinase COG3199 Cluster_139800 V1270736 PYRC map00240,map01100 F dihydroorotase COG0044 Cluster_401864 V1270737 S NA 0ZVIT Cluster_864177 V1270738 S Nucleotidyl transferase of unknown function (DUF1814) 0XP6B Cluster_715179 V1270739 YVBA K Transcriptional regulator, arsr family COG0640 Cluster_243912 V1270740 K Transcriptional regulator 11TH8 Cluster_494747 V1270741 G Tripartite ATP-independent periplasmic transporter dctq component COG3090 Cluster_302263 V1270742 OCAR_4090 map00240,map00380,map00410,map00460,map00627,map00643,map00770,map00910,map00983,map01100,map01120 S nitrilase cyanide hydratase and apolipoprotein n-acyltransferase COG0388 Cluster_234925 V1270743 UPPP map00550 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) COG1968 Cluster_132662 V1270744 SUN J ribosomal RNA small subunit methyltransferase b COG0144 Cluster_26783 V1270745 PRIA map03440 L Primosomal protein n' COG1198 Cluster_401865 V1270747 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG0194 Cluster_6733 V1270748 S NA 0YZ82 Cluster_63186 V1270749 DEAD map03018 L ATP-dependent RNA helicase COG0513 Cluster_144989 V1270750 map02010 S Permease, YjgP YjgQ family COG0795 Cluster_345797 V1270751 SMTA map00340,map00350,map00624,map01120 J Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) COG4123 Cluster_158707 V1270752 BIOF map00260,map00600,map00780,map01100 E 8-amino-7-oxononanoate synthase COG0156 Cluster_499919 V1270753 SP_1597 S Membrane COG4720 Cluster_313797 V1270754 THID map00750,map01100 H Phosphomethylpyrimidine kinase COG0351 Cluster_326085 V1270755 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_49375 V1270756 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_357162 V1270757 YJHF map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_250343 V1270758 RDRA K Transcriptional regulator COG1349 Cluster_230134 V1270759 SORC K regulatoR COG2390 Cluster_657425 V1270760 CELA map02060 G PTS System COG1440 Cluster_23789 V1270761 YBIW map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_368691 V1270762 G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) COG0176 Cluster_186507 V1270763 GLDA map00561,map01100 C glycerol dehydrogenase COG0371 Cluster_144990 V1270764 CLOSA_0730 V Hnh endonuclease COG1479 Cluster_610737 V1270765 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_706 V1270766 S Phage tail tape measure protein, TP901 family 125CR Cluster_256478 V1270767 GALU map00040,map00052,map00500,map00520,map01100,map01110 M UTP-glucose-1-phosphate uridylyltransferase COG1210 Cluster_210508 V1270768 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_66864 V1270769 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_28968 V1270772 TEX K domain protein COG2183 Cluster_44295 V1270773 S ABC transporter, ATP-binding protein COG0488 Cluster_321443 V1270775 SP_1071 S abc transporter atp-binding protein COG1101 Cluster_207259 V1270776 ATU2672 S ABC transporter COG2984 Cluster_70548 V1270777 FBPA K Fibronectin-binding protein COG1293 Cluster_341059 V1270778 BUDA map00650,map00660 Q Alpha-acetolactate decarboxylase COG3527 Cluster_142792 V1270779 SP_1504 S Tetratricopeptide repeat protein COG0457 Cluster_261709 V1270780 YUBA P permease COG0628 Cluster_132663 V1270781 S Conserved Protein COG4804 Cluster_121410 V1270782 L Site-specific recombinase, phage integrase family 11F8N Cluster_3901 V1270783 G Aamy_C COG1523 Cluster_119912 V1270784 map02010 P extracellular solute-binding protein COG1840 Cluster_131143 V1270785 PURA map00230,map00250,map01100 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis COG0104 Cluster_288740 V1270787 S ABC transporter COG1079 Cluster_554977 V1270789 RNHA map03030 S ribonuclease COG3341 Cluster_152069 V1270790 DEGT E DegT DnrJ EryC1 StrS aminotransferase COG0399 Cluster_507443 V1270791 ASP S alkaline shock protein COG1302 Cluster_312301 V1270793 MRAZ S Cell division protein mraZ COG2001 Cluster_492257 V1270794 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_323003 V1270795 NADE map00760,map01100 H nh(3)-dependent nad( ) synthetase COG0171 Cluster_200919 V1270797 S NA 0ZUR0 Cluster_80980 V1270798 map02010 V Abc transporter COG1131 Cluster_218502 V1270799 RNFD C Electron transport complex COG4658 Cluster_249089 V1270800 RNFB C electron transport complex, RnfABCDGE type, B subunit COG2878 Cluster_546163 V1270801 SPAT map02010 V ABC transporter 0XPIZ Cluster_269788 V1270802 V (ABC) transporter 0XQRE Cluster_150472 V1270804 S NA 123IR Cluster_465242 V1270805 G Domain-Containing protein 11Q0T Cluster_92829 V1270806 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_199917 V1270807 M polysaccharide deacetylase COG0726 Cluster_41386 V1270808 S S-layer domain protein 0XS72 Cluster_158708 V1270809 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_232479 V1270810 DAPF E Diaminopimelate epimerase COG0253 Cluster_183836 V1270811 S NA 17W8E@proNOG Cluster_45181 V1270812 L SNF2 family N-terminal domain COG0553 Cluster_132664 V1270813 S NA 11FM9 Cluster_119150 V1270815 map00270,map01100 L C-5 cytosine-specific DNA methylase COG0270 Cluster_41043 V1270817 NDHF map00190,map00910,map01100 C Proton-translocating NADH-quinone oxidoreductase, chain L COG1009 Cluster_21494 V1270818 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_109447 V1270819 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_24471 V1270820 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_16942 V1270821 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_1538 V1270822 GBS0386 S domain protein 0XRRR Cluster_27890 V1270823 GBS0384 S NA 0Y5Y1 Cluster_421610 V1270824 S Hydrolase COG0637 Cluster_7547 V1270825 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0587 Cluster_249090 V1270826 WHIA K May be required for sporulation (By similarity) COG1481 Cluster_223177 V1270827 HK01 T Histidine kinase COG0642 Cluster_43144 V1270828 map02020 V ABC transporter, permease COG0577 Cluster_583010 V1270829 SP_1023 map00350,map00362,map00627,map00642,map00903,map01120 K Acetyltransferase GNAT Family COG0454 Cluster_83808 V1270830 DPPA E Extracellular solute-binding protein, family 5 COG0747 Cluster_557897 V1270831 S NA 12ATY Cluster_557898 V1270833 S NA 0ZZ7Z Cluster_226659 V1270834 DNAC L DNA replication protein COG1484 Cluster_425264 V1270835 S Acetyltransferase GNAT Family 124QK Cluster_485126 V1270836 K Transcriptional regulator (AsnC family) COG1522 Cluster_316 V1270838 M domain protein COG4932 Cluster_141289 V1270840 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_159564 V1270841 S NA 124DC Cluster_224369 V1270842 Y2124 S Protein of unknown function (DUF1460) 0YV3U Cluster_133501 V1270844 TIG O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COG0544 Cluster_358815 V1270845 S B3_4 COG3382 Cluster_125423 V1270846 SUN map00340,map00350,map00624,map01120 J NOL1 NOP2 sun family protein COG0144 Cluster_303709 V1270847 THYA map00240,map00670,map01100 F Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) COG0207 Cluster_494748 V1270848 U Biopolymer transport protein exbD tolR 11GVS Cluster_193512 V1270849 DHAK map00561,map00680,map01100,map01120,map04622 G Dihydroxyacetone kinase COG2376 Cluster_355460 V1270850 GPMA1 map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0588 Cluster_405476 V1270851 RIBU S Membrane COG3601 Cluster_718426 V1270852 S addiction module toxin, RelE StbE family COG3041 Cluster_741652 V1270853 L dna damage-inducible protein 0ZX1H Cluster_196172 V1270854 S NA 0XWFB Cluster_463158 V1270855 ATPF map00190,map00195,map01100 C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) COG0711 Cluster_439069 V1270856 ATPH map00190,map00195,map01100 C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) COG0712 Cluster_88133 V1270857 ATPA map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_276439 V1270858 ATPG map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) COG0224 Cluster_104617 V1270859 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_59596 V1270860 E Oligoendopeptidase f COG1164 Cluster_441068 V1270861 S Protein of unknown function (DUF1700) 11XIW Cluster_817136 V1270863 S NA 0Y0C9 Cluster_108204 V1270864 S NA 11IN7 Cluster_549195 V1270865 PHAJ I MaoC domain protein dehydratase COG2030 Cluster_196173 V1270866 SUA J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0009 Cluster_540305 V1270869 ARSC T Protein-tyrosine phosphatase, low molecular weight COG0394 Cluster_217364 V1270870 PERMEASE S permease COG0701 Cluster_195319 V1270871 ARSB P arsenicaL-resistance protein COG0798 Cluster_670140 V1270872 ARSR K Transcriptional regulator, arsR family COG0640 Cluster_423458 V1270873 S NA 0Y3IW Cluster_728402 V1270874 YAZA L domain protein COG2827 Cluster_398359 V1270875 RECX S Modulates RecA activity (By similarity) COG2137 Cluster_607086 V1270876 T FHA domain 0XUTQ Cluster_138263 V1270877 FTSW D cell cycle protein COG0772 Cluster_98447 V1270878 FTSI map00550 M penicillin-binding protein COG0768 Cluster_102276 V1270879 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_456993 V1270880 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_267031 V1270881 NADC map00760,map01100 H nicotinate-nucleotide pyrophosphorylase COG0157 Cluster_78119 V1270882 NADB map00250,map00760,map01100 H L-aspartate oxidase COG0029 Cluster_58805 V1270883 map00190,map00680,map01100 C ATP synthase alpha/beta chain, C terminal domain COG1155 Cluster_218503 V1270884 NTPC map00190,map00680,map01100 C ATP synthase subunit C COG1527 Cluster_497256 V1270885 NTPK map00190,map00680,map01100 C V-type sodium ATPase, K subunit COG0636 Cluster_163720 V1270888 M phage lysin (EC 3.2.1.17) COG1388 Cluster_261710 V1270890 S n-acetylglucosamine 0ZDER Cluster_226660 V1270891 KDSD M Arabinose 5-phosphate isomerase COG0794 Cluster_124765 V1270892 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_380635 V1270893 K transcriptional regulator, luxR family COG2197 Cluster_233741 V1270894 K hemerythrin hhe cation binding domain protein 11HP7 Cluster_83015 V1270895 RNY S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 Cluster_14175 V1270896 PITRM1 O peptidase COG1026 Cluster_497257 V1270897 S HD domain protein COG1418 Cluster_30004 V1270898 S NA 0YDZN Cluster_12632 V1270900 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_181176 V1270901 AMMA map00360 E amidohydrolase COG1473 Cluster_176158 V1270902 Q amidohydrolase COG1228 Cluster_110759 V1270903 S c4-dicarboxylate anaerobic carrier COG1288 Cluster_135090 V1270904 SERP0565 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_194444 V1270905 METN map02010 P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COG1135 Cluster_342581 V1270906 YEEN K transcriptional regulatory protein COG0217 Cluster_185589 V1270907 YLBM S UPF0348 protein COG1323 Cluster_368692 V1270909 S NA 11VIE Cluster_50578 V1270910 S s-layer domain-containing protein 11ZJU Cluster_26578 V1270911 V Type I restriction-modification system R subunit COG4096 Cluster_51147 V1270912 HSDS V restriction modification system DNA specificity domain COG0732 Cluster_174555 V1270913 C, G Glycosyltransferase COG1819 Cluster_44667 V1270915 NADE map00760,map01100 H Nad synthetase COG0388 Cluster_502461 V1270916 map02010 V ABC transporter COG1132 Cluster_425265 V1270917 S Membrane COG1434 Cluster_285982 V1270918 YABE M domain protein COG3584 Cluster_83016 V1270919 HTRA map03010 M peptidase S1 and S6, chymotrypsin Hap COG0265 Cluster_296830 V1270920 ISPE map00900,map01100,map01110 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COG1947 Cluster_242567 V1270922 GLYQ map00970 J glycyl-tRNA synthetase, alpha subunit COG0752 Cluster_37805 V1270923 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_291344 V1270924 YQFL S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) COG1806 Cluster_126111 V1270925 DNAG map03030 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 Cluster_135900 V1270926 RPOD map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_360484 V1270927 TRMK S SAM-dependent methyltransferase COG2384 Cluster_696129 V1270928 YQFO S dinuclear metal center protein, YbgI family COG0327 Cluster_92374 V1270929 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_52832 V1270930 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_233742 V1270931 NRNA J phosphoesterase RecJ domain protein COG0618 Cluster_37178 V1270932 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_290025 V1270933 UPPP map00550 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) COG1968 Cluster_33640 V1270934 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_596367 V1270935 DIVIC D Septum formation initiator COG2919 Cluster_134297 V1270936 SP_0010 map00311,map00312,map01110,map02020 V Beta-lactamase COG2367 Cluster_135091 V1270937 TILS D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) COG0037 Cluster_44296 V1270938 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_305222 V1270939 V abc transporter related protein COG1131 Cluster_70549 V1270940 S NA 0XP5I Cluster_109448 V1270941 V Mate efflux family protein COG0534 Cluster_234926 V1270942 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_76434 V1270943 map03420 K, L transcription-repair coupling factor COG1197 Cluster_95219 V1270944 SGAT map00053,map01100,map01120,map02060 G PTS system ascorbate-specific transporter subunit IIC COG3037 Cluster_35573 V1270945 CLPL O ATP-dependent Clp protease ATP-binding subunit COG0542 Cluster_458975 V1270947 RAIA J ribosomal subunit Interface protein COG1544 Cluster_212729 V1270949 ATPC map00190,map00680,map01100 C ATP synthase, subunit 0XPA7 Cluster_45367 V1270950 ATPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_58548 V1270951 ATPA map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) COG1155 Cluster_384182 V1270952 ATPD map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG1394 Cluster_116309 V1270954 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_389490 V1270955 S domain protein 0XNZW Cluster_18864 V1270956 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_678962 V1270957 S NA 11YA8 Cluster_92830 V1270958 SLGD_00064 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_122849 V1270960 KTRB P Potassium uptake protein COG0168 Cluster_375356 V1270961 YRRM map00340,map00350,map00360,map00624,map00940,map00941,map00945,map01100,map01110,map01120 S O-methyltransferase COG4122 Cluster_429089 V1270962 MNTP P Probably functions as a manganese efflux pump (By similarity) COG1971 Cluster_751739 V1270963 O Glutaredoxin COG0695 Cluster_20548 V1270965 S Membrane 0XPM4 Cluster_344184 V1270966 S Hydrolase COG1011 Cluster_232480 V1270967 S Cdp-alcohol phosphatidyltransferase 0XQPI Cluster_305223 V1270968 S NA 0YSIM Cluster_112779 V1270969 MURF map00300,map00550,map01100 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) COG0770 Cluster_198921 V1270970 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_410757 V1270971 RECR map03440 L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) COG0353 Cluster_39153 V1270972 PBP2B map00550,map01100 M penicillin-binding protein COG0768 Cluster_280419 V1270973 YVGN C reductase COG0656 Cluster_250344 V1270974 GLYQ map00970 J glycyl-tRNA synthetase, alpha subunit COG0752 Cluster_40240 V1270975 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_370396 V1270976 KTRA P domain protein COG0569 Cluster_147315 V1270977 SP_2122 S Major Facilitator 121QJ Cluster_257764 V1270978 HTPX map00900 O Protease HtpX homolog COG0501 Cluster_429090 V1270979 LEMA S LemA family COG1704 Cluster_342582 V1270980 RSMG M Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) COG0357 Cluster_324587 V1270981 YDFG map00051,map00240,map00363,map00591,map00625,map00650,map01100,map01120 S KR domain COG4221 Cluster_284529 V1270982 CBIQ map02010 P Cobalt transport protein COG0619 Cluster_179523 V1270983 GLGD map00500,map00520,map01100,map01110 M glucose-1-phosphate adenylyltransferase, glgd subunit COG0448 Cluster_534626 V1270985 S NA 121S9 Cluster_231304 V1270986 YHCC S Radical SAM Protein COG1242 Cluster_610738 V1270987 S Protein of unknown function (DUF1292) 1248N Cluster_120632 V1270988 S RelA SpoT domain protein 0XPFE Cluster_324588 V1270989 PPID O Peptidyl-prolyl cis-trans isomerase COG0760 Cluster_461050 V1270990 FOLA map00670,map00790,map01100 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) COG0262 Cluster_389491 V1270993 SG1670 S phage protein COG3646 Cluster_281749 V1270996 SSCG_06117 S degv family COG1307 Cluster_224370 V1270998 DXR map00900,map01100,map01110 I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) COG0743 Cluster_546164 V1270999 VICX map03013 S domain protein COG1235 Cluster_295481 V1271000 CBIO map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_408911 V1271001 CBIQ map02010 P Cobalt abc transporter COG0619 Cluster_227795 V1271002 DDL map00473,map00520,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_649213 V1271003 K Transcriptional regulator COG1737 Cluster_242568 V1271004 FABK map00061,map01100 I 2-Nitropropane dioxygenase COG2070 Cluster_115581 V1271005 RUMA map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_661621 V1271006 YWHA S Pfam:DUF3230 0YTGD Cluster_25603 V1271007 P tonB-dependent Receptor 0XQ03 Cluster_141290 V1271008 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_84292 V1271009 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_283154 V1271010 ISPE map00900,map01100,map01110 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COG1947 Cluster_339608 V1271011 L Membrane COG4905 Cluster_78793 V1271012 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_641233 V1271013 RNPA J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) COG0594 Cluster_363631 V1271014 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins COG0706 Cluster_172911 V1271015 JAG S Single-stranded nucleic acid binding R3H domain-containing protein COG1847 Cluster_124111 V1271016 MNME S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 Cluster_48547 V1271017 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_26677 V1271018 GLTA map00250,map00910,map01100,map01110,map01120,map01230 E glutamate synthase COG0543 Cluster_132665 V1271019 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_10297 V1271020 GBS0396 map03070 U Pfam:TraG COG3505 Cluster_817137 V1271022 SP_1071 S abc transporter atp-binding protein COG1101 Cluster_170355 V1271023 map00300,map01100,map01110,map01120,map01230 E decarboxylase COG0019 Cluster_135901 V1271024 CAPM M Glycosyl transferase (Group 1 0XNZB Cluster_225540 V1271025 S NA 128FT Cluster_199918 V1271026 M group 1 glycosyl transferase COG0438 Cluster_245185 V1271027 PSTS2 map02010,map02020,map05152 P Phosphate-binding protein COG0226 Cluster_363632 V1271028 PHOB map02020 T regulator COG0745 Cluster_665838 V1271031 TRXA O Thioredoxin COG0526 Cluster_132666 V1271032 GRDE S reductase 0XPPI Cluster_80981 V1271034 S NA 12185 Cluster_300891 V1271035 map02010 P Abc transporter COG1120 Cluster_721736 V1271036 S YopX protein 0XUQJ Cluster_272427 V1271037 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_245186 V1271038 RIBF map00740,map01100 H riboflavin biosynthesis protein ribF COG0196 Cluster_34915 V1271039 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_114903 V1271040 RNFC C Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) COG4656 Cluster_117727 V1271044 GOR map00480 C reductase COG1249 Cluster_378914 V1271045 YFNB map00361,map00625,map01100,map01120 S Hydrolase COG1011 Cluster_206164 V1271046 S NA 11IY5 Cluster_309337 V1271047 S Nucleotidyltransferase domain protein 10SIQ Cluster_196988 V1271048 PAAG I Enoyl-CoA hydratase COG1024 Cluster_219651 V1271049 S HTH_XRE 0ZJRR Cluster_24825 V1271050 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_231305 V1271051 COBD map00860,map01100 H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) COG1270 Cluster_154476 V1271052 IADA S Isoaspartyl dipeptidase 0XNTK Cluster_125424 V1271053 RUMA map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_96309 V1271055 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_64291 V1271056 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_39309 V1271057 S S-layer domain protein 0XS72 Cluster_83809 V1271058 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_9493 V1271059 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_130368 V1271060 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_18049 V1271061 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_99505 V1271062 S gumn family COG3735 Cluster_216171 V1271063 LTAE map00260,map01100,map01110,map01120,map01230 E Aldolase COG2008 Cluster_164510 V1271064 S filamentation induced by cAMP protein Fic COG3177 Cluster_246526 V1271065 ACTP P copper-exporting ATPase COG2217 Cluster_131913 V1271066 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_251565 V1271067 YOJN S ATPase associated with various cellular activities aaa_5 COG0714 Cluster_670141 V1271068 S NA 0XWEM Cluster_546165 V1271069 MAMA map00280,map00640,map00660,map00720,map01100,map01120 E Glutamate mutase subunit sigma COG2185 Cluster_110069 V1271070 MUTL2 map00660,map01100 S glutamate mutase, mutL 0XRSI Cluster_133502 V1271071 map00660,map01100 E Methylaspartate ammonia-lyase COG3799 Cluster_111443 V1271072 S Protein of unknown function (DUF1446) 0ZVCR Cluster_657427 V1271073 S NA 124GJ Cluster_57029 V1271074 MDLA V ABC transporter COG1132 Cluster_41044 V1271075 ABCB map02010 V Abc transporter COG1132 Cluster_236128 V1271077 PURC map00230,map01100,map01110 F SAICAR synthetase COG0152 Cluster_294072 V1271078 S NA 11J85 Cluster_223178 V1271079 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_220848 V1271080 BIRA map00780,map01100 H biotin acetyl-CoA-carboxylase ligase COG0340 Cluster_649214 V1271081 YAAQ S protein from nitrogen regulatory protein P-II COG3870 Cluster_711813 V1271082 YAAQ S protein from nitrogen regulatory protein P-II COG3870 Cluster_239912 V1271083 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG2812 Cluster_251566 V1271085 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_109449 V1271086 LPXC map00061,map00540,map01100 M involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) COG0774 Cluster_199919 V1271087 LPXD map00540,map01100 M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) COG1044 Cluster_755208 V1271089 O Glutaredoxin 125U3 Cluster_19672 V1271091 L Inherit from COG: helicase 0XPYJ Cluster_202947 V1271092 RLUC J Pseudouridine synthase COG0564 Cluster_49592 V1271095 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_494749 V1271096 GREA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) COG0782 Cluster_243913 V1271097 DUSB J Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_24068 V1271098 map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_3723 V1271099 U, W Inherit from COG: domain protein 121KM Cluster_13830 V1271100 U, W surface protein COG5295 Cluster_596368 V1271101 CTPC map00190 P heavy metal translocating P-type ATPase COG2217 Cluster_576645 V1271102 S NA 0ZTGB Cluster_66865 V1271103 PHOR map02020 T Histidine kinase 0XNMH Cluster_228959 V1271104 PSTS2 map02010,map02020,map05152 P Phosphate-binding protein COG0226 Cluster_94177 V1271105 CAS3 L CRISPR-Associated Helicase Cas3 COG1203 Cluster_46356 V1271106 CSD1 L CRISPR-associated protein Csd1 family 0ZVNC Cluster_276440 V1271107 L CRISPR-associated protein Csd2 COG3649 Cluster_492258 V1271109 LLMG_0050 L IstB domain-containing protein ATP-binding protein COG1484 Cluster_215031 V1271110 RBSR K Transcriptional regulator, LacI family COG1609 Cluster_456994 V1271111 L Integrase core domain protein COG2801 Cluster_400082 V1271112 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_17975 V1271113 MGTA P magnesium-translocating p-type atpase COG0474 Cluster_7602 V1271114 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_249091 V1271116 SERA map00260,map00680,map01100,map01120,map01230 C dehydrogenase COG0111 Cluster_184715 V1271117 SERC map00260,map00680,map00750,map01100,map01120,map01230 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) COG1932 Cluster_28572 V1271118 S NA 0YH7P Cluster_31849 V1271119 LKTB3 V ABC transporter, ATP-binding protein COG2274 Cluster_24826 V1271121 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_711814 V1271122 YICC map03010 S YicC domain protein COG1561 Cluster_321444 V1271123 S NA 0YYM2 Cluster_210509 V1271124 CARA map00240,map00250,map01100 F carbamoyl-phosphate synthetase glutamine chain COG0505 Cluster_140532 V1271126 S CHAP domain 0ZJI2 Cluster_475880 V1271129 ARGR K Regulates arginine biosynthesis genes (By similarity) COG1438 Cluster_209427 V1271130 ARCB map00330,map01100,map01110,map01230 E ornithine carbamoyltransferase COG0078 Cluster_237323 V1271131 S (LipO)protein 0Y5X3 Cluster_32856 V1271132 PTSG map00010,map00500,map00520,map02060 G PTS System COG2190 Cluster_294073 V1271133 RGFB S Endonuclease Exonuclease phosphatase COG3568 Cluster_429091 V1271134 S NA 11H4D Cluster_18050 V1271135 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_852045 V1271136 NLAXM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_243914 V1271138 CYSK map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_7839 V1271139 S NA 11YT1 Cluster_104012 V1271141 GLCD map00620,map00630,map01100,map01110,map01120 C FAD linked oxidase domain-containing protein COG0277 Cluster_357163 V1271142 MTGA map00550 M Monofunctional biosynthetic peptidoglycan transglycosylase COG0744 Cluster_188201 V1271143 map00051,map00520,map01100 M RmlD substrate binding domain COG1089 Cluster_152070 V1271144 FCL map00051,map00520,map01100 M Nad-dependent epimerase dehydratase COG0451 Cluster_82131 V1271145 XYLG S ABC transporter COG3845 Cluster_216172 V1271146 ANSA map00250,map00460,map00910,map01100,map01110 E L-asparaginase COG0252 Cluster_73868 V1271147 UDK map00240,map00983,map01100 F uridine kinase COG0572 Cluster_220849 V1271148 L Inherit from COG: helicase 0XPYJ Cluster_100027 V1271150 GLGA map00500,map01100,map01110,map04973 G Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) COG0297 Cluster_302264 V1271151 S NA 0YG6V Cluster_211638 V1271152 S NA 0YUNN Cluster_313798 V1271154 K Peptidase S24-like protein COG2932 Cluster_194445 V1271155 RUMAL_2694 S DNA repair protein RadA domain 0ZP7K Cluster_45368 V1271156 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_14746 V1271157 YLBB V abc transporter permease protein COG0577 Cluster_37023 V1271158 S NA 11HZH Cluster_228960 V1271159 PRSA O Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) COG0760 Cluster_7402 V1271160 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_144243 V1271161 map00051 M glycosyl transferase 11GWY Cluster_41844 V1271162 FBP map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120 G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 COG3855 Cluster_34781 V1271163 COPA P p-type ATPase COG2217 Cluster_433078 V1271164 YFCE S Phosphodiesterase COG0622 Cluster_59353 V1271166 S conserved domain protein 11Q3F Cluster_165361 V1271169 PATB map00270,map00450,map00920,map01100,map01110,map01230 E Aminotransferase class I and II COG1168 Cluster_279098 V1271170 S YitT family COG1284 Cluster_94178 V1271171 GCVPB map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG1003 Cluster_117017 V1271172 GCVPA map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG0403 Cluster_189045 V1271173 S NA 122PE Cluster_159565 V1271174 S AAA ATPase COG1373 Cluster_6754 V1271175 NIFJ map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map00910,map01100,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_439070 V1271176 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_7124 V1271177 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_526230 V1271178 S acetyltransferase, (GNAT) family 121KY Cluster_653297 V1271179 S NA 0ZS73 Cluster_13831 V1271180 SPEB S peptidase C10 11SDT Cluster_117018 V1271181 MURD map00471,map00550,map01100 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COG0771 Cluster_52833 V1271182 TYPA T gtp-binding protein typa COG1217 Cluster_338186 V1271183 RSUA J Pseudouridine synthase COG1187 Cluster_583011 V1271184 YQHL P rhodanese family COG0607 Cluster_455055 V1271185 DPS P DNA protection during starvation protein COG0783 Cluster_73869 V1271186 YBIT S ABC transporter, ATP-binding protein COG0488 Cluster_239913 V1271187 RLUD J Pseudouridine synthase COG0564 Cluster_393027 V1271189 S HD domain protein 11N5F Cluster_661622 V1271190 S Single-strand binding protein 11IEM Cluster_781377 V1271191 S NA 11TQ2 Cluster_592897 V1271192 S NA 11KDE Cluster_25705 V1271193 TRSE U traE protein COG3451 Cluster_34916 V1271194 S nlpC P60 family protein 0ZVM8 Cluster_122175 V1271196 HLYX P Domain of unknown function DUF21 COG1253 Cluster_478070 V1271197 COAD map00770,map01100 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) COG0669 Cluster_453035 V1271198 K RNA Polymerase COG1595 Cluster_5674 V1271199 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_124112 V1271200 S radical SAM domain protein COG0641 Cluster_762517 V1271201 NRDG O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) COG0602 Cluster_372024 V1271202 D Conjugative transposon protein TraA 11VDK Cluster_188202 V1271203 FOPA M ompA family 10ZT3 Cluster_21627 V1271204 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_57280 V1271205 YDAO E amino acid COG0531 Cluster_91877 V1271206 map03440 L ATP-dependent exodnase (exonuclease v) COG0507 Cluster_377133 V1271207 PYRE map00240,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_785470 V1271208 S UPF0346 protein COG4479 Cluster_187345 V1271209 PHOH T Phoh family COG1702 Cluster_480470 V1271210 ALD map00250,map00430,map01100 E alanine dehydrogenase COG0686 Cluster_288741 V1271211 map00510,map01100 M GtrA-like protein COG0463 Cluster_407136 V1271212 BL03733 map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_276441 V1271213 LIVH map02010 E branched-chain amino acid ABC transporter, permease COG0559 Cluster_665840 V1271214 SMU_1348C V ABC transporter, ATP-binding protein COG1136 Cluster_120633 V1271215 PEPC E aminopeptidase c COG3579 Cluster_290026 V1271216 NADE map00760,map01100 H nh(3)-dependent nad( ) synthetase COG0171 Cluster_375357 V1271218 LANM V Lanthionine synthetase C family protein COG4403 Cluster_339609 V1271219 map02010 S NA 11HWF Cluster_330546 V1271220 map02010 S NA 11ISF Cluster_243915 V1271221 BCRA map02010 V ABC transporter COG1131 Cluster_209428 V1271222 S NA 11J2B Cluster_363633 V1271223 S Helix-turn-helix 0XT0B Cluster_218504 V1271224 K AraC Family Transcriptional Regulator COG2207 Cluster_74825 V1271226 map02010 V ABC transporter COG1132 Cluster_41387 V1271227 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_54038 V1271229 CLPE O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_148107 V1271232 map00627,map00790,map01100,map01120,map02020 S associated with various cellular activities COG0714 Cluster_576646 V1271234 DINF V Mate efflux family protein COG0534 Cluster_344185 V1271235 S caax amino terminal protease family protein COG1266 Cluster_728404 V1271236 IR2 map02020 T response regulator COG3279 Cluster_130369 V1271237 AGRC map02020 T Histidine kinase COG2972 Cluster_312302 V1271238 PUNA map00230,map00240,map00760,map01100,map01110 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) COG0005 Cluster_68905 V1271240 YLOV S dak2 domain fusion protein ylov COG1461 Cluster_40549 V1271241 RECG map03440 L ATP-dependent DNA helicase recg COG1200 Cluster_429092 V1271242 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_441069 V1271243 S NA 11NM2 Cluster_46357 V1271245 P tonB-dependent Receptor 0XQNF Cluster_164511 V1271246 RDGB map00230,map00240,map01100 F Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) COG0127 Cluster_218505 V1271247 FEMA map00550,map01100 V Methicillin resistance protein COG2348 Cluster_859880 V1271248 map00240,map00250,map01100 E, F Carbamoyl phosphate synthase-like protein COG0458 Cluster_256479 V1271249 C reductase COG0656 Cluster_306602 V1271250 S NA 0ZWIA Cluster_738257 V1271251 S NA 11HT5 Cluster_625648 V1271252 RPLV map03010 J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) COG0091 Cluster_599866 V1271253 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_596369 V1271254 K Transcriptional regulator 11VTG Cluster_482801 V1271257 S NA 0XYQ4 Cluster_172912 V1271258 map00051 M glycosyl transferase group 1 COG0438 Cluster_265714 V1271259 S membrAne 0YEM5 Cluster_387773 V1271260 TRMB C Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_302265 V1271261 YTMP M phosphotransferase enzyme family COG0510 Cluster_198922 V1271262 ECSB U (ABC) transporter COG4473 Cluster_335108 V1271263 ECSA V abc transporter atp-binding protein COG1131 Cluster_70246 V1271264 PEPD E Dipeptidase COG4690 Cluster_264386 V1271265 CAS1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) COG1518 Cluster_19451 V1271266 SCLAV_4759 L DNA helicase COG1112 Cluster_74500 V1271267 RIMO J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) COG0621 Cluster_429093 V1271268 CINA H cina domain protein COG1546 Cluster_260399 V1271270 map00230,map00240,map01100,map03030,map03430,map03440 L EXOIII COG2176 Cluster_338187 V1271271 NADE map00760,map01100 H nh(3)-dependent nad( ) synthetase COG0171 Cluster_353780 V1271272 DEOC map00030 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) COG0274 Cluster_71835 V1271273 S NA 0ZZP4 Cluster_169484 V1271274 L Dna topoisomerase COG0550 Cluster_256480 V1271277 S NA 11QFA Cluster_14747 V1271278 O cysteine protease COG4870 Cluster_66583 V1271279 S CAMP factor (Cfa) 0Z1YX Cluster_330547 V1271280 P Citrate transporter COG1055 Cluster_391220 V1271281 VANZ V VanZ-like protein COG4767 Cluster_24364 V1271283 TRAG2 S conjugation system ATPase, TraG family 0XSHU Cluster_543233 V1271285 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_96311 V1271286 MUTE map00660,map01100 E Methylaspartate mutase, E subunit COG4865 Cluster_144992 V1271287 map00660,map01100 E Methylaspartate ammonia-lyase COG3799 Cluster_705549 V1271288 CITE map00020,map01110,map02020 C Citrate lyase beta COG2301 Cluster_394843 V1271289 NTH map03410 L endonuclease III COG0177 Cluster_256481 V1271290 S Abortive infection protein 11SQ4 Cluster_387774 V1271291 SDPI S Membrane COG5658 Cluster_389492 V1271292 S Membrane COG2323 Cluster_423459 V1271294 RNFA C Electron transport complex COG4657 Cluster_232481 V1271295 RNFD C Electron transport complex COG4658 Cluster_104013 V1271296 APPA E Extracellular solute-binding protein, family 5 COG0747 Cluster_197929 V1271297 S Nucleotidyl transferase of unknown function (DUF1814) 0ZWCV Cluster_206165 V1271299 S NA 101UU Cluster_233743 V1271300 CBPA O DnaJ domain protein COG2214 Cluster_20223 V1271301 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_338188 V1271302 CLVE map02010 S NA 11PT3 Cluster_313799 V1271303 S NA 0YFZU Cluster_515338 V1271304 T response regulator 11GEV Cluster_58806 V1271305 L Domain protein COG0507 Cluster_191688 V1271306 PRFA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) COG0216 Cluster_294074 V1271307 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_254038 V1271308 YQHQ J Metal-dependent enzyme COG3872 Cluster_400083 V1271309 S peptidase, S41 11U77 Cluster_414442 V1271311 M Cell Wall COG2866 Cluster_718427 V1271313 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_173735 V1271314 K, T Peptidase M56 COG4219 Cluster_198923 V1271315 SUFB O SufB sufD domain protein COG0719 Cluster_110760 V1271316 SUFB O FeS assembly protein SUFB COG0719 Cluster_372025 V1271317 SUFC O feS assembly ATPase SufC COG0396 Cluster_87697 V1271320 map00400,map01100,map01110,map01230 E shikimate COG0703 Cluster_523325 V1271321 AROQ map00400,map01051,map01100,map01110,map01230 E Catalyzes a trans-dehydration via an enolate intermediate (By similarity) COG0757 Cluster_367068 V1271322 PABC map00280,map00290,map00310,map00330,map00360,map00472,map00473,map00770,map00790,map01100,map01110,map01210,map01230 E brancheD-chain amino acid aminotransferase COG0115 Cluster_313800 V1271323 GUFA P Mediates zinc uptake. May also transport other divalent cations (By similarity) COG0428 Cluster_45369 V1271324 FBP map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120 G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 COG3855 Cluster_132667 V1271325 S -dicarboxylate symporter COG1823 Cluster_133503 V1271326 ELI_1297 O phage portal protein HK97 family COG4695 Cluster_773880 V1271327 S NA 0ZXT9 Cluster_193513 V1271328 S NA 16SE4@proNOG Cluster_429094 V1271329 AHPC O C-terminal domain of 1-Cys peroxiredoxin COG0450 Cluster_89524 V1271330 SP_0374 S NA 0YUH9 Cluster_160410 V1271331 YPSC L Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) COG0116 Cluster_276442 V1271333 AROE map00400,map01100,map01110,map01230 E shikimate dehydrogenase COG0169 Cluster_181177 V1271334 TYRA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydrogenase COG0287 Cluster_117728 V1271335 S NA 11H5S Cluster_237324 V1271336 RIBF map00740,map01100 H riboflavin biosynthesis protein ribF COG0196 Cluster_344186 V1271338 PYRK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) COG0543 Cluster_423460 V1271339 GMK2 map00230,map01100 F Guanylate kinase COG0194 Cluster_341060 V1271340 K Transcriptional regulator, ARAC family COG2207 Cluster_125425 V1271341 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_128204 V1271342 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_330548 V1271343 NPDA map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_884418 V1271344 SATD S SatD protein 11X9Q Cluster_362063 V1271345 SATE S membrane 11JZR Cluster_418023 V1271346 SP_0743 K Transcriptional regulator COG1309 Cluster_499920 V1271347 COMEB map00240,map01100 F deaminase COG2131 Cluster_99506 V1271348 ALGI M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_268443 V1271349 YEIE K Transcriptional regulator, LysR family COG0583 Cluster_755209 V1271351 GALE map00052,map00520,map01100,map01110 M udp-glucose 4-epimerase COG1087 Cluster_198924 V1271352 RFBB map00521,map00523,map01055,map01100,map01110 M dtdp-glucose 4,6-dehydratase COG1088 Cluster_183837 V1271353 YURR map00360,map00730 E oxidoreductase COG0665 Cluster_302266 V1271354 YQFO S dinuclear metal center protein, YbgI family COG0327 Cluster_88134 V1271355 C Hydrogenase large subunit domain protein COG4624 Cluster_228961 V1271357 S hi0933 family COG2081 Cluster_10845 V1271358 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_300892 V1271360 map00230,map00240,map00760,map01100,map01110 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) COG0005 Cluster_157842 V1271361 M Sulfatase COG1368 Cluster_31508 V1271362 LKTB3 V ABC transporter, ATP-binding protein COG2274 Cluster_55999 V1271363 SP_1358 map02010 V ABC transporter COG1132 Cluster_83810 V1271364 SP_1282 S abc transporter atp-binding protein COG0488 Cluster_302267 V1271365 GLNQ map02010 E (ABC) transporter COG1126 Cluster_7014 V1271366 S domain protein 0XS27 Cluster_242569 V1271367 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_295482 V1271368 SP_1245 S hydrolase COG0561 Cluster_90922 V1271369 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_90923 V1271370 ZWF map00030,map00480,map01100,map01110,map01120 G glucose-6-phosphate 1-dehydrogenase COG0364 Cluster_398361 V1271371 G Major Facilitator COG0477 Cluster_88585 V1271372 SCLAV_1000 S TPR-repeat-containing protein 10GX4 Cluster_242570 V1271373 RIBF map00740,map01100 H riboflavin biosynthesis protein ribF COG0196 Cluster_560951 V1271374 SPXA K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) COG1393 Cluster_128205 V1271375 SUN map00340,map00350,map00624,map01120 J NOL1 NOP2 sun family protein COG3270 Cluster_271096 V1271376 PSTS map02010,map02020,map05152 P phosphate COG0226 Cluster_405477 V1271377 S NA 17JPI@proNOG Cluster_184716 V1271379 YXBA S ATP-grasp COG3919 Cluster_387775 V1271380 THIN map00730,map01100 H thiamine COG1564 Cluster_277747 V1271381 RSGA G May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) COG1162 Cluster_342583 V1271382 STP T Phosphatase COG0631 Cluster_461051 V1271383 S NA 11FVY Cluster_26993 V1271384 PPSA map00620,map00680,map00720,map01100,map01120 G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) COG0574 Cluster_302268 V1271385 S NA 0ZPIA Cluster_828770 V1271386 S domain protein 12C1H Cluster_71522 V1271387 YLOV S dak2 domain fusion protein ylov COG1461 Cluster_41045 V1271388 RECG map03440 L ATP-dependent DNA helicase recg COG1200 Cluster_489766 V1271389 COAD map00770,map01100 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) COG0669 Cluster_480471 V1271390 NTPF S H -ATPase, subunit H 122TR Cluster_621856 V1271391 S NA COG3461 Cluster_149603 V1271392 OPUCA map02010 E ABC transporter COG1125 Cluster_11326 V1271393 S Rib/alpha-like repeat 10008 Cluster_520583 V1271394 YQEY S gatB Yqey COG1610 Cluster_277748 V1271395 S phospholipase COG4667 Cluster_30717 V1271396 S Protein of unknown function (DUF3160) 0XRJH Cluster_451109 V1271397 S Nitroreductase 11NZA Cluster_213839 V1271398 YBHK S UPF0052 protein COG0391 Cluster_18603 V1271399 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_449126 V1271402 S peptidase M15 0Y4QW Cluster_124113 V1271403 S Abortive infection protein COG1106 Cluster_357164 V1271404 S NA 0Y3NA Cluster_89525 V1271405 WS0013 S membrAne 0XPGN Cluster_342584 V1271406 COBA map00860,map01100,map01110 H Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) COG0007 Cluster_120634 V1271407 ICTB M O-Antigen polymerase COG3307 Cluster_119151 V1271410 NNRD G Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) COG0063 Cluster_135902 V1271411 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_3984 V1271412 S S-layer domain protein 0XRBV Cluster_396622 V1271413 S NA 1224P Cluster_247776 V1271414 S Relaxase mobilization nuclease 11PW0 Cluster_243916 V1271415 L DNA primase 11GUV Cluster_88135 V1271416 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_576647 V1271418 S NA 11NGD Cluster_73870 V1271419 SUN map00340,map00350,map00624,map01120 J NOL1 NOP2 sun family protein COG0144 Cluster_146532 V1271420 S Filamentation induced by cAMP protein fic COG3177 Cluster_49593 V1271421 UUP S Abc transporter COG0488 Cluster_1812 V1271422 S NA 0ZTYV Cluster_785472 V1271423 RPLE map03010 J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COG0094 Cluster_208390 V1271425 S sporulation and cell division repeat protein 11WNU Cluster_1771 V1271426 O cysteine protease COG4870 Cluster_54040 V1271427 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_142016 V1271428 BAPKO_0207 P CBS domain protein COG1253 Cluster_271097 V1271431 S Inherit from NOG: Leucine rich repeat protein, bspa family protein 0Y4NF Cluster_480472 V1271432 S hemerythrin hhe cation binding domain protein COG3945 Cluster_57521 V1271433 V ABC transporter transmembrane region COG1132 Cluster_168557 V1271434 S Acyl-transferase 0XPHK Cluster_103444 V1271435 S Phospholipase D endonuclease domain-containing protein 0Z3N0 Cluster_21313 V1271437 ACTP P copper-exporting ATPase COG2217 Cluster_26579 V1271438 CADA P heavy metal translocating p-type ATPase COG2217 Cluster_18604 V1271439 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_199920 V1271440 APPB P ABC transporter (Permease COG0601 Cluster_152905 V1271441 S F420-0:Gamma-glutamyl ligase 0Y085 Cluster_58807 V1271443 HYMB map00190,map00910,map01100 C NADH dehydrogenase COG1894 Cluster_61820 V1271444 map00190,map00910,map01100 C hydrogenase) (Fe-only COG4624 Cluster_75174 V1271445 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_80982 V1271446 S fad dependent oxidoreductase COG2509 Cluster_210510 V1271447 HOLA map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii, delta' subunit COG1466 Cluster_26784 V1271448 COMEC S DNA internalization-related competence protein ComEC Rec2 COG2333 Cluster_515339 V1271449 S Gcn5-related n-acetyltransferase 123BS Cluster_173736 V1271451 S Inherit from COG: Membrane COG3949 Cluster_105818 V1271452 SELA map00450,map00970 E Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) COG1921 Cluster_323004 V1271453 NFED O nodulation efficiency protein D COG1030 Cluster_113518 V1271454 CWLV M n-acetylmuramoyl-l-alanine amidase COG0860 Cluster_219652 V1271455 HYPE O hydrogenase expression formation protein (HypE) COG0309 Cluster_641235 V1271457 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_102809 V1271458 HFLX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COG2262 Cluster_8795 V1271459 map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_211639 V1271460 ISPG map00900,map01100,map01110 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) COG0821 Cluster_603467 V1271461 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_121411 V1271462 KTRB P Potassium uptake protein COG0168 Cluster_335109 V1271463 SPOU J rrna methyltransferase COG0566 Cluster_52834 V1271464 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_53291 V1271467 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_58549 V1271468 TOPB L Dna topoisomerase COG0550 Cluster_126112 V1271469 SPOIID D SpoIID LytB domain protein COG2385 Cluster_370397 V1271470 NFED O nodulation efficiency protein D COG1030 Cluster_162068 V1271472 OCAR_7462 map00270,map00450,map01100,map01110,map01230 E Methionine synthase COG0620 Cluster_178657 V1271473 ACD map00071,map00280,map00281,map00362,map00410,map00640,map00650,map01100,map01110,map01120,map03320 I Acyl-CoA dehydrogenase, C-terminal domain COG1960 Cluster_176973 V1271474 ACD map00071,map00280,map00281,map00362,map00410,map00640,map00650,map01100,map01110,map01120,map03320 I Acyl-CoA dehydrogenase, C-terminal domain COG1960 Cluster_168558 V1271475 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_137498 V1271476 S abc transporter atp-binding protein 11HXT Cluster_439071 V1271477 S prophage antirepressor 17798@proNOG Cluster_119152 V1271478 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_92375 V1271479 SP_0341 S UPF0371 protein COG4868 Cluster_306603 V1271482 M n-acetylmuramoyl-l-alanine amidase COG5632 Cluster_341061 V1271485 L integrase family COG4974 Cluster_117729 V1271486 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01230 G phosphohexose isomerase COG0166 Cluster_87276 V1271487 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_223179 V1271488 RLMB map00340,map00350,map00624,map01120 J RNA methyltransferase TrmH family group 3 COG0566 Cluster_169485 V1271489 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_272428 V1271491 CTPA M protease COG0793 Cluster_3152 V1271492 S NA 11MTE Cluster_389493 V1271494 SP_0899 S Membrane Associated 114SZ Cluster_168559 V1271495 G abc transporter integral membrane protein COG1172 Cluster_76436 V1271496 map02010 G ABC transporter COG1129 Cluster_549196 V1271497 AROQ map00400,map01051,map01100,map01110,map01230 E Catalyzes a trans-dehydration via an enolate intermediate (By similarity) COG0757 Cluster_199921 V1271498 YHFE E m42 family COG1363 Cluster_4666 V1271499 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_54041 V1271500 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_177815 V1271501 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_246527 V1271502 PRMA J Methylates ribosomal protein L11 (By similarity) COG2264 Cluster_755210 V1271503 MAZG map00230,map00240,map01100 F mazG family COG1694 Cluster_17014 V1271504 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_156122 V1271505 S Clostripain family 0YH96 Cluster_661623 V1271506 S radical SAM domain protein 125RF Cluster_176159 V1271507 YPSC L Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) COG0116 Cluster_256482 V1271508 PLDB map00564 I alpha beta COG2267 Cluster_326086 V1271509 CUTC P copper homeostasis protein cutc COG3142 Cluster_332090 V1271510 K transcriptional regulator 11X9R Cluster_144993 V1271511 G Major Facilitator COG0477 Cluster_24472 V1271512 M Lpxtg-motif cell wall anchor domain protein 0XQ9I Cluster_725083 V1271513 SERA map00260,map00680,map01100,map01120,map01230 C dehydrogenase COG0111 Cluster_60970 V1271514 map00190,map00910,map01100 C hydrogenase) (Fe-only COG4624 Cluster_41046 V1271516 M Inherit from COG: YD repeat protein COG3209 Cluster_549197 V1271517 S NA 0YIA5 Cluster_880283 V1271519 K SpoVT_AbrB 11S16 Cluster_122176 V1271520 S NA 0XQNQ Cluster_327648 V1271521 L DNA methylase n-4 n-6 domain protein COG0863 Cluster_434981 V1271523 S Lema protein COG1704 Cluster_373647 V1271525 S Protein of unknown function (DUF541) 0YM36 Cluster_136709 V1271526 S Inherit from COG: ATPase (AAA COG1373 Cluster_494750 V1271527 CDR P pyridine nucleotide-disulfide oxidoreductase COG0607 Cluster_696130 V1271528 RPMA map03010 J 50S ribosomal protein l27 COG0211 Cluster_28671 V1271530 FTSK D cell division protein FtsK COG1674 Cluster_824975 V1271531 YYBC S integral membrane protein 0ZWZF Cluster_42421 V1271532 RECG map03440 L ATP-dependent DNA helicase recG COG1200 Cluster_108818 V1271533 SP_1997 S COF family COG4696 Cluster_699402 V1271534 ASPC map00250,map00290,map01100,map01110,map01210,map01230 E Aminotransferase COG0436 Cluster_114233 V1271536 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_97898 V1271537 FTSA map04112 D This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) COG0849 Cluster_499921 V1271538 S NA 11JHF Cluster_367069 V1271539 YLME F alanine racemase domain protein COG0325 Cluster_45182 V1271540 S peptidase family M49 0XRK4 Cluster_471613 V1271541 FURR P ferric uptake regulator COG0735 Cluster_880284 V1271542 PURA map00230,map00250,map01100 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis COG0104 Cluster_219653 V1271544 GLPQ map00564 C glycerophosphoryl diester phosphodiesterase COG4781 Cluster_319962 V1271545 THYX map00240,map00340,map00350,map00624,map00670,map01120 F Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) COG1351 Cluster_437048 V1271546 YACP J Tetracycline resistance protein COG3688 Cluster_139017 V1271547 S domain protein 0ZZY0 Cluster_179524 V1271548 S domain protein 0ZZY0 Cluster_155309 V1271549 S domain protein 0ZZY0 Cluster_125426 V1271550 DBPA L dEAD DEAH box helicase COG0513 Cluster_131144 V1271551 RMUC S RmuC domain protein COG1322 Cluster_237325 V1271552 YHAM S Metal Dependent Phosphohydrolase COG3481 Cluster_324589 V1271553 SPD S Prophage Lp1 protein 65 0XSDQ Cluster_199922 V1271554 FNI map00900,map01100,map01110 C Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) COG1304 Cluster_135092 V1271555 MVK map00900,map01100,map01110,map04146 I mevalonate kinase COG1577 Cluster_15408 V1271556 S NA 11QZ9 Cluster_11756 V1271557 HSDR V Type I Restriction COG0610 Cluster_8591 V1271558 SP_1221 V restriction 0XQ8K Cluster_281750 V1271559 UPPP map00550 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) COG1968 Cluster_79800 V1271560 GLNP E ABC transporter COG0834 Cluster_84726 V1271561 map02010 V ABC transporter COG1132 Cluster_171171 V1271562 NNRD G Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) COG0736 Cluster_71243 V1271563 FTSK D cell division protein FtsK COG1674 Cluster_140533 V1271564 RIMO J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) COG0621 Cluster_451110 V1271565 PGSA map00564,map01100 I cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase COG0558 Cluster_473705 V1271566 NODN I Dehydratase COG2030 Cluster_168560 V1271567 MRDA map00550 M Penicillin-binding protein 2 COG0768 Cluster_306604 V1271568 S Hydrolase COG0561 Cluster_335110 V1271569 P Transporter COG0733 Cluster_260400 V1271570 FDA map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01230 G fructose-bisphosphate aldolase COG3588 Cluster_653299 V1271571 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01230 G phosphohexose isomerase COG0166 Cluster_419807 V1271572 C Nitroreductase COG0778 Cluster_46931 V1271573 ACDA map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I Acyl-coa dehydrogenase COG2025 Cluster_702441 V1271574 PGN_0051 S NA 0YP2S Cluster_65996 V1271575 NIST map02010 V ABC transporter 0XPIZ Cluster_2323 V1271576 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG4412 Cluster_73871 V1271577 ATPA map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_540307 V1271578 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_748304 V1271579 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_28771 V1271580 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_225541 V1271581 NRNA J phosphoesterase RecJ domain protein COG0618 Cluster_360485 V1271582 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_263006 V1271583 DAPA map00300,map01100,map01110,map01120,map01230 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) COG0329 Cluster_186508 V1271584 ANSA map00250,map00460,map00910,map01100,map01110 E L-asparaginase COG0252 Cluster_303710 V1271586 S Nitroreductase 11QVA Cluster_118418 V1271587 MGTE P magnesium transporter COG2239 Cluster_431062 V1271588 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_46530 V1271589 S NA 0YDZN Cluster_171996 V1271591 BCOA_0505 L transposase COG0675 Cluster_279099 V1271594 map00051,map00520,map01100,map02060 G PTS System COG3715 Cluster_449127 V1271595 map00051,map00520,map01100,map02060 G PTS System COG3444 Cluster_132668 V1271596 G solute-binding protein COG1653 Cluster_284530 V1271598 U MotA TolQ exbB proton channel COG0811 Cluster_139018 V1271599 S NA 120K9 Cluster_313801 V1271600 TATD L Hydrolase, tatD family COG0084 Cluster_36147 V1271601 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_5392 V1271602 PULA map00500,map01100,map04973 G pullulanase COG1523 Cluster_345798 V1271603 S TIGR02453 family COG5587 Cluster_62636 V1271604 MDLA V ABC transporter COG1132 Cluster_48548 V1271605 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_130370 V1271606 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_510041 V1271607 KDSC map00540,map01100 M 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase COG1778 Cluster_280421 V1271608 S NADP oxidoreductase coenzyme f420-dependent 0ZHKD Cluster_224371 V1271609 S NA 11UTX Cluster_201904 V1271610 GALE map00052,map00520,map01100,map01110 M udp-glucose 4-epimerase COG1087 Cluster_91878 V1271611 S Domain of unknown function DUF87 0ZJHN Cluster_797228 V1271612 RECO map03440 L Involved in DNA repair and RecF pathway recombination (By similarity) COG1381 Cluster_251567 V1271613 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_549199 V1271614 CDD map00240,map00983,map01100,map05219 F cytidine deaminase COG0295 Cluster_507444 V1271615 YBEY map00240,map00983,map01100 F Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) COG0319 Cluster_213840 V1271616 PHOH T Phoh family COG1702 Cluster_429095 V1271617 ENTB Q Isochorismatase, hydrolase 11I3F Cluster_423461 V1271618 PROTEASE map05120 O peptidase, U32 COG0826 Cluster_26153 V1271619 MUTS2 map03430 L muts2 protein COG1193 Cluster_64292 V1271620 ARGS map00970 J Arginyl-tRNA synthetase COG0018 Cluster_312304 V1271621 S NA 0Y8QF Cluster_72170 V1271622 PPAC map00190 C Manganese-dependent inorganic pyrophosphatase COG1227 Cluster_59893 V1271624 S Membrane 0ZI5H Cluster_63187 V1271625 map02010 V ABC superfamily ATP binding cassette transporter, ABC membrane protein COG1132 Cluster_175364 V1271626 S NA 0ZMA4 Cluster_40241 V1271627 S Siphovirus protein of unknown function (DUF859) 11YW7 Cluster_292689 V1271628 M Bacteriophage peptidoglycan hydrolase COG0791 Cluster_85128 V1271629 ERIC P Chloride channel COG0038 Cluster_108205 V1271630 BMUL_5818 C Iron-sulfur cluster binding protein COG1139 Cluster_196174 V1271631 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_52143 V1271632 FTSK D cell division protein FtsK COG1674 Cluster_24190 V1271633 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_71523 V1271634 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_144244 V1271635 DNAG map03030 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 Cluster_80591 V1271636 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_362064 V1271637 S RelA SpoT domain protein COG2357 Cluster_189046 V1271638 DPRA L DNA protecting protein DprA COG0758 Cluster_37953 V1271639 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_375358 V1271640 GSPE map03070 U type II secretion system protein E COG2804 Cluster_670142 V1271641 XENA map00627,map01120 C flavin oxidoreductase COG1902 Cluster_63757 V1271642 S copper amine 0XP8R Cluster_718428 V1271643 S NA 1258Z Cluster_226661 V1271644 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_75175 V1271645 HSDM V type I restriction-modification system COG0286 Cluster_586208 V1271646 V type i restriction modification DNA specificity domain protein COG0732 Cluster_26895 V1271650 MUTS2 map03430 L muts2 protein COG1193 Cluster_43897 V1271651 KUP P Transport of potassium into the cell (By similarity) COG3158 Cluster_53292 V1271653 L DNA polymerase COG3344 Cluster_751740 V1271654 S Ser Thr phosphatase family protein 11JEF Cluster_154477 V1271656 map00040,map01100 G dehydratase COG2721 Cluster_4874 V1271657 V abc transporter permease protein COG0577 Cluster_560952 V1271658 S NA 0Y0KD Cluster_407137 V1271659 S NA 1224P Cluster_315372 V1271660 S Protein of unknown function (Porph_ging) 124PH Cluster_166897 V1271662 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_621857 V1271663 RPLS map03010 J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) COG0335 Cluster_72171 V1271664 G hydrolase family 18 COG3858 Cluster_378915 V1271665 S NA 126HH Cluster_405478 V1271666 ASNA map00250,map00460,map00910,map01100,map01110,map01230 E asparagine synthetase A COG2502 Cluster_117730 V1271667 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_189913 V1271668 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_353781 V1271669 M n-acetylmuramoyl-l-alanine amidase COG5632 Cluster_102810 V1271671 FTSI map00550 M penicillin-binding protein COG0768 Cluster_291345 V1271672 PPNK map00760,map01100 G Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) COG0061 Cluster_2594 V1271673 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_661624 V1271675 TRXA O Thioredoxin COG0526 Cluster_813400 V1271676 RSUA J Pseudouridine synthase COG1187 Cluster_458976 V1271677 RSUA J Pseudouridine synthase COG1187 Cluster_110070 V1271678 S NA 0XRSS Cluster_540308 V1271679 S NA 11FE5 Cluster_18209 V1271680 MUTS2 map03430 L muts2 protein COG1193 Cluster_53520 V1271682 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_458977 V1271683 S NA 0Z9CF Cluster_255243 V1271684 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_166898 V1271685 POTA map02010 E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COG3842 Cluster_307916 V1271686 RPSB map03010 J 30S ribosomal protein S2 COG0052 Cluster_382415 V1271687 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_338189 V1271688 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_309338 V1271689 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_151236 V1271690 S Membrane 0ZQP3 Cluster_81354 V1271692 YGDR E Transporter COG3104 Cluster_228962 V1271693 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_292690 V1271696 YDIA S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) COG1806 Cluster_261711 V1271698 DPPC P ABC transporter permease protein COG1173 Cluster_215032 V1271699 GSIA map02010 E, P ABC transporter COG0444 Cluster_232482 V1271700 E (ABC) transporter COG4608 Cluster_323005 V1271702 FEPC map02010 P ABC, transporter COG1120 Cluster_268444 V1271703 RPOS map05111 K RNA polymerase COG0568 Cluster_103445 V1271705 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_202948 V1271706 map03420,map03430 L helicase COG0210 Cluster_169486 V1271707 M RHS repeat-associated core domain protein COG3209 Cluster_32083 V1271708 M Inherit from COG: YD repeat protein COG3209 Cluster_231306 V1271709 NRDF map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_350628 V1271710 S CAAX amino terminal protease family 0XUJM Cluster_25706 V1271711 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_57281 V1271712 ATPA map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) COG1155 Cluster_158709 V1271713 HOM map00260,map00270,map00300,map01100,map01110,map01120,map01230 E homoserine dehydrogenase COG0460 Cluster_170356 V1271715 YJIM E 2-hydroxyglutaryl-CoA dehydratase COG1775 Cluster_423462 V1271716 S Toxin-antitoxin system, toxin component 0XRRU Cluster_47117 V1271717 CAS3 L CRISPR-associated helicase, cas3 COG1203 Cluster_210511 V1271718 YKGB map00030,map01100,map01110,map01120 G 6-phosphogluconolactonase (EC 3.1.1.31) COG2706 Cluster_224372 V1271719 K Transcriptional regulator (XRE family 11YS4 Cluster_12030 V1271720 CPDA F serine threonine protein phosphatase COG1409 Cluster_352132 V1271722 CLPP map04112 O ATP-dependent Clp protease, proteolytic subunit COG0740 Cluster_552087 V1271723 ACD map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I acyl-CoA dehydrogenase COG1960 Cluster_69275 V1271724 BVU_0960 S ragb susd domaiN-containing protein 0YBCD Cluster_305224 V1271725 N Cell surface protein 0XQ7Y Cluster_711815 V1271726 RPLK map03010 J This protein binds directly to 23S ribosomal RNA (By similarity) COG0080 Cluster_449128 V1271727 ATPH map00190,map00195,map01100 C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) COG0712 Cluster_599867 V1271729 RBO C Superoxide reductase COG2033 Cluster_24191 V1271731 M domain protein COG4932 Cluster_51929 V1271732 CNA M domain protein 0ZWTG Cluster_365374 V1271735 S membrAne 120XT Cluster_419808 V1271736 MUG L U mismatch-specific DNA glycosylase COG3663 Cluster_797229 V1271737 GLK map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G glucokinase COG1940 Cluster_456995 V1271738 MANY map00051,map00520,map01100,map02060 G PTS System COG3715 Cluster_209429 V1271740 T Histidine kinase 0XNMH Cluster_226662 V1271741 SAGG map02010 V ABC transporter, ATP-binding protein COG1131 Cluster_211640 V1271742 map02010 S ABC-2 type transporter 11H02 Cluster_813401 V1271744 YAAK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) COG0718 Cluster_56254 V1271745 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_520585 V1271746 ZURR K Ferric uptake regulator, Fur family COG0735 Cluster_365375 V1271747 CIAR map02020 T response regulator COG0745 Cluster_329135 V1271748 S alpha/beta hydrolase fold 0XV6J Cluster_74826 V1271749 V ABC transporter COG1132 Cluster_197930 V1271751 S Nucleotidyl transferase of unknown function (DUF1814) 0ZWCV Cluster_239914 V1271752 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate (By similarity) COG0167 Cluster_252787 V1271753 CPSY K Transcriptional regulator COG0583 Cluster_485128 V1271754 G, M Nad-dependent epimerase dehydratase COG0702 Cluster_510042 V1271755 map00362,map01100,map01120 S domain protein COG1917 Cluster_37954 V1271756 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_34205 V1271757 S metallophosphoesterase 0XQXV Cluster_3501 V1271758 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_139019 V1271759 PROA map00330,map01100,map01230 E Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) COG0014 Cluster_303711 V1271760 PROC map00330,map01100,map01110,map01230 E pyrroline-5-carboxylate reductase COG0345 Cluster_755211 V1271761 map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_114234 V1271762 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_291346 V1271763 S PHP domain protein COG0613 Cluster_164512 V1271764 ASPB map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aminotransferase COG0436 Cluster_7214 V1271765 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_154478 V1271766 CTPE P Cation-transporting atpase COG0474 Cluster_327649 V1271767 YABB map00340,map00350,map00624,map01120 L Methyltransferase COG4123 Cluster_31301 V1271768 YVFO G arabinogalactan endo-1,4-beta-galactosidase COG3867 Cluster_715182 V1271769 YABB map00340,map00350,map00624,map01120 L Methyltransferase COG4123 Cluster_183007 V1271770 CAPA M Capsule synthesis protein COG2843 Cluster_373648 V1271771 DEOC map00030 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) COG0274 Cluster_65997 V1271772 S NA 0XWEM Cluster_117731 V1271774 S NA 0XWFB Cluster_362066 V1271775 YADS S Membrane COG2860 Cluster_507445 V1271776 S prophage antirepressor 17798@proNOG Cluster_180359 V1271777 FTSW map04112 D cell division protein COG0772 Cluster_123472 V1271778 MURD map00471,map00550,map01100 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COG0771 Cluster_179525 V1271779 RPOD map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_137499 V1271780 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_363634 V1271781 RLUC J pseudouridine synthase COG0564 Cluster_34782 V1271782 O Peptidyl-prolyl cis-trans isomerase 0XT59 Cluster_124766 V1271784 CCA map03013,map03018 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate COG0617 Cluster_122850 V1271785 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_678963 V1271786 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_15044 V1271787 HSDR V Type I Restriction COG0610 Cluster_419809 V1271788 HSDS V type I restriction-modification system COG0732 Cluster_268445 V1271789 HSDS V Restriction modification system DNA (Specificity COG0732 Cluster_216173 V1271790 ERYC E DegT DnrJ EryC1 StrS COG0399 Cluster_169487 V1271791 RFBB map00521,map00523,map01055,map01100,map01110 M dtdp-glucose 4,6-dehydratase COG1088 Cluster_725084 V1271792 S Phosphodiesterase, mj0936 family 11FUN Cluster_70550 V1271793 map02010 V ABC transporter COG1132 Cluster_62096 V1271794 V ABC transporter COG1132 Cluster_414443 V1271795 S Hypothetical bacterial integral membrane protein (Trep_Strep) 0ZQMU Cluster_378916 V1271796 P ABC superfamily ATP binding cassette transporter permease protein 0XT24 Cluster_217365 V1271797 S DNA-binding protein COG3943 Cluster_348994 V1271798 POTA map02010 E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COG3842 Cluster_285983 V1271799 POTB map02010 P ABC transporter, permease COG1176 Cluster_307917 V1271800 POTC map02010 P putrescine abc transporter COG1177 Cluster_499222 V1027005 E subfamily IB COG0560 Cluster_682196 V1027006 S NA 17VSX@proNOG Cluster_799950 V1027007 S Protein of unknown function (DUF2933) 17JEC@proNOG Cluster_499223 V1027008 CSN1 V CRISPR-associated 10TRZ Cluster_772753 V1027010 CAS3 L CRISPR-associated helicase, cas3 COG1203 Cluster_714270 V1027014 BMUL_4952 K addiction module antidote protein COG3636 Cluster_776564 V1027015 COBN map00860,map01100 H cobaltochelatase, cobn subunit COG1429 Cluster_533779 V1027022 G transporter 0XP7I Cluster_585234 V1027024 PERMEASE S permease COG0701 Cluster_628208 V1027027 SUFB O FeS assembly protein SUFB COG0719 Cluster_499225 V1027033 CYOB map00190,map00910,map01100 C Cytochrome C oxidase, subunit I COG0843 Cluster_499226 V1027034 M glycosyl transferase group 1 COG0438 Cluster_499227 V1027035 CAT1 map00281,map00620,map00626,map01110,map01120 C Transferase COG0427 Cluster_499229 V1027040 DUSA J Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_499230 V1027041 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_501753 V1027042 BMUL_5259 S dnaJ domain-containing protein 17D3D@proNOG Cluster_761372 V1027043 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_499231 V1027044 BETA map00260,map01100 E Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) COG2303 Cluster_501754 V1027046 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin 0XQTW Cluster_588499 V1027047 TRAM S conjugative transposon 0YI63 Cluster_686578 V1027048 ARSR K Transcriptional regulator, arsr family COG0640 Cluster_867085 V1027049 T Protein tyrosine phosphatase COG0394 Cluster_727391 V1027050 VEG S Veg protein COG4466 Cluster_776566 V1027051 CYSN map00230,map00450,map00920,map01100,map01120 P may be the GTPase, regulating ATP sulfurylase activity (By similarity) COG2895 Cluster_499233 V1027055 ACTP P p-type atpase COG2217 Cluster_501755 V1027061 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_501756 V1027062 AHPC O alkyl hydroperoxide reductase subunit C (EC 1.11.1.15) COG0450 Cluster_569270 V1027064 L Phage terminase, large subunit COG1783 Cluster_501757 V1027065 BIOB map00780,map01100 H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) COG0502 Cluster_499234 V1027066 L Transposase 11ZAW Cluster_501758 V1027067 STBA S StbA family 17470@proNOG Cluster_609635 V1027069 BMUL_0074 T Sensor Signal Transduction Histidine Kinase COG0642 Cluster_720807 V1027071 map00230,map00240,map01100,map03020 K DNA-directed RNA polymerase, omega subunit 11VZB Cluster_499237 V1027074 YICE F permease COG2233 Cluster_724180 V1027075 K helix-turn-helix domain protein 17P2U@proNOG Cluster_501759 V1027081 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_635933 V1027083 K Phage antirepressor protein KilAC domain COG3645 Cluster_501761 V1027085 LPPL S prolipoprotein LppL 0Z2Q4 Cluster_501762 V1027089 ARND G Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) COG0726 Cluster_501763 V1027090 ADHC map00010,map00561,map00930,map01100,map01110,map01120 C alcohol dehydrogenase COG1064 Cluster_501764 V1027091 P p-type ATPase COG2217 Cluster_588500 V1027092 M glycosyltransferase group 2 family protein 0YW14 Cluster_501765 V1027093 HSDS2 V specificity COG0732 Cluster_501766 V1027095 ASNB map00250,map00910,map01100,map01110,map01120 E asparagine synthetase COG0367 Cluster_501767 V1027097 YFES S Molybdate metabolism regulator COG4884 Cluster_509314 V1027100 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_501768 V1027101 NUSA K Transcription elongation factor NusA COG0195 Cluster_569271 V1027102 BATB S von Willebrand factor, type A COG2304 Cluster_656197 V1027103 GLUC map02010 E ABC transporter COG0765 Cluster_501769 V1027105 map03420,map03430 L helicase COG3973 Cluster_501770 V1027107 CAS3 L CRISPR-associated helicase, cas3 COG1203 Cluster_501771 V1027113 U, W Pfam:YadA COG5295 Cluster_504202 V1027115 LPDG map00010,map00020,map00260,map00280,map00620,map01100,map01110,map01120 C Dihydrolipoamide dehydrogenase COG1249 Cluster_557028 V1027116 YHFA O OsmC family COG1765 Cluster_501772 V1027118 S NA 173XM@proNOG Cluster_501773 V1027119 DCTP C symporter COG1301 Cluster_695168 V1027120 NAGD map00627,map01120 G had-superfamily hydrolase, subfamily iia COG0647 Cluster_635934 V1027121 AFUA map02010 P ABC transporter COG1840 Cluster_677658 V1027123 S Bacterial protein of unknown function (Gcw_chp) 17D6E@proNOG Cluster_740707 V1027126 S Pfam:UPF0153 COG0727 Cluster_691201 V1027127 MQSR S Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation 17J4F@proNOG Cluster_847191 V1027129 RPLC map03010 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 Cluster_504203 V1027130 ABGR K LysR family Transcriptional regulator 16R6E@proNOG Cluster_504204 V1027131 KSE_00140T V type iii restriction protein res subunit 0XRHZ Cluster_769195 V1027133 S Protein of unknown function (DUF2752) 0ZXTM Cluster_652029 V1027135 BMUL_0080 map00230,map04113 F Adenylate cyclase COG1437 Cluster_895437 V1027136 PRMB J Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) COG2890 Cluster_677659 V1027140 K LysR family 17AE4@proNOG Cluster_504206 V1027142 YQIK map04910 S Band 7 protein COG2268 Cluster_831348 V1027143 S Triacylglycerol lipase COG1075 Cluster_730761 V1027144 AZOR I Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) COG1182 Cluster_504207 V1027145 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_504208 V1027147 ORFT M Aminoglycoside phosphotransferase COG3178 Cluster_504209 V1027148 S Membrane 0XQXB Cluster_504210 V1027150 GLTS E Sodium Glutamate Symporter COG0786 Cluster_504211 V1027151 L Resolvase COG1961 Cluster_652030 V1027152 CHEW map02020,map02030 N, T Chemotaxis protein, CheW COG0835 Cluster_504212 V1027153 G Major Facilitator 0XPHU Cluster_581992 V1027154 S NA 17SQU@proNOG Cluster_643918 V1027156 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_539546 V1027157 FADD2 Q Acyl-CoA synthetase COG0318 Cluster_677660 V1027158 LGAS_0609 S Phage minor structural protein GP20 123J7 Cluster_504213 V1027160 TRAN S Conjugal transfer mating pair stabilization protein TraN 17A4V@proNOG Cluster_504214 V1027163 HSDR V type I restriction-modification system COG0610 Cluster_704645 V1027165 S VRR-NUC domain protein 11X78 Cluster_804291 V1027171 map00190,map01100,map02020 C oxidase) subunit II COG1294 Cluster_504215 V1027174 PONA map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_506688 V1027175 S Calcineurin-like phosphoesterase 0YC4X Cluster_504216 V1027178 M Outer membrane protein, OMP85 family 0XNPU Cluster_673161 V1027181 CADR K Transcriptional regulator COG0789 Cluster_506689 V1027182 HSCC O Chaperone COG0443 Cluster_506690 V1027183 RECG map03420,map03440 L transcription-repair coupling factor COG1197 Cluster_643919 V1027189 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III, alpha subunit COG0587 Cluster_504217 V1027190 CCON map00190,map01100,map02020 C cytochrome C oxidase, cbb3-type, subunit i COG3278 Cluster_506691 V1027192 BMUL_0423 K LysR family transcriptional regulator 176ZN@proNOG Cluster_617013 V1027195 HCAR K transcriptional regulator 17AE1@proNOG Cluster_727392 V1027196 BMUL_2277 L DNA Methylase COG1475 Cluster_198926 V1271801 POTD map02010 E ABC transporter COG0687 Cluster_202949 V1271805 COBD map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01230 E decarboxylase COG0079 Cluster_122851 V1271806 COBB map00860,map01100 H Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) COG1797 Cluster_393028 V1271807 COBH map00860,map01100 H Precorrin-8x methylmutase COG2082 Cluster_112780 V1271810 LYSM S Lysm domain protein 12BED Cluster_4162 V1271812 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_40390 V1271813 RECG map03440 L ATP-dependent DNA helicase recg COG1200 Cluster_167707 V1271814 RSEP map04112 M Membrane-associated zinc metalloprotease COG0750 Cluster_285984 V1271816 WECC map00051,map00363,map00520,map00591,map00625,map00650,map01100,map01120 M Dehydrogenase COG0677 Cluster_144994 V1271817 M Glycosyl transferase (Group 1 0XT85 Cluster_117732 V1271819 ICTB M O-Antigen polymerase COG3307 Cluster_260401 V1271820 S Structural protein 11PKS Cluster_502463 V1271821 S NA 0Y5KC Cluster_103446 V1271822 SARE_3718 S Terminase 11NCI Cluster_687973 V1271823 S NA 0XW6Y Cluster_471614 V1271826 OGT L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) COG0350 Cluster_318483 V1271827 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 Cluster_171997 V1271828 TGT J Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COG0343 Cluster_201905 V1271829 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_212730 V1271830 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_67532 V1271831 YIDE P transport protein COG2985 Cluster_232483 V1271835 map00260,map00290,map01100,map01110,map01230 E Threonine dehydratase COG1171 Cluster_156123 V1271836 E Aminotransferase COG0436 Cluster_139020 V1271837 S NA 0XWEM Cluster_131145 V1271838 YQEV J MiaB-like tRNA modifying enzyme COG0621 Cluster_117733 V1271839 NOX map00190 P pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_184717 V1271840 map00520,map00550,map01100 C domain protein 0ZQ9H Cluster_116310 V1271841 VMRA V Mate efflux family protein COG0534 Cluster_398362 V1271842 S Cytidylate kinase 0XP28 Cluster_290027 V1271843 MUTM map03410 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) COG0266 Cluster_520586 V1271844 AACA7 S Catalyzes the transfer of an acetyl group from acetyl- CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring (By similarity) 11UUS Cluster_497258 V1271845 L hydrolase COG0494 Cluster_696131 V1271846 S Inherit from COG: Alpha beta hydrolase COG0596 Cluster_492260 V1271847 S Inherit from COG: Alpha beta hydrolase COG0596 Cluster_193514 V1271849 S NA 0XU0N Cluster_22358 V1271850 PPC map00620,map00680,map00710,map00720,map01100,map01120 C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) COG2352 Cluster_186509 V1271851 RPOD map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_312305 V1271852 YQFO S dinuclear metal center protein, YbgI family COG0327 Cluster_176160 V1271853 SPR M Nlp p60 protein COG0791 Cluster_17976 V1271855 S p-loop domain protein COG4928 Cluster_56512 V1271856 ARGS map00970 J arginyL-tRNA synthetase COG0018 Cluster_151237 V1271859 S Protein of unknown function (DUF819) COG5505 Cluster_489767 V1271860 S domain protein 0XNZW Cluster_260402 V1271861 YHBJ S Displays ATPase and GTPase activities (By similarity) COG1660 Cluster_224373 V1271862 YBHK S UPF0052 protein COG0391 Cluster_251568 V1271863 WHIA K May be required for sporulation (By similarity) COG1481 Cluster_665841 V1271864 S Inherit from COG: leucine Rich Repeat COG4886 Cluster_236129 V1271865 S Inherit from COG: leucine Rich Repeat COG4886 Cluster_345799 V1271866 K M protein trans-acting positive regulator 0Y0QQ Cluster_155310 V1271867 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_178658 V1271868 YCHF J gtp-binding protein COG0012 Cluster_4058 V1271869 YXCA I coA-substrate-specific enzyme activase COG3581 Cluster_447111 V1271870 S Protein of unknown function (DUF2807) 0ZXZV Cluster_130371 V1271871 S YycH protein 12BVJ Cluster_512624 V1271872 S NA 122DU Cluster_473706 V1271873 MRED M Rod shape-determining protein MreD COG2891 Cluster_202950 V1271875 M glycosyltransferase group 2 family protein COG0463 Cluster_162902 V1271876 S Capsular polysaccharide biosynthesis protein 0XUBN Cluster_298230 V1271877 S NA 0YA5G Cluster_128918 V1271878 RARA L recombination factor protein RarA COG2256 Cluster_384183 V1271879 YADS S Membrane COG2860 Cluster_290028 V1271880 YFIO M outer membrane assembly lipoprotein yfio 0ZZRH Cluster_576649 V1271881 S NA 0Y1MD Cluster_323006 V1271882 PPHA T serine threonine protein phosphatase COG0639 Cluster_300893 V1271883 YCLP map02010 P abc transporter atp-binding protein COG4604 Cluster_4141 V1271884 UVRD2 map03420,map03430 L helicase COG0210 Cluster_61561 V1271885 V ABC transporter transmembrane region COG1132 Cluster_268446 V1271886 PEAH map02010 V ABC transporter transmembrane region COG1132 Cluster_288742 V1271887 ISPA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_102811 V1271888 VANW V VanW family COG2720 Cluster_292691 V1271889 S hydrolase COG0561 Cluster_77825 V1271890 P Na Pi-cotransporter COG1283 Cluster_68227 V1271891 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_13779 V1271892 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_60666 V1271893 PGM map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_423463 V1271894 MAF D MAF-like protein COG0424 Cluster_463160 V1271895 LGAS_0605 S phage terminase large subunit 0XSCY Cluster_76104 V1271896 T phage Mu protein F like protein COG5585 Cluster_372026 V1271897 SP_1914 S Cell wall-active antibiotics response protein (DUF2154) 11V5T Cluster_518007 V1271898 K, T lytTr DNA-binding domain protein COG3279 Cluster_49594 V1271899 PURF map00230,map00250,map01100,map01110 F amidophosphoribosyltransferase (EC 2.4.2.14) COG0034 Cluster_711816 V1271900 YSDA S Membrane COG3326 Cluster_80983 V1271901 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_259094 V1271902 S NA 11NX4 Cluster_261712 V1271903 HSDA V restriction COG0732 Cluster_10804 V1271904 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_261713 V1271906 O Band 7 protein COG0330 Cluster_242571 V1271907 FRUK-1 map00051 G 1-phosphofructokinase COG1105 Cluster_751741 V1271908 I Acyltransferase COG0204 Cluster_69276 V1271909 PFK map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G diphosphate--fructose-6-phosphate 1-phosphotransferase COG0205 Cluster_267032 V1271910 PRMA J Methylates ribosomal protein L11 (By similarity) COG2264 Cluster_396623 V1271911 RIBF map00740,map01100 H riboflavin biosynthesis protein ribF COG0196 Cluster_36550 V1271912 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_510043 V1271913 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_62097 V1271914 TOPB L Dna topoisomerase COG0550 Cluster_518008 V1271915 S Helix-turn-helix 11HER Cluster_473707 V1271919 RADC2 L DNA repair protein (RadC COG2003 Cluster_327650 V1271926 S conjugative transposon membrane protein 0XPC1 Cluster_232484 V1271929 U traE protein COG3451 Cluster_81762 V1271930 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_687975 V1271931 V ABC transporter COG1136 Cluster_186510 V1271932 XERS L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) COG0582 Cluster_303712 V1271933 DITI map00061,map00780,map01040,map01100 S KR domain 0XNW1 Cluster_62908 V1271934 S NA 101UU Cluster_31302 V1271935 LKTB3 V ABC transporter, ATP-binding protein COG2274 Cluster_5992 V1271936 BL00969 S NA 0XYM3 Cluster_238648 V1271937 AMET_0853 S NA 17B67@proNOG Cluster_350629 V1271938 VICR map02020 T response regulator COG0745 Cluster_117019 V1271939 VICK map02020 T Histidine kinase 0XNMH Cluster_299497 V1271940 VICX map03013 S domain protein COG1235 Cluster_104014 V1271941 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_42960 V1271944 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_21556 V1271945 G domain protein 11V8D Cluster_279100 V1271946 DEGV S degv family COG1307 Cluster_316897 V1271947 DAPB map00300,map01100,map01110,map01120,map01230 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) COG0289 Cluster_155311 V1271948 CCA map03013,map03018 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate COG0617 Cluster_140534 V1271949 YFMR S ABC transporter, ATP-binding protein COG0488 Cluster_329136 V1271950 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_88586 V1271951 GPMI map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0696 Cluster_132669 V1271952 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_65998 V1271954 YIDE P transport protein COG2985 Cluster_385966 V1271955 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_107068 V1271956 MIAB J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) COG0621 Cluster_549200 V1271957 map00051,map00363,map00591,map00625,map00650,map01100,map01120 S Nadph-dependent fmn reductase COG0431 Cluster_335112 V1271958 YAAA L UPF0246 protein COG3022 Cluster_499922 V1271959 SP_1465 S Domain of unknown function (DUF1836) 123H7 Cluster_232485 V1271960 RBSC S ABC transporter (Permease) COG1079 Cluster_499923 V1271961 map03430 L D12 class N6 adenine-specific DNA methyltransferase COG0338 Cluster_728405 V1271962 map03430 L D12 class N6 adenine-specific DNA methyltransferase COG0338 Cluster_89526 V1271963 S Primase C terminal 1 (PriCT-1) 0YFRN Cluster_31509 V1271964 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_333599 V1271965 COBK map00860,map01100 H precorrin-6x reductase COG2099 Cluster_189047 V1271966 COBT map00860,map01100 H Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) COG2038 Cluster_191689 V1271968 DINB L Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) COG0389 Cluster_61821 V1271969 DING L helicase COG1199 Cluster_146533 V1271970 RODA map04112 D cell division protein COG0772 Cluster_287380 V1271972 YITL S S1 RNA binding domain protein COG2996 Cluster_208391 V1271973 S integral membrane protein COG0392 Cluster_38321 V1271974 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_20848 V1271976 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_108206 V1271978 TILS D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) COG0037 Cluster_156124 V1271979 RLMI S Methyltransferase COG1092 Cluster_385967 V1271980 S 3-5 exonuclease 11J3A Cluster_139802 V1271981 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_155312 V1271982 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_487422 V1271983 S (LipO)protein 0Y5X3 Cluster_718430 V1271984 PURL F phosphoribosylformylglycinamidine synthase COG0047 Cluster_702442 V1271985 HOLA map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii, delta' subunit COG1466 Cluster_171998 V1271986 HEMN map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_55250 V1271987 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_429096 V1271988 S NA 0Y7XN Cluster_333600 V1271989 SUFC O feS assembly ATPase SufC COG0396 Cluster_105205 V1271990 SUFB O FeS assembly protein SUFB COG0719 Cluster_241199 V1271991 SUFB O SufB sufD domain protein COG0719 Cluster_405480 V1271995 CAS3 L CRISPR-Associated Helicase Cas3 COG1203 Cluster_247777 V1271996 S Alpha beta hydrolase COG0596 Cluster_95719 V1271997 S domain protein 0Y8F3 Cluster_469448 V1271998 OXYR K Transcriptional regulator 0XNR2 Cluster_189914 V1271999 S Membrane bound regulatory protein 12CIW Cluster_60398 V1272000 L endonuclease I COG2356 Cluster_147316 V1272001 S NA 0XWFB Cluster_306605 V1272002 YGCG S of methanol dehydrogenase type COG1512 Cluster_341062 V1272005 Q methyltransferase, type 11 COG0500 Cluster_360486 V1272006 ALKA map03410 L 8-oxoguanine DNA glycosylase COG0122 Cluster_215033 V1272007 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_319963 V1272008 S NA 0Z20Q Cluster_241200 V1272009 ASNA map00250,map00460,map00910,map01100,map01110,map01230 E asparagine synthetase A COG2502 Cluster_437049 V1272011 GPO map00480,map00590 O Glutathione peroxidase COG0386 Cluster_102812 V1272012 E solute symporter COG0591 Cluster_711817 V1272013 HUP L DNA-binding protein COG0776 Cluster_362067 V1272015 CP_0141 S metallophosphoesterase COG1768 Cluster_445055 V1272016 map00230 F Adenylate cyclase COG1437 Cluster_38841 V1272017 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_515340 V1272018 OPPCD E, P abc transporter COG1173 Cluster_338190 V1272021 SERB E HAD-superfamily subfamily IB hydrolase COG0560 Cluster_363635 V1272022 SRTA M (sortase) family COG3764 Cluster_239915 V1272023 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_13078 V1272024 M NA 11FBZ Cluster_824976 V1272029 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_287381 V1272030 CLOLE_0797 S NA 11N1T Cluster_48549 V1272031 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_429097 V1272032 CASE L crispr-associated protein 0XPHC Cluster_437050 V1272033 I esterase COG0657 Cluster_47297 V1272034 CAPD map00521,map00523,map01055,map01100,map01110 M Polysaccharide biosynthesis protein COG1086 Cluster_198927 V1272035 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_596371 V1272037 S NA 11KH0 Cluster_38497 V1272038 YGIQ C upf0313 protein COG1032 Cluster_429098 V1272039 SCPB K Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) COG1386 Cluster_504870 V1272040 YKUL S Cbs domain protein COG0517 Cluster_59077 V1272041 V ABC transporter COG1132 Cluster_59597 V1272042 LMRA V ABC transporter transmembrane region COG1132 Cluster_183008 V1272043 map00790,map01100 S 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase 12BSQ Cluster_63471 V1272044 PGM map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_427205 V1272045 MUTY map03410 L a g-specific adenine glycosylase COG1194 Cluster_104015 V1272046 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_102277 V1272047 L transposase 11GFI Cluster_88136 V1272048 S Domain of unknown function (DUF2828) 0ZQDJ Cluster_148108 V1272049 F Uracil permease COG2233 Cluster_618214 V1272050 PHOH T Phoh family COG1702 Cluster_168561 V1272054 NAGA map00520,map01110 G GlcNAc 6-P deacetylase COG1820 Cluster_160412 V1272056 THII map00730,map01100,map04122 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) COG0301 Cluster_423464 V1272057 YGCG S of methanol dehydrogenase type COG1512 Cluster_463161 V1272059 E HAD-superfamily subfamily IB hydrolase COG0560 Cluster_288743 V1272060 POLA_2 L DNA polymerase 0XRUF Cluster_51930 V1272062 S NA 11QUB Cluster_7215 V1272065 S S-layer domain protein 12C8X Cluster_296831 V1272066 PEAH map02010 V ABC transporter, ATP-binding permease protein COG1132 Cluster_90438 V1272067 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_610739 V1272068 K Transcriptional Regulator AraC Family 0ZYR5 Cluster_231307 V1272069 S CAAX amino terminal protease family protein COG1266 Cluster_190766 V1272070 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_429099 V1272071 SP_2191 S isoprenylcysteine carboxyl methyltransferase family protein COG1755 Cluster_119913 V1272072 HK06 T Histidine kinase COG0642 Cluster_377134 V1272073 RR06 T response regulator COG0745 Cluster_17432 V1272074 V type iii restriction 0ZVEY Cluster_29191 V1272075 GBS0396 map03070 U Pfam:TraG COG3505 Cluster_801206 V1272076 S NA 0YP3E Cluster_26678 V1272077 PGN_0946 S Membrane COG1033 Cluster_306606 V1272080 BA_5646 S hydrolase COG0561 Cluster_396624 V1272081 UDP map00240,map00983,map01100 F Uridine phosphorylase COG2820 Cluster_207260 V1272082 DCMB map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_196175 V1272083 LCMA map00270,map01100 L C-5 cytosine-specific DNA methylase COG0270 Cluster_425266 V1272084 MUTL2 S dna mismatch repair 16SHP@proNOG Cluster_433080 V1272085 map02010 P ABC superfamily ATP binding cassette transporter COG1122 Cluster_98448 V1272086 M Inherit from COG: YD repeat protein COG3209 Cluster_711818 V1272088 S Transglycosylase-associated protein 125P9 Cluster_50579 V1272089 PPK map00190,map03018 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) COG0855 Cluster_22205 V1272090 M exopolysaccharide biosynthesis COG0489 Cluster_718431 V1272091 MANX map00051,map00520,map01100,map02060 G PTS System COG3444 Cluster_89068 V1272092 VIRE2 S Virulence-associated protein e COG5545 Cluster_217366 V1272093 S NA 0XTEF Cluster_276443 V1272094 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0470 Cluster_330549 V1272095 YJFP S Esterase COG1073 Cluster_31086 V1272096 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG4199 Cluster_305226 V1272097 PHAB map00360,map01120 I enoyl-CoA hydratase COG1024 Cluster_41388 V1272098 L Recombinase COG1961 Cluster_277750 V1272100 L Primosomal protein, DnaI COG1484 Cluster_583014 V1272101 S NA 102J1 Cluster_251569 V1272102 FABK map00061,map01100 I 2-Nitropropane dioxygenase COG2070 Cluster_531832 V1272103 S NA 125RT Cluster_117734 V1272104 RUMA map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_670143 V1272105 SPOVG M Could be involved in septation (By similarity) COG2088 Cluster_166899 V1272106 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_128919 V1272107 PBUX F permease COG2233 Cluster_549201 V1272108 CRCB D Protein CrcB homolog COG0239 Cluster_10726 V1272110 HSDR V Type I Restriction COG0610 Cluster_504871 V1272111 FEMX map00550,map01100 V Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor (By similarity) COG2348 Cluster_18677 V1272112 PPDK map00620,map00680,map00710,map00720,map01100,map01120 G Pyruvate phosphate dikinase COG0574 Cluster_318484 V1272113 LIVG map02010 E ABC transporter COG0411 Cluster_563925 V1272114 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_21005 V1272115 PEPN map00480,map01100 E Aminopeptidase COG0308 Cluster_6467 V1272117 S NA 101UU Cluster_362068 V1272118 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_27469 V1272119 V FtsX-like permease family 0ZW5X Cluster_28071 V1272121 M YD repeat protein COG3209 Cluster_196989 V1272122 CELB map02060 G pts system 124SH Cluster_271099 V1272123 THRB map00260,map01100,map01120,map01230 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) COG0083 Cluster_131146 V1272124 HOM map00260,map00270,map00300,map01100,map01110,map01120,map01230 E homoserine dehydrogenase COG0460 Cluster_80171 V1272125 PRIA map03440 L Primosomal protein n' COG1198 Cluster_251570 V1272126 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_563926 V1272127 YUGP S zinc metallopeptidase COG2738 Cluster_303713 V1272128 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_192621 V1272129 RPSA map00900,map01100,map01110,map03010 J Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) COG0761 Cluster_125427 V1272130 MIAB J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) COG0621 Cluster_126817 V1272131 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_373649 V1272132 S Metal Dependent Phosphohydrolase COG1418 Cluster_246528 V1272133 PYRB map00240,map00250,map01100 F aspartate transcarbamylase COG0540 Cluster_770188 V1272134 RPOD map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_499924 V1272135 map00020,map00300,map00630,map00720,map01100,map01110,map01120,map01210,map01230 C aconitate hydratase COG1048 Cluster_145740 V1272136 ICD map00020,map00480,map00720,map01100,map01110,map01120,map01210,map01230,map04146 C isocitrate dehydrogenase (NADP) COG0538 Cluster_309339 V1272137 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_526231 V1272138 S Putative membrane peptidase family (DUF2324) 11XS0 Cluster_563927 V1272139 S NUDIX hydrolase 0XW7W Cluster_26785 V1272140 UVRD map03420,map03430 L ATP-dependent DNA helicase pcra COG0210 Cluster_458978 V1272148 E amino acid COG0531 Cluster_318485 V1272149 JAG S Single-stranded nucleic acid binding R3H domain-containing protein COG1847 Cluster_599868 V1272150 S corrinoid protein 11G0X Cluster_203999 V1272151 HUTG map00330,map00340,map01100 E formiminoglutamate hydrolase COG0010 Cluster_515341 V1272153 BMUL_1547 K Transcriptional regulator 0XUB6 Cluster_309340 V1272154 MRP D ATP-binding protein COG0489 Cluster_20765 V1272155 S NA 0XSI9 Cluster_338191 V1272156 S Protein of unknown function (Porph_ging) 124PH Cluster_15903 V1272157 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_414444 V1272158 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_518009 V1272159 S Zinc ribbon domain protein 120YB Cluster_232486 V1272160 CAS1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) COG1518 Cluster_194446 V1272161 CAS2 L CRISPR-associated protein cas2 11VHR Cluster_20156 V1272162 S Membrane COG4485 Cluster_296832 V1272163 YBIT S ABC transporter, ATP-binding protein COG0488 Cluster_225542 V1272165 OPPF map02010 E (ABC) transporter COG4608 Cluster_199923 V1272166 OPPD map02010 E, P ABC transporter COG0444 Cluster_10517 V1272168 G Bacterial group 2 Ig-like protein COG5492 Cluster_80172 V1272169 M Inherit from COG: YD repeat protein COG3209 Cluster_341063 V1272170 M RHS repeat-associated core domain protein COG3209 Cluster_586209 V1272171 FTSW map04112 D cell division protein COG0772 Cluster_281751 V1272172 S Membrane COG2035 Cluster_384185 V1272173 GPMB map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_225543 V1272177 PLSX map00561,map00564,map01100 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) COG0416 Cluster_72172 V1272178 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_120635 V1272179 MSRR K TRANSCRIPTIONal COG1316 Cluster_137500 V1272181 APEB E M18 family aminopeptidase COG1362 Cluster_264387 V1272183 S YitT family COG1284 Cluster_64026 V1272184 LMRA map02010 V abc transporter COG1132 Cluster_110761 V1272185 YFIC map02010 V ABC transporter COG1132 Cluster_342585 V1272186 CSE4 L Crispr-associated protein, cse4 family 0Y6PV Cluster_347394 V1272187 CAS5E L crispr-associated protein 11JEJ Cluster_372027 V1272188 CASE L crispr-associated protein 0XPHC Cluster_89527 V1272190 S NA 11J02 Cluster_540309 V1272191 YIDE P transport protein COG2985 Cluster_307918 V1272192 COBQ S Glutamine amidotransferase COG3442 Cluster_275113 V1272193 YBBP S TIGR00159 family COG1624 Cluster_7151 V1272194 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_191690 V1272195 C pyridine nucleotide-disulfide oxidoreductase family protein COG1252 Cluster_117735 V1272196 F permease COG2233 Cluster_793260 V1272197 CLOSA_1745 L transposase COG2963 Cluster_200920 V1272198 S NA 0ZS65 Cluster_362069 V1272199 YLME F alanine racemase domain protein COG0325 Cluster_144245 V1272201 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_560953 V1272202 S Membrane COG3619 Cluster_678965 V1272203 S Membrane COG3619 Cluster_393030 V1272204 RPLC map03010 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 Cluster_396625 V1272205 RPLD map03010 J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) COG0088 Cluster_699403 V1272206 RPLW map03010 J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) COG0089 Cluster_287382 V1272207 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_708621 V1272208 RPSS map03010 J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) COG0185 Cluster_762521 V1272209 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_333601 V1272210 S NA 0Y843 Cluster_323007 V1272211 I CoA-substrate-specific enzyme activase COG1924 Cluster_77826 V1272213 CSN1 L CRISPR-associated protein, Csn1 family COG3513 Cluster_242572 V1272214 CAS1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) COG1518 Cluster_504872 V1272217 L Inherit from COG: transposase COG1943 Cluster_100576 V1272218 K Inherit from firmNOG: Transcriptional regulator COG2865 Cluster_185590 V1272219 P permease COG0628 Cluster_23976 V1272220 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_478071 V1272221 RUVC map03440 L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) COG0817 Cluster_419810 V1272222 RUVA map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) COG0632 Cluster_257765 V1272223 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_142017 V1272224 RIBF map00740,map01100 H riboflavin biosynthesis protein ribF COG0196 Cluster_57775 V1272227 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_499925 V1272228 S NA 1837C@proNOG Cluster_135093 V1272229 YNBB map00260,map00270,map00450,map01100,map01230 P aluminum resistance protein COG4100 Cluster_108207 V1272230 MUTL map03430 L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) COG0323 Cluster_287383 V1272231 S SusD family 0YJ1G Cluster_367070 V1272232 ADCC map02010 P ABC transporter COG1121 Cluster_303714 V1272233 map02010 P abc-3 protein COG1108 Cluster_318486 V1272234 SP_1071 S abc transporter atp-binding protein COG1101 Cluster_543234 V1272235 BMUL_0473 S ABC transporter, permease COG4120 Cluster_292692 V1272236 S repeat protein 0XV4V Cluster_528998 V1272238 RPLO map03010 J Binds to the 23S rRNA (By similarity) COG0200 Cluster_449129 V1272239 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_443064 V1272240 RPLE map03010 J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COG0094 Cluster_645114 V1272241 RPLX map03010 J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) COG0198 Cluster_257766 V1272243 S tetratricopeptide 0XQVJ Cluster_288744 V1272244 map00230,map00240,map00760,map01100,map01110 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) COG0005 Cluster_199924 V1272245 MTNA map00270,map01100 J Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) COG0182 Cluster_7032 V1272246 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_183009 V1272251 M Inherit from COG: domain protein COG4932 Cluster_447112 V1272253 ZURM map02010,map02020 P ABC, transporter COG1108 Cluster_401868 V1272255 YQGX map00620 Q domain protein COG0491 Cluster_34917 V1272256 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_12497 V1272259 N repeat protein 11QCF Cluster_56255 V1272260 S NA 11RZ5 Cluster_58284 V1272261 map02010 E ABC, transporter COG4166 Cluster_828772 V1272262 SP_0182 V Peptidase U61, LD-carboxypeptidase A COG1619 Cluster_105819 V1272263 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_122177 V1272265 S NA 0Z9TI Cluster_549202 V1272268 RBPA S Rna-binding protein COG0724 Cluster_37179 V1272270 S NA 0XW3C Cluster_279101 V1272271 S NA 0YFTJ Cluster_149604 V1272275 PEPS E aminopeptidase COG2309 Cluster_384186 V1272276 S NA 11N5Z Cluster_95220 V1272277 TRAA map03440 L mobA MobL family protein COG0507 Cluster_657429 V1272278 S NA 11NGD Cluster_142793 V1272280 S plasmid recombination enzyme 0XPM6 Cluster_61822 V1272281 S TPR-repeat-containing protein 0ZKX3 Cluster_614463 V1272282 VIRE2 S Virulence-associated protein e COG5545 Cluster_7731 V1272283 S NA 0YH2T Cluster_190767 V1272284 S NA 0Y8RQ Cluster_206166 V1272286 HOLA map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii, delta' subunit COG1466 Cluster_633189 V1272287 RPSO map03010 J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) COG0184 Cluster_279102 V1272288 BL02377 S S-adenosyl-l-methionine hydroxide adenosyltransferase COG1912 Cluster_443066 V1272289 SP_0482 S UPF0397 protein COG4720 Cluster_579776 V1272290 S Conserved Protein COG3543 Cluster_117020 V1272291 S Radical SAM superfamily COG0641 Cluster_848250 V1272293 YAJC map03060,map03070 U Preprotein translocase YajC subunit COG1862 Cluster_507447 V1272296 CLOSA_1745 L transposase COG2963 Cluster_10424 V1272297 DPNA L helicase COG4646 Cluster_101159 V1272298 PEPA map00480,map01100 E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) COG0260 Cluster_247778 V1272299 YDED E, G Membrane COG0697 Cluster_734923 V1272300 S Cytidylate kinase 0XP28 Cluster_116311 V1272301 AGCS E amino acid carrier protein COG1115 Cluster_100028 V1272302 AGCS E amino acid carrier protein COG1115 Cluster_382416 V1272303 map00670,map01100 E Methenyltetrahydrofolate cyclohydrolase COG3404 Cluster_82553 V1272304 CMK map00240,map00410,map00770,map01100,map01110 F Cytidine monophosphate kinase COG0283 Cluster_20549 V1272305 S Inherit from COG: domain protein COG1511 Cluster_318487 V1272306 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_531833 V1272307 RSEP map04112 M Membrane-associated zinc metalloprotease COG0750 Cluster_120636 V1272308 NORM V Mate efflux family protein COG0534 Cluster_649215 V1272309 S Membrane Fusion Protein 0ZZS9 Cluster_212731 V1272310 GPSA map00564 C NADPH-dependent glycerol-3-phosphate dehydrogenase COG0240 Cluster_24473 V1272312 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_138264 V1272313 MURE map00300,map00550,map01100 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_447114 V1272314 FAT map00061,map01100 I Acyl-ACP thioesterase COG3884 Cluster_108819 V1272315 INT L Resolvase COG1961 Cluster_738258 V1272316 S NA 0ZD0J Cluster_121412 V1272317 L Integrase 0YTFQ Cluster_173737 V1272318 V Type I restriction modification DNA specificity domain COG0732 Cluster_21144 V1272319 S NA 0YH7P Cluster_97899 V1272320 map02010 G Inherit from COG: extracellular solute-binding protein, family 1 COG2182 Cluster_126818 V1272321 map02010 P permease protein COG1175 Cluster_142018 V1272323 WANG_1265 L transposase IS605 OrfB family 0XT7Q Cluster_53057 V1272325 L Recombinase COG1961 Cluster_817140 V1272326 S NA 0Y5YJ Cluster_427207 V1272327 LSA S (ABC) transporter COG0488 Cluster_463163 V1272328 map00020,map00300,map00630,map00720,map01100,map01110,map01120,map01210,map01230 C aconitate hydratase COG1048 Cluster_357166 V1272329 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_180360 V1272330 GCVT map00260,map00670,map00910,map01100 E The glycine cleavage system catalyzes the degradation of glycine (By similarity) COG0404 Cluster_121413 V1272331 GCVPA map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG0403 Cluster_26896 V1272332 S NA 0XW3C Cluster_310775 V1272333 YLQF K Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) COG1161 Cluster_288745 V1272334 SP_1245 S hydrolase COG0561 Cluster_377135 V1272336 T response regulator COG0745 Cluster_323008 V1272341 S Membrane 125GN Cluster_174556 V1272342 HEMN map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_233744 V1272343 HFLC O SPFH domain, Band 7 family protein COG0330 Cluster_57282 V1272344 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_357167 V1272345 YGDL H uba thif-type nad fad binding protein COG1179 Cluster_537512 V1272346 T Positive regulator of 0XUF3 Cluster_458979 V1272347 L NUDIX hydrolase COG0494 Cluster_9673 V1272348 S s-layer domain-containing protein 11ZJU Cluster_46147 V1272349 S NA 11VK0 Cluster_817141 V1272350 map02010 P ABC transporter COG1122 Cluster_315373 V1272351 COAX map00770,map01100 K Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) COG1521 Cluster_463164 V1272353 SPEG map00330,map01100 J acetyltransferase, (GNAT) family COG1670 Cluster_510044 V1272354 RLMH S Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) COG1576 Cluster_292693 V1272355 S YycH protein 0ZZRJ Cluster_618215 V1272356 S NA 11QW9 Cluster_268447 V1272357 GLTA map00250,map00910,map01100,map01110,map01120,map01230 E Glutamate synthase COG0543 Cluster_239916 V1272358 NRNA J phosphoesterase RecJ domain protein COG0618 Cluster_520587 V1272359 FLD C Flavodoxin COG0716 Cluster_391221 V1272361 YRRM map00340,map00350,map00360,map00624,map00940,map00941,map00945,map01100,map01110,map01120 S O-methyltransferase COG4122 Cluster_292694 V1272362 PPNK map00760,map01100 G Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) COG0061 Cluster_224374 V1272363 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_81763 V1272364 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_138265 V1272365 PPSA map00620,map00680,map00720,map01100,map01120 G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) COG0574 Cluster_378917 V1272366 K Transcriptional regulator, TetR family 11G12 Cluster_138266 V1272367 L recombinase COG1961 Cluster_385968 V1272369 NTH map03410 L endonuclease III COG0177 Cluster_105206 V1272370 VANW V VanW family COG2720 Cluster_327652 V1272371 YQJA S Membrane COG4129 Cluster_148846 V1272373 E amidohydrolase COG1473 Cluster_162903 V1272374 P Sodium/hydrogen exchanger family COG0025 Cluster_91879 V1272377 GALT map00052,map00520,map01100,map01110 G UDP-glucose-hexose-1-phosphate uridylyltransferase COG4468 Cluster_161229 V1272378 GALK map00052,map00520,map01100,map01110 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) COG0153 Cluster_494751 V1272379 YJJH S Phosphohydrolase COG1409 Cluster_51333 V1272380 MUTL map03430 L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) COG0323 Cluster_196990 V1272381 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_154479 V1272385 S gCN5-related N-acetyltransferase 11FK1 Cluster_150473 V1272386 P Sodium hydrogen exchanger 0XRVN Cluster_633190 V1272387 S NA 1259M Cluster_173738 V1272389 INT L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) COG0582 Cluster_71836 V1272391 D domain protein 0XTIC Cluster_188203 V1272393 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_226663 V1272394 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_368693 V1272395 S NA 0XXAQ Cluster_191691 V1272400 POTD map02010 E ABC transporter COG0687 Cluster_405481 V1272402 SPOU J rrna methyltransferase COG0566 Cluster_246529 V1272403 S beta-propeller domains of methanol dehydrogenase type COG1512 Cluster_9879 V1272404 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_284531 V1272405 S NA 0YIZN Cluster_92831 V1272406 TEH_04440 map00052,map01100,map02060 G PTS system, galactitol-specific IIc component COG3775 Cluster_157843 V1272408 L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) COG0582 Cluster_145741 V1272410 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_184718 V1272411 DPRA L DNA protecting protein DprA COG0758 Cluster_433081 V1272412 COMM O Mg chelatase subunit ChlI COG0606 Cluster_11793 V1272413 ADDA L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation COG1074 Cluster_191692 V1272414 C Alcohol dehydrogenase zinc-binding domain protein COG1063 Cluster_492261 V1272416 S NA 0YFX8 Cluster_324590 V1272417 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_718432 V1272419 SP_0276 S addiction module toxin, RelE StbE family COG3041 Cluster_57030 V1272420 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_177816 V1272423 NLPD M peptidase M23 COG0739 Cluster_344187 V1272424 FTSE map02010 D Cell division ATP-binding protein ftsE COG2884 Cluster_429101 V1272425 S Rib/alpha-like repeat 10008 Cluster_355461 V1272430 S atp gtp-binding protein 11QV4 Cluster_193515 V1272431 VORB map00020,map00280,map00720,map01100,map01120 C Pyruvate flavodoxin ferredoxin oxidoreductase domain protein COG0674 Cluster_135094 V1272434 V HNH endonuclease COG1403 Cluster_125428 V1272437 S NA 0XPEA Cluster_127514 V1272438 GSHA map00480,map01100 H glutamate--cysteine ligase COG3572 Cluster_237326 V1272439 BMUL_5818 C Iron-sulfur cluster binding protein COG1139 Cluster_225544 V1272440 ANSA map00250,map00460,map00910,map01100,map01110 E l-asparaginase (EC 3.5.1.1) COG0252 Cluster_264388 V1272441 L DNA polymerase COG3359 Cluster_407139 V1272444 PVAA M pneumococcal vaccine antigen COG0741 Cluster_225545 V1272445 S NA 11WEQ Cluster_179526 V1272446 TGT J Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COG0343 Cluster_708623 V1272447 LKTB3 V ABC transporter, ATP-binding protein COG2274 Cluster_90439 V1272448 S oligopeptide-binding protein OppA 10ER5 Cluster_275114 V1272449 METQ map02010 P lipoprotein COG1464 Cluster_315374 V1272450 S NA 11SYG Cluster_809405 V1272452 S Hydrid cluster protein-associated redox disulfide domain protein 123UM Cluster_307919 V1272454 S Phospholipase, patatin family 0YEF4 Cluster_250345 V1272455 S NA 11TYD Cluster_272429 V1272456 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_785474 V1272457 S NA 0ZHU9 Cluster_358816 V1272460 L C-5 cytosine-specific DNA methylase COG0270 Cluster_412577 V1272461 OCAR_6158 L Terminase, large subunit COG4626 Cluster_389494 V1272462 S copper amine 121X1 Cluster_245187 V1272463 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG0582 Cluster_116312 V1272464 RNY S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 Cluster_683540 V1272467 RPOZ map00230,map00240,map01100,map03020 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) COG1758 Cluster_255244 V1272468 XYLG S ABC transporter COG3845 Cluster_170357 V1272469 RBSC-1 S ABC transporter (Permease COG4603 Cluster_237327 V1272470 S copper amine 121X1 Cluster_124115 V1272471 CCA map03013,map03018 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate COG0617 Cluster_828774 V1272472 S NA 125IJ Cluster_370399 V1272473 PHOB map02020 T regulator COG0745 Cluster_375359 V1272474 PHOU P Plays a role in the regulation of phosphate uptake COG0704 Cluster_316898 V1272475 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_368694 V1272476 PSTA map02010 P phosphate abc transporter COG0581 Cluster_552088 V1272477 S Uncharacterised protein family (UPF0150) 0ZXU8 Cluster_711819 V1272478 S NA 11SFV Cluster_291347 V1272481 S NA 11PBC Cluster_49971 V1272482 SELB map00450,map00970 J Selenocysteine-specific translation elongation factor COG3276 Cluster_28158 V1272483 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_504874 V1272486 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG2812 Cluster_52597 V1272487 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_242573 V1272488 S NA 0Y8K6 Cluster_637243 V1272490 RNZ map03013 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) COG1234 Cluster_144995 V1272491 HFLX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COG2262 Cluster_12459 V1272492 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_143484 V1272493 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_139803 V1272494 O Erythromycin esterase COG2312 Cluster_296833 V1272495 S NA 11U6M Cluster_64293 V1272496 NIST map02010 V ABC transporter 0XPIZ Cluster_309341 V1272497 MODA map02010 P ABC transporter, periplasmic molybdate-binding protein COG0725 Cluster_53787 V1272499 V ATPase associated with various cellular activities aaa_5 COG1401 Cluster_451112 V1272501 HSDS V restriction COG0732 Cluster_34206 V1272502 S domain protein 12C1H Cluster_421614 V1272503 S s-layer domain-containing protein 11ZJU Cluster_143485 V1272504 V Mate efflux family protein COG0534 Cluster_375360 V1272507 ENGB S Necessary for normal cell division and for the maintenance of normal septation (By similarity) COG0218 Cluster_482804 V1272508 APBE H Thiamine biosynthesis COG1477 Cluster_189915 V1272509 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_494752 V1272510 NRDR K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) COG1327 Cluster_502464 V1272511 TRML map04122 J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) COG0219 Cluster_239917 V1272513 DGT map00230 F deoxyguanosinetriphosphate triphosphohydrolase-like protein COG0232 Cluster_813403 V1272515 S Phage protein Gp19 Gp15 Gp42 126N3 Cluster_589499 V1272516 S NA 0YX6X Cluster_368695 V1272517 S NA COG5412 Cluster_447115 V1272518 HXLB map00030,map00040,map00680,map01100,map01120,map01230 G 6-phospho 3-hexuloisomerase COG0794 Cluster_512625 V1272519 map00052,map01100,map02060 G PTS System COG1762 Cluster_518010 V1272520 NHAA map00680 P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) COG3004 Cluster_82554 V1272521 PRFC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) COG4108 Cluster_546167 V1272522 K DNA-binding helix-turn-helix protein 11KHV Cluster_189916 V1272523 ASD map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) COG0136 Cluster_59894 V1272524 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_683541 V1272527 map00350,map00362,map00627,map00642,map00903,map01120 K acetyltransferase COG0454 Cluster_156980 V1272528 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_124767 V1272529 GLDE P gliding motility-associated protein GldE COG1253 Cluster_728408 V1272530 map00770 S 4'-phosphopantetheinyl transferase 0XPB1 Cluster_257767 V1272531 FLUTA_0256 L Transposase COG3464 Cluster_142794 V1272533 PEPS E aminopeptidase COG2309 Cluster_355462 V1272535 MTNN map00270,map01100 F Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) COG0775 Cluster_83017 V1272536 YFMM S ABC transporter, ATP-binding protein COG0488 Cluster_99507 V1272537 AMYA map00500,map01100,map04973 G Alpha-amylase COG0366 Cluster_805372 V1272538 S DNA alkylation repair enzyme 11MSB Cluster_394844 V1272539 AHPC O alkyl hydroperoxide reductase COG0450 Cluster_303715 V1272540 S TIM-barrel fold 11FGY Cluster_133504 V1272542 AROA map00400,map00401,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate synthase COG0128 Cluster_55004 V1272543 U TraG family COG3505 Cluster_163721 V1272544 T serine threonine protein kinase COG0515 Cluster_437051 V1272546 ATPE map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) 0ZX7S Cluster_143486 V1272547 S fad dependent oxidoreductase COG2509 Cluster_13586 V1272548 CSN1 L CRISPR-associated protein, Csn1 family COG3513 Cluster_192622 V1272549 M RHS repeat-associated core domain protein COG3209 Cluster_281752 V1272550 TIG O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COG0544 Cluster_141291 V1272551 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_394845 V1272552 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_149605 V1272553 HFLX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COG2262 Cluster_718434 V1272554 PPIB O PPIases accelerate the folding of proteins COG0652 Cluster_451113 V1272555 S NA 1161C Cluster_563928 V1272556 RPSK map03010 J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) COG0100 Cluster_610740 V1272557 RPSM map03010 J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits COG0099 Cluster_384187 V1272558 ADK map00230,map00240,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_69942 V1272559 V ABC, transporter COG1132 Cluster_200921 V1272561 P Binding-protein-dependent transport systems, inner membrane component COG0600 Cluster_302269 V1272562 NASD map00910,map02010 P (ABC) transporter COG1116 Cluster_194447 V1272565 S NA 0XP5S Cluster_114904 V1272566 ALGI M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_725087 V1272567 S ABC transporter COG0488 Cluster_13864 V1272568 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_54042 V1272572 TYPA T gtp-binding protein typa COG1217 Cluster_859886 V1272573 RUBR C rubredoxin COG1773 Cluster_128920 V1272575 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_352133 V1272576 S NA 0ZVJP Cluster_387776 V1272577 SP_1646 map00620 S metallo-beta-lactamase superfamily protein COG0491 Cluster_128206 V1272579 YEGQ map05120 O peptidase, U32 COG0826 Cluster_242574 V1272580 PYRB map00240,map00250,map01100 F aspartate transcarbamylase COG0540 Cluster_107069 V1272581 S radical SAM domain protein COG0535 Cluster_79488 V1272582 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_408913 V1272583 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_423466 V1272584 M Transglycosylase COG0741 Cluster_80592 V1272585 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_277751 V1272586 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_56513 V1272587 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_119914 V1272589 VIRE L Virulence-associated protein e COG5545 Cluster_32443 V1272590 S Inherit from NOG: LPXTG-motif cell wall anchor domain protein 0YEBJ Cluster_79489 V1272591 LPDA map00010,map00020,map00260,map00280,map00620,map01100,map01110,map01120 C dihydrolipoyl dehydrogenase COG1249 Cluster_219654 V1272592 LPLA map00785,map01100 H Lipoate-protein, ligase COG0095 Cluster_437052 V1272593 HEMN map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_55251 V1272594 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_129626 V1272596 YIEG S Xanthine uracil vitamin C permease COG2252 Cluster_252788 V1272597 YICC map03010 S YicC domain protein COG1561 Cluster_416222 V1272598 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG0194 Cluster_487423 V1272599 ORN map03008 A 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) COG1949 Cluster_95720 V1272600 PGCA map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_83018 V1272602 GRDC C reductase complex component C 0XQ4S Cluster_766471 V1272603 S selenoprotein B, glycine betaine sarcosine D-proline reductase 123JW Cluster_298231 V1272604 PHBA map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map02020 I Acetyl-CoA acetyltransferase COG0183 Cluster_499927 V1272605 H Molybdenum cofactor synthesis domain protein COG0303 Cluster_339612 V1272606 S Multi-copper polyphenol oxidoreductase laccase COG1496 Cluster_181178 V1272607 S repeat protein 11IAG Cluster_276444 V1272608 YPFJ S zinc metallopeptidase COG2321 Cluster_583015 V1272609 CKC_01090 S VRR-NUC domain protein 122HE Cluster_589500 V1272611 BMUR_1332 S Domain of Unknown Function (DUF1599) 0XXR0 Cluster_633191 V1272612 S Protein of unknown function (DUF964) 102XZ Cluster_148109 V1272613 YEGQ map05120 O Peptidase U32 COG0826 Cluster_773887 V1272614 S relaxase mobilization nuclease domain protein 0XNXG Cluster_437053 V1272615 PHOU P Plays a role in the regulation of phosphate uptake COG0704 Cluster_267033 V1272616 PSTA map02010 P phosphate abc transporter COG0581 Cluster_537514 V1272617 L Integrase 0YTFQ Cluster_201906 V1272618 OPPF map02010 E, P ABC transporter, ATP-binding protein COG4608 Cluster_781381 V1272620 YOZG K Transcriptional regulator COG3655 Cluster_625649 V1272623 AROE map00400,map01100,map01110,map01230 E shikimate COG0169 Cluster_291348 V1272624 S GDSL-like protein 11TT5 Cluster_431063 V1272626 S NA 0ZS1W Cluster_153668 V1272628 MDTG G Major Facilitator 0ZVCH Cluster_828775 V1272629 TNPX L Site-specific recombinase COG1961 Cluster_329137 V1272630 S Phage replisome organizer 0ZW0Q Cluster_233745 V1272631 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_39486 V1272632 S Exporters of the RND superfamily COG1033 Cluster_416223 V1272633 K Transcriptional regulator, TetR family 11IM0 Cluster_95221 V1272634 S Pfam:LACT 0ZI03 Cluster_389495 V1272635 NTH map03410 L endonuclease III COG0177 Cluster_157844 V1272636 KBL map00260,map00780,map01100 H 2-amino-3-ketobutyrate coenzyme A ligase COG0156 Cluster_394846 V1272637 QUEG C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) COG1600 Cluster_363636 V1272639 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_852046 V1272641 S Toxin-antitoxin system, toxin component, RelE family 0XTKQ Cluster_487424 V1272644 S Gp157 family 11ZXY Cluster_665842 V1272646 S Phage replisome organizer 0YDCP Cluster_239918 V1272647 SP_0927 K Transcriptional regulator, LysR family COG0583 Cluster_855825 V1272648 S NA 11IN8 Cluster_610742 V1272649 HCP C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) COG1151 Cluster_16273 V1272650 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_614464 V1272651 V (ABC) transporter 0XQRE Cluster_250346 V1272652 map02020 T Histidine kinase COG0642 Cluster_840332 V1272653 T regulatoR COG0745 Cluster_492262 V1272654 T regulatoR COG0745 Cluster_821016 V1272655 S NA 121R1 Cluster_696133 V1272656 S Helix-turn-helix 0YHHT Cluster_59355 V1272657 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_231308 V1272658 MUTL map03430 L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) COG0323 Cluster_41523 V1272662 HPPA map00190 C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for COG3808 Cluster_26994 V1272664 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_447116 V1272665 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG0469 Cluster_211643 V1272666 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G Phosphohexokinase COG0205 Cluster_467338 V1272667 S acetyltransferase, (GNAT) family COG3981 Cluster_119915 V1272668 V Mate efflux family protein COG0534 Cluster_576653 V1272669 TIG O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COG0544 Cluster_836401 V1272671 S NA 11M4I Cluster_247779 V1272672 S SEFIR domain protein 0XQBT Cluster_127515 V1272674 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_261714 V1272676 S NA 1298D Cluster_251571 V1272677 E ABC, transporter COG0765 Cluster_280423 V1272678 ISPE map00900,map01100,map01110 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COG1947 Cluster_358817 V1272679 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_434983 V1272680 MAA E maltose O-acetyltransferase COG0110 Cluster_393031 V1272681 S integral membrane protein 11P1U Cluster_50767 V1272683 SNF L SNF2 family COG0553 Cluster_66584 V1272686 S DNA primase COG3378 Cluster_400084 V1272688 ENGB S Necessary for normal cell division and for the maintenance of normal septation (By similarity) COG0218 Cluster_64027 V1272691 CCRB L Resolvase COG1961 Cluster_372028 V1272692 L Transposase domain (DUF772) COG3666 Cluster_152071 V1272693 S NA 11K9E Cluster_176161 V1272695 S Rib/alpha-like repeat 10008 Cluster_241201 V1272696 NIT2 map00380,map00460,map00627,map00643,map00910,map01100,map01120 S Nitrilase COG0388 Cluster_90924 V1272697 YJGR S ATP-binding protein COG0433 Cluster_223180 V1272698 MSRB O reductase COG0229 Cluster_37806 V1272701 OPPA map02010 E Extracellular solute-binding protein, family 5 COG4166 Cluster_56256 V1272702 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_18865 V1272703 S Rib/alpha-like repeat 10008 Cluster_552090 V1272704 map00230 S Metal Dependent Phosphohydrolase 11UWJ Cluster_122852 V1272706 MURD map00471,map00550,map01100 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COG0771 Cluster_347395 V1272708 ACMA M defense response to bacterium COG1705 Cluster_173739 V1272710 C Aldo keto reductase COG1453 Cluster_19590 V1272711 S NA 0ZJGI Cluster_357168 V1272712 ASNA2 map00250,map00460,map00511,map00910,map01100,map01110,map04142 E asparaginase COG1446 Cluster_168562 V1272713 map00051,map00363,map00591,map00625,map00650,map01100,map01120 C alcohol dehydrogenase COG1979 Cluster_467339 V1272714 TPX O Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) COG2077 Cluster_342586 V1272716 RLUB J Pseudouridine synthase COG1187 Cluster_412578 V1272717 YTQB map00340,map00350,map00624,map01120 Q rRNA Methylase COG0500 Cluster_573445 V1272719 L Inherit from COG: transposase COG3385 Cluster_254039 V1272720 S DNA repair protein 0XQPN Cluster_162904 V1272722 VIRD4 map03070 U TraG TraD family protein COG3505 Cluster_238649 V1272723 H, P abc transporter atp-binding protein COG1120 Cluster_164513 V1272724 L Integrase COG0582 Cluster_191693 V1272725 S NA 0YM9S Cluster_330550 V1272726 PLSC map00561,map00564,map01100 I Acyl-transferase COG0204 Cluster_202951 V1272727 YHAN S domain protein COG4717 Cluster_318488 V1272729 CBIM map02010 P Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) COG0310 Cluster_98982 V1272730 GLGA map00500,map01100,map01110,map04973 G Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) COG0297 Cluster_20380 V1272731 U, W Pfam:YadA COG5295 Cluster_171999 V1272732 NUC L nuclease COG1525 Cluster_309342 V1272734 O ADP-ribosylglycohydrolase COG1397 Cluster_145742 V1272736 APEA map00480,map01100 E M18 family aminopeptidase COG1362 Cluster_751743 V1272737 TRKA P potassium transporter peripheral membrane COG0569 Cluster_400085 V1272741 FTHC map00670,map01100 H 5-formyltetrahydrofolate cyclo-ligase COG0212 Cluster_156981 V1272742 S F420-0:Gamma-glutamyl ligase 0Y085 Cluster_65403 V1272744 M Cell wall binding repeat 2-containing protein COG2247 Cluster_678966 V1272746 LANM V Lanthionine synthetase C family protein COG4403 Cluster_36004 V1272747 map02010 V ABC, transporter COG2274 Cluster_758713 V1272748 I Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) 0ZP33 Cluster_342587 V1272749 RNC map03008,map05205 K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) COG0571 Cluster_193516 V1272750 B, K radical SAM domain protein COG1243 Cluster_137501 V1272751 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_223181 V1272752 L NA 0YZ4U Cluster_400086 V1272755 S NA 1269Y Cluster_168563 V1272756 LTRA S low temperature requirement protein COG4292 Cluster_380636 V1272757 LEPB map03060 U Signal peptidase i COG0681 Cluster_79490 V1272762 L Recombinase COG1961 Cluster_76437 V1272763 HYMB map00190,map00910,map01100 C NADH dehydrogenase COG1894 Cluster_699405 V1272765 METE map00270,map00450,map01100,map01110,map01230 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) COG0620 Cluster_809407 V1272767 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_135095 V1272768 map00260,map00780,map01100 E Aminotransferase class I and II COG0156 Cluster_166900 V1272769 PMRB G Major Facilitator 11K1F Cluster_175365 V1272770 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_579777 V1272772 map02020,map03070 U Prokaryotic N-terminal methylation motif 0ZR0Y Cluster_163722 V1272773 GSPF map03070 U type ii secretion system COG1459 Cluster_355463 V1272774 MACB V Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) COG1136 Cluster_134298 V1272775 V Transporter Permease Protein COG0577 Cluster_259095 V1272776 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG0469 Cluster_445056 V1272777 MAZF T Toxic component of a toxin-antitoxin (TA) module (By similarity) COG2337 Cluster_234928 V1272779 COBD map00860,map01100 H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) COG1270 Cluster_70902 V1272780 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_27470 V1272783 PRIA map03440 L Primosomal protein n' COG1198 Cluster_22703 V1272784 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_241202 V1272785 M glycosyl transferase family COG0463 Cluster_670145 V1272786 GROS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) COG0234 Cluster_73526 V1272787 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_23127 V1272788 S NA 18A61@proNOG Cluster_755213 V1272789 GROS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) COG0234 Cluster_154480 V1272790 NATB C, P ABC transporter, permease COG1668 Cluster_840333 V1272791 YHCC S Radical SAM Protein COG1242 Cluster_621858 V1272792 S Protein of unknown function (DUF1292) 1248N Cluster_96312 V1272793 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_159566 V1272794 CODA map00240,map00330,map00791,map01100,map01120 F cytosine deaminase COG0402 Cluster_166173 V1272795 G Major Facilitator COG2814 Cluster_380637 V1272797 MURI map00230,map00240,map00471,map01100 M Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) COG0796 Cluster_67533 V1272799 CYDC map02010 V ABC transporter COG4988 Cluster_73872 V1272801 S Membrane COG4713 Cluster_348995 V1272802 M Glycosyl transferase family 2 COG0463 Cluster_50768 V1272803 MYCA S Myosin-Cross-Reactive Antigen COG4716 Cluster_398363 V1272805 S NA 0Y46D Cluster_90925 V1272806 PGCA map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_116313 V1272807 PURF map00230,map00250,map01100,map01110 F glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_715185 V1272808 S NA 0ZHT2 Cluster_405482 V1272809 ABIGI S Abortive infection protein AbiGI 11WH3 Cluster_339614 V1272810 S Abortive infection protein AbiGII 0XQHH Cluster_182107 V1272811 NRDF map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_124768 V1272815 L Integrase 0YTFQ Cluster_579778 V1272816 L site-specific recombinase, phage integrase family 0ZF8H Cluster_148110 V1272818 T Histidine kinase COG0642 Cluster_226664 V1272819 HTRA M peptidase S1 and S6, chymotrypsin Hap COG0265 Cluster_447117 V1272820 S -acetyltransferase 11PF0 Cluster_741653 V1272825 S NA 0YAQ6 Cluster_394847 V1272826 FLGJ map00511 N, U flagellar rod assembly protein muramidase flgj COG1705 Cluster_418024 V1272827 S Protein of unknown function (DUF1275) 0ZXV0 Cluster_657430 V1272828 YQGV S Domain of unknown function DUF77 COG0011 Cluster_150474 V1272829 PROTEASE map05120 O peptidase, U32 COG0826 Cluster_708625 V1272830 YABB map00340,map00350,map00624,map01120 L Methyltransferase COG4123 Cluster_303716 V1272831 RSMI G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 Cluster_237328 V1272832 S NurA domain protein 11IQE Cluster_443067 V1272833 THIW S thiw protein COG4732 Cluster_437054 V1272834 THIT S Proton-coupled thiamine transporter YuaJ COG3859 Cluster_288746 V1272835 V Mate efflux family protein COG0534 Cluster_227796 V1272837 ACOA map00010,map00020,map00620,map00650,map01100,map01110,map01120,map04066 C Pyruvate dehydrogenase COG1071 Cluster_231309 V1272839 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G phosphohexokinase COG0205 Cluster_741654 V1272841 SELB map00450,map00970 J Selenocysteine-specific translation elongation factor COG3276 Cluster_333602 V1272843 map00330,map01100 S Carbon-nitrogen hydrolase 11WGJ Cluster_255246 V1272846 SP_0899 S Membrane Associated 114SZ Cluster_127516 V1272847 RIBBA map00740,map01100 H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) COG0807 Cluster_429102 V1272848 map00630,map01100,map01110 S haloacid dehalogenase-like hydrolase COG0546 Cluster_260403 V1272849 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_324591 V1272850 PEPP E peptidase, M24 COG0006 Cluster_89981 V1272851 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_25707 V1272852 S NA 0YZ82 Cluster_372029 V1272853 REX K Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) COG2344 Cluster_355464 V1272854 YVDE J Glutamine amidotransferase COG2071 Cluster_321445 V1272855 RADC L DNA repair protein (RadC COG2003 Cluster_276445 V1272856 map00300,map01100,map01210,map01230 K Transcriptional regulator GntR family COG1167 Cluster_183840 V1272857 M chain length determinant protein 0Y1H4 Cluster_323009 V1272858 S TIM-barrel fold 11FGY Cluster_499928 V1272860 DEF J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) COG0242 Cluster_607091 V1272861 S conserved protein UCP033199 COG4898 Cluster_223182 V1272862 MDLA map02010 V ABC transporter, ATP-binding protein COG1132 Cluster_237329 V1272863 K Transcriptional Regulator AraC Family 0ZYR5 Cluster_625650 V1272864 map02010 V abc transporter COG1132 Cluster_238650 V1272865 OPPB map02010 P ABC transporter (Permease COG0601 Cluster_294078 V1272867 RRMJ J Hemolysin A COG1189 Cluster_255247 V1272868 ISPA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_537515 V1272871 ISCU C SUF system FeS assembly protein, NifU family COG0822 Cluster_216174 V1272872 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_180361 V1272873 NUOH map00190,map00910,map01100 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) COG1005 Cluster_285985 V1272876 GLK map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G Glucokinase COG1940 Cluster_419811 V1272879 RPSP map03010 J 30s ribosomal protein S16 COG0228 Cluster_43713 V1272881 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_198929 V1272882 WANG_1265 L transposase IS605 OrfB family 0XT7Q Cluster_216175 V1272885 CPOA M Glycosyl transferase COG0438 Cluster_213841 V1272886 CCPA K catabolite control protein a COG1609 Cluster_76770 V1272887 DCM map00270,map01100 L C-5 cytosine-specific DNA methylase COG0270 Cluster_230135 V1272889 FNI map00900,map01100,map01110 C Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) COG1304 Cluster_526236 V1272890 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_38681 V1272891 RPSA map00900,map01100,map01110,map03010 J Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) COG0761 Cluster_181179 V1272893 V ABC transporter transmembrane region COG1132 Cluster_107649 V1272894 MURE map00300,map00550,map01100 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_122178 V1272895 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_403656 V1272896 YQGX map00620 Q domain protein COG0491 Cluster_599870 V1272897 DTD J Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) COG1490 Cluster_398364 V1272898 REPA L Replication initiator protein A 0YDCP Cluster_341064 V1272901 S membrane 11HPM Cluster_469449 V1272902 RIMM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) COG0806 Cluster_777572 V1272903 S fad dependent oxidoreductase 0XQG1 Cluster_393032 V1272906 LEXA K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) COG1974 Cluster_148847 V1272907 YNBB map00260,map00270,map00450,map01100,map01230 P aluminum resistance protein COG4100 Cluster_362070 V1272908 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_360487 V1272909 T Histidine kinase COG0642 Cluster_219655 V1272910 MANX map00051,map00520,map01100,map02060 G pts system COG3444 Cluster_42961 V1272912 MTLR K TRANSCRIPTIONal COG3711 Cluster_797237 V1272913 K HTH_XRE 123HS Cluster_589501 V1272914 S NA 11JTA Cluster_263007 V1272915 NUOB map00190,map00910,map01100 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) COG0377 Cluster_329138 V1272916 SRTA M (sortase) family COG3764 Cluster_283156 V1272918 WHIA K May be required for sporulation (By similarity) COG1481 Cluster_537517 V1272919 CG3417 map00230,map00240 L nudix hydrolase COG0494 Cluster_372030 V1272920 K Transcriptional regulator COG1309 Cluster_277752 V1272921 E, G Membrane COG0697 Cluster_362071 V1272922 GPMA map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0588 Cluster_396627 V1272923 NUSB K Involved in the transcription termination process (By similarity) COG0781 Cluster_93307 V1272924 POTC map02010 P putrescine abc transporter COG1177 Cluster_143487 V1272926 C radical SAM domain protein COG1032 Cluster_358818 V1272927 SCLAV_1770 S Radical SAM-linked protein COG5011 Cluster_692405 V1272929 S smc domain-containing protein 0XTF4 Cluster_762527 V1272930 S NA 0XYB0 Cluster_373650 V1272931 S Chromosome segregation ATPase 11HKQ Cluster_661629 V1272932 YERC S protein, YerC YecD COG4496 Cluster_375362 V1272933 FBPA K Fibronectin-binding protein COG1293 Cluster_234929 V1272934 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_408915 V1272935 S Membrane 0ZU9D Cluster_357169 V1272936 map02010 P Cobalt transport protein COG0619 Cluster_360488 V1272937 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_197931 V1272938 COIA S Competence protein COG4469 Cluster_437055 V1272939 S NA 0XV44 Cluster_443068 V1272941 map00230 F Adenylate cyclase COG1437 Cluster_357170 V1272942 CP_0141 S metallophosphoesterase COG1768 Cluster_797238 V1272943 RPMC map03010 J 50s ribosomal protein l29 COG0255 Cluster_738260 V1272944 RPSQ map03010 J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal COG0186 Cluster_223183 V1272945 OPPB map02010 P ABC transporter (permease) COG0601 Cluster_129627 V1272946 YIEG S Xanthine uracil vitamin C permease COG2252 Cluster_497261 V1272947 map00511 G Alpha-L-fucosidase COG3669 Cluster_570216 V1272948 RPLL map03010 J Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) COG0222 Cluster_365376 V1272949 INFC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) COG0290 Cluster_741655 V1272951 S Hypothetical bacterial integral membrane protein (Trep_Strep) 11MJD Cluster_512626 V1272953 RV1290C S Membrane COG4325 Cluster_83811 V1272954 NHAC map00680 C Na H antiporter COG1757 Cluster_127517 V1272955 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_193517 V1272956 ECORIM L Modification methylase EcoRI 0XPU0 Cluster_678967 V1272957 T FHA Domain-Containing protein 0XUTQ Cluster_67158 V1272958 TRAA map03440 L mobA MobL family protein COG0507 Cluster_294079 V1272959 YCGQ S transporter substrate-binding protein COG3689 Cluster_112062 V1272960 S NA 11YT1 Cluster_34918 V1272963 FTSI map00550,map01100 M penicillin-binding protein COG0768 Cluster_447118 V1272964 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_52144 V1272966 HTPG map04141,map04151,map04612,map04621,map04626,map04914,map04915,map05200,map05215 O Molecular chaperone. Has ATPase activity (By similarity) COG0326 Cluster_136710 V1272967 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_482807 V1272968 S Domain of unknown function (DUF3127) 126YQ Cluster_76771 V1272970 DPPA E Extracellular solute-binding protein, family 5 COG0747 Cluster_131914 V1272971 COPA P p-type ATPase COG2217 Cluster_85549 V1272973 S Domain of unknown function(DUF2779) 0XQMU Cluster_219656 V1272974 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_66585 V1272976 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 Cluster_731682 V1272978 YLXR K Nucleic-acid-binding protein implicated in transcription termination COG2740 Cluster_175366 V1272979 NUSA K Transcription elongation factor NusA COG0195 Cluster_315375 V1272982 TTCA D Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) COG0037 Cluster_318489 V1272984 UBIE map00340,map00350,map00624,map01120 Q methyltransferase COG0500 Cluster_120637 V1272986 M Polysaccharide Biosynthesis Protein 0XP95 Cluster_318490 V1272987 K, T Peptidase m56 COG4219 Cluster_217367 V1272990 YABE M domain protein COG3584 Cluster_276446 V1272991 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_473709 V1272992 TPX O Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) COG2077 Cluster_461052 V1272993 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_319965 V1272997 S NA 11J2B Cluster_36692 V1272998 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_557901 V1273000 RSEP map04112 M Membrane-associated zinc metalloprotease COG0750 Cluster_184719 V1273001 ISPG map00900,map01100,map01110 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) COG0821 Cluster_741656 V1273005 S Transglycosylase-associated protein 125P9 Cluster_241203 V1273006 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_234930 V1273007 G polysaccharide deacetylase COG0726 Cluster_122179 V1273009 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_546168 V1273010 S recombinase 11R6K Cluster_79801 V1273011 L Recombinase COG1961 Cluster_216176 V1273013 BL02377 S S-adenosyl-l-methionine hydroxide adenosyltransferase COG1912 Cluster_90440 V1273015 S Virulence-associated protein e COG5545 Cluster_187346 V1273016 YFML L atp-dependent rna helicase COG0513 Cluster_467340 V1273017 S Nitroreductase 11NZA Cluster_200922 V1273018 HOLA map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii, delta' subunit COG1466 Cluster_408916 V1273019 RECR map03440 L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) COG0353 Cluster_586210 V1273020 V i restriction-modification system COG0732 Cluster_332093 V1273022 FABG map00061,map00780,map01040,map01100 S reductase 0XNW1 Cluster_209430 V1273024 YLBM S UPF0348 protein COG1323 Cluster_487425 V1273027 GREA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) COG0782 Cluster_683543 V1273028 TRAE S conjugative transposon protein TraE 11QVH Cluster_543235 V1273029 M RHS repeat-associated core domain protein COG3209 Cluster_296834 V1273030 M RHS repeat-associated core domain protein COG3209 Cluster_173740 V1273031 OPPC map02010 P ABC transporter (Permease COG1173 Cluster_645115 V1273034 WANG_1499 S Transposase 11N3I Cluster_844367 V1273038 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_245188 V1273039 CBPA O DnaJ domain protein COG2214 Cluster_121414 V1273043 VIRE L Virulence-associated protein e COG5545 Cluster_64852 V1273045 map02010 E Nickel ABC transporter, periplasmic nickel-binding protein COG0747 Cluster_232487 V1273047 YPUA S secreted protein COG4086 Cluster_629352 V1273048 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_492263 V1273049 YBEY map00240,map00983,map01100 F Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) COG0319 Cluster_250347 V1273050 PHOH T Phoh family COG1702 Cluster_72493 V1273051 PROTEASE map05120 O Peptidase U32 COG0826 Cluster_410758 V1273053 RNFE C Electron transport complex COG4660 Cluster_421615 V1273054 RNFA C Electron transport complex COG4657 Cluster_37180 V1273055 S NA 0YH2T Cluster_360489 V1273056 YRRM map00340,map00350,map00360,map00624,map00940,map00941,map00945,map01100,map01110,map01120 S O-methyltransferase COG4122 Cluster_307920 V1273057 PRSA O Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) COG0760 Cluster_321446 V1273058 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_183010 V1273060 COMEC S ComEC rec2-like protein COG0658 Cluster_373651 V1273061 ADK map00230,map00240,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_135096 V1273062 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_156982 V1273063 V abc transporter permease protein 0ZW5X Cluster_347396 V1273064 TILS D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) COG0037 Cluster_702443 V1273066 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_206167 V1273067 PHOH T Phoh family COG1702 Cluster_58047 V1273068 S Inherit from NOG: antigen PG97 COG4886 Cluster_410759 V1273070 PLSY map00561,map00564,map01100 S Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) COG0344 Cluster_294080 V1273071 RSMI G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 Cluster_152906 V1273072 YEGQ map05120 O Peptidase U32 COG0826 Cluster_372031 V1273073 GLSA map00250,map00330,map00471,map00910,map01100,map01120,map04724,map04727,map04964 E Glutaminase COG2066 Cluster_108820 V1273074 AGCS E amino acid carrier protein COG1115 Cluster_194448 V1273075 S Inherit from COG: LOR SDH bifunctional protein conserved domain protein COG1915 Cluster_119153 V1273077 S NA 0ZX1V Cluster_610743 V1273078 XFP map00030,map00680,map00710,map01100,map01120 G Phosphoketolase COG3957 Cluster_170358 V1273082 L Resolvase COG1961 Cluster_766472 V1273083 S conjugative transposon protein 11UEH Cluster_48966 V1273085 M Inherit from COG: YD repeat protein COG3209 Cluster_421616 V1273086 RIML J acetyltransferase, (GNAT) family COG1670 Cluster_71524 V1273088 PGCA map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_546169 V1273089 CARD K Transcriptional regulator (CarD family COG1329 Cluster_119154 V1273090 CAT map00281,map00620,map00626,map01110,map01120 C Transferase COG0427 Cluster_758715 V1273092 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_497262 V1273093 MUTX L mutator MutT protein COG0494 Cluster_135097 V1273094 PYRC map00240,map01100 F dihydroorotase COG0044 Cluster_189048 V1273095 TAUA map02010 P Taurine ABC transporter, periplasmic COG4521 Cluster_175367 V1273096 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_263008 V1273097 RPLY map03010 J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) COG1825 Cluster_79491 V1273098 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_412580 V1273100 S Copper amine oxidase domain protein 121X1 Cluster_117022 V1273101 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_178659 V1273102 L tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) COG0582 Cluster_252790 V1273103 S NA 0Y8RQ Cluster_174557 V1273104 S Phage portal protein, SPP1 Gp6-like 11J8D Cluster_50170 V1273105 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_465245 V1273107 YDCQ D ftsk SpoIIIE family protein COG1674 Cluster_96833 V1273108 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_219657 V1273109 S CAAX protease self-immunity 0XUJM Cluster_385970 V1273110 YLFI S integral membrane protein COG4478 Cluster_579779 V1273112 RPLL map03010 J Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) COG0222 Cluster_455056 V1273113 RPLJ map03010 J 50s ribosomal protein L10 COG0244 Cluster_162069 V1273114 TOCE_0081 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_355465 V1273116 COAB map00770,map01100 H DNA pantothenate metabolism flavoprotein domain protein COG0452 Cluster_271100 V1273117 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_178660 V1273118 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_192623 V1273119 map03420,map03430 S UvrD/REP helicase N-terminal domain 0ZB44 Cluster_267034 V1273120 S NA 0XR66 Cluster_141292 V1273121 map00660,map01100 E Methylaspartate ammonia-lyase COG3799 Cluster_122180 V1273122 S NA 0ZX1V Cluster_122181 V1273123 PEPC E aminopeptidase c COG3579 Cluster_264389 V1273124 M RHS repeat-associated core domain protein COG3209 Cluster_232488 V1273125 PSTS2 map02010,map02020,map05152 P Phosphate-binding protein COG0226 Cluster_263009 V1273126 PSTC map02010 P phosphate abc transporter COG0581 Cluster_502467 V1273127 S Resistance protein COG3467 Cluster_348996 V1273129 FEOB P Ferrous iron transport protein B COG0370 Cluster_507448 V1273130 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_437056 V1273131 NUDF map00230 F nudix hydrolase COG0494 Cluster_762530 V1273133 S excisionase 11SUH Cluster_191694 V1273138 S CHAP domain COG3942 Cluster_155313 V1273139 ARCA map00330,map01100,map01110 E Arginine dihydrolase COG2235 Cluster_358819 V1273141 CPHY_2173 L Transposase 11J2V Cluster_353782 V1273142 BL00144 L Transposase COG2801 Cluster_182108 V1273143 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_449130 V1273144 FTSQ map04112 M domain protein, FtsQ-type COG1589 Cluster_219658 V1273145 CLCAR_1091 T Histidine kinase COG0642 Cluster_360490 V1273147 ZNUA map02010 P periplasmic solute binding protein COG0803 Cluster_389496 V1273148 VNCS T Histidine kinase COG0642 Cluster_305227 V1273149 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_423467 V1273150 CYSE S -acetyltransferase 11PF0 Cluster_625651 V1273151 L site-specific recombinase, phage integrase family 0ZJK4 Cluster_287385 V1273152 V permease 0YATZ Cluster_199925 V1273153 CYCMA_1561 L Transposase COG3436 Cluster_166901 V1273154 SERP0565 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_250348 V1273155 C Binding Domain protein COG0348 Cluster_637245 V1273156 RPLV map03010 J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) COG0091 Cluster_96313 V1273157 map02020 T Sensor histidine kinase 1254H Cluster_543236 V1273159 K Inherit from COG: Transcriptional regulator COG2508 Cluster_246530 V1273160 I Lipid kinase, YegS Rv2252 BmrU family COG1597 Cluster_431064 V1273161 RIML J acetyltransferase, (GNAT) family COG1670 Cluster_46932 V1273163 ARSA D Arsenite-activated ATPase (ArsA) COG0003 Cluster_53521 V1273164 GLTD map00250,map00910,map01100,map01110,map01120,map01230 E Pyridine nucleotide-disulphide oxidoreductase COG1894 Cluster_273756 V1273165 FBA map00010,map00030,map00051,map00052,map00680,map00710,map01100,map01110,map01120,map01230 G aldolase COG0191 Cluster_362073 V1273166 map00630,map01100,map01110 S had-superfamily hydrolase, subfamily ia, variant COG0546 Cluster_625652 V1273167 H thiF family COG0476 Cluster_52145 V1273168 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_360491 V1273169 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_762531 V1273170 RNC map03008,map05205 K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) COG0571 Cluster_143488 V1273171 YXIO G major facilitator superfamily COG2270 Cluster_540310 V1273172 S Membrane 12424 Cluster_705552 V1273174 VAPD S Virulence-associated protein D COG3309 Cluster_674538 V1273176 GROS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) COG0234 Cluster_607092 V1273177 F nucleoside COG3613 Cluster_206168 V1273179 OPPC map02010 P abc transporter, permease COG1173 Cluster_419812 V1273180 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_217368 V1273181 GPSA map00564 C NADPH-dependent glycerol-3-phosphate dehydrogenase COG0240 Cluster_360492 V1273184 XYLG S ABC transporter COG3845 Cluster_75795 V1273185 map00190,map00680,map01100 C ATP synthase alpha/beta chain, C terminal domain COG1155 Cluster_670146 V1273186 NTPG map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG1436 Cluster_801209 V1273187 map02010 E PBPb COG0834 Cluster_225546 V1273188 TEH_04440 map00052,map01100,map02060 G PTS system, galactitol-specific IIc component COG3775 Cluster_721738 V1273189 RBSK map00030 G ribokinase COG0524 Cluster_848254 V1273191 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_201907 V1273192 POTD map02010 E ABC transporter COG0687 Cluster_384188 V1273193 POTC map02010 P putrescine abc transporter COG1177 Cluster_88587 V1273194 FLIC map02020,map02040,map04626,map05132,map05134 N Flagellin COG1344 Cluster_570217 V1273195 S relaxase mobilization nuclease domain protein 0XNXG Cluster_124769 V1273197 S s-layer domain-containing protein 11WIT Cluster_370400 V1273198 S NA 12BYG Cluster_793265 V1273199 S NA 0ZVJP Cluster_259096 V1273200 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_876242 V1273203 M (sortase) family COG3764 Cluster_285986 V1273204 SRTC M (sortase) family COG3764 Cluster_223184 V1273205 SRTB M (sortase) family COG3764 Cluster_131915 V1273206 map03420,map03430 L helicase COG0210 Cluster_405483 V1273207 RECO map03440 L Involved in DNA repair and RecF pathway recombination (By similarity) COG1381 Cluster_127518 V1273208 V Mate efflux family protein COG0534 Cluster_465246 V1273209 RV1290C S Membrane COG4325 Cluster_384189 V1273210 ELI_3039 K RNA Polymerase 1261F Cluster_283157 V1273211 AMAA map00360 E Peptidase dimerisation domain COG1473 Cluster_47298 V1273212 S NA 0YZ82 Cluster_294081 V1273215 REPA L Replication initiator protein A 0YDCP Cluster_52598 V1273216 CADA P p-type atpase COG2217 Cluster_641238 V1273217 S conjugative transposon membrane protein 11G5T Cluster_273757 V1273218 S conjugative transposon membrane protein 0XPC1 Cluster_789479 V1273219 S NA 11TQ2 Cluster_126114 V1273223 ZNUA map02010 P transporter substrate-binding protein COG0803 Cluster_433082 V1273224 O AhpC Tsa family 0ZVMV Cluster_298232 V1273225 SP_0675 S short chain dehydrogenase reductase family COG0300 Cluster_309343 V1273226 S NA 11ISF Cluster_310776 V1273227 S TraX protein 11N9P Cluster_678969 V1273230 CAS2 L CRISPR-associated protein cas2 11VHR Cluster_201908 V1273231 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG2812 Cluster_469450 V1273232 SP_0805 S hydrolase COG0546 Cluster_48324 V1273233 M NA 0ZYVM Cluster_377136 V1273237 PHOU P Plays a role in the regulation of phosphate uptake COG0704 Cluster_86828 V1273238 V Type III restriction enzyme, res subunit 0Y2F5 Cluster_82555 V1273239 BA_0233 E, P ABC transporter, permease protein COG1173 Cluster_232489 V1273240 L Group II intron, maturase-specific domain COG3344 Cluster_592899 V1273241 TONB M TonB family 11HUD Cluster_134299 V1273242 S Relaxase mobilization nuclease 0Y9PG Cluster_576654 V1273243 S NA 0YIA5 Cluster_687976 V1273245 S NA 121AE Cluster_338192 V1273246 S NA 0Z81M Cluster_237330 V1273247 S phage protein 0XQDU Cluster_332094 V1273248 AROE map00400,map01100,map01110,map01230 E shikimate dehydrogenase COG0169 Cluster_549203 V1273249 S NA 0ZHU9 Cluster_567129 V1273251 S NA 0YGHY Cluster_708626 V1273252 S NA 0YPQQ Cluster_419813 V1273253 U TraG family COG3505 Cluster_718437 V1273254 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_224375 V1273255 L metallophosphoesterase COG0420 Cluster_396628 V1273256 S smc domain-containing protein 0XTF4 Cluster_157845 V1273257 HTRA O serine protease COG0265 Cluster_73154 V1273258 V ABC transporter COG1132 Cluster_65704 V1273259 S conserved domain protein 11Q3F Cluster_93308 V1273261 FEOB P Ferrous iron transport protein b COG0370 Cluster_360493 V1273262 LIPA map00785,map01100 H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) COG0320 Cluster_151238 V1273263 HGDA map00362,map01100,map01120,map01220 E dehydratase COG1775 Cluster_380638 V1273264 HGDB E dehydratase COG1775 Cluster_239919 V1273265 S RelA SpoT domain protein 0XPFE Cluster_51334 V1273266 M polymorphic outer membrane protein 127DI Cluster_73155 V1273267 S NA 0XWEM Cluster_174558 V1273268 S NA 11SVT Cluster_321447 V1273273 MANY map00051,map00520,map01100,map02060 G PTS System COG3715 Cluster_251572 V1273274 MANN map00051,map00520,map01100,map02060 G PTS system mannose fructose sorbose family transporter subunit IID COG3716 Cluster_144996 V1273275 GLYA map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01230 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) COG0112 Cluster_393033 V1273276 S NA 187CD@proNOG Cluster_89982 V1273277 C Hydrogenase large subunit domain protein COG4624 Cluster_718438 V1273278 S Pfam:Complex1_24kDa 0XVAK Cluster_228963 V1273279 YAET M outer membrane protein assembly complex, YaeT protein COG4775 Cluster_589503 V1273280 POTA map02010 E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COG3842 Cluster_347398 V1273281 S Membrane COG3503 Cluster_265715 V1273284 S degv family COG1307 Cluster_512627 V1273289 FUR P Ferric uptake COG0735 Cluster_336639 V1273290 M Sulfatase COG1368 Cluster_852049 V1273291 RUBR C rubredoxin COG1773 Cluster_199926 V1273292 YHAO L DNA repair exonuclease COG0420 Cluster_305228 V1273293 YHAN S domain protein COG4717 Cluster_347399 V1273294 DGKA map00561,map00564,map01100,map04070 M Diacylglycerol kinase COG0818 Cluster_563930 V1273295 CDD map00240,map00983,map01100,map05219 F cytidine deaminase COG0295 Cluster_398365 V1273296 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_344188 V1273297 RLMB map00340,map00350,map00624,map01120 J RNA methyltransferase TrmH family group 3 COG0566 Cluster_892450 V1273298 PCP O Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) COG2039 Cluster_246531 V1273299 PSUG map00240 Q Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) COG2313 Cluster_150475 V1273300 map00360 E amidohydrolase COG1473 Cluster_543237 V1273301 CODA map00240,map00330,map00791,map01100,map01120 F cytosine deaminase COG0402 Cluster_518011 V1273302 RADC2 L DNA repair protein (RadC COG2003 Cluster_711820 V1273303 YHGE S domain protein COG1511 Cluster_633192 V1273304 S NA 0ZHT2 Cluster_614467 V1273305 RARA L recombination factor protein RarA COG2256 Cluster_563931 V1273306 S Bacterial mobilisation protein (MobC) 11K3U Cluster_165362 V1273307 S Relaxase Mobilization nuclease domain protein 0XRAY Cluster_91396 V1273308 UMUC L ImpB MucB SamB family protein COG0389 Cluster_55507 V1273309 V type I restriction-modification COG0732 Cluster_232490 V1273311 APPC map02010 P ABC superfamily ATP binding cassette transporter ABC protein COG1173 Cluster_178661 V1273312 S Copper amine oxidase domain protein 0ZW5W Cluster_373653 V1273315 S NA 11NM2 Cluster_222002 V1273316 map00860,map01100,map01110 C radical SAM domain protein COG1032 Cluster_434985 V1273317 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_288747 V1273319 S Membrane COG2035 Cluster_319967 V1273321 YCJV map02010 G Abc transporter COG3839 Cluster_546170 V1273322 MRNC S Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) COG1939 Cluster_400088 V1273323 NAMU_0682 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_552091 V1273324 V Restriction modification system DNA (Specificity COG0732 Cluster_217369 V1273325 YRAJ map05133 M outer membrane usher protein COG3188 Cluster_307921 V1273326 YRAK S Fimbrial protein 17E3Z@proNOG Cluster_263010 V1273327 PSTA map02010 P phosphate ABC transporter (Permease COG0581 Cluster_115582 V1273329 CYCMA_0607 S transposase 11H93 Cluster_439073 V1273331 NUDF map00230 F nudix hydrolase COG0494 Cluster_135903 V1273332 E 2-hydroxyglutaryl-CoA dehydratase COG1775 Cluster_683544 V1273333 S Protein of unknown function (DUF3343) 0XTWJ Cluster_220850 V1273336 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_625653 V1273337 METN map02010 P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COG1135 Cluster_119155 V1273338 UGPB map02010 G extracellular solute-binding protein family 1 COG1653 Cluster_57776 V1273339 POLA_2 L DNA polymerase 0XRUF Cluster_316899 V1273340 TATD L Hydrolase, tatD family COG0084 Cluster_431066 V1273341 RNMV L Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) COG1658 Cluster_338193 V1273342 S NA 0Z20Q Cluster_475882 V1273343 S isoprenylcysteine carboxyl methyltransferase family protein 0ZWP8 Cluster_453040 V1273344 S Toxin-antitoxin system, toxin component, Fic family COG3943 Cluster_93309 V1273346 S (Histidine triad) protein 11RAF Cluster_653301 V1273347 MIHF S integration host factor 11UU9 Cluster_734925 V1273348 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_292695 V1273349 CYDC map02010 V ABC transporter COG4988 Cluster_385971 V1273350 S corrinoid protein 11G0X Cluster_699406 V1273352 S NA 0ZHU9 Cluster_507449 V1273353 S Protein of unknown function (DUF3408) 11QAR Cluster_480473 V1273354 PEPC E aminopeptidase c COG3579 Cluster_161231 V1273355 SPOVK O AAA ATPase, central domain protein COG0464 Cluster_461053 V1273356 RPIB map00030,map00052,map00710,map01100,map01110,map01120,map01230 G galactose-6-phosphate isomerase subunit LacB COG0698 Cluster_348997 V1273363 SCPA S Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) COG1354 Cluster_372032 V1273365 map02010 P ABC transporter COG1121 Cluster_332095 V1273366 GATB map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 Cluster_60971 V1273368 LYSC map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Aspartokinase COG0527 Cluster_210512 V1273371 map00311,map00312,map01110,map02020 V Beta-lactamase COG2367 Cluster_353783 V1273372 MALF map02010 P binding-protein-dependent transport systems inner membrane Component 0Y7BF Cluster_259097 V1273373 MALD map02010 P ABC transporter, permease COG3833 Cluster_872142 V1273374 MALK map02010 G ATP-binding protein COG3839 Cluster_372033 V1273375 UVRD map03420,map03430 L ATP-dependent DNA helicase COG0210 Cluster_211644 V1273376 GAP map00010,map01100,map01110,map01120,map01230,map04066,map05010 G glyceraldehyde-3-phosphate dehydrogenase COG0057 Cluster_375363 V1273378 S NA 0YFUK Cluster_80593 V1273379 map02010 V ABC transporter COG1132 Cluster_708627 V1273380 S VRR-NUC domain protein 122HE Cluster_408917 V1273381 K, L domain protein COG0553 Cluster_80173 V1273382 S NA 0YZ82 Cluster_287386 V1273384 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_74193 V1273385 S Ricin-type beta-trefoil lectin domain 124S7 Cluster_181180 V1273386 T Pasta domain containing protein COG2815 Cluster_423468 V1273387 HSDR V Type I Restriction COG0610 Cluster_309344 V1273388 METY map00270,map00450,map00920,map01100,map01110,map01230 E Cys/Met metabolism PLP-dependent enzyme COG2873 Cluster_275115 V1273389 M NA 0ZP9N Cluster_437057 V1273390 AROB map00230,map00400,map01100,map01110,map01230 E 3-dehydroquinate synthase COG0337 Cluster_900909 V1273391 CHBA map02060 G PTS System COG1447 Cluster_257769 V1273392 RLUD J pseudouridine synthase COG0564 Cluster_563932 V1273393 K TRANSCRIPTIONAl REGULATOR GntR family COG1725 Cluster_384190 V1273394 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_64028 V1273395 S NA 101UU Cluster_90926 V1273396 PHOA map00627,map00790,map01100,map01120,map02020 P alkaline phosphatase COG1785 Cluster_93310 V1273397 YJGR S ATP-binding protein COG0433 Cluster_215034 V1273398 PLSX map00561,map00564,map01100 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) COG0416 Cluster_770189 V1273399 ACPP I Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) COG0236 Cluster_385972 V1273400 TMK map00240,map01100 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) COG0125 Cluster_64580 V1273402 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_88588 V1273403 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_563933 V1273404 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III alpha subunit COG0587 Cluster_731684 V1273405 PTSH G phosphocarrier protein (HPr COG1925 Cluster_237331 V1273406 WHIA K May be required for sporulation (By similarity) COG1481 Cluster_437058 V1273407 STPC map02010 V ABC transporter COG1131 Cluster_586211 V1273409 YHCF K TRANSCRIPTIONAl REGULATOR GntR family COG1725 Cluster_339615 V1273410 S Uncharacterized conserved protein (DUF2075) 0XPB6 Cluster_288748 V1273411 S Calcineurin-like phosphoesterase COG1408 Cluster_212732 V1273412 DGT map00230 F deoxyguanosinetriphosphate triphosphohydrolase-like protein COG0232 Cluster_708628 V1273413 DNAG map03030 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 Cluster_91397 V1273414 S Membrane 0XQXB Cluster_250349 V1273416 P ABC transporter substrate-binding protein 1C9NV@synNOG Cluster_65999 V1273418 U, W Pfam:YadA COG5295 Cluster_310777 V1273419 L Site-specific recombinase COG1961 Cluster_242575 V1273420 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_471616 V1273421 MRAZ S Cell division protein mraZ COG2001 Cluster_99508 V1273422 map05100 S repeat protein 11TEE Cluster_801210 V1273423 map00400,map01100,map01110,map01230 S NA 11PW2 Cluster_216177 V1273424 CMK map00240,map00410,map00770,map01100,map01110 F Cytidine monophosphate kinase COG4401 Cluster_405484 V1273425 YTFP S hi0933 family COG2081 Cluster_789480 V1273426 MACB map02010 V abc transporter permease protein COG0577 Cluster_637246 V1273427 ASNB map00250,map00910,map01100,map01110,map01120 E asparagine synthetase COG0367 Cluster_661630 V1273428 YADS S Membrane COG2860 Cluster_537521 V1273429 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_412581 V1273430 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_204000 V1273431 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_216178 V1273432 S copper amine 0XP8R Cluster_294082 V1273433 M Inherit from NOG: domain protein 0XQTW Cluster_755215 V1273436 L Transposase COG2801 Cluster_674539 V1273438 S NA 12378 Cluster_793268 V1273439 PYRC map00240,map01100 F Amidohydrolase family COG0044 Cluster_335114 V1273440 V abc transporter atp-binding protein COG1131 Cluster_473711 V1273442 DPPC map02010 P abc transporter, permease COG1173 Cluster_176162 V1273445 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_237332 V1273446 TRXB map00240,map00450 O thioredoxin reductase COG0492 Cluster_661631 V1273447 TRXA O Thioredoxin COG0526 Cluster_249092 V1273448 LIGB map03030,map03410,map03420,map03430 L Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) COG0272 Cluster_162070 V1273449 CASA L crispr-associated protein 0XPA1 Cluster_348998 V1273450 RECO map03440 L Involved in DNA repair and RecF pathway recombination (By similarity) COG1381 Cluster_797239 V1273451 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_621859 V1273452 SUFD O feS assembly protein SufD COG0719 Cluster_81764 V1273453 RNY S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 Cluster_295483 V1273455 K protein, AraC type 11XHA Cluster_583017 V1273456 MHQR K transcriptional regulator), MarR family 11UT8 Cluster_482808 V1273457 S Peptidase propeptide and YPEB domain protein COG5353 Cluster_69621 V1273458 PGCA map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_100577 V1273460 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_357171 V1273461 S phage protein 0XQDU Cluster_665844 V1273462 S rRNA biogenesis protein Rrp5 0XUK3 Cluster_117023 V1273469 T Histidine kinase COG0642 Cluster_370401 V1273470 map02020 K Transcriptional Regulator AraC Family COG4753 Cluster_75176 V1273472 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_220851 V1273474 DHDH G oxidoreductase COG0673 Cluster_145743 V1273475 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_80174 V1273476 S s-layer domain-containing protein 0YAE9 Cluster_367071 V1273477 MREC M Involved in formation and maintenance of cell shape (By similarity) COG1792 Cluster_196177 V1273479 YLBL T domain protein COG3480 Cluster_161232 V1273480 P Sodium hydrogen exchanger 0XRVN Cluster_319968 V1273481 S peptidase, S41 11FNN Cluster_475883 V1273482 S peptidase, S41 11FNN Cluster_721739 V1273483 S prevent-host-death family 0ZX42 Cluster_674540 V1273484 S Toxin-antitoxin system, toxin component, RelE family 123KX Cluster_439074 V1273485 FHUD map02010 P Periplasmic binding protein COG0614 Cluster_102278 V1273486 S Inherit from COG: leucine Rich Repeat COG4886 Cluster_90441 V1273487 map03420,map03430 L DNA helicase 0XQN2 Cluster_242576 V1273488 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_178662 V1273489 HEMN map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_480474 V1273490 S Metal dependent phosphohydrolase COG1418 Cluster_848256 V1273491 S mobilization protein 11J0G Cluster_785476 V1273492 S Abortive infection protein AbiGII 0XQHH Cluster_738261 V1273494 D, J addiction module toxin, RelE StbE family COG2026 Cluster_333603 V1273495 MYCA S Myosin-Cross-Reactive Antigen COG4716 Cluster_507450 V1273497 THIN map00730,map01100 H thiamine COG1564 Cluster_523328 V1273499 PAT map00440,map01110 M -acetyltransferase COG1247 Cluster_365378 V1273500 ALKD L DNA alkylation repair enzyme COG4912 Cluster_77141 V1273501 S NA 101UU Cluster_670147 V1273502 HYCE map00190 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) COG3262 Cluster_239920 V1273503 PAFA S type i phosphodiesterase nucleotide pyrophosphatase COG1524 Cluster_375364 V1273504 ACUB S (CBS) domain COG0517 Cluster_83019 V1273505 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_531834 V1273507 U traE protein COG3451 Cluster_223185 V1273511 BCGIA V Type II restriction modification enzyme methyltransferase COG0286 Cluster_391223 V1273512 S NA 0ZBGF Cluster_507451 V1273513 S peptidase, S41 11FNN Cluster_344189 V1273514 S peptidase, S41 11FNN Cluster_161233 V1273515 NAGE map00010,map00500,map00520,map02060 G PTS System COG1263 Cluster_583018 V1273516 SSCG_04339 S membrAne COG0628 Cluster_83812 V1273517 LANM V Lanthionine synthetase C family protein COG4403 Cluster_150476 V1273518 MEGL map00260,map00270,map00450,map00920,map01100,map01110,map01230 E methionine gamma-lyase COG0626 Cluster_431067 V1273520 S Phage-associated protein 11FS5 Cluster_183011 V1273524 S domain protein 0Y8F3 Cluster_263011 V1273525 M RHS repeat-associated core domain protein COG3209 Cluster_78120 V1273526 V ABC transporter COG1132 Cluster_78121 V1273527 ALGI M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_78794 V1273528 M NA 0YHI1 Cluster_78795 V1273529 S NA 0YZ82 Cluster_781383 V1273531 YQFL S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) COG1806 Cluster_157846 V1273533 YTFP S hi0933 family COG2081 Cluster_365379 V1273534 NUSA K Transcription elongation factor NusA COG0195 Cluster_504875 V1273535 RIMP S Required for maturation of 30S ribosomal subunits (By similarity) COG0779 Cluster_510045 V1273536 map02020 T response regulator COG2197 Cluster_384191 V1273537 NLPD M peptidase M23 COG0739 Cluster_250350 V1273538 FTSX map02010 D Part of the ABC transporter FtsEX involved in COG2177 Cluster_766475 V1273539 S NA 0ZHU9 Cluster_290029 V1273541 LACC map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G tagatose-6-phosphate kinase COG1105 Cluster_127519 V1273544 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_236130 V1273545 LDH map00010,map00270,map00620,map00640,map01100,map01110,map01120 C L-lactate dehydrogenase COG0039 Cluster_348999 V1273548 DEOD map00230,map00240,map00270,map00760,map01100,map01110 F purine nucleoside phosphorylase DeoD-type COG0813 Cluster_447119 V1273549 PSSA map00260,map00564,map01100 I cdpdiacylglycerol-serine O-phosphatidyltransferase COG1183 Cluster_146534 V1273550 SUN J ribosomal RNA small subunit methyltransferase COG0144 Cluster_718439 V1273551 YUGP S zinc metallopeptidase COG2738 Cluster_227797 V1273552 GLPX map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120 G Fructose-1,6-bisphosphatase COG1494 Cluster_431068 V1273554 YKAA P phosphate transport regulator COG1392 Cluster_80984 V1273557 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_89983 V1273558 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0587 Cluster_81355 V1273559 L helicase COG4646 Cluster_191695 V1273561 S Membrane COG0628 Cluster_352135 V1273563 S NA 0XXFU Cluster_162905 V1273565 M Glycosyl transferase (Group 1 0YE5J Cluster_596372 V1273566 RPLL map03010 J Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) COG0222 Cluster_116314 V1273569 U relaxase mobilization nuclease domain protein COG3843 Cluster_625654 V1273570 L hydrolase COG0494 Cluster_205076 V1273571 MUTY map03410 L a g-specific adenine glycosylase COG1194 Cluster_213842 V1273575 S kila-n, DNA-binding domain 0XPNQ Cluster_154481 V1273576 XYLG S ABC transporter COG3845 Cluster_482809 V1273577 T cyclic nucleotide-binding domain protein COG0664 Cluster_482810 V1273578 BL01171 P hemerythrin hhe cation binding domain protein COG2461 Cluster_463165 V1273581 map00230 F Adenylate cyclase COG1437 Cluster_683545 V1273583 S VRR-NUC domain protein 122HE Cluster_296835 V1273587 LGAS_0583 S Replication Protein 0YVZX Cluster_385973 V1273590 S Protein of unknown function (DUF1700) 11XIW Cluster_458980 V1273591 PFLC O Pyruvate formate-lyase COG1180 Cluster_649216 V1273592 PHNA map00440,map01120 P Alkylphosphonate utilization operon protein PhnA COG2824 Cluster_586212 V1273593 PCP O Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) COG2039 Cluster_312306 V1273594 S Rhodanese-like domain 11QSF Cluster_674542 V1273595 NTPG map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG1436 Cluster_419815 V1273597 S pkd domain 0ZXSR Cluster_708629 V1273600 S VRR-NUC domain protein 122HE Cluster_142795 V1273601 S biotin apo-protein ligase-related 11GC5 Cluster_112781 V1273602 RGPF M Rhamnan synthesis protein F COG3754 Cluster_139804 V1273603 BMUL_2277 L DNA Methylase COG1475 Cluster_108821 V1273605 S domain protein 11FI4 Cluster_520588 V1273608 RPIB map00030,map00710,map01100,map01110,map01120,map01230 G isomerase COG0698 Cluster_204001 V1273609 HSDM V type I restriction-modification system COG0286 Cluster_504876 V1273610 P uptake regulation protein COG0735 Cluster_228964 V1273611 map02010 P periplasmic solute binding protein COG0803 Cluster_275116 V1273612 NUSA K Transcription elongation factor NusA COG0195 Cluster_280425 V1273613 V 5-methylcytosine restriction system COG4268 Cluster_560954 V1273614 S NA 0Y6BA Cluster_751745 V1273615 COAA map00770,map01100 H pantothenic acid kinase COG1072 Cluster_329139 V1273616 SP_1381 V abc transporter atp-binding protein COG1131 Cluster_461054 V1273617 S Membrane Fusion Protein 0ZZS9 Cluster_349000 V1273618 YLME F alanine racemase domain protein COG0325 Cluster_357172 V1273621 LYTB map00511 G endo-beta-N-acetylglucosaminidase COG4193 Cluster_360494 V1273622 E, G Membrane COG0697 Cluster_429103 V1273623 S Nitroreductase COG3560 Cluster_520589 V1273624 TOPB L Dna topoisomerase COG0550 Cluster_391224 V1273627 S NA 0XT4D Cluster_377137 V1273628 METI map02010 P ABC transporter, permease COG2011 Cluster_358820 V1273629 CBPA O DnaJ domain protein COG2214 Cluster_629353 V1273630 NSPC map00330 E Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) COG0019 Cluster_416224 V1273631 S Abortive infection protein AbiGI 11WH3 Cluster_560955 V1273632 map00051,map00500,map00520,map01100 G kinase (PfkB family COG0524 Cluster_529000 V1273633 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_403657 V1273635 map02010 P extracellular solute-binding protein COG1840 Cluster_599871 V1273638 GLOB map00620 C Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) COG0491 Cluster_427208 V1273639 LEPB map03060 U Signal peptidase i COG0681 Cluster_159567 V1273641 MDH map00620,map00710,map01100,map01120,map02020 C malate dehydrogenase (Oxaloacetate-decarboxylating) COG0281 Cluster_153669 V1273642 M O-Antigen Polymerase COG3307 Cluster_298233 V1273643 L Site-specific recombinase COG1961 Cluster_103447 V1273644 map02010 V ABC transporter 0XPIZ Cluster_120638 V1273648 CAT map00281,map00620,map00626,map01110,map01120 C Transferase COG0427 Cluster_670148 V1273649 MURE map00300,map00550 M mur ligase COG0769 Cluster_324593 V1273650 COBQ S Glutamine amidotransferase COG3442 Cluster_567130 V1273651 SDPI S Membrane COG5658 Cluster_718440 V1273653 map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_537522 V1273655 S NA 11HX4 Cluster_534629 V1273656 K DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog 11NKX Cluster_300894 V1273657 BCELL_1025 L Integrase COG2801 Cluster_458981 V1273658 CLOSA_1745 L transposase COG2963 Cluster_213843 V1273659 S Pfam:DUF1393 0ZWTR Cluster_121415 V1273660 RNFC C Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) COG4656 Cluster_267035 V1273661 map02010 V Abc transporter COG1132 Cluster_515342 V1273663 S Pyridoxamine 5-phosphate COG5015 Cluster_439075 V1273664 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_487426 V1273665 S NA 0Z34Z Cluster_377138 V1273666 S NA 0Z34Z Cluster_434986 V1273668 INFC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) COG0290 Cluster_389497 V1273669 map00230 F, P ppx gppa phosphatase COG0248 Cluster_106430 V1273670 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_97369 V1273671 GPMI map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0696 Cluster_342588 V1273673 FABH map00061,map01100 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) COG0332 Cluster_480475 V1273674 K Transcriptional regulator COG0583 Cluster_162071 V1273676 METTU_1963 L Transposase 0XRAH Cluster_621860 V1273677 S Prophage pi2 protein 37 11UE0 Cluster_649217 V1273678 S prophage pi2 protein 38 11U3I Cluster_419816 V1273679 S major tail protein, phi13 family 11ICY Cluster_421617 V1273681 FTHC map00670,map01100 H 5-formyltetrahydrofolate cyclo-ligase COG0212 Cluster_758718 V1273682 S abc transporter, permease COG1079 Cluster_183841 V1273683 E Branched-chain amino acid transport system / permease component COG4603 Cluster_499929 V1273686 B, K radical SAM domain protein COG1243 Cluster_211645 V1273687 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_124116 V1273688 LKTB V ABC transporter, ATP-binding protein COG2274 Cluster_683546 V1273689 L helicase COG4646 Cluster_423469 V1273690 S integral membrane protein 11P1U Cluster_347400 V1273691 map02010 P Cobalt transport protein COG0619 Cluster_95721 V1273692 S YD repeat protein 0Z0FY Cluster_398366 V1273693 FRNE Q DSBA oxidoreductase COG2761 Cluster_95722 V1273694 HCP C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) COG1151 Cluster_678970 V1273695 S lipolytic protein G-D-S-L family 0XT5K Cluster_463166 V1273696 MUG map03410 L U mismatch-specific DNA glycosylase COG3663 Cluster_396629 V1273697 T Ser Thr phosphatase family protein COG0639 Cluster_110071 V1273699 S NA 127VK Cluster_349001 V1273700 RECO map03440 L Involved in DNA repair and RecF pathway recombination (By similarity) COG1381 Cluster_352136 V1273701 THIG map00730,map01100 H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) COG2022 Cluster_324594 V1273702 THIH map00730,map01100 H biosynthesis protein thiH COG1060 Cluster_104016 V1273703 CSTA T Carbon starvation protein CstA COG1966 Cluster_96834 V1273704 L helicase COG4646 Cluster_711822 V1273708 CITD map00020,map01110,map02020 C Covalent carrier of the coenzyme of citrate lyase (By similarity) COG3052 Cluster_222003 V1273711 L Dna topoisomerase COG0550 Cluster_751747 V1273713 YIIF S affects formate dehydrogenase-N 17TSZ@proNOG Cluster_554981 V1273714 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_342589 V1273715 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_610744 V1273717 map03430 L dna adenine COG0338 Cluster_267036 V1273718 DPNII V Type II restriction 0YTH4 Cluster_288749 V1273720 NUSA K Transcription elongation factor NusA COG0195 Cluster_502468 V1273721 RIMP S Required for maturation of 30S ribosomal subunits (By similarity) COG0779 Cluster_614468 V1273722 YHAO L DNA repair exonuclease COG0420 Cluster_183842 V1273723 YHAN S domain protein COG4717 Cluster_256483 V1273726 GK0308 L Transposase COG3464 Cluster_185591 V1273727 GEOTH_0192 L Transposase (IS4 family 0ZVQ7 Cluster_678971 V1273728 S NA 0Y4V7 Cluster_177817 V1273729 S NA 11G8Y Cluster_261715 V1273730 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_195321 V1273731 MUTL2 S dna mismatch repair 0XRIS Cluster_141293 V1273732 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_196178 V1273733 THIC map00730,map01100 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) COG0422 Cluster_540312 V1273734 MAMA map00660,map01100 E Glutamate mutase subunit sigma COG2185 Cluster_408918 V1273738 FPRA C domain protein COG0426 Cluster_128207 V1273739 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_169488 V1273742 S Domain of unknown function DUF87 0ZJHN Cluster_238651 V1273744 S copper amine 121X1 Cluster_755216 V1273745 S B3 4 domain protein COG3382 Cluster_456997 V1273746 YYBA K Transcriptional regulator COG1846 Cluster_360495 V1273747 YIHY S ribonuclease BN COG1295 Cluster_321448 V1273748 CPHY_2173 L Transposase 11J2V Cluster_380639 V1273750 TDK map00240,map00983,map01100 F thymidine kinase COG1435 Cluster_416225 V1273751 PRFA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) COG0216 Cluster_721741 V1273752 CITG map02020 H triphosphoribosyl-dephospho-CoA synthase COG1767 Cluster_300895 V1273753 SIGB K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG1191 Cluster_101160 V1273755 S NA 0YZ82 Cluster_195322 V1273756 ARGF map00330,map01100,map01110,map01230 E ornithine carbamoyltransferase COG0078 Cluster_766476 V1273757 AGCS E Sodium:alanine symporter family COG1115 Cluster_226665 V1273758 LKTB3 V ABC transporter, ATP-binding protein COG2274 Cluster_341065 V1273759 YDJZ S SNARE associated Golgi protein-related protein COG0398 Cluster_418025 V1273762 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_350630 V1273763 YUGP S zinc metallopeptidase COG2738 Cluster_205077 V1273764 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120 G phosphohexose isomerase COG0166 Cluster_429104 V1273765 S NA 11KFQ Cluster_275117 V1273766 CCMA V ABC transporter COG1131 Cluster_427209 V1273767 ECFA1 map02010 P abc transporter COG1122 Cluster_373654 V1273768 T Two component transcriptional regulator, winged helix family COG0745 Cluster_312307 V1273769 map02020 T Histidine kinase COG0642 Cluster_773888 V1273770 RSMC J methyltransferase COG2813 Cluster_394848 V1273772 VRAR map02020 T response regulator COG2197 Cluster_326087 V1273773 map02020 T Histidine kinase 11JQW Cluster_318491 V1273774 RIBD map00740,map01100 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) COG1985 Cluster_382417 V1273775 RIBE map00740,map01100 H riboflavin synthase, subunit alpha COG0307 Cluster_285987 V1273776 DAM map03430 L Dna adenine methylase COG0338 Cluster_259098 V1273778 SDAAA map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase COG1760 Cluster_104618 V1273779 M Cell surface protein 11GRZ Cluster_731685 V1273780 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_277753 V1273781 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_168564 V1273783 S transporter gate domain protein 0XRV8 Cluster_434987 V1273784 C oxidoreductase nitrogenase component 1 COG2710 Cluster_156125 V1273785 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_156126 V1273786 YXBA S ATP-grasp COG3919 Cluster_378919 V1273787 SERB map00260,map00680,map01100,map01120,map01230 E phosphoserine phosphatase COG0560 Cluster_497263 V1273788 GLXK map00260,map00561,map00630,map01100,map01110 G Glycerate kinase COG1929 Cluster_109450 V1273789 S phage tail tape measure protein COG5412 Cluster_398367 V1273790 POTD map02010 E ABC transporter COG0687 Cluster_434988 V1273791 THIJ map05012 T DJ-1 family COG0693 Cluster_106431 V1273793 PEPF E Oligoendopeptidase f COG1164 Cluster_480476 V1273794 map02010 P ABC transporter COG1840 Cluster_254040 V1273795 FBPC map02010 E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COG3842 Cluster_107650 V1273797 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_458982 V1273799 IRC4 S Protein of unknown function (DUF1706) COG4283 Cluster_463167 V1273800 L Membrane COG4905 Cluster_557029 V1027202 SCPB K Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) COG1386 Cluster_506693 V1027203 M TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_506694 V1027204 NPDA map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_754195 V1027205 ACPP I Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) COG0236 Cluster_506695 V1027206 YEJB map02010 P Binding-protein-dependent transport systems, inner membrane component COG4174 Cluster_511903 V1027208 MT1814 V Hnh endonuclease 11XHB Cluster_506696 V1027209 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_506697 V1027210 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_624517 V1027214 S NA 0YFTJ Cluster_509315 V1027215 map02010 G extracellular solute-binding protein family 1 COG1653 Cluster_575689 V1027221 GLYQ map00970 J glycyl-tRNA synthetase, alpha subunit COG0752 Cluster_899627 V1027224 map02010 G solute-binding protein COG1653 Cluster_695170 V1027226 PHOH T Phoh family COG1702 Cluster_506700 V1027228 NDVA V ABC superfamily ATP binding cassette transporter COG1132 Cluster_506701 V1027229 MNAA map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_701634 V1027230 YQHA L UPF0114 protein COG2862 Cluster_506702 V1027231 S fad dependent oxidoreductase COG2509 Cluster_704646 V1027232 CZCA P Heavy metal efflux pump, CzcA COG3696 Cluster_509316 V1027235 YDJN S sodium dicarboxylate symporter COG1823 Cluster_698538 V1027238 L Integrase, catalytic region COG2801 Cluster_843201 V1027239 NOCA_0571 L transposase COG2963 Cluster_509317 V1027243 PCNA map03013,map03018 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate COG0617 Cluster_514538 V1027244 BGLB map00010,map00460,map00500,map00940,map01100,map01110 G 6-phospho-beta-glucosidase COG2723 Cluster_509318 V1027247 S S-layer homology domain 11IK1 Cluster_647931 V1027248 ANSA map00250,map00460,map00910,map01100,map01110 E L-asparaginase COG0252 Cluster_506703 V1027249 S baseplate J family protein COG3299 Cluster_647932 V1027251 ACSA map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120 I amp-dependent synthetase and ligase COG0365 Cluster_698539 V1027252 ECTP P Transporter COG1292 Cluster_569272 V1027257 FECE map02010 P ABC transporter, ATP-binding protein COG1120 Cluster_509321 V1027259 RPLQ map03010 J 50S ribosomal protein l17 COG0203 Cluster_631977 V1027260 S Glutathione-dependent formaldehyde-activating Gfa 17EJ0@proNOG Cluster_691203 V1027261 SDAA map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase COG1760 Cluster_588501 V1027262 S NA 17907@proNOG Cluster_506704 V1027263 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_701635 V1027265 SIGC K rna polymerase sigma factor COG1595 Cluster_924598 V1027266 S NA 0XXJW Cluster_847193 V1027269 PBRT P iron permease COG0672 Cluster_509322 V1027270 AAPQ map02010 E amino acid ABC transporter COG4597 Cluster_585236 V1027273 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_704647 V1027274 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_843202 V1027275 HIT F, G Histidine triad (HIT) protein COG0537 Cluster_509323 V1027277 K Transcriptional regulator COG2204 Cluster_609636 V1027279 QOR C Alcohol dehydrogenase zinc-binding domain protein COG0604 Cluster_517262 V1027284 NRDB map00230,map00240,map00480,map01100,map04115 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_509324 V1027285 TRAD U Conjugative transfer protein COG3505 Cluster_511904 V1027289 GLPQ map00564 C glycerophosphoryl diester phosphodiesterase COG4222 Cluster_509327 V1027291 RPSB map03010 J 30S ribosomal protein S2 COG0052 Cluster_560084 V1027292 GLDM S gliding motility-associated protein gldm 0XREI Cluster_511905 V1027298 V FtsX-like permease family 17BAM@proNOG Cluster_647933 V1027299 NIRD map00910,map01120 C nitrite reductase NADPH small subunit COG2146 Cluster_733957 V1027301 TUPA map02010 P ABC transporter COG2998 Cluster_511906 V1027302 ERIC P Chloride channel COG0038 Cluster_511907 V1027305 S Protein of unknown function (DUF2855) 16RW1@proNOG Cluster_511908 V1027306 MOEB map00730,map01100,map04122 H uba thif-type nad fad binding protein COG0476 Cluster_511909 V1027307 XYLC map00622,map00623,map00627,map01100,map01120,map01220 C benzaldehyde dehydrogenase COG1012 Cluster_509328 V1027309 DDH map00300,map01100,map01110,map01230 E Diaminopimelate dehydrogenase 0XPX2 Cluster_509329 V1027313 S Inherit from NOG: domain protein 18D01@proNOG Cluster_640002 V1027314 S NA 11HBJ Cluster_511911 V1027320 GGT map00430,map00460,map00480,map00590,map01100 E Gamma-glutamyltransferase (EC 2.3.2.2) COG0405 Cluster_812265 V1027322 YPEQ S Protein of unknown function (DUF2602) 0XW87 Cluster_525430 V1027323 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_578785 V1027325 M Cell wall binding repeat 2-containing protein COG2247 Cluster_511913 V1027327 G TRAP dicarboxylate transporter-DctP subunit COG1638 Cluster_740709 V1027328 K Ribbon-helix-helix protein, copG family 0Y6D6 Cluster_511914 V1027329 U, W Domain-Containing protein COG5295 Cluster_514539 V1027331 AGCS map02020 E amino acid carrier protein COG1115 Cluster_514540 V1027332 RLMB map00340,map00350,map00624,map01120 J RNA methyltransferase TrmH family group 3 COG0566 Cluster_511916 V1027334 S Ragb susd domain-containing protein 0Y93Q Cluster_511917 V1027335 T EAL 16VDJ@proNOG Cluster_757759 V1027337 SSCG_01041 map00400,map01100,map01110,map01230 E Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) COG1605 Cluster_514541 V1027340 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_578786 V1027343 map02020,map04112 T Diguanylate cyclase 17C7M@proNOG Cluster_631979 V1027344 FUSA2 T elongation factor G COG0480 Cluster_548304 V1027345 S NA 0ZGSE Cluster_528254 V1027346 YHFS E pyridoxal phosphate binding 1756R@proNOG Cluster_511918 V1027347 BL00983 S Phage Portal Protein 11QNG Cluster_643920 V1027348 E amino acid AbC transporter 16TP9@proNOG Cluster_664553 V1027351 S NA 11FFJ Cluster_628209 V1027353 EXBD U Biopolymer transport protein exbD tolR 11TA0 Cluster_511919 V1027354 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_511920 V1027356 T Diguanylate cyclase phosphodiesterase with PAS PAC 16PBJ@proNOG Cluster_514542 V1027357 ASPC map00250,map00290,map01100,map01110,map01210,map01230 E Aminotransferase COG0436 Cluster_875080 V1027359 ZAPA S Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) COG3027 Cluster_682198 V1027360 CVPA S cvpA family COG1286 Cluster_514543 V1027361 MT2607 map00330,map00480,map01100,map01110 E decarboxylase COG1982 Cluster_514544 V1027363 map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map05204 C S-(hydroxymethyl)glutathione dehydrogenase class III alcohol dehydrogenase COG1062 Cluster_727393 V1027364 BMUL_6032 K iclR family transcriptional regulator COG1414 Cluster_920515 V1027366 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_664555 V1027367 S NA 0XWWS Cluster_511921 V1027368 S NA 0YUF4 Cluster_691204 V1027372 S NA 0Y8NN Cluster_701637 V1027375 PKNB T Serine Threonine protein kinase COG2815 Cluster_617014 V1027377 S Nucleoside 2-deoxyribosyltransferase 1CAVQ@tenNOG Cluster_854717 V1027381 NODJ map02010 V ABC-2 type transporter COG0842 Cluster_575690 V1027382 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_514546 V1027383 GGT map00430,map00460,map00480,map00590,map01100 E Gamma-glutamyltranspeptidase (EC 2.3.2.2) COG0405 Cluster_720809 V1027384 S Membrane COG4836 Cluster_514547 V1027386 ILVI map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E Acetolactate synthase large subunit COG0028 Cluster_514548 V1027387 S WD40-like beta Propeller containing protein 0YCAG Cluster_514549 V1027388 S NA 0YB2E Cluster_788419 V1027389 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_514550 V1027390 Y3785 S Uncharacterized protein conserved in bacteria N-term (DUF3322) COG4924 Cluster_514551 V1027391 PEPF E Oligoendopeptidase f COG1164 Cluster_514552 V1027392 S NA 0YHDF Cluster_754197 V1027393 CDD map00240,map00983,map01100,map05219 F cytidine deaminase COG0295 Cluster_631980 V1027394 map00052,map00520,map01100,map01110 G, M epimerase COG0451 Cluster_668887 V1027397 S Inherit from NOG: domain protein 128Z2 Cluster_514553 V1027398 GSHA map00480,map01100 H glutamate--cysteine ligase 16R0G@proNOG Cluster_107651 V1273801 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_135904 V1273802 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_302271 V1273803 map02010 P abc-3 protein COG1108 Cluster_387777 V1273804 GLYQ map00970 J glycyl-tRNA synthetase, alpha subunit COG0752 Cluster_362074 V1273805 RECO map03440 L Involved in DNA repair and RecF pathway recombination (By similarity) COG1381 Cluster_531836 V1273807 map03070,map04626,map05133 M Outer membrane efflux protein COG1538 Cluster_586213 V1273808 LEGAS_1040 L transposase COG2963 Cluster_302272 V1273809 BCELL_1025 L Integrase COG2801 Cluster_109451 V1273810 S DNA repair protein 0XQPN Cluster_247780 V1273811 S Relaxase mobilization nuclease 11PW0 Cluster_283158 V1273812 PIRIN O pirin domain protein COG1741 Cluster_193518 V1273813 XERC2 L Integrase COG0582 Cluster_489770 V1273814 S NA 11U17 Cluster_398368 V1273817 L DNA alkylation repair enzyme COG4912 Cluster_394849 V1273819 HALSA_0542 L Transposase COG2801 Cluster_478075 V1273820 SG1639 S Phage-Associated Protein COG3600 Cluster_300896 V1273821 PARB K parb-like partition protein COG1475 Cluster_326088 V1273822 K Transcriptional regulator 11GAC Cluster_189049 V1273823 MURG map00550,map01100,map04112 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) COG0707 Cluster_529001 V1273825 YEDF map04122 S selenium metabolism protein yedf 11NCC Cluster_909273 V1273826 S NA 179WB@proNOG Cluster_618217 V1273831 S mobilization protein 11J0G Cluster_384192 V1273834 YQFA S hemolysin iii COG1272 Cluster_439076 V1273837 S UPF0597 protein COG3681 Cluster_504877 V1273838 RPLK map03010 J This protein binds directly to 23S ribosomal RNA (By similarity) COG0080 Cluster_352137 V1273839 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_232491 V1273840 PANC map00410,map00770,map01100,map01110 H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) COG0414 Cluster_165363 V1273841 S WD40-like beta Propeller containing protein 0YCAG Cluster_115583 V1273842 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_393034 V1273845 SCRK map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G fructokinase COG1940 Cluster_169489 V1273846 P ABC-type nitrate sulfonate bicarbonate transport COG0715 Cluster_485129 V1273852 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate (By similarity) COG0167 Cluster_368697 V1273853 PYRK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) COG0543 Cluster_607093 V1273855 S NA 102J1 Cluster_118419 V1273856 BFO_0051 L Transposase (IS4 family 11USC Cluster_242577 V1273859 TRXB map00240,map00450 O thioredoxin reductase COG0492 Cluster_741658 V1273860 S NA 11FVN Cluster_303717 V1273861 S plasmid recombination enzyme 0XPM6 Cluster_515343 V1273862 Q Methyltransferase COG0500 Cluster_285988 V1273863 E amino acid ABC transporter, amino acid-binding protein 0YVP9 Cluster_269789 V1273864 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_487427 V1273865 MUTL map03430 L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) COG0323 Cluster_394850 V1273866 DCTP C symporter COG1301 Cluster_380640 V1273867 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_117736 V1273868 L phage plasmid primase, p4 family COG3378 Cluster_728411 V1273871 DINB L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity) COG0389 Cluster_380641 V1273872 E HAD-superfamily subfamily IB hydrolase COG0560 Cluster_145744 V1273874 S S-layer domain protein 12C8X Cluster_433083 V1273875 GLGA map00500,map01100,map01110,map04973 G Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) COG0297 Cluster_425267 V1273876 G 4-alpha-glucanotransferase COG1640 Cluster_625656 V1273881 S NA 0ZHU9 Cluster_136711 V1273882 PRDA map00330 S d-proline reductase 0ZZWY Cluster_418026 V1273883 MANY map00051,map00520,map01100,map02060 G PTS System COG3715 Cluster_327655 V1273884 MANN map00051,map00052,map00520,map01100,map02060 G PTS system mannose fructose sorbose family transporter subunit IID COG3716 Cluster_526238 V1273885 CITC map02020 C (citrate (pro-3S)-lyase ligase COG3053 Cluster_290030 V1273886 CITG map02020 H triphosphoribosyl-dephospho-CoA synthase COG1767 Cluster_260404 V1273887 SPOU J rrna methyltransferase COG0566 Cluster_596374 V1273892 S NA 11NX4 Cluster_131916 V1273893 MIAB J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) COG0621 Cluster_755217 V1273894 RSBV T stage II sporulation protein COG1366 Cluster_201909 V1273895 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_120639 V1273896 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_131147 V1273897 MURD map00471,map00550,map01100 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COG0771 Cluster_350631 V1273898 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_711823 V1273899 CDD map00240,map00983,map01100,map05219 F cytidine deaminase COG0295 Cluster_192624 V1273900 DEGS map02020 O protease COG0265 Cluster_269790 V1273902 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_599872 V1273903 YLXM S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) COG2739 Cluster_213844 V1273906 GPSA map00564 C NADPH-dependent glycerol-3-phosphate dehydrogenase COG0240 Cluster_458983 V1273908 S NA 11XBE Cluster_264390 V1273909 MTNA map00270,map01100 J Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) COG0182 Cluster_876244 V1273913 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_261716 V1273915 SSCG_06117 S degv family COG1307 Cluster_447120 V1273916 M acetyltransferase COG1247 Cluster_389498 V1273917 CUTC P copper homeostasis protein cutc COG3142 Cluster_372035 V1273919 map00270,map00450,map00670,map01100,map01110,map01230 S vitamin B12 dependent methionine synthase activation 11H9C Cluster_375365 V1273920 map00270,map00450,map00670,map01100,map01110,map01230 E Methylenetetrahydrofolate reductase COG0646 Cluster_526239 V1273923 S Phage terminase small subunit COG3747 Cluster_133505 V1273924 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (alpha subunit) COG0587 Cluster_526240 V1273926 ISPE map00900,map01100,map01110 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COG1947 Cluster_142796 V1273927 TNPX L Resolvase COG3505 Cluster_813409 V1273931 L Site-specific recombinase COG1961 Cluster_540313 V1273933 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_261717 V1273935 C Binding Domain protein COG0348 Cluster_596375 V1273937 RNPA J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) 122NB Cluster_294083 V1273938 LOLD V abc transporter atp-binding protein COG1136 Cluster_725091 V1273939 RPSL map03010 J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) COG0048 Cluster_497264 V1273940 RPSG map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) COG0049 Cluster_499930 V1273941 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_206169 V1273942 S Domain-Containing protein 122NA Cluster_534630 V1273943 DPS P Ferritin, Dps family protein COG0783 Cluster_618218 V1273944 LSA_07090 L Transposase COG2963 Cluster_451114 V1273949 E Lysine cadaverine antiporter membrane protein CadB COG0531 Cluster_380642 V1273950 S NA 0XX04 Cluster_167708 V1273951 S Membrane COG0628 Cluster_678973 V1273954 MREB D Rod shape-determining protein mreb COG1077 Cluster_715188 V1273955 METF map00670,map00720,map01100,map01120 E Methylenetetrahydrofolate reductase COG0685 Cluster_579780 V1273956 TRXB map00240,map00450 O Thioredoxin reductase COG0492 Cluster_157847 V1273957 COBW S CobW P47K family protein COG0523 Cluster_557902 V1273959 WECD map00350,map00362,map00627,map00642,map00903,map01120 S -acetyltransferase 11PF0 Cluster_223186 V1273960 DPNA L helicase COG4646 Cluster_275118 V1273961 OPPC map02010 P abc transporter, permease COG1173 Cluster_621861 V1273962 OPPB map02010 P ABC transporter (permease) COG0601 Cluster_836406 V1273964 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_209431 V1273965 M Efflux transporter rnd family, mfp subunit 0ZWAU Cluster_744964 V1273966 RPSP map03010 J 30s ribosomal protein S16 COG0228 Cluster_489771 V1273967 RLMH S Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) COG1576 Cluster_149607 V1273968 S Na H antiporter COG2056 Cluster_449132 V1273969 ACDA map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I Acyl-coA dehydrogenase COG2025 Cluster_353785 V1273970 FPRA C domain protein COG0426 Cluster_130372 V1273971 DPNA L helicase COG4983 Cluster_326089 V1273972 L DNA (cytosine-5-)-methyltransferase COG2189 Cluster_469451 V1273973 S NA 0XWP0 Cluster_318492 V1273974 PPID O Peptidyl-prolyl cis-trans isomerase COG0760 Cluster_178663 V1273975 PROA map00330,map01100,map01230 E Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) COG0014 Cluster_378920 V1273977 S NA 0ZHU9 Cluster_187347 V1273979 S NA 120Q3 Cluster_175368 V1273980 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG2812 Cluster_603472 V1273981 COMEB map00240,map01100 F deaminase COG2131 Cluster_543238 V1273982 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_649218 V1273983 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_489772 V1273984 RPLO map03010 J Binds to the 23S rRNA (By similarity) COG0200 Cluster_801212 V1273985 RPMD map03010 J 50S ribosomal protein L30 0ZI6N Cluster_721744 V1273986 RPSE map03010 J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) COG0098 Cluster_378921 V1273987 S NA 0ZHU9 Cluster_449133 V1273988 YLBN S Nucleic acid-binding protein COG1399 Cluster_363638 V1273989 L DNA alkylation repair enzyme 0YG23 Cluster_434989 V1273990 S radical SAM domain protein COG4277 Cluster_398369 V1273991 P Na Pi-cotransporter COG1283 Cluster_132670 V1273992 S Ragb susd domain-containing protein 0XPPT Cluster_407140 V1273994 GLNP map02010 E amino acid AbC transporter COG0765 Cluster_469452 V1273995 AATB map02010 E ABC transporter substrate-binding protein COG0834 Cluster_781384 V1273996 K acetyltransferase COG0454 Cluster_133506 V1274000 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_441072 V1274001 GSPF map03070 U type ii secretion system COG1459 Cluster_135098 V1274003 TAGE M peptidase M23 COG0739 Cluster_537523 V1274004 map02010,map02020,map05152 P phosphate COG0226 Cluster_273758 V1274005 PSTC map02010 P phosphate abc transporter COG0573 Cluster_373655 V1274008 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG0194 Cluster_162072 V1274009 S NA 11KMZ Cluster_222004 V1274010 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_305229 V1274011 CAS3 L CRISPR-associated helicase, cas3 COG1203 Cluster_529002 V1274012 CASA L crispr-associated protein 0XPA1 Cluster_725092 V1274015 S Signal peptidase (SPase) II 102BU Cluster_309345 V1274016 YLMH J s4 domain protein COG2302 Cluster_265716 V1274017 GLYQ map00970 J glycyl-tRNA synthetase, alpha subunit COG0752 Cluster_135905 V1274018 S NA 0YG6V Cluster_543239 V1274019 T FHA domain 0XUTQ Cluster_419817 V1274020 S Loader and inhibitor of phage G40P 0XZVV Cluster_196991 V1274021 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_281753 V1274022 PBP2B map00550,map01100 M penicillin-binding protein COG0768 Cluster_583020 V1274027 SOJ D Chromosome Partitioning Protein COG1192 Cluster_323010 V1274028 WBYL M Glycosyl transferase, family 2 COG0463 Cluster_711824 V1274030 YAFQ S addiction module toxin, RelE StbE family COG3041 Cluster_872147 V1274031 K Transcriptional regulator, GntR family COG1802 Cluster_649220 V1274033 V ABC transporter COG1132 Cluster_321449 V1274036 L integrase family 0XRS7 Cluster_176975 V1274038 LACG map00052,map01100 G Glycosyl hydrolase family 1 COG2723 Cluster_167709 V1274042 S domain protein 0YF83 Cluster_139805 V1274043 MUTS2 map03430 L muts2 protein COG1193 Cluster_353786 V1274044 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_139806 V1274045 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_202952 V1274046 LDH map00010,map00270,map00620,map00640,map01100,map01110,map01120 C L-lactate dehydrogenase COG0039 Cluster_674544 V1274047 map00190,map00680,map01100 C ATP synthase, subunit F 124BE Cluster_393035 V1274048 map00190,map00680,map01100 C subunit e 0Y1FS Cluster_751749 V1274049 ATPA map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) COG1155 Cluster_385974 V1274050 SOJ D Chromosome Partitioning Protein COG1192 Cluster_492266 V1274051 S NA 0ZPB7 Cluster_546171 V1274052 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_537524 V1274053 ZNTR K Transcriptional regulator COG0789 Cluster_621862 V1274054 H IA, variant 3 COG0637 Cluster_194449 V1274056 MYCA S Myosin-Cross-Reactive Antigen COG4716 Cluster_403658 V1274058 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_471619 V1274059 NWAT_1386 L is1 orf2 COG1662 Cluster_419818 V1274061 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_708631 V1274062 GROS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) COG0234 Cluster_142020 V1274063 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_777574 V1274065 O Thioredoxin COG0526 Cluster_458984 V1274066 J acetyltransferase, (GNAT) family COG1670 Cluster_209432 V1274067 NHAC map00680 C Na H antiporter COG1757 Cluster_492267 V1274068 V N-6 DNA Methylase COG0286 Cluster_687977 V1274069 S NA 0YYBY Cluster_368698 V1274073 M Inherit from COG: YD repeat protein COG3209 Cluster_534631 V1274075 S Protein of unknown function (DUF3021) 0Y7Z2 Cluster_347401 V1274076 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_213845 V1274077 L site-specific recombinase, phage integrase family COG4974 Cluster_142797 V1274078 S ABC transporter, permease 11NJ6 Cluster_478076 V1274080 L Transposase, IS605 OrfB family 0XT7Q Cluster_143489 V1274081 E Family 5 COG0747 Cluster_173741 V1274082 VIRE2 S Virulence-associated protein e COG5545 Cluster_482813 V1274083 FTNA map00860 P ferritin COG1528 Cluster_201910 V1274084 S Relaxase mobilization nuclease 0Y9PG Cluster_143490 V1274085 CSTA T Carbon starvation protein CstA COG1966 Cluster_303718 V1274087 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_518015 V1274088 RIMI O ribosomal-protein-alanine acetyltransferase COG0456 Cluster_194450 V1274089 S peptidase C10 11SDT Cluster_520590 V1274090 Y1855 P asch domain protein COG4405 Cluster_504879 V1274091 GRAE K Transcriptional regulator COG3708 Cluster_318493 V1274092 SCOA map00072,map00280,map00627,map00640,map00650,map01100,map01120,map02020 I CoA-transferase, subunit a COG1788 Cluster_494753 V1274093 SCOB map00072,map00280,map00281,map00626,map00627,map00640,map00650,map01100,map01110,map01120,map02020 I CoA-transferase subunit B COG2057 Cluster_549204 V1274094 S NA 11T3H Cluster_263012 V1274095 DAGK I Diacylglycerol kinase COG1597 Cluster_211646 V1274096 V Peptidase C39 family COG2274 Cluster_552094 V1274097 YHCF K TRANSCRIPTIONAl REGULATOR GntR family COG1725 Cluster_876247 V1274100 S domain protein 0XNZW Cluster_247781 V1274101 S -dicarboxylate symporter COG1823 Cluster_552095 V1274105 VIRD4 map03070 U TraG TraD family protein COG3505 Cluster_497265 V1274106 YOCR P transporter COG0733 Cluster_410760 V1274107 RPSD map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) COG0522 Cluster_167710 V1274110 map00051,map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 G Glycosyl hydrolase family 20 COG3525 Cluster_836407 V1274111 RTCB L RtcB Protein COG1690 Cluster_335115 V1274113 O ADP-ribosylglycohydrolase COG1397 Cluster_146535 V1274114 RRGB M Lpxtg-motif cell wall anchor domain protein 0XSEP Cluster_145746 V1274116 S NA 0YZ82 Cluster_576655 V1274117 FADA map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120 I acetyl-coa acetyltransferase COG0183 Cluster_147317 V1274118 S NA 0Y8K6 Cluster_147318 V1274119 S Inherit from NOG: Tail protein COG5412 Cluster_146536 V1274120 S NA 0YB9V Cluster_699409 V1274121 S Protein of unknown function (DUF721) 0XVBM Cluster_345800 V1274122 F Phosphorylase superfamily COG0775 Cluster_785480 V1274124 map00190,map00680,map01100 C V-type sodium ATP synthase, subunit G 0XZCI Cluster_205078 V1274125 NTPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_176164 V1274127 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_543240 V1274129 S NA 0ZHU9 Cluster_303719 V1274130 S c4-dicarboxylate anaerobic carrier COG1288 Cluster_540314 V1274131 E amidohydrolase COG1473 Cluster_174560 V1274133 G domain protein 11V8D Cluster_499931 V1274135 RNZ map03013 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) COG1234 Cluster_403659 V1274136 map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Phosphoglycerate mutase COG0406 Cluster_149608 V1274137 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_755219 V1274138 MGLA map02010 P ABC transporter COG1129 Cluster_247782 V1274139 MGLB map02010,map02030 G Periplasmic binding protein LacI transcriptional regulator COG1879 Cluster_149609 V1274140 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_288750 V1274141 map00130,map00770,map01100,map01110 S Methyltransferase 0ZVQZ Cluster_407141 V1274143 S B3 4 domain protein COG3382 Cluster_520591 V1274144 S GtrA-like protein COG2246 Cluster_603473 V1274146 S NA 0XWZA Cluster_429105 V1274147 PREMU_0213 L RNA-directed DNA polymerase COG3344 Cluster_781385 V1274148 FRUA map00051,map01100,map02060 G PTS System COG1762 Cluster_150477 V1274149 CSAB M Polysaccharide pyruvyl transferase COG2327 Cluster_251573 V1274151 YBBP S TIGR00159 family COG1624 Cluster_185592 V1274152 S NA 0YD1F Cluster_280426 V1274154 M Cpl-7 lysozyme C-terminal domain protein 11GG1 Cluster_243917 V1274155 T His Kinase A (phospho-acceptor) domain COG2205 Cluster_696136 V1274156 SPAR T response regulator COG0745 Cluster_226666 V1274157 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_702447 V1274158 ECFT map02010 P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) COG0619 Cluster_408919 V1274159 NT5E map00230,map00240,map00630,map00760,map01100,map01110 S Hydrolase COG0546 Cluster_699410 V1274160 S Uncharacterized protein UPF0065 COG3181 Cluster_246532 V1274161 map00860,map01100,map01110 H Uroporphyrinogen decarboxylase 11GIZ Cluster_176165 V1274163 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_175369 V1274165 S metallophosphoesterase COG1408 Cluster_172914 V1274166 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_152072 V1274168 L Inherit from COG: DNA Methylase COG0827 Cluster_785481 V1274170 GPMI map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0696 Cluster_560956 V1274171 P permease COG0628 Cluster_345801 V1274172 S conserved protein UCP033563 COG4198 Cluster_332097 V1274175 L DNA methylase COG2189 Cluster_766478 V1274176 S Transcriptional regulator 11G4D Cluster_296836 V1274177 M Polysaccharide biosynthesis protein COG1087 Cluster_338194 V1274178 MTLD map00040,map00051,map01100 G mannitol-1-phosphate 5-dehydrogenase COG0246 Cluster_153670 V1274179 HPPA map00190 C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for COG3808 Cluster_629355 V1274181 S Protein of unknown function (DUF1312) COG5341 Cluster_467341 V1274182 YNHI map00900,map01110 S heptaprenyl diphosphate synthase component I COG4769 Cluster_165364 V1274183 M Sulfatase COG1368 Cluster_718443 V1274184 map00230 S Metal Dependent Phosphohydrolase 11UWJ Cluster_384193 V1274185 S radical SAM domain protein COG4277 Cluster_531838 V1274187 PBP1B map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_398370 V1274189 PIRIN O pirin domain protein COG1741 Cluster_523329 V1274190 T UspA domain-containing protein COG0589 Cluster_785482 V1274191 ENGB S Necessary for normal cell division and for the maintenance of normal septation (By similarity) COG0218 Cluster_543241 V1274195 S NA 12ATY Cluster_155315 V1274196 C FMN-binding domain protein COG3976 Cluster_380643 V1274197 PLSY map00561,map00564,map01100 S Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) COG0344 Cluster_290031 V1274198 POTB map02010 P ABC transporter, permease COG1176 Cluster_554983 V1274201 S NA 0ZHU9 Cluster_201911 V1274205 HPPA map00190 C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for COG3808 Cluster_824984 V1274206 YCHF J gtp-binding protein COG0012 Cluster_449134 V1274207 OCAR_7462 map00270,map00450,map01100,map01110,map01230 E Methionine synthase COG0620 Cluster_298234 V1274208 L Phage Integrase Family COG0582 Cluster_844370 V1274209 map00362,map00621,map00622,map01100,map01120 S 4-oxalocrotonate tautomerase COG1942 Cluster_344190 V1274210 V Mate efflux family protein COG0534 Cluster_380644 V1274211 NHAP P Potassium proton antiporter COG3263 Cluster_156983 V1274212 S Inherit from NOG: Mediates binding to human platelets, possibly through a receptor-ligand interaction. Probably associated with virulence in endovascular infection (By similarity) 12CMI Cluster_708632 V1274213 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_246533 V1274214 NADE map00760,map01100 H Nad synthetase COG0388 Cluster_708633 V1274215 S Ser Thr phosphatase family protein COG1408 Cluster_179527 V1274217 CKL_1893 S Phage replisome organizer 11V35 Cluster_433084 V1274218 S Phage terminase small subunit 11F23 Cluster_249094 V1274220 RUMAL_0756 S Inherit from NOG: DDE_Tnp_IS1595 0Z8NA Cluster_210513 V1274221 CWLV M n-acetylmuramoyl-l-alanine amidase COG0860 Cluster_394851 V1274223 PARB K parb-like partition protein COG1475 Cluster_250351 V1274224 YPJC S YitT family COG1284 Cluster_224377 V1274225 CYCMA_1561 L Transposase COG3436 Cluster_158710 V1274228 AMD E amidohydrolase COG1473 Cluster_327656 V1274229 VEX3 V abc transporter permease protein COG0577 Cluster_255248 V1274230 MDLA V ABC transporter, ATP-binding protein COG1132 Cluster_570219 V1274232 M Sulfatase COG1368 Cluster_341066 V1274233 RADC L DNA repair protein (RadC COG2003 Cluster_844371 V1274234 MAF D MAF-like protein COG0424 Cluster_263013 V1274235 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_751751 V1274236 WS0013 S membrAne 0XPGN Cluster_220853 V1274242 DNAD L DNA replication protein DnaD COG3935 Cluster_504880 V1274244 S phage protein 0XQDU Cluster_425269 V1274245 S Phage-associated protein 11FS5 Cluster_185593 V1274248 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_207261 V1274250 L Resolvase COG1961 Cluster_162073 V1274256 PPSA S pyruvate phosphate dikinase 0XRDW Cluster_246534 V1274258 M Cell Wall COG5263 Cluster_921758 V1274259 YODJ M carboxy-peptidase COG1876 Cluster_687979 V1274260 YODJ M carboxy-peptidase COG1876 Cluster_162906 V1274261 U TraG family COG3505 Cluster_281754 V1274262 ISPA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_162074 V1274265 CITF map00020,map01110,map02020 C citrate lyase, alpha COG3051 Cluster_515344 V1274266 ADK map00230,map00240,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_781386 V1274267 INFA J however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) COG0361 Cluster_162907 V1274268 M domain protein COG4932 Cluster_734930 V1274270 YIUB map02010 P ABC transporter permease COG0609 Cluster_762533 V1274271 S iron-only hydrogenase system regulator 121PF Cluster_193519 V1274272 YNBB map00260,map00270,map00450,map01100,map01230 P aluminum resistance protein COG4100 Cluster_178664 V1274273 INLJ map05150 M Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps 1215X Cluster_227798 V1274274 S NA 0Z6MD Cluster_487429 V1274276 FTNA map00860 P ferritin COG1528 Cluster_164514 V1274279 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_165365 V1274281 GATC2 map00052,map01100,map02060 G PTS system, galactitol-specific IIc component COG3775 Cluster_809412 V1274282 FOLA map00670,map00790,map01100 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) COG0262 Cluster_319970 V1274283 THYA map00240,map00670,map01100 F Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) COG0207 Cluster_607094 V1274285 YEAO S MarR family Transcriptional regulator COG3189 Cluster_184720 V1274286 BH0416 L Transposase COG3464 Cluster_400089 V1274287 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_412583 V1274288 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_166174 V1274289 S NA 0ZVGZ Cluster_670150 V1274290 L DNA binding domain, excisionase family 11HMG Cluster_649221 V1274291 S NA 11G2G Cluster_480477 V1274292 CCL S Membrane COG4708 Cluster_734931 V1274293 M Inherit from NOG: Gram positive anchor 11HQ6 Cluster_456999 V1274297 L Type III restriction-modification system methylase COG2189 Cluster_191696 V1274298 ADDA L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation COG1074 Cluster_469453 V1274299 ELI_3180 S NA 122AZ Cluster_398371 V1274300 HGDC I coA-substrate-specific enzyme activase COG1924 Cluster_457000 V1274301 HGDA map00362,map01100,map01120,map01220 E dehydratase COG1775 Cluster_257770 V1274302 V ABC transporter, ATP-binding protein COG1132 Cluster_728412 V1274303 map02010 V Abc transporter COG1132 Cluster_828781 V1274305 RPMD map03010 J 50S ribosomal protein L30 129V6 Cluster_469454 V1274306 RPSE map03010 J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) COG0098 Cluster_599873 V1274307 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_275119 V1274308 ATPG map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) COG0224 Cluster_762534 V1274313 PFL C formate acetyltransferase COG1882 Cluster_313802 V1274314 FUMA map00020,map00720,map01100,map01110,map01120 C Hydrolyase, Fe-S type, tartrate fumarate subfamily, alpha subunit COG1951 Cluster_670151 V1274315 S Uncharacterised protein, DegV family COG1307 0YGG8 Cluster_345803 V1274316 L Integrase COG0582 Cluster_419819 V1274319 CTPC map00190 P heavy metal translocating P-type ATPase COG2217 Cluster_226667 V1274322 GATB map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 Cluster_310778 V1274323 YBHK S UPF0052 protein COG0391 Cluster_592900 V1274324 YHBJ S Displays ATPase and GTPase activities (By similarity) COG1660 Cluster_523330 V1274326 C Flavodoxin COG0716 Cluster_711827 V1274327 RPSI map03010 J 30S ribosomal protein S9 COG0103 Cluster_305230 V1274329 YDIA S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) COG1806 Cluster_423470 V1274330 AHPC O C-terminal domain of 1-Cys peroxiredoxin COG0450 Cluster_469455 V1274331 V abc transporter permease protein 0XQE2 Cluster_836409 V1274332 PEPN map00480,map01100 E aminopeptidase N COG0308 Cluster_280427 V1274334 S Inherit from COG: virion core protein (Lumpy skin disease COG4260 Cluster_741660 V1274335 YQFL S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) COG1806 Cluster_207262 V1274336 N, U domain protein COG3942 Cluster_187348 V1274337 BMUL_2277 L DNA Methylase COG1475 Cluster_271101 V1274338 AROE map00400,map01100,map01110,map01230 E shikimate dehydrogenase COG0169 Cluster_172000 V1274339 SSAG_00936 L Transposase 0XNRT Cluster_188205 V1274340 C Hydrogenase large subunit domain protein COG4624 Cluster_172001 V1274341 M Inherit from COG: YD repeat protein COG3209 Cluster_543242 V1274342 STP T phosphatase COG0631 Cluster_294084 V1274344 YABB map00340,map00350,map00624,map01120 L Methyltransferase COG4123 Cluster_333604 V1274345 PHOH T Phoh family COG1702 Cluster_546173 V1274346 YBEY map00240,map00983,map01100 F Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) COG0319 Cluster_797243 V1274348 S NA 11QC5 Cluster_649222 V1274349 S prophage pi2 protein 38 11U3I Cluster_172915 V1274350 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_687981 V1274351 S NA 11T0G Cluster_189917 V1274353 S NA 0YCCW Cluster_219659 V1274354 MEGL map00260,map00270,map00450,map00920,map01100,map01110,map01230 E methionine gamma-lyase COG0626 Cluster_183012 V1274355 CLCAR_0322 D domain protein COG5279 Cluster_172916 V1274356 NDVA2 V ABC transporter, ATP-binding protein COG1132 Cluster_469456 V1274358 S Nitroreductase family 11M4U Cluster_173742 V1274359 map00230,map00240 F 2',3'-cyclic-nucleotide 2'-phosphodiesterase EC 3.1.4.16 COG0737 Cluster_773890 V1274360 T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase COG2972 Cluster_451115 V1274361 SERP0565 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_178665 V1274363 DACET_0688 L Transposase COG3328 Cluster_563935 V1274364 TMK map00240,map01100 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) COG0125 Cluster_661633 V1274365 YAAQ S protein from nitrogen regulatory protein P-II COG3870 Cluster_227800 V1274366 T Histidine kinase 0XNMH Cluster_175370 V1274368 ACTP P p-type ATPase COG2217 Cluster_201912 V1274369 VIRB4 map03070,map05120 U conjugal transfer ATPase COG3451 Cluster_363639 V1274370 K Peptidase S24-like 0XUC3 Cluster_175371 V1274371 RIBBA map00740,map01100 H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) COG0807 Cluster_718444 V1274373 RNHB map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0164 Cluster_492268 V1274375 ETFA map00910 C Electron transfer flavoprotein COG2025 Cluster_307922 V1274376 POTC1 E Binding-protein-dependent transport systems, inner membrane component COG1177 Cluster_290032 V1274377 BLA2 map00311,map00312,map01110,map02020 V Beta-lactamase COG2367 Cluster_670152 V1274378 TUSD map04122 P Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) COG1553 Cluster_607095 V1274379 TUSC map04122 P Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) COG2923 Cluster_702448 V1274380 TUSB map04122 P Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) COG2168 Cluster_211647 V1274381 RFE M Glycosyl transferase, family 4 COG0472 Cluster_277754 V1274382 ASPC map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aminotransferase class I and II COG0436 Cluster_176976 V1274384 S Inherit from NOG: Mediates binding to human platelets, possibly through a receptor-ligand interaction. Probably associated with virulence in endovascular infection (By similarity) 12CMI Cluster_176977 V1274385 GLNN map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG3968 Cluster_239921 V1274386 BCELL_1025 L Integrase COG2801 Cluster_176978 V1274387 V Inherit from COG: Type II restriction enzyme, methylase COG1002 Cluster_232492 V1274388 M Cpl-7 lysozyme C-terminal domain protein 11GG1 Cluster_176979 V1274389 U Type iv secretory pathway vird4 0XSWX Cluster_353787 V1274391 BIOW map00780,map01100 H Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) COG1424 Cluster_291349 V1274392 MGTE P magnesium transporter COG2239 Cluster_187349 V1274393 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_176980 V1274394 M Minor structural protein 0XPF3 Cluster_408920 V1274395 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_455057 V1274396 NRDB map00230,map00240,map00480,map01100,map04115 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_696137 V1274397 OATA I Acyl-transferase COG1835 Cluster_336640 V1274398 S Membrane 0ZTTH Cluster_546174 V1274399 CAFA map03018 J ribonuclease COG1530 Cluster_465247 V1274401 YXBA S ATP-grasp COG3919 Cluster_179528 V1274402 U, W Pfam:Hep_Hag COG5295 Cluster_410761 V1274403 map02020 T response regulator COG2197 Cluster_633193 V1274404 S NA 0YF9C Cluster_421618 V1274405 V T5orf172 0XQ8K Cluster_502469 V1274406 S NA 0ZBGF Cluster_589505 V1274408 C Nitroreductase COG0778 Cluster_180362 V1274413 S NA 101UU Cluster_363640 V1274416 SRTD M Sortase family COG3764 Cluster_316900 V1274417 HUTI map00340,map01100 Q imidazolone-5-propionate hydrolase COG1228 Cluster_921760 V1274418 YBAK S YbaK ebsC protein COG2606 Cluster_362075 V1274420 NUC L nuclease COG1525 Cluster_389499 V1274421 RPLC map03010 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 Cluster_260405 V1274423 YICL E, G Transporter COG0697 Cluster_296837 V1274424 CDR P pyridine nucleotide-disulfide oxidoreductase COG0607 Cluster_183013 V1274425 RECG map03420,map03440 L transcription-repair coupling factor COG1197 Cluster_433085 V1274428 S NA 129D9 Cluster_182109 V1274429 S NA 0YH2T Cluster_817147 V1274430 S F420-0:Gamma-glutamyl ligase 0Y085 Cluster_251574 V1274431 S NA 11T5Y Cluster_307923 V1274432 S Nitroreductase 11QVA Cluster_518016 V1274434 L Inherit from COG: Resolvase COG1961 Cluster_222005 V1274435 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_821022 V1274436 RPSM map03010 J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits COG0099 Cluster_725093 V1274437 BL05010 S ribosomal protein L14e 0XUZY Cluster_721746 V1274438 ADK map00230,map00240,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_805379 V1274439 S ResB-like family 11I08 Cluster_427210 V1274440 L site-specific recombinase, phage integrase family COG0582 Cluster_715189 V1274442 MAF D MAF-like protein COG0424 Cluster_321450 V1274443 LDHA map00260,map00620,map00630,map00680,map01100,map01110,map01120 C Dehydrogenase COG1052 Cluster_583021 V1274444 MANA map00051,map00520,map01100,map01110 G mannose-6-phosphate isomerase COG1940 Cluster_560958 V1274445 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_905201 V1274447 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_357174 V1274448 YJFP S Esterase COG1073 Cluster_363641 V1274449 CRT map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00630,map00640,map00650,map00720,map00903,map00930,map01100,map01110,map01120 I 3-hydroxybutyryl-CoA dehydratase COG1024 Cluster_552096 V1274450 HBD map00360,map00362,map00650,map01100,map01120 I 3-hydroxyacyl-CoA dehydrogenase COG1250 Cluster_257771 V1274451 FTSX map02010 D Part of the ABC transporter FtsEX involved in COG2177 Cluster_637248 V1274452 RPLV map03010 J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) COG0091 Cluster_711828 V1274453 RPSS map03010 J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) COG0185 Cluster_208392 V1274454 PEPS E aminopeptidase COG2309 Cluster_257772 V1274455 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_184721 V1274457 S NA 11NI8 Cluster_345804 V1274458 YQFA S UPF0365 protein COG4864 Cluster_583022 V1274459 NFED O nodulation efficiency protein D COG1030 Cluster_309346 V1274461 K Transcriptional Regulator AraC Family COG5564 Cluster_487430 V1274462 ARCC map00230,map00330,map00910,map01120 E carbamate kinase COG0549 Cluster_692408 V1274463 GLUQ map00860,map00970,map01100,map01110 J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) COG0008 Cluster_184722 V1274465 O Fn3-like domain (DUF1034) COG1404 Cluster_184723 V1274466 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 Cluster_373657 V1274467 RBR C Rubrerythrin COG1592 Cluster_731686 V1274468 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_212733 V1274469 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_375366 V1274471 S single-strand binding family protein 0XS6K Cluster_250352 V1274472 BH0416 L Transposase COG3464 Cluster_449135 V1274473 map00040,map00051,map01100 G xylose isomerase COG4952 Cluster_453042 V1274474 map02060 G pts system COG1264 Cluster_276447 V1274475 S phage-like element pbsx protein xkdK 0ZVHW Cluster_323011 V1274477 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_781388 V1274479 map00230 S Metal Dependent Phosphohydrolase 11UWJ Cluster_421619 V1274480 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_492269 V1274481 RPSD map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) COG0522 Cluster_398372 V1274483 CDSA map00564,map01100,map04070 I Phosphatidate cytidylyltransferase COG0575 Cluster_378922 V1274484 S tail tape measure protein COG5280 Cluster_288751 V1274487 YWCJ P Formate nitrite transporter COG2116 Cluster_515345 V1274488 K Transcriptional regulator COG0583 Cluster_515346 V1274489 SCOB map00072,map00280,map00281,map00626,map00627,map00640,map00650,map01100,map01110,map01120,map02020 I CoA-transferase subunit B COG2057 Cluster_228965 V1274490 COMD map02020 T Histidine kinase COG2972 Cluster_223187 V1274493 OPPA map02010 E Extracellular solute-binding protein, family 5 COG4166 Cluster_645118 V1274494 S NA 0ZHU9 Cluster_360496 V1274495 FTSK D cell division protein FtsK COG1674 Cluster_560959 V1274496 RIMO J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) COG0621 Cluster_357175 V1274497 GLGB map00500,map01100,map01110 G 1,4-alpha-glucan branching enzyme COG0296 Cluster_445058 V1274499 SP_0859 S Membrane COG3817 Cluster_549205 V1274500 S NA 0YIEB Cluster_321451 V1274501 CBBZ map00630,map01100,map01110 S Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) COG0546 Cluster_485130 V1274503 YTSP T gaf domain protein COG1956 Cluster_785483 V1274504 S NA 0YI1D Cluster_310779 V1274505 S NA 0YEUF Cluster_226668 V1274506 APBE H ApbE family COG1477 Cluster_393036 V1274508 YCHF J gtp-binding protein COG0012 Cluster_515347 V1274509 YIDI S Inner membrane protein YidI 17U0Q@proNOG Cluster_478077 V1274510 S NA 0ZDT4 Cluster_425270 V1274511 HTPG map04141,map04151,map04612,map04621,map04626,map04914,map04915,map05200,map05215 O Molecular chaperone. Has ATPase activity (By similarity) COG0326 Cluster_433086 V1274512 PGN_0055 S NA 11YX6 Cluster_200923 V1274515 XDHA map00230,map01100,map01120 C Xanthine dehydrogenase COG1529 Cluster_189918 V1274516 ADE map00230,map01100 F adenine deaminase COG1001 Cluster_190768 V1274517 map03440 K Inherit from bactNOG: transcriptional regulator COG2865 Cluster_283159 V1274519 L Integrase COG0582 Cluster_758721 V1274520 GFO_1229 L Integrase COG0582 Cluster_296838 V1274521 ECFT map02010 P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) COG0619 Cluster_233746 V1274522 RLUC J Pseudouridine synthase COG0564 Cluster_457001 V1274523 S NA 0YIHX Cluster_702449 V1274524 T cyclic nucleotide-binding domain protein COG0664 Cluster_401869 V1274525 BL01171 P hemerythrin hhe cation binding domain protein COG2461 Cluster_349002 V1274526 S Multi-copper polyphenol oxidoreductase laccase COG1496 Cluster_365381 V1274528 ISPA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_192625 V1274529 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_859893 V1274530 S NA 0XV0D Cluster_407142 V1274531 S NA 0ZVGZ Cluster_416226 V1274535 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_868151 V1274537 S NA 0Y54I Cluster_824987 V1274538 S NA 0XYW6 Cluster_303720 V1274539 GUFA P Mediates zinc uptake. May also transport other divalent cations (By similarity) COG0428 Cluster_385975 V1274540 RPSD map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) COG0522 Cluster_396632 V1274541 K GntR family transcriptional regulator COG2188 Cluster_738264 V1274542 SMPB O Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) COG0691 Cluster_257773 V1274543 BMUR_1332 S Domain of Unknown Function (DUF1599) 0XXR0 Cluster_599874 V1274544 METTU_0245 L is1 orf2 COG1662 Cluster_394852 V1274546 L DNA primase 11GUV Cluster_687982 V1274549 ARSR K Transcriptional regulator, arsR family COG0640 Cluster_554984 V1274550 ARSC T Protein-tyrosine phosphatase, low molecular weight COG0394 Cluster_543243 V1274551 C Flavodoxin COG0716 Cluster_678974 V1274553 SPOU map00340,map00350,map00624,map01120 J tRNA rRNA methyltransferase (SpoU) COG0566 Cluster_194451 V1274554 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_378923 V1274555 YIFK E amino acid COG1113 Cluster_272430 V1274559 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_345805 V1274560 map02020 S Membrane COG3333 Cluster_194452 V1274562 LEVR K Transcriptional COG3933 Cluster_864189 V1274563 PURB map00230,map00250,map01100,map01110 F adenylosuccinate lyase COG0015 Cluster_649223 V1274564 S NA 0Y10N Cluster_489773 V1274565 DSY2934 L Transposase 1012J Cluster_358821 V1274566 BPET1060 L DNA polymerase COG3344 Cluster_618220 V1274567 S NA 0Y4VN Cluster_809413 V1274568 S NA 11XG1 Cluster_480478 V1274569 S Sigma-70, region 4 1194K Cluster_195325 V1274570 RNFC C Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) COG4656 Cluster_292696 V1274573 ASPA map00250,map00910,map01100 E Aspartate ammonia-lyase COG1027 Cluster_195326 V1274575 V ABC transporter COG1132 Cluster_557903 V1274576 P ABC transporter (Permease COG0601 Cluster_377140 V1274577 APPC P ABC transporter permease COG1173 Cluster_552098 V1274578 RPSL map03010 J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) COG0048 Cluster_657432 V1274580 O peptidylprolyl cis-trans isomerase COG0545 Cluster_264391 V1274581 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_234931 V1274582 S m50 family 11QC0 Cluster_275120 V1274583 XYNB I esterase COG0657 Cluster_207263 V1274584 PARE L DNA topoisomerase IV (Subunit B) COG0187 Cluster_213846 V1274585 GLGD map00500,map00520,map01100,map01110 M glucose-1-phosphate adenylyltransferase, glgd subunit COG0448 Cluster_196992 V1274586 CPDA F serine threonine protein phosphatase COG1409 Cluster_398373 V1274587 K Transcriptional regulator, LacI family COG1609 Cluster_625659 V1274588 RBSK map00030 G ribokinase COG0524 Cluster_209433 V1274591 PYC map00020,map00620,map00720,map01100,map01120,map01230 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) COG1038 Cluster_469457 V1274592 RPSE map03010 J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) COG0098 Cluster_844372 V1274593 RPMD map03010 J 50S ribosomal protein L30 COG1841 Cluster_306607 V1274594 PSTC map02010 P phosphate abc transporter COG0573 Cluster_741661 V1274595 PSTA map02010 P phosphate abc transporter COG0581 Cluster_228966 V1274596 S NA 0YG6V Cluster_226669 V1274597 S Acyl-transferase 128XF Cluster_407143 V1274598 S NA 11SZV Cluster_407144 V1274599 KAMA map00310 E lysine 2,3-aminomutase COG1509 Cluster_744965 V1274600 TRXB map00240,map00450 O thioredoxin reductase COG0492 Cluster_218506 V1274602 SPEB S peptidase C10 11SDT Cluster_741662 V1274605 VICX map03013 S domain protein COG1235 Cluster_649224 V1274607 E amidohydrolase COG1473 Cluster_492270 V1274609 NIMB S Resistance protein COG3467 Cluster_198932 V1274610 S Inherit from COG: virion core protein (Lumpy skin disease COG4260 Cluster_210514 V1274611 G Transketolase, C-terminal domain COG0021 Cluster_199927 V1274612 S radical SAM domain protein COG0535 Cluster_427211 V1274613 SP_0496 P Na Pi-cotransporter COG1283 Cluster_621864 V1274614 NRDG O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) COG0602 Cluster_263014 V1274616 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_389500 V1274617 YAGU S Inner membrane protein yagU COG3477 Cluster_852055 V1274619 YKGJ S Ferredoxin COG0727 Cluster_576656 V1274621 S NA 11ZC4 Cluster_531839 V1274623 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_781389 V1274624 RPMC map03010 J 50s ribosomal protein l29 COG0255 Cluster_738265 V1274625 RPSQ map03010 J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal COG0186 Cluster_504881 V1274626 map04112 L dna modification methylase COG0863 Cluster_425271 V1274627 S Conjugative transposon TraM protein 11JMY Cluster_447122 V1274628 RAIA J ribosomal subunit Interface protein COG1544 Cluster_200924 V1274629 S NA 0ZYTH Cluster_200925 V1274630 IADA S Isoaspartyl dipeptidase 0XNTK Cluster_327657 V1274631 S LemA family COG1704 Cluster_579781 V1274633 LDH map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120 C L-Lactate dehydrogenase COG0039 Cluster_797244 V1274635 CRO K HTH_XRE 0XYF7 Cluster_398374 V1274636 LIN1243 S domain protein COG1235 Cluster_408921 V1274638 CUTS map00633,map00680,map00720,map01120 C domain protein COG2080 Cluster_543244 V1274639 XDHB map00230,map00633,map00680,map00720,map01100,map01120 C Dehydrogenase COG1319 Cluster_201913 V1274640 M Sulfatase COG1368 Cluster_201914 V1274641 GLVC map00010,map02060 G PTS System COG1264 Cluster_576657 V1274642 BL02553 K Transcriptional regulator COG1959 Cluster_557904 V1274644 S Protein of unknown function (DUF2752) 12CMJ Cluster_641241 V1274645 K helix-turn-helix domain-containing protein 11J2A Cluster_557905 V1274646 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_599876 V1274647 S PASTA 0ZKZ3 Cluster_201915 V1274648 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_336641 V1274649 S s-layer domain-containing protein 11ZJU Cluster_201916 V1274650 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_416227 V1274652 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_777578 V1274653 SECE map03060,map03070 U Preprotein translocase SecE subunit 0XUXP Cluster_299498 V1274654 ISPG map00900,map01100,map01110 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) COG0821 Cluster_603474 V1274655 OGT L Methyltransferase COG0350 Cluster_549206 V1274656 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_250353 V1274658 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_711829 V1274660 C radical SAM domain protein COG1032 Cluster_234932 V1274662 HSDM V Type I restriction-modification system, M subunit COG0286 Cluster_603475 V1274663 ISPD map00900,map01100,map01110 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COG1211 Cluster_220854 V1274664 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_280428 V1274665 OPPB1 P Binding-protein-dependent transport systems inner membrane component COG0601 Cluster_247784 V1274666 S NA 101UU Cluster_554985 V1274667 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0847 Cluster_205079 V1274669 YHCD map05133 M usher protein( 16QS5@proNOG Cluster_649225 V1274670 GRDA C In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination 11JMA Cluster_265717 V1274672 ENC_18990 map02060 G IIc component COG1455 Cluster_207264 V1274676 S ATP GTP-binding protein 0Y0B5 Cluster_741663 V1274677 map02010 P ABC transporter COG1122 Cluster_357176 V1274678 map02010 P Cobalt transport protein COG0619 Cluster_207265 V1274680 V abc transporter permease protein 0ZW5X Cluster_657433 V1274681 RPSH map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) COG0096 Cluster_443070 V1274682 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_207266 V1274684 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_273759 V1274685 SRTB U sortase, SrtB family COG4509 Cluster_239922 V1274686 S relaxase mobilization nuclease domain protein 0XNXG Cluster_554986 V1274687 K TRANSCRIPTIONAl REGULATOR GntR family COG1725 Cluster_315376 V1274688 HGDC I coA-substrate-specific enzyme activase COG1924 Cluster_208394 V1274690 S Exporters of the RND superfamily COG1033 Cluster_465248 V1274691 YNHI map00900,map01110 S heptaprenyl diphosphate synthase component I COG4769 Cluster_576658 V1274692 S Protein of unknown function (DUF1292) 1248N Cluster_543245 V1274693 S NA 121S9 Cluster_208395 V1274694 S Bacteriophage peptidoglycan hydrolase 124AI Cluster_252792 V1274695 G domain protein 11V8D Cluster_674547 V1274696 HFQ map03018 T RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) COG1923 Cluster_209434 V1274697 map02010 E Extracellular solute-binding protein, family 5 COG0747 Cluster_210515 V1274698 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_391225 V1274699 YHCA O Periplasmic chaperone protein 178N6@proNOG Cluster_224378 V1274701 NIST map02010 V ABC transporter 0XPIZ Cluster_457002 V1274702 S NA 0XWEM Cluster_797245 V1274703 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_455058 V1274704 YGJV S Membrane 177U6@proNOG Cluster_210516 V1274706 UMUC L ImpB MucB SamB family protein COG0389 Cluster_210517 V1274707 DACA map00550,map01100 M carboxypeptidase COG1686 Cluster_465249 V1274708 S NA 11KVS Cluster_210518 V1274711 OATA I Acyl-transferase COG1835 Cluster_403661 V1274712 MTNA map00270,map01100 J Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) COG0182 Cluster_567131 V1274713 FUCA map00051 G Class II aldolase adducin family protein COG0235 Cluster_215035 V1274715 YCEG F aminodeoxychorismate lyase COG1559 Cluster_210519 V1274716 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_211648 V1274717 S NA 0YCCW Cluster_243918 V1274718 T Pasta domain containing protein COG2815 Cluster_353788 V1274720 MHPT G major facilitator superfamily COG0477 Cluster_256484 V1274721 GSID map02010 P ABC transporter (Permease COG1173 Cluster_212734 V1274722 S Immunoreactive 84 kDa antigen 0Y0NA Cluster_589508 V1274723 ASP S alkaline shock protein COG1302 Cluster_212735 V1274724 S Membrane COG4194 Cluster_455059 V1274726 DUSB J Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_220855 V1274727 HSDS V Type I restriction modification DNA specificity domain COG0732 Cluster_213847 V1274728 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_494754 V1274729 THIJ map05012 T DJ-1 family COG0693 Cluster_457003 V1274730 PROC map00330,map01100,map01110,map01230 E pyrroline-5-carboxylate reductase COG0345 Cluster_215036 V1274733 LYTR K TRANSCRIPTIONal COG1316 Cluster_353789 V1274736 TRAA map03440 L mobA MobL family protein COG0507 Cluster_499932 V1274738 TRML map04122 J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) COG0219 Cluster_526242 V1274739 map00630,map01100,map01110 S haloacid dehalogenase-like hydrolase COG0546 Cluster_333605 V1274740 YDJY S iron-sulfur cluster binding 100DI Cluster_310780 V1274742 YBBM S ABC transporter, permease COG0390 Cluster_766480 V1274743 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_482814 V1274744 RECX S regulatory protein RecX 11Y5X Cluster_276448 V1274746 PAP L polyphosphate kinase 2 COG2326 Cluster_243919 V1274748 P TrkA-N domain protein COG1226 Cluster_219660 V1274749 FUSA2 J Translation elongation factor COG0480 Cluster_347402 V1274750 GAP map00010,map01100,map01110,map01120,map01230,map04066,map05010 G glyceraldehyde-3-phosphate dehydrogenase COG0057 Cluster_257775 V1274752 POTA map02010 E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COG3842 Cluster_263015 V1274753 PGCA map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_738266 V1274754 RUVC map03440 L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) COG0817 Cluster_412584 V1274755 K Transcriptional regulator COG0583 Cluster_502470 V1274757 SLGD_00064 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_465250 V1274758 map02010 P Cobalt transport protein COG0619 Cluster_393037 V1274760 S Toprim domain protein 0XSQN Cluster_603476 V1274761 S NA 0XS4I Cluster_751753 V1274762 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_329140 V1274763 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_583024 V1274767 S NA 0ZHU9 Cluster_315377 V1274768 PRE S plasmid recombination enzyme 0XTDI Cluster_896573 V1274769 O, U Peptidase, S49 COG0616 Cluster_218507 V1274770 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 Cluster_291350 V1274771 S NA 11VT6 Cluster_218508 V1274772 DNAD L DNA replication protein DnaD COG3935 Cluster_821023 V1274773 PTS-EIID map00051,map00520,map01100,map02060 G PTS System COG3716 Cluster_557906 V1274774 map00051,map00520,map01100,map02060 G PTS system fructose IIA component COG2893 Cluster_734933 V1274776 L DNA packaging protein 123DA Cluster_219661 V1274777 M Inherit from COG: YD repeat protein COG3209 Cluster_218509 V1274778 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_645119 V1274779 S NA 11US1 Cluster_352138 V1274781 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_219662 V1274782 V Type III COG3587 Cluster_370402 V1274784 L Resolvase COG1961 Cluster_324595 V1274785 S abc transporter permease protein 124X7 Cluster_219663 V1274786 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_645120 V1274787 DSBA O Thiol disulfide Interchange Protein COG0526 Cluster_705554 V1274788 PURA map00230,map00250,map01100 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis COG0104 Cluster_407145 V1274789 S Uncharacterised protein, DegV family COG1307 0YGG8 Cluster_421621 V1274792 LEMA S LemA family COG1704 Cluster_341067 V1274793 DCUR map02020 T transcriptional regulatory protein COG4565 Cluster_220856 V1274794 BTUB P Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) COG4206 Cluster_699411 V1274795 S Pfam:UPF0027 COG1690 Cluster_437060 V1274796 THID map00730,map00750,map01100 H phosphomethylpyrimidine kinase COG0351 Cluster_455060 V1274798 map00230,map00240,map01100,map03030,map03430,map03440 L exonuclease rnase t and DNA polymerase iii 0Y256 Cluster_412585 V1274800 L Transposase, IS605 OrfB family 0XT7Q Cluster_840336 V1274801 NPDA map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_295484 V1274802 S CAAX protease self-immunity 0XUJM Cluster_344191 V1274803 KBL map00260,map00780,map01100 H 2-amino-3-ketobutyrate coenzyme A ligase COG0156 Cluster_434990 V1274804 MOBB H Molybdopterin-guanine dinucleotide biosynthesis protein b COG1763 Cluster_353790 V1274806 HOLA map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii, delta' subunit COG1466 Cluster_367073 V1274810 K Transcriptional regulator, TetR family COG1309 Cluster_222006 V1274811 V ABC transporter COG1132 Cluster_370403 V1274812 MGTC S MgtC SapB transporter COG1285 Cluster_403662 V1274815 NPDA map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_563936 V1274816 PSTS map02010,map02020,map05152 P phosphate COG0226 Cluster_618221 V1274817 S NA 0YGKT Cluster_423471 V1274818 TRAA map03440 L mobA MobL family protein COG0507 Cluster_375367 V1274819 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_728415 V1274820 FBA map00010,map00030,map00051,map00562,map00680,map00710,map01100,map01110,map01120,map01230 G aldolase COG0191 Cluster_751754 V1274822 PUCG map00250,map00260,map00630,map00680,map01100,map01110,map01120,map04146 E Aminotransferase COG0075 Cluster_813413 V1274825 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_223188 V1274827 V restriction enzyme COG1002 Cluster_410762 V1274829 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_592901 V1274830 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_645122 V1274831 YLBM S UPF0348 protein COG1323 Cluster_443071 V1274832 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_224379 V1274834 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_224380 V1274835 N repeat protein 11QCF Cluster_225547 V1274836 S Iron transport-associated domain protein 0Y3IT Cluster_734934 V1274837 ENGB S Necessary for normal cell division and for the maintenance of normal septation (By similarity) COG0218 Cluster_335116 V1274838 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_260406 V1274840 F HDc COG0232 Cluster_225548 V1274843 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_225549 V1274844 S ABC transporter, permease 11NJ6 Cluster_226670 V1274845 PHRB L deoxyribo-dipyrimidine photolyase COG0415 Cluster_373658 V1274846 YQGA S Membrane COG1811 Cluster_445059 V1274848 FTSX map02010 D Part of the ABC transporter FtsEX involved in cellular division (By similarity) COG2177 Cluster_261718 V1274849 ISPG map00900,map01100,map01110 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) COG0821 Cluster_596376 V1274850 S NA 12C6G Cluster_687983 V1274851 S NA 11T0G Cluster_773891 V1274852 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_441073 V1274853 RPLJ map03010 J 50s ribosomal protein L10 COG0244 Cluster_226671 V1274854 PARC L DNA topoisomerase IV, subunit A COG0188 Cluster_645123 V1274855 DIVIC S septum formation initiator 0XUCI Cluster_552099 V1274856 YABR J RNA binding s1 domain protein COG1098 Cluster_504882 V1274858 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_226672 V1274859 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_463168 V1274860 RACD map00250,map01054 E aspartate racemase COG1794 Cluster_510046 V1274861 YXBA S ATP-grasp COG3919 Cluster_621865 V1274863 K Transcriptional regulator (XRE family 11K4T Cluster_357177 V1274864 V abc transporter permease protein COG0577 Cluster_570221 V1274866 YBEY map00240,map00983,map01100 F Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) COG0319 Cluster_227801 V1274867 M Putative cell wall binding repeat 2 COG5492 Cluster_458985 V1274868 map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG2176 Cluster_563937 V1274869 DDL map00473,map00520,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_227802 V1274871 S NA 0XPJ6 Cluster_316901 V1274872 S NA 0YCKF Cluster_227803 V1274874 YCJV map02010 G Abc transporter COG3839 Cluster_275121 V1274875 YDCC L transposase COG5433 Cluster_665845 V1274877 P Sodium:neurotransmitter symporter family COG0733 Cluster_284533 V1274878 SUFB O FeS assembly protein SUFB COG0719 Cluster_705556 V1274880 S Signal transduction histidine kinase, lyts 11GMZ Cluster_228967 V1274881 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_365382 V1274882 S NA 0XWFB Cluster_499933 V1274883 CBRB S Inner membrane protein yieI 17SZ1@proNOG Cluster_670154 V1274884 S Hydrolase COG0637 Cluster_418028 V1274885 CYDC map02010 V ABC transporter COG4988 Cluster_579782 V1274886 map02010 V ABC transporter, ATP-binding protein COG1132 Cluster_396633 V1274887 CMK map00240,map00410,map00770,map01100,map01110 F Cytidine monophosphate kinase COG0283 Cluster_305231 V1274888 PARB K parb-like partition protein COG1475 Cluster_387778 V1274889 RPLY map03010 J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) COG1825 Cluster_316902 V1274890 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_228968 V1274892 NAGZ map00460,map00500,map00520,map00940,map01100,map01110 G Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) COG1472 Cluster_777579 V1274893 P Heavy-metal-associated domain COG2217 Cluster_657434 V1274894 YBJQ S UPF0145 protein COG0393 Cluster_748310 V1274895 MODF map02010 P ABC transporter COG1119 Cluster_230136 V1274896 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_257776 V1274898 BAS2305 G Major Facilitator superfamily COG0477 Cluster_793273 V1274899 T Two component transcriptional regulator, winged helix family COG0745 Cluster_793274 V1274900 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_665846 V1274901 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_231310 V1274902 GATA map00970,map01100 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) COG0154 Cluster_231311 V1274903 RARA L recombination factor protein RarA COG2256 Cluster_641242 V1274905 S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) COG0599 Cluster_751756 V1274906 RPSA map00900,map01100,map01110,map03010 J 30S ribosomal protein S1 COG0539 Cluster_252793 V1274907 map00040,map01100 G dehydratase COG2721 Cluster_232493 V1274908 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_232494 V1274909 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_269791 V1274910 map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01230 G Fructose-bisphosphate aldolase class-II COG0191 Cluster_412586 V1274912 S Cell surface protein 0ZXQA Cluster_231312 V1274913 DACA map00550,map01100 M carboxypeptidase COG1686 Cluster_445060 V1274914 S NA 0ZNAH Cluster_789485 V1274917 RUVA map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) COG0632 Cluster_333606 V1274919 K anti-repressor COG3645 Cluster_232495 V1274920 S NA 0YH2T Cluster_557907 V1274921 SP_0256 K acetyltransferase, (GNAT) family COG0454 Cluster_453044 V1274922 DPPD map02010 E, P (ABC) transporter COG0444 Cluster_233747 V1274923 PFOR S Membrane COG3641 Cluster_254041 V1274924 M Cna protein B-type domain COG4932 Cluster_233748 V1274925 P TonB-dependent receptor Plug 0XP8A Cluster_801215 V1274927 YAAA S S4 domain protein YaaA COG2501 Cluster_372036 V1274928 CMK map00240,map00410,map00770,map01100,map01110 F Cytidine monophosphate kinase COG0283 Cluster_234933 V1274931 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_789486 V1274932 S RNA-binding S4 domain protein COG2501 Cluster_288752 V1274933 K LysR family Transcriptional regulator 11KMP Cluster_938693 V1274934 S NA 125HR Cluster_458986 V1274935 ARD V Phosphotransferase 11IKQ Cluster_319971 V1274936 S NA 0Z7KY Cluster_696138 V1274938 YICS S Uncharacterized protein YicS 17I1R@proNOG Cluster_443072 V1274939 NEPI G Major Facilitator superfamily COG2814 Cluster_347403 V1274940 E POLIIIAc COG1387 Cluster_234934 V1274941 META map00270,map00920,map01100,map01110,map01230 E Homoserine O-transsuccinylase COG1897 Cluster_510047 V1274942 map00270,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01230 E Aminotransferase class i COG1448 Cluster_641243 V1274943 GROS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) COG0234 Cluster_273761 V1274944 AMD E amidohydrolase COG1473 Cluster_499934 V1274945 S Phage terminase small subunit 11F23 Cluster_288753 V1274947 L Integrase COG0582 Cluster_296839 V1274948 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_461056 V1274949 YLBN S metal-binding protein COG1399 Cluster_523331 V1274950 S NA 11QQ0 Cluster_429107 V1274951 MGTE P magnesium transporter COG2239 Cluster_469458 V1274952 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_567132 V1274953 SRTB U sortase, SrtB family COG4509 Cluster_526243 V1274954 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_434991 V1274955 EFP J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) COG0231 Cluster_342590 V1274956 STP T Phosphatase COG0631 Cluster_236131 V1274959 CTPC map00190 P heavy metal translocating p-type ATPase COG2217 Cluster_494755 V1274962 S NA 0Y4PF Cluster_762535 V1274963 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_463169 V1274964 S Acetyltransferase (GNAT) family 11Z04 Cluster_721748 V1274965 S NA 0ZFWW Cluster_284534 V1274966 RBSC-1 S ABC transporter (Permease COG4603 Cluster_362076 V1274967 Q Methyltransferase COG0500 Cluster_670155 V1274969 YQXD S UPF0178 protein COG1671 Cluster_482815 V1274970 ASPC map00250,map00290,map01100,map01110,map01210,map01230 E Aminotransferase COG0436 Cluster_445061 V1274971 YAAA L UPF0246 protein COG3022 Cluster_576659 V1274972 BCP O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG1225 Cluster_247785 V1274973 RUMA map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_267040 V1274975 ILVC map00290,map00770,map01100,map01110,map01210,map01230 E Alpha-keto-beta-hydroxylacyl reductoisomerase COG0059 Cluster_478078 V1274976 BPET1060 L DNA polymerase COG3344 Cluster_607096 V1274977 S conjugation system ATPase, TraG family 0XSHU Cluster_238652 V1274978 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_394853 V1274979 L Inherit from NOG: transposase 11VUP Cluster_549208 V1274983 CKL_1904 S YopX protein 0XUQJ Cluster_629356 V1274985 YIGG S Inner membrane protein YigG 182RD@proNOG Cluster_583025 V1274986 YIGF S Membrane 17PHS@proNOG Cluster_510048 V1274990 S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) COG0599 Cluster_403664 V1274991 GLGB map00500,map01100,map01110 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) COG0296 Cluster_629357 V1274992 UDK map00240,map00710,map00983,map01100,map01120 F uridine monophosphokinase COG0572 Cluster_344192 V1274993 L DNA methylase COG2189 Cluster_603477 V1274994 L Replication initiator protein A 0Y2JJ Cluster_633194 V1274995 map00540,map01100 S Phage-related protein 11PAV Cluster_238653 V1274996 CINA H competence damage-inducible protein COG1546 Cluster_239924 V1274997 S NA 0YH2T Cluster_755224 V1274998 S NA 0XYB0 Cluster_259099 V1274999 map00190,map00680,map01100 C ATP synthase alpha/beta chain, C terminal domain COG1155 Cluster_407146 V1275000 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_766482 V1275001 G Peptidoglycan-binding LysM COG1388 Cluster_239925 V1275002 MDLA V ABC transporter, ATP-binding protein COG1132 Cluster_738268 V1275003 S NurA domain protein 11IQE Cluster_239926 V1275005 GLUP G transporter COG0738 Cluster_239927 V1275006 GLTA map00250,map00910,map01100,map01110,map01120,map01230 E Glutamate synthase COG0543 Cluster_241204 V1275007 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_259100 V1275008 S Secreted protein 0XRGW Cluster_523332 V1275009 L Inherit from COG: transposase COG1943 Cluster_657435 V1275010 S domain protein 0ZZY0 Cluster_241205 V1275012 HYDG map00730,map01100 H biosynthesis protein thiH COG1060 Cluster_375368 V1275013 V abc transporter permease protein COG0577 Cluster_828782 V1275014 V Mate efflux family protein COG0534 Cluster_332098 V1275015 S aaa ATPase COG3910 Cluster_339616 V1275016 M Inherit from COG: YD repeat protein COG3209 Cluster_242578 V1275017 S NA 101UU Cluster_518019 V1275018 T UspA domain-containing protein COG0589 Cluster_241206 V1275019 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_247786 V1275020 MGLC map02010 G transporter COG4211 Cluster_434992 V1275021 I o-antigen acetylase COG1835 Cluster_705557 V1275022 GLDA map00561,map01100 C glycerol dehydrogenase COG0371 Cluster_625661 V1275023 CARD K Transcriptional regulator (CarD family COG1329 Cluster_683549 V1275024 S lysozyme 0YC6U Cluster_242579 V1275025 S NA 101UU Cluster_279103 V1275027 FUCI map00051 G Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) COG2407 Cluster_478079 V1275028 DUSA J Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_434993 V1275029 UMUC L Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) COG0389 Cluster_368699 V1275031 T response regulator COG0745 Cluster_665847 V1275032 PEPD E Dipeptidase COG4690 Cluster_670156 V1275033 S Tat pathway signal sequence domain protein 0XPAW Cluster_546176 V1275034 S NA 0XY8M Cluster_487431 V1275035 S NA 0YCGG Cluster_360497 V1275036 YUGP S zinc metallopeptidase COG2738 Cluster_272431 V1275038 SPEA map00330,map01100 E Catalyzes the biosynthesis of agmatine from arginine (By similarity) COG1166 Cluster_242580 V1275039 PORA map00020,map00720,map01100,map01120 C Pyruvate flavodoxin ferredoxin oxidoreductase domain protein COG1014 Cluster_469460 V1275040 S Domain of unknown function DUF87 0ZJHN Cluster_534633 V1275041 S NurA domain protein 11IQE Cluster_249095 V1275044 DGT map00230 F deoxyguanosinetriphosphate triphosphohydrolase-like protein COG0232 Cluster_469461 V1275045 YDIB S ATP-binding protein COG0802 Cluster_465251 V1275047 YQJG O Glutathione S-transferase COG0435 Cluster_465252 V1275048 S copper amine 0XP8R Cluster_243920 V1275050 ADDB L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination COG3857 Cluster_291351 V1275051 RFBD map00521,map00523,map01100,map01110 M Dtdp-4-dehydrorhamnose reductase COG1091 Cluster_245189 V1275052 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_277755 V1275054 YIIG S frv operon regulatory protein 17B01@proNOG Cluster_728416 V1275055 L Inherit from COG: Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) COG0389 Cluster_307924 V1275056 KORB map00020,map00720,map01100,map01120 C 2-oxoglutarate ferredoxin oxidoreductase subunit beta COG1013 Cluster_252794 V1275057 S NA 11GQ4 Cluster_281755 V1275060 ACRE V efflux transporter, rnd family, mfp subunit 16Q8Z@proNOG Cluster_260407 V1275062 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_245190 V1275063 LTAE map00260,map01100,map01110,map01120,map01230 E Aldolase COG2008 Cluster_401870 V1275064 RIBU S Membrane COG3601 Cluster_245191 V1275065 HEMZ map00860,map01100,map01110 H coproporphyrinogen III oxidase COG0635 Cluster_342591 V1275066 LDTA S ErfK YbiS YcfS YnhG COG1376 Cluster_465253 V1275067 PGPA map00564,map01100 I phosphatidylglycerophosphatase a COG1267 Cluster_247787 V1275069 CTPC map00190 P heavy metal translocating P-type ATPase COG2217 Cluster_246535 V1275070 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0587 Cluster_410763 V1275072 RRGB M Lpxtg-motif cell wall anchor domain protein 0XSEP Cluster_246536 V1275073 ETFA map00910 C Electron transfer flavoprotein COG2025 Cluster_246537 V1275074 YEII map00240 G kinase (PfkB family COG0524 Cluster_247788 V1275077 map00680 C Na H antiporter COG1757 Cluster_389501 V1275078 LGT M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 Cluster_423472 V1275079 YVOA K (GntR family) (Transcriptional regulator COG2188 Cluster_338195 V1275080 S UPF0597 protein COG3681 Cluster_307925 V1275081 L site-specific recombinase, phage integrase family 0ZF8H Cluster_261719 V1275082 S NA 0Z6MD Cluster_687985 V1275083 COBB map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_373659 V1275085 T Transcriptional regulator, luxr family 0Y5RQ Cluster_273762 V1275086 L DNA polymerase COG3359 Cluster_250354 V1275087 M YD repeat protein COG3209 Cluster_265718 V1275089 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_250355 V1275090 YAET M outer membrane protein assembly complex, YaeT protein COG4775 Cluster_273763 V1275091 UGPE map02010 P ABC transporter COG0395 Cluster_279104 V1275092 S NA 0XQX2 Cluster_250356 V1275095 YAPC M, U outer membrane autotransporter barrel COG3468 Cluster_583026 V1275096 GGT map00430,map00460,map00480,map00590,map01100 E Gamma-glutamyltransferase (EC 2.3.2.2) COG0405 Cluster_777580 V1275098 HPPA map00190 C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for COG3808 Cluster_414447 V1275100 RECR map03440 L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) COG0353 Cluster_250357 V1275101 L Inherit from COG: DNA Methylase COG0827 Cluster_327658 V1275102 ORF028 S NA 0ZZ9R Cluster_583027 V1275103 ATPB map00190,map00195,map01100 C it plays a direct role in the translocation of protons across the membrane (By similarity) COG0356 Cluster_734935 V1275104 ATPE map00190,map00195,map01100 C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) 0ZX31 Cluster_610745 V1275106 map01040 E lipolytic protein G-D-S-L family COG2755 Cluster_504883 V1275107 MSCS M mechanosensitive ion channel COG0668 Cluster_453045 V1275109 MSC_0232 L transposase protein A 11X8W Cluster_674549 V1275110 RPLX map03010 J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) COG0198 Cluster_250358 V1275111 S Rib/alpha-like repeat 10008 Cluster_251576 V1275115 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E brancheD-chain amino acid aminotransferase COG0115 Cluster_728417 V1275116 K, T Peptidase M56 COG4219 Cluster_678978 V1275117 K Transcriptional regulator COG3682 Cluster_560960 V1275118 PYRE map00240,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_252795 V1275123 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_586214 V1275126 S NA 0ZW2I Cluster_252796 V1275127 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_252797 V1275128 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_267041 V1275130 K transcriptional regulator, IclR family COG1414 Cluster_523333 V1275132 SP_0161 K, T lytTr DNA-binding domain protein COG3279 Cluster_254042 V1275134 E amidohydrolase COG1473 Cluster_283160 V1275135 ATPB map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) COG1156 Cluster_414448 V1275136 S Metal Dependent Phosphohydrolase COG2316 Cluster_345806 V1275137 RLUB J Pseudouridine synthase COG1187 Cluster_797246 V1275138 SCPB K Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) COG1386 Cluster_781394 V1275140 CICA E HAD-superfamily subfamily IB hydrolase COG0560 Cluster_254043 V1275142 ATPB map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) COG1156 Cluster_267042 V1275143 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_254044 V1275144 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_255250 V1275146 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_264392 V1275147 M Inherit from COG: YD repeat protein COG3209 Cluster_702451 V1275148 L site-specific recombinase, phage integrase family 0ZF8H Cluster_487432 V1275150 O DnaJ domain protein COG0484 Cluster_633195 V1275151 XFP map00030,map00680,map00710,map01100,map01120 G Phosphoketolase COG3957 Cluster_290033 V1275153 S P-loop domain protein 0XQDB Cluster_445062 V1275154 M Cell wall anchor domain protein 129AF Cluster_352139 V1275155 VIRR map02020 T response regulator COG3279 Cluster_355467 V1275157 S NA 0Y91I Cluster_499935 V1275159 D Cobyrinic acid ac-diamide synthase COG1192 Cluster_573448 V1275160 map02010 V ABC transporter, ATP-binding protein COG1132 Cluster_347404 V1275161 LDTA S ErfK YbiS YcfS YnhG COG1376 Cluster_347405 V1275162 SSCG_06117 S degv family COG1307 Cluster_255251 V1275163 LYTR K TRANSCRIPTIONal COG1316 Cluster_378924 V1275165 map00030,map00040,map00710,map01100,map01110,map01120,map01230 G ribulose-phosphate 3-epimerase COG0036 Cluster_255252 V1275166 DSBD O Thiol disulfide interchange protein COG4232 Cluster_276449 V1275167 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_261720 V1275168 S Putative cell wall binding repeat 0YEGX Cluster_864193 V1275169 S Bacterial SH3 domain 0ZPAA Cluster_353791 V1275170 GLDA map00561,map01100 C glycerol dehydrogenase COG0371 Cluster_292697 V1275171 M peptidase M23 COG0739 Cluster_589509 V1275172 NFO map03410 L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) COG0648 Cluster_465254 V1275173 CYSE map00270,map00920,map01100,map01120,map01230 E serine acetyltransferase COG1045 Cluster_302273 V1275174 YBIR P transporter COG0471 Cluster_540316 V1275176 L NUDIX hydrolase COG0494 Cluster_256485 V1275177 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_725094 V1275178 AAEX S membrane protein AaeX 17KB7@proNOG Cluster_393038 V1275179 PUNA map00230,map00240,map00760,map01100,map01110 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) COG0005 Cluster_257777 V1275180 S Ricin-type beta-trefoil lectin domain 124S7 Cluster_257778 V1275181 S PglZ domain protein 0XQ4Q Cluster_469462 V1275182 S Transcription termination antitermination factor NusG 0YUUM Cluster_288754 V1275183 S NA 11HZH Cluster_257779 V1275185 P TonB-dependent Receptor Plug 0XNNV Cluster_408922 V1275186 YABB map00340,map00350,map00624,map01120 L Methyltransferase COG4123 Cluster_678979 V1275187 RSMI G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 Cluster_336642 V1275188 DING map00230,map00240,map01100,map03030,map03430,map03440 L helicase COG2176 Cluster_345807 V1275189 DHAK map00561,map00680,map01100,map01120,map04622 G Dihydroxyacetone kinase COG2376 Cluster_257780 V1275191 HSDM V Type I restriction-modification system, M subunit COG0286 Cluster_329141 V1275195 HYDG map00730,map01100 H biosynthesis protein thiH COG1060 Cluster_306609 V1275196 E Family 5 COG0747 Cluster_285989 V1275198 BCSB M Cellulose synthase regulator protein 16QAU@proNOG Cluster_259101 V1275199 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_353792 V1275200 T response regulator COG0745 Cluster_259102 V1275201 LSA S (ABC) transporter COG0488 Cluster_389502 V1275202 YIDX S replicase EC 2.7 17QZ0@proNOG Cluster_259103 V1275203 OCAR_6158 L Terminase, large subunit COG4626 Cluster_259104 V1275204 RECQ2 map03018 L ATP-dependent DNA helicase RecQ COG0514 Cluster_629358 V1275205 CTPA M protease COG0793 Cluster_621866 V1275206 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_347406 V1275208 HTRA map03010 M peptidase S1 and S6, chymotrypsin Hap COG0265 Cluster_678980 V1275210 SFUM_1163 map00620,map00640,map00643,map01100,map01120 I CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) COG4670 Cluster_384194 V1275211 S CAAX amino terminal protease family protein 0XUJM Cluster_377142 V1275213 CSHA map03018 L atp-dependent rna helicase COG0513 Cluster_586215 V1275214 S Inherit from COG: virion core protein (Lumpy skin disease COG4260 Cluster_592903 V1275215 YDJG S Zinc finger domain 0XNNM Cluster_813415 V1275216 map02010 P Cobalt transport protein COG0619 Cluster_349003 V1275217 map02010 P ABC transporter COG1122 Cluster_793277 V1275218 S NA 125TX Cluster_260408 V1275220 GLNP E Abc transporter COG0834 Cluster_579783 V1275222 SP_1000 O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG0526 Cluster_721749 V1275223 S NA 11VTP Cluster_777582 V1275224 S NA 0Y39F Cluster_296840 V1275225 S phage Tail Protein 0Z1N7 Cluster_261721 V1275226 PEAH map02010 V ABC transporter, ATP-binding permease protein COG1132 Cluster_260409 V1275228 map00040,map01100 G dehydratase COG2721 Cluster_433087 V1275229 T His Kinase A (phospho-acceptor) domain COG2205 Cluster_300897 V1275230 ATP2C1 P p-type ATPase COG0474 Cluster_316903 V1275233 LDTA S ErfK YbiS YcfS YnhG COG1376 Cluster_261722 V1275234 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_534634 V1275235 S NA 0Z3CK Cluster_319972 V1275238 S Periplasmic binding protein COG3181 Cluster_349004 V1275240 YAAA L UPF0246 protein COG3022 Cluster_828783 V1275241 SBCD L SbcCD D subunit COG0420 Cluster_414449 V1275243 S NA 122W5 Cluster_499936 V1275246 CAS4 L crispr-associated protein Cas4 COG1468 Cluster_573449 V1275247 CAS1 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) COG1518 Cluster_828784 V1275248 YBEY map00240,map00983,map01100 F Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) COG0319 Cluster_389503 V1275249 GOR map00480 C reductase COG1249 Cluster_400090 V1275251 HOM E saf domain-containing protein COG4091 Cluster_302274 V1275254 C Hydrogenase large subunit domain protein COG4624 Cluster_461057 V1275256 V Eco57I restriction endonuclease COG0827 Cluster_583028 V1275257 V T5orf172 0XQ8K Cluster_275122 V1275258 YULF G oxidoreductase COG0673 Cluster_323012 V1275260 FRDB map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120 C succinate dehydrogenase fumarate reductase iron-sulfur subunit COG0479 Cluster_276450 V1275263 S Radical SAM 128D5 Cluster_443074 V1275266 RLMC map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) COG2265 Cluster_529003 V1275267 S NA 12BYI Cluster_507453 V1275269 BPR_I0156 L transposase COG1943 Cluster_665848 V1275270 OPPF map02010 E oligopeptide ABC transporter, ATP-binding protein COG4608 Cluster_629359 V1275271 CZRA K Transcriptional regulator, arsr family COG0640 Cluster_766483 V1275272 O Glutaredoxin COG0695 Cluster_288755 V1275273 TAUC map02010 P Binding-protein-dependent transport systems, inner membrane component COG0600 Cluster_338196 V1275275 S copper amine 121X1 Cluster_265719 V1275276 PYRC map00240,map01100 F dihydroorotase COG0044 Cluster_265720 V1275277 BAPKO_0207 P CBS domain protein COG1253 Cluster_373660 V1275278 VORB map00020,map00280,map00720,map01100,map01120 C Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg COG0674 Cluster_781395 V1275279 VORA map00020,map00280,map00720,map01100,map01120 C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein COG1013 Cluster_445063 V1275280 RNMV L Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) COG1658 Cluster_265721 V1275281 AMAA map00360 E Peptidase dimerisation domain COG1473 Cluster_268448 V1275283 O Peptidase, M16 COG0612 Cluster_629360 V1275284 S Addiction module antitoxin, RelB DinJ family 0XUTM Cluster_661634 V1275286 map03070 U Type iv secretory pathway COG3702 Cluster_552100 V1275287 VIRB4 map03070,map05120 U conjugal transfer ATPase COG3451 Cluster_265722 V1275288 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_265723 V1275289 EGYY_05010 U traE protein COG3451 Cluster_267043 V1275291 PBUG S Xanthine uracil vitamin C permease COG2252 Cluster_358822 V1275293 PATM map02010 E ABC transporter COG0765 Cluster_828785 V1275294 ARTM map02010 E abc transporter atp-binding protein COG1126 Cluster_576660 V1275296 FADE map00071,map00281,map00930,map01100,map01110,map01120 I acyl-Coa dehydrogenase COG1960 Cluster_398375 V1275299 S NA 0XQYE Cluster_728418 V1275300 map00240,map00450 O Pyridine nucleotide-disulphide oxidoreductase COG0492 Cluster_445064 V1275301 IFCA map00020,map00190,map00623,map00650,map00720,map00984,map01100,map01110,map01120,map02020 C Flavocytochrome c COG1053 Cluster_645124 V1275302 RPOZ map00230,map00240,map01100,map03020 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) COG1758 Cluster_296841 V1275303 DNAG map03030 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 Cluster_497267 V1275304 SPOIVFB S Peptidase M50 COG1994 Cluster_268449 V1275305 map00564,map00730 C fad dependent oxidoreductase COG0579 Cluster_268450 V1275306 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_347407 V1275307 DCUA map02020 O Anaerobic c4-dicarboxylate transporter COG2704 Cluster_398376 V1275308 S radical SAM domain protein COG0535 Cluster_414450 V1275309 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_447123 V1275310 COBL map00860,map01100 H Precorrin-6y C5,15-methyltransferase COG2242 Cluster_844374 V1275312 CRT map00630,map00650,map00720,map01120 I enoyl-CoA hydratase COG1024 Cluster_360499 V1275313 SCOA map00072,map00280,map00627,map00640,map00650,map01100,map01120,map02020 I CoA-transferase, subunit a COG1788 Cluster_269792 V1275314 map02010 P ABC superfamily ATP binding cassette transporter COG1122 Cluster_653303 V1275315 E amino acid COG0531 Cluster_451117 V1275316 LCD map00270,map00450,map00920,map01100,map01110,map01230 E Aminotransferase class I and II COG1168 Cluster_377143 V1275318 EPTC S Phosphoethanolamine transferase COG2194 Cluster_269793 V1275319 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_394855 V1275320 YGFC K Transcriptional regulator 120E9 Cluster_269794 V1275321 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_269795 V1275322 S 5-bromo-4-chloroindolyl phosphate hydrolysis protein 111JX Cluster_271102 V1275323 map02010 V ABC transporter 0XPIZ Cluster_755226 V1275324 GREB K Transcription elongation factor GreB COG0782 Cluster_357179 V1275326 S copper amine 121X1 Cluster_592904 V1275327 CAS5E L crispr-associated protein 11JEJ Cluster_809416 V1275329 S Protein of unknown function (DUF2645) 18BV8@proNOG Cluster_665849 V1275330 YJEN S NA 1829F@proNOG Cluster_678981 V1275331 YJEM E Inner membrane transporter yjeM 174IZ@proNOG Cluster_292698 V1275333 map05100 G s-layer domain protein 11IBF Cluster_324596 V1275334 GLTA map00020,map00630,map00640,map01100,map01110,map01120,map01210,map01230 C citrate synthase COG0372 Cluster_394856 V1275337 map00260,map00290,map01100,map01110,map01230 E threonine COG1171 Cluster_357180 V1275338 S Domain of Unknown Function (DUF349) 0ZWN8 Cluster_272432 V1275340 U TraG family COG3505 Cluster_290034 V1275341 LPDA map00010,map00020,map00260,map00280,map00620,map01100,map01110,map01120 C dihydrolipoyl dehydrogenase COG1249 Cluster_285990 V1275342 S NA 0Z34Z Cluster_563939 V1275343 CZCD P cation diffusion facilitator family transporter COG0053 Cluster_492272 V1275345 FUSA2 J Translation elongation factor COG0480 Cluster_592905 V1275346 GLGB map00500,map01100,map01110 G 1,4-alpha-glucan branching enzyme COG0296 Cluster_272433 V1275347 S alpha-2-macroglobulin COG2373 Cluster_272434 V1275349 M efflux transporter, outer membrane factor lipoprotein, NodT family COG1538 Cluster_653304 V1275350 K HTH_XRE 0XU1P Cluster_485131 V1275351 YEHB map05133 M outer membrane usher protein COG3188 Cluster_416228 V1275352 YFCE S Phosphodiesterase COG0622 Cluster_567133 V1275353 TNP L transposase COG1943 Cluster_273764 V1275354 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_353793 V1275355 PEPQ map00310,map00780,map01100 E peptidase M24 COG0006 Cluster_515348 V1275356 TRKA P potassium transporter peripheral membrane COG0569 Cluster_621867 V1275357 TRKH P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) COG0168 Cluster_272435 V1275358 NUOD map00190,map00910,map01100 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) COG0649 Cluster_758723 V1275359 K DNA-binding helix-turn-helix protein 11XIQ Cluster_439077 V1275360 S Toxin-antitoxin system, toxin component 0XRRU Cluster_272436 V1275361 AMET_0853 S NA 17B67@proNOG Cluster_437061 V1275362 HEMN map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_653305 V1275363 S Acetyltransferase GNAT Family 124QK Cluster_766484 V1275365 K Transcriptional regulator 11GAC Cluster_540317 V1275366 S NA 0YRPX Cluster_329142 V1275367 THYX map00240,map00670 F Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) COG1351 Cluster_592906 V1275368 LYTS map02020 T Histidine kinase COG3275 Cluster_610746 V1275370 YJHA S Endonuclease Exonuclease phosphatase 0XNVA Cluster_332099 V1275371 ECFA1 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_275123 V1275372 GALM map00010,map01110,map01120 G converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) COG2017 Cluster_384195 V1275373 GLTA map00020,map00630,map00640,map01100,map01110,map01120,map01210,map01230 C citrate synthase COG0372 Cluster_321452 V1275375 GRDD S fatty acid phospholipid synthesis protein plsX 0XQ1G Cluster_291352 V1275376 G Xylose isomerase domain protein TIM barrel 173RY@proNOG Cluster_273765 V1275377 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_275124 V1275378 SURB S G5 domain protein 0ZVV3 Cluster_900919 V1275379 ARSB P arsenical pump membrane protein COG1055 Cluster_614470 V1275380 ARSR K Transcriptional regulator, arsr family COG0640 Cluster_319973 V1275381 PCRA map03420,map03430 L Atp-dependent dna helicase COG0210 Cluster_273766 V1275382 PACL2 map04260,map04911,map04960,map04961,map04964,map04970,map04971,map04972,map04973,map04974,map04976,map04978 P ATPase, P-type (transporting), HAD superfamily, subfamily IC COG0474 Cluster_363642 V1275383 ASA_0160 L IS630 family transposase COG3335 Cluster_789488 V1275385 K Transcriptional regulator COG3655 Cluster_275125 V1275386 S ABC transporter COG3845 Cluster_549209 V1275388 E, G of the drug metabolite transporter COG0697 Cluster_876255 V1275389 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_275126 V1275390 HPPA map00190 C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for COG3808 Cluster_275127 V1275391 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_275128 V1275395 S tail tape measure protein, TP901 family 0Y9J8 Cluster_276451 V1275396 P tonB-dependent Receptor COG4771 Cluster_482816 V1275397 FBPA K Fibronectin-binding protein COG1293 Cluster_445065 V1275400 S Signal transduction histidine kinase, lyts 11GMZ Cluster_276453 V1275401 S NA 101UU Cluster_431069 V1275404 GLVC map00010,map02060 G PTS System COG1264 Cluster_699413 V1275405 AGLB map00010,map00500 G glycoside hydrolase family 4 COG1486 Cluster_373661 V1275407 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_570223 V1275409 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_467343 V1275410 S NA 0Y86B Cluster_277756 V1275414 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_342592 V1275415 COAA map00770,map01100 H pantothenic acid kinase COG1072 Cluster_277757 V1275416 M YD repeat protein COG3209 Cluster_429109 V1275418 NLPD M peptidase M23 COG0739 Cluster_447124 V1275419 RIBA map00740,map01100 H Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) COG0807 Cluster_350633 V1275421 YEIH S Membrane COG2855 Cluster_531841 V1275423 YQEJ S NA 17E4S@proNOG Cluster_560961 V1275424 S RelA SpoT domain protein COG2357 Cluster_531842 V1275425 S SNARE-like domain protein 0XUKY Cluster_377144 V1275427 GLUA map02010 E abc transporter atp-binding protein COG1126 Cluster_762536 V1275430 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_507454 V1275434 FUR P Ferric uptake COG0735 Cluster_339617 V1275436 TAGG map02010 G, M permease protein COG1682 Cluster_280429 V1275437 FUSA2 T elongation factor g COG0480 Cluster_645125 V1275438 TRXA O Thioredoxin COG0526 Cluster_494757 V1275439 TRXB map00240,map00450 O thioredoxin reductase COG0492 Cluster_347408 V1275440 S NA 11X85 Cluster_280431 V1275447 P Outer membrane protein probably involved in nutrient binding 0XNNV Cluster_410764 V1275448 CBIQ map02010 P Cobalt transport protein COG0619 Cluster_738270 V1275449 CBIO map02010 P ABc transporter ATP-binding protein COG1122 Cluster_537525 V1275451 ASPA map00250,map00910,map01100 E Aspartate ammonia-lyase COG1027 Cluster_281756 V1275452 RNY S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 Cluster_641244 V1275454 CSHA map03018 L atp-dependent rna helicase COG0513 Cluster_487434 V1275455 L Recombinase COG1961 Cluster_280432 V1275456 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_280433 V1275457 L helicase COG4646 Cluster_384196 V1275459 L DNA alkylation repair enzyme COG4912 Cluster_537526 V1275460 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_629361 V1275461 DPPA E Peptidase M55 D-aminopeptidase COG2362 Cluster_280434 V1275462 GGT map00430,map00460,map00480,map00590,map01100 E gamma-glutamyltransferase COG0405 Cluster_281757 V1275463 DNAQ map03022,map03420 L helicase COG1199 Cluster_625662 V1275464 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_389504 V1275465 SSUC map02010 P Binding-protein-dependent transport systems, inner membrane component COG0600 Cluster_363643 V1275466 RDGB map00230,map00240,map01100 F Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) COG0127 Cluster_281758 V1275467 map02010 V ABC transporter transmembrane region COG1132 Cluster_300899 V1275468 O Peptidyl-prolyl cis-trans isomerase 0XT59 Cluster_285991 V1275470 ATPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_283162 V1275471 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_480479 V1275473 SCLAV_0613 S Pfam:DUF151 COG1259 Cluster_305233 V1275474 CYAA map00230,map05111 F Adenylate cyclase COG3072 Cluster_360500 V1275476 M (sortase) family COG3764 Cluster_391226 V1275477 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_396634 V1275479 NDVA2 V ABC transporter, ATP-binding protein COG1132 Cluster_284535 V1275481 M Cna protein B-type domain COG4932 Cluster_485132 V1275483 YACP J Tetracycline resistance protein COG3688 Cluster_287388 V1275484 S Relaxase mobilization nuclease 11PW0 Cluster_284536 V1275485 map00310,map00780,map01100 O peptidase, M16 COG0612 Cluster_287389 V1275486 GSHA map00480,map01100 H glutamate--cysteine ligase COG3572 Cluster_283163 V1275487 S NA 0Z34Z Cluster_410765 V1275488 AGRB map02020 T Essential for the production of a quorum sensing system signal molecule, the autoinducing peptide (AIP). This quorum sensing system is responsible for the regulation of the expression of virulence factor genes. Involved in the proteolytic processing of AgrD, the precursor of AIP (By similarity) COG4512 Cluster_284537 V1275489 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_330551 V1275490 MBL D Rod shape-determining protein mreb COG1077 Cluster_284539 V1275495 N Cell surface protein 1CAVF@tenNOG Cluster_876256 V1275496 CLOSA_1745 L transposase COG2963 Cluster_370404 V1275497 BCELL_1025 L Integrase COG2801 Cluster_284540 V1275498 METE map00270,map00450,map01100,map01110,map01230 E Methionine synthase COG0620 Cluster_573451 V1275499 S NA 0ZHU9 Cluster_284541 V1275503 HOM map00260,map00270,map00300,map01100,map01110,map01120,map01230 E homoserine dehydrogenase COG0460 Cluster_350634 V1275505 S Membrane COG1811 Cluster_319974 V1275506 M Inherit from COG: YD repeat protein COG3209 Cluster_781397 V1275507 S Abortive infection phage resistance protein 0YGER Cluster_285993 V1275508 YXCA I coA-substrate-specific enzyme activase COG3581 Cluster_285994 V1275509 NUSA K Transcription elongation factor NusA COG0195 Cluster_355468 V1275511 SDAAB map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase, iron-sulfur-dependent, beta subunit COG1760 Cluster_441074 V1275512 S NA 0Z7KY Cluster_554987 V1275513 P domain protein COG0607 Cluster_705560 V1275514 MSCS M mechanosensitive ion channel COG0668 Cluster_341069 V1275516 HLYX P Domain of unknown function DUF21 COG1253 Cluster_852058 V1275518 RUBR C rubredoxin COG1773 Cluster_287390 V1275520 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_699414 V1275522 RPMA map03010 J 50S ribosomal protein l27 COG0211 Cluster_852059 V1275524 RPLU map03010 J This protein binds to 23S rRNA in the presence of protein L20 (By similarity) COG0261 Cluster_287391 V1275525 S NA 101UU Cluster_766485 V1275526 RPLC map03010 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 Cluster_670157 V1275527 RPSJ map03010 J Involved in the binding of tRNA to the ribosomes (By similarity) COG0051 Cluster_287393 V1275529 CSPA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_702454 V1275530 YGHW S Protein of unknown function (DUF2623) 17ES4@proNOG Cluster_339618 V1275531 BGLB map00010 G glycoside hydrolase family 1 COG2723 Cluster_738271 V1275534 S Protein of unknown function (DUF3343) 0XTWJ Cluster_592907 V1275535 S NA 1278K Cluster_721750 V1275537 V type I restriction-modification system COG0732 Cluster_290035 V1275538 M phosphoglycerol transferase COG1368 Cluster_797248 V1275540 BMUL_2113 S Pfam:DUF88 COG1432 Cluster_419820 V1275541 GLXR map00280,map00630,map01100 I 2-hydroxy-3-oxopropionate reductase COG2084 Cluster_840341 V1275542 S UPF0597 protein COG3681 Cluster_387779 V1275543 S c4-dicarboxylate anaerobic carrier COG1288 Cluster_699416 V1275544 MTAD F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) COG0402 Cluster_463170 V1275545 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_332100 V1275546 AATB map02010 E ABC transporter substrate-binding protein 0XQ2S Cluster_504884 V1275547 P cation diffusion facilitator family transporter COG0053 Cluster_473712 V1275549 S NA 0ZHU9 Cluster_365383 V1275551 S atp-dependent nuclease subunit 11HAW Cluster_290036 V1275553 M Polysaccharide Biosynthesis Protein COG2244 Cluster_312308 V1275554 S relaxase Mobilization nuclease 0YE2V Cluster_291353 V1275558 M outer membrane autotransporter barrel domain protein COG3468 Cluster_290037 V1275559 MCRB V ATPase associated with various cellular activities aaa_5 COG1401 Cluster_332101 V1275560 RRMJ J Hemolysin A COG1189 Cluster_832584 V1275562 S Inherit from NOG: Phosphate-Selective Porin O and P 0XQB1 Cluster_405486 V1275563 S iron-regulated protein a 11RU6 Cluster_291354 V1275565 HYDC map00190,map00680,map00910,map01100 C -hydrogenase COG4624 Cluster_341070 V1275568 LSPA map03060 U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) 11G1Y Cluster_291355 V1275569 S NA 0YH2T Cluster_291356 V1275570 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG1754 Cluster_449136 V1275571 FABG map00061,map00780,map01040,map01100 S reductase 0XNW1 Cluster_728420 V1275572 I Diacylglycerol kinase COG1597 Cluster_507455 V1275573 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_567134 V1275574 J endoribonuclease L-psp COG0251 Cluster_467344 V1275575 CINA H competence damage-inducible protein COG1546 Cluster_731690 V1275577 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_573452 V1275578 S 5'-phosphate oxidase COG3576 Cluster_589510 V1275580 S NA 17D58@proNOG Cluster_292699 V1275581 CYDC map02010 V ABC transporter, ATP-binding protein COG1132 Cluster_567135 V1275582 V Mate efflux family protein COG0534 Cluster_596378 V1275583 TRXB map00240,map00450 O thioredoxin reductase COG0492 Cluster_748314 V1275585 YYZM S protein, conserved in bacteria COG4481 Cluster_711831 V1275586 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_360501 V1275587 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_478081 V1275596 C Hydrogenase large subunit domain protein COG4624 Cluster_292700 V1275597 S NA 12D73 Cluster_378925 V1275601 ABIGI S Abortive infection protein AbiGI 11WH3 Cluster_344193 V1275603 E amidohydrolase COG1473 Cluster_310781 V1275604 LYSC map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Aspartokinase COG0527 Cluster_552101 V1275607 S GtrA-like protein 11U0Q Cluster_755228 V1275608 TRPF map00400,map01100,map01110,map01230 E N-(5'-phosphoribosyl)anthranilate isomerase COG0135 Cluster_487435 V1275609 S Transcription termination antitermination factor NusG 0YUUM Cluster_294085 V1275613 ATP2C1 P p-type ATPase COG0474 Cluster_715191 V1275615 S Protein of unknown function (DUF3408) 11QAR Cluster_294086 V1275616 BTUS_1671 L Pfam:Phage_integr_N COG4974 Cluster_306610 V1275617 S Listeria-Bacteroides repeat domain (List_Bact_rpt) 0YG1D Cluster_711832 V1275618 SGCB map00052,map01100,map02060 G pts system COG3414 Cluster_705561 V1275619 PTS36C map00052,map01100,map02060 G PTS system, galactitol-specific IIc component COG3775 Cluster_534635 V1275620 S Domain of unknown function (DUF1858) 129SC Cluster_728421 V1275621 S NA 1242I Cluster_294087 V1275623 S NADP oxidoreductase coenzyme f420-dependent 0ZHKD Cluster_418029 V1275624 map00052,map01100,map02060 G PTS system, galactitol-specific IIc component COG3775 Cluster_423473 V1275625 M domain protein COG4932 Cluster_797249 V1275627 FUMC map00020,map00720,map01100,map01110,map01120,map05200,map05211 C fumarate hydratase class II COG0114 Cluster_403665 V1275628 S phosphoserine phosphatase 0Y1NG Cluster_294088 V1275629 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_766486 V1275634 M CHAP domain COG0741 Cluster_549210 V1275635 SCLAV_2282 M Peptidoglycan binding domain protein COG3409 Cluster_641246 V1275636 S Bacterial protein of unknown function (DUF898) 11UV5 Cluster_324597 V1275640 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_457005 V1275642 L Resolvase COG1961 Cluster_705562 V1275643 map02010 V ABC transporter transmembrane region COG1132 Cluster_312309 V1275644 MNME S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 Cluster_389505 V1275646 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_296842 V1275647 MUTL map03430 L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) COG0323 Cluster_751757 V1275649 YTEJ S rdd domain containing protein COG1714 Cluster_296843 V1275653 ERIC P Chloride channel COG0038 Cluster_407147 V1275654 RDGB map00230,map00240,map01100 F Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) COG0127 Cluster_344194 V1275655 S Beta-lactamase domain protein COG0491 Cluster_744966 V1275656 S HutD COG3758 Cluster_355469 V1275658 SRTB M (sortase) family COG3764 Cluster_296844 V1275659 PPAC map00190 C Manganese-dependent inorganic pyrophosphatase COG1227 Cluster_349005 V1275660 VIRB11 map03070,map05120 N, U Pfam:GSPII_E COG0630 Cluster_378926 V1275661 CYSB K Transcriptional regulator 16Q77@proNOG Cluster_543246 V1275662 ATPC map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG0355 Cluster_313803 V1275663 E amidohydrolase COG1473 Cluster_382419 V1275665 GUFA P Mediates zinc uptake. May also transport other divalent cations (By similarity) COG0428 Cluster_699418 V1275667 HEMD map00860,map01100,map01110 H uroporphyrinogeN-iii synthase 0XVP9 Cluster_305234 V1275672 K, T Peptidase m56 COG4219 Cluster_370405 V1275673 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_549211 V1275674 K DNA-binding helix-turn-helix protein 11XIQ Cluster_618222 V1275675 S Toxin-antitoxin system, toxin component 0XRRU Cluster_463171 V1275676 T Histidine kinase COG0642 Cluster_781399 V1275677 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_554989 V1275678 MCE map00280,map00620,map00630,map00640,map00720,map01100,map01120,map04011 I methylmalonyl-coA epimerase COG0346 Cluster_583029 V1275679 PTPB T Protein tyrosine phosphatase COG0394 Cluster_298235 V1275680 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_674551 V1275681 RPLX map03010 J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) COG0198 Cluster_576661 V1275682 RPLN map03010 J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) COG0093 Cluster_296845 V1275683 GSHA map00480,map01100 H glutamate--cysteine ligase COG3572 Cluster_621868 V1275684 map00051,map00520,map01100,map02060 G PTS system, sorbose subfamily, IIB component COG3444 Cluster_518020 V1275685 map00051,map00520,map01100,map02060 G PTS System COG3715 Cluster_766487 V1275689 PPIC O peptidylprolyl cis-trans isomerase COG0760 Cluster_410766 V1275691 map02020 T response regulator COG2197 Cluster_341071 V1275695 YLMH J s4 domain protein COG2302 Cluster_299499 V1275696 MURE map00300,map00550 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_683550 V1275697 DNAJ O DnaJ domain protein COG0484 Cluster_299500 V1275698 M Cell wall anchor domain protein 129AF Cluster_382420 V1275699 RFAF map00540,map01100 M heptosyltransferase ii COG0859 Cluster_859899 V1275700 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_309349 V1275702 S (LipO)protein 0XSV5 Cluster_504885 V1275703 METY map00270,map00450,map00920,map01100,map01110,map01230 E Cys/Met metabolism PLP-dependent enzyme COG2873 Cluster_449137 V1275706 V MatE COG0534 Cluster_299502 V1275708 METE map00270,map00450,map01100,map01110,map01230 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) COG0620 Cluster_683551 V1275709 YERC S protein, YerC YecD COG4496 Cluster_330552 V1275710 PFLA O Pyruvate formate-lyase COG1180 Cluster_649226 V1275713 PURM map00230,map01100,map01110 F phosphoribosylaminoimidazole synthetase COG0150 Cluster_387780 V1275714 S Membrane COG3949 Cluster_313804 V1275717 B, K radical SAM domain protein COG1243 Cluster_307926 V1275719 SRTC M (sortase) family COG3764 Cluster_728422 V1275720 K Transcriptional regulator COG1396 Cluster_482817 V1275721 S NA 0Z20Q Cluster_738272 V1275722 ASNA map00250,map00460,map00910,map01100,map01110,map01230 E asparagine synthetase A COG2502 Cluster_299503 V1275723 DCM map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_300900 V1275724 S conserved domain protein 0YAQR Cluster_300901 V1275725 PURF map00230,map00250,map01100,map01110 F glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_473713 V1275726 L site-specific recombinase, phage integrase family 0YBE3 Cluster_721752 V1275727 L site-specific recombinase, phage integrase family 0ZJK4 Cluster_592909 V1275728 WAAG map00540,map01100 M Glycosyl transferase (Group 1 16R0I@proNOG Cluster_531843 V1275729 RFAQ map00540,map01100 M glycosyl transferase, family 9 COG0859 Cluster_329143 V1275730 YIHW K Transcriptional regulator COG1349 Cluster_607097 V1275731 map00340,map01100,map01110,map01230 E histidinol phosphate phosphatase, hisj family COG1387 Cluster_543247 V1275732 S Abi-like protein 11VSQ Cluster_300902 V1275735 S copper amine 100EZ Cluster_758725 V1275738 FEOC K May function as a transcriptional regulator that controls feoABC expression (By similarity) 17IRP@proNOG Cluster_349006 V1275740 DNAJ3 O DnaJ domain protein COG2214 Cluster_391227 V1275747 PGSA map00564,map01100 I cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase COG0558 Cluster_302275 V1275748 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_614471 V1275751 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_515350 V1275752 PURN map00230,map00670,map01100,map01110 F phosphoribosylglycinamide formyltransferase COG0299 Cluster_592910 V1275753 PTS36A map00052,map01100,map02060 G PTS System COG1762 Cluster_683552 V1275754 SGCB map00052,map01100,map02060 G pts system COG3414 Cluster_329144 V1275755 M Bacteriophage peptidoglycan hydrolase COG0791 Cluster_567136 V1275756 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_645129 V1275757 S NA 125EB Cluster_718448 V1275758 RPST map03010 J Binds directly to 16S ribosomal RNA (By similarity) COG0268 Cluster_461058 V1275759 RPLJ map03010 J ribosomal protein l10 COG0244 Cluster_884433 V1275760 RPLL map03010 J Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) COG0222 Cluster_715192 V1275761 G aldose 1-epimerase COG2017 Cluster_567137 V1275762 LCD map00270,map00450,map00920,map01100,map01110,map01230 E Aminotransferase class I and II COG1168 Cluster_407148 V1275764 ATPA map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) COG1155 Cluster_494758 V1275767 BL03502 O phage portal protein HK97 family COG4695 Cluster_515351 V1275769 S NA 0Y02D Cluster_494759 V1275770 S Exporters of the RND superfamily COG1033 Cluster_789491 V1275771 S X-X-X-Leu-X-X-Gly heptad repeats COG1511 Cluster_302276 V1275772 RRGB M Lpxtg-motif cell wall anchor domain protein 0XSEP Cluster_363645 V1275773 S NA 0ZWX5 Cluster_443076 V1275774 S Pfam:DUF1393 1014A Cluster_702455 V1275776 MALQ map00500,map01100 G 4-alpha-glucanotransferase (EC 2.4.1.25) COG1640 Cluster_469463 V1275777 RBSR K Transcriptional regulator COG1609 Cluster_303721 V1275779 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_319976 V1275782 ADH map00051,map00363,map00591,map00625,map00650,map01100,map01120 C iron-containing alcohol dehydrogenase COG1454 Cluster_302277 V1275783 S NA 0YH2T Cluster_303722 V1275784 NUOD map00190,map00910,map01100 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) COG0852 Cluster_832586 V1275785 POTD map02010 E ABC transporter COG0687 Cluster_497268 V1275786 POTC map02010 P putrescine abc transporter COG1177 Cluster_661636 V1275787 S NA 11SH1 Cluster_618225 V1275789 SCE2282 L IS66 Orf2 family protein COG3436 Cluster_687987 V1275790 OCAR_5486 H Molybdopterin binding domain protein COG0303 Cluster_579787 V1275791 HIPO map00360 E amidohydrolase COG1473 Cluster_699419 V1275792 YHCG S Conserved Protein COG4804 Cluster_520593 V1275793 YHCH G Conserved Protein COG2731 Cluster_403666 V1275795 CSM6 S CRISPR-associated protein, Csm6 11FCG Cluster_762539 V1275796 FEOB P Ferrous iron transport protein b COG0370 Cluster_770195 V1275797 FEOA P Ferrous iron transport protein A COG1918 Cluster_755229 V1275798 P FeoA domain 0ZYS0 Cluster_457006 V1275799 RLUD J pseudouridine synthase COG0564 Cluster_576662 V1275800 S atp synthase 0ZZJH Cluster_737227 V1027402 BETP P Transporter COG1292 Cluster_819749 V1027403 S NA 186QP@proNOG Cluster_514554 V1027404 ACEE map00010,map00020,map00620,map00650,map01100,map01110,map01120 C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) COG2609 Cluster_517263 V1027405 S NA 0YQ2C Cluster_514555 V1027408 S NA 18AYC@proNOG Cluster_517264 V1027409 COMB S pilus assembly protein PilW 17M9P@proNOG Cluster_707793 V1027413 S sigma-70, region 4 11JJM Cluster_714273 V1027414 S phage-like element pbsx protein XkdM 124NI Cluster_695172 V1027418 map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_517265 V1027419 REGS map02020 T Histidine kinase 16TGJ@proNOG Cluster_581994 V1027422 S NA 0YR6I Cluster_695173 V1027423 YPEA map00350,map00362,map00627,map00642,map00903,map01120 S acetyltransferase COG0456 Cluster_517267 V1027426 FAS map00061,map01100 I fatty acid synthase COG4982 Cluster_517268 V1027427 LPQC Q polyhydroxybutyrate depolymerase COG3509 Cluster_551275 V1027428 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_519841 V1027429 PTSI map00051,map01100,map02060 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) COG1080 Cluster_562989 V1027431 HUTH map00340,map01100 E Histidine ammonia-lyase COG2986 Cluster_517269 V1027432 YDJI G virion core protein (Lumpy skin disease COG4260 Cluster_660341 V1027433 PGN_0945 K Transcriptional regulator, TetR family 11T38 Cluster_517270 V1027434 S NA 0ZTYV Cluster_514557 V1027435 MNTB map02010 P (ABC) transporter COG1121 Cluster_812267 V1027437 PBRT P iron permease COG0672 Cluster_769196 V1027438 BMUL_5712 map00330,map01100,map01110,map01210,map01230 E Gcn5-related n-acetyltransferase 17MIX@proNOG Cluster_517271 V1027439 P tonB-dependent Receptor COG4206 Cluster_677661 V1027441 PATATIN S K07001 NTE family protein COG1752 Cluster_517272 V1027445 PYC map00020,map00620,map00720,map01100,map01120,map01230 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) COG1038 Cluster_517273 V1027446 map02010 P ABC transporter COG1840 Cluster_517274 V1027450 YBBP Q ABC transporter, permease COG3127 Cluster_517275 V1027451 G extracellular solute-binding protein family 1 COG1653 Cluster_557031 V1027454 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_517276 V1027455 E extracellular ligand-binding receptor COG0683 Cluster_517277 V1027457 S Ankyrin repeat protein COG0666 Cluster_620767 V1027458 LEMA S LemA family COG1704 Cluster_560085 V1027459 RPLM map03010 J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) COG0102 Cluster_862998 V1027460 HUTU map00340,map01100 E Urocanate hydratase COG2987 Cluster_701638 V1027462 PNTAB map00760,map01100 C transhydrogenase (subunit alpha COG3288 Cluster_519842 V1027464 TNP7109-31 L Transposase COG3328 Cluster_517279 V1027465 CZCA P AcrB/AcrD/AcrF family COG3696 Cluster_643921 V1027466 S Nucleotidyl transferase of unknown function (DUF1814) 11TSU Cluster_792199 V1027468 YEAO S MarR family Transcriptional regulator COG3189 Cluster_776568 V1027469 map00910 S 2-nitropropane dioxygenase COG2070 Cluster_519843 V1027472 LGAS_0606 S Phage Portal Protein 0XP33 Cluster_733959 V1027476 URTE2 map02010 E abc transporter, ATP-binding protein COG0410 Cluster_875082 V1027477 AMIE map00330,map00360,map00380,map00627,map00643,map01120 S Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) COG0388 Cluster_640004 V1027479 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_517280 V1027480 M NA 0ZYVM Cluster_517281 V1027481 YAPE M, U Outer membrane autotransporter COG3468 Cluster_808257 V1027486 RSFS S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) COG0799 Cluster_668888 V1027487 L NA 0YKV1 Cluster_682200 V1027488 S NA 0ZHU9 Cluster_519846 V1027490 L resolvase COG1961 Cluster_788420 V1027492 K SpoVT_AbrB 16ZST@proNOG Cluster_628211 V1027493 UUP S ABC transporter COG0488 Cluster_710852 V1027495 S K07001 NTE family protein COG1752 Cluster_780145 V1027499 S Protein of unknown function (DUF2970) 17Q6M@proNOG Cluster_916722 V1027500 CTAG map00190,map01100 O Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity) COG3175 Cluster_519847 V1027501 GLCB map00620,map00630,map01100,map01120 C Malate synthase COG2225 Cluster_519848 V1027503 Y2188 S Host specificity protein COG4733 Cluster_643922 V1027507 KT71_01965 L Transposase COG3436 Cluster_519850 V1027509 DCTA map02020 C Sodium:dicarboxylate symporter family COG1301 Cluster_519851 V1027511 YJGN S Membrane COG4269 Cluster_673162 V1027513 V Type I site-specific deoxyribonuclease COG0610 Cluster_519853 V1027514 S abc transporter atp-binding protein 11J2E Cluster_519854 V1027515 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin 0XQTW Cluster_519855 V1027516 J Anticodon-binding domain of tRNA COG0060 Cluster_673163 V1027517 RPLX map03010 J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) COG0198 Cluster_519856 V1027518 ALCA map00310,map01120 Q L-lysine 6-monooxygenase (NADPH) COG3486 Cluster_522537 V1027519 NADE map00760,map01100 H nh(3)-dependent nad( ) synthetase COG0171 Cluster_519857 V1027520 G Major Facilitator superfamily 11Q79 Cluster_737229 V1027522 S NA 0ZHU9 Cluster_551276 V1027524 BMUL_4425 map02010 P Binding-protein-dependent transport systems inner membrane component COG0601 Cluster_519858 V1027526 S Rib/alpha-like repeat 10008 Cluster_522539 V1027527 XYLB map00040,map01100 G xylulokinase COG1070 Cluster_883264 V1027528 map00071,map00380,map00627,map01120 C Cytochrome p-450 COG0369 Cluster_522540 V1027532 FABZ map00061,map00780,map01100 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) COG0764 Cluster_519859 V1027534 P monooxygenase COG2072 Cluster_519860 V1027540 ASDA map00250,map00270,map00300,map01100,map01110,map01230 E Aspartate aminotransferase COG0436 Cluster_847194 V1027544 COMGC map02020,map03070 U Competence protein 0XUCS Cluster_522541 V1027548 HYI map00630,map01100 G Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) COG3622 Cluster_686581 V1027549 I Acyl-transferase COG1835 Cluster_569274 V1027552 PHAC map00190,map00910,map01100 P Monovalent cation H antiporter subunit C COG1006 Cluster_695174 V1027556 S Inherit from COG: PAAR repeat-containing protein COG5444 Cluster_664556 V1027559 HEMA map00860,map01100,map01110 H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) COG0373 Cluster_522544 V1027560 ISPB map00900,map01100,map01110 H synthase COG0142 Cluster_522545 V1027564 S NA 0YH2T Cluster_854718 V1027566 L reverse transcriptase COG3344 Cluster_707794 V1027568 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_522547 V1027569 IMPF S type VI secretion system, lysozyme-related protein COG3518 Cluster_522549 V1027571 M domain protein COG4932 Cluster_843203 V1027573 YPDA map00240,map00450 O pyridine nucleotide-disulfide oxidoreductase COG0492 Cluster_863001 V1027578 COMF S Competence protein COG1040 Cluster_522552 V1027580 AMSB M Glycosyl transferase, family 2 COG0463 Cluster_525431 V1027581 COPS map02020 T heavy metal sensor signal transduction histidine kinase COG0642 Cluster_750754 V1027585 OCAR_5506 O 20S proteasome, A and B subunits COG3484 Cluster_819751 V1027586 RPSA map00900,map01100,map01110,map03010 J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) COG0539 Cluster_522553 V1027587 ACD map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I acyl-CoA dehydrogenase COG1960 Cluster_522554 V1027588 map00071,map01100,map03320,map04146,map04920 I amp-dependent synthetase and ligase COG0318 Cluster_525433 V1027590 SMOC K Transcriptional regulator COG2390 Cluster_522556 V1027592 NAGZ map00460,map00500,map00520,map00940,map01100,map01110 G Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) COG1472 Cluster_525434 V1027593 BMUL_1008 S metallophosphoesterase COG2908 Cluster_525435 V1027594 FECS map02010 P Iron ABC superfamily ATP binding cassette transporter, solute-binding protein COG0614 Cluster_522557 V1027595 V type i restriction COG0732 Cluster_522558 V1027596 PHOA map00627,map00790,map01100,map01120,map02020 P alkaline phosphatase COG1785 Cluster_525436 V1027597 S NA 0XTEF Cluster_525437 V1027600 map00330,map00360,map00380,map00627,map00643,map01120 Q amidase (EC 3.5.1.4 COG0154 Cluster_412587 V1275802 TEX K domain protein COG2183 Cluster_618226 V1275803 S NA 0YVSG Cluster_502472 V1275804 S NA 0ZHU9 Cluster_653308 V1275805 YJGF J endoribonuclease L-psp COG0251 Cluster_385977 V1275806 TELA P Resistance protein COG3853 Cluster_303723 V1275807 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_318494 V1275808 S ABC transporter solute-binding protein COG4134 Cluster_387781 V1275809 C radical SAM domain protein COG1032 Cluster_384197 V1275810 RPE map00030,map00040,map00710,map01100,map01110,map01120,map01230 G ribulose-phosphate 3-epimerase COG0036 Cluster_762540 V1275812 P Protein of unknown function DUF47 COG1392 Cluster_917864 V1275813 RPSD map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) COG0522 Cluster_504886 V1275815 LYTS map02020 T Histidine kinase COG3275 Cluster_576663 V1275816 K TRANSCRIPTIONAl REGULATOR GntR family COG1725 Cluster_540318 V1275818 YPSC L Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) COG0116 Cluster_573453 V1275819 LDTA S ErfK YbiS YcfS YnhG COG1376 Cluster_305235 V1275820 L helicase COG4646 Cluster_419821 V1275821 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG0582 Cluster_876257 V1275822 RNY S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 Cluster_306612 V1275824 HEMN map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_451118 V1275825 V Type I restriction enzyme R protein N terminus (HSDR_N) COG0610 Cluster_305236 V1275827 ICD map00020,map00290,map00480,map00720,map01100,map01110,map01120,map01210,map01230,map04146 C Isocitrate dehydrogenase, NAD-dependent COG0473 Cluster_482818 V1275828 GLNP E Abc transporter COG0765 Cluster_307927 V1275830 FUCI map00051 G Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) COG2407 Cluster_375369 V1275831 M Cell wall anchor domain protein 129AF Cluster_307928 V1275832 YXCA I coA-substrate-specific enzyme activase COG3581 Cluster_789492 V1275836 M Inherit from NOG: glycosyl transferase 11WNF Cluster_306613 V1275837 L helicase COG4646 Cluster_307929 V1275838 S na solute symporter 1C83J@synNOG Cluster_434994 V1275840 POLA_2 L DNA polymerase 0XRUF Cluster_657437 V1275841 ASP S Alkaline-shock protein COG1302 Cluster_335118 V1275845 L Site-specific recombinase COG1961 Cluster_427212 V1275847 PHNE map02010 P phosphonate abc transporter COG3639 Cluster_396635 V1275848 LEXA K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) COG1974 Cluster_307930 V1275849 DCTP C symporter COG1301 Cluster_499937 V1275850 S F420-0:Gamma-glutamyl ligase 0Y085 Cluster_310782 V1275851 S osta family 0XUST Cluster_338197 V1275852 T Histidine kinase COG0642 Cluster_389506 V1275854 S Inherit from COG: LOR SDH bifunctional protein conserved domain protein COG1915 Cluster_824995 V1275855 map02020 T ATPase histidine kinase DNA gyrase B HSP90 domain protein 0XNMH Cluster_307932 V1275856 ABGB E aminobenzoyl-glutamate utilization protein B COG1473 Cluster_382421 V1275858 M hydrolase, family 25 COG3757 Cluster_645130 V1275861 YJFO S biofilm stress and motility protein A 17KU3@proNOG Cluster_309350 V1275862 ZNUC map02010 P ABC-type Mn Zn transport system, ATPase component COG1121 Cluster_702457 V1275863 YHGE S domain protein COG1511 Cluster_678982 V1275864 ADH map00010,map00051,map00071,map00350,map00362,map00363,map00591,map00620,map00621,map00622,map00625,map00626,map00630,map00650,map01100,map01110,map01120 C alcohol dehydrogenase COG1454 Cluster_596380 V1275865 S NA 0XT4D Cluster_526244 V1275866 THYX map00240,map00340,map00350,map00624,map00670,map01120 F Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) COG1351 Cluster_497269 V1275867 M Sulfatase COG1368 Cluster_607098 V1275868 map02010 E, P ABC transporter COG4608 Cluster_621869 V1275869 OPPF map02010 E (ABC) transporter COG4608 Cluster_467345 V1275871 S Membrane Spanning Protein COG4720 Cluster_457007 V1275872 DEOC map00030 F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) COG0274 Cluster_840342 V1275873 S NA 0XWKC Cluster_372037 V1275875 ISPA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_913535 V1275876 RRMJ J Hemolysin A COG1189 Cluster_370406 V1275878 map00520 E, M N-acetylneuraminate lyase COG0329 Cluster_309351 V1275879 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_607099 V1275880 UNG map03410,map05340 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 Cluster_310783 V1275881 APEA map00480,map01100 E M18 family aminopeptidase COG1362 Cluster_373662 V1275882 POTB map02010 P ABC transporter, permease COG1176 Cluster_358823 V1275883 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_310784 V1275886 CAFA map03018 J ribonuclease COG1530 Cluster_583030 V1275888 ARGS map00970 J arginyL-tRNA synthetase COG0018 Cluster_645131 V1275890 CAFA map03018 J ribonuclease COG1530 Cluster_387782 V1275892 ERIC P Chloride channel COG0038 Cluster_341072 V1275893 M (sortase) family COG3764 Cluster_653309 V1275895 map00240,map00250,map01100 F Aspartate carbamoyltransferase COG0540 Cluster_310786 V1275896 map00260,map01100 C pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_408923 V1275897 L helicase COG4646 Cluster_573455 V1275898 RPSI map03010 J 30S ribosomal protein S9 COG0103 Cluster_437062 V1275901 P Type I phosphodiesterase / nucleotide pyrophosphatase COG3119 Cluster_375370 V1275902 S NA 1224P Cluster_398377 V1275903 PLDB map00363,map00564,map00960,map01120 I alpha beta COG2267 Cluster_312310 V1275908 YTFP S hi0933 family COG2081 Cluster_401871 V1275909 PBUG S Xanthine uracil vitamin C permease COG2252 Cluster_382422 V1275912 ZNUA map02010 P transporter substrate-binding protein COG0803 Cluster_341073 V1275913 NHAC map00680 C Na H antiporter COG1757 Cluster_471621 V1275914 FEPC map02010 P ABC, transporter COG1120 Cluster_410767 V1275917 S host cell surface-exposed lipoprotein 11S42 Cluster_363646 V1275918 TRKH P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) COG0168 Cluster_312311 V1275919 BH0416 L Transposase COG3464 Cluster_358824 V1275920 E ABC, transporter COG0765 Cluster_439079 V1275921 S Protein of unknown function (DUF541) 0YM36 Cluster_872153 V1275922 S Thioesterase COG0824 Cluster_401872 V1275923 S Phage virion morphogenesis family 0Y00D Cluster_579788 V1275924 RSMC J methyltransferase COG2813 Cluster_427213 V1275925 NRFA map00910,map01120,map05132 P Plays a role in nitrite reduction (By similarity) COG3303 Cluster_313805 V1275926 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_492273 V1275927 TKTA map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_394857 V1275928 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_557909 V1275929 RPLC map03010 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 Cluster_445066 V1275930 S Metal Dependent Phosphohydrolase COG2316 Cluster_821026 V1275932 YHBY J Rna-binding protein COG1534 Cluster_543248 V1275933 NHAA map00680 P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) COG3004 Cluster_702458 V1275934 RPLE map03010 J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COG0094 Cluster_696143 V1275935 K Transcriptional regulator COG3604 Cluster_705563 V1275936 YTQB map00340,map00350,map00624,map01120 Q rRNA Methylase COG0500 Cluster_480480 V1275937 RLUB J Pseudouridine synthase COG1187 Cluster_313806 V1275938 S NA 0Y12S Cluster_313807 V1275939 OPPF map02010 E, P ABC transporter, ATP-binding protein COG4608 Cluster_465255 V1275940 SRTC M (sortase) family COG3764 Cluster_313808 V1275941 SAGG map02010 V ABC transporter, ATP-binding protein COG1131 Cluster_370407 V1275943 GLNQ E (ABC) transporter COG1126 Cluster_315378 V1275944 S NA COG4926 Cluster_773897 V1275945 C Fe-S cluster domain protein COG2878 Cluster_531845 V1275949 FPRA C domain protein COG0426 Cluster_734941 V1275950 XTH map03410 L Exodeoxyribonuclease III COG0708 Cluster_408924 V1275951 BL01877 K Transcriptional regulator COG1309 Cluster_683553 V1275953 map02010 P Cobalt transport protein COG0619 Cluster_583031 V1275956 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_526245 V1275957 RUVA map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) COG0632 Cluster_649227 V1275958 RUVB map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 Cluster_599879 V1275963 S copper amine 121X1 Cluster_329145 V1275964 GTFA map00500 G Sucrose phosphorylase COG0366 Cluster_316904 V1275966 M Inherit from COG: filamentous hemagglutinin family outer membrane protein COG3209 Cluster_692413 V1275968 S transposase 11RMG Cluster_921771 V1275974 YIHP G transporter COG2211 Cluster_437063 V1275975 YIHQ map00052,map00500,map01100 G Alpha-glucosidase COG1501 Cluster_315379 V1275976 D ftsk SpoIIIE family protein COG1674 Cluster_355470 V1275977 S Inherit from COG: ATPase (AAA COG1373 Cluster_507456 V1275978 OPPF map02010 E (ABC) transporter COG4608 Cluster_678984 V1275979 APPD map02010 E, P ABC transporter COG0444 Cluster_316905 V1275981 SUN_0728 L transposase (IS4 family) protein 12CNV Cluster_316906 V1275982 SCRA map00500,map02060 G phosphotransferase system, EIIB COG1264 Cluster_316907 V1275983 AROF map00400,map01100,map01110,map01230 E phospho-2-dehydro-3-deoxyheptonate aldolase COG2876 Cluster_423474 V1275984 ARSM map00130,map00340,map00350,map00624,map01100,map01110,map01120 S methyltransferase, type 11 0XSKB Cluster_471622 V1275985 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_731692 V1275986 V type I restriction modification DNA specificity domain COG0732 Cluster_316908 V1275987 BMUL_5605 S VWA-like domain (DUF2201) 0XSQB Cluster_793283 V1275988 S NA 17Y8U@proNOG Cluster_554991 V1275989 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_405487 V1275990 V Inherit from COG: Type I site-specific deoxyribonuclease COG0610 Cluster_316909 V1275991 T Histidine kinase COG0642 Cluster_349007 V1275992 CYDC map02010 V Abc transporter COG1132 Cluster_316910 V1275993 FEOB P Ferrous iron transport protein b COG0370 Cluster_316911 V1275994 DAPE map00300,map00330,map01100,map01110,map01120,map01210,map01230 E Acetylornithine deacetylase COG0624 Cluster_625663 V1275996 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_586216 V1275997 PRSA O Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) COG0760 Cluster_447126 V1275999 RNFG C Electron transport complex, RnfABCDGE type, G subunit COG4659 Cluster_380646 V1276001 map02010 P binding-protein-dependent transport systems inner membrane Component COG1175 Cluster_318495 V1276002 M domain protein COG4932 Cluster_414451 V1276003 YGEY map00330,map01100,map01110,map01210,map01230 E M20 DapE family protein YgeY COG0624 Cluster_318496 V1276005 DNAG map03030 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 Cluster_560962 V1276006 SORC K regulatoR COG2390 Cluster_367074 V1276007 L Primosomal protein, DnaI COG1484 Cluster_696144 V1276008 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_367075 V1276009 GATA map00970,map01100 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) COG0154 Cluster_457008 V1276012 P Chromate COG2059 Cluster_510049 V1276014 S Tail tape measure protein, TP901 family COG5280 Cluster_319977 V1276015 S NA 0XQ5E Cluster_603478 V1276018 MGTA map00190 P Atpase, p-type (Transporting), had superfamily, subfamily ic COG0474 Cluster_347409 V1276019 YADC U fimbrial-like protein YadC 17HHX@proNOG Cluster_380647 V1276021 UMUC L ImpB MucB SamB family protein COG0389 Cluster_318497 V1276022 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_327659 V1276023 map02010 V ABC transporter COG1136 Cluster_319979 V1276025 PULA G Glycogen debranching enzyme COG1523 Cluster_344195 V1276026 HTPX map00900 O Protease HtpX homolog COG0501 Cluster_554992 V1276028 FIC D cell filamentation protein COG2184 Cluster_449138 V1276029 FRLD G sugar kinase COG0524 Cluster_478082 V1276030 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_319980 V1276031 CSPA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_410768 V1276032 HCP C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) COG1151 Cluster_360502 V1276033 L site-specific recombinase, phage integrase family 10A1H Cluster_355471 V1276034 F Inherit from COG: deaminase COG0402 Cluster_649229 V1276035 DPPD map02010 E, P (ABC) transporter COG0444 Cluster_531846 V1276036 DPPC P ABC transporter permease protein COG1173 Cluster_596381 V1276037 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_603479 V1276039 S mobilization protein 11J0G Cluster_596382 V1276040 HLY map00270,map00450,map00920,map01100,map01110,map01230 E Aminotransferase class I and II COG1168 Cluster_570225 V1276041 map00280,map00290,map00310,map00330,map00360,map00472,map00473,map00770,map01100,map01110,map01210,map01230 E Aminotransferase COG0115 Cluster_333607 V1276043 S ATPase (AAA COG1373 Cluster_339619 V1276044 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_449139 V1276045 YBBC V conserved protein UCP016719 COG3876 Cluster_321453 V1276046 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_494761 V1276048 G PTS system, sorbose subfamily, IIB component COG3444 Cluster_321454 V1276049 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_586217 V1276052 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_708637 V1276054 GROS O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) COG0234 Cluster_321455 V1276055 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_401873 V1276056 GLNN map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG3968 Cluster_888332 V1276057 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_836413 V1276059 K Transcriptional regulator, TetR family 0YTCU Cluster_687989 V1276061 S Cupin domain 0ZNGI Cluster_391228 V1276064 K Transcriptional regulator, TetR family 0YTCU Cluster_323013 V1276065 S Membrane 0XPM4 Cluster_447127 V1276066 VANZ V VanZ-like protein COG4767 Cluster_478083 V1276068 TILS D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) COG0037 Cluster_603480 V1276072 SCLAV_2642 S Lipase esterase 11GU9 Cluster_380648 V1276074 S peptidase, S41 11U77 Cluster_329146 V1276076 V ABC transporter COG1132 Cluster_770196 V1276077 YBIT S ABC transporter, ATP-binding protein COG0488 Cluster_492274 V1276078 GPPA map00230 F, P ppx gppa phosphatase COG0248 Cluster_330553 V1276079 E Family 5 COG0747 Cluster_323015 V1276080 S NA 11NI8 Cluster_323016 V1276081 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit alpha COG0587 Cluster_573457 V1276082 L Integrase COG0582 Cluster_324598 V1276085 EXPZ S Abc transporter COG0488 Cluster_324599 V1276087 S NA 0YZ82 Cluster_323017 V1276088 S NA 11NI8 Cluster_323018 V1276089 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_394859 V1276090 S NA 11IN7 Cluster_324600 V1276092 NTPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_377145 V1276093 F HDc COG0232 Cluster_324602 V1276095 SELA map00450,map00970 E Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity) COG1921 Cluster_324603 V1276097 DAPE1 map00300,map00310,map00330,map00780,map01100,map01110,map01120,map01210,map01230 E peptidase COG0624 Cluster_324604 V1276098 S Abi-like protein 11VSQ Cluster_324605 V1276099 S Domain-Containing protein 122NA Cluster_489774 V1276101 COAD map00770,map01100 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) COG0669 Cluster_324606 V1276102 SASC S surface protein 11FPX Cluster_378927 V1276103 S Relaxase Mobilization nuclease domain protein 0XRAY Cluster_401874 V1276104 map03420,map03430 L helicase COG0210 Cluster_324607 V1276105 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_412588 V1276108 FBPA K Fibronectin-binding protein COG1293 Cluster_429111 V1276109 BIOY map02010 S bioY protein COG1268 Cluster_434995 V1276111 SCPA S Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) COG1354 Cluster_385978 V1276112 S NA 0Y1WP Cluster_326091 V1276113 S NA 11QEZ Cluster_431070 V1276114 FUCP G glucose galactose transporter COG0738 Cluster_824996 V1276115 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_326092 V1276117 M protein (LPxTG motif) COG4932 Cluster_365384 V1276118 FABD map00061,map01100 I Malonyl CoA-acyl carrier protein transacylase COG0331 Cluster_557910 V1276119 RBSA map02010 P ATP-binding protein COG1129 Cluster_625664 V1276120 map02010 G ABC, transporter COG1172 Cluster_350635 V1276121 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_453047 V1276122 SP_0239 S UPF0210 protein COG2848 Cluster_362077 V1276123 BDHA map00051,map00363,map00591,map00625,map00650,map01100,map01120 C alcohol dehydrogenase COG1979 Cluster_339620 V1276124 map00130,map00770,map01100,map01110 S Methyltransferase 0ZVQZ Cluster_327660 V1276127 S Uncharacterized conserved protein (DUF2075) 0XPB6 Cluster_327661 V1276129 AMRA M polysaccharide biosynthesis protein COG2244 Cluster_586218 V1276130 FDHB map00630,map00680,map01100,map01120 C Iron-sulfur COG0437 Cluster_607100 V1276131 NARB map00630,map00680,map00910,map01100,map01120 C Molydopterin dinucleotide binding domain COG0243 Cluster_423475 V1276133 S NA 109CF Cluster_433088 V1276135 S NA 0Y46D Cluster_445067 V1276136 GPMB map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_773898 V1276138 FOLA map00670,map00790,map01100 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) COG0262 Cluster_546179 V1276139 P Chromate transport protein COG2059 Cluster_439080 V1276140 P Citrate transporter COG1055 Cluster_329147 V1276141 BCELL_1025 L Integrase COG2801 Cluster_327662 V1276142 map00300,map01100,map01120,map01230 E Dipeptidase COG0624 Cluster_453048 V1276144 S NA 0XYT7 Cluster_431071 V1276145 E amino acid COG0531 Cluster_482819 V1276147 CAT V Chloramphenicol acetyltransferase COG4845 Cluster_401875 V1276148 YHCG S Conserved Protein COG4804 Cluster_327663 V1276149 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_362078 V1276150 TYPA T gtp-binding protein typa COG1217 Cluster_789494 V1276152 V type III restriction enzyme 0ZVQ5 Cluster_445068 V1276154 T response regulator COG0745 Cluster_817150 V1276155 YIIX S Repressor protein MetJ 174T2@proNOG Cluster_789495 V1276156 RPME map03010 J Binds the 23S rRNA (By similarity) COG0254 Cluster_731693 V1276157 LACC map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G tagatose-6-phosphate kinase COG1105 Cluster_489775 V1276158 LACD map00052,map01100 G Aldolase COG3684 Cluster_327664 V1276159 PFLD map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_329148 V1276160 HYMB map00190,map00910,map01100 C NADH dehydrogenase COG1894 Cluster_645132 V1276162 E Branched-chain amino acid transport 12CC7 Cluster_751760 V1276163 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_458988 V1276169 GLTS E Sodium Glutamate Symporter COG0786 Cluster_329149 V1276170 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_492275 V1276171 map00340,map00350,map00624,map01120 Q O-Methyltransferase COG3315 Cluster_455062 V1276172 map00260,map01100 C pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_801218 V1276173 C fad dependent oxidoreductase COG0579 Cluster_489776 V1276175 LTRA L reverse transcriptase COG3344 Cluster_583032 V1276176 K TRANSCRIPTIONAl REGULATOR GntR family COG1725 Cluster_678985 V1276177 V ABC transporter COG1131 Cluster_329150 V1276178 COBQ map00860,map01100,map02010 H catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) COG1492 Cluster_329151 V1276179 PEPTIDASE E prolyl oligopeptidase COG1505 Cluster_350636 V1276180 LON map04112 O ATP-dependent Lon protease COG4930 Cluster_355472 V1276184 S NA 0Z4SK Cluster_412589 V1276185 SPAK T Histidine kinase COG0642 Cluster_443077 V1276186 S NA 11X7Q Cluster_614474 V1276188 map02010 V Inherit from bactNOG: (ABC) transporter COG1132 Cluster_570226 V1276189 V ABC transporter transmembrane region COG1132 Cluster_453049 V1276190 LACB map00030,map00052,map00710,map01100,map01110,map01120,map01230 G galactose-6-phosphate isomerase subunit LacB COG0698 Cluster_478084 V1276192 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_377146 V1276196 S NA 1249W Cluster_365385 V1276197 MANY map00051,map00520,map01100,map02060 G PTS System COG3715 Cluster_576664 V1276198 S Bacterial mobilisation protein (MobC) 11K3U Cluster_425272 V1276199 ATPC map00190,map00680,map01100 C ATP synthase, subunit 0XPA7 Cluster_330554 V1276200 CAT map00281,map00620,map00626,map01110,map01120 C Transferase COG0427 Cluster_332102 V1276201 CNA M domain protein 0ZWTG Cluster_330555 V1276203 S YbbR-like protein COG4856 Cluster_711834 V1276205 AHCY map00270,map01100 H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) COG0499 Cluster_583033 V1276206 F Amidohydrolase family COG0402 Cluster_330557 V1276207 GLCD map00620,map00630,map01100,map01110,map01120 C FAD linked oxidase domain-containing protein COG0277 Cluster_625665 V1276208 map02010 G ABC transporter COG1653 Cluster_332103 V1276209 L CRISPR-associated protein, Csn1 family COG3513 Cluster_330558 V1276210 CYDD map02010 V ABC, transporter COG4988 Cluster_332104 V1276211 S NA 0ZTYV Cluster_332105 V1276212 SURB S G5 domain protein 0ZVV3 Cluster_537527 V1276214 S -acetyltransferase 11IA1 Cluster_332106 V1276215 LPXD map00540,map01100 M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) COG1044 Cluster_332107 V1276216 CITE map00020,map01110,map02020 C Citrate lyase subunit beta COG2301 Cluster_410769 V1276219 P The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) 0XNUJ Cluster_358825 V1276220 RBSB map02010,map02030 G Periplasmic binding protein LacI transcriptional regulator COG1879 Cluster_670158 V1276221 CUTA S divalent ion tolerance protein COG3323 Cluster_332108 V1276222 V ABC transporter, permease protein 0XP9H Cluster_332109 V1276223 BMUL_5034 S Aminoglycoside phosphotransferase 0ZRQS Cluster_332110 V1276224 RECG map03440 L ATP-dependent DNA helicase recg COG1200 Cluster_382423 V1276225 ENC_23920 S Phospholipid glycerol acyltransferase COG3176 Cluster_455063 V1276226 map02010 V abc transporter COG1132 Cluster_583034 V1276227 S membrAne 11GVZ Cluster_332111 V1276228 YPFJ S zinc metallopeptidase COG2321 Cluster_576665 V1276229 V ABC transporter COG1131 Cluster_610747 V1276230 GNTR K TRANSCRIPTIONAl REGULATOR GntR family COG1725 Cluster_332112 V1276231 METN map02010 P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COG1135 Cluster_332113 V1276232 YJHA S Endonuclease Exonuclease phosphatase 0XNVA Cluster_633197 V1276233 AGP map00010,map01120 S Phosphatase 0XRK8 Cluster_333608 V1276234 PEPP E peptidase, M24 COG0006 Cluster_380649 V1276235 S HTH_XRE 0ZZ7A Cluster_583035 V1276236 MSCL M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 Cluster_333609 V1276237 PHND map02010 P Phosphonate ABC transporter, periplasmic COG3221 Cluster_549212 V1276238 MODA map02010 P ABC transporter, periplasmic molybdate-binding protein COG0725 Cluster_657438 V1276239 MODB map02010 P molybdate abc transporter COG4149 Cluster_352140 V1276248 S Major capsid protein 10Y9G Cluster_773899 V1276250 S NA 101UU Cluster_625666 V1276251 S NA 101UU Cluster_335119 V1276252 HFLX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COG2262 Cluster_338198 V1276253 K LysR substrate binding domain 0ZWEJ Cluster_339621 V1276254 YCAM E amino acid COG0531 Cluster_781402 V1276255 YABO J s4 domain protein COG1188 Cluster_711835 V1276256 HUP L DNA-binding protein COG0776 Cluster_335120 V1276258 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_335122 V1276260 RECB map03440 L UvrD REP helicase COG1074 Cluster_335123 V1276261 S Membrane COG3949 Cluster_603481 V1276262 TCSS map02020 T Histidine kinase COG0642 Cluster_777588 V1276263 S NA 0Y5HQ Cluster_335124 V1276264 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_801219 V1276265 GLPC map00564 C glycerol-3-phosphate dehydrogenase, anaerobic, C subunit COG0247 Cluster_335125 V1276266 S NA 0YC46 Cluster_335126 V1276267 UDP map00240,map00983,map01100 F Uridine phosphorylase COG2820 Cluster_384198 V1276268 V type I restriction-modification system COG0286 Cluster_520595 V1276274 GND map00030,map00480,map01100,map01110,map01120 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) COG0362 Cluster_526246 V1276275 V (ABC) transporter 0XQRE Cluster_699421 V1276276 S NA 0ZEYT Cluster_336644 V1276279 M Inherit from NOG: domain protein 0XQTW Cluster_805387 V1276280 S X-X-X-Leu-X-X-Gly heptad repeats COG1511 Cluster_335127 V1276281 map00550 M Penicillin-binding Protein dimerisation domain COG0772 Cluster_526247 V1276282 HSDM-1 V Type I restriction-modification system, M subunit COG0286 Cluster_336645 V1276284 YCHF J gtp-binding protein COG0012 Cluster_586219 V1276285 PHEA map00400,map01100,map01110,map01230 E Prephenate dehydratase COG0077 Cluster_610748 V1276286 AROK map00400,map01100,map01110,map01230 E Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) COG0703 Cluster_342593 V1276287 PPAC map00190 C Manganese-dependent inorganic pyrophosphatase COG1227 Cluster_335128 V1276288 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_336646 V1276289 APRE O Peptidase S8 and S53 subtilisin kexin sedolisin COG4412 Cluster_336647 V1276290 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_412590 V1276291 RBR C Rubrerythrin COG1592 Cluster_813418 V1276292 FTSW map04112 D cell cycle protein, FtsW RodA SpoVE family COG0772 Cluster_336648 V1276293 UXUA map00040,map01100 G Catalyzes the dehydration of D-mannonate (By similarity) COG1312 Cluster_586220 V1276294 S NA 11U4D Cluster_708638 V1276295 map00300,map01100,map01110,map01120,map01230 S dihydrodipicolinate reductase COG3804 Cluster_603482 V1276296 YIDG S Inner membrane protein yidG 17CJX@proNOG Cluster_523334 V1276297 COBS map00860,map01100 H Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) COG0368 Cluster_412591 V1276301 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_552103 V1276302 APT map00230,map01100 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) COG0503 Cluster_396636 V1276303 GLXK map00260,map00561,map00630,map01100,map01110 G Glycerate kinase COG1929 Cluster_649230 V1276304 YERC S protein, YerC YecD COG4496 Cluster_589511 V1276305 F formate-tetrahydrofolate ligase COG2759 Cluster_412592 V1276307 FPRA C domain protein COG0426 Cluster_414452 V1276308 METG J emap domain COG0073 Cluster_773900 V1276311 RARD S rard protein COG2962 Cluster_510050 V1276312 S NA 11YG8 Cluster_437064 V1276314 M ErfK YbiS YcfS YnhG COG1376 Cluster_405488 V1276315 S s-layer domain-containing protein 11ZJU Cluster_721753 V1276316 RAIA J ribosomal subunit Interface protein COG1544 Cluster_336650 V1276318 L integrase family COG0582 Cluster_336651 V1276320 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_728425 V1276322 map02010 S YodA lipocalin-like domain 11KBP Cluster_489777 V1276323 ZNUA map02010 P transporter substrate-binding protein COG0803 Cluster_540320 V1276325 map05100 G s-layer domain protein 11IBF Cluster_748315 V1276326 YWDH map00010,map00040,map00053,map00071,map00280,map00281,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00626,map00640,map00903,map01100,map01110,map01120 C Aldehyde dehydrogenase COG1012 Cluster_789496 V1276327 S TraX protein 11N9P Cluster_401876 V1276328 DCTP C symporter COG1301 Cluster_534636 V1276329 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0047 Cluster_368700 V1276330 LEXA K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) COG1974 Cluster_661638 V1276331 PSPE P domain protein COG0607 Cluster_338199 V1276332 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_603483 V1276333 YAAA L UPF0246 protein COG3022 Cluster_345808 V1276335 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_518021 V1276336 C Inherit from COG: radical SAM domain protein COG1032 Cluster_339622 V1276338 HUTG map00330,map00340,map01100 E formiminoglutamate hydrolase COG0010 Cluster_770197 V1276339 S PAP2 superfamily 0XZ0P Cluster_339623 V1276340 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_338200 V1276341 S NA 108K1 Cluster_338201 V1276342 map02010 P periplasmic COG0803 Cluster_497270 V1276343 L Integrase COG0582 Cluster_408925 V1276344 CADA P p-type atpase COG2217 Cluster_339624 V1276345 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG1754 Cluster_421622 V1276347 PEPP map00310,map00780,map01100 E peptidase M24 COG0006 Cluster_338202 V1276349 PHBA map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map02020 I acetyl-CoA COG0183 Cluster_576666 V1276350 PEPC E aminopeptidase c COG3579 Cluster_437065 V1276351 DACA map00550,map01100 M carboxypeptidase COG1686 Cluster_520596 V1276352 YADL S Fimbrial protein 17IFJ@proNOG Cluster_738273 V1276353 YADK S fimbrial-like adhesin protein 17HIV@proNOG Cluster_339625 V1276354 OATA I Acyl-transferase COG1835 Cluster_396637 V1276355 FEOB P Ferrous iron transport protein B COG0370 Cluster_341074 V1276356 PBP1A map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_674553 V1276358 RUMG map02010 S Inherit from COG: permease COG4200 Cluster_499938 V1276359 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_339626 V1276360 SERA map00260,map00680,map01100,map01120,map01230 E Dehydrogenase COG0111 Cluster_447128 V1276361 VICX map03013 S domain protein COG1235 Cluster_341075 V1276362 NHAC map00680 C Na H antiporter COG1757 Cluster_341076 V1276363 L site-specific recombinase, phage integrase family 10A1H Cluster_341077 V1276364 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_419822 V1276366 S NA 120CJ Cluster_341078 V1276367 MTNA map00270,map01100 J Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) COG0182 Cluster_762543 V1276368 MENA map00130,map01100,map01110 H 1,4-dihydroxy-2-naphthoate octaprenyltransferase COG1575 Cluster_744968 V1276369 RPLE map03010 J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COG0094 Cluster_678986 V1276370 RPSN map03010 J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) COG0199 Cluster_341079 V1276371 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_368702 V1276373 NADB map00250,map00760,map01100 H L-aspartate oxidase COG0029 Cluster_848265 V1276375 C ferredoxin thioredoxin reductase, catalytic beta chain 0ZDY1 Cluster_480481 V1276376 S NA 0Z5ER Cluster_370408 V1276377 RLUD J pseudouridine synthase COG0564 Cluster_494762 V1276378 S -acetyltransferase 11PF0 Cluster_341080 V1276379 ACDA map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I acyl-Coa dehydrogenase COG2025 Cluster_389509 V1276380 CLPP_1 map04112 O ATP-dependent Clp protease, proteolytic subunit COG0740 Cluster_427214 V1276382 OGT L Methyltransferase COG0350 Cluster_418031 V1276386 YUGP S zinc metallopeptidase COG2738 Cluster_741667 V1276387 TDK map00240,map00983,map01100 F thymidine kinase COG1435 Cluster_482820 V1276388 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_554993 V1276390 LMRA V Abc transporter COG1132 Cluster_429112 V1276391 PDXK map00750,map01100 H Pyridoxal kinase COG2240 Cluster_342594 V1276392 RECT L recT protein COG3723 Cluster_504888 V1276394 C Flavodoxin COG0716 Cluster_762544 V1276395 ETFB map00910 C Electron transfer flavoprotein COG2086 Cluster_342595 V1276396 map02020 T Histidine kinase COG0642 Cluster_342596 V1276397 ICD map00020,map00290,map00480,map00720,map01100,map01110,map01120,map01210,map01230,map04146 C Isocitrate dehydrogenase, NAD-dependent COG0473 Cluster_342597 V1276398 ELI_1296 L Terminase, large subunit COG4626 Cluster_431072 V1276399 DPPB P ABC transporter (Permease COG0601 Cluster_342598 V1276400 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_445069 V1276401 SP_0899 S Membrane Associated 114SZ Cluster_342599 V1276402 MGTE P magnesium transporter COG2239 Cluster_342600 V1276403 S NA 11JWE Cluster_342603 V1276406 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_625667 V1276407 V restriction endonuclease COG4127 Cluster_344197 V1276408 S fad dependent oxidoreductase COG2509 Cluster_437066 V1276411 CKL_2970 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_661639 V1276412 S NA 0ZHU9 Cluster_344198 V1276413 UDK map00240,map00983,map01100 F uridine monophosphokinase COG0572 Cluster_401877 V1276414 YCIT K Transcriptional regulator COG1349 Cluster_344199 V1276415 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_431073 V1276416 map02010 E extracellular ligand-binding receptor COG0683 Cluster_398378 V1276418 S UPF0597 protein COG3681 Cluster_344200 V1276419 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_344201 V1276420 CLFA map05150 M Cell surface-associated protein implicated in virulence. Promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen. Induces formation of bacterial clumps 0Y59N Cluster_391230 V1276421 V Abortive infection bacteriophage resistance protein COG4823 Cluster_478086 V1276422 XFP map00030,map00680,map00710,map01100,map01120 G Phosphoketolase COG3957 Cluster_478087 V1276423 K RNA Polymerase COG1595 Cluster_345809 V1276427 HOM E saf domain-containing protein COG4091 Cluster_549213 V1276428 SUFB O FeS assembly protein SUFB COG0719 Cluster_762545 V1276430 S NA 0ZHU9 Cluster_344202 V1276432 COMM O Mg chelatase subunit ChlI COG0606 Cluster_345810 V1276433 PHNE map02010 P phosphonate abc transporter COG3639 Cluster_852064 V1276436 Y1139 S Membrane 17AFY@proNOG Cluster_599881 V1276437 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_813420 V1276438 HPRK T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) COG1493 Cluster_451119 V1276439 map00061,map00072,map00650,map00780,map01040,map01100 I, Q short-chain dehydrogenase reductase COG1028 Cluster_852065 V1276440 GCVR T UPF0237 protein COG3830 Cluster_443078 V1276441 SP_0239 S UPF0210 protein COG2848 Cluster_344203 V1276442 V ABC transporter transmembrane region 0YGB0 Cluster_344204 V1276443 GLTS E Sodium Glutamate Symporter COG0786 Cluster_518022 V1276444 TELA P Resistance protein COG3853 Cluster_718450 V1276445 S 5-bromo-4-chloroindolyl phosphate hydrolysis protein 111JX Cluster_607101 V1276447 DISA L Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) COG1623 Cluster_614475 V1276448 ISPD map00900,map01100,map01110 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COG1211 Cluster_773901 V1276449 FADB map00071,map00280,map00281,map00310,map00380,map00410,map00640,map00650,map00720,map00903,map00930,map01040,map01100,map01110,map01120,map02020 I Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities (By similarity) COG1250 Cluster_360503 V1276450 POLA_2 L DNA polymerase 0XRUF Cluster_353794 V1276451 map05100 G s-layer domain protein 11IBF Cluster_549214 V1276454 LDH map00010,map00051,map00270,map00363,map00591,map00620,map00625,map00640,map00650,map01100,map01110,map01120 C lactate/malate dehydrogenase, alpha/beta C-terminal domain COG0039 Cluster_531847 V1276455 RPLY map03010 J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) COG1825 Cluster_345811 V1276457 NAGZ3 map00051,map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 G Glycosyl hydrolase family 20, catalytic domain protein COG3525 Cluster_455065 V1276458 S NA 101UU Cluster_345813 V1276461 INTB L Integrase COG0582 Cluster_345814 V1276463 PPSA S pyruvate phosphate dikinase 0XRDW Cluster_586221 V1276464 PANB map00770,map01100,map01110 H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) COG0413 Cluster_641248 V1276465 H NADP oxidoreductase, coenzyme f420-dependent COG5495 Cluster_345815 V1276466 PEPP E peptidase, M24 COG0006 Cluster_507457 V1276467 M transferase COG2148 Cluster_770198 V1276468 S domain protein 0YNW0 Cluster_345816 V1276470 P tonB-dependent Receptor 0ZPJF Cluster_817152 V1276475 RUVX L Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) COG0816 Cluster_692415 V1276476 S conjugative transposon protein 11JUF Cluster_573458 V1276477 S conjugative transposon protein 11GJX Cluster_347410 V1276478 YFCC S c4-dicarboxylate anaerobic carrier COG1288 Cluster_347411 V1276479 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_645133 V1276480 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_583036 V1276481 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_347412 V1276482 V restriction endonuclease COG4127 Cluster_526248 V1276483 RNFD C Electron transport complex COG4658 Cluster_349008 V1276486 S trap transporter, 4tm 12tm fusion protein COG4666 Cluster_433089 V1276489 HLYX P CBS domain protein COG1253 Cluster_360504 V1276490 YDED E, G Membrane COG0697 Cluster_347413 V1276491 MDLA map02010 V ABC transporter transmembrane region COG1132 Cluster_347414 V1276492 CSTA T Carbon starvation protein CstA COG1966 Cluster_349009 V1276493 G Alpha-1,2-mannosidase COG3537 Cluster_687992 V1276494 S NA 0XRT7 Cluster_349010 V1276496 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_370409 V1276497 CINI S Hydrolase COG1073 Cluster_349011 V1276499 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_387783 V1276500 S Protein of unknown function (Porph_ging) 124PH Cluster_349013 V1276502 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_408926 V1276503 DARB map00061,map01100 I synthase III COG0332 Cluster_349014 V1276504 PPK map00190,map03018 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) COG0855 Cluster_725099 V1276506 PTSH G phosphocarrier protein (HPr COG1925 Cluster_579789 V1276507 WHIA K May be required for sporulation (By similarity) COG1481 Cluster_387784 V1276508 BIRA map00780,map01100 H Biotin/lipoate A/B protein ligase family COG1654 Cluster_633198 V1276512 S NA 1246I Cluster_670159 V1276513 S Phage protein Gp19 Gp15 Gp42 126N3 Cluster_350639 V1276514 PHOB map00627,map00790,map01100,map01120,map02020 P alkaline phosphatase COG1785 Cluster_407149 V1276517 BL02070 S synthetase COG2872 Cluster_793288 V1276519 S Membrane COG3949 Cluster_596384 V1276520 S NA 11HZH Cluster_645134 V1276521 RHAB map00040,map00051 G Rhamnulokinase COG1070 Cluster_389510 V1276522 YCXD K Transcriptional regulator, GntR family COG1167 Cluster_718451 V1276525 PFL C formate acetyltransferase COG1882 Cluster_349015 V1276526 RLUD J Pseudouridine synthase COG0564 Cluster_573459 V1276527 PURE map00230,map01100,map01110 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) COG0041 Cluster_352141 V1276529 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_531848 V1276531 S C_GCAxxG_C_C family 11W24 Cluster_408927 V1276532 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_592912 V1276533 YQKD S alpha beta COG1073 Cluster_463172 V1276535 map02020 T Sensor histidine kinase 1254H Cluster_350640 V1276538 RNFB C electron transport complex, RnfABCDGE type, B subunit COG2878 Cluster_350641 V1276539 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_494763 V1276541 S QueT transporter 0XTVI Cluster_489779 V1276543 TRAB S traB family COG1916 Cluster_520597 V1276545 POTB map02010 P ABC transporter, permease COG1176 Cluster_766490 V1276546 POTC map02010 P putrescine abc transporter COG1177 Cluster_471623 V1276547 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_350642 V1276548 PORB map00020,map00720,map01100,map01120 C pyruvate ferredoxin flavodoxin oxidoreductase, beta subunit COG1013 Cluster_583037 V1276553 map00190,map00910,map01100 C hydrogenase) (Fe-only COG4624 Cluster_502473 V1276554 S mj0936 family COG0622 Cluster_546180 V1276555 UUP S Abc transporter COG0488 Cluster_708639 V1276556 REX K Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) COG2344 Cluster_360505 V1276558 PAGL map00010 G glycoside hydrolase family 4 COG1486 Cluster_352143 V1276563 L Inherit from COG: transposase COG3666 Cluster_741668 V1276564 S NA 0YNQF Cluster_653310 V1276566 map00052,map00520,map01100,map01110 G, M epimerase COG0451 Cluster_352144 V1276567 S NA 0YEUF Cluster_352145 V1276569 AROG map00400,map01100,map01110,map01230 E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) COG0722 Cluster_421623 V1276572 DPPC P ABC transporter permease protein COG1173 Cluster_352146 V1276573 PPNK map00760,map01100 G Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) COG0061 Cluster_353796 V1276574 UXUA map00040,map01100 G Catalyzes the dehydration of D-mannonate (By similarity) COG1312 Cluster_405489 V1276575 LDTA S ErfK YbiS YcfS YnhG COG1376 Cluster_618227 V1276576 map00790,map01100 S 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase 12BSQ Cluster_353797 V1276577 S solute-binding protein 0XPXC Cluster_353798 V1276579 D ec 3.6.3.16 COG0003 Cluster_353799 V1276580 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_497271 V1276583 RSMG M Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) COG0357 Cluster_353800 V1276585 HLYX P CBS domain protein COG1253 Cluster_801220 V1276591 YAAA S s4 domain protein COG2501 Cluster_478089 V1276592 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_473715 V1276596 NAGA map00052,map00520,map01110 G GlcNAc 6-P deacetylase COG1820 Cluster_353801 V1276598 PYCB map00330,map00620,map01100 C Oxaloacetate decarboxylase COG5016 Cluster_355473 V1276599 BMUL_2073 K repressor COG1609 Cluster_531849 V1276600 THID map00730,map01100 H phosphomethylpyrimidine kinase COG0351 Cluster_728426 V1276601 T phosphohistidine phosphatase, SixA COG2062 Cluster_433090 V1276602 APPB E, P ABC transporter, permease protein COG0601 Cluster_579790 V1276603 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG0194 Cluster_718452 V1276605 S NA 0Y4PD Cluster_766491 V1276606 S Inherit from NOG: Plasmid segregation actin-type ATPase ParM 0XQMS Cluster_353803 V1276607 GDHA map00250,map00330,map00910,map01100 E Glutamate dehydrogenase COG0334 Cluster_649231 V1276608 map00561,map01100 G DAK2 domain protein COG2376 Cluster_625668 V1276609 map00561,map00680,map01100,map01120,map04622 G Dihydroxyacetone kinase COG2376 Cluster_487436 V1276610 THIH map00730,map01100 H biosynthesis protein thiH COG1060 Cluster_355474 V1276612 PACL P p-type ATPase COG0474 Cluster_355475 V1276613 ACRA6 V efflux transporter, rnd family, mfp subunit COG0845 Cluster_363647 V1276614 RRGB M Lpxtg-motif cell wall anchor domain protein 0XSEP Cluster_355476 V1276615 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_355477 V1276616 P cation diffusion facilitator family transporter COG0053 Cluster_355478 V1276617 S NA 0ZTYV Cluster_362079 V1276618 MTAD F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) COG0402 Cluster_355479 V1276620 ROCB E peptidase, M20 COG4187 Cluster_805391 V1276621 PURA map00230,map00250,map01100 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis COG0104 Cluster_515352 V1276625 S NA 0ZXT9 Cluster_579791 V1276626 P hemerythrin hhe cation binding domain protein COG2461 Cluster_416230 V1276627 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_355480 V1276628 BIOB map00780,map01100 H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) COG0502 Cluster_355481 V1276629 S Domain-Containing protein 0XS46 Cluster_510051 V1276631 ARGC map00330,map01100,map01110,map01210,map01230 E N-acetylglutamate semialdehyde dehydrogenase COG0002 Cluster_868157 V1276632 map00350,map00362,map00627,map00642,map00903,map01120 S acetyltransferase, (GNAT) family COG0456 Cluster_599882 V1276633 map02010 G NA 10Q7N Cluster_355482 V1276634 BA_0233 E, P ABC transporter, permease protein COG1173 Cluster_357181 V1276635 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_357182 V1276636 HUTI Q amidohydrolase COG1228 Cluster_518024 V1276637 MSRA O reductase COG0229 Cluster_766492 V1276640 map02010 P Periplasmic binding protein 0XRC7 Cluster_543249 V1276641 map02010 P Iron chelate uptake ABC transporter, FeCT family, permease protein COG0609 Cluster_355483 V1276642 map02010 P Periplasmic binding protein 0XRC7 Cluster_357183 V1276644 ILVD map00290,map00770,map01100,map01110,map01210,map01230 E, G Dihydroxy-acid dehydratase COG0129 Cluster_357184 V1276645 APEB E M18 family aminopeptidase COG1362 Cluster_751761 V1276646 S prevent-host-death family 124KH Cluster_357185 V1276647 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_357186 V1276649 ALST E amino acid carrier protein COG1115 Cluster_529005 V1276650 BCELL_1025 L Integrase COG2801 Cluster_357187 V1276651 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_357188 V1276652 YXCA I coA-substrate-specific enzyme activase COG3581 Cluster_408928 V1276653 RLUD J Pseudouridine synthase COG0564 Cluster_469465 V1276654 MUTF map02010 V ABC transporter, ATP-binding protein COG1131 Cluster_357189 V1276655 PPK map00190,map03018 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) COG0855 Cluster_467347 V1276658 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG2812 Cluster_702461 V1276659 S NA 0Y12I Cluster_715195 V1276660 L NA 0YKV1 Cluster_465256 V1276662 PPAC map00190 C Manganese-dependent inorganic pyrophosphatase COG1227 Cluster_457009 V1276663 MURE map00300,map00550 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_358826 V1276665 map05100 G s-layer domain protein 11IBF Cluster_358827 V1276666 YLOV S dak2 domain fusion protein ylov COG1461 Cluster_358828 V1276667 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0691 Cluster_358829 V1276668 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_358830 V1276669 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_414453 V1276670 V restriction 174SY@proNOG Cluster_458989 V1276673 V MatE COG0534 Cluster_358831 V1276674 ISDE map02010 P periplasmic binding protein COG0614 Cluster_358832 V1276676 map00010,map00030,map00051,map00052,map00680,map00710,map01100,map01110,map01120,map01230 G Aldolase COG0191 Cluster_425273 V1276677 MGTE P magnesium transporter COG2239 Cluster_900922 V1276678 map03420,map03430 L helicase COG0210 Cluster_358833 V1276679 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_358834 V1276680 S domain protein 0ZK4G Cluster_358835 V1276681 ABPB map00310,map00780,map01100 E Dipeptidase COG4690 Cluster_560963 V1276682 YQGX map00620 Q domain protein COG0491 Cluster_358836 V1276684 F ATP cone domain COG1328 Cluster_407150 V1276687 ACDA map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I acyl-CoA dehydrogenase COG2025 Cluster_467348 V1276688 DEF J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) COG0242 Cluster_358837 V1276689 LEUA map00290,map00620,map01100,map01110,map01210,map01230 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) COG0119 Cluster_888335 V1276690 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_512631 V1276691 DPPA E Extracellular solute-binding protein, family 5 COG0747 Cluster_478090 V1276693 F Phosphorylase superfamily COG0775 Cluster_515353 V1276694 ASD map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) COG0136 Cluster_358838 V1276696 S NA 11NI8 Cluster_534637 V1276697 USPA T Universal stress protein A COG0589 Cluster_358839 V1276698 P permease COG0628 Cluster_358841 V1276702 L Phage stabilisation protein 16YNR@proNOG Cluster_358842 V1276703 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_360506 V1276704 ADCA map02010 P periplasmic solute binding protein COG0803 Cluster_394860 V1276705 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_360507 V1276706 THYA map00240,map00670,map01100 F Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) COG0207 Cluster_429113 V1276709 RPLJ map03010 J 50s ribosomal protein L10 COG0244 Cluster_377148 V1276710 S oxidoreductase Domain protein COG0673 Cluster_573460 V1276711 CSE4 L Crispr-associated protein, cse4 family 0Y6PV Cluster_453050 V1276712 V Mate efflux family protein COG0534 Cluster_637250 V1276713 RPLV map03010 J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) COG0091 Cluster_758727 V1276714 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_518025 V1276716 FABG map00061,map00780,map01040,map01100 S 3-oxoacyl- acyl-carrier-protein reductase 0XNW1 Cluster_360508 V1276717 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_785491 V1276718 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_649232 V1276719 GLPE map00270,map01100,map04122 P Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) COG0607 Cluster_809421 V1276720 M Outer membrane protein, OMP85 family 0XNPU Cluster_573461 V1276721 RPSB map03010 J 30S ribosomal protein S2 COG0052 Cluster_801223 V1276723 F nucleoside COG3613 Cluster_607102 V1276724 S Ser Thr phosphatase family protein COG1408 Cluster_362081 V1276725 PPK map00190,map03018 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) COG0855 Cluster_552104 V1276726 S NA 0Y99D Cluster_360509 V1276729 SECA2 map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_475885 V1276730 D Chromosome partitioning COG1192 Cluster_389511 V1276731 ASPA map00250,map00910,map01100 E Aspartate ammonia-lyase COG1027 Cluster_423476 V1276733 GLTS E Sodium Glutamate Symporter COG0786 Cluster_362082 V1276735 BCRA map02010 V ABC transporter COG1131 Cluster_718453 V1276736 PTSH map02060 G PHOSPHOCARRIER protein COG1925 Cluster_840344 V1276737 S Toxin-antitoxin system, toxin component, RelE family 0XTKQ Cluster_360510 V1276738 FRYA map00051,map01100,map02060 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) COG1925 Cluster_360511 V1276739 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_360512 V1276740 F ATP cone domain COG1328 Cluster_360513 V1276742 SP_0239 S UPF0210 protein COG2848 Cluster_362083 V1276743 P TonB-dependent Receptor Plug Domain 0YD5U Cluster_362084 V1276744 T response regulator COG2208 Cluster_362085 V1276745 DNAQ map03022,map03420 L helicase COG1199 Cluster_385979 V1276746 NASD map00910,map01120 C nitrite reductase, (NAD(P)H) COG1251 Cluster_725100 V1276751 VEG S Veg protein COG4466 Cluster_469466 V1276752 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_362087 V1276753 S phage protein 0XQDU Cluster_696146 V1276754 S NA 11US1 Cluster_629363 V1276755 S DeoR-like helix-turn-helix domain 11J12 Cluster_473716 V1276756 V ABC transporter COG1132 Cluster_363648 V1276758 M domain protein COG4932 Cluster_433091 V1276759 CTPC map00190 P heavy metal translocating P-type ATPase COG2217 Cluster_489780 V1276760 MURE map00300,map00550,map01100 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_362088 V1276761 S Inherit from NOG: repeat protein 11TEE Cluster_441075 V1276762 map00020,map00190,map00623,map00650,map00720,map00984,map01100,map01110,map01120,map02020 C Flavocytochrome c COG1053 Cluster_363649 V1276765 map00280,map00362,map00650,map01100,map01120 I glutaconyl-CoA decarboxylase COG4799 Cluster_529007 V1276767 FBP map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120 G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 COG3855 Cluster_363650 V1276768 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_520598 V1276769 S NA 122HI Cluster_793290 V1276770 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_603484 V1276771 RBFA J Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) COG0858 Cluster_864200 V1276774 APBE H ApbE family COG1477 Cluster_363651 V1276775 RBN S UPF0761 membrane protein COG1295 Cluster_423477 V1276776 CSE4 L Crispr-associated protein, cse4 family 0Y6PV Cluster_363652 V1276777 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_443079 V1276778 SMTA map00340,map00350,map00624,map01120 J Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) COG4123 Cluster_482821 V1276780 map02020 T response regulator COG2197 Cluster_363654 V1276782 map02010 E PBPb COG0834 Cluster_637251 V1276784 S NA 11SJR Cluster_365386 V1276787 P Cation transporting ATPase, C-terminus COG0474 Cluster_482822 V1276789 S NA 11VIE Cluster_489781 V1276790 GREA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) COG0782 Cluster_363656 V1276792 VIRB5 map03070 U type IV secretion system 17F2B@proNOG Cluster_596385 V1276793 DGKA map00561,map00564,map01100,map04070 M Diacylglycerol kinase COG0818 Cluster_674554 V1276794 CDD map00240,map00983,map01100,map05219 F cytidine deaminase COG0295 Cluster_365387 V1276795 V T5orf172 0XQ8K Cluster_363657 V1276796 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_748317 V1276799 NINE S Protein NinE homolog from lambdoid prophage DLP12 1873U@proNOG Cluster_699423 V1276800 YBCO S Protein of unknown function (DUF1364) 17H44@proNOG Cluster_373663 V1276801 PFLX S radical SAM domain protein COG1313 Cluster_586222 V1276802 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_523336 V1276803 TRMFO J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) COG1206 Cluster_482823 V1276805 MGTC S MgtC SapB transporter COG1285 Cluster_614477 V1276806 S NA 0Y46D Cluster_744970 V1276807 L Addiction module antitoxin, RelB DinJ family COG3077 Cluster_365388 V1276808 FBP map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120 G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 COG3855 Cluster_653311 V1276810 STP T Phosphatase COG0631 Cluster_625669 V1276811 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_429114 V1276813 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_365389 V1276814 ATPA map00190,map00195,map01100,map04610,map05202 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_365390 V1276816 ASTA S Arylsulfotransferase 174ZE@proNOG Cluster_365391 V1276817 N repeat protein 11QCF Cluster_396638 V1276818 E, G EamA-like transporter family COG0697 Cluster_365392 V1276820 YPO3839 E UPF0261 protein COG5441 Cluster_367076 V1276821 DEOA map00240,map00983,map01100,map05219 F The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) COG0213 Cluster_441076 V1276822 FNI map00900,map01100,map01110 C Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) COG1304 Cluster_365393 V1276823 LPDA map00010,map00020,map00260,map00280,map00620,map01100,map01110,map01120 C Dihydrolipoyl dehydrogenase COG1249 Cluster_365394 V1276824 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_599883 V1276825 map00051,map00363,map00591,map00625,map00650,map01100,map01120 S Nadph-dependent fmn reductase COG0431 Cluster_567138 V1276826 HYFH map00190,map01100 C formate hydrogenlyase complex iron-sulfur subunit COG1143 Cluster_708640 V1276827 HYFI C NADH ubiquinone oxidoreductase 20 kda subunit COG3260 Cluster_367077 V1276829 FTSK D cell division protein FtsK COG1674 Cluster_567139 V1276830 FUCA map00051 G Class II aldolase adducin family protein COG0235 Cluster_715197 V1276833 YEEW S NA 17I6N@proNOG Cluster_821031 V1276835 K Transcriptional regulator 0XWJY Cluster_396639 V1276839 ISPE map00900,map01100,map01110 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COG1947 Cluster_367079 V1276840 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_777592 V1276841 YJJP S Membrane COG2966 Cluster_510052 V1276842 S integral membrane protein COG3610 Cluster_429115 V1276843 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_670161 V1276844 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_661640 V1276845 PSTB2 map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_447130 V1276847 S haloacid dehalogenase-like hydrolase 11M2Z Cluster_367080 V1276848 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_419823 V1276849 S transglutaminase domain-containing protein 0XQP2 Cluster_510053 V1276851 S HIRAN domain 0XVUM Cluster_367081 V1276853 GDH map00250,map00330,map00910,map01100 E Glutamate dehydrogenase COG0334 Cluster_708641 V1276854 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_367082 V1276856 MPRF map05150 J Membrane COG2898 Cluster_367083 V1276857 SUFB O FeS assembly protein SUFB COG0719 Cluster_576668 V1276858 RPLC map03010 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 Cluster_384199 V1276859 S NA 11HQM Cluster_368703 V1276861 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_543250 V1276862 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_872157 V1276863 CAT1 map00281,map00620,map00626,map01110,map01120 C Transferase COG0427 Cluster_403667 V1276865 DXS map00730,map00900,map01100,map01110 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) COG1154 Cluster_670162 V1276868 S NA 11R1Y Cluster_367084 V1276870 PARE L DNA topoisomerase IV (Subunit B) COG0187 Cluster_852068 V1276871 S esterase 1294K Cluster_489782 V1276872 S NA 11H00 Cluster_391231 V1276873 GCDB map00330,map00362,map00620,map00650,map01100,map01120 C decarboxylase (Beta subunit) COG1883 Cluster_368704 V1276874 COMEC S DNA internalization-related competence protein ComEC Rec2 COG2333 Cluster_367085 V1276876 S NA 0XSI9 Cluster_441077 V1276877 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_451120 V1276878 GUAD map00230,map01100 F Guanine deaminase COG0402 Cluster_777593 V1276879 map00340,map00350,map00624,map01120 Q O-Methyltransferase COG0500 Cluster_526249 V1276880 DARC1 S Flexirubin-type pigment biosynthesis acyl carrier protein 11XV7 Cluster_797252 V1276881 YJGR S ATP-binding protein COG0433 Cluster_368705 V1276882 APPA E Extracellular solute-binding protein, family 5 COG0747 Cluster_368706 V1276883 ANSA map00250,map00460,map00910,map01100,map01110 E L-asparaginase COG0252 Cluster_596386 V1276885 BL02952 S Membrane COG1434 Cluster_410770 V1276888 I Lipid kinase, YegS Rv2252 BmrU family COG1597 Cluster_665853 V1276889 S conserved protein domain typically associated with flavoprotein COG1853 Cluster_370410 V1276890 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_368707 V1276891 G Alpha-1,2-mannosidase COG3537 Cluster_368708 V1276892 PRIA map03440 L Primosomal protein n' COG1198 Cluster_368709 V1276893 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_368710 V1276894 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0587 Cluster_368711 V1276895 L integrase family 0XRS7 Cluster_368712 V1276896 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_480482 V1276897 THIN map00730,map01100 H thiamine COG1564 Cluster_368713 V1276900 CPN_0573 K transcriptional regulatory protein COG0217 Cluster_372039 V1276902 NAGH map00051,map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 G hydrolase family 20, catalytic COG3525 Cluster_825001 V1276904 GEOTH_0480 L Integrase catalytic subunit COG4584 Cluster_475886 V1276905 CORA P transporter COG0598 Cluster_828793 V1276907 P Rhodanese-like domain COG0607 Cluster_563940 V1276908 P faD-dependent pyridine nucleotide-disulfide oxidoreductase COG0607 Cluster_368714 V1276909 S gtp-binding protein COG3596 Cluster_368715 V1276911 FNI map00900,map01100,map01110 C Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) COG1304 Cluster_603485 V1276913 S Pentapeptide repeat 11KS3 Cluster_425274 V1276914 map03420,map03430 S UvrD/REP helicase N-terminal domain 17BUF@proNOG Cluster_540321 V1276915 INFC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) COG0290 Cluster_473718 V1276919 S NA 102RM Cluster_758728 V1276920 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate (By similarity) COG0167 Cluster_629365 V1276921 ARSC P Transcriptional regulator, Spx MgsR family COG1393 Cluster_570227 V1276925 CCPN K (CBS) domain COG0517 Cluster_836414 V1276926 S Phenazine biosynthesis protein, PhzF family COG0384 Cluster_499939 V1276927 YIHY S ribonuclease BN COG1295 Cluster_570228 V1276928 U Conjugal transfer protein 10082 Cluster_821033 V1276929 S NA 0ZAAF Cluster_372040 V1276930 PARE L DNA topoisomerase IV, subunit B COG0187 Cluster_586223 V1276932 S NA 0YJ27 Cluster_699424 V1276933 LDHA map00260,map00620,map00630,map00680,map01100,map01110,map01120 C Dehydrogenase COG1052 Cluster_372041 V1276934 YPHG S repeat protein 0Z39P Cluster_373664 V1276935 U relaxase mobilization nuclease domain protein COG3843 Cluster_370411 V1276936 RFAB map00540,map01100 M Glycosyl transferase (Group 1 COG0438 Cluster_370412 V1276937 K Transcriptional Regulator AraC Family 0ZYR5 Cluster_393041 V1276938 HPPA map00190 C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for COG3808 Cluster_408929 V1276940 POTB map02010 P ABC transporter, permease COG1176 Cluster_370414 V1276944 K Transcriptional Regulator AraC Family COG2207 Cluster_629366 V1276945 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_661641 V1276946 CBPA O DnaJ domain protein COG2214 Cluster_583038 V1276947 THYX map00240,map00340,map00350,map00624,map00670,map01120 F Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) COG1351 Cluster_439083 V1276948 NUDF map00230 F nudix hydrolase COG0494 Cluster_372042 V1276950 THIC map00730,map01100 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) COG0422 Cluster_372043 V1276951 METN map02010 P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COG1135 Cluster_465257 V1276952 S Phenazine biosynthesis protein, PhzF family COG0384 Cluster_670163 V1276954 FLGJ map00511 N, U flagellar rod assembly protein muramidase flgj COG1705 Cluster_758729 V1276957 map00362,map01100,map01120 C Hydrolase COG0596 Cluster_781406 V1276959 DACB M carboxypeptidase COG1876 Cluster_372044 V1276960 VPA1266 map03440 L Helicase, RecD TraA family COG4932 Cluster_770202 V1276961 RIBU S Membrane COG3601 Cluster_599884 V1276962 S copper amine 121X1 Cluster_391232 V1276963 S Inherit from COG: LOR SDH bifunctional protein conserved domain protein COG1915 Cluster_372045 V1276964 V Mate efflux family protein COG0534 Cluster_410771 V1276965 Y2679 M domain protein COG3515 Cluster_373665 V1276966 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_373666 V1276967 FEOB P Ferrous iron transport protein B COG0370 Cluster_387785 V1276970 RNFB C electron transport complex, RnfABCDGE type, B subunit COG2878 Cluster_649234 V1276971 PADR K Transcriptional regulator COG1695 Cluster_372046 V1276972 V abc transporter permease protein 0ZW5X Cluster_373667 V1276973 S fad dependent oxidoreductase COG2509 Cluster_373668 V1276974 S NA 101MB Cluster_502474 V1276975 YGDL H uba thif-type nad fad binding protein COG1179 Cluster_762546 V1276976 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_373669 V1276978 M mechanosensitive ion channel (MscS) COG3264 Cluster_373670 V1276982 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_614478 V1276983 E, G Membrane COG0697 Cluster_373671 V1276986 GLGA map00500,map01100,map01110,map04973 G Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) COG0297 Cluster_414454 V1276987 DXS map00730,map00900,map01100,map01110 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) COG1154 Cluster_497272 V1276989 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01230 G phosphohexose isomerase COG0166 Cluster_410772 V1276990 S nucleoside recognition domain protein COG3314 Cluster_855841 V1276991 S NA 0XPTV Cluster_592913 V1276992 C aldo keto reductase COG0667 Cluster_375372 V1276993 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_407151 V1276994 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_373672 V1276996 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_375373 V1276998 L Resolvase COG1961 Cluster_375374 V1276999 S transposon TraJ 0YBFN Cluster_592914 V1277000 NHAC map00680 C Na H antiporter COG1757 Cluster_458990 V1277001 L Transposase COG0675 Cluster_458991 V1277002 S Protein of unknown function (DUF2589) 11QMM Cluster_393042 V1277004 S relaxase mobilization nuclease domain protein 0XNXG Cluster_373673 V1277005 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_445071 V1277006 S major tail protein, phi13 family 11ICY Cluster_414455 V1277007 MDLA V Abc transporter COG1132 Cluster_373674 V1277010 HOM E saf domain-containing protein COG4091 Cluster_567140 V1277014 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_375377 V1277017 GLNN map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG3968 Cluster_554996 V1277020 S NA 0ZWKI Cluster_453051 V1277021 C symporter COG1301 Cluster_427215 V1277022 AVTA map00300,map01100,map01210,map01230 E, K Aminotransferase, class I II COG1167 Cluster_375378 V1277023 CTPA M Peptidase, S41 family COG0793 Cluster_375379 V1277024 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_451121 V1277025 map00362,map01100,map01120 C Hydrolase COG0596 Cluster_848268 V1277026 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_801226 V1277027 K HTH_XRE 0XUC3 Cluster_785492 V1277028 S NA 0YRPX Cluster_485134 V1277031 CODA map00240,map00330,map00791,map01100,map01120 F cytosine deaminase COG0402 Cluster_469467 V1277032 PATB map00270,map00450,map00920,map01100,map01110,map01230 E Aminotransferase class I and II COG1168 Cluster_407152 V1277033 HK09 map02020 T Histidine kinase COG2972 Cluster_434996 V1277035 YNBB map00260,map00270,map00450,map01100,map01230 P aluminum resistance protein COG4100 Cluster_375381 V1277036 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_375382 V1277037 ATPB map00190,map00195,map01100 C it plays a direct role in the translocation of protons across the membrane (By similarity) COG0356 Cluster_453052 V1277038 S Aminoglycoside phosphotransferase 0XP56 Cluster_375383 V1277040 L helicase domain protein COG0553 Cluster_375384 V1277041 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_751762 V1277042 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_596387 V1277043 S NA 121QQ Cluster_515354 V1277046 PPAC map00190 C Manganese-dependent inorganic pyrophosphatase COG1227 Cluster_567141 V1277047 RPSK map03010 J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) COG0100 Cluster_377149 V1277050 S tetratricopeptide 0XQVJ Cluster_375385 V1277051 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0587 Cluster_552105 V1277052 S NA 101MB Cluster_896583 V1277053 S NA 11K4P Cluster_434997 V1277054 S Kelch repeat type 1-containing protein 17PBD@proNOG Cluster_375386 V1277055 ATP2C1 P p-type ATPase COG0474 Cluster_377150 V1277057 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_540322 V1277058 RPLQ map03010 J 50S ribosomal protein l17 COG0203 Cluster_721755 V1277059 map02010 P Permease protein COG0609 Cluster_573462 V1277060 FECE map02010 P ABC transporter COG1120 Cluster_377151 V1277061 SP_1328 E sodium solute COG0591 Cluster_377152 V1277062 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_421624 V1277064 METB map00270,map00450,map00920,map01100,map01110,map01230 E cystathionine COG0626 Cluster_579793 V1277065 S NA 0ZW55 Cluster_725102 V1277066 K Transcriptional regulator 0XTMY Cluster_377154 V1277067 LACG map00052,map01100 G Glycosyl hydrolase family 1 COG2723 Cluster_377155 V1277068 CINA H competence damage-inducible protein COG1546 Cluster_378930 V1277070 TYPA T gtp-binding protein typa COG1217 Cluster_552106 V1277071 MURI map00471,map01100 M Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) COG0796 Cluster_401878 V1277072 S NA 0Y0CD Cluster_377156 V1277073 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_423478 V1277075 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_728429 V1277076 VEG S Veg protein COG4466 Cluster_699426 V1277077 ISPE map00900,map01100,map01110 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COG1947 Cluster_377157 V1277078 DPPD map02010 S ABC transporter COG1123 Cluster_378931 V1277079 S NA 0YKBK Cluster_378932 V1277080 S NA 10WT0 Cluster_377158 V1277081 LIGB map03030,map03410,map03420,map03430 L Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) COG0272 Cluster_378933 V1277084 PABB map00790 E synthase component I COG0147 Cluster_596388 V1277085 DDAH E dimethylaminohydrolase COG1834 Cluster_805393 V1277086 LYSI E Arginine ornithine antiporter COG0531 Cluster_687993 V1277090 YIDP K GntR family transcriptional regulator COG2188 Cluster_378934 V1277091 SURB S G5 domain protein 0ZVV3 Cluster_378935 V1277093 TRWF map03070 U Conjugal transfer protein trbG COG3504 Cluster_382425 V1277094 SSCG_03340 S Membrane COG2860 Cluster_489783 V1277095 DGOD map00052 G Galactonate dehydratase COG4948 Cluster_412593 V1277096 S Chromosome segregation ATPase 0XP5N Cluster_378936 V1277097 map02010 V ABC-2 type transporter COG0842 Cluster_378937 V1277098 FUCO map00620,map00630,map01120 C lactaldehyde reductase COG1454 Cluster_378938 V1277101 PFLB map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_378939 V1277102 BA_1953 map00363,map00960,map01120 S alpha beta 11FW9 Cluster_400091 V1277103 S Auxin Efflux Carrier COG0679 Cluster_387786 V1277104 HCP C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) COG1151 Cluster_378940 V1277105 RNHB map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0164 Cluster_502475 V1277106 HCP5 S Protein of unknown function (DUF796) 17A66@proNOG Cluster_380650 V1277107 NHAC-1 map00680 C Na H antiporter COG1757 Cluster_523337 V1277108 FECD map02010 P ABC superfamily ATP binding cassette transporter membrane protein COG0609 Cluster_797253 V1277110 GLNP E amino acid AbC transporter COG0765 Cluster_687994 V1277111 ARTM2 E amino acid AbC transporter COG0765 Cluster_549215 V1277113 YHCG V abc transporter atp-binding protein COG1131 Cluster_378941 V1277115 AMYA map00500,map01100,map04973 G Alpha-amylase COG0366 Cluster_567142 V1277117 METQ map02010 P (Lipo)protein COG1464 Cluster_825004 V1277118 UPP map00240,map01100 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) COG0035 Cluster_380651 V1277119 P abc transporter permease protein 0ZFR9 Cluster_475887 V1277120 SELD map00450,map01100 E Synthesizes selenophosphate from selenide and ATP (By similarity) COG0709 Cluster_380652 V1277122 HEMC map00860,map01100,map01110 H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) COG0181 Cluster_380653 V1277123 KDGK map00030,map00040,map01100,map01120 G pfkb domain protein COG0524 Cluster_380654 V1277125 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_380655 V1277126 LACE map00052,map01100,map02060 G pts system, lactose-specific COG1455 Cluster_489784 V1277127 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_378942 V1277128 map03420 K, L transcription-repair coupling factor COG1197 Cluster_380656 V1277130 M Cell wall anchor domain protein 129AF Cluster_378943 V1277131 AHPF O Alkyl hydroperoxide reductase COG3634 Cluster_478091 V1277132 F Permease family COG2233 Cluster_560964 V1277133 L Resolvase N-terminal domain protein 0YDPZ Cluster_641251 V1277135 V Hnh endonuclease COG1403 Cluster_401879 V1277137 S gp37gp68 family COG4422 Cluster_380657 V1277139 CYDC map02010 V Abc transporter COG1132 Cluster_382427 V1277140 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_380658 V1277143 LICD M licD family COG3475 Cluster_534638 V1277144 NTPC map00190,map00680,map01100 C ATP synthase subunit C COG1527 Cluster_721756 V1277145 S GSCFA domain protein 0YSVQ Cluster_711838 V1277147 S NA 11KRP Cluster_592915 V1277148 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_821034 V1277149 NIKB map02010 P Nickel transporter permease NikB COG0601 Cluster_554997 V1277150 NUDF map00230 F nudix hydrolase COG0494 Cluster_382429 V1277151 BPET1060 L DNA polymerase COG3344 Cluster_518026 V1277152 ISPE map00900,map01100,map01110 I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) COG1947 Cluster_419824 V1277153 XPT map00230,map01100,map01110 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) COG0503 Cluster_825005 V1277154 S NA 0XYSK Cluster_721757 V1277155 L resolvase COG1961 Cluster_380659 V1277158 S NA 11TYD Cluster_380660 V1277159 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_382431 V1277162 S tail tape measure protein COG5280 Cluster_382432 V1277163 M domain protein COG4932 Cluster_455066 V1277164 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_393043 V1277166 S Protein of unknown function (DUF3160) 0XRJH Cluster_461059 V1277167 DPPB P transporter permease protein COG0601 Cluster_696150 V1277168 L transposase 1728V@proNOG Cluster_876265 V1277169 RPST map03010 J Binds directly to 16S ribosomal RNA (By similarity) COG0268 Cluster_629367 V1277170 TRKA P potassium transporter peripheral membrane COG0569 Cluster_427216 V1277174 T response regulator COG0745 Cluster_434998 V1277175 MUTL map03430 L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) COG0323 Cluster_586224 V1277176 QUEE map00790,map01100 H Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) COG0602 Cluster_478092 V1277177 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_510054 V1277178 LACR K DeoRC COG1349 Cluster_382434 V1277180 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_758730 V1277181 UDK map00240,map00710,map00983,map01100,map01120 F uridine monophosphokinase COG0572 Cluster_382435 V1277183 SRTB U sortase, SrtB family COG4509 Cluster_384200 V1277186 S Protein of unknown function (DUF1524) COG3586 Cluster_384201 V1277187 ETFA map00910 C Electron transfer flavoprotein COG2025 Cluster_382437 V1277189 MUTS2 map03430 L muts2 protein COG1193 Cluster_382438 V1277190 OPPF2 map02010 E (ABC) transporter COG4608 Cluster_520599 V1277192 BPR_I0156 L transposase COG1943 Cluster_408930 V1277193 PHNB map02010 P phosphonate abc transporter COG3639 Cluster_699427 V1277194 RIMM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) COG0806 Cluster_773906 V1277195 S NA 0ZYSR Cluster_900924 V1277196 RPSP map03010 J 30s ribosomal protein S16 COG0228 Cluster_382439 V1277197 UGPB map02010 G extracellular solute-binding protein family 1 COG1653 Cluster_382440 V1277198 LACD map00052,map01100 G Aldolase COG3684 Cluster_382441 V1277199 SP_1282 S abc transporter atp-binding protein COG0488 Cluster_412595 V1277200 HEMN map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_821035 V1277202 LUXS map00270,map05111 T Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) COG1854 Cluster_429116 V1277203 PCRA map03420,map03430 L helicase COG0210 Cluster_563941 V1277205 YCHF J gtp-binding protein COG0012 Cluster_416231 V1277206 ARSB P arsenicaL-resistance protein COG0798 Cluster_384202 V1277207 PEPS E aminopeptidase COG2309 Cluster_499941 V1277208 Q methyltransferase COG0500 Cluster_661642 V1277209 S Membrane 125HS Cluster_384203 V1277210 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_607103 V1277211 S NA 1265H Cluster_705565 V1277212 S NA 0YK6Z Cluster_770203 V1277214 SGCA map00051,map00053,map01100,map01120,map02060 G IIa component COG1762 Cluster_649236 V1277215 ULAA map00053,map01100,map01120,map02060 G PTS system ascorbate-specific transporter subunit IIC COG3037 Cluster_384204 V1277217 UDK map00240,map00710,map00983,map01100,map01120 F uridine monophosphokinase COG0572 Cluster_396640 V1277218 S Membrane COG1811 Cluster_705566 V1277219 M Glycosyl transferase (Group 1 0XSCX Cluster_603487 V1277220 M group 2 family COG0463 Cluster_384205 V1277221 METY map00270,map00450,map00920,map01100,map01110,map01230 E Cys/Met metabolism PLP-dependent enzyme COG2873 Cluster_418032 V1277222 CBIX map00860,map01100 S cobalamin (vitamin b12) biosynthesis cbix protein 0XS6H Cluster_529008 V1277224 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_385980 V1277226 SPPA O, U Signal peptide peptidase, SppA COG0616 Cluster_599885 V1277229 CUTA S divalent ion tolerance protein COG3323 Cluster_579794 V1277233 YFMR S abc transporter COG0488 Cluster_389513 V1277234 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0470 Cluster_492276 V1277236 RIMM J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) COG0806 Cluster_909286 V1277237 TRMD map00900,map01100,map01110 J Specifically methylates guanosine-37 in various tRNAs (By similarity) COG0336 Cluster_443080 V1277238 YABB map00340,map00350,map00624,map01120 L Methyltransferase COG4123 Cluster_385981 V1277239 HCAN_0528 V Type I restriction modification DNA specificity domain COG0732 Cluster_384207 V1277240 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_531851 V1277241 L NA 0YJFA Cluster_385982 V1277242 MRDB M Rod shape-determining protein rodA COG0772 Cluster_385983 V1277244 S FN3 0ZU8F Cluster_504889 V1277246 FTSW map04112 D Cell division protein FtsW COG0772 Cluster_384208 V1277247 S Inherit from NOG: Histidine triad protein 11G35 Cluster_492277 V1277248 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_385984 V1277250 ILYOP_1739 map00260,map01100 C pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_423479 V1277252 S conjugation system ATPase, TraG family 0XSHU Cluster_398379 V1277254 SLGD_00064 map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_702464 V1277255 RNFE C Electron transport complex COG4660 Cluster_387787 V1277258 SERA map00260,map00680,map01100,map01120,map01230 E, H Dehydrogenase COG0111 Cluster_465258 V1277260 M NA 0ZY8Y Cluster_385985 V1277261 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_385986 V1277262 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_661643 V1277263 E, G permease COG0697 Cluster_387788 V1277265 S NA 11F7I Cluster_387789 V1277267 PURA map00230,map00250,map01100 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis COG0104 Cluster_387790 V1277268 TOPB L Dna topoisomerase COG0550 Cluster_414456 V1277269 SUCC map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120 C Succinyl-CoA synthetase subunit beta COG0045 Cluster_840347 V1277272 YHFE E m42 family COG1363 Cluster_512632 V1277274 MREC M Involved in formation and maintenance of cell shape (By similarity) COG1792 Cluster_463173 V1277275 ILVA map00260,map00290,map01100,map01110,map01230 E Threonine dehydratase COG1171 Cluster_387791 V1277276 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_570229 V1277278 SMP S Membrane COG3726 Cluster_387792 V1277279 DAM map03430 L Dna adenine methylase COG0338 Cluster_387793 V1277280 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_711839 V1277281 I CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) COG4670 Cluster_408931 V1277282 S Inherit from NOG: Leucine rich repeat protein, bspa family protein 0Y4NF Cluster_832590 V1277284 APEA map00480,map01100 E M18 family aminopeptidase COG1362 Cluster_497273 V1277285 UPPP map00550 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) COG1968 Cluster_389514 V1277286 SURB S G5 domain protein 0ZVV3 Cluster_389515 V1277288 P (CBS) domain COG1253 Cluster_489785 V1277289 GLPQ map00564 C glycerophosphoryl diester phosphodiesterase COG0584 Cluster_744972 V1277290 map00052,map00511,map00600,map01100 G hydrolase family 2, sugar binding COG3250 Cluster_748318 V1277291 BMUL_2277 L DNA Methylase COG1475 Cluster_387794 V1277293 M domain protein COG4932 Cluster_427217 V1277297 TTCA D Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) COG0037 Cluster_416232 V1277298 TRAO S conjugative transposon protein TraO 0YB3M Cluster_389516 V1277299 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_394861 V1277304 map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_405491 V1277305 P Na Pi-cotransporter COG1283 Cluster_485135 V1277306 M efflux transporter, rnd family, mfp subunit COG0845 Cluster_744974 V1277307 BMUL_0289 L IS150 protein InsA 180AW@proNOG Cluster_487437 V1277308 P transporter COG0733 Cluster_836415 V1277310 SECE map03060,map03070 U Preprotein translocase SecE subunit 125W8 Cluster_520600 V1277311 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_389517 V1277312 POTD map02010 E ABC transporter COG0687 Cluster_708642 V1277313 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_683555 V1277314 S NA 101UU Cluster_389518 V1277315 FRLC G Not clear, may be involved in an isomerization step COG1082 Cluster_389519 V1277318 D domain protein 0XTIC Cluster_507459 V1277319 GPT map00230,map01100,map01110 F Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) COG0503 Cluster_412596 V1277320 G Alpha-1,2-mannosidase COG3537 Cluster_389520 V1277322 G transporter major facilitator family protein 0ZWFP Cluster_391233 V1277323 T Histidine kinase 0XNMH Cluster_391234 V1277325 GLXK map00260,map00561,map00630,map01100,map01110 G Glycerate kinase COG1929 Cluster_389521 V1277326 HSDR V type iii restriction COG4096 Cluster_777595 V1277327 map02010 P ABC transporter COG1122 Cluster_389522 V1277328 PURF map00230,map00250,map01100,map01110 F glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_389523 V1277329 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_859904 V1277330 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_465259 V1277331 THID map00750,map01100 H Phosphomethylpyrimidine kinase COG0351 Cluster_880304 V1277332 SP_1597 S Membrane COG4720 Cluster_457010 V1277334 RSEP map04112 M Membrane-associated zinc metalloprotease COG0750 Cluster_518027 V1277335 S NA 0ZK9J Cluster_840348 V1277338 map02010 V ABC transporter transmembrane region COG1132 Cluster_699429 V1277339 PUTP E SSS family proline sodium (Na ) symporter COG0591 Cluster_725103 V1277340 S NA 0ZHU9 Cluster_702465 V1277342 I Biotin-requiring enzyme COG0511 Cluster_653312 V1277343 S Oxaloacetate decarboxylase, gamma chain 121NM Cluster_534639 V1277344 CYSK map00270,map00920,map01100,map01120,map01230 E Cysteine synthase COG0031 Cluster_492278 V1277345 S NA 11NI8 Cluster_391235 V1277346 PPK map00190,map03018 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) COG0855 Cluster_515355 V1277347 S Domain of unknown function (DUF1896) 11Y7P Cluster_391236 V1277349 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_443081 V1277350 S copper amine 121X1 Cluster_523338 V1277351 S Membrane COG3610 Cluster_821036 V1277352 S Membrane COG2966 Cluster_408932 V1277354 DAM map03430 L Dna adenine methylase COG0338 Cluster_447131 V1277356 OPPC map02010 P transport system COG1173 Cluster_813423 V1277357 KTRB P Potassium uptake protein COG0168 Cluster_537528 V1277358 KTRA P domain protein COG0569 Cluster_391237 V1277359 T two-component system sensor histidine kinase response regulator, hybrid 0XNMH Cluster_494764 V1277360 PURL F phosphoribosylformylglycinamidine synthase COG0047 Cluster_414457 V1277362 map00860,map01100,map01110 C radical SAM domain protein COG1032 Cluster_427218 V1277364 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E brancheD-chain amino acid aminotransferase COG0115 Cluster_773909 V1277366 S NA 0Z2HQ Cluster_610749 V1277367 PERMEASE S permease COG0701 Cluster_801230 V1277368 CYDC map02010 V ABC transporter, ATP-binding protein COG1132 Cluster_391238 V1277370 P Na Pi-cotransporter COG1283 Cluster_557911 V1277371 S Relaxase mobilization nuclease 0Y9PG Cluster_825008 V1277372 U TraG family COG3505 Cluster_534640 V1277373 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG0194 Cluster_821037 V1277374 RPOZ map00230,map00240,map01100,map03020 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) COG1758 Cluster_391239 V1277375 CSTA T Carbon starvation protein CstA COG1966 Cluster_728430 V1277376 RPOD map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_391240 V1277377 PLDA map00564,map00565,map00590,map00591,map00592,map01100 M phospholipase COG2829 Cluster_603489 V1277379 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_913540 V1277380 DGOT G Major Facilitator 0XR3C Cluster_482825 V1277381 map00520 G n-acylglucosamine 2-epimerase COG2942 Cluster_421625 V1277382 ARSA D Arsenite-activated ATPase (ArsA) COG0003 Cluster_629368 V1277383 DEOB map00030,map00230 G Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) COG1015 Cluster_425275 V1277385 S NA 11KFQ Cluster_393044 V1277387 AMET_1910 S Transposase 0ZT9V Cluster_592916 V1277389 YQIH O chaperone 178BZ@proNOG Cluster_758732 V1277390 YQIH O chaperone 178BZ@proNOG Cluster_447132 V1277392 V ABC transporter, permease COG0577 Cluster_419825 V1277393 CZCD P cation diffusion facilitator family transporter COG0053 Cluster_526251 V1277394 S Acetyltransferase GNAT Family 124QK Cluster_485136 V1277397 SP_0119 L Nudix family COG0494 Cluster_396641 V1277398 MUTS2 L DNA mismatch repair protein COG0249 Cluster_852070 V1277401 L transposase COG3666 Cluster_437067 V1277403 S NA 0YRA4 Cluster_512633 V1277405 YQEY S gatB Yqey COG1610 Cluster_741669 V1277406 DESOR_0674 L Integrase catalytic subunit COG4584 Cluster_618228 V1277407 MAQU_0025 L IstB domain-containing protein ATP-binding protein COG1484 Cluster_393045 V1277408 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_526252 V1277410 K Transcriptional Regulator AraC Family 101VY Cluster_393046 V1277412 FTSW D cell cycle protein COG0772 Cluster_429117 V1277413 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_393047 V1277414 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_848269 V1277415 SP_1232 S Membrane COG4684 Cluster_557912 V1277416 DMPA E, Q peptidase s58 dmpa COG3191 Cluster_453054 V1277417 UGPA map02010 P binding-protein-dependent transport systems inner membrane Component COG1175 Cluster_393048 V1277418 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_805394 V1277419 H IA, variant 3 COG0637 Cluster_610750 V1277420 V Mate efflux family protein COG0534 Cluster_443082 V1277421 S NA 11SJH Cluster_781407 V1277422 D Chromosome partitioning 11HPB Cluster_396642 V1277423 THRC map00260,map00750,map01100,map01120,map01230 E Threonine synthase COG0498 Cluster_394862 V1277424 TRMB C Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_896587 V1277425 S membrane 0Z8C3 Cluster_475888 V1277426 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_614480 V1277427 YHFU S Protein of unknown function DUF2620 17NVC@proNOG Cluster_621871 V1277428 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_570230 V1277429 S NA 0ZHU9 Cluster_394864 V1277433 PURB map00230,map00250,map01100,map01110 F adenylosuccinate lyase COG0015 Cluster_610751 V1277435 LACE map00052,map01100,map02060 G Pts system COG1455 Cluster_394865 V1277436 OATA I Acyl-transferase COG1835 Cluster_394866 V1277437 FOKIM map03430 L Adenine-specific COG3392 Cluster_821038 V1277440 K Bacterial regulatory helix-turn-helix protein, lysR family COG0583 Cluster_396643 V1277441 F ATP cone domain COG1328 Cluster_766499 V1277443 RSBV T stage II sporulation protein COG1366 Cluster_396644 V1277444 CSM3 L CRISPR-associated RAMP protein, Csm3 family COG1337 Cluster_649237 V1277445 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_734947 V1277446 SERA2 map00260,map00680,map01100,map01120,map01230 C Dehydrogenase COG0111 Cluster_461060 V1277447 LKTB3 V ABC transporter, ATP-binding protein COG2274 Cluster_475889 V1277449 S baseplate J family protein COG3299 Cluster_526253 V1277452 RIBD map00740,map01100 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) COG1985 Cluster_394867 V1277453 MIAB J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) COG0621 Cluster_394868 V1277455 HCP C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) COG1151 Cluster_396645 V1277456 U traE protein COG3451 Cluster_403668 V1277458 CTPC map00190 P heavy metal translocating P-type ATPase COG2217 Cluster_770205 V1277459 PHAC map00350,map00362,map00627,map00642,map00650,map00903,map01120 I poly(r)-hydroxyalkanoic acid synthase, class COG3243 Cluster_603490 V1277460 map02010 S ABC-2 type transporter 11H02 Cluster_455067 V1277461 SUFC O feS assembly ATPase SufC COG0396 Cluster_546182 V1277462 S NA 11PZU Cluster_864202 V1277464 map02010 P Abc transporter COG1129 Cluster_518028 V1277465 map02010 S ABC transporter, permease 0ZU5G Cluster_512634 V1277466 YJGJ K Transcriptional regulator 17BVG@proNOG Cluster_396647 V1277467 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_471624 V1277468 PCKA map00010,map00020,map00620,map00710,map01100,map01110,map01120 C Phosphoenolpyruvate Carboxylase COG1866 Cluster_467349 V1277469 ATPC map00190,map00680,map01100 C ATP synthase, subunit 0XPA7 Cluster_396648 V1277470 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_396649 V1277471 S Inherit from COG: leucine Rich Repeat COG4886 Cluster_589512 V1277472 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_692417 V1277473 CYDC map02010 V ABC transporter transmembrane region COG4988 Cluster_702466 V1277474 CYDC map02010 V Abc transporter COG1132 Cluster_497274 V1277475 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_396650 V1277477 GPMA map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0588 Cluster_401880 V1277478 map02010 V ABC transporter COG1132 Cluster_396651 V1277479 S Listeria-Bacteroides repeat domain (List_Bact_rpt) 0YG1D Cluster_396652 V1277480 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_728431 V1277481 ICD map00020,map00480,map00720,map01100,map01110,map01120,map01210,map01230,map04146 C isocitrate dehydrogenase (NADP) COG0538 Cluster_777596 V1277483 FRUA map00051,map01100,map02060 G PTS System COG1445 Cluster_396653 V1277484 RNY S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 Cluster_396654 V1277485 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_398380 V1277486 PROA map00330,map01100,map01230 E Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) COG0014 Cluster_487438 V1277487 FOLP map00790,map01100 H dihydropteroate synthase COG0801 Cluster_412597 V1277488 PITRM1 O peptidase COG1026 Cluster_809425 V1277490 PURM map00230,map01100,map01110 F phosphoribosylaminoimidazole synthetase COG0150 Cluster_537529 V1277491 PURN map00230,map00670,map01100,map01110 F phosphoribosylglycinamide formyltransferase COG0299 Cluster_801231 V1277492 RPLS map03010 J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) COG0335 Cluster_396655 V1277493 S Membrane COG0628 Cluster_621872 V1277496 map02010 V Abc transporter COG1132 Cluster_478093 V1277497 UUP S Abc transporter COG0488 Cluster_398381 V1277499 PROTEASE map05120 O Peptidase U32 COG0826 Cluster_398382 V1277500 S NA 0XR66 Cluster_705567 V1277501 YIAH S Acyl-transferase COG3274 Cluster_534641 V1277503 S Phospholipase D endonuclease domain-containing protein 0Z3N0 Cluster_437069 V1277504 S NA 10WDH Cluster_398383 V1277505 YFIC map02010 V ABC transporter COG1132 Cluster_398385 V1277507 E, G Gluconate COG2610 Cluster_416233 V1277508 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_433092 V1277509 M group 2 family COG0463 Cluster_398386 V1277510 S DNA polymerase iii 101FB Cluster_398387 V1277512 L N-6 DNA Methylase 0Y571 Cluster_398388 V1277513 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_398389 V1277515 NADE map00760,map01100 H nh(3)-dependent nad( ) synthetase COG0171 Cluster_744975 V1277517 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_567143 V1277521 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_400092 V1277522 LACZ map00052,map00511,map00600,map01100 G beta galactosidase small chain COG3250 Cluster_645137 V1277523 T Histidine kinase 0XNMH Cluster_400093 V1277524 NHAC map00680 C Na H antiporter COG1757 Cluster_439084 V1277525 SP_1047 S NA 128UG Cluster_451123 V1277526 YJHU map00561,map00680,map01100,map01120,map04622 K Transcriptional regulator COG2390 Cluster_592917 V1277527 RPLO map03010 J Binds to the 23S rRNA (By similarity) COG0200 Cluster_398390 V1277528 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_398391 V1277529 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_423480 V1277530 DEOA map00240,map00983,map01100,map05219 F The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) COG0213 Cluster_458992 V1277534 VICX map03013 S domain protein COG1235 Cluster_455068 V1277535 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0047 Cluster_398392 V1277536 S NA 0XT1C Cluster_416234 V1277537 TRAD U Conjugative transfer protein COG3505 Cluster_400094 V1277539 map01054 Q synthetase COG1020 Cluster_510055 V1277541 P Natural resistance-associated macrophage protein COG1914 Cluster_423481 V1277542 S NA 0YRUZ Cluster_868159 V1277543 ENC_19000 map00010 G glycoside hydrolase, family 1 COG2723 Cluster_540323 V1277544 ENC_18990 map02060 G PTS system lactose cellobiose family transporter subunit IIC COG1455 Cluster_434999 V1277545 TRKA P potassium transporter peripheral membrane COG0569 Cluster_400095 V1277546 GPMI map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0696 Cluster_900926 V1277547 AGUB map00330,map01100 S Carbon-nitrogen hydrolase COG0388 Cluster_661644 V1277549 ATPD map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG1394 Cluster_825009 V1277550 L DNA alkylation repair enzyme COG4912 Cluster_492279 V1277551 TRPP S tryptophan transport protein 11UPK Cluster_400096 V1277552 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_423482 V1277553 RNY S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 Cluster_400097 V1277554 ARBF map00010,map00500,map00520,map02060 G PTS system beta-glucoside-specific transporter subunit IIABC COG2190 Cluster_400098 V1277555 GLTD C oxidoreductase FAD NAD(P)-binding domain protein COG0543 Cluster_708643 V1277556 USPB S universal stress protein B 17AB3@proNOG Cluster_400099 V1277557 map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_400100 V1277559 S phage plasmid primase, p4 family COG3378 Cluster_614481 V1277560 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_401881 V1277561 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_531852 V1277566 PYRF map00240,map01100 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) COG0284 Cluster_400101 V1277569 S NA 11R2W Cluster_683556 V1277571 LYSC map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Aspartokinase COG0527 Cluster_526254 V1277574 BA_0689 E Transporter COG3104 Cluster_401882 V1277575 TRAG map03070 U TraG TraD family protein COG3505 Cluster_401883 V1277576 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_457011 V1277577 map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) COG1156 Cluster_401884 V1277578 GPSA map00564 C NADPH-dependent glycerol-3-phosphate dehydrogenase COG0240 Cluster_425276 V1277580 IDSA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_529010 V1277581 GLYQS map00970 J Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) COG0423 Cluster_618230 V1277583 map00620,map04011 S Glyoxalase Bleomycin resistance protein (Dioxygenase 0XUYC Cluster_510056 V1277585 TAUA map02010 P ABC transporter substrate-binding protein COG0715 Cluster_401885 V1277586 GLUD map00250,map00330,map00430,map00471,map00910,map01100,map04964 E Glutamate dehydrogenase COG0334 Cluster_400102 V1277587 S NA 17CF4@proNOG Cluster_900927 V1277588 S domain protein 0XNZW Cluster_785495 V1277589 L Transposase COG3547 Cluster_825011 V1277590 RUVC map03440 L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) COG0817 Cluster_453055 V1277592 ETFB map00910 C Electron transfer flavoprotein COG2086 Cluster_552107 V1277593 YHFX E Racemase COG3457 Cluster_401886 V1277595 S degv family COG1307 Cluster_407153 V1277597 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_401888 V1277598 RHAB map00040,map00051 G Rhamnulokinase COG1070 Cluster_403669 V1277599 S membrane 11HPM Cluster_692418 V1277600 V Mate efflux family protein COG0534 Cluster_401889 V1277602 GFCD S (LipO)protein 16RX4@proNOG Cluster_512635 V1277603 map02010 V ABC-2 type transporter COG0842 Cluster_403670 V1277605 S domain protein 0Y14K Cluster_401891 V1277606 TRKH P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) COG0168 Cluster_401892 V1277607 YCGA S c4-dicarboxylate anaerobic carrier COG1288 Cluster_721760 V1277609 S NA 0ZX1V Cluster_699430 V1277610 S secreted protein 0YGV2 Cluster_403671 V1277612 VMRA V Mate efflux family protein COG0534 Cluster_741671 V1277614 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_401893 V1277616 S NA 0Z6CP Cluster_401894 V1277617 D, Z regulator of chromosome condensation, RCC1 COG5184 Cluster_401895 V1277618 RNFC C Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) COG4656 Cluster_773910 V1277619 CYSE map00270,map00920,map01100,map01120,map01230 E serine acetyltransferase COG1045 Cluster_485137 V1277620 COMEC S ComEC rec2-like protein COG0658 Cluster_900928 V1277621 S TIGR02453 family COG5587 Cluster_455070 V1277622 S NA 11IHR Cluster_403672 V1277623 YJJI S glycine radical enzyme YjjI family 0XNMQ Cluster_540324 V1277625 YTQA S Radical SAM Protein COG1242 Cluster_809427 V1277626 K GntR family transcriptional regulator COG2188 Cluster_705568 V1277627 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_645138 V1277628 S tetratricopeptide 0XQVJ Cluster_403673 V1277629 V restriction COG1002 Cluster_414458 V1277630 map02010 P permease protein COG0609 Cluster_469468 V1277632 TRPB map00260,map00400,map01100,map01110,map01230 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) COG0133 Cluster_797257 V1277634 S integral membrane protein 11KHF Cluster_696154 V1277635 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_665855 V1277636 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_734948 V1277638 PBP2B map00550,map01100 M penicillin-binding protein COG0768 Cluster_403674 V1277639 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_431074 V1277640 S NA 0XS0Q Cluster_408934 V1277641 S NA 0YBRU Cluster_403675 V1277642 RPSA map00900,map01100,map01110,map03010 J Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) COG0761 Cluster_403676 V1277643 M Cell wall anchor domain protein 129AF Cluster_537530 V1277645 M peptidase COG0739 Cluster_403677 V1277646 FPRA map00250,map00910,map01100,map01110,map01120,map01230 C reductase COG0493 Cluster_570231 V1277647 map00280,map00362,map00650,map01100,map01120 I glutaconyl-CoA decarboxylase COG4799 Cluster_451124 V1277648 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_414459 V1277649 E extracellular solute-binding protein COG0834 Cluster_423483 V1277650 S ragb susd domaiN-containing protein 0XP53 Cluster_457012 V1277651 LACR K DeoRC COG1349 Cluster_405492 V1277652 S NA 0YCCW Cluster_443083 V1277653 SCLAV_3941 O Band 7 protein COG0330 Cluster_405493 V1277654 L PP-loop domain protein COG1606 Cluster_405494 V1277655 SACA map00052,map00500,map01100 G sucrose-6-phosphate hydrolase COG1621 Cluster_599886 V1277657 YJEI S (LipO)protein 17CPB@proNOG Cluster_475890 V1277658 T response regulator COG2208 Cluster_629370 V1277660 YTFQ map02010,map02030 G Periplasmic binding protein LacI transcriptional regulator 1APIU@spiNOG Cluster_473719 V1277661 APBE H ApbE family COG1477 Cluster_499942 V1277663 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_405495 V1277664 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_405496 V1277665 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_523339 V1277667 S NA 11KMZ Cluster_896589 V1277668 S NA 11ISA Cluster_405497 V1277669 YPSC L Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) COG0116 Cluster_405498 V1277670 S domain protein 0YNW0 Cluster_905216 V1277671 L Phage integrase family 0YUUC Cluster_512636 V1277672 L Phage integrase family 0YUUC Cluster_407154 V1277673 YXCA I coA-substrate-specific enzyme activase COG3581 Cluster_884436 V1277675 VICK T Histidine kinase 0XQQ4 Cluster_443084 V1277679 T Response regulator receiver domain protein COG0745 Cluster_435000 V1277680 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_405500 V1277681 V Type III COG3587 Cluster_405501 V1277682 FTSI map00550 M penicillin-binding protein COG0768 Cluster_458993 V1277683 S Nitroreductase COG3560 Cluster_738276 V1277686 S NA 0ZHU9 Cluster_805395 V1277690 L Addiction module antitoxin, RelB DinJ family 122EC Cluster_687995 V1277695 L site-specific recombinase XerD 0XS3W Cluster_407156 V1277696 GLDM S gliding motility-associated protein gldm 0XREI Cluster_416235 V1277697 G Glycosyl hydrolase family 92 COG3537 Cluster_407157 V1277698 S Capsular polysaccharide biosynthesis protein 0XUBN Cluster_407158 V1277699 DPNA L helicase COG4983 Cluster_407159 V1277700 COAA map00770,map01100 H pantothenic acid kinase COG1072 Cluster_407160 V1277701 YBBK J Purine nucleoside phosphorylase COG1683 Cluster_412598 V1277702 SCLAV_4303 S Abc transporter integral membrane protein 11ZWC Cluster_692419 V1277704 S PQQ COG1520 Cluster_702467 V1277706 map00361,map00625,map01100,map01120 S had-superfamily hydrolase, subfamily ia, variant COG1011 Cluster_731698 V1277707 V ABC transporter COG1132 Cluster_744976 V1277709 K AbrB Family Transcriptional Regulator 12CXU Cluster_407161 V1277710 ENVC D peptidase COG4942 Cluster_407162 V1277711 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_439085 V1277717 HOM map00260,map00270,map00300,map01100,map01110,map01120,map01230 E homoserine dehydrogenase COG0460 Cluster_407163 V1277718 S NA 0YC8I Cluster_407164 V1277719 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_407165 V1277720 S NA 127I3 Cluster_728432 V1277721 SETB G sugar efflux transporter 16SGV@proNOG Cluster_407166 V1277722 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_475891 V1277723 YBIU S Protein of unknown function (DUF1479) 16SAU@proNOG Cluster_407167 V1277724 BPET1060 L DNA polymerase COG3344 Cluster_453056 V1277725 LICR K TRANSCRIPTIONal COG3711 Cluster_408935 V1277726 CINA H cina-like protein COG1058 Cluster_408936 V1277727 YCHM P sulfate transporter COG0659 Cluster_407168 V1277728 THIM map00730,map01100 H 4-methyl-5-beta-hydroxyethylthiazole kinase COG2145 Cluster_567144 V1277729 PURK map00230,map01100,map01110 F phosphoribosylaminoimidazole carboxylase atpase subunit COG0026 Cluster_793293 V1277730 PURE map00230,map01100,map01110 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) COG0041 Cluster_407169 V1277731 S Pfam:DUF88 COG1432 Cluster_408937 V1277732 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_489787 V1277733 S copper amine 121X1 Cluster_576670 V1277736 GCVH map00630,map01110 E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) COG0509 Cluster_408938 V1277738 S ragb susd domaiN-containing protein 0Z2UZ Cluster_408939 V1277739 SURB S G5 domain protein 0ZVV3 Cluster_463174 V1277740 YOJN S ATPase associated with various cellular activities aaa_5 COG0714 Cluster_708644 V1277742 HPYIM map03430 L Adenine-specific COG3392 Cluster_408940 V1277743 ARGS map00970 J arginyl-trna synthetase COG0018 Cluster_583040 V1277745 S NA 0Z6CP Cluster_610754 V1277746 SERC map00260,map00680,map00750,map01100,map01120,map01230 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) COG1932 Cluster_408941 V1277747 SACC map00052,map00500,map01100 G sucrose-6-phosphate hydrolase COG1621 Cluster_407170 V1277748 S Sucrose-6F-phosphate phosphohydrolase 0ZK7W Cluster_423484 V1277749 MEXF V AcrB AcrD family multidrug resistance protein COG0841 Cluster_494765 V1277750 RECR map03440 L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) COG0353 Cluster_407171 V1277751 NADB map00250,map00760,map01100 H L-aspartate oxidase COG0029 Cluster_408942 V1277752 ADE map00230,map01100 F adenine deaminase COG1001 Cluster_414460 V1277753 FTSW map04112 D cell cycle protein, FtsW RodA SpoVE family COG0772 Cluster_407172 V1277754 T Histidine kinase COG2972 Cluster_570232 V1277755 MSRA O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) COG0225 Cluster_408943 V1277756 OPUCD map02010 E Glycine betaine carnitine choline COG1174 Cluster_408944 V1277757 L RNA-directed DNA polymerase COG3344 Cluster_485138 V1277758 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_457013 V1277759 PCKA map00010,map00020,map00620,map00710,map01100,map01110,map01120 C Phosphoenolpyruvate Carboxylase COG1866 Cluster_408945 V1277760 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 Cluster_510057 V1277762 FTSI map00550,map01100 M penicillin-binding protein COG0768 Cluster_408946 V1277763 RNHA map03030 S ribonuclease COG3341 Cluster_408947 V1277764 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_864206 V1277765 CAS2 L CRISPR-associated protein cas2 11VHR Cluster_603491 V1277766 S (LipO)protein 0XSV5 Cluster_653313 V1277767 CUTC P copper homeostasis protein cutc COG3142 Cluster_408948 V1277769 P transport protein COG2985 Cluster_731699 V1277770 S Inherit from COG: Alpha beta hydrolase COG0596 Cluster_408949 V1277771 RPSA map00900,map01100,map01110,map03010 J Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) COG0761 Cluster_418033 V1277774 SCLAV_1692 G major facilitator superfamily COG0477 Cluster_408951 V1277775 P tonB-dependent Receptor COG4771 Cluster_425277 V1277776 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_408952 V1277777 YIHU map00280,map00630,map01100 I NADP oxidoreductase coenzyme F420-dependent COG2084 Cluster_408953 V1277778 ARAD map00040,map00053,map01100,map01120 G L-ribulose-5-phosphate 4-epimerase COG0235 Cluster_755231 V1277779 L Replication Protein 0YRQ2 Cluster_408954 V1277780 S Radical SAM superfamily COG0641 Cluster_546183 V1277781 P tonB-dependent Receptor 0XP5Y Cluster_492280 V1277784 TRMB C Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_425278 V1277785 ARGS map00970 J arginyL-tRNA synthetase COG0018 Cluster_408955 V1277786 ZNUB1 map02010 P Transporter COG0609 Cluster_410773 V1277787 S copper amine oxidase-like domain-containing protein 120H1 Cluster_485139 V1277788 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_410774 V1277789 S NA 11HA5 Cluster_705570 V1277790 S NA 11NK7 Cluster_661645 V1277791 S Abortive infection protein AbiGII 0XQHH Cluster_445072 V1277792 C nitrogenase 0XTW4 Cluster_408956 V1277793 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_408957 V1277795 CAUL_0340 L Transposase COG2801 Cluster_410775 V1277796 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_702468 V1277797 MARC U multiple antibiotic resistance (MarC)-related protein COG2095 Cluster_699433 V1277798 UPPP map00550 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) COG1968 Cluster_482826 V1277799 S PAP2 superfamily domain protein 126EI Cluster_525438 V1027602 RECQ2 map03018 L ATP-dependent DNA helicase COG0514 Cluster_757762 V1027603 HPAD map00350,map01120 Q 3,4-dihydroxyphenylacetate 2,3-dioxygenase COG3384 Cluster_819752 V1027604 HPCD map00350,map01120 Q 5-carboxymethyl-2-hydroxymuconate COG3232 Cluster_796144 V1027607 S NA 11YBG Cluster_867089 V1027608 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_808258 V1027611 MERR2 K merR family transcriptional Regulator COG0789 Cluster_812268 V1027612 RZPD M Rz endopeptidase from lambdoid prophage DLP12 17HB7@proNOG Cluster_588503 V1027614 BA_5405 S Membrane COG2855 Cluster_522559 V1027615 PHNI map00440 P Phosphonate metabolism protein COG3626 Cluster_525440 V1027620 S NA 0XNQB Cluster_522560 V1027621 BMUL_4510 T CheA signal transduction histidine kinase 173Z7@proNOG Cluster_733960 V1027622 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_707795 V1027623 RPLE map03010 J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COG0094 Cluster_895441 V1027624 RPSN map03010 J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) COG0199 Cluster_525441 V1027625 S NA 0ZHU9 Cluster_522561 V1027626 LHR L dEAD DEAH box helicase COG1201 Cluster_765347 V1027627 GREA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) COG0782 Cluster_522562 V1027629 NAGB map00520,map01100,map01110 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COG0363 Cluster_572467 V1027630 RPOD map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_525442 V1027631 GCL map00630,map01100 S glyoxylate carboligase COG3960 Cluster_780147 V1027633 S NA 17D58@proNOG Cluster_730764 V1027636 ZITB P cation diffusion facilitator family transporter COG1230 Cluster_533780 V1027638 SCLAV_4061 S Uncharacterised conserved protein (DUF2342) COG5282 Cluster_525444 V1027643 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_754198 V1027645 map00100,map01100,map01110 I Fatty Acid Hydroxylase COG3000 Cluster_525445 V1027646 S conserved domain protein 11RSW Cluster_733961 V1027652 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_839059 V1027654 RAMB K transcriptional regulator COG3800 Cluster_730765 V1027655 SEPF S Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) COG1799 Cluster_525447 V1027657 S NA 0YRUB Cluster_595288 V1027658 TUF map04626 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 Cluster_554138 V1027660 PILN U (type IV) pilus 178Z2@proNOG Cluster_598867 V1027664 CLC P Chloride channel COG0038 Cluster_780149 V1027665 FLIC map02020,map02040,map04626,map05132,map05134 N Flagellin COG1344 Cluster_804294 V1027668 TPDA E peptidase COG0624 Cluster_528256 V1027670 DAPD map00300,map01100,map01120,map01230 E Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) COG2171 Cluster_542278 V1027676 IMPJ U type VI secretion protein, VC_A0114 family COG3522 Cluster_652032 V1027682 BMUL_1120 H Molybdopterin binding domain protein COG1058 Cluster_566175 V1027687 YJIP S Transposase COG5464 Cluster_620768 V1027690 YHCC S Radical SAM Protein COG1242 Cluster_525449 V1027691 S Pfam:DUF1468 1819C@proNOG Cluster_528258 V1027694 map02010 G NA 10Q7N Cluster_528259 V1027695 S NA 11QZ9 Cluster_533781 V1027696 DNAQ2 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit epsilon COG0847 Cluster_701640 V1027697 OPRC P receptor COG1629 Cluster_528260 V1027700 NARI map00910,map01120,map02020 C nitrate reductase, gamma subunit COG2181 Cluster_525450 V1027701 G TRAP dicarboxylate transporter, DctP subunit COG1638 Cluster_528261 V1027702 S (LipO)protein 0XQ9B Cluster_528262 V1027705 LHR L helicase COG1201 Cluster_750756 V1027707 S NA 181BB@proNOG Cluster_528263 V1027709 AROE map00400,map01100,map01110,map01230 E shikimate dehydrogenase COG0169 Cluster_724183 V1027710 YAZA L domain protein COG2827 Cluster_528264 V1027713 CORA P magnesium and cobalt transport protein CorA COG0598 Cluster_591874 V1027714 MENF map00130,map01053,map01100,map01110 H Isochorismate synthase COG1169 Cluster_528265 V1027715 M Sortase family COG3764 Cluster_528266 V1027720 S NA 17YCP@proNOG Cluster_816086 V1027726 P Rhodanese-like domain 121TY Cluster_757763 V1027730 L Phage integrase family protein 177B6@proNOG Cluster_776571 V1027731 BL01373 L Integrase COG0582 Cluster_528268 V1027733 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_528269 V1027735 MRAY map00550,map01100 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) COG0472 Cluster_730767 V1027736 YRZL S UPF0297 protein COG4472 Cluster_531006 V1027737 PKNL T Serine Threonine protein kinase COG2815 Cluster_528270 V1027738 ALDA map00620,map00630,map01120 C Dehydrogenase COG1012 Cluster_628214 V1027739 S phage portal protein, SPP1 0ZZDC Cluster_531007 V1027745 ACRB3 P acriflavin resistance protein COG0841 Cluster_578787 V1027749 BMUL_1119 S Putative transmembrane protein 174GG@proNOG Cluster_750758 V1027752 S Protein of unknown function (DUF3039) 11WTE Cluster_528271 V1027753 HSDR V type I restriction-modification system COG0610 Cluster_528272 V1027754 YCFI map02010 V abc transporter COG1132 Cluster_624519 V1027756 BMUL_5604 S NA 17K4B@proNOG Cluster_531009 V1027758 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_531010 V1027763 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_701641 V1027765 RPPH map03018 J Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) COG0494 Cluster_531011 V1027766 P Nadph-dependent fmn reductase COG0431 Cluster_695175 V1027768 S NA 129QP Cluster_595289 V1027769 RPLN map03010 J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) COG0093 Cluster_899632 V1027770 S hydrolase COG0561 Cluster_588504 V1027772 CSM map00400,map01100,map01110,map01230 E chorismate mutase COG1605 Cluster_531012 V1027774 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_656199 V1027780 BMUL_1001 S Spovr like family protein COG3803 Cluster_531014 V1027781 SMC D Required for chromosome condensation and partitioning (By similarity) COG1196 Cluster_531016 V1027788 MALQ map00500,map01100 G 4-alpha-glucanotransferase (EC 2.4.1.25) COG1640 Cluster_533782 V1027790 S Phage infection protein COG1511 Cluster_533783 V1027791 GLT map00630,map00910 E glutamate synthase COG0069 Cluster_916726 V1027793 BMUL_1739 U Polypeptide-transport-associated domain protein ShlB-type COG2831 Cluster_934405 V1027798 S Pfam:TnsA_N 179Y7@proNOG Cluster_628215 V1027799 L Transposition protein 16VFT@proNOG Cluster_805396 V1277801 SP_0742 S degv family COG1307 Cluster_529011 V1277803 P TonB-linked outer membrane protein, SusC RagA family 0YJXD Cluster_410776 V1277804 P TonB-dependent Receptor Plug 0XRHT Cluster_797258 V1277805 S NA 1265D Cluster_410778 V1277807 FUMB map00020,map00630,map00720,map01100,map01110,map01120 C fumarate COG1951 Cluster_410780 V1277809 RBR C Rubrerythrin COG1853 Cluster_499944 V1277810 GDH map00250,map00330,map00910,map01100 E Glutamate dehydrogenase COG0334 Cluster_431075 V1277811 GLTD map00450 E Selenate reductase, YgfK COG0493 Cluster_797259 V1277812 YQFA S hemolysin iii COG1272 Cluster_610755 V1277813 S domain protein COG1917 Cluster_546184 V1277817 METI map02010 P ABC transporter, permease COG2011 Cluster_592918 V1277820 CYDC map02010 V ABC transporter, ATP-binding protein COG1132 Cluster_762547 V1277821 NIST map02010 V ABC transporter 0XPIZ Cluster_410781 V1277822 FUSA2 J Translation elongation factor COG0480 Cluster_708645 V1277824 C FMN-binding domain protein COG3976 Cluster_785496 V1277825 CCPA K Transcriptional regulator COG1609 Cluster_427220 V1277826 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_423485 V1277827 NIFU C May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins COG0822 Cluster_412599 V1277828 STP T phosphatase COG0631 Cluster_451125 V1277829 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_458994 V1277830 C symporter COG1301 Cluster_412600 V1277832 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_744977 V1277833 S NA 0XU7T Cluster_751763 V1277834 S NA 125GS Cluster_410782 V1277836 M Cell wall anchor domain protein 11Q8J Cluster_412601 V1277837 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_708646 V1277838 RPSI map03010 J 30S ribosomal protein S9 COG0103 Cluster_412602 V1277839 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0149 Cluster_410783 V1277840 YXCA I coA-substrate-specific enzyme activase COG3581 Cluster_412603 V1277841 P TonB dependent receptor 0XNNV Cluster_410784 V1277844 PURB map00230,map00250,map01100,map01110 F adenylosuccinate lyase COG0015 Cluster_410785 V1277845 PITA P phosphate transporter COG0306 Cluster_809428 V1277846 SPSC map00362,map00363,map00520,map00626,map00650,map00903,map01100,map01110,map01120,map02020 M Polysaccharide biosynthesis protein COG0399 Cluster_607104 V1277847 WCFS map00051 M transferase COG2148 Cluster_637253 V1277848 CPN_0573 K transcriptional regulatory protein COG0217 Cluster_836416 V1277849 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_412604 V1277850 B, K radical SAM domain protein COG1243 Cluster_412605 V1277851 CDR map00190 P pyridine nucleotide-disulfide oxidoreductase COG0607 Cluster_416236 V1277852 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_507460 V1277853 L Inherit from NOG: transposase 11VUP Cluster_469469 V1277854 RBSC-1 S (ABC) transporter COG4603 Cluster_453057 V1277855 L integrase family 0XRS7 Cluster_725107 V1277859 PPX map00230 F, P ppx gppa phosphatase COG0248 Cluster_412606 V1277861 PITRM1 O peptidase COG1026 Cluster_412607 V1277862 BL00983 S Phage Portal Protein 11QNG Cluster_494766 V1277863 S NA 0Y00S Cluster_414461 V1277865 map00052,map00500,map01100 G sucrose-6-phosphate hydrolase COG1621 Cluster_573463 V1277866 SCLAV_3420 map02010,map02020 V abc transporter COG1131 Cluster_414462 V1277869 SPOVK O AAA ATPase, central domain protein COG0464 Cluster_412608 V1277870 YCHF J gtp-binding protein COG0012 Cluster_453058 V1277872 OMT map00340,map00350,map00624,map01120 S O-Methyltransferase 0XTC6 Cluster_461061 V1277873 RNFE C Electron transport complex COG4660 Cluster_467350 V1277876 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_492281 V1277877 S RteC protein 10SVC Cluster_414463 V1277878 GLGA map00500,map01100,map01110,map04973 G Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) COG0297 Cluster_844386 V1277881 TRER K GntR family transcriptional regulator COG2188 Cluster_412609 V1277883 I alpha/beta hydrolase fold COG0657 Cluster_813426 V1277885 NASD map00910,map01120 C nitrite reductase, (NAD(P)H) COG1251 Cluster_589513 V1277886 NASD map00910,map01120 C nitrite reductase, (NAD(P)H) COG1251 Cluster_599887 V1277888 DMSB C Iron-sulfur COG0437 Cluster_674557 V1277890 CTPA M Carboxyl-terminal protease COG0793 Cluster_805397 V1277891 YHEV S nucleicacid-binding protein COG3529 Cluster_653317 V1277892 COBB map00860,map01100 H Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) COG1797 Cluster_512637 V1277894 YAAO map00310,map00330,map00960,map01100,map01110 E decarboxylase COG1982 Cluster_414465 V1277895 PCT map00620,map00640,map00643,map01100,map01120 I CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) COG4670 Cluster_766501 V1277896 LGAS_0621 S Phage cell wall hydrolase 0XSRY Cluster_414466 V1277898 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_781411 V1277899 S NA 0Y3I0 Cluster_909290 V1277900 THRH map00260,map00680,map01100,map01120,map01230 E phosphoserine phosphatase homoserine phosphotransferase bifunctional protein COG0560 Cluster_412610 V1277901 S NA 11IN7 Cluster_412611 V1277902 F Permease family COG2233 Cluster_718456 V1277903 XYLH map02010 G ABC transporter COG4214 Cluster_414468 V1277905 PLDA map00564,map00565,map00590,map00591,map00592,map01100 M phospholipase COG2829 Cluster_445073 V1277906 CTPC map00190 P heavy metal translocating P-type ATPase COG2217 Cluster_414469 V1277908 RECX map00561,map01100 M Glycosyl transferase (Group 1 COG0438 Cluster_414470 V1277909 SUFB O FeS assembly protein SUFB COG0719 Cluster_445074 V1277910 AMIA map02010 E Oligopeptide-binding protein COG4166 Cluster_414471 V1277911 S tape measure domain protein 11PSY Cluster_414473 V1277913 C Hydrogenase large subunit domain protein COG4624 Cluster_621874 V1277915 S conjugation system ATPase, TraG family 0XSHU Cluster_478094 V1277916 S Membrane 11ZHS Cluster_416237 V1277917 MELS_0665 L reverse transcriptase COG3344 Cluster_414474 V1277918 PEPS E aminopeptidase COG2309 Cluster_567145 V1277919 YBAQ K plasmid maintenance system antidote protein, xre family COG3093 Cluster_563942 V1277920 K Transcriptional Regulator AraC Family 1AP74@spiNOG Cluster_416238 V1277921 BGLH G Outer membrane porin COG4580 Cluster_478095 V1277922 S NA 0YQGS Cluster_512638 V1277923 LEXA K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) COG1974 Cluster_414475 V1277925 L integrase family 0XRS7 Cluster_414476 V1277927 METY map00270,map00450,map00920,map01100,map01110,map01230 E O-acetylhomoserine COG2873 Cluster_884437 V1277928 FOLE map00790,map01100 H GTP cyclohydrolase i COG0302 Cluster_586227 V1277929 PURE map00230,map01100,map01110 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) COG0041 Cluster_418034 V1277931 GLGB map00500,map01100,map01110 G 1,4-alpha-glucan branching enzyme COG0296 Cluster_570233 V1277932 S NA 0Z81M Cluster_414477 V1277934 FBP map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120 G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 COG3855 Cluster_610757 V1277935 map02010 P Binding-protein-dependent transport system inner membrane component COG0395 Cluster_900930 V1277936 SCLAV_4834 map02010 P binding-protein-dependent transport systems inner membrane Component COG1175 Cluster_414478 V1277938 M Bacteriophage peptidoglycan hydrolase COG0791 Cluster_416240 V1277939 PRC M Peptidase, S41 family COG0793 Cluster_414479 V1277941 YQFA S UPF0365 protein COG4864 Cluster_416243 V1277943 FPRA C domain protein COG0426 Cluster_416244 V1277944 NAGA map00052,map00520,map01110 G GlcNAc 6-P deacetylase COG1820 Cluster_416245 V1277945 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_414480 V1277947 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_416247 V1277949 DPAL map00260,map00290,map01100,map01110,map01230 E Diaminopropionate ammonia-lyase COG1171 Cluster_475892 V1277950 SNF map00230 L Helicase COG0553 Cluster_416248 V1277951 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_416249 V1277954 C FMN-binding domain protein COG3976 Cluster_515357 V1277955 K Transcriptional regulator COG1414 Cluster_416250 V1277956 S NA 0YXS4 Cluster_416251 V1277958 S NA 11QNK Cluster_518029 V1277960 S NA 11XN8 Cluster_523340 V1277961 map00130,map00770,map01100,map01110 S Methyltransferase 0ZVQZ Cluster_480483 V1277964 SRTB M (sortase) family COG3764 Cluster_416252 V1277965 S tetratricopeptide repeat 0YK8K Cluster_416253 V1277967 OCAR_7462 map00270,map00450,map01100,map01110,map01230 E Methionine synthase COG0620 Cluster_463175 V1277968 E Glycosyl Hydrolase Family 88 COG4225 Cluster_494767 V1277969 map00623,map01100,map01120 C FAD linked oxidase domain protein COG0277 Cluster_418035 V1277970 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120 G phosphohexose isomerase COG0166 Cluster_687996 V1277971 LIN1243 S domain protein COG1235 Cluster_416254 V1277972 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_599888 V1277973 DCMB map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_738278 V1277974 NAGB map00520,map01100,map01110 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COG0363 Cluster_418036 V1277975 SURB S G5 domain protein 0ZVV3 Cluster_418037 V1277977 HILA K Invasion protein COG3710 Cluster_797260 V1277979 SCLAV_0594 K LysR family transcriptional regulator COG0583 Cluster_416255 V1277980 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_439086 V1277981 map02010 V abc transporter COG1132 Cluster_766502 V1277982 SODB map04146,map05016 P Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) COG0605 Cluster_751764 V1277983 SDAAB map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase, iron-sulfur-dependent, beta subunit COG1760 Cluster_502476 V1277985 map00230,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_416256 V1277986 MALX map00010,map00500,map00520,map02060 G PTS System COG1263 Cluster_485140 V1277987 NADD map00230,map00760,map01100,map05340 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) COG1057 Cluster_418038 V1277988 S tetratricopeptide 11P8K Cluster_416257 V1277989 KTRB P Potassium uptake protein COG0168 Cluster_557913 V1277990 S NA 0Y5MX Cluster_618231 V1277991 SIGX K RNA Polymerase COG1595 Cluster_543253 V1277993 S NA 0Z6JP Cluster_599889 V1277994 S NA 1224P Cluster_777597 V1277995 SIGB K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG1191 Cluster_599890 V1277996 PRMA J Methylates ribosomal protein L11 (By similarity) COG2264 Cluster_485141 V1277999 DNAC L DNA replication protein COG1484 Cluster_419826 V1278001 PLSC map00561,map00564,map01100 I Acyl-transferase COG0204 Cluster_507461 V1278002 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_741673 V1278003 S NA 11Q97 Cluster_678990 V1278004 S NA 0YBKF Cluster_469470 V1278005 ISPD map00900,map01100,map01110 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COG1211 Cluster_423486 V1278006 F Permease family COG2233 Cluster_418039 V1278007 H Transporter COG2978 Cluster_805399 V1278008 G Glycosidase related protein COG2152 Cluster_603492 V1278009 MANA map00051 G Mannan endo-1,4-beta-mannosidase COG4124 Cluster_418040 V1278010 M NA 0ZYVM Cluster_457014 V1278012 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_435001 V1278013 SSNA F selenium metabolism protein SsnA COG0402 Cluster_560965 V1278014 PSPG S Phage shock protein G 17JI6@proNOG Cluster_419827 V1278015 GLCD map00620,map00630,map01100,map01110,map01120 C FAD linked oxidase domain-containing protein COG0277 Cluster_419828 V1278016 S NA 0XR9X Cluster_758735 V1278017 GLPB map00564 E anaerobic glycerol-3-phosphate dehydrogenase, subunit B COG3075 Cluster_507462 V1278018 YGBM map00040,map00630,map01100 G Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) COG3622 Cluster_423487 V1278019 S Filamentation induced by cAMP protein fic COG3177 Cluster_419829 V1278020 ISDF map02010 P ABC transporter, permease COG0609 Cluster_418041 V1278021 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_502477 V1278022 ACA4 P Calcium-translocating P-type ATPase, PMCA-type COG0474 Cluster_419830 V1278026 V Inherit from bactNOG: (ABC) transporter COG1132 Cluster_554998 V1278027 S mobilization protein 11J0G Cluster_785498 V1278028 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_596389 V1278029 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_467351 V1278030 S Protein of unknown function (DUF2807) 0Y65M Cluster_586228 V1278033 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_770206 V1278036 SP_1935 S Domain of unknown function (DUF955) 11KQS Cluster_603493 V1278037 SP_1934 S NA 11SH4 Cluster_419831 V1278038 S UPF0272 protein COG1641 Cluster_419832 V1278039 YBGK map00330,map00791,map01100,map01120 E Allophanate hydrolase subunit 2 COG1984 Cluster_418042 V1278040 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_418043 V1278041 SP_2057 I Acyl-transferase COG1835 Cluster_549217 V1278042 SP_0239 S UPF0210 protein COG2848 Cluster_453059 V1278043 KTRA P domain protein COG0569 Cluster_478098 V1278044 FOPA M ompA family 10ZT3 Cluster_725108 V1278045 PTSH G phosphocarrier protein (HPr COG1925 Cluster_419833 V1278047 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_489788 V1278049 RFAZ M lipopolysaccharide core biosynthesis protein 16SEV@proNOG Cluster_852071 V1278051 S Phage portal protein, SPP1 Gp6-like 11J8D Cluster_419834 V1278052 V Type I restriction modification DNA specificity domain COG0732 Cluster_419835 V1278053 SETA G sugar efflux transporter 16SGV@proNOG Cluster_433093 V1278054 TRAA map03440 L mobA MobL family protein COG0507 Cluster_762548 V1278055 RPLO map03010 J Binds to the 23S rRNA (By similarity) COG0200 Cluster_614482 V1278056 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_419836 V1278057 BGLC3 map00460,map00500,map00940,map01100,map01110 G ec 3.2.1.21 COG2723 Cluster_419837 V1278058 SUFB O FeS assembly protein SUFB COG0719 Cluster_755233 V1278059 OCAR_6158 L Terminase, large subunit COG4626 Cluster_419838 V1278062 T Histidine kinase COG0642 Cluster_445075 V1278063 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_419839 V1278064 SP_2027 S MORN repeat protein COG4642 Cluster_748322 V1278066 S NA 0Z5X7 Cluster_419842 V1278069 VANW V VanW family COG2720 Cluster_419843 V1278070 S DNA-binding protein COG3943 Cluster_419844 V1278071 V Type II restriction m6 adenine DNA methyltransferase, Alw26I Eco31I Esp3I family 125HB Cluster_419845 V1278074 GYRA2 L DNA topoisomerase IV subunit A COG0188 Cluster_683558 V1278075 S NA 0YFKX Cluster_702469 V1278076 AMAA map00360 E Peptidase dimerisation domain COG1473 Cluster_576671 V1278077 YABR J RNA binding s1 domain protein COG1098 Cluster_507463 V1278078 L Inherit from NOG: transposase 11VUP Cluster_421626 V1278081 CAS3 L CRISPR-associated helicase, cas3 COG1203 Cluster_741674 V1278082 S NA 0YP0J Cluster_674558 V1278083 S sigma-70 region 2 1288G Cluster_421627 V1278084 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_421628 V1278085 HTPG map04141,map04151,map04612,map04621,map04626,map04914,map04915,map05200,map05215 O Molecular chaperone. Has ATPase activity (By similarity) COG0326 Cluster_583042 V1278086 PHEA map00400,map00401,map01100,map01110,map01230 E Prephenate dehydratase COG0077 Cluster_421629 V1278087 S NA 0YYC5 Cluster_610758 V1278090 YJIM E 2-hydroxyglutaryl-CoA dehydratase COG1775 Cluster_421630 V1278091 map02010 G ABC transporter COG1129 Cluster_625672 V1278092 ALR map00300,map00473,map00550,map01100 M Alanine racemase COG0787 Cluster_437071 V1278094 TRKH P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) COG0168 Cluster_421632 V1278096 MURP map00010,map00500,map00520,map02060 G The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is COG2190 Cluster_421633 V1278097 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_421634 V1278098 S Phage tail tape measure protein, TP901 family 10QPB Cluster_773911 V1278099 DTD J Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) COG1490 Cluster_421635 V1278101 MANY map00051,map00520,map01100,map02060 G PTS System COG3715 Cluster_421636 V1278102 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit delta' COG1466 Cluster_537532 V1278103 S NA 0XT3G Cluster_421637 V1278104 S cell wall binding COG5263 Cluster_421638 V1278105 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_421639 V1278106 V ABC transporter COG1132 Cluster_557914 V1278108 YITL S S1 RNA binding domain protein COG2996 Cluster_421640 V1278109 S ATP GTP-binding protein 0Y0B5 Cluster_455072 V1278111 AGCS E amino acid carrier protein COG1115 Cluster_751765 V1278112 RBSR K Transcriptional regulator COG1609 Cluster_423488 V1278114 PHUW E Iron-regulated protein COG3016 Cluster_423489 V1278115 PHOR map02020 T Histidine kinase 0XNMH Cluster_529012 V1278116 T regulator, lux-R family COG2197 Cluster_451126 V1278117 RSMG M Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) COG0357 Cluster_449144 V1278118 AMYE map02010 G solute-binding protein COG1653 Cluster_487439 V1278119 L Transposase 11X46 Cluster_510061 V1278120 S domain protein 12C1H Cluster_421641 V1278121 SURB S G5 domain protein 0ZVV3 Cluster_421642 V1278122 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_563943 V1278123 ANSA map00250,map00460,map00910,map01100,map01110 E L-asparaginase COG0252 Cluster_610759 V1278124 FUR P Ferric uptake COG0735 Cluster_762549 V1278125 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_583043 V1278126 SAMA_0596 L Transposase COG1943 Cluster_457015 V1278127 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_427221 V1278128 OCAR_4033 S NA 0XQD4 Cluster_586229 V1278129 PHAJ I MaoC domain protein dehydratase COG2030 Cluster_423490 V1278131 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_439087 V1278132 V abc transporter permease protein COG0577 Cluster_421643 V1278133 Q PKS_KR COG3321 Cluster_423491 V1278135 METQ map02010 P Lipoprotein COG1464 Cluster_586230 V1278136 COMEC S Competence protein COG2333 Cluster_859908 V1278137 HTH_0473 L Transposase COG0675 Cluster_423492 V1278139 S NA 0ZTYV Cluster_443085 V1278143 S ABC transporter, ATP-binding protein COG0488 Cluster_421644 V1278144 S NA 0ZHVH Cluster_751767 V1278146 RPLM map03010 J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) COG0102 Cluster_423493 V1278147 S NA 0XW02 Cluster_625673 V1278148 L NA 0YKV1 Cluster_423494 V1278149 CSTA T Carbon starvation protein CstA COG1966 Cluster_497275 V1278150 S DNA-binding helix-turn-helix protein 11HJM Cluster_625674 V1278154 YHEO E YheO domain protein COG2964 Cluster_423496 V1278156 GCDH map00071,map00310,map00380,map01100 I Dehydrogenase COG1960 Cluster_497276 V1278157 S OsmC-like protein 124NV Cluster_423497 V1278158 DPIA map02020 T transcriptional regulatory protein COG4565 Cluster_423498 V1278159 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_461062 V1278160 S Membrane 122M6 Cluster_549218 V1278162 S YycH protein 0ZZRJ Cluster_433094 V1278163 GND map00030,map00480,map01100,map01110,map01120 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) COG0362 Cluster_494768 V1278164 TRAA map03440 L mobA MobL family protein COG0507 Cluster_425280 V1278165 S NA 0YZ82 Cluster_423500 V1278166 RLUD J pseudouridine synthase COG0564 Cluster_423501 V1278167 S radical SAM domain protein COG0641 Cluster_423502 V1278168 S X-X-X-Leu-X-X-Gly heptad repeats COG1511 Cluster_485142 V1278171 CORA P transporter COG0598 Cluster_603494 V1278172 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_805401 V1278173 HFQ map03018 T RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) COG1923 Cluster_465261 V1278174 SCLAV_2951 T Fha domain containing protein COG1716 Cluster_425281 V1278179 S s-layer domain-containing protein 0YAE9 Cluster_504890 V1278181 SPAR T response regulator COG0745 Cluster_657439 V1278182 XDHC map00230,map00633,map00680,map00720,map01100,map01120 F (2Fe-2S)-binding domain protein COG2080 Cluster_423503 V1278183 SP_0341 S UPF0371 protein COG4868 Cluster_637254 V1278186 L site-specific recombinase, phage integrase family 11IW4 Cluster_423504 V1278188 G glycosyl hydrolase COG1501 Cluster_425283 V1278189 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_596390 V1278193 S Abortive infection protein AbiGII 0XQHH Cluster_423505 V1278195 E POLIIIAc COG1387 Cluster_641253 V1278196 FBAB map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01230 G fructose-bisphosphate aldolase COG1830 Cluster_836419 V1278197 GPMA map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0588 Cluster_560966 V1278198 MDTL V Multidrug resistance protein MdtL 174MZ@proNOG Cluster_510063 V1278199 K ArsR family transcriptional regulator 0XUQV Cluster_425284 V1278201 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_766503 V1278202 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_423506 V1278203 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_425285 V1278204 S NA 101UU Cluster_429119 V1278205 map02010 S Permease, YjgP YjgQ family COG0795 Cluster_425286 V1278206 S xylan esterase 0XQP6 Cluster_423507 V1278207 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_425287 V1278208 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_423508 V1278209 S NA 102QB Cluster_718458 V1278210 CORA P magnesium and cobalt transport protein CorA COG0598 Cluster_762550 V1278211 HLYX P CBS domain protein COG1253 Cluster_567146 V1278212 YXBA S ATP-grasp COG3919 Cluster_441078 V1278213 YHBB2 S NA 11IEN Cluster_425288 V1278214 V Efflux ABC transporter, permease protein 0XPE8 Cluster_425290 V1278216 NNRD G Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) COG0063 Cluster_425291 V1278217 map00230,map00240,map03018 J polyribonucleotide nucleotidyltransferase COG1185 Cluster_425292 V1278218 YAET M outer membrane protein assembly complex, YaeT protein COG4775 Cluster_425293 V1278220 P Transporter COG0733 Cluster_461063 V1278222 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_526255 V1278223 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_447133 V1278224 S NA 0YDFB Cluster_531854 V1278225 S general stress protein 0XVE3 Cluster_596391 V1278226 M Pilin isopeptide linkage domain protein 11AV1 Cluster_425294 V1278227 V Efflux ABC transporter, permease protein 0XPE8 Cluster_492282 V1278229 PUUD J Glutamine amidotransferase COG2071 Cluster_425296 V1278231 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_461064 V1278232 L Transposase COG3436 Cluster_520601 V1278233 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_427222 V1278235 map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_637255 V1278237 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_770207 V1278240 S Hydrid cluster protein-associated redox disulfide domain protein 123UM Cluster_653318 V1278243 PYRI map00240,map00250,map01100 F Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) COG1781 Cluster_425297 V1278244 FRUA map00051,map01100,map02060 G PTS System COG1762 Cluster_467352 V1278245 AGLA map00052,map00500,map01100 G alpha amylase, catalytic region COG0366 Cluster_427223 V1278247 map02010 G ABC transporter COG1129 Cluster_427224 V1278251 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_485143 V1278255 NUSG K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 Cluster_453060 V1278256 map03440 K Divergent AAA domain protein COG2865 Cluster_427225 V1278257 CZCD P cation diffusion facilitator family transporter COG0053 Cluster_665857 V1278262 E peptidase COG2195 Cluster_665858 V1278263 YDDQ E, P ABC transporter permease protein COG1173 Cluster_596392 V1278266 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_603495 V1278267 S glycoside hydrolase family protein 0XQCX Cluster_429120 V1278269 S TraX protein 11N9P Cluster_485144 V1278272 GPMB map00010,map00260,map00680,map01100,map01110,map01120,map01230 G phosphoglycerate mutase COG0406 Cluster_427226 V1278273 S KAP P-loop COG4928 Cluster_629372 V1278274 FTHC map00670,map01100 H 5-formyltetrahydrofolate cyclo-ligase COG0212 Cluster_504891 V1278279 map02020 T Histidine kinase COG0642 Cluster_433095 V1278280 S NA 12BEU Cluster_427227 V1278281 VPA1266 map03440 L Helicase, RecD TraA family COG4932 Cluster_427228 V1278283 TETP T Tetracycline resistance protein COG0480 Cluster_546185 V1278284 S NA 0XYQ4 Cluster_429121 V1278285 ASD map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) COG0136 Cluster_494769 V1278286 O Bacterial trigger factor protein (TF) COG0544 Cluster_427229 V1278287 SURB S G5 domain protein 0ZVV3 Cluster_523341 V1278288 YCCU S CoA-binding domain protein COG1832 Cluster_427230 V1278289 M mechanosensitive ion channel COG0668 Cluster_427231 V1278290 P transporter COG0733 Cluster_429122 V1278291 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_427232 V1278292 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_429123 V1278294 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_429124 V1278295 GSPE map03070 U type ii secretion system protein e COG2804 Cluster_478099 V1278296 UVRD map03420,map03430 L Helicase COG0210 Cluster_451127 V1278297 ALKA map03410 L 8-oxoguanine DNA glycosylase COG0122 Cluster_429125 V1278298 DCUB map02020 O Anaerobic c4-dicarboxylate transporter COG2704 Cluster_429126 V1278299 CAS3 L CRISPR-Associated Helicase Cas3 COG1203 Cluster_770209 V1278301 S NA 0ZHU9 Cluster_429128 V1278302 P tonB-dependent Receptor 0XQJQ Cluster_429129 V1278303 LIN1243 S domain protein COG1235 Cluster_429130 V1278304 L DNA helicase COG1112 Cluster_429131 V1278308 BAES map02020 T Histidine kinase COG0642 Cluster_429132 V1278309 CCMA V ABC transporter COG1131 Cluster_529013 V1278313 YHHW S pirin domain protein COG1741 Cluster_469471 V1278314 P TonB dependent receptor 0XNNV Cluster_475893 V1278315 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_529014 V1278316 V Inherit from COG: Type II restriction enzyme, methylase COG1002 Cluster_429133 V1278317 DMPA E, Q peptidase s58 dmpa COG3191 Cluster_557915 V1278318 RPH map00230,map00240,map01100 J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) COG0689 Cluster_429134 V1278319 SSNA F selenium metabolism protein SsnA COG0402 Cluster_429135 V1278322 G Inherit from NOG: Bacterial Ig-like domain (group 3) 0ZMQN Cluster_840353 V1278324 R15 L integrase catalytic COG2801 Cluster_461065 V1278325 YWJA V ABC transporter COG1132 Cluster_610760 V1278327 RPSJ map03010 J Involved in the binding of tRNA to the ribosomes (By similarity) COG0051 Cluster_429136 V1278328 AHPF O Alkyl hydroperoxide reductase COG3634 Cluster_431076 V1278329 FHUD map02010 P Periplasmic binding protein COG0614 Cluster_429137 V1278330 CAS3 L CRISPR-Associated Helicase Cas3 COG1203 Cluster_554999 V1278332 PEPP map00310,map00780,map01100 E peptidase M24 COG0006 Cluster_844388 V1278333 PIP map00330 E Proline imino-peptidase COG0596 Cluster_523342 V1278334 ISPD map00900,map01100,map01110 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COG1211 Cluster_523343 V1278336 SP_0161 K, T lytTr DNA-binding domain protein COG3279 Cluster_523344 V1278337 DAM map03430 L Dna adenine methylase COG0338 Cluster_431077 V1278338 MDH map00620,map00710,map01100,map01120,map02020 C malate dehydrogenase (Oxaloacetate-decarboxylating) COG0281 Cluster_465262 V1278339 map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_492283 V1278340 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_832596 V1278341 map02010 E (ABC) transporter COG4608 Cluster_579796 V1278342 OPPD map02010 E, P ABC transporter COG0444 Cluster_657440 V1278343 GLGC map00500,map00520,map01100,map01110 G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) COG0448 Cluster_766504 V1278345 YJDI S Pfam:DUF1271 COG3592 Cluster_431078 V1278348 UVRD map03420,map03430 L ATP-dependent DNA helicase pcra COG0210 Cluster_431079 V1278349 DNAG map03030 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 Cluster_431080 V1278350 HRCA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) COG1420 Cluster_589514 V1278351 S (LipO)protein 1C848@synNOG Cluster_781413 V1278352 RODA map00550,map04112 D cell cycle protein COG0772 Cluster_670165 V1278353 META map00270,map00920,map01100,map01110,map01230 E Homoserine O-transsuccinylase COG1897 Cluster_431081 V1278354 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_661646 V1278355 YIHP G transporter COG2211 Cluster_431082 V1278357 map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020 C fumarate reductase succinate dehydrogenase flavoprotein domain protein COG1053 Cluster_433096 V1278361 BCD map00071,map00280,map00281,map00650,map01100,map01110 I acyl-CoA dehydrogenase COG1960 Cluster_431083 V1278363 T Histidine kinase 0XNMH Cluster_431084 V1278364 V abc transporter permease protein COG0577 Cluster_431085 V1278365 RSMB J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA (By similarity) COG0144 Cluster_431086 V1278366 NHAC map00680 C Na H antiporter COG1757 Cluster_433097 V1278369 ADDB L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination COG3857 Cluster_567147 V1278371 LYSI E Arginine ornithine antiporter COG0531 Cluster_433098 V1278373 MGTE P magnesium transporter COG2239 Cluster_433099 V1278374 UVRD map03420,map03430 L ATP-dependent DNA helicase pcra COG0210 Cluster_433100 V1278375 NRNA J phosphoesterase RecJ domain protein COG0618 Cluster_674559 V1278376 E, P ABC transporter COG0444 Cluster_731701 V1278377 DPPF E ABC transporter COG4608 Cluster_621875 V1278378 RV3032 map00500 M group 1 glycosyl transferase COG0438 Cluster_653320 V1278379 RPSO map03010 J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) COG0184 Cluster_431087 V1278380 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_621876 V1278381 map00511 G glycoside hydrolase family 38 COG0383 Cluster_431088 V1278382 RNFD C Electron transport complex COG4658 Cluster_433101 V1278386 FEOB P Ferrous iron transport protein B COG0370 Cluster_433102 V1278387 map01053 Q amino acid adenylation COG1020 Cluster_670167 V1278388 NUOL map00190,map00910,map01100 C NADH dehydrogenase subunit l COG1009 Cluster_734952 V1278389 NUOK map00190,map00910,map01100 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) COG0713 Cluster_431089 V1278390 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG2812 Cluster_445077 V1278391 LANM V Lanthionine synthetase C family protein COG4403 Cluster_896593 V1278393 S NA 0ZHU9 Cluster_433104 V1278394 LACZ map00052,map00511,map00600,map01100 G Beta-galactosidase COG3250 Cluster_909293 V1278395 UMUC L ImpB MucB SamB family protein COG0389 Cluster_433105 V1278397 S NA 0XR66 Cluster_515358 V1278398 UDK map00240,map00983,map01100 F uridine kinase COG0572 Cluster_699435 V1278399 map00052,map02060 G PTS system sorbose subfamily IIB component COG3444 Cluster_913545 V1278400 AGAC map00052,map02060 G PTS System COG3715 Cluster_610761 V1278401 DING map00230,map00240,map01100,map03030,map03430,map03440 L helicase COG1199 Cluster_683559 V1278402 YIDC map03060,map03070 U Membrane COG0706 Cluster_433106 V1278403 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_543255 V1278404 RUVX L Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) COG0816 Cluster_433107 V1278405 MTAB map00051,map00363,map00591,map00625,map00650,map01100,map01120 J RNA modification enzyme, MiaB family COG0621 Cluster_711841 V1278406 SUSC P outer membrane protein SusC 0XNNV Cluster_433108 V1278407 AATA map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aminotransferase COG0436 Cluster_435002 V1278409 YHDA T Diguanylate cyclase phosphodiesterase 16RU3@proNOG Cluster_435003 V1278410 ALKA map03410 L 8-oxoguanine DNA glycosylase COG0122 Cluster_435004 V1278411 YHGE S domain protein COG1511 Cluster_482827 V1278412 HOM E saf domain-containing protein COG4091 Cluster_433109 V1278414 S Uncharacterized BCR, YitT family COG1284 COG1284 Cluster_618233 V1278415 S NA 120PT Cluster_435006 V1278416 M NA 0YESU Cluster_433110 V1278417 S NA 0YG1I Cluster_718461 V1278418 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_741675 V1278419 PHNP map00440 S Beta-lactamase domain protein COG1235 Cluster_725109 V1278420 SCLAV_4722 J Methyltransferase COG2813 Cluster_711842 V1278421 YHCG S Protein of unknown function (DUF1016) COG4804 Cluster_461066 V1278426 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_445078 V1278427 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_433111 V1278430 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_433112 V1278432 V Mate efflux family protein COG0534 Cluster_510064 V1278433 S NA 1262Z Cluster_435008 V1278437 HSDS V restriction modification system DNA specificity domain COG0732 Cluster_884438 V1278438 RBFA J Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) COG0858 Cluster_546187 V1278439 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_492284 V1278441 BPET1060 L DNA polymerase COG3344 Cluster_637257 V1278442 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_755235 V1278444 HEMN map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_653321 V1278445 DUSB J Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_435009 V1278446 PATB map00270,map00450,map00920,map01100,map01110,map01230 E Aminotransferase class I and II COG1168 Cluster_485145 V1278448 S conserved repeat domain protein 0ZW39 Cluster_435010 V1278449 SBCC L Exonuclease COG0419 Cluster_435011 V1278450 map00500,map00511,map01100 N Alpha-L-fucosidase 0XPGV Cluster_683560 V1278451 C Molybdopterin-binding domain of aldehyde dehydrogenase COG1529 Cluster_435012 V1278452 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_435013 V1278456 APEA map00480,map01100 E M18 family aminopeptidase COG1362 Cluster_435014 V1278457 P TonB-dependent receptor plug 0XNNV Cluster_821040 V1278458 M Auxiliary transport protein, membrane fusion protein COG0845 Cluster_687997 V1278459 M Outer membrane efflux protein COG1538 Cluster_711843 V1278461 B, K radical SAM domain protein COG1243 Cluster_478100 V1278462 RV2219 S integral membrane protein 0Z3WW Cluster_435015 V1278463 S domain protein 0XPXI Cluster_435016 V1278464 YYBT T domain protein COG3887 Cluster_435017 V1278465 MANX map00051,map00520,map01100,map02060 G pts system COG3444 Cluster_728435 V1278466 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_817155 V1278467 ISCR K Transcriptional regulator, BadM Rrf2 family COG1959 Cluster_435018 V1278468 AMAA map00360 E Peptidase dimerisation domain COG1473 Cluster_583044 V1278469 M n-acetylmuramoyl-l-alanine amidase COG5632 Cluster_840355 V1278470 ELI_3039 K RNA Polymerase 1261F Cluster_445079 V1278471 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_603496 V1278472 RNHB map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0164 Cluster_435019 V1278473 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_512639 V1278474 M NLP P60 protein COG0791 Cluster_482828 V1278475 GNTP E, G Citrate transporter COG2610 Cluster_435020 V1278476 P Transporter COG0733 Cluster_435021 V1278477 BL01965 S trap transporter, 4tm 12tm fusion protein COG4666 Cluster_512640 V1278478 V ABC transporter COG1131 Cluster_435022 V1278479 ISPA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_534642 V1278480 HBD map00360,map00362,map00650,map01100,map01120 C 3-hydroxybutyryl-CoA dehydrogenase COG1250 Cluster_435023 V1278481 S s-layer domain-containing protein 11ZJU Cluster_435024 V1278482 FADD map00071,map01100,map03320,map04146,map04920 I Long-chain-fatty-acid--CoA ligase COG1022 Cluster_649238 V1278483 S Cupin 2 Conserved Barrel Domain Protein COG1917 Cluster_435025 V1278485 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_435026 V1278486 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_473720 V1278488 P membrane 0XNNV Cluster_435027 V1278489 RNFC C Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) COG4656 Cluster_435028 V1278490 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_678992 V1278492 RPLW map03010 J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) COG0089 Cluster_758736 V1278493 RPLD map03010 J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) COG0088 Cluster_657441 V1278494 HGDA map00362,map01100,map01120,map01220 E dehydratase COG1775 Cluster_435029 V1278495 SBCC L Exonuclease COG0419 Cluster_437073 V1278496 S trap transporter, 4tm 12tm fusion protein COG4666 Cluster_589515 V1278497 V (ABC) transporter 0XQRE Cluster_451128 V1278499 map00052,map02060 G PTS system sorbose subfamily IIB component COG3444 Cluster_435030 V1278500 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_557916 V1278501 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E amino acid aminotransferase COG0115 Cluster_437074 V1278504 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_755236 V1278505 SP_0899 S Membrane Associated 114SZ Cluster_683562 V1278506 S Acetyltransferase (GNAT) family 0ZWSW Cluster_437075 V1278507 ARCA map00330,map01100,map01110 E Arginine dihydrolase COG2235 Cluster_809430 V1278508 MURE map00300,map00550 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_435031 V1278509 NTPC map00190,map00680,map01100 C ATP synthase subunit C COG1527 Cluster_437076 V1278510 YOCR P transporter COG0733 Cluster_618234 V1278512 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_543256 V1278513 OPPD map02010 E, P ABC transporter COG0444 Cluster_437077 V1278516 LTRBE1 U relaxase mobilization nuclease domain protein COG3843 Cluster_435032 V1278517 ABPB map00310,map00780,map01100 E Dipeptidase COG4690 Cluster_543257 V1278519 TAGE M peptidase COG0739 Cluster_678993 V1278520 S NA 0Z4BV Cluster_437078 V1278522 BA_0689 E Transporter COG3104 Cluster_437079 V1278525 PAP L polyphosphate kinase 2 COG2326 Cluster_563945 V1278526 RPSH map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) COG0096 Cluster_696156 V1278527 map02010 V ABC transporter COG1131 Cluster_896594 V1278528 SCLAV_4303 S Abc transporter integral membrane protein 11ZWC Cluster_437080 V1278529 S Glucan-binding protein C 1001J Cluster_437081 V1278530 OADB map00330,map00620,map01100 C decarboxylase (Beta subunit) COG1883 Cluster_437082 V1278531 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_437083 V1278533 S phospholipase COG4667 Cluster_451129 V1278534 L Site-specific recombinase COG1961 Cluster_437084 V1278535 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G phosphohexokinase COG0205 Cluster_437085 V1278536 S NA 0Z7KY Cluster_437086 V1278537 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_437087 V1278538 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_603498 V1278541 S Transcriptional regulator 11G4D Cluster_607106 V1278542 AGRA map02020 T response regulator COG3279 Cluster_478101 V1278544 THID map00730,map01100 H phosphomethylpyrimidine kinase COG0351 Cluster_439088 V1278545 NHAC map00680 C Na H antiporter COG1757 Cluster_482829 V1278546 GLPG S Rhomboid family COG0705 Cluster_537533 V1278547 C domain protein COG0426 Cluster_453061 V1278548 NADD map00230,map00760,map01100,map05340 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) COG1057 Cluster_437089 V1278549 GLGC map00500,map00520,map01100,map01110 G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) COG0448 Cluster_437090 V1278550 SP_1914 S Cell wall-active antibiotics response protein (DUF2154) 11V5T Cluster_437091 V1278551 BL01171 P hemerythrin hhe cation binding domain protein COG2461 Cluster_437092 V1278553 S NA 0XSI9 Cluster_437093 V1278556 HPRK T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) COG1493 Cluster_482830 V1278557 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_512641 V1278558 MRDB D Rod shape-determining protein rodA COG0772 Cluster_437094 V1278562 S ybbr family COG4856 Cluster_515359 V1278563 RHOM_13740 I Phospholipase D domain protein COG1502 Cluster_437095 V1278564 T Histidine kinase 0XNMH Cluster_439091 V1278565 VPA1266 map03440 L Helicase, RecD TraA family COG4932 Cluster_465263 V1278566 NIFJ map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map00910,map01100,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_455074 V1278568 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_439092 V1278569 S Phage tail tape measure protein, TP901 family 10QPB Cluster_437096 V1278570 AHPF O Alkyl hydroperoxide reductase COG3634 Cluster_463176 V1278572 L TatD-related deoxyribonuclease COG0084 Cluster_492285 V1278574 M glycosyltransferase group 2 family protein COG0463 Cluster_437097 V1278575 S NA 11W9N Cluster_567148 V1278579 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_439093 V1278580 ALIB2 map02010 E Oligopeptide-binding protein COG4166 Cluster_520602 V1278583 DACF map00550,map01100 M carboxypeptidase COG1686 Cluster_439094 V1278584 PBP2B map00550,map01100 M penicillin-binding protein COG0768 Cluster_439095 V1278585 P TonB-dependent receptor plug 0XNNV Cluster_852073 V1278586 S Membrane COG2339 Cluster_461067 V1278587 YIAO G transporter COG1638 Cluster_439096 V1278588 S secreted protein COG4880 Cluster_515360 V1278589 ALGI M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_537534 V1278590 S Nitrogen regulatory protein P-II 11PAT Cluster_439097 V1278595 COMEC S DNA internalization-related competence protein ComEC Rec2 COG2333 Cluster_439098 V1278598 M Polysaccharide biosynthesis protein COG1087 Cluster_560967 V1278599 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily COG1368 Cluster_563946 V1278601 BMUL_1547 K Transcriptional regulator 0XUB6 Cluster_445080 V1278603 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_441079 V1278604 map00860,map01100 H cobaltochelatase, cobn subunit COG1429 Cluster_549219 V1278605 THRS map00020,map00300,map00630,map00720,map01100,map01110,map01120,map01210,map01230 C Aconitate hydratase COG1048 Cluster_439099 V1278607 T Histidine kinase 0XNMH Cluster_441080 V1278608 PPPA map03070 T phosphatase COG0631 Cluster_439100 V1278609 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_497278 V1278610 CCPA K Transcriptional regulator, LacI family COG1609 Cluster_702472 V1278611 map02010 V Abc transporter COG1132 Cluster_441081 V1278612 S NA 11FRY Cluster_653322 V1278614 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_785502 V1278615 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_549220 V1278616 map00020,map00190,map00623,map00650,map00720,map00920,map01100,map01110,map01120,map05134 C Succinate dehydrogenase (Flavoprotein subunit) COG1053 Cluster_529015 V1278618 PSTB2 map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_441082 V1278620 E amidohydrolase COG1473 Cluster_502478 V1278622 S filamentation induced by cAMP protein Fic COG3177 Cluster_718462 V1278627 LDHA map00620 C d-lactate dehydrogenase COG1052 Cluster_439101 V1278629 S tetratricopeptide 11K7N Cluster_614484 V1278630 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_465264 V1278632 S NA 0ZCXG Cluster_610762 V1278633 S Nad-dependent epimerase dehydratase 0ZIPB Cluster_844390 V1278634 GLTS E Sodium Glutamate Symporter COG0786 Cluster_489789 V1278638 map02010 V ABC transporter COG1131 Cluster_485146 V1278639 DCTP C symporter COG1301 Cluster_494770 V1278641 PHOP map02020 T response regulator 11FPD Cluster_441083 V1278642 V abc transporter permease protein COG0577 Cluster_441084 V1278643 S Membrane COG3949 Cluster_441085 V1278645 BL01171 P hemerythrin hhe cation binding domain protein COG2461 Cluster_441086 V1278646 S NA 11FGU Cluster_441087 V1278647 S NA 11ZCV Cluster_441088 V1278649 S Inherit from NOG: Phosphate-Selective Porin O and P 0XQB1 Cluster_441089 V1278650 U MotA TolQ exbB proton channel COG0811 Cluster_683563 V1278651 THA_2007 L Transposase COG2801 Cluster_832598 V1278652 PHBA map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map02020 I acetyl-CoA COG0183 Cluster_441090 V1278653 P Outer membrane protein probably involved in nutrient binding 0XNNV Cluster_699436 V1278654 K Transcriptional regulator, TetR family 11IY2 Cluster_589517 V1278657 CMR G multi-drug 173VC@proNOG Cluster_502479 V1278661 LYSP E permease COG0833 Cluster_441091 V1278662 SGAU map00040,map00053,map01100,map01120 G L-xylulose 5-phosphate 3-epimerase COG3623 Cluster_441092 V1278663 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_463177 V1278664 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_443086 V1278667 OORA map00020,map00720,map01100,map01120 C 2-oxoglutarate acceptor oxidoreductase COG0674 Cluster_485147 V1278670 P TrkA-N domain protein COG1226 Cluster_441093 V1278671 S NA 0XWEM Cluster_443087 V1278672 LACE map00052,map01100,map02060 G pts system, lactose-specific COG1455 Cluster_441094 V1278673 M Inherit from NOG: domain protein 0XQTW Cluster_603500 V1278676 MGSA map00620 G methylglyoxal synthase COG1803 Cluster_443088 V1278679 S NA 0ZUV1 Cluster_696158 V1278680 YFCE S Phosphodiesterase COG0622 Cluster_443089 V1278681 ALLD map00230,map01120 C Ureidoglycolate dehydrogenase COG2055 Cluster_607107 V1278683 YCGI U ATP-binding component of a transport system 16SGG@proNOG Cluster_579797 V1278684 RNMV L Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) COG1658 Cluster_443090 V1278686 TREB map00010,map00500,map00520,map02060 G PTS System COG1264 Cluster_557917 V1278688 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_657442 V1278690 VIRE L Virulence-associated protein e COG5545 Cluster_840356 V1278691 L CHC2 zinc finger domain protein COG0358 Cluster_443091 V1278693 S NA 0XRGD Cluster_482832 V1278694 S radical SAM domain protein COG0535 Cluster_607108 V1278696 ATPA map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_443093 V1278697 METY map00270,map00450,map00920,map01100,map01110,map01230 E Cys/Met metabolism PLP-dependent enzyme COG2873 Cluster_443094 V1278698 S (LipO)protein 0XSYT Cluster_576673 V1278699 M Peptidase family S41 COG0793 Cluster_641255 V1278700 S NA 1259M Cluster_443095 V1278701 map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020 C fumarate reductase succinate dehydrogenase flavoprotein domain protein COG1053 Cluster_492286 V1278703 ATPF map00190,map00195,map01100 M Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) 11RTE Cluster_443096 V1278704 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_478102 V1278707 CCA map03013,map03018 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate COG0617 Cluster_443097 V1278709 SSTT E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) COG3633 Cluster_560968 V1278710 BISZ map00780,map01100 C Biotin sulfoxide reductase COG0243 Cluster_443098 V1278711 S NA 11NI8 Cluster_443099 V1278712 YEIH S Membrane COG2855 Cluster_526256 V1278715 PCCB map00280,map00630,map00640,map00720,map01100,map01120 I carboxyl transferase domain protein COG4799 Cluster_758737 V1278716 REX K Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) COG2344 Cluster_687999 V1278717 UUP S Abc transporter, ATP-binding protein COG0488 Cluster_480485 V1278718 YACP J Tetracycline resistance protein COG3688 Cluster_443100 V1278719 LDHA map00030,map00620,map01100,map01120 C Dehydrogenase COG1052 Cluster_725110 V1278720 RPME2 map03010 J 50s ribosomal protein l31 type b COG0254 Cluster_443101 V1278721 S Helix-turn-helix 0YAU0 Cluster_621877 V1278724 S amidinotransferase COG4874 Cluster_557918 V1278725 FOLE map00790,map01100 H GTP cyclohydrolase i COG0302 Cluster_443103 V1278726 SURE map00230,map00240,map00760,map01100,map01110 F Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) COG0496 Cluster_469472 V1278727 GBPR K LysR family transcriptional Regulator 1758P@proNOG Cluster_699437 V1278729 S Pfam:DUF1200 0YA60 Cluster_443104 V1278730 T response regulator COG0745 Cluster_443105 V1278731 M domain protein COG4932 Cluster_455076 V1278732 LON map04112 O ATP-dependent Lon protease COG4930 Cluster_546188 V1278733 THIM map00730,map01100 H 4-methyl-5-beta-hydroxyethylthiazole kinase COG2145 Cluster_445081 V1278735 PHOR map02020 T Histidine kinase 0XNMH Cluster_499946 V1278737 GLNP E Abc transporter COG0834 Cluster_443106 V1278738 CLFA map05150 M Cell surface-associated protein implicated in virulence. Promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen. Induces formation of bacterial clumps 0Y59N Cluster_465265 V1278739 WS0013 S membrAne 0XPGN Cluster_744980 V1278740 S Phospholipase, patatin family 0YEF4 Cluster_855850 V1278741 SACC map00052,map00500,map01100 G sucrose-6-phosphate hydrolase COG1621 Cluster_463178 V1278742 L Transposase 121D1 Cluster_445082 V1278743 PEPR map00310,map00780,map01100 O peptidase, M16 COG0612 Cluster_443107 V1278745 S integral membrane protein COG0730 Cluster_443108 V1278747 L Terminase, large subunit COG4626 Cluster_445083 V1278749 M NA 0YESU Cluster_445084 V1278750 S Inherit from NOG: repeat protein 11TEE Cluster_445085 V1278751 E amidohydrolase COG1473 Cluster_443109 V1278752 O cysteine protease COG4870 Cluster_445086 V1278753 EVGS map02020,map05133 T Histidine kinase COG2198 Cluster_443110 V1278754 AGCS E amino acid carrier protein COG1115 Cluster_445087 V1278755 S NA 11NI8 Cluster_629375 V1278756 DPS P Ferritin, Dps family protein COG0783 Cluster_603501 V1278758 HYDF S gtp-binding protein COG1160 Cluster_534644 V1278759 RSMB J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA (By similarity) COG0144 Cluster_445088 V1278760 FEOB P Ferrous iron transport protein B COG0370 Cluster_540325 V1278761 S NA 0ZHU9 Cluster_445089 V1278762 WECB map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_563947 V1278763 S Domain of unknown function (DUF1836) 0ZWQ6 Cluster_586231 V1278764 S NA 11RAY Cluster_445090 V1278767 YFGQ P ATPase, P-type (Transporting), HAD superfamily, subfamily IC COG0474 Cluster_552109 V1278768 GLNS map00970,map01100 J glutaminyL-tRNA synthetase COG0008 Cluster_731702 V1278769 SCLAV_3826 S aig2 family 11IGG Cluster_625675 V1278770 M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) COG4623 Cluster_805403 V1278771 UDK map00240,map00983,map01100 F uridine monophosphokinase COG0572 Cluster_445091 V1278772 MALQ map00500,map01100 G 4-alpha-glucanotransferase COG1640 Cluster_445092 V1278773 S hi0933 family COG2081 Cluster_555000 V1278775 K RNA Polymerase COG1595 Cluster_445093 V1278780 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_821042 V1278781 S Membrane COG2119 Cluster_445094 V1278783 YLBM S UPF0348 protein COG1323 Cluster_445095 V1278784 M mechanosensitive ion channel (MscS) COG3264 Cluster_678994 V1278785 YHCC S Radical SAM Protein COG1242 Cluster_445096 V1278786 MIAB J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) COG0621 Cluster_793297 V1278788 CELA map02060 G PTS System COG1440 Cluster_711844 V1278789 P Chromate COG2059 Cluster_557919 V1278790 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_445097 V1278791 S tonB-dependent Receptor 0XNVP Cluster_534645 V1278792 ASCB map00010,map00460,map00500,map00940,map01100,map01110 G 6-phospho-beta-glucosidase COG2723 Cluster_925767 V1278793 ASCF map00010,map00500,map00520,map02060 G PTS system cellobiose arbutin salicin-specific transporter COG1264 Cluster_445098 V1278794 AGUB map00330,map01100 S hydrolase, carbon-nitrogen family COG0388 Cluster_445099 V1278796 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0047 Cluster_445100 V1278797 M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_445101 V1278798 RFAG map00051 M glycosyltransferase group 2 family protein COG0463 Cluster_534646 V1278799 P membrAne COG2717 Cluster_607110 V1278800 CDR map00190 P pyridine nucleotide-disulfide oxidoreductase COG0607 Cluster_445102 V1278801 PEPP E peptidase, M24 COG0006 Cluster_520604 V1278803 S Protein of unknown function (DUF3375) 0XQSA Cluster_445104 V1278808 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_683564 V1278810 CUPIN S Cupin 2, conserved barrel domain protein 123EC Cluster_447134 V1278811 BIOA map00780,map01100 H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) COG0161 Cluster_447135 V1278812 RV3193C S UPF0182 protein COG1615 Cluster_797263 V1278814 K FCD COG1802 Cluster_447136 V1278815 BL03502 O phage portal protein HK97 family COG4695 Cluster_445105 V1278816 S ABC transporter, ATP-binding protein COG0488 Cluster_447137 V1278817 SP_1331 K transcriptional regulator COG1737 Cluster_543258 V1278819 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_607111 V1278820 BGLB map00010 G Glycosyl hydrolase family 1 COG2723 Cluster_447138 V1278821 XERC L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_499947 V1278822 S Gp157 family 11ZXY Cluster_610764 V1278823 MANO S Domain of unknown function (DUF956) COG4687 Cluster_872165 V1278826 S Phage terminase small subunit 11F23 Cluster_718463 V1278827 LYSA map00300,map01100,map01110,map01120,map01230 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) COG0019 Cluster_447139 V1278828 K Transcriptional regulator COG1396 Cluster_447140 V1278829 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_637259 V1278830 S Structural protein 11PKS Cluster_589518 V1278832 G s-layer domain protein 11MJ3 Cluster_567149 V1278833 HYDE map00780,map01100 H radical SAM domain protein COG0502 Cluster_492287 V1278834 S Phage major tail protein 2 0XU4M Cluster_777601 V1278837 CARD K Transcriptional regulator (CarD family COG1329 Cluster_447142 V1278839 DPNA L helicase COG4646 Cluster_683565 V1278840 M glycosyltransferase COG0438 Cluster_725111 V1278841 CPOA M Glycosyl transferase COG0438 Cluster_447143 V1278842 THIP map02010 P binding-protein-dependent transport systems inner membrane Component COG1178 Cluster_447144 V1278843 FTSK D cell division protein FtsK COG1674 Cluster_683566 V1278844 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_880312 V1278845 YBIT S ABC transporter, ATP-binding protein COG0488 Cluster_447145 V1278846 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_447146 V1278847 FCHA map00670,map01100 E Methenyltetrahydrofolate cyclohydrolase COG3404 Cluster_447147 V1278849 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_447148 V1278851 S Domain of unknown function (DUF1858) 129SC Cluster_447149 V1278852 CP_0141 S metallophosphoesterase COG1768 Cluster_797264 V1278853 SLYX S Protein slyX homolog COG2900 Cluster_447150 V1278854 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_447151 V1278855 M Glycosyl transferase, family 2 COG1216 Cluster_809431 V1278856 S NA 11VH5 Cluster_449145 V1278858 COMEC S Competence protein COG2333 Cluster_449146 V1278859 YPDP S Membrane COG1738 Cluster_586233 V1278860 SSCG_06117 S degv family COG1307 Cluster_447152 V1278861 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase ii COG0046 Cluster_447153 V1278862 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_447154 V1278863 S Inherit from COG: ATPase (AAA COG1373 Cluster_543259 V1278864 FLD C Flavodoxin COG0716 Cluster_447155 V1278865 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_447156 V1278866 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_731703 V1278870 map02010,map02020,map05152 P phosphate COG0226 Cluster_699438 V1278871 ADE map00230,map01100 F adenine deaminase COG1001 Cluster_449147 V1278872 PGM map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_560969 V1278874 YMCB S Pfam:DUF1017 17BXH@proNOG Cluster_447157 V1278875 map00140,map00600 P Arylsulfatase COG3119 Cluster_447158 V1278876 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_463179 V1278877 ADK map00230,map00240,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_449148 V1278879 M peptidase M23 COG0739 Cluster_447159 V1278880 S NA 11VIT Cluster_449149 V1278881 S NA 0YWBS Cluster_449150 V1278882 GLYQ map00970 J glycyl-tRNA synthetase, alpha subunit COG0752 Cluster_447160 V1278883 GLGB map00500,map01100,map01110 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) COG0296 Cluster_449151 V1278885 IRP P tonB-dependent Receptor COG1629 Cluster_864207 V1278886 LPTB map02010 S ABC transporter COG1137 Cluster_463180 V1278888 V Mate efflux family protein COG0534 Cluster_449152 V1278889 YXCA I coA-substrate-specific enzyme activase COG3581 Cluster_583045 V1278890 PEPN map00480,map01100 E Aminopeptidase COG0308 Cluster_497279 V1278891 PHOU P Plays a role in the regulation of phosphate uptake COG0704 Cluster_449153 V1278892 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_661647 V1278893 E Family 5 COG0747 Cluster_449154 V1278894 CSTA T carbon starvation protein COG1966 Cluster_497280 V1278895 FTSQ map04112 M domain protein, FtsQ-type COG1589 Cluster_480486 V1278899 S NA 11QVU Cluster_473721 V1278901 G Major facilitator superfamily MFS_1 COG0477 Cluster_449156 V1278902 S NA 0YH2T Cluster_821043 V1278903 YHAM S UPF0597 protein COG3681 Cluster_449157 V1278904 YIAV V secretion protein, HlyD family COG1566 Cluster_449158 V1278905 YDCQ D ftsk SpoIIIE family protein COG1674 Cluster_510066 V1278907 RSEP map04112 M Membrane-associated zinc metalloprotease COG0750 Cluster_473722 V1278908 THRC map00260,map00750,map01100,map01120,map01230 E Threonine synthase COG0498 Cluster_683567 V1278909 ATPD map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG1394 Cluster_777602 V1278910 ATPB map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) COG1156 Cluster_683568 V1278913 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_755237 V1278914 GLYQ map00970 J glycyl-tRNA synthetase, alpha subunit COG0752 Cluster_592920 V1278916 OPPF map02010 E (ABC) transporter COG4608 Cluster_455077 V1278918 M peptidase COG0739 Cluster_492288 V1278919 FTSI map00550,map01100 M penicillin-binding protein COG0768 Cluster_657443 V1278920 SP_0119 L Nudix family COG0494 Cluster_507465 V1278922 FDA map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01230 G fructose-bisphosphate aldolase COG3588 Cluster_451131 V1278923 PEPA map00480,map01100 E Probably plays an important role in intracellular peptide degradation (By similarity) COG0260 Cluster_449160 V1278924 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_449161 V1278925 THRC map00260,map00750,map01100,map01120,map01230 E Threonine synthase COG0498 Cluster_449163 V1278927 S NA 0YABK Cluster_449164 V1278928 NFED O nodulation efficiency protein D COG1030 Cluster_449165 V1278929 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_451132 V1278930 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_449166 V1278931 S NA 0XWHS Cluster_449167 V1278932 map02010 P abc-3 protein COG1108 Cluster_583046 V1278933 Q Acetyl xylan esterase (AXE1) COG3458 Cluster_449168 V1278936 M Peptidase M15B and M15C DD-carboxypeptidase VanY, endolysin 11NIG Cluster_512642 V1278937 S RNA polymerase sigma factor, sigma-70 family 11JZP Cluster_741676 V1278938 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_451133 V1278939 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G phosphohexokinase COG0205 Cluster_451134 V1278940 RPE map00030,map00040,map00710,map01100,map01110,map01120,map01230 G ribulose-phosphate 3-epimerase COG0036 Cluster_534647 V1278942 S Dehydrogenase reductase COG1028 Cluster_451135 V1278943 EPD map00010,map00281,map00626,map00750,map00903,map01100,map01110,map01120,map01230,map04066,map05010 G Glyceraldehyde-3-phosphate dehydrogenase COG0057 Cluster_523345 V1278944 map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) COG1156 Cluster_451136 V1278946 C Hydrogenase large subunit domain protein COG4624 Cluster_451137 V1278947 MAHAU_0136 L Integrase catalytic subunit 0XPD4 Cluster_489790 V1278948 CPSY map00052,map00520,map01100,map01110 S capsular polysaccharide phosphotransferase 0XYNB Cluster_451138 V1278949 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_451139 V1278950 YCCC map00250,map00330,map00460,map00471,map00910,map01100,map01110,map01120,map02020 E L-asparaginase COG0252 Cluster_451140 V1278951 G abc transporter integral membrane protein COG1172 Cluster_451141 V1278953 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_734953 V1278954 RSEP map04112 M Membrane-associated zinc metalloprotease COG0750 Cluster_728437 V1278956 LDH map00010,map00051,map00270,map00363,map00591,map00620,map00625,map00640,map00650,map01100,map01110,map01120 C Dehydrogenase COG0039 Cluster_451143 V1278958 C formyl-CoA transferase COG1804 Cluster_573465 V1278959 RUMAL_0348 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_451144 V1278961 S NA 10HN9 Cluster_451145 V1278962 YDCQ D ftsk SpoIIIE family protein COG1674 Cluster_610765 V1278964 S NA 0YD8B Cluster_451146 V1278965 V abc transporter permease protein 0ZW5X Cluster_552110 V1278966 C radical SAM domain protein COG1032 Cluster_451147 V1278967 NRDB map00230,map00240,map00480,map01100,map04115 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_451148 V1278968 SAGG map02010 V ABC transporter, ATP-binding protein COG1131 Cluster_453062 V1278970 FBP map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120 G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 COG3855 Cluster_670169 V1278971 NAGE map00010,map00500,map00520,map02060 G PTS System COG1264 Cluster_451149 V1278972 PPDK map00620,map00710,map01100,map01120 G Pyruvate phosphate dikinase COG0574 Cluster_607112 V1278973 S NA 0ZY1A Cluster_453063 V1278974 GGT map00430,map00460,map00480,map00590,map01100 E gamma-glutamyltransferase COG0405 Cluster_758738 V1278975 CATR K regulator Fur family COG0735 Cluster_748325 V1278976 YEIH S Membrane COG2855 Cluster_825015 V1278979 METX map00270,map00920,map01100 E Homoserine O-trans-acetylase COG2021 Cluster_641256 V1278980 BMUL_5873 S gtp-binding protein COG1306 Cluster_453064 V1278981 S Membrane COG2966 Cluster_715200 V1278982 SCRR K Sucrose operon repressor COG1609 Cluster_480487 V1278983 S NA 12CHY Cluster_451150 V1278985 S M protein-like MukB domain-containing protein COG4913 Cluster_451151 V1278986 S Relaxase mobilization nuclease 0Y9PG Cluster_451152 V1278988 I protein, conserved in bacteria COG3581 Cluster_665859 V1278990 S phage protein 0XQDU Cluster_453065 V1278992 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_453066 V1278995 S NA 0XYCW Cluster_451153 V1278996 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_738279 V1278997 S Nitroreductase 11NZA Cluster_637260 V1278998 THIE map00730,map01100 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) COG0352 Cluster_451154 V1278999 FBPA K Fibronectin-binding protein COG1293 Cluster_801240 V1279000 L NA 11GDS Cluster_748326 V1279001 L NA 11GDS Cluster_738280 V1279004 S Uncharacterized BCR, YitT family COG1284 COG1284 Cluster_453068 V1279007 S Domain of unknown function (DUF348) COG3583 Cluster_512643 V1279008 L Resolvase, N-terminal domain protein COG1961 Cluster_507466 V1279011 PHOR T Histidine kinase 0XNMH Cluster_453069 V1279012 S Ragb susd domain-containing protein 0XTE0 Cluster_453070 V1279014 METK S methionine adenosyltransferase 0YTXD Cluster_453071 V1279015 YXCA I coA-substrate-specific enzyme activase COG3581 Cluster_844393 V1279016 S NA 0YEGC Cluster_453072 V1279017 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_844394 V1279018 I Lipid kinase, YegS Rv2252 BmrU family COG1597 Cluster_455078 V1279020 THII map00730,map01100,map04122 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) COG0301 Cluster_455079 V1279021 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_738281 V1279022 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_715201 V1279024 PYRB map00240,map00250,map01100 F aspartate transcarbamylase COG0540 Cluster_573467 V1279025 PRDB map00330 S d-proline reductase 11J2N Cluster_453073 V1279027 YYBT T domain protein COG3887 Cluster_455080 V1279028 E peptidase, M24 COG0006 Cluster_688000 V1279029 YEIH S Membrane COG2855 Cluster_461068 V1279031 PROTEASE map05120 O Peptidase U32 COG0826 Cluster_471625 V1279032 YDED E, G Membrane COG0697 Cluster_455081 V1279033 SUN J ribosomal RNA small subunit methyltransferase COG0144 Cluster_453074 V1279035 ACDA map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I Acyl-CoA dehydrogenase, N-terminal domain COG2025 Cluster_453075 V1279036 TYPA T gtp-binding protein typa COG1217 Cluster_510067 V1279037 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_455083 V1279038 NLPD M peptidase M23 COG0739 Cluster_467353 V1279039 E Family 5 COG0747 Cluster_696160 V1279043 FABB map00061,map00780,map01100 Q synthase COG0304 Cluster_770212 V1279044 FABG3 map00061,map00780,map01040,map01100 S reductase 0XNW1 Cluster_583047 V1279047 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_549221 V1279049 S conjugative transposon protein TraO 0YYJU Cluster_520605 V1279052 S Inherit from NOG: Histidine triad protein 11G35 Cluster_773914 V1279053 PGN_0055 S NA 11YX6 Cluster_455086 V1279054 FADD map00071,map01100,map03320,map04146,map04920 I AMP-binding enzyme COG1022 Cluster_458995 V1279055 CADA P p-type atpase COG2217 Cluster_455087 V1279057 map00040,map01100 G Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) COG2160 Cluster_512644 V1279058 K ParB-like COG1475 Cluster_455088 V1279061 PFK map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G K00850 6-phosphofructokinase 1 EC 2.7.1.11 COG0205 Cluster_455089 V1279063 S NA 113IS Cluster_455090 V1279064 S B3_4 COG3382 Cluster_848280 V1279066 ARGF map00330,map01100,map01110,map01230 E ornithine carbamoyltransferase COG0078 Cluster_738282 V1279067 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_455091 V1279069 ARSB P arsenicaL-resistance protein COG0798 Cluster_455092 V1279070 ASTA S Arylsulfotransferase 174ZE@proNOG Cluster_455093 V1279071 NT5E map00230,map00240,map00630,map00760,map01100,map01110 S Hydrolase COG0546 Cluster_482833 V1279072 THIH map00730,map01100 H biosynthesis protein thiH COG1060 Cluster_455094 V1279073 BMUL_4296 G Major facilitator superfamily COG0477 Cluster_797265 V1279075 HEMN map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_546189 V1279076 ORF1 S NA 17C0T@proNOG Cluster_905226 V1279077 NIFU-LIKE O nitrogeN-fixing nifu domain protein COG0694 Cluster_896595 V1279078 ARGS map00970 J arginyL-tRNA synthetase COG0018 Cluster_523346 V1279080 RUVA map03440 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) COG0632 Cluster_455095 V1279081 YIJF S NADH ubiquinone oxidoreductase COG3738 Cluster_637261 V1279082 T Two component transcriptional regulator, winged helix family COG0745 Cluster_876273 V1279083 PTSH G phosphocarrier protein (HPr COG1925 Cluster_748327 V1279084 SUFC O feS assembly ATPase SufC COG0396 Cluster_455096 V1279085 S gumn family COG3735 Cluster_457017 V1279086 V FtsX-like permease family 0ZZC8 Cluster_555001 V1279087 S Structural protein 11U4Z Cluster_455097 V1279088 SFUB map02010 P transporter (permease) COG1178 Cluster_457018 V1279089 GLPC map00564 C glycerol-3-phosphate dehydrogenase, anaerobic, C subunit COG0247 Cluster_471626 V1279092 HYBB C hydrogenase 2 b cytochrome subunit COG5557 Cluster_457019 V1279093 LACD map00052,map01100 G Aldolase COG3684 Cluster_497282 V1279094 UGD map00040,map00053,map00500,map00520,map01100,map01110 M Udp-glucose 6-dehydrogenase COG1004 Cluster_518030 V1279095 T response regulator COG0745 Cluster_458996 V1279096 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_728439 V1279097 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_728440 V1279098 SLGD_00086 S Ser Thr phosphatase family protein COG1409 Cluster_603503 V1279099 RPSG map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) COG0049 Cluster_586234 V1279100 KTRA P domain protein COG0569 Cluster_674560 V1279102 NADE map00760,map01100 H Nad synthetase COG0388 Cluster_455098 V1279103 S AAA-ATPase 0XQ4X Cluster_455099 V1279105 GNTP P gluconate transport system permease 3 COG2610 Cluster_457020 V1279106 ADE map00230,map01100 F adenine deaminase COG1001 Cluster_557920 V1279107 T cyclic nucleotide-binding domain protein COG0664 Cluster_507467 V1279108 V ABC transporter, ATP-binding protein COG1132 Cluster_670170 V1279109 S EpsK domain protein 0XPSU Cluster_781417 V1279110 M Glycosyl transferase (Group 1 COG0438 Cluster_621878 V1279111 C flavodoxin family COG0716 Cluster_455100 V1279112 MRAY map00550,map01100 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) COG0472 Cluster_683569 V1279113 G C4-dicarboxylate transport system permease small protein COG3090 Cluster_457021 V1279115 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_596394 V1279116 S membrAne 11GVZ Cluster_526258 V1279118 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_485149 V1279119 TAUC map02010 P binding-protein-dependent transport systems inner membrane Component COG0600 Cluster_457022 V1279121 M Sulfatase COG1368 Cluster_510068 V1279122 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_864208 V1279123 K transcriptional regulator, merr family COG0789 Cluster_592921 V1279124 map00010,map00051,map00071,map00350,map00363,map00591,map00625,map00626,map00650,map00830,map00980,map00982,map01100,map01110,map01120 C Dehydrogenase COG1454 Cluster_457023 V1279125 map02010 V Abc transporter COG1132 Cluster_504892 V1279126 SUCC map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120 C Succinyl-CoA synthetase subunit beta COG0045 Cluster_512645 V1279127 GPMA map00010,map00260,map00680,map01100,map01110,map01120,map01230 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0588 Cluster_467354 V1279129 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0587 Cluster_766507 V1279130 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_629376 V1279132 APF1 S Lysm domain protein 11U6T Cluster_576675 V1279133 Z1159 L Pfam:Transposase_8 12B6S Cluster_465266 V1279135 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_529016 V1279136 NORM V Mate efflux family protein COG0534 Cluster_457024 V1279138 SPR M NLP P60 protein COG0791 Cluster_457025 V1279139 ISPB map00900,map01110 H synthase COG0142 Cluster_457026 V1279140 NNRD G Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) COG0063 Cluster_457027 V1279141 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase ii COG0046 Cluster_465267 V1279142 GTSA map02010 E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COG3842 Cluster_758739 V1279143 M Inherit from NOG: Gram positive anchor 11HQ6 Cluster_457028 V1279144 L DNA methylase COG2189 Cluster_487441 V1279145 map00010,map00030,map00051,map00052,map00680,map00710,map01100,map01110,map01120,map01230 G Aldolase COG0191 Cluster_457029 V1279146 DPNA L helicase COG4646 Cluster_457030 V1279148 P hemerythrin hhe cation binding domain protein COG2461 Cluster_457031 V1279149 ACDA2 map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I acyl-CoA dehydrogenase COG1960 Cluster_457032 V1279150 ARCD S c4-dicarboxylate anaerobic carrier COG1288 Cluster_485150 V1279153 NSPC map00330 E Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) COG0019 Cluster_570237 V1279154 T response regulator COG0745 Cluster_457033 V1279155 S YbbR-like protein COG4856 Cluster_457034 V1279157 S Inherit from NOG: domain protein 0XQ9I Cluster_458997 V1279158 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_473723 V1279159 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_457035 V1279160 PGCA map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_457036 V1279161 RGPD map02010 P ATP-binding protein COG1134 Cluster_705573 V1279162 NRDB map00230,map00240,map00480,map01100,map04115 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_457037 V1279163 P TonB-dependent Receptor Plug 0XNNV Cluster_482834 V1279165 S Sulfide-quinone reductase COG0446 Cluster_457038 V1279166 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_504893 V1279167 T Histidine kinase COG0642 Cluster_512646 V1279168 NUON map00190,map00910,map01100 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) COG1007 Cluster_457039 V1279169 K Bacterial regulatory helix-turn-helix protein, lysR family COG0583 Cluster_461070 V1279172 DCM map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_670171 V1279173 ASNC K regulatory protein, asnc COG1522 Cluster_586235 V1279174 CLVE map02010 S NA 11PT3 Cluster_586236 V1279177 MURE map00300,map00550,map01100 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_502480 V1279178 S integral membrane protein 0ZXN5 Cluster_458998 V1279179 DNAQ map03420,map03430 L Uvrd rep helicase COG2176 Cluster_458999 V1279180 ACRA V Efflux transporter rnd family, mfp subunit 0ZVKK Cluster_579798 V1279181 ALL2459 S ATP GTP Binding Protein 0XQ3U Cluster_459000 V1279182 M domain protein COG4932 Cluster_457040 V1279183 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_741677 V1279184 C Dehydrogenase COG1012 Cluster_459001 V1279185 V type I restriction-modification system COG0732 Cluster_751770 V1279186 S phage terminase large subunit 0ZCYP Cluster_721763 V1279187 S phage portal protein, SPP1 0ZZDC Cluster_457041 V1279188 GLGB map00500,map01100,map01110 G pullulanase, type i COG1523 Cluster_515361 V1279190 map00430,map00620,map00640,map00720,map01100,map01120 Q Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) COG4869 Cluster_526259 V1279191 COABC map00770,map01100 H Phosphopantothenoylcysteine decarboxylase COG0452 Cluster_459002 V1279192 ENTB Q Isochorismatase, hydrolase 11I3F Cluster_629377 V1279196 FLDA map00960 C L-carnitine dehydratase bile acid-inducible protein F COG1804 Cluster_459003 V1279197 E dipeptide-binding protein COG0747 Cluster_459004 V1279198 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_699439 V1279202 PROB map00330,map01100,map01230 E Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) COG0263 Cluster_459007 V1279204 G Major Facilitator superfamily 171RX@proNOG Cluster_738283 V1279205 TAGO M Glycosyl transferase, family 4 COG0472 Cluster_586237 V1279206 LPTB map02010 S ABC transporter COG1137 Cluster_645141 V1279208 S NA 11K4P Cluster_492289 V1279209 FUMC map00020,map00720,map01100,map01110,map01120,map05200,map05211 C fumarate hydratase class II COG0114 Cluster_459009 V1279212 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_607113 V1279213 FRVR K frv operon regulatory protein COG3711 Cluster_459010 V1279214 O Inherit from COG: Mg chelatase subunit ChlI COG0606 Cluster_549222 V1279216 YIEG S Xanthine uracil vitamin C permease COG2252 Cluster_459011 V1279217 S Membrane 11ZHS Cluster_573469 V1279219 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_599891 V1279221 RC1_2786 L transposase COG5433 Cluster_461071 V1279222 CBID map00860,map01100,map02010 H May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) COG1903 Cluster_555002 V1279223 RPLS map03010 J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) COG0335 Cluster_461072 V1279224 V Efflux ABC transporter, permease protein 0XPE8 Cluster_718465 V1279225 HUPA L DNA-binding protein COG0776 Cluster_610766 V1279227 NANM S Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) COG3055 Cluster_459013 V1279228 V restriction enzyme COG1002 Cluster_797267 V1279229 DESR map02020 T response regulator COG2197 Cluster_459014 V1279230 S Pfam:Ribonuclease_BN COG1295 Cluster_637262 V1279232 YKUD M ErfK ybiS ycfS ynhG family protein COG1376 Cluster_497283 V1279236 S ATPase (AAA COG1373 Cluster_461074 V1279237 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_781419 V1279238 INFA J however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) COG0361 Cluster_520606 V1279241 GLPP K glycerol-3-phosphate responsive antiterminator COG1954 Cluster_461076 V1279242 ASPA map00250,map00910,map01100 E Aspartate ammonia-lyase COG1027 Cluster_560970 V1279243 FUCA map00051 G Class II aldolase adducin family protein COG0235 Cluster_785506 V1279246 K transcriptional regulator 11VCW Cluster_797268 V1279247 ARSD P Arsenical resistance operon tranS-acting repressor 11UF3 Cluster_461077 V1279248 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_459015 V1279249 CYSE S -acetyltransferase 11PF0 Cluster_461078 V1279250 YOEA V Mate efflux family protein COG0534 Cluster_461079 V1279252 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_461080 V1279253 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_633199 V1279255 S Membrane COG1811 Cluster_567150 V1279258 M Bacteriophage peptidoglycan hydrolase COG0791 Cluster_546190 V1279259 DNAG map03030 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 Cluster_844395 V1279260 SRTC M (sortase) family COG3764 Cluster_461081 V1279262 MELB G melibiose sodium symporter COG2211 Cluster_459018 V1279263 S NA 11NI8 Cluster_461082 V1279265 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_461084 V1279267 P TonB-dependent Receptor Plug 0XNNV Cluster_515362 V1279269 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_461085 V1279270 GLNQ map02010 E ABC transporter, ATP-binding protein COG1126 Cluster_586238 V1279271 TRMB S Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 Cluster_461086 V1279272 S NA 0YG6V Cluster_461087 V1279273 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_461088 V1279274 V ABC, transporter COG1131 Cluster_461090 V1279276 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_649241 V1279278 DPPC P abc transporter permease protein COG1173 Cluster_880318 V1279279 ISDE map02010 P (ABC) transporter COG0614 Cluster_461092 V1279280 G Major facilitator superfamily MFS_1 COG0477 Cluster_461093 V1279281 M Auxiliary transport protein, membrane fusion protein COG0845 Cluster_461094 V1279282 C FMN-binding domain protein COG3976 Cluster_461095 V1279284 LIN2373 V Abortive infection bacteriophage resistance protein COG4823 Cluster_552111 V1279286 O peptidase COG1026 Cluster_461097 V1279288 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_461098 V1279289 TERL L Terminase, large subunit COG4626 Cluster_555003 V1279290 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_494771 V1279291 PURE map00230,map01100,map01110 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) COG0041 Cluster_471627 V1279292 D Inherit from COG: cobyrinic Acid a,c-diamide synthase COG1192 Cluster_461099 V1279293 G transporter major facilitator family protein 0ZWFP Cluster_461100 V1279294 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_621879 V1279295 RPLN map03010 J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) COG0093 Cluster_576676 V1279296 BL02553 K Transcriptional regulator COG1959 Cluster_463181 V1279297 L integrase family COG4974 Cluster_731705 V1279298 YAZA L domain protein COG2827 Cluster_711845 V1279299 S Membrane COG2966 Cluster_461101 V1279300 MACB map02010 V abc transporter permease protein COG0577 Cluster_463182 V1279302 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_625676 V1279303 C Nitroreductase COG0778 Cluster_461103 V1279304 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_461104 V1279305 RNY S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 Cluster_793300 V1279307 RPLN map03010 J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) COG0093 Cluster_748328 V1279308 RPSQ map03010 J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal COG0186 Cluster_463183 V1279309 S Peptidase m28 COG2234 Cluster_461105 V1279310 NHAC-1 map00680 C Na H antiporter COG1757 Cluster_463184 V1279311 RIHC map00230,map00240,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_657444 V1279312 FSA map00030,map01100,map01110,map01120,map01230 G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) COG0176 Cluster_848282 V1279313 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase COG3959 Cluster_531857 V1279314 GLPB map00564 E anaerobic glycerol-3-phosphate dehydrogenase, subunit B COG3075 Cluster_461106 V1279315 SIGB K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG1191 Cluster_463185 V1279316 S Membrane COG3949 Cluster_461107 V1279317 T transcriptional activator COG3899 Cluster_589519 V1279318 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_461108 V1279319 S Organic solvent tolerance protein 0XQ3B Cluster_463186 V1279322 PPAC map00190 C Manganese-dependent inorganic pyrophosphatase COG1227 Cluster_534648 V1279324 S NA 101UU Cluster_461109 V1279325 S NA 11F81 Cluster_463187 V1279326 YYBT T domain protein COG3887 Cluster_461110 V1279327 YLMH J s4 domain protein COG2302 Cluster_463188 V1279328 L CRISPR-associated protein, Csn1 family COG3513 Cluster_463190 V1279334 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_463191 V1279336 V Inherit from COG: Type I site-specific deoxyribonuclease COG0610 Cluster_463192 V1279338 ATP2C1 P p-type ATPase COG0474 Cluster_805405 V1279339 NAGB map00520,map01100,map01110 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COG0363 Cluster_770213 V1279340 NANE map00520 G Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) COG3010 Cluster_463193 V1279341 NAGB map00520,map01100,map01110 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COG0363 Cluster_549223 V1279342 L site-specific recombinase, phage integrase family 0ZF8H Cluster_461112 V1279343 U, W Pfam:YadA COG5295 Cluster_670172 V1279344 S phage plasmid primase, p4 family COG3378 Cluster_801243 V1279345 L CHC2 zinc finger domain protein 11GE1 Cluster_502481 V1279346 K Transcriptional regulator, TetR family 0YTCU Cluster_463194 V1279348 NARB map00630,map00680,map00910,map01100,map01120 C Molydopterin dinucleotide binding domain COG0243 Cluster_463195 V1279350 NHAD P Na H antiporter COG1055 Cluster_621880 V1279351 GLDE P CBS domain containing protein COG1253 Cluster_607114 V1279352 RPSM map03010 J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits COG0099 Cluster_884443 V1279353 PTBA map00010,map00500,map00520,map02060 G Pts system COG2190 Cluster_579799 V1279354 NAGA map00520,map01110 G GlcNAc 6-P deacetylase COG1820 Cluster_531859 V1279356 SUA5 J sua5 ycio yrdc ywlc family protein COG0009 Cluster_518031 V1279358 SARE_3718 S Terminase 11NCI Cluster_463197 V1279359 ATPA map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_665860 V1279360 GLPF G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) COG0580 Cluster_482835 V1279361 PFLX S radical SAM domain protein COG1313 Cluster_463198 V1279362 SP_1997 S COF family COG4696 Cluster_499948 V1279363 TRKH P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) COG0168 Cluster_463199 V1279364 PBP1A map00310,map00550,map00780,map01100 M penicillin-binding protein COG5009 Cluster_463200 V1279365 GLNE O, T Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) COG1391 Cluster_463201 V1279367 ETFA map00910 C Electron transfer flavoprotein COG2025 Cluster_543261 V1279369 K repB Plasmid Partition COG1475 Cluster_699440 V1279371 S NA 0YJH0 Cluster_872168 V1279372 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_592922 V1279373 YHBJ S Displays ATPase and GTPase activities (By similarity) COG1660 Cluster_463202 V1279374 PCKA map00010,map00020,map00620,map00710,map01100,map01110,map01120 C Phosphoenolpyruvate Carboxylase COG1866 Cluster_785507 V1279375 XC_0680 L transposase COG2963 Cluster_467355 V1279376 PPK map00190,map03018 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) COG0855 Cluster_618236 V1279378 J RNA methyltransferase COG2265 Cluster_463203 V1279379 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_852076 V1279380 NUOH map00190,map00910,map01100 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) COG1005 Cluster_633200 V1279381 NUOI map00190,map00910,map01100 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) COG1143 Cluster_537536 V1279382 DXS map00730,map00900,map01100,map01110 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) COG1154 Cluster_463204 V1279383 M domain protein COG4932 Cluster_463205 V1279385 YHAN S domain protein COG4717 Cluster_552112 V1279386 S NA 0YDPS Cluster_832601 V1279390 K RNA Polymerase 12C9K Cluster_465269 V1279392 S Phage tail tape measure protein, TP901 family 10QPB Cluster_884445 V1279393 Q Methyltransferase COG0500 Cluster_751771 V1279394 S s23 ribosomal protein 121RZ Cluster_546191 V1279396 PDXS map00750 H Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) COG0214 Cluster_463206 V1279398 S c4-dicarboxylate anaerobic carrier COG1288 Cluster_487442 V1279399 M (sortase) family COG3764 Cluster_592923 V1279401 SRTC M (sortase) family COG3764 Cluster_463207 V1279404 EXSA V abc transporter COG1132 Cluster_465270 V1279405 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_692421 V1279407 FIS K Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) COG2901 Cluster_705574 V1279408 RPSE map03010 J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) COG0098 Cluster_770215 V1279409 RPLO map03010 J Binds to the 23S rRNA (By similarity) COG0200 Cluster_463209 V1279411 M glycosyltransferase group 1 family protein COG0438 Cluster_546192 V1279413 YFCC S c4-dicarboxylate anaerobic carrier COG1288 Cluster_465271 V1279415 FRUA map00051,map01100,map02060 G PTS System COG1762 Cluster_482836 V1279416 map00627,map00790,map01100,map01120,map02020 Q alkaline phosphatase 0XNQ8 Cluster_465272 V1279417 ILVA map00260,map00290,map01100,map01110,map01230 E Threonine dehydratase COG1171 Cluster_515364 V1279418 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_463210 V1279420 GLNA map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG3968 Cluster_463211 V1279421 S Abortive phage resistance protein 11RQ0 Cluster_734957 V1279422 OPPD map02010 E, P oligopeptide ABC transporter, ATP-binding protein COG0444 Cluster_728441 V1279423 OPPF map02010 E (ABC) transporter COG4608 Cluster_463212 V1279424 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_465273 V1279425 S Pfam:Bug COG3181 Cluster_465274 V1279427 BDHA map00051,map00363,map00591,map00625,map00650,map01100,map01120 C alcohol dehydrogenase COG1979 Cluster_465276 V1279431 DPNA L helicase COG4646 Cluster_563949 V1279433 BSEL_0787 S Phage terminase small subunit COG3747 Cluster_576677 V1279434 S Pfam:DUF901 11XWA Cluster_557921 V1279435 S NA 0Z7KY Cluster_473724 V1279438 map00053,map01100,map01120,map02060 G IIa component COG1762 Cluster_531860 V1279439 S NA 11THP Cluster_465277 V1279440 M glycosyltransferase group 2 family protein COG0463 Cluster_465278 V1279441 S AAA-ATPase 0XQ4X Cluster_465279 V1279442 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_773916 V1279445 YJEE S protein family UPF0079, ATPase COG0802 Cluster_504895 V1279448 PRC M Peptidase, S41 family COG0793 Cluster_762554 V1279449 PEPC E aminopeptidase c COG3579 Cluster_502482 V1279450 K, L domain protein COG0553 Cluster_465281 V1279451 L Replication initiation factor COG2946 Cluster_465282 V1279452 map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_465284 V1279456 YQEV J MiaB-like tRNA modifying enzyme COG0621 Cluster_534649 V1279457 BAPKO_0207 P CBS domain protein COG1253 Cluster_465285 V1279458 MUTG map02010 S ABC transporter 11QI3 Cluster_512647 V1279459 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_614487 V1279460 ASCB map00010,map00460,map00500,map00940,map01100,map01110 G 6-phospho-beta-glucosidase COG2723 Cluster_629378 V1279462 S Sigma-70, region 4 11V6D Cluster_467357 V1279463 map02010 P ABC transporter COG1122 Cluster_465286 V1279464 S phage portal protein HK97 family COG4695 Cluster_576678 V1279465 ETFB map00910 C Electron transfer flavoprotein COG2086 Cluster_805406 V1279467 CSPH K Cold shock-like protein 17M30@proNOG Cluster_465287 V1279468 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_467358 V1279469 YADS S Membrane COG2860 Cluster_465288 V1279470 WS0013 S membrAne 0XPGN Cluster_467359 V1279471 K RNA Polymerase COG0086 Cluster_465289 V1279472 LYSM M LysM domain M23 M37 peptidase domain protein COG0739 Cluster_465290 V1279473 DGT map00230 F deoxyguanosinetriphosphate triphosphohydrolase-like protein COG0232 Cluster_467360 V1279474 map00627,map00790,map01100,map01120,map02020 Q alkaline phosphatase 0XNQ8 Cluster_467361 V1279477 DPPC P ABC transporter permease protein COG1173 Cluster_773917 V1279479 S NA 0XWFB Cluster_809432 V1279480 S Transporter, auxin efflux carrier (AEC) family protein COG0679 Cluster_555004 V1279481 XPT map00230,map01100,map01110 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) COG0503 Cluster_586239 V1279482 DEOA map00240,map00983,map01100,map05219 F The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) COG0213 Cluster_502483 V1279483 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_467362 V1279484 DNAJ O DnaJ domain protein COG0484 Cluster_465291 V1279485 S NA 0YK1E Cluster_467363 V1279486 OPPA map02010 E Extracellular solute-binding protein, family 5 COG4166 Cluster_467364 V1279487 PYC map00020,map00620,map00720,map01100,map01120,map01230 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) COG1038 Cluster_526261 V1279490 S TraX protein 11N9P Cluster_570238 V1279492 map02010 P Periplasmic binding protein COG0614 Cluster_465292 V1279494 FUCO map00620,map00630,map01120 C alcohol dehydrogenase COG1454 Cluster_649242 V1279495 map00627,map00740,map01120,map05152 S Phosphatase COG1409 Cluster_467366 V1279496 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_725114 V1279497 S NA 11G8Y Cluster_467367 V1279498 OCAR_5891 map00020,map00720,map01100,map01110,map01120,map05200,map05211 P iron permease COG0672 Cluster_738284 V1279499 S Protein of unknown function (DUF2795) 11U61 Cluster_467368 V1279501 P tonB-dependent Receptor COG4771 Cluster_467370 V1279503 FEPE P Ferric enterobactin transport protein COG3765 Cluster_467371 V1279504 TYPA T gtp-binding protein typa COG1217 Cluster_467372 V1279505 S UPF0597 protein COG3681 Cluster_467373 V1279508 OCAR_6158 L Terminase, large subunit COG4626 Cluster_596395 V1279510 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG2812 Cluster_467374 V1279511 THYA map00240,map00670,map01100 F Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) COG0207 Cluster_467375 V1279512 AZL_008530 O AAA ATPase central COG0464 Cluster_494772 V1279514 YQJG O Glutathione S-transferase COG0435 Cluster_467376 V1279515 S Phage infection protein COG1511 Cluster_494773 V1279516 SERP0565 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_467377 V1279517 O Peptidyl-prolyl cis-trans isomerase 0XT59 Cluster_793303 V1279518 RPMC map03010 J 50s ribosomal protein l29 COG0255 Cluster_467378 V1279519 S (LipO)protein 1C848@synNOG Cluster_744983 V1279520 HIT map00230,map00240 F, G histidine triad (hIT) protein COG0537 Cluster_494774 V1279521 map02010 E extracellular solute-binding protein 16RK7@proNOG Cluster_625677 V1279527 YTFP S hi0933 family COG2081 Cluster_507468 V1279528 S cyclase, family COG1878 Cluster_467379 V1279529 PARB K parb-like partition protein COG1475 Cluster_467380 V1279530 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_674561 V1279531 SPOVG M Could be involved in septation (By similarity) COG2088 Cluster_469476 V1279532 XTH map03410 L Exodeoxyribonuclease III COG0708 Cluster_629379 V1279537 ARCC map00230,map00330,map00910,map01120 E carbamate kinase COG0549 Cluster_781422 V1279538 YHEU S UPF0270 protein COG3089 Cluster_469478 V1279539 GLNN map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG3968 Cluster_596396 V1279540 FTSY map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 Cluster_467381 V1279542 L NA 0YD01 Cluster_469479 V1279543 MALY map00270,map00450,map00920,map01100,map01110,map01230 E Aminotransferase class I and II COG1168 Cluster_467382 V1279545 PROTEASE map05120 O Peptidase U32 COG0826 Cluster_618238 V1279546 E Dipeptidase COG4690 Cluster_469480 V1279550 SITB map02010,map02020 P (ABC) transporter COG1121 Cluster_469481 V1279551 GATA map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120,map04723 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) COG0154 Cluster_766509 V1279554 ARGJ map00330,map01100,map01110,map01210,map01230 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) COG1364 Cluster_797270 V1279555 ARGB map00330,map01100,map01110,map01210,map01230 E nag kinase COG0548 Cluster_467384 V1279556 U type ii secretion system 11ZC3 Cluster_469483 V1279557 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_485151 V1279559 SOJ D Chromosome Partitioning Protein COG1192 Cluster_657445 V1279560 S copper amine 121X1 Cluster_469484 V1279561 L DNA mismatch repair protein COG0249 Cluster_487443 V1279563 MALK map02010 G Abc transporter COG3839 Cluster_540327 V1279565 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_469486 V1279567 V abc transporter permease protein COG0577 Cluster_469487 V1279568 S NA 0XRRN Cluster_467385 V1279570 S Inherit from NOG: domain protein 0XQ9I Cluster_469489 V1279571 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_467386 V1279572 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_469490 V1279573 FTSI map00550,map01100 M penicillin-binding protein COG0768 Cluster_621882 V1279574 K Transcriptional regulator, TetR family 11JD6 Cluster_469491 V1279577 RFBD map00521,map00523,map01100,map01110 M Dtdp-4-dehydrorhamnose reductase COG1091 Cluster_473725 V1279579 NMB1124 S (LipO)protein COG4380 Cluster_543262 V1279580 AZLC E branched-chain amino acid COG1296 Cluster_469492 V1279581 DUSB J Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_469493 V1279582 M Cell wall binding repeat 2-containing protein COG2247 Cluster_469494 V1279583 E HAD-superfamily subfamily IB hydrolase COG0560 Cluster_805407 V1279585 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_801244 V1279586 DMPI map00362,map00621,map00622,map01100,map01120 S 4-oxalocrotonate tautomerase COG1942 Cluster_494775 V1279588 YMDB S appr-1-p processing domain protein COG2110 Cluster_469496 V1279592 CPHY_1803 L transposase 0XQMH Cluster_469497 V1279593 V abc transporter permease protein 0ZW5X Cluster_469498 V1279594 S plasmid recombination enzyme 1004W Cluster_692422 V1279595 HGDB map00362,map00363,map00626,map00650,map00903,map01100,map01110,map01120 E dehydratase COG1775 Cluster_793304 V1279596 HGDA map00362,map01100,map01120,map01220 E dehydratase COG1775 Cluster_475894 V1279597 MT1102 S membrane COG4760 Cluster_731706 V1279600 S NA 127XC Cluster_705575 V1279602 S Pfam:DUF124 COG2013 Cluster_469500 V1279605 S NA 0YKNH Cluster_471629 V1279606 PGM map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_471630 V1279607 CLPB O ATP-dependent chaperone COG0542 Cluster_852078 V1279610 BMUL_5873 S gtp-binding protein COG1306 Cluster_471631 V1279611 MTRC V efflux transporter, rnd family, mfp subunit 0XNVN Cluster_482837 V1279612 V ABC transporter COG1132 Cluster_661648 V1279613 K Transcriptional regulator, luxr family COG2197 Cluster_471632 V1279614 E ABC transporter COG0747 Cluster_718466 V1279617 L Addiction module antitoxin, RelB DinJ family COG3077 Cluster_471633 V1279619 M efflux transporter, outer membrane factor lipoprotein, NodT family COG1538 Cluster_531861 V1279620 C Hydrogenase large subunit domain protein COG4624 Cluster_475895 V1279621 S DNA-binding helix-turn-helix protein 0ZJRR Cluster_469502 V1279622 GGT map00430,map00460,map00480,map00590,map01100 E gamma-glutamyltransferase COG0405 Cluster_478105 V1279623 L resolvase COG1961 Cluster_610767 V1279624 RPSF map03010 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 Cluster_876276 V1279625 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_579801 V1279626 S NA 0ZTS3 Cluster_469503 V1279627 BL01497 Q methyltransferase COG0500 Cluster_576679 V1279629 RECX S Modulates RecA activity (By similarity) COG2137 Cluster_471634 V1279631 T two-component system sensor histidine kinase response regulator, hybrid COG3706 Cluster_855855 V1279633 RUBR C rubredoxin COG1773 Cluster_471635 V1279635 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_471636 V1279638 S NA 11GMQ Cluster_471637 V1279640 M Polysaccharide Biosynthesis Protein 0XP95 Cluster_469504 V1279641 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_603504 V1279642 GTF2 O A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1 (By similarity) 0XQZU Cluster_471638 V1279644 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_567151 V1279646 S Conserved Protein 11U7C Cluster_482838 V1279647 NTPC map00190,map00680,map01100 C ATP synthase subunit C COG1527 Cluster_523347 V1279648 map02010 V ABC-2 type transporter 11HGA Cluster_471639 V1279650 PGCA map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_725115 V1279653 RPSO map03010 J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) COG0184 Cluster_471640 V1279654 S NA 0YB2E Cluster_515365 V1279655 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_546193 V1279656 SCLAV_2230 V ABC, transporter COG0577 Cluster_469505 V1279658 DNAK map03018,map05152 O Acts as a chaperone (By similarity) COG0443 Cluster_665861 V1279659 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_633202 V1279661 CLOSA_1745 L transposase COG2963 Cluster_471642 V1279662 YDCP map05120 O Peptidase, U32 family COG0826 Cluster_471643 V1279663 PSD map00564,map01100 I Phosphatidylserine decarboxylase proenzyme COG0688 Cluster_471646 V1279667 HFLX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COG2262 Cluster_471647 V1279668 COMEC S DNA internalization-related competence protein ComEC Rec2 COG2333 Cluster_489792 V1279669 V abc transporter permease protein 0XQE2 Cluster_471649 V1279671 S NA 0Y8QF Cluster_471650 V1279672 YBIW map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_471651 V1279673 CTPC map00190 P heavy metal translocating P-type ATPase COG2217 Cluster_762556 V1279674 S NA 0ZHU9 Cluster_777606 V1279675 WECD map00350,map00362,map00627,map00642,map00903,map01120 S -acetyltransferase 11PF0 Cluster_864210 V1279676 S NA 0ZT7Y Cluster_515366 V1279677 O UPF0251 protein COG1342 Cluster_471652 V1279678 GLK map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G ROK family COG1940 Cluster_637263 V1279679 FSAB map00030,map01100,map01110,map01120,map01230 G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) COG0176 Cluster_473726 V1279680 V ABC transporter, ATP-binding protein COG1132 Cluster_596398 V1279683 PFOR S Membrane COG3641 Cluster_537537 V1279685 E Glycosyl Hydrolase Family 88 COG4289 Cluster_471653 V1279686 M Capsular exopolysaccharide family COG0489 Cluster_531862 V1279689 K cell envelope-related transcriptional attenuator COG1316 Cluster_471654 V1279692 ZUPT P Mediates zinc uptake. May also transport other divalent cations (By similarity) COG0428 Cluster_471655 V1279693 AROA map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate synthase COG0128 Cluster_610768 V1279694 SP_1851 map00360 Q Thioesterase COG2050 Cluster_534650 V1279695 S NA 11NI8 Cluster_494776 V1279697 M carboxy-peptidase COG1876 Cluster_471656 V1279698 ERIC P Chloride channel COG0038 Cluster_473727 V1279699 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_473728 V1279700 map02010 G ABC transporter COG1653 Cluster_633203 V1279702 S Hypothetical bacterial integral membrane protein (Trep_Strep) 11MJD Cluster_497285 V1279704 PPK map00190,map03018 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) COG0855 Cluster_817158 V1279705 SMU_1348C V ABC transporter, ATP-binding protein COG1136 Cluster_674562 V1279706 V abc transporter permease protein COG0577 Cluster_560971 V1279707 MREB D Rod shape-determining protein mreb COG1077 Cluster_855857 V1279708 BCD map00071,map00280,map00281,map00650,map01100,map01110 I acyl-CoA dehydrogenase COG1960 Cluster_653325 V1279709 ETFB map00910 C Electron transfer flavoprotein COG2086 Cluster_540328 V1279711 VRAR map02020 T response regulator COG2197 Cluster_523349 V1279712 S Copper amine oxidase domain-containing protein 0XT7E Cluster_507469 V1279713 TDK map00240,map00983,map01100 F thymidine kinase COG1435 Cluster_471658 V1279715 N Cell surface protein 1CAVF@tenNOG Cluster_683570 V1279716 PFK map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G K00850 6-phosphofructokinase 1 EC 2.7.1.11 COG0205 Cluster_473729 V1279717 S s-layer domain-containing protein 11ZJU Cluster_563950 V1279718 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_573470 V1279719 SCLAV_2568 J endoribonuclease L-psp COG0251 Cluster_537538 V1279721 CAT map00281,map00620,map00626,map01110,map01120 C Transferase COG0427 Cluster_515367 V1279722 MT3095 S Methionine synthase vitamin-b12 independent 0XYJG Cluster_471659 V1279723 PRC M Peptidase, S41 family COG0793 Cluster_711846 V1279724 BMUL_1547 K Transcriptional regulator 0XUB6 Cluster_504896 V1279725 RLUC J pseudouridine synthase COG0564 Cluster_473730 V1279727 PEPF E Oligoendopeptidase f COG1164 Cluster_473731 V1279728 S tigr02206 127PX Cluster_485152 V1279729 ALGI M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_529017 V1279731 V ABC transporter COG1132 Cluster_473732 V1279733 HSDS V Restriction modification system DNA (Specificity COG0732 Cluster_473733 V1279734 RIBU S Membrane COG3601 Cluster_473734 V1279735 S Membrane 0XP2G Cluster_473735 V1279736 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_674563 V1279738 S NA 12AV7 Cluster_473736 V1279739 YAJR G Major Facilitator COG0477 Cluster_473737 V1279740 MALX map02010 G extracellular solute-binding protein family 1 COG2182 Cluster_473738 V1279743 LEPB map03060 U Signal peptidase i COG0681 Cluster_688001 V1279745 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_473739 V1279746 HPPA map00190 C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for COG3808 Cluster_473740 V1279747 SUA J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0009 Cluster_473741 V1279748 map02010 E, P ABC transporter COG4608 Cluster_473742 V1279749 MRDA map00550 M Penicillin-binding protein 2 COG0768 Cluster_579802 V1279757 YLBM S UPF0348 protein COG1323 Cluster_475896 V1279758 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_475897 V1279759 G Domain-Containing protein 11Q0T Cluster_475898 V1279760 S NA 0ZZGV Cluster_549224 V1279761 NRDG O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) COG0602 Cluster_579803 V1279764 TATD L Hydrolase, tatD family COG0084 Cluster_473744 V1279766 RPLY map03010 J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) COG1825 Cluster_512648 V1279767 S Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) 0XTXX Cluster_520607 V1279768 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_708650 V1279769 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_475900 V1279770 UGD map00040,map00053,map00500,map00520,map01100,map01110 M UDP-glucose 6-dehydrogenase COG1004 Cluster_502484 V1279771 S NA 11PZU Cluster_529019 V1279772 L Recombinase COG1961 Cluster_475901 V1279773 ASPA map00250,map00910,map01100 E Aspartate ammonia-lyase COG1027 Cluster_475902 V1279774 S NA 11AFT Cluster_549225 V1279775 FTNA map00860 P ferritin COG1528 Cluster_475903 V1279778 S NA 122AV Cluster_473745 V1279780 N Cell surface protein 1CAVF@tenNOG Cluster_475904 V1279781 T response regulator COG0745 Cluster_475905 V1279782 DMSC S dmso reductase anchor subunit COG3302 Cluster_475906 V1279783 INT S 'Phage' integrase family 0YKE0 Cluster_475907 V1279786 HSDM V type I restriction-modification system COG0286 Cluster_475908 V1279787 GLTD map00450 E Selenate reductase, YgfK COG0493 Cluster_475909 V1279788 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_515368 V1279790 map02010 P Periplasmic binding protein COG0614 Cluster_832603 V1279791 ATPG map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) COG0224 Cluster_683571 V1279792 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_475910 V1279793 U, W surface protein COG5295 Cluster_473746 V1279794 map05100 S repeat protein 11TEE Cluster_840360 V1279795 S Pfam:DUF567 COG4894 Cluster_475911 V1279796 L helicase domain protein COG0553 Cluster_475912 V1279798 S Clostripain family 0YH96 Cluster_475913 V1279800 YKOD map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_695094 V1002601 BOPA E Extracellular solute-binding protein, family 5 COG0747 Cluster_324189 V1002602 XFP map00030,map00680,map00710,map01100,map01120 G Phosphoketolase COG3957 Cluster_695095 V1002603 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_585165 V1002604 RECR map03440 L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) COG0353 Cluster_403142 V1002606 MALQ map00500,map01100 G 4-alpha-glucanotransferase (EC 2.4.1.25) COG1640 Cluster_460411 V1002607 PYRR map00240,map01100 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) COG2065 Cluster_327250 V1002608 DESK map02020 T Histidine kinase COG4585 Cluster_325696 V1002609 PKNA T serine threonine protein kinase COG0515 Cluster_468844 V1002610 MTA K Transcriptional regulator COG0789 Cluster_337739 V1002611 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_327251 V1002612 YJCE P Na H antiporter COG0025 Cluster_360048 V1002613 YBHL S Membrane COG0670 Cluster_328806 V1002614 CSHB map03018 L ATP-dependent RNA helicase COG0513 Cluster_525347 V1002615 YKNZ V ABC transporter, permease COG0577 Cluster_328807 V1002616 MNAA map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_328808 V1002617 HYL map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 S K01197 hyaluronoglucosaminidase EC 3.2.1.35 0XPBQ Cluster_328809 V1002618 S NA 0YA5W Cluster_426619 V1002619 LPCA M Glycosyl transferase family 8 COG1442 Cluster_812151 V1002620 S Domain of unknown function (DUF1827) 0XV2U Cluster_486734 V1002621 MUTT L Nudix family COG0494 Cluster_426620 V1002622 K function transcriptional attenuator common domain protein COG1316 Cluster_343792 V1002624 BET L Phage recombination protein Bet 11G2M Cluster_466666 V1002625 map00230,map00760,map01100 F Nudix Hydrolase COG1051 Cluster_769114 V1002626 PNUC H Nicotinamide Mononucleotide Transporter COG3201 Cluster_330182 V1002627 FEOB P Ferrous iron transport protein b COG0370 Cluster_331741 V1002628 YYCH S YycH protein COG4863 Cluster_331742 V1002629 GAP map00010,map01100,map01110,map01120,map01230,map04066,map05010 G Glyceraldehyde-3-phosphate dehydrogenase COG0057 Cluster_442511 V1002630 S NA 0YENE Cluster_331743 V1002631 PBP1B map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_331744 V1002633 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_351716 V1002634 PURB map00230,map00250,map01100,map01110 F adenylosuccinate lyase COG0015 Cluster_361614 V1002636 SASC S surface protein 11FPX Cluster_643821 V1002638 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_677539 V1002639 YITL S S1 RNA binding domain protein COG2996 Cluster_333221 V1002640 AHPF O Alkyl hydroperoxide reductase COG3634 Cluster_337740 V1002641 PBUG S Xanthine uracil vitamin C permease COG2252 Cluster_562876 V1002642 TAUB P ATP-binding protein COG1116 Cluster_899484 V1002643 RPSD map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) COG0522 Cluster_334686 V1002644 YHGE S domain protein COG1511 Cluster_410229 V1002645 RECQ map03018 L ATP-dependent DNA helicase COG0514 Cluster_333222 V1002646 PEPC E aminopeptidase c COG3579 Cluster_399607 V1002647 MSRA O reductase COG0229 Cluster_363203 V1002649 YITU S hydrolase COG0561 Cluster_336243 V1002650 PARB K parb-like partition protein COG1475 Cluster_334688 V1002651 M YD repeat protein COG3209 Cluster_385456 V1002652 PURA map00230,map00250,map01100 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis COG0104 Cluster_533714 V1002653 S Glucan-binding protein C 0ZJN4 Cluster_616930 V1002654 SP_1682 G ABC transporter permease COG1175 Cluster_602265 V1002655 SP_1681 G ABC transporter (Permease COG0395 Cluster_450527 V1002656 PI346 L dna replication protein COG1484 Cluster_336244 V1002657 MVAS map00072,map00280,map00650,map00900,map01100,map01110 I Hydroxymethylglutaryl-CoA synthase COG3425 Cluster_452479 V1002658 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_336245 V1002659 NIRK map00910,map01120 Q nitrite reductase COG2132 Cluster_875003 V1002660 MT0828 S NA 11U2D Cluster_475201 V1002662 LYSA map00260,map00270,map00300,map01100,map01110,map01120,map01230 E diaminopimelate decarboxylase COG0019 Cluster_835224 V1002663 YNEF S UPF0154 protein COG3763 Cluster_337741 V1002664 LACZ map00052,map00511,map00600,map01100 G beta-galactosidase COG3250 Cluster_369953 V1002665 ARCB map00330,map01100,map01110,map01230 E ornithine carbamoyltransferase COG0078 Cluster_373222 V1002666 GDHA map00250,map00330,map00910,map01100 E Glutamate dehydrogenase COG0334 Cluster_364908 V1002667 GLNQ map02010 E abc transporter COG1126 Cluster_337742 V1002668 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_390777 V1002669 ABPB E Dipeptidase COG4690 Cluster_337744 V1002672 PURL F phosphoribosylformylglycinamidine synthase COG0047 Cluster_578694 V1002673 PURK map00230,map01100,map01110 F phosphoribosylaminoimidazole carboxylase atpase subunit COG0026 Cluster_337745 V1002674 TIG O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COG0544 Cluster_354994 V1002675 M Inherit from COG: n-acetylmuramoyl-l-alanine amidase COG0860 Cluster_660232 V1002676 GLGA map00500,map01100,map01110,map04973 G Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) COG0297 Cluster_444511 V1002678 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0516 Cluster_337746 V1002679 RSEP map04112 M Membrane-associated zinc metalloprotease COG0750 Cluster_522464 V1002681 S NA 1021W Cluster_569193 V1002682 MERR K Transcriptional regulator COG0789 Cluster_408420 V1002683 COTA Q Multicopper oxidase COG2132 Cluster_340715 V1002684 GLTT map02020 C -dicarboxylate symporter COG1301 Cluster_419234 V1002686 S domain protein 0Y1ZG Cluster_351717 V1002687 F Endonuclease Exonuclease phosphatase COG2374 Cluster_340716 V1002688 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_340717 V1002689 SP_0498 map00511 G endo-beta-N-acetylglucosaminidase COG4724 Cluster_504138 V1002691 ATPG map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) COG0224 Cluster_843111 V1002692 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_342181 V1002694 BL01373 L Integrase COG0582 Cluster_560001 V1002695 NANH map00300,map00520,map01100,map01110,map01120,map01230 E, M N-acetylneuraminate lyase COG0329 Cluster_686450 V1002696 GLCK map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G, K ROK family COG1940 Cluster_340718 V1002697 GLDA map00561,map01100 C glycerol dehydrogenase COG0371 Cluster_342182 V1002699 HUTH map00340,map01100 E Histidine ammonia-lyase COG2986 Cluster_342183 V1002700 TRKH P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) COG0168 Cluster_450528 V1002706 FLD C Flavodoxin COG0716 Cluster_342184 V1002707 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_440485 V1002708 YWFO S Phosphohydrolase COG1078 Cluster_343793 V1002710 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_342185 V1002711 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0516 Cluster_376624 V1002712 RNY S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 Cluster_686451 V1002713 BUDA map00650,map00660 Q Alpha-acetolactate decarboxylase COG3527 Cluster_647841 V1002714 SP_1504 S Tetratricopeptide repeat protein COG0457 Cluster_374926 V1002715 PHOU P Plays a role in the regulation of phosphate uptake COG0704 Cluster_345390 V1002716 ESSC D ftsk spoIIIe COG1674 Cluster_380134 V1002717 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_371597 V1002718 YLOV S dak2 domain fusion protein ylov COG1461 Cluster_374927 V1002719 ASPC map00250,map00290,map01100,map01110,map01210,map01230 E Aminotransferase COG0436 Cluster_345391 V1002720 CORA P transporter COG0598 Cluster_399608 V1002721 S NA 0Y46N Cluster_677540 V1002723 NTPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_346939 V1002724 CODA map00240,map00330,map00791,map01100,map01120 F cytosine deaminase COG0402 Cluster_364909 V1002726 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_345392 V1002727 DACA map00550,map01100 M carboxypeptidase COG1686 Cluster_460412 V1002728 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_595177 V1002729 RPLN map03010 J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) COG0093 Cluster_499142 V1002730 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_381919 V1002731 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_399609 V1002733 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_635839 V1002734 map02020 T Histidine kinase COG4585 Cluster_396176 V1002735 METQ map02010 P (Lipo)protein COG1464 Cluster_539473 V1002736 TAG map03410 L Dna-3-methyladenine glycosylase i COG2818 Cluster_348612 V1002737 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_350185 V1002738 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_750669 V1002739 HSLO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) COG1281 Cluster_562877 V1002740 DUSB J Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_489012 V1002742 map02010,map02020 P (ABC) transporter COG1121 Cluster_374928 V1002743 S Filamentation induced by cAMP protein fic COG3177 Cluster_350186 V1002744 NSS S galactofuranosyltransferase 11KQ1 Cluster_350187 V1002745 MEPA V Mate efflux family protein COG0534 Cluster_350188 V1002746 HRCA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) COG1420 Cluster_350189 V1002747 AMSD map00051 M Glycosyltransferase COG0438 Cluster_350190 V1002748 GLGC map00500,map00520,map01100,map01110 G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) COG0448 Cluster_456452 V1002749 SP_0010 map00311,map00312,map01110,map02020 V Beta-lactamase COG2367 Cluster_468845 V1002751 YCCU S CoA-binding domain protein COG1832 Cluster_496492 V1002753 WCFS map00051 M transferase COG2148 Cluster_351718 V1002754 ZNTA P copper-exporting ATPase COG2217 Cluster_351719 V1002755 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_351720 V1002756 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Involved in acetate metabolism (By similarity) COG0857 Cluster_351721 V1002757 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_360049 V1002758 LACC map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G tagatose-6-phosphate kinase COG1105 Cluster_635840 V1002759 RNPA J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) COG0594 Cluster_847103 V1002760 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (alpha subunit) COG0587 Cluster_353408 V1002761 NHAP P Na H antiporter COG0025 Cluster_353409 V1002762 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_397922 V1002763 LGAS_0583 S Replication Protein 0YVZX Cluster_351722 V1002764 M Minor structural protein 0XPF3 Cluster_496493 V1002765 CBPC M choline binding protein COG5263 Cluster_554070 V1002766 SP_1634 S Protein of unknown function (DUF2974) 0XSVF Cluster_353410 V1002767 YPDC S Conserved Protein COG3538 Cluster_376625 V1002768 YKNX M Efflux transporter RND family MFP subunit COG0845 Cluster_353411 V1002769 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0470 Cluster_473073 V1002770 SCLAV_2338 K MarR family Transcriptional regulator COG1846 Cluster_354995 V1002772 PACL P cation-transporting atpase COG0474 Cluster_354996 V1002773 TILS D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) COG0037 Cluster_353412 V1002774 GALM map00010,map01110,map01120 G converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) COG2017 Cluster_412022 V1002775 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_354997 V1002776 PTSG map00010,map00500,map00520,map02060 G PTS System COG2190 Cluster_354998 V1002777 METE map00270,map00450,map01100,map01110,map01230 E Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) COG0620 Cluster_371598 V1002778 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_525348 V1002779 TRML map04122 J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) COG0219 Cluster_720722 V1002780 PURA map00230,map00250,map01100 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis COG0104 Cluster_356700 V1002782 RAGF M Glycosyl transferase (Group 1 COG0438 Cluster_368279 V1002783 SUCD map00020,map00640,map00660,map00720,map01100,map01110,map01120 C Succinyl-CoA ligase ADP-forming subunit alpha COG0074 Cluster_354999 V1002784 SRLM K sorbitol operon transcription regulator COG3711 Cluster_491543 V1002786 GND map00030,map00480,map01100,map01110,map01120 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) COG0362 Cluster_381920 V1002788 ALD map00250,map00430,map01100 E alanine dehydrogenase COG0686 Cluster_356701 V1002789 BGAA map00040,map00052,map00500,map00511,map00531,map00600,map00860,map00944,map00983,map01100,map04142 G beta-galactosidase COG3250 Cluster_356702 V1002790 S membrane 11JQ4 Cluster_912172 V1002791 S NA 11E53 Cluster_381921 V1002792 SP_1529 M Polysaccharide Biosynthesis Protein COG2244 Cluster_356703 V1002793 SHC P drug resistance transporter, EmrB QacA subfamily 0XNN3 Cluster_358410 V1002794 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_356704 V1002797 MURM map00550,map01100 V Catalyzes the incorporation of amino acid(s) into the interchain peptide bridge of peptidoglycan, using aminoacyl-tRNA as amino acid donor (By similarity) COG2348 Cluster_358411 V1002799 RECG map03440 L ATP-dependent DNA helicase recG COG1200 Cluster_533784 V1027802 TRAA L TrwC relaxase COG0507 Cluster_531018 V1027807 PMT M glycosyl transferase, family 39 COG1928 Cluster_533787 V1027808 AROA map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate synthase COG0128 Cluster_533788 V1027809 ICD map00020,map00480,map00720,map01100,map01110,map01120,map01210,map01230,map04146 C Isocitrate dehydrogenase COG2838 Cluster_531019 V1027810 map02010 E extracellular ligand-binding receptor COG0683 Cluster_533789 V1027812 HUTU map00340,map01100 E Urocanate hydratase COG2987 Cluster_569277 V1027813 KPST map02010 G, M ATP-binding protein COG1134 Cluster_531020 V1027814 VGRG5 M Rhs element vgr protein COG3501 Cluster_572469 V1027823 PQIB S Mammalian cell entry related domain protein COG3008 Cluster_533790 V1027824 GLTS E Sodium Glutamate Symporter COG0786 Cluster_533791 V1027825 ACTP P p-type atpase COG2217 Cluster_566177 V1027826 PPDK map00620,map00710,map01100,map01120 G pyruvate phosphate dikinase COG0574 Cluster_533792 V1027827 NORM V MATE efflux family protein COG0534 Cluster_533793 V1027829 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_533794 V1027830 AASI_0458 S WbqC-like 0ZW99 Cluster_533795 V1027831 C L-carnitine dehydratase bile acid-inducible protein F COG1804 Cluster_617016 V1027834 DACA map00550,map01100 M carboxypeptidase COG1686 Cluster_673164 V1027835 P Phosphate-Selective Porin O and P 10816 Cluster_533796 V1027838 T Diguanylate cyclase with PAS PAC sensor COG4191 Cluster_533797 V1027842 PEPN map00480,map01100 E Peptidase M1 membrane alanine aminopeptidase COG0308 Cluster_533798 V1027846 IOLTB G ABC transporter COG1172 Cluster_536683 V1027847 S Putative cell wall binding repeat 11PTK Cluster_533800 V1027849 S NA 0YC4S Cluster_585237 V1027850 CHEW map02020,map02030 N, T Chemotaxis protein, CheW COG0835 Cluster_533801 V1027851 PILY1 N, U Biogenesis protein COG3419 Cluster_533802 V1027852 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_533803 V1027855 V abc transporter COG1132 Cluster_533804 V1027859 RND J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) COG0349 Cluster_598868 V1027860 YRKJ S Sulfite exporter TauE/SafE COG0730 Cluster_551277 V1027862 L transposase 18D4C@proNOG Cluster_536684 V1027863 YGHJ map05111 S accessory colonization factor AcfD 16SYG@proNOG Cluster_536685 V1027864 S Phage portal protein, SPP1 Gp6-like 11SQ0 Cluster_765348 V1027865 MT0582 S conserved TRANSMEMBRANE PROTEIN 11TI5 Cluster_931365 V1027866 MGTA map00051 M Glycosyl transferase (Group 1 COG0438 Cluster_765349 V1027867 YGDI S (LipO)protein 17G6A@proNOG Cluster_536686 V1027868 XYLT map04113 G transporter 0XNQK Cluster_536687 V1027870 HFLX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COG2262 Cluster_536688 V1027872 SPOT map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_536689 V1027873 PROY E amino acid COG1113 Cluster_533805 V1027874 NUOL map00190,map00910,map01100 C subunit L COG1009 Cluster_536690 V1027877 PHBC map00650 I poly(r)-hydroxyalkanoic acid synthase, class COG3243 Cluster_536691 V1027879 BMUL_0405 Q Mammalian cell entry related domain protein COG1463 Cluster_536692 V1027883 S Protein of unknown function (DUF418) 0YAB0 Cluster_536693 V1027886 ACRB P Transporter, hydrophobe amphiphile efflux-1 (HAE1) family COG0841 Cluster_536694 V1027887 S NA 12D73 Cluster_536696 V1027889 C Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding COG1529 Cluster_640005 V1027891 S NA 0ZC4R Cluster_765351 V1027896 S RteC protein 10SVC Cluster_572470 V1027897 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG2812 Cluster_536697 V1027900 HISC map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01230 E May catalyze the transamination reaction in phenylalanine biosynthesis (By similarity) COG0079 Cluster_536698 V1027904 ARGJ map00330,map01100,map01110,map01210,map01230 E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) COG1364 Cluster_536699 V1027905 GDH map00250,map00330,map00910,map01100 E Glutamate dehydrogenase COG0334 Cluster_536700 V1027906 RLUB J Pseudouridine synthase COG1187 Cluster_628216 V1027907 S Outer membrane transport energization protein TonB 0XT73 Cluster_539547 V1027908 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120 G phosphohexose isomerase COG0166 Cluster_536701 V1027911 S Pfam:YadA 0ZHSU Cluster_560087 V1027912 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_536702 V1027913 CYNR K Transcriptional regulator 0ZWMP Cluster_536703 V1027916 S tape measure domain protein 11PSY Cluster_858527 V1027917 FOLP map00790,map01100 H dihydropteroate synthase COG0294 Cluster_710858 V1027918 FMT S decarboxylase family COG1611 Cluster_757765 V1027919 APT map00230,map01100 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) COG0503 Cluster_875087 V1027920 BMUL_0532 E lysine exporter protein LysE YggA COG1280 Cluster_720812 V1027922 RPSS map03010 J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) COG0185 Cluster_536705 V1027923 SOJ D Chromosome Partitioning Protein COG1192 Cluster_536706 V1027924 G class II Aldolase COG0235 Cluster_539548 V1027926 FIC D cell filamentation protein COG2184 Cluster_585238 V1027927 M opacity protein and 17ARQ@proNOG Cluster_536707 V1027928 WBBL M Glycosyl transferase, family 2 COG1216 Cluster_647934 V1027929 PIRIN O pirin domain protein COG1741 Cluster_875088 V1027930 CARD K Transcriptional regulator (CarD family COG1329 Cluster_536708 V1027934 CYSI map00910,map00920,map01100,map01120 C Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) COG0155 Cluster_673165 V1027935 L Transposition protein 16VFT@proNOG Cluster_635938 V1027936 RIHB map00230,map00240,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_536709 V1027938 YIDR S atp gtp-binding protein 16TET@proNOG Cluster_578789 V1027940 SCLAV_2114 S Protein of unknown function (DUF3499) 11VV4 Cluster_539550 V1027943 S NA 0YUF4 Cluster_539551 V1027944 M licD family COG3475 Cluster_562990 V1027945 S NA 0ZN4K Cluster_750759 V1027946 KTRA P domain protein COG0569 Cluster_539552 V1027947 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_536710 V1027948 YDIB S ATP-binding protein COG0802 Cluster_740711 V1027949 HRCA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) COG1420 Cluster_578790 V1027950 ERPA O iron--sulfur cluster insertion protein erpA COG0316 Cluster_539553 V1027951 S (RND) superfamily COG1033 Cluster_539554 V1027952 HSDM V HsdM N-terminal domain COG0286 Cluster_539555 V1027953 AMPC map00311,map00312,map01110,map02020 V 6-aminohexanoate-dimer hydrolase COG1680 Cluster_539556 V1027954 PCRA map03420,map03430 L Helicase COG0210 Cluster_539557 V1027955 YQFA S UPF0365 protein COG4864 Cluster_539558 V1027956 TIG O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COG0544 Cluster_539559 V1027958 S Band 7 protein COG2268 Cluster_539560 V1027959 G class II Aldolase COG0235 Cluster_737230 V1027960 S NA 0ZHU9 Cluster_928132 V1027962 S NA 11F7I Cluster_660342 V1027963 S NA 0Y25P Cluster_539561 V1027964 PITB P phosphate COG0306 Cluster_539562 V1027965 UGPC map02010 G Glycerol-3-phosphate-transporting ATPase COG3839 Cluster_539563 V1027966 MIAB J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) COG0621 Cluster_539565 V1027972 DHAL map00561,map01100 G Dihydroxyacetone kinase COG2376 Cluster_769199 V1027974 S NA 0ZHU9 Cluster_539566 V1027977 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_691206 V1027980 SSCG_03030 map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_539568 V1027984 YIAU K Transcriptional regulator 17614@proNOG Cluster_539569 V1027985 PGM map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_757767 V1027986 RFBB map00521,map00523,map01055,map01100,map01110 M dTDP-glucose 4-6-dehydratase COG1088 Cluster_812272 V1027987 RFBD map00521,map00523,map01100,map01110 M Dtdp-4-dehydrorhamnose reductase COG1091 Cluster_827754 V1027991 map02010 G extracellular solute-binding protein family 1 COG1653 Cluster_539570 V1027993 P tonB-dependent siderophore receptor 16PQB@proNOG Cluster_875090 V1027994 YQEC S selenium-dependent hydroxylase accessory protein YqeC 1787W@proNOG Cluster_843206 V1027995 YGFJ map00010,map00260,map00680,map01100,map01110,map01120,map01230 O 4-diphosphocytidyl-2c-methyl-d-erythritol synthase COG2068 Cluster_545262 V1027998 SMTA map00340,map00350,map00624,map01120 J Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) COG4123 Cluster_560088 V1027999 PLDB map00561,map00564,map01100,map04723 I Alpha Beta Hydrolase Fold protein COG2267 Cluster_539571 V1028000 MALT K Transcriptional regulator COG2909 Cluster_555005 V1279801 S NA 0XS0Q Cluster_507470 V1279803 FEPC map02010 P Abc transporter COG1120 Cluster_758740 V1279805 TCRA map02020 T Two component transcriptional regulator, winged helix family 11FPD Cluster_475914 V1279806 K Transcriptional regulator COG2932 Cluster_475915 V1279809 S Cytosolic protein COG4913 Cluster_504898 V1279810 YCIB M ErfK YbiS YcfS YnhG COG1376 Cluster_534651 V1279811 I CoA-substrate-specific enzyme activase COG1924 Cluster_543263 V1279812 GLMU map00520,map01100,map01110 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) COG1207 Cluster_475916 V1279813 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG1754 Cluster_475917 V1279814 OPUCD map02010 E Glycine betaine carnitine choline COG1174 Cluster_475918 V1279815 PYRP F permease COG2233 Cluster_475919 V1279816 S NA 11NI8 Cluster_475920 V1279817 LACZ map00052,map00511,map00600,map01100 G Glycoside hydrolase family 2 TIM barrel COG3250 Cluster_475921 V1279818 SSB map03030,map03430,map03440 L single-stranded DNA-binding protein COG0629 Cluster_586241 V1279819 YCBB map00051 M Glycosyl transferase, family 2 COG0463 Cluster_731707 V1279821 map00270,map01100 E eIF-2B alpha beta delta-like protein COG0182 Cluster_758741 V1279822 D Metal dependent phosphohydrolase COG1896 Cluster_557922 V1279824 G Alpha-1,2-mannosidase COG3537 Cluster_478106 V1279825 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_478107 V1279826 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_552113 V1279827 FUCP G glucose galactose transporter COG0738 Cluster_475922 V1279828 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_607115 V1279829 FLIA map02020,map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG1191 Cluster_540329 V1279832 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_475923 V1279833 S NA 12BGB Cluster_475924 V1279835 map05100 G s-layer domain protein 11IBF Cluster_900937 V1279838 YTFA K Transcriptional regulator, TetR family 172FP@proNOG Cluster_864211 V1279839 map00061,map00780,map01040,map01100 S Short-chain dehydrogenase reductase Sdr 17BHV@proNOG Cluster_487444 V1279840 ILVD map00290,map00770,map01100,map01110,map01210,map01230 E Dihydroxy-acid dehydratase COG0129 Cluster_497286 V1279841 ARGD map00250,map00330,map00410,map00640,map00650,map01100,map01110,map01210,map01230 E acetylornithine COG4992 Cluster_770218 V1279842 S Protein of unknown function (DUF2089) COG3877 Cluster_478108 V1279844 DGOT G Major Facilitator 0XR3C Cluster_661649 V1279847 NRDB map00230,map00240,map00480,map01100,map04115 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_888354 V1279848 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_497287 V1279850 S NA 0YZ82 Cluster_478109 V1279851 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_699441 V1279852 RPLW map03010 J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) COG0089 Cluster_637264 V1279854 S phosphoserine phosphatase 0Y1NG Cluster_475926 V1279855 K Transcriptional Regulator AraC Family COG2207 Cluster_478111 V1279858 L plasmid recombination enzyme 0ZWBR Cluster_661650 V1279860 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_478112 V1279861 CLPP map04112 O ATP-dependent Clp protease, proteolytic subunit COG0740 Cluster_478113 V1279862 TRXB map00240,map00450 O Thioredoxin reductase COG0492 Cluster_478114 V1279863 CLPB O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_478115 V1279864 E oligoendopeptidase, m3 family COG1164 Cluster_526262 V1279865 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_567152 V1279866 I o-antigen acetylase COG1835 Cluster_478116 V1279867 YBIW map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_641257 V1279868 U TraG family COG3505 Cluster_478117 V1279871 V T5orf172 0XQ8K Cluster_579804 V1279872 NATA S (ABC) transporter COG4152 Cluster_809434 V1279873 S Heavy metal-associated domain protein 1225I Cluster_785509 V1279874 CADA P cadmium-exporting ATPase COG2217 Cluster_621883 V1279875 S NA 11NDD Cluster_478118 V1279877 ACIFE_0396 L Transposase COG2801 Cluster_478119 V1279878 S 5 nucleotidase deoxy cytosolic type C 11SZB Cluster_537540 V1279879 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_478120 V1279880 WAAK map00540,map01100 M Lipopolysaccharide 1,2-N-acetylglucosaminetransferase COG0438 Cluster_864212 V1279881 ULAG map00053,map01100,map01120 S L-ascorbate 6-phosphate lactonase COG2220 Cluster_512649 V1279882 L Site-specific recombinase COG1961 Cluster_748331 V1279883 S NA 11S9B Cluster_478121 V1279885 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_596399 V1279886 GCVT map00260,map00670,map00910,map01100 E The glycine cleavage system catalyzes the degradation of glycine (By similarity) COG0404 Cluster_478123 V1279890 S phosphoesterase PA-phosphatase related protein 11K03 Cluster_805409 V1279891 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_478124 V1279892 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_725116 V1279893 V abc transporter permease protein COG0577 Cluster_478125 V1279894 map00730,map01100 H IA, variant 3 COG0637 Cluster_552114 V1279895 U TraG family COG3505 Cluster_520608 V1279896 GLF M udp-galactopyranose mutase COG0562 Cluster_478127 V1279898 S NA 0XNRI Cluster_478129 V1279900 BH0416 L Transposase COG3464 Cluster_758742 V1279901 PHOB map02020 T Two component transcriptional regulator, winged helix family COG0745 Cluster_478130 V1279902 COBW S cobalamin synthesis protein COG0523 Cluster_478131 V1279903 PHBA map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map02020 I Acetyl-CoA acetyltransferase COG0183 Cluster_480489 V1279905 S integral membrane protein 11Q41 Cluster_480490 V1279906 S Secreted protein 0XRGW Cluster_633204 V1279907 C Hydrogenase large subunit domain protein COG4624 Cluster_502485 V1279909 WECB map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_478132 V1279910 G Domain-Containing protein 11Q0T Cluster_478133 V1279911 S domain protein 0XPXI Cluster_721764 V1279912 PITA P phosphate transporter COG0306 Cluster_777608 V1279913 YKAA P phosphate transport regulator COG1392 Cluster_641258 V1279916 S NA 11PT6 Cluster_478134 V1279917 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_478135 V1279918 YOCR P transporter COG0733 Cluster_683572 V1279920 MTRA map02020 T response regulator COG0745 Cluster_801246 V1279922 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_817159 V1279923 TRXA map00240,map00450 O Thioredoxin COG0526 Cluster_618241 V1279924 GLTA map00250,map00910,map01100,map01110,map01120,map01230 E Glutamate synthase COG0543 Cluster_480491 V1279925 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_478136 V1279926 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_540330 V1279927 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_480492 V1279928 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_478137 V1279930 C FMN-binding domain protein COG3976 Cluster_576680 V1279931 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_868167 V1279932 ALKA map03410 L 8-oxoguanine DNA glycosylase COG0122 Cluster_633205 V1279933 S NA 0XY2M Cluster_478138 V1279934 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_478139 V1279935 CASA L crispr-associated protein 0XPA1 Cluster_603505 V1279936 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_537541 V1279939 CBIK map00860,map01100 H cobalt chelatase COG4822 Cluster_478140 V1279940 M Glycosyl transferase (Group 1 0XSCX Cluster_478141 V1279941 S NA 0YCKF Cluster_480493 V1279942 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_480494 V1279944 TRPE map00400,map01100,map01110,map01230 E, H Anthranilate synthase component I, N terminal region COG0147 Cluster_480495 V1279945 S NA 0ZVSK Cluster_478142 V1279946 PROB map00330,map01100,map01230 E Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) COG0263 Cluster_809435 V1279948 TRAA map03440 L mobA MobL family protein COG0507 Cluster_478143 V1279950 CLCAR_1091 T Histidine kinase COG0642 Cluster_766512 V1279951 TELA P Resistance protein COG3853 Cluster_721765 V1279952 TELA P Resistance protein COG3853 Cluster_478144 V1279953 S copper amine 121X1 Cluster_552115 V1279954 E peptidase 0XRNU Cluster_480498 V1279955 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_480499 V1279956 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_913551 V1279957 RPMA map03010 J 50S ribosomal protein l27 COG0211 Cluster_625678 V1279958 RPLU map03010 J This protein binds to 23S rRNA in the presence of protein L20 (By similarity) COG0261 Cluster_480500 V1279959 K Peptidase S24-like protein COG2932 Cluster_478145 V1279961 CSTA T Carbon starvation protein CstA COG1966 Cluster_777609 V1279963 SP_0686 S bacteriocin-associated integral membrane protein COG4652 Cluster_665862 V1279965 METI map02010 P ABC transporter, permease COG2011 Cluster_494777 V1279966 PSTA map02010 P phosphate ABC transporter (Permease COG0581 Cluster_828802 V1279967 L Dna topoisomerase COG0550 Cluster_523350 V1279968 NADB map00250,map00760,map01100 H L-aspartate oxidase COG0029 Cluster_708651 V1279970 T response regulator COG0745 Cluster_785511 V1279971 HPK1 T Histidine kinase COG0642 Cluster_480501 V1279972 L Integrase core domain protein COG2801 Cluster_480502 V1279974 MDH C malate L-lactate dehydrogenase COG2055 Cluster_480503 V1279975 COBD map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01230 E Imidazole acetol-phosphate transaminase COG0079 Cluster_480504 V1279976 F ATP cone domain COG1328 Cluster_507471 V1279979 map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aminotransferase COG0436 Cluster_480505 V1279980 G glycosidase COG2152 Cluster_480507 V1279983 TRKA P potassium transporter peripheral membrane COG0569 Cluster_480508 V1279985 PACL P Atpase, p-type (Transporting), had superfamily, subfamily ic COG0474 Cluster_480509 V1279986 YWFO S Phosphohydrolase COG1078 Cluster_721766 V1279987 YAFQ S addiction module toxin, RelE StbE family COG3041 Cluster_781425 V1279988 DINJ L Antitoxin component of a toxin-antitoxin (TA) module. A labile antitoxin that counteracts the effect of the YafQ toxin. YafQ and DinJ together bind their own promoter, and by analogy to other TA modules probably repress its expression COG3077 Cluster_482839 V1279989 V Inherit from COG: Type II restriction enzyme, methylase COG1002 Cluster_482840 V1279993 SSCG_03030 map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_480511 V1279994 YEIH S Membrane COG2855 Cluster_480513 V1279996 CAS3 L CRISPR-Associated Helicase Cas3 COG1203 Cluster_480514 V1279999 MEGL map00260,map00270,map00450,map00920,map01100,map01110,map01230 E methionine gamma-lyase COG0626 Cluster_487445 V1280000 LGAS_0613 S phage protein 125MW Cluster_510070 V1280002 CLCAR_3364 map00360,map01120 C NADH flavin oxidoreductase NADH oxidase COG1902 Cluster_482841 V1280004 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_480515 V1280005 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_480516 V1280007 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_592925 V1280010 DPPB P ABC transporter (Permease COG0601 Cluster_480517 V1280011 P hemerythrin hhe cation binding domain protein COG2461 Cluster_480518 V1280012 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_480520 V1280014 S transglutaminase domain-containing protein 0XQP2 Cluster_801247 V1280016 DTD J Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) COG1490 Cluster_482842 V1280017 SCRA map00500,map02060 G PTS system, sucrose-specific COG1264 Cluster_793307 V1280019 BFD C bacterioferritin-associated ferredoxin COG2906 Cluster_512650 V1280022 map02010 P extracellular solute-binding protein COG1840 Cluster_657446 V1280024 EXPZ S Abc transporter COG0488 Cluster_555006 V1280025 RGPD map02010 G, M ABC transporter COG1134 Cluster_482844 V1280026 AGAD map00051,map00052,map00520,map01100,map02060 G PTS system mannose fructose sorbose family IID COG3716 Cluster_480521 V1280028 M Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily COG1368 Cluster_480522 V1280029 GLNN map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG3968 Cluster_482845 V1280030 LACG map00052,map01100 G Glycosyl hydrolase family 1 COG2723 Cluster_705576 V1280031 YHCH map02010 V ABC transporter COG1131 Cluster_482846 V1280033 NAGB map00520,map01100,map01110 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COG0363 Cluster_482847 V1280036 HSDS V Type I restriction modification DNA specificity domain COG0732 Cluster_482848 V1280038 map00311,map00312,map01110,map02020 V Inherit from COG: Beta-lactamase COG2367 Cluster_705577 V1280039 COAA map00770,map01100 H pantothenic acid kinase COG1072 Cluster_721767 V1280040 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_665863 V1280043 PGSA map00564,map01100 I cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase COG0558 Cluster_678998 V1280045 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_482849 V1280046 S RelA SpoT domain protein COG2357 Cluster_523351 V1280049 PROC map00330,map01100,map01110,map01230 E pyrroline-5-carboxylate reductase COG0345 Cluster_560973 V1280051 YHBJ S Displays ATPase and GTPase activities (By similarity) COG1660 Cluster_557923 V1280052 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_482850 V1280054 BPR_I0156 L transposase COG1943 Cluster_482851 V1280055 S NA 0ZWJI Cluster_482852 V1280056 S NA 0YE9Q Cluster_688003 V1280058 ARSC T Protein-tyrosine phosphatase, low molecular weight COG0394 Cluster_482853 V1280060 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_543264 V1280061 G Transporter 0YNZ3 Cluster_482854 V1280062 G 4-alpha-glucanotransferase COG1640 Cluster_482855 V1280063 TRAJ S conjugative transposon 0XP5P Cluster_520609 V1280064 GLNN map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG3968 Cluster_637265 V1280065 K Transcriptional regulator, luxr family 0YC2M Cluster_657448 V1280067 S HutD COG3758 Cluster_482856 V1280068 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_482857 V1280069 TRMA J Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) COG2265 Cluster_708652 V1280070 ASP S alkaline shock protein COG1302 Cluster_485153 V1280071 NHAC map00680 C Na H antiporter COG1757 Cluster_549226 V1280073 XDHA map00230,map01100,map01120 C Xanthine dehydrogenase COG1529 Cluster_482858 V1280074 AMIA M n-acetylmuramoyl-l-alanine amidase COG0860 Cluster_485154 V1280075 CSD1 L CRISPR-associated protein Csd1 family 0ZVNC Cluster_485155 V1280076 S NA 0YD95 Cluster_482859 V1280077 CLC P Chloride channel COG0038 Cluster_482860 V1280078 C Aldo keto reductase COG1453 Cluster_482862 V1280080 PPAC map00190 C Manganese-dependent inorganic pyrophosphatase COG1227 Cluster_482863 V1280081 HFLX S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COG2262 Cluster_692424 V1280082 LEGAS_1040 L transposase COG2963 Cluster_576681 V1280084 TIG O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COG0544 Cluster_603506 V1280086 S Membrane COG2510 Cluster_482864 V1280087 map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aminotransferase COG0436 Cluster_512651 V1280088 PHOP map02020 T response regulator 11FPD Cluster_485156 V1280090 YJJW O activating enzyme COG1180 Cluster_482865 V1280091 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_482866 V1280092 S Membrane COG0628 Cluster_482867 V1280094 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_567154 V1280095 S Dehydrogenase reductase COG0300 Cluster_485157 V1280097 PLAV_1177 L DNA methylase n-4 n-6 domain protein 0XQ84 Cluster_573473 V1280099 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins COG0706 Cluster_563951 V1280100 L Transposase, Mutator family COG3328 Cluster_896598 V1280102 FUMB map00020,map00630,map00720,map01100,map01110,map01120 C fumarate COG1951 Cluster_520610 V1280103 map00550 S virulence factor MVIN family protein 0YTDJ Cluster_688004 V1280105 PHOB map02020 T response regulator COG0745 Cluster_482868 V1280106 S domain protein 0XPXI Cluster_637266 V1280108 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 Cluster_485158 V1280109 CYDC map02010 V Abc transporter COG1132 Cluster_485159 V1280111 T response regulator COG0745 Cluster_515369 V1280112 S Membrane 11U5A Cluster_482869 V1280113 YBEF K Transcriptional regulator 17422@proNOG Cluster_485161 V1280115 NATB map02010,map02020 V ABC, transporter COG1668 Cluster_482870 V1280116 S NA 0XNPT Cluster_485162 V1280117 APBE H ApbE family COG1477 Cluster_637267 V1280120 PHZF S phenazine biosynthesis protein, phzf family COG0384 Cluster_485163 V1280123 ACRB P Transporter, hydrophobe amphiphile efflux-1 (HAE1) family COG0841 Cluster_805411 V1280124 YQEH K protein with bipartite regulator domain 17DZY@proNOG Cluster_485164 V1280125 C radical SAM domain protein COG0731 Cluster_641259 V1280127 ARAC8 K transcriptional regulator (AraC 11G16 Cluster_607116 V1280128 OPPC P Binding-protein-dependent transport systems inner membrane component COG1173 Cluster_917883 V1280129 OPPB1 P Binding-protein-dependent transport systems inner membrane component COG0601 Cluster_485165 V1280131 MURE map00300,map00550,map01100 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_520611 V1280132 HSLO O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) COG1281 Cluster_888357 V1280133 ARGG map00250,map00330,map01100,map01110,map01230 E Citrulline--aspartate ligase COG0137 Cluster_721768 V1280134 RECX map00561,map01100 M Glycosyl transferase (Group 1 COG0438 Cluster_485166 V1280136 HSDM V type I restriction-modification system COG0286 Cluster_485167 V1280138 L Phage Integrase Family 0ZVXC Cluster_728443 V1280139 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_599893 V1280140 K Transcriptional regulator, ARAC family 125DJ Cluster_592926 V1280142 S UPF0272 protein COG1641 Cluster_485168 V1280143 PURL F phosphoribosylformylglycinamidine synthase COG0047 Cluster_715203 V1280144 ELI_1299 S Phage major capsid protein COG4653 Cluster_485169 V1280145 map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_485170 V1280147 O Hsc56 co-chaperone of HscC 17H23@proNOG Cluster_485171 V1280149 ARAA map00040,map01100 G Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) COG2160 Cluster_487446 V1280151 HEMA map00860,map01100,map01110 H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) COG0373 Cluster_485172 V1280152 YHCF S response to DNA damage stimulus 17FX4@proNOG Cluster_487447 V1280153 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_487448 V1280154 S pyridine nucleotide-disulfide oxidoreductase 11I5C Cluster_801249 V1280155 S NA 11G6R Cluster_828804 V1280156 GALK map00052,map00520,map01100,map01110 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) COG0153 Cluster_741679 V1280157 GALT map00052,map00520,map01100,map01110 G UDP-glucose-hexose-1-phosphate uridylyltransferase COG4468 Cluster_485173 V1280159 SP_2113 S membrAne COG1284 Cluster_485174 V1280160 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_821050 V1280161 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_688005 V1280162 PURN map00230,map00670,map01100,map01110 F phosphoribosylglycinamide formyltransferase COG0299 Cluster_817161 V1280163 S NA 0XRJA Cluster_633206 V1280165 SCPA S Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) COG1354 Cluster_618244 V1280168 S NA 11TST Cluster_487449 V1280169 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_502486 V1280170 map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_645143 V1280171 RPSM map03010 J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits COG0099 Cluster_670174 V1280173 CAT map00281,map00620,map00626,map01110,map01120 C Transferase COG0427 Cluster_485177 V1280175 NRDE map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_485178 V1280176 COMEA L Competence protein COG1555 Cluster_485179 V1280177 S NA 11VJW Cluster_487450 V1280180 ETFB map00910 C Electron transfer flavoprotein COG2086 Cluster_487451 V1280181 L DNA primase 11GUV Cluster_708653 V1280182 PITRM1 O peptidase COG1026 Cluster_487452 V1280183 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_785514 V1280184 PLPD S K07001 NTE family protein COG1752 Cluster_487453 V1280185 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_487454 V1280186 S Pentapeptide repeat protein COG1357 Cluster_487455 V1280188 PLDB map00564 I alpha beta COG2267 Cluster_485181 V1280191 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_487456 V1280192 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_607117 V1280195 RFBA map00521,map00523,map01100,map01110 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) COG1209 Cluster_610769 V1280198 NORM V MATE efflux family protein COG0534 Cluster_489793 V1280199 C Flavodoxin COG0716 Cluster_683573 V1280201 C Hydrogenase large subunit domain protein COG4624 Cluster_592927 V1280203 map02010 E, P Oligopeptide dipeptide ABC transporter, ATPase subunit COG0444 Cluster_485183 V1280207 ATPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_836424 V1280208 S YcfA-like protein 0ZAAU Cluster_892471 V1280209 S Toxin-antitoxin system, antitoxin component, HicB family 12518 Cluster_560974 V1280210 YPUA S secreted protein COG4086 Cluster_487457 V1280211 K Peptidase S24-like COG2932 Cluster_487458 V1280212 G carbohydrate kinase, YjeF related protein COG0063 Cluster_515370 V1280213 L Resolvase, N-terminal domain protein COG1961 Cluster_504899 V1280214 S NA 0YDSU Cluster_876279 V1280215 DEGV S degv family COG1307 Cluster_725118 V1280216 SP_0239 S UPF0210 protein COG2848 Cluster_487459 V1280217 GLPA map00564 C anaerobic glycerol-3-phosphate dehydrogenase, subunit A COG0578 Cluster_625679 V1280219 S Transposase domain (DUF772) 0ZNKX Cluster_529020 V1280220 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_487460 V1280221 map00052,map00511,map00600,map01100 G Glycoside hydrolase family 2 COG3250 Cluster_487461 V1280222 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_487462 V1280223 PYRK C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) COG0543 Cluster_487463 V1280224 V abc transporter permease protein 0ZW5X Cluster_487464 V1280226 MPRF map05150 J Membrane COG2898 Cluster_641260 V1280227 AADK S Aminoglycoside 6-adenylyltransferase 0YSKJ Cluster_621884 V1280229 VANR T response regulator COG0745 Cluster_487465 V1280230 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_762558 V1280231 S NA 0YHJ9 Cluster_748333 V1280232 S DNA-binding protein COG3943 Cluster_489794 V1280233 L transposase, IS605 OrfB COG0675 Cluster_487466 V1280234 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_487467 V1280235 YGDR E Transporter COG3104 Cluster_520613 V1280236 CSE4 L Crispr-associated protein, cse4 family 0Y6PV Cluster_489795 V1280237 S NA 0YH2T Cluster_489796 V1280238 S YitT family COG1284 Cluster_534652 V1280241 G Major Facilitator COG2814 Cluster_573474 V1280243 FOLT S Membrane 11R75 Cluster_489797 V1280248 S P-loop domain protein 0XQDB Cluster_520614 V1280249 NTPF S H -ATPase, subunit H 122TR Cluster_489798 V1280250 TRXB map00240,map00450 O thioredoxin reductase COG0492 Cluster_489799 V1280251 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_748334 V1280252 S Conserved hypothetical protein 2217 (DUF2460) 0YITT Cluster_487469 V1280253 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_487470 V1280254 S NA 0XT0J Cluster_762559 V1280255 DEOB map00030,map00230 G Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) COG1015 Cluster_661651 V1280256 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_852079 V1280257 V abc transporter permease protein 0XQE2 Cluster_492290 V1280258 HPPA map00190 C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for COG3808 Cluster_487471 V1280259 CAPA M synthesis protein COG2843 Cluster_487472 V1280261 ARAJ G Major Facilitator COG2814 Cluster_748335 V1280262 THIP map02010 P binding-protein-dependent transport systems inner membrane Component COG1178 Cluster_489800 V1280265 S cell wall assembly cell proliferation coordinating protein, KNR4-like protein COG4859 Cluster_489801 V1280266 L site-specific recombinase, phage integrase family 10A1H Cluster_487473 V1280268 E Family 5 COG0747 Cluster_570239 V1280269 GCTA map00643,map00650,map01120 I coenzyme A transferase COG1788 Cluster_531865 V1280270 map00310,map00780,map01100 O peptidase, M16 COG0612 Cluster_621885 V1280272 YHFW map00030,map00230 G Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) COG1015 Cluster_896601 V1280273 YHFX E Racemase COG3457 Cluster_534653 V1280276 MMDC map00061,map00253,map00620,map00640,map00720,map01100,map01110,map01120 I biotin lipoyl attachment domaiN-containing protein COG4770 Cluster_579806 V1280277 LDTA S ErfK YbiS YcfS YnhG COG1376 Cluster_487474 V1280279 YEII map00240 G kinase (PfkB family COG0524 Cluster_489802 V1280280 S NA 101IJ Cluster_489804 V1280282 FTSW D cell cycle protein COG0772 Cluster_557925 V1280283 MUTF map02010 V ABC transporter, ATP-binding protein COG1131 Cluster_489805 V1280284 map03070 U general secretion pathway protein D COG1450 Cluster_489806 V1280285 APRE O Peptidase S8 and S53 subtilisin kexin sedolisin COG4412 Cluster_489807 V1280288 PYRC map00240,map01100 F Dihydroorotase COG0044 Cluster_489808 V1280289 S Inherit from NOG: Cell surface protein 0XPAZ Cluster_489809 V1280290 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_489810 V1280291 PEPC E aminopeptidase c COG3579 Cluster_515371 V1280292 PYRC map00240,map01100 F Dihydroorotase COG0044 Cluster_489811 V1280293 S Ragb susd domain-containing protein 0XR0J Cluster_489812 V1280295 FADD35 map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG0318 Cluster_489813 V1280298 E amidohydrolase COG1473 Cluster_621886 V1280299 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins COG0706 Cluster_540331 V1280301 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_492291 V1280302 S NA 11NI8 Cluster_592928 V1280303 YQFA S hemolysin iii COG1272 Cluster_492292 V1280305 HTPG map04141,map04151,map04612,map04621,map04626,map04914,map04915,map05200,map05215 O Molecular chaperone. Has ATPase activity (By similarity) COG0326 Cluster_683574 V1280306 S NA 17HVW@proNOG Cluster_492293 V1280307 M Lysm domain COG1388 Cluster_489815 V1280308 L Inherit from COG: transposase COG3666 Cluster_777610 V1280311 RPOD map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_494778 V1280312 Q Methyltransferase Type COG0500 Cluster_507472 V1280313 Q abc transporter atp-binding protein COG1127 Cluster_586242 V1280314 COMEB map00240,map01100 F deaminase COG2131 Cluster_492294 V1280315 M domain protein COG4932 Cluster_489817 V1280318 WAAK map00540,map01100 M Lipopolysaccharide 1,2-N-acetylglucosaminetransferase COG0438 Cluster_492295 V1280319 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_762560 V1280320 FOPA M ompA family 10ZT3 Cluster_507473 V1280321 ASRB C sulfite reductase subunit b COG0543 Cluster_489819 V1280323 ISPD map00900,map01100,map01110 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COG1211 Cluster_489820 V1280324 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_744985 V1280325 L Transposase COG0675 Cluster_534654 V1280327 S EamA-like transporter family 11JWD Cluster_492296 V1280328 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_492297 V1280330 COBU map00860,map01100 H Adenosylcobinamide kinase COG2087 Cluster_492299 V1280333 RPSG map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) COG0049 Cluster_592929 V1280334 HLYB map02010,map03070,map05133 U Type I secretion system ATPase COG2274 Cluster_492300 V1280335 map02020 T Histidine kinase COG0642 Cluster_537542 V1280336 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_529021 V1280337 K transcriptional regulator COG1414 Cluster_492301 V1280338 map00511,map04142 G hydrolase family 2, sugar binding COG3250 Cluster_492302 V1280339 E dipeptide-binding protein COG0747 Cluster_555008 V1280340 RAIA J sigma 54 modulation protein ribosomal protein S30ea COG1544 Cluster_492303 V1280341 TIG O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COG0544 Cluster_502487 V1280343 V Mate efflux family protein COG0534 Cluster_489822 V1280344 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_546195 V1280349 FLU M, U antigen 43 COG3468 Cluster_718468 V1280350 MNOD_0308 map02010 L Transposase COG3666 Cluster_781426 V1280351 L Inherit from COG: transposase COG3666 Cluster_494779 V1280352 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_531866 V1280353 PCM O Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) COG2518 Cluster_621887 V1280354 PEPF map04614,map05143 E Oligoendopeptidase f COG1164 Cluster_492304 V1280357 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_489825 V1280359 O Bacterial trigger factor protein (TF) C-terminus COG0544 Cluster_492305 V1280360 YGGF G Fructose-1,6-bisphosphatase COG1494 Cluster_492306 V1280362 T Histidine kinase COG5002 Cluster_499949 V1280363 P Binding-protein-dependent transport systems inner membrane component 0XNPF Cluster_758745 V1280364 TYPA T gtp-binding protein typa COG1217 Cluster_653327 V1280365 MUTY map03410 L a g-specific adenine glycosylase COG1194 Cluster_492307 V1280366 YERB S secreted protein 11FHM Cluster_492309 V1280370 map00051 M Glycosyl transferase (Group 1 COG0438 Cluster_492310 V1280371 DSBD O Thiol disulfide interchange protein COG4232 Cluster_492311 V1280372 S NA 1002Y Cluster_492312 V1280373 RFAC map00540,map01100 M lipopolysaccharide heptosyltransferase i COG0859 Cluster_702474 V1280374 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_621888 V1280375 Q Oxaloacetate decarboxylase, gamma chain 0XY4W Cluster_633207 V1280376 L resolvase, n-terminal domain protein COG1961 Cluster_534655 V1280377 S NA 0YXIR Cluster_492313 V1280379 TRXB map00240,map00450 O thioredoxin reductase COG0492 Cluster_728444 V1280381 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_492314 V1280382 SKFE map02010 V Abc transporter COG1131 Cluster_492315 V1280383 map02010 S NA 0XSAQ Cluster_492316 V1280384 MOP map00230,map01100,map01120 C Xanthine dehydrogenase COG2080 Cluster_492317 V1280385 YJCO S Uncharacterized protein yjcO COG0790 Cluster_492318 V1280386 REPA L Replication initiator protein A 0Y2JJ Cluster_507474 V1280387 SPOU J rrna methyltransferase COG0566 Cluster_683575 V1280388 L Helicase associated domain COG1061 Cluster_492319 V1280389 S Inherit from NOG: peptidase inhibitor activity 0XX92 Cluster_645144 V1280392 YCSG P transporter COG1914 Cluster_492320 V1280393 PROB map00330,map01100,map01230 E Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) COG0263 Cluster_805413 V1280394 LRGB map02020 M lrgb family COG1346 Cluster_702475 V1280395 LRGA map02020 S lrga family COG1380 Cluster_510072 V1280396 T ATPase histidine kinase DNA gyrase B HSP90 domain protein 11IP0 Cluster_805414 V1280397 SP_1531 S conserved domain protein 0XW6H Cluster_579807 V1280398 LSPA map03060 U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) COG0597 Cluster_570240 V1280399 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_494780 V1280402 V Mate efflux family protein COG0534 Cluster_758746 V1280403 RNY S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 Cluster_492321 V1280406 SDHA map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020,map05134 C succinate dehydrogenase, flavoprotein subunit COG1053 Cluster_492322 V1280407 E, G EamA-like transporter family COG0697 Cluster_492323 V1280409 U, W Domain-Containing protein COG5295 Cluster_534656 V1280410 map00360 E amidohydrolase COG1473 Cluster_540332 V1280411 O Peptidylprolyl isomerase COG0760 Cluster_855859 V1280413 ADIY K Transcriptional regulator 177DQ@proNOG Cluster_492324 V1280414 YACL S PilT protein domain protein COG4956 Cluster_526263 V1280415 K Transcriptional Regulator AraC Family 0ZYR5 Cluster_492325 V1280416 RUMA map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_494781 V1280417 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_531867 V1280420 ILVA map00260,map00290,map01100,map01110,map01230 E Threonine dehydratase COG1171 Cluster_809437 V1280421 HYPA C Hydrogenase nickel incorporation protein COG0375 Cluster_711850 V1280422 HYPB K, O Hydrogenase accessory protein HypB COG0378 Cluster_492326 V1280423 S NA 0YRIH Cluster_494782 V1280424 RSMI G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 Cluster_507475 V1280425 RLMB map00340,map00350,map00624,map01120 J RNA methyltransferase TrmH family group 3 COG0566 Cluster_728445 V1280426 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_494783 V1280427 map00360 E amidohydrolase COG1473 Cluster_492327 V1280428 RNY S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 Cluster_728446 V1280430 map00190,map00680,map01100 C ATP synthase subunit C 11URT Cluster_494784 V1280431 YUFO S ABC transporter COG3845 Cluster_678999 V1280432 S Phage integrase family 0Z2PR Cluster_625681 V1280433 MOEB map00730,map01100,map04122 H uba thif-type nad fad binding protein COG0476 Cluster_492329 V1280435 RECC map03440 L exodeoxyribonuclease V, gamma COG1330 Cluster_872173 V1280437 NDVA2 V ABC transporter, ATP-binding protein COG1132 Cluster_492330 V1280438 GLNP E amino acid AbC transporter COG0765 Cluster_494785 V1280439 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_688006 V1280441 TRXA O Thioredoxin COG0526 Cluster_494786 V1280442 S Ragb susd domain-containing protein 11JEB Cluster_629381 V1280443 V Abi-like protein COG4823 Cluster_645145 V1280445 JAG S Single-stranded nucleic acid binding R3H domain-containing protein COG1847 Cluster_715204 V1280446 FLIE map02040 N flagellar hook-basal body complex protein fliE 124UN Cluster_805416 V1280447 FLIF map02040 N The M ring may be actively involved in energy transduction (By similarity) COG1766 Cluster_494787 V1280448 S Pentapeptide repeat protein COG1357 Cluster_494788 V1280449 S NA 0YG6V Cluster_560975 V1280450 map00270,map00330,map00410,map00480,map01100 S synthase 0ZXB1 Cluster_494789 V1280451 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_618245 V1280455 RPST map03010 J Binds directly to 16S ribosomal RNA (By similarity) COG0268 Cluster_494790 V1280456 HYDE map00780,map01100 H radical SAM domain protein COG0502 Cluster_492331 V1280457 map00270,map00450,map00670,map01100,map01110,map01230 E Methylenetetrahydrofolate reductase COG0646 Cluster_653328 V1280458 MURQ map00520 G Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate COG2103 Cluster_494791 V1280460 YISQ V Mate efflux family protein COG0534 Cluster_494792 V1280461 L Inherit from COG: Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0550 Cluster_494793 V1280462 ADDB L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination COG3857 Cluster_494794 V1280463 P transporter COG0733 Cluster_618246 V1280464 RIMP S Required for maturation of 30S ribosomal subunits (By similarity) COG0779 Cluster_777611 V1280465 GLDA map00561,map01100 C glycerol dehydrogenase COG0371 Cluster_696162 V1280468 PLDB map00564 I alpha beta COG2267 Cluster_494795 V1280469 PNTA map00760,map01100 C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) COG3288 Cluster_494796 V1280470 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_494797 V1280472 UVRD map03420,map03430 L ATP-dependent DNA helicase pcra COG0210 Cluster_679000 V1280475 CAS6 S CRISPR-associated protein cas6 COG5551 Cluster_637268 V1280476 RPIB map00030,map00710,map01100,map01110,map01120,map01230 G isomerase COG0698 Cluster_494798 V1280478 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_674566 V1280480 CCML E ethanolamine utilization protein EutN carboxysome structural protein Ccml COG4576 Cluster_494800 V1280482 L Reverse transcriptase (RNA-dependent DNA polymerase) COG3344 Cluster_586243 V1280483 SUN map00340,map00350,map00624,map01120 J NOL1 NOP2 sun family protein COG0144 Cluster_494802 V1280485 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_494803 V1280486 ZNUA map02010 P transporter substrate-binding protein COG0803 Cluster_494804 V1280487 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_494805 V1280488 S phage protein 0XQDU Cluster_692425 V1280489 map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G, K ROK family COG1940 Cluster_494806 V1280490 M nlpC P60 family protein COG0791 Cluster_900940 V1280492 YHBJ S Displays ATPase and GTPase activities (By similarity) COG1660 Cluster_607118 V1280493 YBHK S UPF0052 protein COG0391 Cluster_523352 V1280495 CHRA P Chromate COG2059 Cluster_592930 V1280497 SLGD_00086 S Ser Thr phosphatase family protein COG1409 Cluster_683576 V1280498 GYAR map00260,map00630,map00680,map01100,map01120,map01230 C Dehydrogenase COG1052 Cluster_855860 V1280499 HUTG map00330,map00340,map01100 E formiminoglutamate hydrolase COG0010 Cluster_629382 V1280500 I protein, conserved in bacteria COG3581 Cluster_497288 V1280501 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_828805 V1280502 TTCA D Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) COG0037 Cluster_543265 V1280504 RBR C Rubrerythrin COG1592 Cluster_497289 V1280505 RC1_2786 L transposase COG5433 Cluster_494808 V1280506 YKAA P phosphate transport regulator COG1392 Cluster_705579 V1280507 S NA 11QY9 Cluster_497290 V1280508 N Cell surface protein 1CAVF@tenNOG Cluster_494809 V1280510 S NA 0YDXY Cluster_494810 V1280511 PYC map00020,map00620,map00720,map01100,map01120,map01230 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) COG1038 Cluster_497291 V1280512 L Inherit from COG: Integrase COG0582 Cluster_497292 V1280513 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_510075 V1280515 map03440 L ATP-dependent exodnase (exonuclease v) COG0507 Cluster_494811 V1280516 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_494812 V1280517 E Aminotransferase COG0436 Cluster_510076 V1280518 S NA 123IR Cluster_497294 V1280519 AMYA2 map00500,map01100,map04973 G Alpha-amylase COG0366 Cluster_705580 V1280524 ISCU C SUF system FeS assembly protein COG0822 Cluster_497296 V1280529 S NA 0ZADN Cluster_832606 V1280530 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_583049 V1280531 DCTP C symporter COG1301 Cluster_607119 V1280534 RPLJ map03010 J 50s ribosomal protein L10 COG0244 Cluster_567155 V1280537 S NA 11THP Cluster_497297 V1280538 MALQ map00500,map01100,map01110 G 4-alpha-glucanotransferase COG1640 Cluster_523353 V1280539 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_762562 V1280540 E, T ABC, transporter COG0834 Cluster_563953 V1280542 map02020,map02030 T Histidine kinase 16PBK@proNOG Cluster_497298 V1280543 P K -dependent Na -Ca exchanger COG0530 Cluster_494815 V1280544 YBJX S VirK protein COG2990 Cluster_629383 V1280545 DNAX map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG2812 Cluster_494816 V1280547 P tonB-dependent Receptor 0XP5Y Cluster_494817 V1280548 S Inherit from COG: LOR SDH bifunctional protein conserved domain protein COG1915 Cluster_494818 V1280549 S NA 11P3R Cluster_494819 V1280550 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_497299 V1280551 MGTA P magnesium-translocating p-type atpase COG0474 Cluster_748337 V1280552 MOAB map00790,map01100,map04122 H Molybdenum cofactor synthesis domain protein COG0521 Cluster_864217 V1280553 MOAB map00790,map01100,map04122 H Molybdenum cofactor synthesis domain protein COG0521 Cluster_497301 V1280555 SP_1221 V restriction 0XQ8K Cluster_497302 V1280556 YIDC map03060,map03070 U Membrane COG0706 Cluster_497303 V1280557 YCJV map02010 G Abc transporter COG3839 Cluster_515372 V1280558 map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020 C fumarate reductase succinate dehydrogenase flavoprotein domain protein COG1053 Cluster_529022 V1280560 UDK map00240,map00983,map01100 F uridine kinase COG0572 Cluster_497304 V1280561 S tetrapyrrole methylase COG3956 Cluster_529023 V1280562 FUCA map00051,map00053,map01100,map01120 G Aldolase COG0235 Cluster_499950 V1280563 DCM map04112 L DNA Methylase COG1475 Cluster_497305 V1280564 map00330 S K01470 creatinine amidohydrolase EC 3.5.2.10 COG1402 Cluster_560976 V1280566 CVRA P Participates in control of cell volume in low-osmolarity conditions (By similarity) COG3263 Cluster_526264 V1280568 CYCA E amino acid COG1113 Cluster_497306 V1280569 GRAS map02020 T Histidine kinase COG0642 Cluster_777612 V1280570 K transcriptional regulator, lysR family COG0583 Cluster_497308 V1280573 MURF map00300,map00550,map01100 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) COG0770 Cluster_515373 V1280574 GLGC map00500,map00520,map01100,map01110 G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) COG0448 Cluster_497309 V1280575 COMM O Mg chelatase subunit ChlI COG0606 Cluster_497310 V1280576 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_711851 V1280577 S ATPase AAA superfamily 0XSDB Cluster_497311 V1280578 I Diacylglycerol kinase COG1597 Cluster_497312 V1280579 map02020,map02030 P Methyl-accepting chemotaxis sensory transducer 17ERZ@proNOG Cluster_596401 V1280580 SLGD_00062 S membrAne 11F2H Cluster_751774 V1280582 LGAS_0606 S Phage Portal Protein 0XP33 Cluster_789511 V1280583 RSME S Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) COG1385 Cluster_734958 V1280584 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_497313 V1280585 RECB map03440 L UvrD REP helicase COG1074 Cluster_555009 V1280586 T Tetratricopeptide repeat COG0790 Cluster_497314 V1280589 CCPA K Transcriptional regulator, LacI family COG1609 Cluster_499951 V1280590 ARCA map00330,map01100,map01110 E Arginine dihydrolase COG2235 Cluster_721769 V1280592 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_497315 V1280593 TAUA map02010 P ABC transporter substrate-binding protein COG0715 Cluster_497316 V1280594 UHPT P Major Facilitator COG0477 Cluster_499953 V1280595 YNCB map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120 S Alcohol dehydrogenase zinc-binding domain protein COG2130 Cluster_781427 V1280596 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_741680 V1280597 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_497317 V1280599 LIVK map02010 E Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein COG0683 Cluster_670175 V1280602 YQFL S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) COG1806 Cluster_497319 V1280604 S fmN-binding domain protein COG3976 Cluster_497320 V1280605 S NA 11UZG Cluster_526265 V1280606 E Formiminotransferase-cyclodeaminase COG3404 Cluster_497321 V1280607 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_497322 V1280608 CARA map00240,map00250,map01100 F carbamoyl-phosphate synthetase glutamine chain COG0505 Cluster_499954 V1280609 C FMN-binding domain protein COG3976 Cluster_497323 V1280612 GLTB map00250,map00630,map00910,map01100,map01110,map01120,map01230 E Class II glutamine amidotransferase COG0070 Cluster_614490 V1280615 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_679001 V1280616 ASTA S Arylsulfotransferase 174ZE@proNOG Cluster_499955 V1280617 PUCG map00250,map00260,map00630,map00680,map01100,map01110,map01120,map04146 E Aminotransferase COG0075 Cluster_744987 V1280618 SP_1863 K Transcriptional regulator, MarR family COG1846 Cluster_499956 V1280619 S Exporters of the RND superfamily COG1033 Cluster_497324 V1280620 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_618247 V1280621 S NA 11ISA Cluster_497325 V1280622 CLPC O Clp protease ATP-binding subunit COG0542 Cluster_499957 V1280623 YACH S exported protein 175WZ@proNOG Cluster_499958 V1280624 XKDP S Inherit from COG: domain protein COG1652 Cluster_499959 V1280625 UVRD map03420,map03430 L ATP-dependent DNA helicase pcra COG0210 Cluster_589521 V1280626 E Dipeptidase COG4690 Cluster_497326 V1280627 COBD map00860,map01100 H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) COG1270 Cluster_499960 V1280629 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_715205 V1280630 PPSA S pyruvate phosphate dikinase 0XRDW Cluster_633209 V1280631 GND map00030,map00480,map01100,map01110,map01120 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) COG0362 Cluster_702476 V1280632 SUFB O SufB sufD domain protein COG0719 Cluster_828806 V1280633 SUFB O FeS assembly protein SUFB COG0719 Cluster_497327 V1280634 GLPK map00561,map01100,map03320,map04626 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 Cluster_499961 V1280636 RESC O cytochrome C COG0755 Cluster_499962 V1280638 E, G Membrane COG0697 Cluster_510077 V1280639 S NA 0YKJW Cluster_852082 V1280640 S domain protein 1009W Cluster_633210 V1280642 GMUD map00010,map00460,map00500,map00940,map01100,map01110 G beta-glucosidase COG2723 Cluster_499963 V1280643 T two-component system sensor histidine kinase response regulator, hybrid 0XNMH Cluster_499964 V1280644 map00230,map01100,map01120 O Xanthine dehydrogenase accessory factor COG1975 Cluster_499965 V1280645 L type iii restriction protein res subunit COG4951 Cluster_499966 V1280646 PBP1A map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_499967 V1280648 CUEO map00860 Q Multicopper oxidase COG2132 Cluster_576682 V1280649 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG0194 Cluster_499968 V1280652 F ATP cone domain COG1328 Cluster_499969 V1280653 S oxidoreductase 0XP5M Cluster_661652 V1280654 MNME S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 Cluster_762563 V1280655 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_499970 V1280656 map03420,map03430 L helicase COG3973 Cluster_499971 V1280657 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_499973 V1280659 S (LipO)protein 0XSFR Cluster_748338 V1280660 S NA 0XRP2 Cluster_499974 V1280661 CYSK map00270,map00920,map01100,map01120,map01230 E Cysteine synthase COG0031 Cluster_741681 V1280662 P Ferrous iron transport protein b COG0370 Cluster_801251 V1280663 RARD S rard protein COG2962 Cluster_499975 V1280665 PYRE map00240,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_499976 V1280666 map02010 G solute-binding protein 11H5G Cluster_499977 V1280667 L site-specific recombinase XerD 0XS3W Cluster_502489 V1280670 map00362,map01100,map01120 S Alpha beta hydrolase COG0596 Cluster_555010 V1280671 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_499978 V1280672 SRTB U sortase, SrtB family COG4509 Cluster_560977 V1280673 ILVN map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E synthase) (Small subunit) COG0440 Cluster_537543 V1280674 SRTC M (sortase) family COG3764 Cluster_499979 V1280675 O ADP-ribosylglycohydrolase COG1397 Cluster_515374 V1280676 T ATPase histidine kinase DNA gyrase B HSP90 domain protein 0XNMH Cluster_529024 V1280677 map00230,map00760,map01100 F inosine uridine-preferring nucleoside hydrolase COG1957 Cluster_502490 V1280678 SELU S Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) COG2603 Cluster_502491 V1280679 HLYX P CBS domain protein COG1253 Cluster_502492 V1280680 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_502493 V1280681 ACTP P copper-exporting ATPase COG2217 Cluster_499980 V1280682 P TonB-linked outer membrane protein, SusC RagA family 0ZWIF Cluster_557926 V1280684 YABB map00340,map00350,map00624,map01120 L Methyltransferase COG4123 Cluster_499981 V1280686 OPPA2 E ABC transporter substrate-binding protein COG0747 Cluster_499982 V1280687 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_573475 V1280688 HSDR V Type I Restriction COG0610 Cluster_499983 V1280689 PANC map00410,map00770,map01100,map01110 H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) COG0414 Cluster_692426 V1280690 YEGQ map05120 O Peptidase U32 COG0826 Cluster_744988 V1280692 GLTA map00020,map00630,map00640,map01100,map01110,map01120,map01210,map01230 C Citrate synthase COG0372 Cluster_499985 V1280696 S NA 11QVU Cluster_499986 V1280697 V Beta-lactamase COG1680 Cluster_560978 V1280701 CODB F permease for cytosine purines, uracil, thiamine, allantoin COG1457 Cluster_661653 V1280702 RPOD map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_570241 V1280704 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0847 Cluster_801252 V1280705 ADH map00010,map00051,map00071,map00350,map00362,map00363,map00561,map00591,map00620,map00621,map00622,map00625,map00626,map00630,map00650,map01100,map01110,map01120 C iron-containing alcohol dehydrogenase COG1454 Cluster_534657 V1280706 RPOS map05111 K RNA polymerase COG0568 Cluster_502494 V1280707 YHJG M asmA family COG2982 Cluster_534658 V1280709 ENGB S Necessary for normal cell division and for the maintenance of normal septation (By similarity) COG0218 Cluster_502496 V1280714 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_499989 V1280715 PBUG S Xanthine uracil vitamin C permease COG2252 Cluster_502497 V1280716 HPPA map00190 C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for COG3808 Cluster_546197 V1280717 S NA 11F7I Cluster_502498 V1280718 YEIH S Membrane COG2855 Cluster_502499 V1280721 L site-specific recombinase, phage integrase family 0ZJK4 Cluster_629384 V1280723 map02010 P ABC transporter, permease COG1175 Cluster_502500 V1280724 NHAA map00680 P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) COG3004 Cluster_499991 V1280727 NUOI map00190,map00910,map01100 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) COG1143 Cluster_502501 V1280728 M NA 0YDBK Cluster_789512 V1280730 S NA 0ZHU9 Cluster_502502 V1280731 DALK_0900 L transposase (IS4 family) protein 0XQ88 Cluster_529025 V1280733 S NA 11G8Y Cluster_502503 V1280734 SGLY_0561 L reverse transcriptase COG3344 Cluster_499992 V1280738 TRMFO J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) COG1206 Cluster_529026 V1280739 GLGB map00500,map01100,map01110 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) COG0296 Cluster_715206 V1280740 P tonB-dependent siderophore receptor COG1629 Cluster_540333 V1280741 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_502506 V1280743 NUOL map00190,map00910,map01100 C NADH dehydrogenase subunit l COG1009 Cluster_502507 V1280744 FTSI map00550 M penicillin-binding protein COG0768 Cluster_502508 V1280746 LTAE map00260,map01100,map01110,map01120,map01230 E Aldolase COG2008 Cluster_762565 V1280747 S selenoprotein B, glycine betaine sarcosine D-proline reductase 123JW Cluster_657449 V1280748 PBUG S Xanthine uracil vitamin C permease COG2252 Cluster_549227 V1280749 G Major Facilitator COG2814 Cluster_557927 V1280750 COBW S cobw p47k family protein COG0523 Cluster_502509 V1280751 ASNA map00250,map00460,map00910,map01100,map01110,map01230 E asparagine synthetase A COG2502 Cluster_586245 V1280753 DEOD map00230,map00240,map00270,map00760,map01100,map01110 F purine nucleoside phosphorylase DeoD-type COG0813 Cluster_502511 V1280754 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_502512 V1280755 RTCR K regulatoR COG4650 Cluster_502513 V1280756 FTSK D cell division protein FtsK COG1674 Cluster_502514 V1280757 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_502515 V1280758 S NA 0XZ91 Cluster_537544 V1280759 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_637269 V1280760 K NA 0ZR1Z Cluster_725120 V1280761 PNCA map00760,map01100 Q nicotinamidase COG1335 Cluster_502516 V1280762 S Ragb susd domain-containing protein 0XQ8A Cluster_789513 V1280763 YQFL S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) COG1806 Cluster_758747 V1280764 PPDK map00620,map00680,map00710,map00720,map01100,map01120 G pyruvate phosphate dikinase COG0574 Cluster_738286 V1280765 CKL_1893 S Phage replisome organizer 11V35 Cluster_579810 V1280767 DNAC L DNA replication protein COG1484 Cluster_515375 V1280770 IDSA map00900,map01100,map01110 H Polyprenyl synthetase COG0142 Cluster_504901 V1280771 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_596403 V1280774 SCLAV_4550 L UPF0102 protein COG0792 Cluster_844401 V1280775 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_583050 V1280776 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase COG3959 Cluster_504902 V1280777 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_502517 V1280778 BCD map00071,map00280,map00281,map00650,map01100,map01110 I acyl-CoA dehydrogenase COG1960 Cluster_504903 V1280779 SPOIIE T stage ii sporulation protein e COG2208 Cluster_515376 V1280780 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_502518 V1280782 YGDL H uba thif-type nad fad binding protein COG1179 Cluster_502519 V1280783 S fad dependent oxidoreductase COG2509 Cluster_502520 V1280784 PGN_0048 S NA 0YI97 Cluster_637270 V1280785 CCHA E Microcompartments protein COG4577 Cluster_502521 V1280786 SUN J ribosomal RNA small subunit methyltransferase b COG0144 Cluster_529027 V1280787 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_504904 V1280788 YEHM S NA 173YR@proNOG Cluster_789514 V1280789 RPIA map00030,map00710,map01100,map01110,map01120,map01230 G phosphoriboisomerase A COG0120 Cluster_504905 V1280790 CAPD map00521,map00523,map01055,map01100,map01110 M Polysaccharide biosynthesis protein COG1086 Cluster_552118 V1280791 ATPC map00190,map00195,map01100 S Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) 11TPV Cluster_570242 V1280792 L Recombinase COG1961 Cluster_504906 V1280793 ASD map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) COG0136 Cluster_531868 V1280794 PLDB map00564 I alpha beta COG2267 Cluster_502522 V1280797 MURE map00300,map00550,map01100 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_657450 V1280801 S NA 11US4 Cluster_679002 V1280802 map00190,map00680,map01100 C ATP synthase, subunit F 124BE Cluster_504907 V1280803 S fibronectin type III domain protein 0XP4A Cluster_504908 V1280804 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_504909 V1280805 XSEA map03430 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 Cluster_504910 V1280810 FDNG map00630,map00680,map01100,map01120,map02020 C formate dehydrogenase alpha subunit COG0243 Cluster_504911 V1280811 PLDB map00564 I alpha beta COG2267 Cluster_502523 V1280812 C Thiol oxidoreductase COG3488 Cluster_502524 V1280813 PPDK map00620,map00710,map01100,map01120 G pyruvate phosphate dikinase COG0574 Cluster_504912 V1280814 HADH map00360,map00362,map00650,map01100,map01120 C Dehydrogenase COG1250 Cluster_507476 V1280816 NRDB map00230,map00240,map00480,map01100,map04115 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 Cluster_504913 V1280817 I Acyl-transferase COG1835 Cluster_502525 V1280818 M NA 11FBZ Cluster_534659 V1280820 DMPA E, Q peptidase s58 dmpa COG3191 Cluster_504914 V1280821 S NA 0ZG6A Cluster_603507 V1280824 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_641262 V1280825 NFO map03410 L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) COG0648 Cluster_504916 V1280827 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_504917 V1280828 S Membrane 11U5A Cluster_618248 V1280829 T cNMP 11GTE Cluster_773920 V1280831 C Flavodoxin COG0716 Cluster_549228 V1280833 AMYE map02010 G solute-binding protein COG1653 Cluster_653329 V1280834 GPO map00480,map00590 O Glutathione peroxidase COG0386 Cluster_504918 V1280838 PPDK map00620,map00710,map01100,map01120 G Pyruvate phosphate dikinase COG0574 Cluster_692428 V1280840 S peptidase M15 0Y4QW Cluster_504919 V1280841 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_504920 V1280842 MUTL map03430 L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) COG0323 Cluster_552119 V1280843 LGT M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 Cluster_840364 V1280844 KORB map00020,map00720,map01100,map01120 C 2-oxoglutarate ferredoxin oxidoreductase subunit beta COG1013 Cluster_504921 V1280845 S Rib/alpha-like repeat 10008 Cluster_537545 V1280847 WS0013 S membrAne 0XPGN Cluster_504922 V1280849 SERA map00260,map00270,map00680,map01100,map01120,map01230 E D-3-phosphoglycerate dehydrogenase COG0111 Cluster_507477 V1280850 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_699443 V1280851 P Rhodanese domain protein COG0607 Cluster_504923 V1280852 PYRF map00240,map01100 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) COG0284 Cluster_549229 V1280853 S NA 128C9 Cluster_504924 V1280854 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_504925 V1280855 S K05989 alpha-L-rhamnosidase EC 3.2.1.40 0XNWE Cluster_579811 V1280856 map02020 V ABC transporter, permease COG0577 Cluster_921799 V1280857 CCPA K Transcriptional regulator, LacI family COG1609 Cluster_555011 V1280858 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_504926 V1280859 MURE map00300,map00550,map01100 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 Cluster_507478 V1280860 DING map00230,map00240,map01100,map03030,map03430,map03440 L helicase COG2176 Cluster_586247 V1280861 S Gcn5-related n-acetyltransferase 11VJM Cluster_504927 V1280862 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_526266 V1280863 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_507479 V1280864 WECB map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_507480 V1280866 COBB map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_504929 V1280867 M Sulfatase COG1368 Cluster_560979 V1280868 K RNA Polymerase COG0086 Cluster_504930 V1280871 DEGV S degv family COG1307 Cluster_515377 V1280872 IDNO S gluconate 5-dehydrogenase 1729Z@proNOG Cluster_738288 V1280874 P Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) COG4206 Cluster_504931 V1280875 HSDM V type I restriction-modification system COG0286 Cluster_504932 V1280877 FTSW map04112 D cell division protein FtsW COG0772 Cluster_592931 V1280878 CELR K TRANSCRIPTIONal COG3711 Cluster_504933 V1280879 PGN_0950 V ABC transporter, ATP-binding protein COG1132 Cluster_770223 V1280880 S NA 0ZHU9 Cluster_670176 V1280882 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_504934 V1280885 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_507482 V1280887 DMPA E, Q peptidase s58 dmpa COG3191 Cluster_504935 V1280888 MAEB map00620,map00710,map01100,map01120 C Malic enzyme COG0281 Cluster_715208 V1280892 map03070 S NA 122A7 Cluster_649243 V1280893 HTRE map05133 M outer membrane usher protein COG3188 Cluster_552120 V1280895 RPSD map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) COG0522 Cluster_557929 V1280896 P ABC-type nitrate sulfonate bicarbonate transport COG0715 Cluster_570243 V1280897 YGIL S Fimbrial protein 17EBG@proNOG Cluster_741683 V1280898 S NA 0YKUS Cluster_507483 V1280899 YEGQ map05120 O Peptidase U32 COG0826 Cluster_510078 V1280900 NHAP P Potassium proton antiporter COG3263 Cluster_523354 V1280901 C domain protein COG0426 Cluster_507484 V1280903 CAPD map00051,map00362,map00363,map00521,map00523,map00591,map00625,map00626,map00650,map00903,map01055,map01100,map01110,map01120 M Polysaccharide biosynthesis protein COG1086 Cluster_888360 V1280905 S NA 0Y12S Cluster_653330 V1280906 S Protein of unknown function (DUF1524) COG1479 Cluster_589522 V1280907 PCCB map00280,map00630,map00640,map00720,map01100,map01120 M carboxyl transferase domain protein COG4799 Cluster_603508 V1280908 L Transposase COG3547 Cluster_504938 V1280909 ICTB M O-Antigen polymerase COG3307 Cluster_507485 V1280910 S NA 0Z34Z Cluster_507486 V1280911 GLTA map00020,map00630,map00640,map01100,map01110,map01120,map01210,map01230 C citrate synthase COG0372 Cluster_507487 V1280912 S NA 0YDXY Cluster_546200 V1280913 CITC map02020 C (citrate (pro-3S)-lyase ligase COG3053 Cluster_507488 V1280914 BMUL_5605 S VWA-like domain (DUF2201) 0XSQB Cluster_507489 V1280915 TRAA map03440 L mobA MobL family protein COG0507 Cluster_507490 V1280917 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_507491 V1280918 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_520615 V1280919 M Glycosyl transferase (Group 1 0XSCX Cluster_540334 V1280920 K Transcriptional regulator, ARAC family COG2207 Cluster_507492 V1280921 PPDK map00620,map00710,map01100,map01120 G pyruvate phosphate dikinase COG0574 Cluster_583051 V1280922 BT0173 S NA 0XNSZ Cluster_537546 V1280923 S abc transporter, permease COG1079 Cluster_504939 V1280924 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_755239 V1280926 P tonB-dependent Receptor 0XQJQ Cluster_507494 V1280927 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG2812 Cluster_670177 V1280930 FTSE map02010 D Cell division ATP-binding protein ftsE COG2884 Cluster_876288 V1280932 RPMF map03010 J 50s ribosomal protein l32 COG0333 Cluster_507495 V1280933 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_507496 V1280935 TELA P Resistance protein COG3853 Cluster_507497 V1280936 YHBJ S Displays ATPase and GTPase activities (By similarity) COG1660 Cluster_507498 V1280937 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_725121 V1280938 GADB map00250,map00410,map00430,map00650,map01100,map01110,map04727,map04940 E Glutamate decarboxylase COG0076 Cluster_507499 V1280939 YCGI U ATP-binding component of a transport system 16SGG@proNOG Cluster_529028 V1280947 MDMC map00340,map00350,map00360,map00624,map00940,map00941,map00945,map01100,map01110,map01120 S O-methyltransferase COG4122 Cluster_592932 V1280949 YICH S AsmA family 16RPE@proNOG Cluster_507504 V1280950 TRSE U traE protein COG3451 Cluster_507505 V1280951 CDR P pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_507506 V1280952 NTH map03410 L endonuclease III COG0177 Cluster_781431 V1280953 S NA 102GN Cluster_670178 V1280954 PANC map00410,map00770,map01100,map01110 H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) COG0414 Cluster_560980 V1280955 CIMA map00290,map01100,map01210,map01230 E synthase COG0119 Cluster_589523 V1280956 NQRB C na( )-translocating NADH-quinone reductase subunit b COG1805 Cluster_507507 V1280957 SURB S G5 domain protein 0ZVV3 Cluster_507508 V1280958 HTRA map03010 M peptidase S1 and S6, chymotrypsin Hap COG0265 Cluster_507509 V1280959 SELD map00450,map01100 E Synthesizes selenophosphate from selenide and ATP (By similarity) COG0709 Cluster_683577 V1280960 L integrase family COG0582 Cluster_855862 V1280961 S NA 11I9Q Cluster_696165 V1280962 DEF J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) COG0242 Cluster_507510 V1280963 L Dna topoisomerase COG0550 Cluster_599894 V1280964 G Major Facilitator COG2814 Cluster_557930 V1280965 S NA 0XRT7 Cluster_718470 V1280967 FTSI map00550 M penicillin-binding protein COG0768 Cluster_507511 V1280969 S NA 0YDFB Cluster_718471 V1280970 RLUC J Pseudouridine synthase COG0564 Cluster_670179 V1280971 L transposase COG3464 Cluster_507512 V1280972 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG3848 Cluster_534660 V1280973 map02010 V ABC-2 type transporter COG0842 Cluster_755240 V1280974 S cobw p47k family protein COG0523 Cluster_905234 V1280976 L Resolvase N-terminal domain protein 0YDPZ Cluster_510079 V1280979 SP_0324 map00052,map02060 G iic component COG3715 Cluster_537547 V1280980 S Signal transducer 1DM6V@verNOG Cluster_777613 V1280983 RFBA map00521,map00523,map01100,map01110 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) COG1209 Cluster_583052 V1280984 L Integrase core domain protein COG2801 Cluster_546201 V1280985 YHAO L DNA repair exonuclease COG0420 Cluster_507513 V1280986 DNAD L DNA replication protein DnaD COG3935 Cluster_599895 V1280989 GALE map00052,map00520,map01100,map01110 M udp-glucose 4-epimerase COG1087 Cluster_570244 V1280991 RDGB map00230,map00240,map01100 F Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) COG0127 Cluster_510080 V1280992 MGSA map00620 G methylglyoxal synthase COG1803 Cluster_510081 V1280993 U, W surface protein COG5295 Cluster_507514 V1280994 CSD1 L CRISPR-associated protein Csd1 family 0ZVNC Cluster_621890 V1280995 ARGR K Regulates arginine biosynthesis genes (By similarity) COG1438 Cluster_507515 V1280996 FIMD map05133 M outer membrane usher protein COG3188 Cluster_510082 V1280997 S Heparinase II/III-like protein 100DU Cluster_817164 V1280998 S Protein of unknown function (DUF3467) 11UAG Cluster_507516 V1280999 HCP map00910 C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) COG1151 Cluster_570245 V1281000 CBIO map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_537548 V1281001 S K05989 alpha-L-rhamnosidase EC 3.2.1.40 0XNWE Cluster_555012 V1281002 YCAN K LysR family Transcriptional regulator 16TEJ@proNOG Cluster_510083 V1281003 M group 2 family 0XRCB Cluster_510085 V1281006 S NA 121AE Cluster_510086 V1281007 FEOB P Ferrous iron transport protein B COG0370 Cluster_507517 V1281009 S NA 0XSVM Cluster_510087 V1281010 BMUL_2468 S Integrase 17D6W@proNOG Cluster_549230 V1281011 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_702477 V1281013 S NA 12D1F Cluster_510088 V1281014 S NA 0YDU4 Cluster_507518 V1281015 SRLD map00051,map00061,map00780,map01040,map01100 S reductase 0XNW1 Cluster_515378 V1281016 V abc transporter permease protein 0XQE2 Cluster_520616 V1281018 LIVF map02010 E ABC, transporter COG0410 Cluster_825022 V1281019 GNTP E, G Gluconate COG2610 Cluster_510092 V1281023 K (GntR family) (Transcriptional regulator COG2188 Cluster_510093 V1281025 EMRA map02020 V secretion protein, HlyD family COG1566 Cluster_913558 V1281026 S NA 0ZHU9 Cluster_734960 V1281030 GBRO_2584 L integrase family COG0582 Cluster_510095 V1281031 MREB D Rod shape-determining protein mreb COG1077 Cluster_510096 V1281033 METI map02010 P ABC transporter, permease COG2011 Cluster_510097 V1281034 SURB S G5 domain protein 0ZVV3 Cluster_510098 V1281035 SPR M nlp p60 protein COG0791 Cluster_510099 V1281036 PYKF map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG0469 Cluster_510100 V1281039 MT3797 S rdd domain containing protein COG1714 Cluster_507519 V1281040 GLGB map00500,map01100,map01110 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) COG0296 Cluster_510101 V1281042 ABPB map00310,map00780,map01100 E Dipeptidase COG4690 Cluster_510102 V1281043 FUSA2 J Translation elongation factor COG0480 Cluster_510104 V1281046 GYRA2 L DNA topoisomerase IV subunit A COG0188 Cluster_777614 V1281047 VORD map00020,map00720,map01100,map01120 C 4Fe-4S Ferredoxin, iron-sulfur binding domain protein COG1146 Cluster_510105 V1281049 U TraG family COG3505 Cluster_510106 V1281050 DUSB J Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_510107 V1281051 YCLM map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Aspartokinase COG0527 Cluster_661654 V1281052 L Replication initiator protein A 0Y2JJ Cluster_653331 V1281053 C domain protein COG0426 Cluster_510108 V1281054 L POLIIIAc COG2176 Cluster_629385 V1281055 L Transposase 11M0T Cluster_529030 V1281056 MRDB D Rod shape-determining protein rodA COG0772 Cluster_510109 V1281057 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_633212 V1281058 K Transcriptional regulator, GntR family COG1802 Cluster_546202 V1281059 SOV S Gliding motility-related protein 0XPT8 Cluster_621891 V1281060 PARB1 K parb-like partition protein COG1475 Cluster_653332 V1281061 V abc transporter atp-binding protein COG1131 Cluster_510110 V1281062 map00311,map00312,map01110,map02020 V Beta-lactamase COG2367 Cluster_576683 V1281063 map02010 V ABC transporter COG1131 Cluster_840365 V1281064 SCLAV_5203 S ABC transporter COG0488 Cluster_510111 V1281067 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_725123 V1281068 FIME K FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off COG0582 Cluster_738289 V1281069 YCHM P sulfate transporter COG0659 Cluster_512653 V1281070 XYLE map04113 G transporter 16TAE@proNOG Cluster_692429 V1281071 G hydrolase family 2, sugar binding COG3250 Cluster_510112 V1281072 map00040,map00500,map01100 S NA 11GMI Cluster_755241 V1281074 map03440 K transcriptional regulator containing an HTH domain and an COG2865 Cluster_512655 V1281075 UIDA map00040,map00500,map00531,map00860,map00944,map00983,map01100,map04142 G Beta-glucuronidase COG3250 Cluster_583053 V1281076 SP_1232 S Membrane COG4684 Cluster_512656 V1281077 S copper amine 121X1 Cluster_510113 V1281078 YCAM E amino acid COG0531 Cluster_510114 V1281080 APPA E Extracellular solute-binding protein, family 5 COG0747 Cluster_570246 V1281082 RPSK map03010 J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) COG0100 Cluster_510116 V1281083 V abc transporter permease protein COG0577 Cluster_510117 V1281084 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_512658 V1281086 PTSP map00051,map01100,map02060 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) COG1080 Cluster_546203 V1281088 map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020 C Flavocytochrome c COG1902 Cluster_510118 V1281089 SPR M nlp p60 protein COG0791 Cluster_512660 V1281091 C Binding Domain protein 0ZVNA Cluster_512661 V1281092 TATD L Hydrolase, tatD family COG0084 Cluster_579812 V1281095 S NA 0ZHVH Cluster_512662 V1281096 map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 G Glycosyl hydrolase family 20, catalytic domain protein COG3525 Cluster_512663 V1281097 OGT L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) COG0350 Cluster_825023 V1281098 YHFX E Racemase COG3457 Cluster_741684 V1281099 YHFT S transport system permease protein 174EM@proNOG Cluster_715209 V1281102 V (ABC) transporter 0XQRE Cluster_546204 V1281103 YNII S Zinc finger domain 0XNNM Cluster_705582 V1281105 K RNA polymerase COG1595 Cluster_872177 V1281106 YCIG S Stress-induced bacterial acidophilic repeat motif COG3729 Cluster_793311 V1281107 RPMC map03010 J 50s ribosomal protein l29 COG0255 Cluster_748339 V1281109 POTA map02010 E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COG3842 Cluster_512664 V1281110 P ABC-type nitrate sulfonate bicarbonate transport COG0715 Cluster_512665 V1281112 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_586248 V1281114 AMIA M n-acetylmuramoyl-l-alanine amidase COG0860 Cluster_832608 V1281115 HYAC C Ni Fe-hydrogenase, b-type cytochrome subunit COG1969 Cluster_512667 V1281116 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_692430 V1281117 map00620 C D-isomer specific 2-hydroxyacid dehydrogenase COG1052 Cluster_520617 V1281119 YLBB V abc transporter permease protein COG0577 Cluster_718473 V1281120 S fad dependent oxidoreductase COG2509 Cluster_512668 V1281121 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_512669 V1281122 FUSA2 J Translation elongation factor COG0480 Cluster_618249 V1281123 DNAG map03030 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 Cluster_625682 V1281124 map00190,map00910,map01100 C NADH dehydrogenase (Ubiquinone), 24 kDa subunit COG1905 Cluster_512670 V1281125 S radical SAM domain protein COG4277 Cluster_758749 V1281129 ATPF map00190,map00195,map01100 C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) COG0711 Cluster_755242 V1281132 S NA 0YK82 Cluster_512671 V1281133 YKUD M ErfK ybiS ycfS ynhG family protein COG1376 Cluster_610772 V1281134 RBO C Superoxide reductase COG2033 Cluster_789516 V1281135 TRAA map03440 L mobA MobL family protein COG0507 Cluster_512672 V1281137 PTSG map00010,map00500,map00520,map02060 G PTS System COG2190 Cluster_567156 V1281139 VPA1266 map03440 L Helicase, RecD TraA family COG0507 Cluster_560981 V1281140 LDH map00010,map00051,map00270,map00363,map00591,map00620,map00625,map00640,map00650,map01100,map01110,map01120 C Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) COG0039 Cluster_766516 V1281141 RSMI G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 Cluster_512673 V1281142 map02010 E ABC transporter, ATP-binding protein COG3839 Cluster_515379 V1281143 GSPE map03070 U type ii secretion system protein e COG2804 Cluster_512674 V1281144 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_876289 V1281145 YTQB map00340,map00350,map00624,map01120 Q rRNA Methylase COG0500 Cluster_657452 V1281146 WHIA K May be required for sporulation (By similarity) COG1481 Cluster_515380 V1281149 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 Cluster_512675 V1281150 POLB map00230,map00240,map01100 L DNA polymerase COG0417 Cluster_515381 V1281151 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_512676 V1281152 SURB S G5 domain protein 0ZVV3 Cluster_540335 V1281157 V type i restriction modification DNA specificity domain protein COG0732 Cluster_529031 V1281159 FECA P receptor COG4772 Cluster_512677 V1281160 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_515382 V1281161 YNII S Zinc finger domain 0XNNM Cluster_515383 V1281162 L Integrase core domain protein COG2801 Cluster_512678 V1281163 RRMA Q Methyltransferase COG0500 Cluster_515385 V1281165 COAX map00770,map01100 K Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) COG1521 Cluster_515386 V1281166 YHFX E Racemase COG3457 Cluster_512680 V1281168 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_512681 V1281169 V Mate efflux family protein COG0534 Cluster_512682 V1281170 S ABC transporter 124C1 Cluster_515387 V1281171 GCVPA map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG0403 Cluster_515388 V1281172 S Conserved repeat 118QN Cluster_512683 V1281173 PITRM1 O peptidase COG1026 Cluster_821057 V1281175 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG0194 Cluster_728447 V1281176 RPOZ map00230,map00240,map01100,map03020 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) COG1758 Cluster_515389 V1281179 S Inherit from COG: Toxin-antitoxin system, toxin component, Fic family COG3943 Cluster_512684 V1281180 S Listeria-Bacteroides repeat domain (List_Bact_rpt) 0YG1D Cluster_696167 V1281182 RNY S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 Cluster_610773 V1281183 S n-acetylglucosamine 0ZDER Cluster_549231 V1281186 S filamentation induced by cAMP protein Fic COG3177 Cluster_515391 V1281187 FTSK D cell division protein FtsK COG1674 Cluster_852084 V1281188 MAF D Maf-like protein COG0424 Cluster_721772 V1281189 DAPD map00300,map01100,map01120,map01230 E Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) COG2171 Cluster_515392 V1281190 OPPA map02010 E Extracellular solute-binding protein, family 5 COG4166 Cluster_515393 V1281191 DINB L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII (By similarity) COG0389 Cluster_557931 V1281193 YDJG S Zinc finger domain 0XNNM Cluster_618250 V1281194 SCLAV_1660 K RNA Polymerase COG1595 Cluster_515394 V1281195 LPXA map00540,map01100 M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) COG1043 Cluster_576684 V1281196 GLYA map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01230 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) COG0112 Cluster_512685 V1281197 BMUL_5920 S Rhomboid family COG0705 Cluster_512686 V1281198 S NA 0XRT7 Cluster_512687 V1281199 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_546205 V1281202 S domain protein 12C1H Cluster_518032 V1281204 SITC map02010,map02020 P ABC transporter COG1108 Cluster_515396 V1281206 ARCA map00330,map01100,map01110 E Arginine dihydrolase COG2235 Cluster_515397 V1281207 S NA 0XQ6D Cluster_515398 V1281208 PM0594 S Protein of unknown function DUF262 COG1479 Cluster_515399 V1281209 SSCG_04455 S Methyltransferase 0XSGP Cluster_715210 V1281210 FUCA map00051,map00053,map01100,map01120 G Aldolase COG0235 Cluster_549232 V1281211 F Permease family COG2233 Cluster_688007 V1281212 AATB map02010 E ABC transporter substrate-binding protein COG0834 Cluster_683578 V1281215 DPPB P Binding-protein-dependent transport system inner membrane component COG0601 Cluster_589525 V1281217 TGT J Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COG0343 Cluster_817167 V1281219 HTPG map04141,map04151,map04612,map04621,map04626,map04914,map04915,map05200,map05215 O Molecular chaperone. Has ATPase activity (By similarity) COG0326 Cluster_515400 V1281220 ASLA1 map00531,map01100,map04142 P Arylsulfatase COG3119 Cluster_515401 V1281222 LDTA S ErfK YbiS YcfS YnhG COG1376 Cluster_641264 V1281223 COBD map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01230 E decarboxylase COG0079 Cluster_821058 V1281225 V ABC transporter, permease protein 0XP9H Cluster_797277 V1281226 V ABC transporter, permease protein 0XP9H Cluster_515403 V1281227 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_567157 V1281228 BL01171 P hemerythrin hhe cation binding domain protein COG2461 Cluster_515404 V1281229 TEX K domain protein COG2183 Cluster_515405 V1281230 AROA map00400,map01100,map01110,map01230 E 3-phosphoshikimate 1-carboxyvinyltransferase COG0128 Cluster_781434 V1281231 YAAA L UPF0246 protein COG3022 Cluster_518033 V1281233 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01230 G phosphohexose isomerase COG0166 Cluster_515406 V1281234 HSDS V Restriction modification system DNA (Specificity COG0732 Cluster_515407 V1281235 NIFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_734961 V1281236 S NA 11XM2 Cluster_515408 V1281239 LRGB map02020 M lrgb family COG1346 Cluster_515409 V1281240 PHBA map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map02020 I acetyl-CoA COG0183 Cluster_557932 V1281241 P faD-dependent pyridine nucleotide-disulfide oxidoreductase COG0607 Cluster_653333 V1281244 YGIN S Antibiotic biosynthesis monooxygenase COG1359 Cluster_518035 V1281245 S Pfam:YadA 0ZHSU Cluster_570247 V1281246 CCMA V ABC transporter COG1131 Cluster_515410 V1281247 RECG map03440 L ATP-dependent DNA helicase recG COG1200 Cluster_515411 V1281248 STP T Phosphatase COG0631 Cluster_633213 V1281250 map04112 M Peptidase family M50 COG0750 Cluster_665865 V1281251 O aaa atpase central domain protein COG0464 Cluster_515412 V1281252 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_515413 V1281254 T Y_Y_Y domain COG3706 Cluster_518036 V1281255 YIDE P transport protein COG2985 Cluster_518037 V1281256 C symporter COG1301 Cluster_515414 V1281257 ARSB P arsenicaL-resistance protein COG0798 Cluster_515415 V1281258 V N-6 DNA Methylase COG0286 Cluster_599896 V1281259 L DEAD DEAH box helicase COG1201 Cluster_515416 V1281260 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_744993 V1281261 PYRE map00240,map01100 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 Cluster_518038 V1281262 V ABC transporter COG1136 Cluster_696168 V1281263 S NA 0YMAD Cluster_625683 V1281264 S Protein of unknown function (DUF3575) 0Y9VZ Cluster_518039 V1281267 BH0416 L Transposase COG3464 Cluster_518040 V1281268 M cell wall-binding protein COG2247 Cluster_777615 V1281270 PTSH G HPr family COG1925 Cluster_520618 V1281271 MSCS M mechanosensitive ion channel COG0668 Cluster_610774 V1281272 V ABC transporter, permease COG0577 Cluster_809439 V1281273 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_518041 V1281276 S Rib/alpha-like repeat 0YK85 Cluster_515417 V1281278 HP1117 S Sel1 domain protein repeat-containing protein COG0790 Cluster_515418 V1281279 YCCC map00250,map00330,map00460,map00471,map00910,map01100,map01110,map01120,map02020 E L-asparaginase COG0252 Cluster_741685 V1281280 PAAG map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120 Q EnoyL-CoA hydratase COG1024 Cluster_813437 V1281281 PAAH map00360,map00362,map00650,map01100,map01120 I 3-hydroxyacyl-coa dehydrogenase COG1250 Cluster_518043 V1281282 PEPP E peptidase, M24 COG0006 Cluster_518044 V1281284 PLAV_1177 L DNA methylase n-4 n-6 domain protein 0XQ84 Cluster_518045 V1281287 U TraG family COG3505 Cluster_518046 V1281288 CSD1 L CRISPR-associated protein Csd1 family 0XPRM Cluster_621892 V1281289 LIVJ map02010 E Amino Acid ABC COG0683 Cluster_793312 V1281290 YIBT S LF82 chromosome, complete sequence 17QWT@proNOG Cluster_641265 V1281292 S filamentation induced by cAMP protein Fic COG3177 Cluster_515419 V1281294 CINA H competence damage-inducible protein COG1546 Cluster_603509 V1281295 S (LipO)protein 0XQ9B Cluster_748341 V1281296 YEBC K transcriptional regulatory protein COG0217 Cluster_573476 V1281297 M exopolysaccharide biosynthesis COG0489 Cluster_718474 V1281298 L NA 11GDS Cluster_518047 V1281299 E Peptidase, S9A B C family, catalytic domain protein COG1506 Cluster_534661 V1281300 S filamentation induced by cAMP protein fic COG3177 Cluster_518049 V1281302 map00051,map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 G Glycosyl hydrolase family 20 COG3525 Cluster_518050 V1281303 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_523355 V1281304 YCLM map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Aspartokinase COG0527 Cluster_633214 V1281306 BL00603 S Protein of unknown function (DUF2089) 125WH Cluster_576685 V1281307 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_748342 V1281309 J Ribonuclease COG1530 Cluster_523356 V1281310 CADA P p-type atpase COG2217 Cluster_518051 V1281311 S NA 11FEM Cluster_518052 V1281312 S (phospho)adenosine phosphosulfate reductase 11QGN Cluster_762568 V1281314 map00010,map00500 G glycoside hydrolase family 4 COG1486 Cluster_518053 V1281317 DEOD map00230,map00240,map00270,map00760,map01100,map01110 F purine nucleoside phosphorylase DeoD-type COG0813 Cluster_518054 V1281319 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0587 Cluster_674567 V1281320 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_708655 V1281321 S NA 0ZHU9 Cluster_518055 V1281322 F ATP cone domain COG1328 Cluster_518056 V1281323 S phage Tail Protein 0Z1N7 Cluster_518058 V1281328 S amidinotransferase COG4874 Cluster_518059 V1281329 K RNA Polymerase 11YW1 Cluster_518060 V1281330 map00564,map00730 C fad dependent oxidoreductase COG0579 Cluster_552121 V1281332 MNME S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 Cluster_518061 V1281333 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_518062 V1281334 GLNP map02010 E amino acid AbC transporter COG0765 Cluster_649244 V1281336 FLGJ map00511 N, U flagellar rod assembly protein muramidase flgj COG1705 Cluster_523357 V1281337 S tetratricopeptide 0ZVCF Cluster_614491 V1281338 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_518064 V1281340 E, G Gluconate COG2610 Cluster_731712 V1281341 YAFO T this blockage is overcome by subsequent expression of antitoxin YafN. Overexpression causes cleavage of a number of mRNAs in a ribosome-dependent fashion. YafO binding to the 50S ribosomal subunit in the translation complex induces mRNA cleavage 3' to the region protected by the ribosome 17Q9G@proNOG Cluster_828810 V1281342 YAFN D Antitoxin of the YafO-YafN toxin-antitoxin system COG2161 Cluster_633215 V1281343 map00770 S 4'-phosphopantetheinyl transferase 0XPB1 Cluster_518065 V1281344 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_529032 V1281345 IOLH G myo-inositol catabolism protein COG1082 Cluster_540338 V1281346 CLCAR_1980 P iron permease, FTR1 COG0672 Cluster_520620 V1281347 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_520621 V1281348 AST S Enterotoxin 0YVWS Cluster_520622 V1281349 O glycyl-radical enzyme activating protein family COG1180 Cluster_520624 V1281352 V Efflux ABC transporter, permease protein 0ZZXU Cluster_520625 V1281353 H MMPL domain protein COG2409 Cluster_728448 V1281354 S NA 0XTN2 Cluster_583054 V1281358 NNRD G Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) COG0063 Cluster_721773 V1281360 S NA 0XWEM Cluster_518066 V1281361 ASPB map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aminotransferase COG0436 Cluster_520626 V1281362 TREB map00010,map00500,map00520,map02060 G phosphotransferase system, EIIB COG1264 Cluster_520627 V1281363 S conjugation system ATPase, TraG family 0XSHU Cluster_711852 V1281367 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_696169 V1281368 XPT map00230,map01100,map01110 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) COG0503 Cluster_518067 V1281369 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_579814 V1281371 YLBM S UPF0348 protein COG1323 Cluster_520628 V1281372 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L POLAc COG0749 Cluster_579815 V1281373 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_520629 V1281374 ASPC map00250,map00290,map01100,map01110,map01210,map01230 E Aminotransferase COG0436 Cluster_520630 V1281375 P tonB-dependent receptor plug 0XSMW Cluster_855864 V1281376 S NA 0YDRM Cluster_809441 V1281377 S NA 0XTZN Cluster_793313 V1281378 S NA 129EW Cluster_520631 V1281379 S NA 1221V Cluster_641266 V1281380 NANH map00520 E, M N-acetylneuraminate lyase COG0329 Cluster_607120 V1281381 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_699445 V1281382 S Initiator RepB protein 0YDN3 Cluster_599897 V1281383 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Phosphoribosyl pyrophosphate synthase COG0462 Cluster_520632 V1281384 map01054 Q Phosphopantetheine attachment site COG3321 Cluster_603510 V1281385 C Flavodoxin COG0716 Cluster_520633 V1281386 PULA map00500,map01100,map04973 G pullulanase COG1523 Cluster_793314 V1281387 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_520634 V1281390 S fibronectin type III domain protein 0XP4A Cluster_520635 V1281391 S Ragb susd domain-containing protein 0XSTW Cluster_520636 V1281392 ACDA map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I Acyl-coA dehydrogenase COG2025 Cluster_518069 V1281393 L Reverse transcriptase COG3344 Cluster_520637 V1281394 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_679004 V1281396 ISPB map00900,map01110 H synthase COG0142 Cluster_708656 V1281398 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_520638 V1281399 YLBB V abc transporter permease protein COG0577 Cluster_520639 V1281401 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_520640 V1281403 map00051,map00520,map01100,map02060 G pts system mannose fructose sorbose family iid COG3716 Cluster_520641 V1281404 LGAS_0606 S Phage Portal Protein 0XP33 Cluster_864221 V1281405 RUBR C rubredoxin COG1773 Cluster_520642 V1281406 POTD map02010 E ABC transporter COG0687 Cluster_599898 V1281410 CLVE map02010 S NA 11PT3 Cluster_688008 V1281411 E, P ABC transporter COG0444 Cluster_728449 V1281412 NAGA map00052,map00520,map01110 G GlcNAc 6-P deacetylase COG1820 Cluster_589526 V1281413 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_520643 V1281414 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_520644 V1281415 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_586249 V1281416 ARGF map00330,map01100,map01110,map01230 E ornithine carbamoyltransferase COG0078 Cluster_520645 V1281417 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_777617 V1281418 S Membrane COG2035 Cluster_520646 V1281419 YQEV J MiaB-like tRNA modifying enzyme COG0621 Cluster_520647 V1281420 S repeat protein COG0457 Cluster_708657 V1281421 S Protein of unknown function DUF86 1260Z Cluster_913561 V1281422 K transcriptional regulator with C-terminal CBS domains 0XUC3 Cluster_692433 V1281423 S TIM-barrel fold 11FGY Cluster_758750 V1281424 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_520648 V1281425 ISCU C SUF system FeS assembly protein, NifU family COG0822 Cluster_728450 V1281426 S domain protein COG0673 Cluster_552122 V1281427 S F420-0:Gamma-glutamyl ligase 0Y085 Cluster_520649 V1281428 GATB map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 Cluster_603511 V1281432 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_526269 V1281434 O DnaJ domain protein COG0484 Cluster_523358 V1281435 FUSA2 T elongation factor G COG0480 Cluster_520652 V1281438 TATD L Hydrolase, tatD family COG0084 Cluster_592933 V1281439 map02010 G NA 10Q7N Cluster_661658 V1281440 map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) COG1156 Cluster_523359 V1281444 NPDA map00520,map01100,map01110 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 Cluster_621893 V1281447 S Pfam:DUF477 0ZX30 Cluster_607121 V1281448 S TIM-barrel fold 11FGY Cluster_734962 V1281449 THID map00730,map01100 H phosphomethylpyrimidine kinase COG0351 Cluster_836429 V1281450 S NA 17232@proNOG Cluster_520655 V1281451 S NA 11F3W Cluster_523360 V1281452 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_537549 V1281456 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_552123 V1281462 S NA 11F3W Cluster_523364 V1281463 CCL S Membrane COG4708 Cluster_523365 V1281464 S NA 125J8 Cluster_520656 V1281465 P MgtE intracellular region COG2239 Cluster_633216 V1281467 YIHY S ribonuclease BN COG1295 Cluster_520657 V1281468 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG2812 Cluster_520658 V1281469 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_520659 V1281470 SIGB K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG1191 Cluster_576686 V1281471 T stage II sporulation protein 11QTH Cluster_523366 V1281472 S domain protein 0XPXI Cluster_520660 V1281473 CAFA map03018 J ribonuclease COG1530 Cluster_523367 V1281474 map00280,map00362,map00650,map01100,map01120 I glutaconyl-CoA decarboxylase COG4799 Cluster_523368 V1281475 P Transporter COG1292 Cluster_844404 V1281476 FDXA C Ferredoxin COG1145 Cluster_828811 V1281477 DMPA E, Q peptidase s58 dmpa COG3191 Cluster_523369 V1281478 TRMD map00900,map01100,map01110 J Specifically methylates guanosine-37 in various tRNAs (By similarity) COG0336 Cluster_621894 V1281479 S NA 18424@proNOG Cluster_523370 V1281480 LGAS_0621 S Phage cell wall hydrolase 0XSRY Cluster_633217 V1281481 APEA map00480,map01100 E M18 family aminopeptidase COG1362 Cluster_523371 V1281482 S GH3 auxin-responsive promoter 0ZVFE Cluster_755244 V1281483 S NA 0XPGY Cluster_789518 V1281484 S NA 11NCU Cluster_734963 V1281485 S NA 0Z1HW Cluster_520661 V1281486 S Inherit from COG: pyridine nucleotide-disulfide oxidoreductase COG2210 Cluster_813439 V1281487 RSFS S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) COG0799 Cluster_523372 V1281489 RIBD map00740,map01100 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) COG1985 Cluster_523373 V1281490 PPSA S pyruvate phosphate dikinase 0XRDW Cluster_523374 V1281491 GLPB map00564 E anaerobic glycerol-3-phosphate dehydrogenase, subunit B COG3075 Cluster_573477 V1281492 G Major Facilitator COG0477 Cluster_653334 V1281494 OLIA S Oligopeptide transporter, Opt family COG1297 Cluster_618251 V1281495 G Major Facilitator COG0477 Cluster_523375 V1281497 TOGM map02010 P binding-protein-dependent transport systems inner membrane component COG1175 Cluster_696170 V1281499 YLME F alanine racemase domain protein COG0325 Cluster_583055 V1281500 KORA map00020,map00720,map01100,map01120 C 2-oxoacid acceptor oxidoreductase, alpha subunit COG1014 Cluster_665866 V1281502 GPPA map00230 F, P ppx gppa phosphatase COG0248 Cluster_567158 V1281503 NHAA map00680 P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) COG3004 Cluster_523376 V1281505 P TonB-dependent Receptor Plug 0XRHT Cluster_523377 V1281506 PG0188 S BNR Asp-box repeat protein 11U9Y Cluster_607122 V1281511 TRKH P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) COG0168 Cluster_523378 V1281512 ACDA map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I Acyl-coA dehydrogenase COG2025 Cluster_523379 V1281513 S Domain of unknown function (DUF2088) COG3875 Cluster_741686 V1281514 YQJH P Siderophore-interacting protein COG2375 Cluster_523380 V1281516 THIE map00730,map01100 H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) COG0352 Cluster_523381 V1281517 GLNE O, T Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) COG1391 Cluster_523382 V1281518 L DNA gyrase COG0187 Cluster_523383 V1281519 SAGE S CAAX amino terminal protease family 0XUJM Cluster_781438 V1281521 ACCB map00061,map00253,map00620,map00640,map00720,map01100,map01110,map01120 I Acetyl-CoA carboxylase, biotin carboxyl carrier protein COG0511 Cluster_523384 V1281522 RSGA G May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) COG1162 Cluster_607123 V1281523 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_748344 V1281524 FABH map00061,map01100 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) COG0332 Cluster_534662 V1281525 P Chromate transport protein COG2059 Cluster_755246 V1281526 S NA 11V19 Cluster_773922 V1281527 ABGA E amidohydrolase COG1473 Cluster_523385 V1281528 SDHA map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map05134 C Succinate dehydrogenase (Flavoprotein subunit) COG1053 Cluster_523386 V1281529 NAGA map00520,map01110 G GlcNAc 6-P deacetylase COG1820 Cluster_523387 V1281530 S NA 101UU Cluster_523389 V1281534 I CoA enzyme activase uncharacterised domain (DUF2229) COG3581 Cluster_523390 V1281535 TDH G, M epimerase dehydratase COG0451 Cluster_576687 V1281536 M Cell wall anchor domain protein 129AF Cluster_526270 V1281538 DCM map00270,map01100 L cytosine-specific methyltransferase COG0270 Cluster_576688 V1281542 TRKH P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) COG0168 Cluster_621895 V1281543 LRGA map02020 S lrga family COG1380 Cluster_526271 V1281544 S ErfK YbiS YcfS YnhG COG1376 Cluster_523391 V1281545 S NA 11IME Cluster_679005 V1281547 BIOB map00780,map01100 H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) COG0502 Cluster_523392 V1281548 ETFA map00910 C Electron transfer flavoprotein COG2025 Cluster_621896 V1281549 POTD map02010 E ABC transporter COG0687 Cluster_523393 V1281550 BL01171 P hemerythrin hhe cation binding domain protein COG2461 Cluster_744994 V1281551 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_789519 V1281553 SSCG_03030 map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_755247 V1281554 S NA 0YWBS Cluster_523394 V1281555 THIM map00730,map01100 H 4-methyl-5-beta-hydroxyethylthiazole kinase COG2145 Cluster_523395 V1281556 ASRA C Sulfite reductase, subunit A COG1145 Cluster_531869 V1281557 YCHF J gtp-binding protein COG0012 Cluster_523396 V1281558 V Abc transporter COG1132 Cluster_905238 V1281560 K transcriptional regulator MERR family 11QIE Cluster_821059 V1281561 APEA map00480,map01100 E M18 family aminopeptidase COG1362 Cluster_523397 V1281562 MGTA P magnesium-translocating p-type atpase COG0474 Cluster_725124 V1281563 OPPB map02010 P Oligopeptide transporter permease COG0601 Cluster_526272 V1281564 S NA 0ZVJP Cluster_523398 V1281565 S Abortive infection protein 11JRG Cluster_744995 V1281566 S NA 0YDTJ Cluster_844406 V1281567 S transposon TraJ 0YBFN Cluster_523400 V1281572 S NA 0Z3UP Cluster_523401 V1281573 TRKA P potassium transporter peripheral membrane COG0569 Cluster_523402 V1281574 INSK L Transposase COG2801 Cluster_526273 V1281575 PAAG I Enoyl-CoA hydratase COG1024 Cluster_589527 V1281576 S NA 0ZW2D Cluster_549233 V1281577 O Peptidase, M16 COG0612 Cluster_523404 V1281579 FRPC O hemolysin-type calcium-binding region COG2931 Cluster_781439 V1281580 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_596404 V1281582 L Reverse transcriptase COG3344 Cluster_781440 V1281583 S NA 0Y0MT Cluster_683579 V1281584 MSMX map02010 G ABC transporter, ATP-binding protein COG3839 Cluster_526274 V1281586 WCFS map00051 M Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase COG2148 Cluster_573479 V1281587 FCL map00051,map00520,map01100 M Nad-dependent epimerase dehydratase COG0451 Cluster_523405 V1281589 S NA 0ZTYV Cluster_526275 V1281591 ACEA map00630,map01100,map01120 C Isocitrate lyase COG2224 Cluster_523407 V1281594 YTQB map00340,map00350,map00624,map01120 Q rRNA Methylase COG0500 Cluster_583056 V1281595 MRAY map00550,map01100 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) COG0472 Cluster_523408 V1281598 K transcriptional regulator, IclR family COG1414 Cluster_523409 V1281599 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_821061 V1281600 OCAR_5156 E transglutaminase domain protein COG1305 Cluster_526277 V1281603 map02010 S NA 0XSAQ Cluster_526278 V1281604 Q Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) COG1020 Cluster_523410 V1281605 SCPA S Segregation and condensation protein COG1354 Cluster_523411 V1281606 ARSA map00600,map04142 P Arylsulfatase COG3119 Cluster_674568 V1281609 S phage plasmid primase, p4 family COG3378 Cluster_657453 V1281610 PRFC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) COG4108 Cluster_523412 V1281611 GLGB map00500,map01100,map01110 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) COG0296 Cluster_755248 V1281612 S NA 11YHK Cluster_596405 V1281614 GLDA map02010 V ABC, transporter COG1131 Cluster_523413 V1281615 PLDB map00561,map00564,map01100,map04723 I Alpha Beta Hydrolase Fold protein COG2267 Cluster_523414 V1281616 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_589528 V1281617 L integrase family 0XRS7 Cluster_526279 V1281618 COBS map00860,map01100 H Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) COG0368 Cluster_523415 V1281619 AAPQ map02010 E amino acid ABC transporter COG4597 Cluster_526280 V1281620 SURE map00230,map00240,map00760,map01100,map01110 F Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) COG0496 Cluster_526281 V1281621 M glycosyltransferase group 2 family protein COG0463 Cluster_744996 V1281623 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_526284 V1281625 SODC map04146,map05014,map05016,map05020 P Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) COG2032 Cluster_570249 V1281628 BMUL_5605 S VWA-like domain (DUF2201) 0XSQB Cluster_583057 V1281629 K Transcriptional regulator, ARAC family COG2207 Cluster_526287 V1281632 NIFJ map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map00910,map01100,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_534663 V1281634 M domain protein 11R9X Cluster_629387 V1281635 S Protein of unknown function (DUF1113) COG4905 Cluster_618252 V1281636 S Uncharacterised ACR, YkgG family COG1556 0ZXQV Cluster_526288 V1281637 GLCD map00620,map00630,map01100,map01110,map01120 C glycolate oxidase COG0277 Cluster_526289 V1281638 M polysaccharide biosynthesis protein COG2244 Cluster_741687 V1281639 TXE S Addiction module toxin, Txe YoeB family COG4115 Cluster_821062 V1281640 L Addiction module antitoxin, RelB DinJ family 122EC Cluster_526290 V1281641 MSCS M mechanosensitive ion channel COG0668 Cluster_526291 V1281642 YACL S PilT protein domain protein COG4956 Cluster_526293 V1281644 S NA 0XRGD Cluster_661660 V1281645 RECR map03440 L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) COG0353 Cluster_526294 V1281646 UXAC map00040,map01100 G Uronic isomerase COG1904 Cluster_526295 V1281647 S domain protein 0ZZY0 Cluster_526296 V1281648 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_526297 V1281649 S PBPb 11IU5 Cluster_526298 V1281650 YIAN G transporter COG1593 Cluster_526299 V1281651 MEXF V AcrB AcrD family multidrug resistance protein COG0841 Cluster_526300 V1281652 GLYQS map00970 J Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) COG0423 Cluster_526301 V1281653 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_529033 V1281655 S NA 11Y61 Cluster_526302 V1281657 HYPB K, O Hydrogenase accessory protein HypB COG0378 Cluster_529034 V1281658 P solute-binding protein COG1840 Cluster_900942 V1281659 OMPC map02020 M Membrane COG3203 Cluster_649245 V1281661 HYAB map00633,map01120 C Hydrogenase, large subunit COG0374 Cluster_557934 V1281663 S NA 101GK Cluster_526303 V1281664 PFLA O Pyruvate formate-lyase COG1882 Cluster_526304 V1281665 DAPE map00300,map00330,map01100,map01110,map01120,map01210,map01230 E Acetylornithine deacetylase COG0624 Cluster_589529 V1281666 map00340,map00350,map00624,map01120 L Methyltransferase COG0742 Cluster_526305 V1281668 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_526306 V1281669 S Inherit from COG: ATPase (AAA COG1373 Cluster_526307 V1281672 M domain protein COG4932 Cluster_529036 V1281674 DCP E oligopeptidase A COG0339 Cluster_573480 V1281675 FRVX map00500,map01100 E Peptidase m42 family protein COG1363 Cluster_526308 V1281676 S Endonuclease Exonuclease phosphatase 11EFS Cluster_614495 V1281677 GLTS E Sodium Glutamate Symporter COG0786 Cluster_526309 V1281679 RNFC C Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) COG4656 Cluster_529037 V1281680 COBM map00860,map01100 H precorrin-4 C(11)-methyltransferase COG2875 Cluster_526310 V1281682 ENTB map01053,map01110 Q isochorismatase COG3433 Cluster_725125 V1281685 CLPC O ATP-dependent Clp protease, ATP-binding subunit ClpC COG0542 Cluster_599900 V1281686 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_526312 V1281687 PRDF map00330,map01100 E Proline racemase COG3938 Cluster_529038 V1281688 RIBH map00740,map01100 H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) COG0054 Cluster_555013 V1281689 map00052,map00511,map00600,map01100 G beta-galactosidase COG1874 Cluster_529039 V1281690 ASPC map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01210,map01230 E Aminotransferase class I and II COG0436 Cluster_773923 V1281691 MALR map00473,map01100 K transcriptional regulator COG1609 Cluster_526313 V1281692 V ABC transporter COG1132 Cluster_529040 V1281693 BDP_1102 V ABC transporter, ATP-binding protein COG1136 Cluster_529041 V1281694 map00190,map00910,map01100 C hydrogenase) (Fe-only COG4624 Cluster_529042 V1281697 ACTP P p-type ATPase COG2217 Cluster_526314 V1281699 RNHA map03030 S ribonuclease COG3341 Cluster_526315 V1281701 S Relaxase mobilization nuclease 16R4M@proNOG Cluster_529044 V1281702 D domain protein 0XTIC Cluster_529045 V1281703 CYSK map00270,map00920,map01100,map01120,map01230 E Cysteine synthase COG0031 Cluster_529047 V1281705 ISCS map00730,map04122 E Cysteine desulfurase COG1104 Cluster_529048 V1281706 T Histidine kinase COG2197 Cluster_529049 V1281707 TNP L transposase COG3316 Cluster_741688 V1281709 NUOB map00190,map00910,map01100,map05010,map05012,map05016 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) COG0377 Cluster_529050 V1281710 S X-Pro dipeptidyl-peptidase (S15 family) 0ZJEE Cluster_529051 V1281711 YCF O cytochrome C COG0755 Cluster_586250 V1281712 RNHA map03030 S ribonuclease COG3341 Cluster_529052 V1281713 MT2607 map00330,map00480,map01100,map01110 E decarboxylase COG1982 Cluster_711853 V1281715 S excisionase 11NUM Cluster_549234 V1281716 TRPF map00400,map01100,map01110,map01230 E N-(5'-phosphoribosyl)anthranilate isomerase COG0135 Cluster_705583 V1281717 POTC map02010 P putrescine abc transporter COG1177 Cluster_721774 V1281719 NATA S (ABC) transporter COG4152 Cluster_855866 V1281720 NATB C, P ABC transporter, permease COG1668 Cluster_637273 V1281722 S NA 0Z9TE Cluster_670180 V1281724 TATD L Hydrolase, tatD family COG0084 Cluster_529055 V1281725 TNP3508A L Transposase COG3328 Cluster_529056 V1281726 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_529057 V1281727 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_529058 V1281728 S Uncharacterised protein family (UPF0104) 10F01 Cluster_570250 V1281729 S NA 0YAQ6 Cluster_537550 V1281731 G Major Facilitator 0XP2I Cluster_625687 V1281732 CWLD M n-acetylmuramoyl-l-alanine amidase COG0860 Cluster_529059 V1281733 APEB E M18 family aminopeptidase COG1362 Cluster_529060 V1281734 V ABC transporter COG1132 Cluster_529061 V1281735 O Fn3-like domain (DUF1034) COG1404 Cluster_744997 V1281738 BL00983 S Phage Portal Protein 11QNG Cluster_529062 V1281739 GLTA map00020,map00630,map00640,map01100,map01110,map01120,map01210,map01230 C citrate synthase COG0372 Cluster_649246 V1281740 map02020 T Histidine kinase COG0642 Cluster_529063 V1281742 RADC L DNA repair protein (RadC COG2003 Cluster_529064 V1281743 METTU_1963 L Transposase 0XRAH Cluster_529065 V1281744 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_529066 V1281745 EPSF M Glycosyl transferase (Group 1 COG0438 Cluster_621897 V1281746 S NA 11V19 Cluster_629388 V1281747 S NA 0XWEM Cluster_529067 V1281748 TNAA map00350,map00380 E tryptophanase EC 4.1.99.1 COG3033 Cluster_531870 V1281749 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_531871 V1281750 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_913566 V1281751 RFBB map00521,map00523,map01055,map01100,map01110 M dtdp-glucose 4,6-dehydratase COG1088 Cluster_529068 V1281752 map00360 E amidohydrolase COG1473 Cluster_665868 V1281754 LSPA map03060 M, U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) COG0597 Cluster_529069 V1281755 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G phosphohexokinase COG0205 Cluster_844409 V1281756 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_529070 V1281760 ECFT map02010 P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) COG0619 Cluster_529071 V1281761 CTPA M Carboxyl-terminal protease COG0793 Cluster_529072 V1281762 V abc transporter permease protein COG0577 Cluster_529073 V1281765 TREB map00010,map00500,map00520,map02060 G PTS system trehalose-specific transporter subunit IIBC COG1264 Cluster_702479 V1281766 T Serine Threonine protein kinase COG0515 Cluster_653336 V1281767 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_531872 V1281768 GSPE map03070 U type ii secretion system protein e COG2804 Cluster_529074 V1281769 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_531873 V1281770 AROA map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate synthase COG0128 Cluster_563956 V1281771 M Outer membrane protein, OMP85 family 0XNPU Cluster_531874 V1281772 GATB map00970,map01100 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 Cluster_529075 V1281774 M Inherit from COG: domain protein COG4932 Cluster_738291 V1281775 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_531876 V1281778 AROE map00400,map01100,map01110,map01230 E shikimate dehydrogenase COG0169 Cluster_699446 V1281779 GLPQ2 map00564 C glycerophosphoryl diester phosphodiesterase COG0584 Cluster_589530 V1281780 SCLAV_2513 map04112 L DNA Methylase COG0863 Cluster_531877 V1281781 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L POLAc COG0749 Cluster_531878 V1281782 YEII map00240 K pfkB family carbohydrate kinase COG2771 Cluster_793316 V1281784 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_828814 V1281788 RPMF map03010 J 50S ribosomal protein L32 COG0333 Cluster_529076 V1281789 map03440 K Transcriptional regulator 0XRI9 Cluster_563957 V1281790 S NA 12D1P Cluster_531879 V1281791 S SusD family 0XTI6 Cluster_705584 V1281792 YBAK S YbaK ebsC protein COG2606 Cluster_529077 V1281793 MAF D MAF-like protein COG0424 Cluster_534664 V1281794 S domain protein 0Y62D Cluster_531880 V1281795 PYRP F permease COG2233 Cluster_531881 V1281796 V Mate efflux family protein COG0534 Cluster_529078 V1281797 PDXK map00750,map01100 H Pyridoxal kinase COG2240 Cluster_653337 V1281798 THII map00730,map01100,map04122 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) COG0301 Cluster_621898 V1281800 REX K Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) COG2344 Cluster_835307 V1028002 MARR K MarR family Transcriptional regulator COG1846 Cluster_542280 V1028003 TAL map00010,map00030,map00500,map00520,map00710,map01051,map01100,map01110,map01120,map01230 G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) COG0176 Cluster_539572 V1028004 S NA 0ZTYV Cluster_780152 V1028005 P tonB-dependent Receptor 0XP2F Cluster_682201 V1028007 PFK map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G diphosphate--fructose-6-phosphate 1-phosphotransferase COG0205 Cluster_591875 V1028013 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_754200 V1028014 AMY map00500,map01100,map04973 G alpha-amylase COG0366 Cluster_585239 V1028016 GLUA map02010 E ABC transporter, ATP-binding protein COG1126 Cluster_542281 V1028017 POTA map02010 P ABC, transporter COG3842 Cluster_569278 V1028018 LPLT G Lysophospholipid transporter LplT 16UKC@proNOG Cluster_542282 V1028019 map00350,map00362,map00627,map00642,map00903,map01120 I acyltransferase 3 COG1835 Cluster_704650 V1028022 P chromate transporter COG2059 Cluster_539573 V1028024 PCD map00010,map00040,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00640,map00903,map01100,map01110,map01120 C Aldehyde dehydrogenase COG1012 Cluster_635939 V1028025 K Transcriptional regulator 172FI@proNOG Cluster_827755 V1028026 S cytosolic protein 0XSPM Cluster_799956 V1028027 S NA 11W01 Cluster_717524 V1028028 S NA 177GB@proNOG Cluster_542283 V1028029 map00230,map01100,map01110 S NA 12415 Cluster_740712 V1028032 YWFO S Phosphohydrolase COG1078 Cluster_854722 V1028033 YWFO S Phosphohydrolase COG1078 Cluster_542284 V1028034 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_542285 V1028036 YDJN S sodium dicarboxylate symporter COG1823 Cluster_542286 V1028039 CAIB C l-carnitine dehydratase bile acid-inducible protein F COG1804 Cluster_668889 V1028040 map03070 U conjugal transfer protein TrbG VirB9 CagX 18B7T@proNOG Cluster_542287 V1028042 S Nucleotidyl transferase of unknown function (DUF1814) 16RPC@proNOG Cluster_854723 V1028043 MSRA O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) COG0225 Cluster_542288 V1028045 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_613295 V1028046 K Transcriptional regulator COG3449 Cluster_542289 V1028047 RPFB L domain protein COG3583 Cluster_542290 V1028048 PHNB S Glyoxalase Bleomycin resistance protein (Dioxygenase COG2764 Cluster_542291 V1028049 MAA S maltose O-acetyltransferase COG0110 Cluster_733964 V1028050 S NA 11EHP Cluster_542292 V1028051 S Organic solvent tolerance protein 0XQ3B Cluster_542293 V1028052 PGL map00030,map01100,map01110,map01120 G 6-phosphogluconolactonase (EC 3.1.1.31) COG0363 Cluster_545263 V1028053 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_643923 V1028054 RUTR K TetR family transcriptional regulator COG1309 Cluster_643924 V1028055 S NA 0YT0X Cluster_743964 V1028056 T Diguanylate cyclase phosphodiesterase with pas pac 0XNMH Cluster_839062 V1028057 map02010 E amino acid ABC transporter, periplasmic 173V7@proNOG Cluster_591876 V1028060 S NA 178JD@proNOG Cluster_812273 V1028061 S glyoxalase bleomycin resistance protein dioxygenase 11Y37 Cluster_668890 V1028062 CUSB map02020 P Efflux transporter rnd family, mfp subunit 16QBP@proNOG Cluster_542294 V1028063 CAH map00910 P carbonic anhydrase COG3338 Cluster_695176 V1028064 RPLD map03010 J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) COG0088 Cluster_545264 V1028066 YFAS S alpha-2-macroglobulin domain protein COG2373 Cluster_591877 V1028068 CTAD map00190,map00910,map01100 C Cytochrome C oxidase, subunit I COG0843 Cluster_542295 V1028071 FAUA P Receptor COG4773 Cluster_569279 V1028072 YFHF M epimerase COG4276 Cluster_545266 V1028074 TRKH P Potassium uptake protein COG0168 Cluster_542296 V1028075 S Rib/alpha-like repeat 10008 Cluster_545267 V1028076 AAP map05150 M surface protein 0XSC2 Cluster_545268 V1028077 PSTA map02010 P phosphate ABC transporter, permease COG0581 Cluster_542297 V1028079 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_545270 V1028080 ELRF S cutinase 11FQ6 Cluster_545271 V1028081 NDH map00190 C NADH dehydrogenase COG1252 Cluster_750761 V1028083 M biosynthesis protein COG3206 Cluster_545272 V1028084 S Protein of unknown function (DUF3068) 0ZPTM Cluster_545273 V1028087 THIW S thiw protein COG4732 Cluster_698541 V1028088 YDIZ S Uncharacterized protein ydiZ 17HBN@proNOG Cluster_761377 V1028089 ACSA map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120 I amp-dependent synthetase and ligase COG0365 Cluster_551278 V1028091 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III, alpha subunit COG0587 Cluster_542298 V1028092 MCPU map02020,map02030 P methyl-accepting chemotaxis COG0840 Cluster_545274 V1028094 ACTP P p-type atpase COG2217 Cluster_624520 V1028095 FIMT U Fimbrial pilin related signal peptide protein COG4970 Cluster_730770 V1028098 S membrane protein, AbrB duplication COG3180 Cluster_545275 V1028099 BMUL_2090 S membrane COG1289 Cluster_545276 V1028100 S NA 17ZNH@proNOG Cluster_799957 V1028102 S helix-turn-helix domain protein 122WR Cluster_545278 V1028111 FTSK D cell division protein FtsK COG1674 Cluster_788424 V1028117 GLNE O, T Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) COG1391 Cluster_545279 V1028118 DEGS map02020 O peptidase S1 and S6, chymotrypsin Hap COG0265 Cluster_904062 V1028120 ADHA map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120 C alcohol dehydrogenase COG1064 Cluster_548306 V1028122 HSCC O Chaperone COG0443 Cluster_647935 V1028123 L zinc finger, CHC2-family protein COG0358 Cluster_548307 V1028124 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_656201 V1028127 map00071,map01100,map03320,map04146,map04920 I AMP-binding enzyme COG0318 Cluster_545280 V1028128 YRAP S Transport-associated protein COG2823 Cluster_548308 V1028133 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_698542 V1028134 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG1372 Cluster_545281 V1028141 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_660344 V1028146 D Cobyrinic acid ac-diamide synthase COG1192 Cluster_545282 V1028147 PUTA map00250,map00330,map01100,map01110 C Dehydrogenase COG1012 Cluster_937506 V1028148 YBHM S conserved inner membrane protein COG0670 Cluster_548311 V1028150 PCD map00010,map00040,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00640,map00903,map01100,map01110,map01120 C Aldehyde dehydrogenase COG1012 Cluster_591878 V1028151 RFE M Glycosyl transferase, family 4 COG0472 Cluster_548312 V1028152 YOCS S Bile acid COG0385 Cluster_548313 V1028155 S AFG1 family ATPase COG1485 Cluster_575691 V1028157 S NA 11U17 Cluster_548314 V1028158 CZCA P AcrB/AcrD/AcrF family COG3696 Cluster_548315 V1028160 BA_5405 S Membrane COG2855 Cluster_724185 V1028161 V ABC transporter COG1132 Cluster_548316 V1028162 ASNB map00250,map00910,map01100,map01110,map01120 E asparagine synthetase COG0367 Cluster_545283 V1028163 O Putative Ig domain COG4934 Cluster_695177 V1028165 map02010 P cobalt transport COG0619 Cluster_548317 V1028166 ADD map00230,map01100,map05340 F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) COG1816 Cluster_847197 V1028167 COBU map00860,map01100 H Adenosylcobinamide kinase COG2087 Cluster_835308 V1028168 COBQ map00860,map01100 H catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) COG1492 Cluster_548320 V1028172 L UvrD REP helicase COG1074 Cluster_750762 V1028173 KDPA map02020 P One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) COG2060 Cluster_916728 V1028175 F Purine nucleoside permease COG5042 Cluster_686585 V1028176 F Purine nucleoside permease COG5042 Cluster_548321 V1028177 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_548323 V1028179 map01053 Q non-ribosomal peptide synthetase COG1020 Cluster_548324 V1028180 G Major Facilitator 0XPHU Cluster_548327 V1028183 S NA 16S77@proNOG Cluster_631981 V1028185 T cyclic nucleotide-binding domain protein COG0664 Cluster_548328 V1028187 BGLA map00010 G Glycosyl hydrolase family 1 COG2723 Cluster_617017 V1028188 HUTG map00330,map00340,map01100 E formiminoglutamate hydrolase COG0010 Cluster_812274 V1028189 PTH J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) COG0193 Cluster_548329 V1028191 TNPB L integrase catalytic COG2801 Cluster_765355 V1028192 RLME J Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) COG0293 Cluster_548330 V1028195 S NA 0Z34Z Cluster_548331 V1028196 BKTB map00062,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map02020 I acetyL-CoA acetyltransferase COG0183 Cluster_531882 V1281801 GOR map00480 C reductase COG1249 Cluster_531883 V1281802 MALC map02010 P permease protein COG1175 Cluster_531884 V1281804 ACUB S (CBS) domain COG0517 Cluster_529079 V1281805 RIMO J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) COG0621 Cluster_531885 V1281808 S Terminase, large subunit 17DJ0@proNOG Cluster_868172 V1281809 RPSJ map03010 J Involved in the binding of tRNA to the ribosomes (By similarity) COG0051 Cluster_766518 V1281810 RPLC map03010 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 Cluster_529080 V1281812 YBIR P transporter COG0471 Cluster_610775 V1281813 S Membrane COG3949 Cluster_531886 V1281814 S domain protein 0XREF Cluster_670181 V1281815 S NA 0YCIZ Cluster_529081 V1281816 I Diacylglycerol kinase COG1597 Cluster_531887 V1281818 FLGE map02040 N flagellar hook protein, FlgE COG1749 Cluster_825026 V1281819 S Plasmid recombination enzyme 0XTDI Cluster_546206 V1281821 ANSA map00250,map00460,map00910,map01100,map01110 E L-asparaginase COG0252 Cluster_641267 V1281822 S NA 0Y3Q9 Cluster_531888 V1281823 HVST P sulfate transporter COG0659 Cluster_629389 V1281824 NHAC-1 map00680 C Na H antiporter COG1757 Cluster_531889 V1281825 ISPG map00900,map01100,map01110 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) COG0821 Cluster_785520 V1281826 O (Anaerobic) ribonucleoside-triphosphate reductase activating protein COG1180 Cluster_531890 V1281827 V Type II restriction endonuclease, Alw26I Eco31I Esp3I family 0YFNS Cluster_529082 V1281828 HRCA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) COG1420 Cluster_531891 V1281829 FADD15 map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG1022 Cluster_770224 V1281830 YEAN G Major Facilitator Superfamily COG2807 Cluster_531892 V1281831 PDXS map00750 H Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) COG0214 Cluster_529083 V1281832 AMACR C Alpha-methylacyl-CoA racemase COG1804 Cluster_531893 V1281833 ARTM map02010 E ABC, transporter COG4160 Cluster_789521 V1281834 ADK map00230,map00240,map01100,map01110 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 Cluster_607124 V1281835 GLYQ map00970 J glycyl-tRNA synthetase, alpha subunit COG0752 Cluster_880326 V1281838 T Histidine kinase COG0642 Cluster_755251 V1281839 RAIA J ribosomal subunit Interface protein COG1544 Cluster_531895 V1281840 S transporter gate domain protein 0XRV8 Cluster_531896 V1281841 S NA 1221V Cluster_537551 V1281842 MALQ map00500,map01100,map01110 G 4-alpha-glucanotransferase COG1640 Cluster_534665 V1281843 S NA 0ZWIA Cluster_531897 V1281845 map04974 E peptidase COG1506 Cluster_531898 V1281846 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_531899 V1281847 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_679006 V1281848 S Radical SAM superfamily COG0641 Cluster_531900 V1281849 S conserved domain protein 11Q3F Cluster_531901 V1281850 M domain protein COG4932 Cluster_531902 V1281851 L Pfam:Transposase_25 COG3436 Cluster_531904 V1281853 FTSW D cell cycle protein COG0772 Cluster_531905 V1281855 ILVI map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E Acetolactate synthase COG0028 Cluster_557935 V1281858 SPR M NLP P60 protein COG0791 Cluster_840369 V1281859 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_531907 V1281861 M polysaccharide deacetylase COG0726 Cluster_718476 V1281863 RDGB map00230,map00240,map01100 F Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) COG0127 Cluster_880327 V1281864 YHBY J Rna-binding protein COG1534 Cluster_592934 V1281865 L NUDIX domain 11W54 Cluster_629390 V1281867 HYDG map00730,map01100 H biosynthesis protein thiH COG1060 Cluster_688009 V1281868 H IA, variant 3 COG0637 Cluster_534667 V1281871 S NA 101UU Cluster_531908 V1281872 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_534668 V1281873 LEUA map00290,map00620,map01100,map01110,map01210,map01230 E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) COG0119 Cluster_531909 V1281874 SBCC L Exonuclease COG0419 Cluster_531910 V1281875 S NA 0YEJY Cluster_825027 V1281876 V ABC transporter, permease protein 11SWK Cluster_531911 V1281877 S NA 101UU Cluster_725126 V1281878 PRFA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) COG0216 Cluster_537552 V1281880 SERA2 map00260,map00680,map01100,map01120,map01230 E Dehydrogenase COG0111 Cluster_531912 V1281881 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_563958 V1281882 PHOB map02020 T regulator COG0745 Cluster_531913 V1281885 O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation (By similarity) COG0544 Cluster_537553 V1281886 GLNN map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG3968 Cluster_674569 V1281888 USP S CHAP domain protein COG3942 Cluster_534669 V1281889 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_770225 V1281890 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_699448 V1281893 ELAD O Protease that can act as an efficient and specific deubiquitinating enzyme in vitro. Does not possess desumoylating and deneddylating activities. The physiological substrate is 17QVE@proNOG Cluster_781441 V1281894 AACA7 S Catalyzes the transfer of an acetyl group from acetyl- CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring (By similarity) 11UUS Cluster_734965 V1281896 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_531915 V1281897 PBP2B map00550,map01100 M penicillin-binding protein COG0768 Cluster_825028 V1281898 G transporter 0XNQK Cluster_540339 V1281901 NPLT map00052,map00500,map01100,map04973 G alpha amylase, catalytic region COG0366 Cluster_766519 V1281902 S NA 0YHXM Cluster_534670 V1281903 ENC_44580 I Inherit from COG: Hemolysin-type calcium-binding COG4222 Cluster_534671 V1281904 GK0308 L Transposase COG3464 Cluster_725127 V1281905 RPLM map03010 J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) COG0102 Cluster_872179 V1281906 RPSI map03010 J 30S ribosomal protein S9 COG0103 Cluster_534672 V1281907 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_702481 V1281908 TRAG2 S conjugation system ATPase, TraG family 0XSHU Cluster_599902 V1281909 S SusD family 0XPTK Cluster_534673 V1281910 S conserved domain protein 11Q3F Cluster_534674 V1281911 ADDB L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination COG3857 Cluster_534675 V1281912 PARB K parb-like partition protein COG1475 Cluster_534676 V1281913 C radical SAM domain protein COG1032 Cluster_801255 V1281914 T Transcriptional regulator, ARAC family 0ZNCA Cluster_876292 V1281915 YEAO S MarR family Transcriptional regulator COG3189 Cluster_711854 V1281916 V Beta-lactamase COG1680 Cluster_531916 V1281918 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01230 G phosphohexose isomerase COG0166 Cluster_589531 V1281919 GAP map00010,map01100,map01110,map01120,map01230,map04066,map05010 G Glyceraldehyde-3-phosphate dehydrogenase COG0057 Cluster_534677 V1281920 MALX map00010,map00500,map00520,map02060 G PTS System COG1263 Cluster_534678 V1281922 DLTA Q amino acid adenylation COG1020 Cluster_534679 V1281923 PURM map00230,map01100,map01110 F phosphoribosylaminoimidazole synthetase COG0150 Cluster_649247 V1281924 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_534680 V1281925 V Efflux ABC transporter, permease protein 0XPE8 Cluster_699449 V1281926 PANE map00770,map01100,map01110 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) COG1893 Cluster_534681 V1281927 NAPG map00910 C Quinol dehydrogenase periplasmic component COG1145 Cluster_563959 V1281930 YUGP S zinc metallopeptidase COG2738 Cluster_531917 V1281931 C radical SAM domain protein COG1032 Cluster_576690 V1281932 LEUC map00290,map00300,map00660,map01100,map01110,map01210,map01230 E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) COG0065 Cluster_531918 V1281934 APPA E Extracellular solute-binding protein, family 5 COG0747 Cluster_534682 V1281935 S conserved domain protein 0YAQR Cluster_534683 V1281936 M Cell wall binding repeat 2-containing protein COG2247 Cluster_531919 V1281937 S Family of unknown function (DUF490) 0XPFA Cluster_531921 V1281940 S RibD C-terminal domain 1177X Cluster_531922 V1281941 METTU_1963 L Transposase 0XRAH Cluster_534684 V1281943 V Abc transporter COG1132 Cluster_534685 V1281944 CZCA P heavy metal cation efflux protein CzcA COG3696 Cluster_607125 V1281946 S Abortive infection protein AbiGII 0XQHH Cluster_534686 V1281947 NHAC map00680 C Na H antiporter COG1757 Cluster_534687 V1281948 CAT map00281,map00620,map00626,map01110,map01120 C Transferase COG0427 Cluster_534688 V1281949 ACCA map00061,map00253,map00620,map00640,map00720,map01100,map01110,map01120 I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) COG0825 Cluster_534689 V1281950 S NA 11J4C Cluster_637274 V1281951 CWLV M n-acetylmuramoyl-l-alanine amidase COG0860 Cluster_534690 V1281952 V ABC transporter transmembrane region COG1132 Cluster_534691 V1281953 SP_1232 S Membrane COG4684 Cluster_534692 V1281954 RPLE map03010 J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COG0094 Cluster_731714 V1281956 SURE map00230,map00240,map00760,map01100,map01110 F Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity) COG0496 Cluster_832613 V1281957 VICX map03013 S domain protein COG1235 Cluster_599903 V1281958 YGFZ S Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) COG0354 Cluster_589532 V1281959 YJGI map00061,map00780,map01040,map01100 S Short-chain dehydrogenase reductase Sdr COG1028 Cluster_534695 V1281961 L DNA primase helicase 0ZVWQ Cluster_708659 V1281964 PM0594 S Protein of unknown function DUF262 COG1479 Cluster_670182 V1281968 INFC J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) COG0290 Cluster_534696 V1281969 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_534697 V1281972 map00400,map01100,map01110,map01230 E shikimate COG0703 Cluster_868173 V1281973 CBPA O DnaJ domain protein COG2214 Cluster_762569 V1281977 P (CBS) domain COG1253 Cluster_702482 V1281978 NHAR K transcriptional regulator, lysR family COG0583 Cluster_537554 V1281979 TGT J Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COG0343 Cluster_534698 V1281980 P Transporter COG0733 Cluster_537555 V1281982 S repeat protein 11IAG Cluster_731715 V1281984 TRML map04122 J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) COG0219 Cluster_801256 V1281985 S X-X-X-Leu-X-X-Gly heptad repeats COG1511 Cluster_534699 V1281986 BCOP_0524 L Transposase COG3464 Cluster_537557 V1281988 LLDD map00620,map01100 C Dehydrogenase COG1304 Cluster_670183 V1281989 YQGV S Domain of unknown function DUF77 COG0011 Cluster_534700 V1281990 SP_1331 K transcriptional regulator COG1737 Cluster_603513 V1281991 S DNA-binding protein COG3943 Cluster_537558 V1281993 DIVIB map04112 M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) COG1589 Cluster_534701 V1281995 PEPF E Oligoendopeptidase f COG1164 Cluster_755252 V1281997 DPNA L helicase COG4983 Cluster_621899 V1281998 ZNUA map02010 P periplasmic solute binding protein COG0803 Cluster_537560 V1281999 MODA map02010 P ABC transporter, periplasmic molybdate-binding protein COG0725 Cluster_534702 V1282000 T ATPase histidine kinase DNA gyrase B HSP90 domain protein 0XNMH Cluster_762570 V1282002 PURE map00230,map01100,map01110 F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) COG0041 Cluster_534703 V1282004 S NA 11MA7 Cluster_534704 V1282005 SUFC O feS assembly ATPase SufC COG0396 Cluster_534705 V1282006 S Outer membrane efflux protein 12145 Cluster_534706 V1282007 O -hydrogenase maturation factor COG0309 Cluster_725128 V1282010 S NA 11Y61 Cluster_805420 V1282012 YIDR S atp gtp-binding protein 16TET@proNOG Cluster_546207 V1282013 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 Cluster_537561 V1282014 P tonB-dependent Receptor COG4771 Cluster_534707 V1282019 CTPA M protease COG0793 Cluster_537563 V1282020 SLGD_00064 map02010 P ABC transporter COG1122 Cluster_637275 V1282022 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_758753 V1282023 YRBE Q ABC superfamily ATP binding cassette transporter permease protein COG0767 Cluster_610776 V1282025 PURM map00230,map01100,map01110 F phosphoribosylaminoimidazole synthetase COG0150 Cluster_637276 V1282026 V HNH endonuclease 0XW1B Cluster_534709 V1282029 RNHB map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0164 Cluster_534710 V1282030 YEII map00240 G kinase (PfkB family COG0524 Cluster_537564 V1282031 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_537566 V1282035 PYC map00020,map00620,map00720,map01100,map01120,map01230 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) COG1038 Cluster_852089 V1282036 G extracellular solute-binding protein family 1 0XQSR Cluster_540340 V1282038 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_702483 V1282039 GRDB S Selenoprotein B, glycine betaine sarcosine D-proline reductase family 0XPCF Cluster_925784 V1282040 S selenoprotein B, glycine betaine sarcosine D-proline reductase 123JW Cluster_848289 V1282041 T Response regulator of the LytR AlgR family COG3279 Cluster_537567 V1282042 LMRA V Abc transporter COG1132 Cluster_537568 V1282043 NAGD map00627,map01120 G had-superfamily hydrolase, subfamily iia COG0647 Cluster_537569 V1282044 SELB map00450,map00970 J Selenocysteine-specific translation elongation factor COG3276 Cluster_731716 V1282047 GCVPB map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG1003 Cluster_537570 V1282049 V abc transporter permease protein COG0577 Cluster_537571 V1282050 GCP O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG1214 Cluster_586252 V1282051 S c4-dicarboxylate anaerobic carrier COG1288 Cluster_534711 V1282052 EFPA G Efflux Protein 0ZJBD Cluster_781442 V1282053 CCPN K (CBS) domain COG0517 Cluster_744999 V1282055 map00230,map01100 F adenine phosphoribosyltransferase COG0503 Cluster_552125 V1282057 Y2191 K Antirepressor COG3617 Cluster_537572 V1282058 GRDB S Selenoprotein B, glycine betaine sarcosine D-proline reductase family 0XPCF Cluster_534712 V1282059 DNAE2 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase (By similarity) COG0587 Cluster_537573 V1282060 NHAC-1 map00680 C Na H antiporter COG1757 Cluster_537574 V1282061 TIG O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COG0544 Cluster_537575 V1282062 AGCS E amino acid carrier protein COG1115 Cluster_537576 V1282063 CYDD map02010 V ABC, transporter COG4988 Cluster_537577 V1282065 S Membrane COG3949 Cluster_766522 V1282066 K Transcriptional regulator, GntR family COG1725 Cluster_610777 V1282068 S DNA metabolism protein 11MJI Cluster_537579 V1282069 map02010,map02030 G Periplasmic binding protein LacI transcriptional regulator COG1879 Cluster_817168 V1282070 PTSA map00051,map01100,map02060 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) COG1925 Cluster_852090 V1282071 S Relaxase Mobilization nuclease domain protein 0XRAY Cluster_805422 V1282073 V ABC transporter COG1132 Cluster_805423 V1282074 V MatE COG0534 Cluster_540341 V1282075 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_537580 V1282076 P tonB-dependent receptor plug 0XSMW Cluster_670184 V1282080 RRMJ J Hemolysin A COG1189 Cluster_900946 V1282082 S NA 11FGF Cluster_880328 V1282083 S NA 11RWW Cluster_715212 V1282084 YCEG F aminodeoxychorismate lyase COG1559 Cluster_537582 V1282086 IGA O Immunoglobulin A1 protease 1214T Cluster_793317 V1282088 EF0617 S Membrane 0YGUE Cluster_670185 V1282090 VIRE L Virulence-associated protein e COG5545 Cluster_537583 V1282091 HYDE map00780,map01100 H radical SAM domain protein COG0502 Cluster_563960 V1282093 S phage portal protein, SPP1 0ZZDC Cluster_537585 V1282096 S NA 123IR Cluster_625688 V1282098 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_537586 V1282099 K, T Pfam:Hist_Kin_Sens COG4936 Cluster_537587 V1282100 SERP0565 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_603516 V1282101 GLPG S Rhomboid family COG0705 Cluster_762571 V1282103 CCMC O cytochrome C COG0755 Cluster_540342 V1282104 CCA map03013,map03018 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate COG0617 Cluster_855870 V1282107 S NA 0YVM8 Cluster_570251 V1282108 S NA 0YCKF Cluster_725129 V1282109 F Hydroxymethylpyrimidine transporter CytX COG1457 Cluster_657454 V1282110 K Transcriptional regulator, luxr family COG2197 Cluster_679008 V1282111 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_670186 V1282113 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_560982 V1282114 S NA 0Z8PS Cluster_715213 V1282115 QSEC map02020 T Histidine kinase 174CG@proNOG Cluster_570252 V1282116 T FHA domain protein 11FQP Cluster_537589 V1282117 HCP C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) COG1151 Cluster_537590 V1282118 P TonB dependent receptor 0XNNV Cluster_781443 V1282119 L DNA alkylation repair enzyme COG4912 Cluster_540344 V1282121 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_825032 V1282122 ENC_23920 S Phospholipid glycerol acyltransferase COG3176 Cluster_785523 V1282123 PHYA S Phospholipid glycerol acyltransferase COG3176 Cluster_614496 V1282124 FABZ map00061,map00780,map01100 I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) COG0764 Cluster_537591 V1282125 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_540345 V1282126 FPRA C domain protein COG0426 Cluster_552126 V1282127 map00680,map01120 S esterase COG0627 Cluster_537592 V1282128 CAPA M Capsule synthesis protein COG2843 Cluster_537593 V1282132 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_537594 V1282134 GLXK map00260,map00561,map00630,map01100,map01110 G Glycerate kinase COG1929 Cluster_540347 V1282136 O C-terminal, D2-small domain, of ClpB protein COG0542 Cluster_715214 V1282137 CAT1 map00281,map00620,map00626,map01110,map01120 C Transferase COG0427 Cluster_832615 V1282138 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_696172 V1282141 DPPD map02010 E, P (ABC) transporter COG0444 Cluster_537595 V1282142 map00300,map00550,map01100 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) COG0770 Cluster_540348 V1282143 AROD map00400,map01100,map01110,map01230 E Type I DHQase COG0710 Cluster_552127 V1282144 P TonB-dependent Receptor Plug 11DY5 Cluster_537596 V1282146 S RelA SpoT domain protein 0XPFE Cluster_537597 V1282147 MTGA map00550 M Monofunctional biosynthetic peptidoglycan transglycosylase COG0744 Cluster_540349 V1282148 GLGD map00500,map00520,map01100,map01110 M glucose-1-phosphate adenylyltransferase, glgd subunit COG0448 Cluster_537598 V1282150 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_537599 V1282151 SCPA S Segregation and condensation protein COG1354 Cluster_540351 V1282152 TAGO M Glycosyl transferase, family 4 COG0472 Cluster_537600 V1282153 MALA S maltodextrose utilization protein MalA COG5521 Cluster_540352 V1282155 GLK map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G Glucokinase COG1940 Cluster_540353 V1282156 S Sss sodium solute transporter superfamily COG4146 Cluster_555014 V1282157 S HTH_XRE 0ZZ7A Cluster_537601 V1282158 KUP P Transport of potassium into the cell (By similarity) COG3158 Cluster_540354 V1282159 LACZ map00052,map00511,map00600,map01100 G beta galactosidase small chain COG3250 Cluster_848290 V1282161 AGAV map00052,map02060 G PTS System COG3444 Cluster_537602 V1282162 O AhpC Tsa family 0YT1V Cluster_540355 V1282163 SP_0742 S degv family COG1307 Cluster_537603 V1282164 M Inherit from NOG: domain protein 0XQTW Cluster_864226 V1282166 TRPP S tryptophan transport protein 11UPK Cluster_540356 V1282167 NHAA map00680 P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) COG3004 Cluster_540357 V1282168 RFAG map00051 M glycosyltransferase group 2 family protein COG0463 Cluster_840371 V1282171 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_781444 V1282172 PHES map00970 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 Cluster_665869 V1282173 HISA map00340,map01100,map01110,map01230 E Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase COG0106 Cluster_721776 V1282174 KDGK map00030,map00040,map01100,map01120 G pfkb domain protein COG0524 Cluster_540358 V1282175 S NA 0ZTYV Cluster_537604 V1282176 S domain protein 12C1H Cluster_702484 V1282177 S NA 1260K Cluster_540359 V1282179 TAUA map02010 P ABC transporter substrate-binding protein COG0715 Cluster_540360 V1282180 YDJG S Zinc finger domain 0XNNM Cluster_583058 V1282181 HYDE map00780,map01100 H radical SAM domain protein COG0502 Cluster_679009 V1282184 YAAQ S protein from nitrogen regulatory protein P-II COG3870 Cluster_537605 V1282186 S NA 11Q55 Cluster_546208 V1282189 ARTM2 E amino acid AbC transporter COG0765 Cluster_540362 V1282190 YUGP S zinc metallopeptidase COG2738 Cluster_540363 V1282191 DTD J Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) COG1490 Cluster_540364 V1282192 G Aamy COG0366 Cluster_540365 V1282193 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_540366 V1282194 RNR map03018 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 Cluster_540367 V1282195 S oxidoreductase COG0673 Cluster_540368 V1282196 map00190,map00910,map01100 C NADH dehydrogenase subunit g (EC 1.6.5.3) COG1034 Cluster_540369 V1282197 map00040,map00500,map01100 S NA 11GMI Cluster_805424 V1282199 THIS map04122 H thiamine biosynthesis protein ThiS COG2104 Cluster_657457 V1282201 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_560983 V1282202 S Membrane COG0628 Cluster_540371 V1282203 ADDA L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation COG1074 Cluster_573481 V1282205 MUTS2 map03430 L muts2 protein COG1193 Cluster_540372 V1282206 GLGX map00500,map01100,map01110 G glycogen debranching enzyme glgx COG1523 Cluster_540373 V1282207 V ABC transporter, ATP-binding permease protein COG1132 Cluster_543271 V1282209 NAGE map00010,map00500,map00520,map02060 G PTS System COG1263 Cluster_540375 V1282213 NANA map00300,map00520,map01100,map01110,map01120,map01230 E dihydrodipicolinate COG0329 Cluster_679010 V1282214 S Phage terminase small subunit 11F23 Cluster_592936 V1282215 M Glycosyl transferase family 2 COG0463 Cluster_540376 V1282216 PURR12 K Transcriptional regulator COG1609 Cluster_540377 V1282217 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_696173 V1282218 map00270,map00450,map00670,map01100,map01110,map01230 S vitamin B12 dependent methionine synthase activation 11H9C Cluster_909312 V1282219 map00860,map01100,map01110 H Uroporphyrinogen decarboxylase (URO-D) COG0407 Cluster_645147 V1282220 QUEG C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) COG1600 Cluster_540378 V1282221 S S-layer homology domain 0ZUGE Cluster_688010 V1282222 S NA 0XT0J Cluster_900947 V1282223 BCRA map02010 V ABC transporter COG1131 Cluster_543272 V1282224 YLME F alanine racemase domain protein COG0325 Cluster_725131 V1282225 EFP J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) COG0231 Cluster_540379 V1282226 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_793318 V1282227 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_637277 V1282228 PURF map00230,map00250,map01100,map01110 F amidophosphoribosyltransferase (EC 2.4.2.14) COG0034 Cluster_793319 V1282229 S NA 186YF@proNOG Cluster_543273 V1282230 KDGT P The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) 0XNUJ Cluster_848291 V1282231 DCUD C C4-dicarboxylate transporter COG3069 Cluster_540380 V1282235 LACR2 K transcriptional regulator DeoR family COG1349 Cluster_683581 V1282236 PRDD map00330 S D-proline reductase 0ZP81 Cluster_540381 V1282237 map00860,map01100 H Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) COG2038 Cluster_540382 V1282238 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_543274 V1282239 YLOV S dak2 domain fusion protein ylov COG1461 Cluster_540383 V1282240 DUSB J Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_557938 V1282241 S domain protein COG1418 Cluster_540384 V1282243 S NA 0YDU4 Cluster_540385 V1282244 YNBB map00260,map00270,map00450,map01100,map01230 P aluminum resistance protein COG4100 Cluster_563961 V1282245 SUFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_679011 V1282248 LIVH map02010 E Branched-chain amino acid transport system permease COG0559 Cluster_614497 V1282249 S Oxidoreductase short chain dehydrogenase reductase family COG0300 Cluster_543275 V1282252 map03440 K Inherit from firmNOG: Transcriptional regulator COG2865 Cluster_905241 V1282257 S Lipoprotein LpqB, GerMN domain protein 11K5J Cluster_884456 V1282258 SMPB O Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) COG0691 Cluster_543277 V1282259 PEPF map04614,map05143 E Oligoendopeptidase f COG1164 Cluster_540388 V1282260 S ErfK YbiS YcfS YnhG COG1376 Cluster_540390 V1282264 S amidoligase enzyme 0XSK4 Cluster_540391 V1282266 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_543278 V1282267 K ParB-like COG1475 Cluster_836432 V1282268 S NA 0YBND Cluster_805425 V1282269 TRAJ S conjugative transposon 0XP5P Cluster_543279 V1282272 DNAJ O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 Cluster_832617 V1282273 YTJA S UPF0391 membrane protein YtjA 185Y6@proNOG Cluster_543280 V1282275 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_573482 V1282276 YHFE E m42 family COG1363 Cluster_741689 V1282281 ERA M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 Cluster_540392 V1282282 YUGP S zinc metallopeptidase COG2738 Cluster_543282 V1282283 S DNA-binding protein hu 11T81 Cluster_543284 V1282285 LGT M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 Cluster_670187 V1282287 PEPP E peptidase, M24 COG0006 Cluster_762573 V1282288 YLQC S UPF0109 protein COG1837 Cluster_589534 V1282289 map02010 P Cobalt transport protein COG0619 Cluster_738293 V1282290 ISPH map00900,map01100,map01110,map03010 I Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) COG0761 Cluster_614498 V1282291 map00040,map01100 G dehydratase COG2721 Cluster_543285 V1282292 SURB S G5 domain protein 0ZVV3 Cluster_543286 V1282293 MDLB map02010 V ABC transporter COG1132 Cluster_674570 V1282299 YJEE S protein family UPF0079, ATPase COG0802 Cluster_543288 V1282304 LACZ map00052,map00511,map00600,map01100 G beta-galactosidase COG3250 Cluster_852092 V1282305 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_540394 V1282307 ZNUA map02010 P periplasmic solute binding protein COG0803 Cluster_766525 V1282308 CYST P binding-protein-dependent transport systems inner membrane Component COG4132 Cluster_817169 V1282309 MALF E Binding-protein-dependent transport systems, inner membrane component COG1177 Cluster_543289 V1282310 CRR map00010,map00500,map00520,map02060 G Pts system COG2190 Cluster_560984 V1282314 YBBK J Purine nucleoside phosphorylase COG1683 Cluster_625689 V1282315 S ABC transporter solute-binding protein COG4134 Cluster_543291 V1282318 MALZ map00052,map00500,map01100,map04973 G alpha amylase, catalytic region COG0366 Cluster_665870 V1282320 RARA L recombination factor protein RarA COG2256 Cluster_543293 V1282321 G Major Facilitator 11MCP Cluster_543294 V1282322 BGLB map00010 G 6-phospho-beta-glucosidase (EC 3.2.1.86) COG2723 Cluster_751779 V1282324 GLDA map00561,map01100 C glycerol dehydrogenase COG0371 Cluster_543295 V1282325 ARDC L antirestriction protein COG4227 Cluster_543296 V1282326 GUAA map00230,map00983,map01100 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 Cluster_543297 V1282327 CADA P cadmium-exporting ATPase COG2217 Cluster_543298 V1282328 GRAR T response regulator COG0745 Cluster_543299 V1282329 IROC map02010 V abc transporter COG1132 Cluster_674571 V1282331 S domain protein COG5012 Cluster_543300 V1282336 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_563962 V1282337 ATPB map00190,map00195,map01100 C it plays a direct role in the translocation of protons across the membrane (By similarity) COG0356 Cluster_543301 V1282338 G Major Facilitator COG0477 Cluster_543302 V1282339 GLNN map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG3968 Cluster_543303 V1282340 SSCG_06117 S degv family COG1307 Cluster_543304 V1282341 UVRC map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 Cluster_543305 V1282342 TREC map00052,map00500,map01100 G Aamy COG0366 Cluster_543306 V1282343 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate (By similarity) COG0167 Cluster_653339 V1282345 S Relaxase Mobilization nuclease domain protein 0XRAY Cluster_543307 V1282346 L type iii restriction protein res subunit COG1061 Cluster_543308 V1282347 L helicase domain protein COG0553 Cluster_543309 V1282349 S domain protein 12C1H Cluster_543310 V1282351 S plasmid recombination enzyme 1004W Cluster_543311 V1282352 T Anti-feci sigma factor, fecr COG3712 Cluster_543312 V1282353 V ABC transporter, ATP-binding permease protein COG1132 Cluster_618255 V1282354 GLTS E Sodium Glutamate Symporter COG0786 Cluster_543313 V1282355 YJGR S ATP-binding protein COG0433 Cluster_543314 V1282357 S radical SAM domain protein COG4277 Cluster_543315 V1282359 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_649248 V1282360 K ParB-like COG1475 Cluster_618256 V1282361 P receptor COG1629 Cluster_546210 V1282362 CDR P pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_543316 V1282367 S NA 0Y1Y4 Cluster_543317 V1282368 S NA 1015R Cluster_748347 V1282369 OGT L Methyltransferase COG0350 Cluster_696174 V1282371 S nucleoside recognition domain protein COG3314 Cluster_546211 V1282372 MDLA V ABC transporter, ATP-binding protein COG1132 Cluster_543318 V1282373 DNAG map03030 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 Cluster_653340 V1282374 LPXD map00540,map01100 M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) COG1044 Cluster_543319 V1282375 S NA 0YCB1 Cluster_741690 V1282376 AGAC map00052,map02060 G PTS System COG3715 Cluster_543320 V1282377 L Dna topoisomerase COG0550 Cluster_674572 V1282378 S Putative amidoligase enzyme 0ZZMV Cluster_543322 V1282380 CMP M Major outer membrane protein 17MV0@proNOG Cluster_785524 V1282381 YAAT S psp1 domain protein COG1774 Cluster_543323 V1282382 FPRA C domain protein COG0426 Cluster_543324 V1282383 G transporter 0XNQK Cluster_797281 V1282385 TRMFO J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) COG1206 Cluster_661662 V1282386 S Flavodoxin-like fold COG0655 Cluster_567160 V1282387 LACI K transcriptional regulator lacI family COG1609 Cluster_653341 V1282389 TRUB J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 Cluster_629391 V1282391 map00051,map00520,map01100,map02060 G PTS System COG3715 Cluster_543325 V1282392 S NA 0YK82 Cluster_614499 V1282395 S Protein of unknown function (DUF2634) 11VAZ Cluster_728451 V1282396 PPNK map00760,map01100 G Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) COG0061 Cluster_868174 V1282397 RRMJ J Hemolysin A COG1189 Cluster_573483 V1282399 GMK map00230,map01100 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG0194 Cluster_543327 V1282400 P receptor COG1629 Cluster_657458 V1282401 S Inherit from COG: virion core protein (Lumpy skin disease COG4260 Cluster_618257 V1282402 S Inherit from NOG: S-layer protein 0ZUVU Cluster_793321 V1282404 map00330,map01110,map01230 E Ornithine Cyclodeaminase COG2423 Cluster_880330 V1282405 T UspA domain-containing protein COG0589 Cluster_546212 V1282406 CITM C Citrate transporter COG2851 Cluster_546213 V1282407 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_731721 V1282408 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_864227 V1282409 TRMD map00900,map01100,map01110 J Specifically methylates guanosine-37 in various tRNAs (By similarity) COG0336 Cluster_770229 V1282410 RPLS map03010 J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) COG0335 Cluster_543328 V1282412 CPN_0542 map02010 P ABC transporter COG1121 Cluster_813441 V1282414 THIC map00730,map01100 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) COG0422 Cluster_546214 V1282415 P Chloride channel COG0038 Cluster_596407 V1282417 S NA 0Z6SF Cluster_751780 V1282420 S integral membrane protein 11P1U Cluster_543329 V1282421 S filamentation induced by cAMP protein Fic COG3177 Cluster_688011 V1282423 map00564,map01100 I Phospholipase D Transphosphatidylase COG1502 Cluster_649249 V1282424 PNTB map00760,map01100 C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) COG1282 Cluster_665871 V1282425 PEPA map00480,map01100 E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) COG0260 Cluster_789524 V1282426 RSFS S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) COG0799 Cluster_797282 V1282427 YQEK map00760,map01100 H Metal Dependent Phosphohydrolase COG1713 Cluster_825033 V1282428 YJAG S Conserved Protein COG3068 Cluster_546215 V1282430 VIOA map00362,map00363,map00626,map00650,map00903,map01100,map01110,map01120 E DegT DnrJ EryC1 StrS COG0399 Cluster_570253 V1282432 PROA map00330,map01100,map01230 E Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) COG0014 Cluster_688012 V1282434 S domain M protein repeat protein 0XPG7 Cluster_817170 V1282435 SFSA L Sugar fermentation stimulation protein homolog COG1489 Cluster_546217 V1282437 DXR map00900,map01100,map01110 I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) COG0743 Cluster_755254 V1282438 map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG2812 Cluster_573484 V1282440 POTD map02010 E ABC transporter COG0687 Cluster_859926 V1282441 GLNQ map02010 E ABC transporter, ATP-binding protein COG1126 Cluster_576691 V1282445 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG0469 Cluster_586254 V1282448 ANSA map00250,map00460,map00910,map01100,map01110 E L-asparaginase COG0252 Cluster_546219 V1282449 S Plasmid recombination enzyme 0XTDI Cluster_546220 V1282452 CPDB map00230,map00240,map00760,map01100,map01110 F 5-nucleotidase COG0737 Cluster_844411 V1282454 GLSA map00250,map00330,map00471,map00910,map01100,map01120,map04724,map04727,map04964 E Glutaminase COG2066 Cluster_589535 V1282455 FECD map02010 P Permease protein COG0609 Cluster_725132 V1282457 SPOU2 map00340,map00350,map00624,map01120 J tRNA rRNA methyltransferase COG0566 Cluster_546221 V1282458 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_546222 V1282459 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_546223 V1282460 RC1_2786 L transposase COG5433 Cluster_758757 V1282461 LDH map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120 C L-lactate dehydrogenase COG0039 Cluster_674573 V1282462 YCIO J sua5 ycio yrdc ywlc family protein COG0009 Cluster_570254 V1282463 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_546224 V1282465 P tonB-dependent Receptor 0XP2F Cluster_546225 V1282466 DCTM G C4-dicarboxylate transport system (Permease large COG1593 Cluster_546226 V1282467 ATPB map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) COG1156 Cluster_546227 V1282468 S NA 11P6W Cluster_546229 V1282471 HILA K Invasion protein COG3710 Cluster_762576 V1282472 CTPC map00190 P heavy metal translocating P-type ATPase COG2217 Cluster_546230 V1282474 PITRM1 O peptidase COG1026 Cluster_546231 V1282475 FECE map02010 P abc transporter atp-binding protein COG4604 Cluster_637279 V1282476 CTPF P ATPase, P-type (transporting), HAD superfamily, subfamily IC COG0474 Cluster_546233 V1282480 YCHF J gtp-binding protein COG0012 Cluster_734967 V1282481 YRZL S UPF0297 protein COG4472 Cluster_546234 V1282482 HSDS V type I restriction modification DNA specificity domain COG0732 Cluster_813442 V1282483 TTDB map00020,map00630,map00720,map01100,map01110,map01120 C fumarate COG1838 Cluster_549235 V1282487 SUFB O FeS assembly protein SUFB COG0719 Cluster_546237 V1282488 YBIU S Protein of unknown function (DUF1479) 16SAU@proNOG Cluster_589536 V1282489 E Peptidase m29 aminopeptidase ii COG2309 Cluster_828817 V1282491 K Transcriptional regulator, TetR family 10SSW Cluster_549236 V1282493 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_546240 V1282495 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_546241 V1282500 P TonB-dependent receptor Plug 0XNPQ Cluster_579817 V1282502 S Membrane 0XQTX Cluster_563963 V1282503 S S-layer homology domain 11R9R Cluster_546242 V1282504 S NA 0YIHX Cluster_546243 V1282507 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_546244 V1282508 L D12 class N6 adenine-specific DNA methyltransferase 110K5 Cluster_734968 V1282509 S S-layer domain protein 12C8X Cluster_546245 V1282510 S Inherit from COG: ATPase (AAA COG1373 Cluster_546246 V1282511 ALGI M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_546247 V1282512 P Natural resistance-associated macrophage protein COG1914 Cluster_549238 V1282513 BL03948 S nucleoside recognition domain protein COG3314 Cluster_546249 V1282515 S Family of unknown function (DUF490) 0ZVTR Cluster_645149 V1282516 PFLA O Pyruvate formate-lyase COG1180 Cluster_576692 V1282517 FDXA C Ferredoxin COG1146 Cluster_555016 V1282518 RPSA map00900,map01100,map01110,map03010 J Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) COG0761 Cluster_848292 V1282519 TUSE map04122 P Part of a sulfur-relay system (By similarity) COG2920 Cluster_741692 V1282520 ACYP map00620,map00627,map01120 C K01512 acylphosphatase EC 3.6.1.7 COG1254 Cluster_549239 V1282521 S prophage protein 0ZR61 Cluster_549240 V1282522 S Uncharacterised Sugar-binding Domain 0YG17 Cluster_546250 V1282523 M Cell wall binding repeat 2-containing protein COG2247 Cluster_549241 V1282524 GSIB map02010 E Extracellular solute-binding protein, family 5 COG0747 Cluster_546251 V1282525 PURA map00230,map00250,map01100 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis COG0104 Cluster_549242 V1282526 METY map00270,map00450,map00920,map01100,map01110,map01230 E O-acetylhomoserine COG2873 Cluster_579818 V1282527 S copper amine 121X1 Cluster_546252 V1282528 ESTS S sialic acid-specific 9-O-acetylesterase 0XQ2Q Cluster_715215 V1282529 S NA 16RWI@proNOG Cluster_546253 V1282530 V Type I restriction enzyme R protein N terminus (HSDR_N) COG0610 Cluster_629392 V1282531 O peptidylprolyl cis-trans isomerase COG0760 Cluster_549243 V1282532 LACZ map00052,map00511,map00600,map01100 G Glycoside hydrolase family 2 TIM barrel COG3250 Cluster_546254 V1282533 map00730,map01100 H IA, variant 3 COG0637 Cluster_549244 V1282535 DPNA L helicase COG4646 Cluster_546255 V1282536 map00550 M Peptidase S13, D-Ala-D-Ala carboxypeptidase C COG2027 Cluster_762577 V1282537 S YitT family COG1284 Cluster_821065 V1282539 S NA 0XUY7 Cluster_549245 V1282540 HEMZ map00860,map01100,map01110 H coproporphyrinogen III oxidase COG0635 Cluster_549246 V1282541 LYTR2 K TRANSCRIPTIONal COG1316 Cluster_549247 V1282542 SCRA map00500,map02060 G PTS system COG2190 Cluster_549248 V1282543 P TonB-dependent Receptor Plug 0XNNV Cluster_549249 V1282544 O Zn-dependent protease COG5504 Cluster_751781 V1282545 DNAC L DNA replication protein COG1484 Cluster_670189 V1282546 PPK map00190,map03018 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) COG0855 Cluster_797283 V1282548 PORG map00020,map00720,map01100,map01120 C oxidoreductase COG1014 Cluster_549251 V1282550 K Transcriptional regulator, MarR family 0YH1E Cluster_549252 V1282551 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_614500 V1282552 UPPP map00550 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) COG1968 Cluster_549253 V1282555 map02020 K Transcriptional regulator, ARAC family COG4753 Cluster_549254 V1282557 M Membrane 0XT9Z Cluster_549255 V1282558 map02010 V ABC transporter COG1132 Cluster_549257 V1282563 V Mate efflux family protein COG0534 Cluster_718480 V1282564 RECJ map03410,map03430,map03440 L Single-stranded-DNA-specific exonuclease (RecJ) COG4199 Cluster_549258 V1282565 CLOCL_3187 S NA 10NSM Cluster_555017 V1282566 S Inherit from COG: Alpha beta hydrolase COG0596 Cluster_549259 V1282567 TATD L Hydrolase, tatD family COG0084 Cluster_549260 V1282568 MUTS2 map03430 L muts2 protein COG1193 Cluster_599905 V1282569 P hemerythrin hhe cation binding domain protein COG2461 Cluster_599906 V1282570 I esterase COG0657 Cluster_549261 V1282571 V ABC transporter COG1131 Cluster_549262 V1282575 M NlpC/P60 family COG0791 Cluster_745002 V1282576 S NA 0YJQ6 Cluster_579820 V1282577 ATPB map00190,map00195,map01100 C it plays a direct role in the translocation of protons across the membrane (By similarity) COG0356 Cluster_618258 V1282578 AHPF O Alkyl hydroperoxide reductase COG3634 Cluster_770231 V1282579 map02010 P Abc transporter, ATP-binding protein COG1122 Cluster_549263 V1282581 FOPA M ompA family 10ZT3 Cluster_567161 V1282583 DCP E oligopeptidase A COG0339 Cluster_721778 V1282584 K Transcriptional Regulator AraC Family 0ZYR5 Cluster_825034 V1282585 RBBA V ABC transporter COG1131 Cluster_773924 V1282586 YECF S cytoplasmic protein 17K3H@proNOG Cluster_557941 V1282587 DPPB P ABC transporter (Permease COG0601 Cluster_552128 V1282588 P Arylsulfatase COG3119 Cluster_563964 V1282589 S tonB-dependent Receptor 0XNVP Cluster_552129 V1282590 S gp37gp68 family COG4422 Cluster_552130 V1282591 S NA 0YD1F Cluster_549264 V1282593 THIM map00730,map01100 H 4-methyl-5-beta-hydroxyethylthiazole kinase COG2145 Cluster_705587 V1282594 S Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) 0XTXX Cluster_555018 V1282595 S NA 11NM2 Cluster_549265 V1282597 VIRE L Virulence-associated protein e COG5545 Cluster_573485 V1282598 LACC map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G tagatose-6-phosphate kinase COG1105 Cluster_552131 V1282599 S Endonuclease Exonuclease phosphatase 0ZJ9Y Cluster_679012 V1282600 map00190,map00680,map01100 C V-type sodium ATP synthase, subunit G 0XZCI Cluster_549266 V1282602 AGCS E amino acid carrier protein COG1115 Cluster_549267 V1282603 P TonB dependent receptor 0XNNV Cluster_552132 V1282604 S NA 0Y843 Cluster_552133 V1282605 ETFA map00910 C Electron transfer flavoprotein COG2025 Cluster_549269 V1282609 FOLE map00790,map01100 H GTP cyclohydrolase i COG0302 Cluster_692435 V1282611 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_629393 V1282612 CRCB D Protein CrcB homolog COG0239 Cluster_549271 V1282613 FMT map00670,map00970 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 Cluster_589537 V1282615 S anti-restriction protein ArdA 0ZSUS Cluster_552135 V1282618 S domain protein 12BYK Cluster_552136 V1282620 T Histidine kinase 0XNMH Cluster_618259 V1282621 LACA map00350,map00362,map00627,map00642,map00903,map01120 S Galactoside O-acetyltransferase COG0110 Cluster_705588 V1282622 FRLB G catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine COG2222 Cluster_592937 V1282623 V abc transporter permease protein 0XQE2 Cluster_583059 V1282626 S NA 0YY9N Cluster_573486 V1282627 PUTP E Sodium proline symporter COG0591 Cluster_552137 V1282628 PURL F phosphoribosylformylglycinamidine synthase COG0047 Cluster_633219 V1282629 PROA map00330,map01100,map01230 E Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) COG0014 Cluster_552138 V1282630 THRC map00260,map00750,map01100,map01120,map01230 E Threonine synthase COG0498 Cluster_549273 V1282632 SURB S G5 domain protein 0ZVV3 Cluster_552139 V1282633 BL01171 P hemerythrin hhe cation binding domain protein COG2461 Cluster_552140 V1282634 S Exporters of the RND superfamily COG1033 Cluster_552141 V1282635 PTSP map00051,map01100,map02060 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) COG1080 Cluster_552142 V1282636 S NA 11FTC Cluster_549274 V1282637 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_552143 V1282638 S PAP2 superfamily domain protein 11HHM Cluster_599907 V1282640 S NA 0YDXY Cluster_549275 V1282642 OPUCB map02010 E ABC transporter COG1174 Cluster_552144 V1282643 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_625690 V1282644 SPEA map00330,map01100 E Catalyzes the biosynthesis of agmatine from arginine (By similarity) COG1166 Cluster_552145 V1282645 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_589538 V1282646 S Protein of unknown function DUF262 0ZMV0 Cluster_552146 V1282647 map02020 T regulatoR COG2197 Cluster_552147 V1282648 S Caspase domain 0ZIUZ Cluster_552148 V1282649 METK S methionine adenosyltransferase 0YTXD Cluster_552149 V1282652 PHEB map00400,map01100,map01110,map01230 E Chorismate mutase COG2876 Cluster_583060 V1282653 L DNA helicase COG1112 Cluster_731722 V1282655 UDP map00240,map00983,map01100 F Uridine phosphorylase COG2820 Cluster_731723 V1282657 QUEA J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) COG0809 Cluster_864232 V1282658 TGT J Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) COG0343 Cluster_618260 V1282659 O Pyruvate formate-lyase COG1180 Cluster_599908 V1282660 S Glucan-binding protein C 1001J Cluster_859928 V1282662 BL02049 S methyltransferase 11GJV Cluster_657460 V1282666 S NA 0ZEDM Cluster_552150 V1282667 map00270,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01230 E Aminotransferase class i COG1448 Cluster_549276 V1282668 GLK map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G Glucokinase COG1940 Cluster_549277 V1282669 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_629394 V1282670 L Inherit from COG: transposase COG3666 Cluster_721780 V1282671 P binding-protein-dependent transport systems inner membrane Component 11QVI Cluster_552151 V1282672 S NA 0YZ82 Cluster_552152 V1282673 V abc transporter permease protein 0ZW5X Cluster_797284 V1282675 LCTP C L-lactate COG1620 Cluster_552153 V1282678 SERC map00260,map00680,map00750,map01100,map01120,map01230 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) COG1932 Cluster_621900 V1282679 K transcriptional regulator 175I5@proNOG Cluster_552154 V1282680 COMEC S ComEC Rec2-like protein COG0658 Cluster_563965 V1282681 S copper amine 121X1 Cluster_552156 V1282684 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_552157 V1282685 ASPC map00250,map00290,map01100,map01110,map01210,map01230 E Aminotransferase COG0436 Cluster_738294 V1282686 S Auxin Efflux Carrier COG0679 Cluster_828819 V1282689 S NA 0YQ6S Cluster_552160 V1282691 PHBA map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map02020 I acetyl-CoA COG0183 Cluster_552161 V1282692 POLA_2 L DNA polymerase 0XRUF Cluster_596410 V1282693 S Domain of unknown function (DUF1788) 11KAX Cluster_552162 V1282694 V T5orf172 0XQ8K Cluster_618261 V1282699 map00051,map00520,map01100 M RmlD substrate binding domain COG1089 Cluster_552166 V1282700 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_552167 V1282701 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_715218 V1282702 MUTT L hydrolase COG0494 Cluster_552168 V1282703 YMDB S appr-1-p processing domain protein COG2110 Cluster_552169 V1282704 V NA 0Y1U9 Cluster_557942 V1282705 O Peptidase, M16 COG0612 Cluster_715219 V1282706 S NA 11P3U Cluster_621901 V1282708 S TraX protein 11N9P Cluster_586256 V1282711 CTPC map00190 P heavy metal translocating P-type ATPase COG2217 Cluster_555019 V1282712 S Organic solvent tolerance protein 0XQ3B Cluster_603518 V1282713 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_552171 V1282714 V acriflavin resistance protein COG0841 Cluster_552172 V1282716 I Diacylglycerol kinase catalytic domain COG1597 Cluster_552173 V1282717 HRPA L ATP-dependent helicase COG1643 Cluster_734969 V1282719 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L dna polymerase iii COG0847 Cluster_932418 V1282720 S Beta-lactamase domain protein COG1237 Cluster_607128 V1282721 OCAR_7578 map00051,map00053,map00520,map01100,map01120,map02060 G pts system COG2893 Cluster_770232 V1282722 RFBA map00521,map00523,map01100,map01110 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) COG1209 Cluster_552174 V1282727 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_579821 V1282729 S NA 0Z62C Cluster_801257 V1282733 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_592938 V1282734 CYDC map02010 V Abc transporter COG1132 Cluster_679013 V1282735 S integral membrane protein 11TVJ Cluster_813443 V1282736 S NA 0ZHU9 Cluster_555020 V1282737 SULP P sulfate transporter COG0659 Cluster_653342 V1282739 G hydrolase family 18 COG3858 Cluster_758758 V1282740 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_661663 V1282741 PBPA map00550 M penicillin-binding protein COG0768 Cluster_828820 V1282744 S NA 11WI9 Cluster_552176 V1282745 CSHA map03018 L DEAD DEAH box helicase COG0513 Cluster_683582 V1282747 EXUT map02020 G Major facilitator superfamily MFS_1 16R9H@proNOG Cluster_836435 V1282748 DGT map00230 F deoxyguanosinetriphosphate triphosphohydrolase-like protein COG0232 Cluster_925789 V1282749 DNAG map03030 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 Cluster_614501 V1282750 REPW S Plasmid Encoded RepA Protein 16TFD@proNOG Cluster_555021 V1282751 S domain protein COG1917 Cluster_552177 V1282753 S Membrane 0ZI5H Cluster_552178 V1282755 CVAB map02010,map04626 V Colicin V processing peptidase COG2274 Cluster_552179 V1282756 RBSR K Transcriptional regulator COG1609 Cluster_828821 V1282757 RIBH map00740,map01100 H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) COG0054 Cluster_817172 V1282759 NORV map05132 C domain protein COG0426 Cluster_586257 V1282760 VICK T Histidine kinase 0XQQ4 Cluster_555022 V1282763 NFED O nodulation efficiency protein D COG1030 Cluster_555023 V1282766 ATPA map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_555024 V1282767 V Eco57I restriction endonuclease COG0827 Cluster_688014 V1282768 FHUF P ferric iron reductase COG4114 Cluster_692436 V1282771 MANY map00051,map00520,map01100,map02060 G PTS System COG3715 Cluster_552182 V1282772 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_817173 V1282774 S Toxin-antitoxin system, toxin component, RelE family 123KX Cluster_868177 V1282775 S NA 0YJQ6 Cluster_560985 V1282777 ISDF map02010 P Permease protein COG0609 Cluster_633220 V1282778 K ParB-like COG1475 Cluster_552183 V1282780 SOV S Gliding motility-related protein 0XPT8 Cluster_555025 V1282781 S ABC transporter, ATPase COG3044 Cluster_567162 V1282782 map03420,map03430 L helicase COG0210 Cluster_552184 V1282783 S Acetyltransferase GNAT Family 124QK Cluster_555026 V1282785 MUTF map02010 V ABC transporter, ATP-binding protein COG1131 Cluster_721781 V1282790 SP_1668 S TIGR02206 family 11T9J Cluster_555027 V1282791 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_555028 V1282795 NHAP P Potassium proton antiporter COG3263 Cluster_552186 V1282796 S relaxase mobilization nuclease domain protein 0XNXG Cluster_555029 V1282798 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_555031 V1282804 GLGB map00500,map01100,map01110 G 1,4-alpha-glucan branching enzyme COG0296 Cluster_805431 V1282805 S phospholipase 11NUJ Cluster_555032 V1282806 FPRA C domain protein COG0426 Cluster_555033 V1282807 FUCP G glucose galactose transporter COG0738 Cluster_555034 V1282808 map00550,map02010 P ABC transporter 11QT0 Cluster_555035 V1282809 PFLA O Pyruvate formate-lyase COG1180 Cluster_711856 V1282812 T protein tyrosine serine phosphatase COG2365 Cluster_555037 V1282813 YAAO map00310,map00330,map00960,map01100,map01110 E decarboxylase COG1982 Cluster_555038 V1282814 MIAB J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) COG0621 Cluster_777621 V1282815 S NA 12BGX Cluster_909314 V1282816 S helix-turn-helix, Psq domain 0ZYHB Cluster_770233 V1282817 V HNH endonuclease COG1403 Cluster_555039 V1282818 G 4-alpha-glucanotransferase COG1640 Cluster_557943 V1282819 G sugar (Glycoside-Pentoside-Hexuronide) transporter COG2211 Cluster_773925 V1282820 RSEP map04112 M Membrane-associated zinc metalloprotease COG0750 Cluster_555041 V1282824 PROTEASE map05120 O peptidase, U32 COG0826 Cluster_570255 V1282826 G Glycoside hydrolase family 76 COG4833 Cluster_555042 V1282827 S Scp-like extracellular COG2340 Cluster_828822 V1282829 S NA 0Z9EV Cluster_614503 V1282830 S DNA-binding protein COG3943 Cluster_555043 V1282831 S Iron transport-associated domain protein 0Y3IT Cluster_583061 V1282832 S NA 0YD8B Cluster_557944 V1282835 AROA map00400,map01100,map01110,map01230 E 3-phosphoshikimate 1-carboxyvinyltransferase COG0128 Cluster_555044 V1282836 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_557945 V1282837 map03420,map03430 L helicase COG0210 Cluster_555045 V1282838 M Sulfatase COG1368 Cluster_557946 V1282839 SERS map00970 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 Cluster_665872 V1282840 S Pfam:DUF2869 11WQI Cluster_589539 V1282841 OPPC P Binding-protein-dependent transport systems inner membrane component COG1173 Cluster_557948 V1282844 PUTP E SSS family proline sodium (Na ) symporter COG0591 Cluster_555047 V1282845 S Iron transport-associated domain protein 0Y3IT Cluster_573487 V1282846 K DNA-binding helix-turn-helix protein 11XIQ Cluster_555048 V1282847 DPPA map02010 E ABC transporter substrate-binding protein COG4166 Cluster_557949 V1282849 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_555049 V1282850 map02010 P ABC superfamily ATP binding cassette transporter ABC protein COG1122 Cluster_555050 V1282852 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_555051 V1282853 L NA 0YD01 Cluster_557950 V1282854 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_555052 V1282855 S Pfam:UPF0027 COG1690 Cluster_836437 V1282856 T Histidine kinase 11IN2 Cluster_555053 V1282857 HSDM V type I restriction-modification system COG0286 Cluster_570256 V1282858 V abc transporter atp-binding protein COG1131 Cluster_557951 V1282859 COBH map00860,map01100 H Precorrin-8x methylmutase COG2082 Cluster_653343 V1282861 LGT M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 Cluster_555054 V1282862 K Transcriptional regulator, ARAC family COG2207 Cluster_728453 V1282865 ACPS map00770 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) COG0736 Cluster_555056 V1282868 T crp fnr family transcriptional regulator COG0664 Cluster_557953 V1282869 ILYOP_1739 map00260,map01100 C pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_777623 V1282871 APPB map02010 P ABC transporter (Permease COG0601 Cluster_821068 V1282872 DPPC P abc transporter permease protein COG1173 Cluster_586259 V1282874 COMM O Mg chelatase subunit ChlI COG0606 Cluster_555058 V1282875 TELA P Resistance protein COG3853 Cluster_773926 V1282877 S NA 0ZYA4 Cluster_555059 V1282878 S NA 101UU Cluster_809444 V1282880 SPOVAC S Stage v sporulation protein ac 11PFY Cluster_555060 V1282882 RNC map03008,map05205 K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) COG0571 Cluster_563966 V1282883 RPLJ map03010 J 50s ribosomal protein L10 COG0244 Cluster_734971 V1282886 COBT map00860,map01100 H Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) COG2038 Cluster_555062 V1282887 ARCC map00230,map00330,map00910,map01120 E carbamate kinase COG0549 Cluster_555063 V1282888 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_555064 V1282889 P TonB-dependent receptor 0XNNV Cluster_557954 V1282890 FUCO map00620,map00630,map01120 C alcohol dehydrogenase COG1454 Cluster_679014 V1282891 map02010 G solute-binding protein 0XR78 Cluster_801258 V1282892 S NA 0XZ05 Cluster_557955 V1282893 POLC map00230,map00240,map01100,map03030,map03430,map03440 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 Cluster_557956 V1282894 E DegT/DnrJ/EryC1/StrS aminotransferase family COG0520 Cluster_555065 V1282896 S NA 101UU Cluster_653344 V1282898 GLGB map00500,map01100,map01110 G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) COG0296 Cluster_557958 V1282899 PRKC T serine threonine protein kinase COG2815 Cluster_592939 V1282901 LOLA M lipoprotein carrier protein LolA 11FJT Cluster_555066 V1282902 FTSI map00550,map01100 M Stage V sporulation protein D COG0768 Cluster_683583 V1282904 YEGQ map05120 O Peptidase U32 COG0826 Cluster_555067 V1282905 VIRD4 map03070 U TraG TraD family protein COG3505 Cluster_557959 V1282906 YADE G polysaccharide deacetylase COG0726 Cluster_579822 V1282907 L Terminase, large subunit COG4626 Cluster_557960 V1282908 O DnaJ domain protein COG0484 Cluster_557961 V1282909 S NA 101UU Cluster_702485 V1282910 LTRA L reverse transcriptase COG3344 Cluster_557962 V1282911 HBPA map02010 E Extracellular solute-binding protein, family 5 COG0747 Cluster_555069 V1282913 map02010 P ABC transporter, permease COG1175 Cluster_777624 V1282914 S NA 0Y39F Cluster_649252 V1282915 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_557963 V1282917 PTA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C phosphate acetyltransferase COG0280 Cluster_629396 V1282920 CG2937 E Extracellular solute-binding protein, family 5 COG0747 Cluster_653345 V1282923 SUSB map00052,map00500,map01100 G Alpha-glucosidase 0XNZD Cluster_793323 V1282924 PSTB map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_557965 V1282925 PPC map00620,map00680,map00710,map00720,map01100,map01120 C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) COG2352 Cluster_557966 V1282926 NDHG map00190,map00910,map01100 C NADH-ubiquinone plastoquinone oxidoreductase chain 6 1208F Cluster_557967 V1282927 map03440 K Inherit from firmNOG: Transcriptional regulator COG2865 Cluster_557968 V1282928 FBP map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120 G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 COG3855 Cluster_557969 V1282929 MSBA map02010 V ABC transporter transmembrane region COG1132 Cluster_557970 V1282930 SUA5 J sua5 ycio yrdc ywlc family protein COG0009 Cluster_557971 V1282931 M Pilin isopeptide linkage domain protein 11AV1 Cluster_557972 V1282932 V ABC transporter, ATP-binding protein COG1132 Cluster_557973 V1282933 FTSZ map04112 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 Cluster_557974 V1282934 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_758759 V1282935 AHPC O alkyl hydroperoxide reductase subunit C COG0450 Cluster_649253 V1282936 NHAC C Na H antiporter COG1757 Cluster_557975 V1282937 S NA 0ZKKG Cluster_583062 V1282938 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_758760 V1282943 NARG map00910,map01120,map02020 C nitrate reductase, alpha subunit COG5013 Cluster_905244 V1282944 NARH map00910,map01120,map02020 C nitrate reductase beta subunit COG1140 Cluster_557978 V1282948 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_557979 V1282949 TYRS map00970 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 Cluster_557980 V1282950 FUSA2 J Translation elongation factor G COG0480 Cluster_557981 V1282951 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_557982 V1282952 MUTA map00280,map00630,map00640,map00720,map01100,map01120 I Methylmalonyl-coA mutase COG1884 Cluster_805432 V1282953 T ATPase histidine kinase DNA gyrase B HSP90 domain protein COG0642 Cluster_557983 V1282956 NDVA2 V ABC transporter, ATP-binding protein COG1132 Cluster_557984 V1282957 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_557985 V1282958 S protein, conserved in bacteria COG4805 Cluster_728454 V1282962 YBED S UPF0250 protein COG2921 Cluster_696175 V1282966 FTSA D Cell Division Protein COG0849 Cluster_637280 V1282967 RPOZ map00230,map00240,map01100,map03020 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) COG1758 Cluster_557988 V1282970 S Lpxtg-motif cell wall anchor domain protein 0XQBH Cluster_557989 V1282972 PCNA map03013,map03018 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate COG0617 Cluster_557990 V1282973 S NA 11KN8 Cluster_711857 V1282974 PNTAB map00760,map01100 C transhydrogenase (subunit alpha COG3288 Cluster_557991 V1282975 M Glycosyl transferase, family 2 0ZNJT Cluster_557992 V1282976 HLYX P CBS domain protein COG1253 Cluster_557993 V1282978 NORM V Mate efflux family protein COG0534 Cluster_665873 V1282979 ARAC K transcriptional regulator (AraC 172KD@proNOG Cluster_770234 V1282980 O C-terminal, D2-small domain, of ClpB protein COG0542 Cluster_557994 V1282982 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_770235 V1282985 RPLX map03010 J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) COG0198 Cluster_641269 V1282986 COBT map00860,map01100 H Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) COG2038 Cluster_557995 V1282987 P Na Pi-cotransporter COG1283 Cluster_560987 V1282988 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_557996 V1282989 S domain protein 12C1H Cluster_557997 V1282990 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_596411 V1282991 S NA 0ZHU9 Cluster_560988 V1282992 SUN J ribosomal RNA small subunit methyltransferase COG0144 Cluster_557998 V1282993 PSTA map02010 P Phosphate ABC transporter COG0581 Cluster_567164 V1282994 CDD map00240,map00983,map01100,map05219 F cytidine deaminase COG0295 Cluster_560989 V1282995 BL01171 P hemerythrin hhe cation binding domain protein COG2461 Cluster_618262 V1282996 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_560990 V1282997 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_557999 V1282998 P Cation transporting ATPase, C-terminus COG0474 Cluster_560991 V1283000 TRMD map00900,map01100,map01110 J Specifically methylates guanosine-37 in various tRNAs (By similarity) COG0336 Cluster_560992 V1283002 PARE L DNA topoisomerase IV subunit B COG0187 Cluster_558001 V1283003 HEMZ map00860,map01100,map01110 H coproporphyrinogen III oxidase COG0635 Cluster_560993 V1283004 RPOD map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_558002 V1283006 MRDB M Rod shape-determining protein rodA COG0772 Cluster_560995 V1283007 G extracellular solute-binding protein family 1 0ZS3T Cluster_558003 V1283008 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_558004 V1283009 PURL map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_629397 V1283011 S NA 0XY3Q Cluster_560996 V1283012 YFAL M, U outer membrane autotransporter COG3468 Cluster_766526 V1283013 RNHB map03030 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0164 Cluster_567165 V1283015 YLBM S UPF0348 protein COG1323 Cluster_560997 V1283016 V abc transporter permease protein COG0577 Cluster_560998 V1283017 THIC map00730,map01100 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) COG0422 Cluster_558005 V1283018 KIPA E Allophanate hydrolase subunit 2 COG1984 Cluster_560999 V1283019 S NA 0XSXN Cluster_888373 V1283021 SACA map00052,map00500,map01100 G sucrose-6-phosphate hydrolase COG1621 Cluster_751782 V1283022 MSMX map02010 E Abc transporter, ATP-binding protein COG3839 Cluster_561001 V1283023 S NA 0ZMA4 Cluster_929188 V1283024 TOCE_0081 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_558006 V1283026 RLUB J Pseudouridine synthase COG1187 Cluster_561002 V1283027 M domain protein COG4932 Cluster_813446 V1283028 S NA 1272K Cluster_589540 V1283029 V Mate efflux family protein COG0534 Cluster_558007 V1283030 S Transcriptional regulator 11MVX Cluster_561003 V1283031 PTPA T protein tyrosine phosphatase COG0394 Cluster_561004 V1283034 G hydrolase family 2, sugar binding COG3250 Cluster_558009 V1283035 S NA 0XS0Q Cluster_561005 V1283036 COMEC S Competence protein COG2333 Cluster_793324 V1283040 MURE map00300,map00550,map01100 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0770 Cluster_558010 V1283041 FABG map00061,map00780,map01040,map01100 I reductase 0XNW1 Cluster_558011 V1283042 S (LipO)protein 0XSYT Cluster_570257 V1283044 I Diacylglycerol kinase COG1597 Cluster_614504 V1283045 E Peptidase, S9A B C family, catalytic domain protein COG1506 Cluster_561006 V1283046 L site-specific recombinase, phage integrase family COG0582 Cluster_563967 V1283049 TNAA map00380 E tryptophanase EC 4.1.99.1 COG3033 Cluster_561008 V1283050 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_586260 V1283051 MODE K Transcriptional regulator mode COG2005 Cluster_561009 V1283054 map02010 P ABC transporter 0XQHT Cluster_558012 V1283055 PURQ map00230,map01100,map01110 F Phosphoribosylformylglycinamidine synthase I COG0047 Cluster_731726 V1283056 S toxin secretion phage lysis holin 0XUV6 Cluster_637281 V1283060 MALY map00270,map00450,map00920,map01100,map01110,map01230 E Aminotransferase class I and II COG1168 Cluster_561011 V1283061 HYBC map00633,map01120 C Large subunit COG0374 Cluster_921806 V1283062 S AAA ATPase COG1373 Cluster_653346 V1283063 ISPF map00900,map01100,map01110 I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) COG1211 Cluster_561012 V1283064 ILVB map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E acetolactate synthase COG0028 Cluster_561014 V1283066 PPDK map00620,map00710,map01100,map01120 G pyruvate phosphate dikinase COG0574 Cluster_561015 V1283067 CSTA T Carbon starvation protein CstA COG1966 Cluster_561016 V1283068 HELY L helicase COG4581 Cluster_561017 V1283070 YUXL E Peptidase, S9A B C family, catalytic domain protein COG1506 Cluster_711858 V1283071 PHOR T Histidine kinase 0XNMH Cluster_561018 V1283072 C Alcohol dehydrogenase zinc-binding domain protein COG1063 Cluster_561019 V1283073 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_561020 V1283075 S Sulfite exporter TauE/SafE 0XQBF Cluster_755256 V1283077 TRXB map00240,map00450 O reductase COG0492 Cluster_586261 V1283078 MRDB map04112 M Rod shape-determining protein rodA COG0772 Cluster_758761 V1283079 HRCA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) COG1420 Cluster_653347 V1283080 P trap transporter solute receptor taxi family COG2358 Cluster_561022 V1283085 LON map04112 O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) COG0466 Cluster_561023 V1283086 THYX map00240,map00340,map00350,map00624,map00670,map01120 F Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) COG1351 Cluster_561024 V1283087 GROL map03018,map04940,map05134,map05152 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 Cluster_576693 V1283088 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_561025 V1283090 PBP2B map00550,map01100 M penicillin-binding protein COG0768 Cluster_629398 V1283091 CKL_2970 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_561026 V1283092 ADH map00010,map00051,map00071,map00350,map00362,map00363,map00591,map00620,map00621,map00622,map00625,map00626,map00630,map00650,map01100,map01110,map01120 C alcohol dehydrogenase COG1454 Cluster_683585 V1283095 YCEG F aminodeoxychorismate lyase COG1559 Cluster_561027 V1283096 L Site-specific recombinase COG1961 Cluster_567166 V1283097 CYST P binding-protein-dependent transport systems inner membrane Component COG4132 Cluster_758762 V1283098 FECD map02010 P Permease protein COG0609 Cluster_718483 V1283100 DEOB map00030,map00230 G Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) COG1015 Cluster_661665 V1283101 CPOA M Glycosyl transferase COG0438 Cluster_561028 V1283103 PRFB J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 Cluster_896613 V1283104 NTPJ P Potassium uptake protein COG0168 Cluster_738295 V1283105 KTRA P domain protein COG0569 Cluster_699452 V1283106 ARNC map00510,map00520,map01100,map01110 M Catalyzes the transfer of 4-deoxy-4-formamido-L- arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) COG0463 Cluster_561029 V1283107 PULA G Glycogen debranching enzyme COG1523 Cluster_561030 V1283108 HEMZ map00860,map01100,map01110 H coproporphyrinogen III oxidase COG0635 Cluster_561031 V1283109 YCLP map02010 P abc transporter atp-binding protein COG4604 Cluster_561032 V1283110 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_645151 V1283112 map00051 M glycosyltransferase group 2 family protein COG0463 Cluster_561033 V1283113 UUP S Abc transporter COG0488 Cluster_561034 V1283114 YNBB map00260,map00270,map00450,map01100,map01230 P aluminum resistance protein COG4100 Cluster_570258 V1283116 RNPA J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) COG0594 Cluster_561035 V1283117 S Uncharacterized BCR, YitT family COG1284 COG1284 Cluster_561036 V1283119 S general stress protein 0XVE3 Cluster_561037 V1283120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_629399 V1283121 map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120 C fumarate reductase, iron-sulfur protein COG0479 Cluster_751783 V1283122 RNPA J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) COG0594 Cluster_563969 V1283123 BCSC S cellulose synthase COG0457 Cluster_629400 V1283124 E Family 5 COG0747 Cluster_563970 V1283125 APEA map00480,map01100 E M18 family aminopeptidase COG1362 Cluster_563971 V1283127 MUTS2 map03430 L muts2 protein COG1193 Cluster_561038 V1283128 map00020,map00190,map00250,map00623,map00650,map00720,map00760,map01100,map01110,map01120,map05134 C Fumarate reductase succinate dehydrogenase flavoprotein domain-containing protein COG1053 Cluster_603519 V1283130 PTSG map00010,map00500,map00520,map02060 G PTS System COG2190 Cluster_561040 V1283131 TRXB map00240,map00450 O reductase COG0492 Cluster_583063 V1283132 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_625692 V1283134 map00052,map00500,map01100 G sucrose-6-phosphate hydrolase COG1621 Cluster_563972 V1283135 L DNA helicase COG1112 Cluster_563973 V1283136 K AraC Family Transcriptional Regulator 11KZT Cluster_696177 V1283138 CZCD P cation diffusion facilitator family transporter COG0053 Cluster_670190 V1283141 S NA 11RK5 Cluster_561042 V1283142 UGPA map02010 P binding-protein-dependent transport systems inner membrane Component COG1175 Cluster_563974 V1283143 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_661666 V1283144 L CRISPR-associated protein Csd2 COG3649 Cluster_699453 V1283145 S Protein of unknown function (DUF541) 0YM36 Cluster_563975 V1283147 COMEC S Competence protein COG2333 Cluster_561043 V1283148 S domain protein 0XPXI Cluster_705589 V1283150 HISC map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01230 E imidazole acetol-phosphate transaminase COG0079 Cluster_561044 V1283151 PURH map00230,map00670,map01100,map01110 F bifunctional purine biosynthesis protein purh COG0138 Cluster_561045 V1283152 ILVD map00290,map00770,map01100,map01110,map01210,map01230 E, G Dihydroxy-acid dehydratase COG0129 Cluster_563976 V1283153 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_589541 V1283154 S NA 0Z9TI Cluster_731727 V1283155 TDK map00240,map00983,map01100 F thymidine kinase COG1435 Cluster_563978 V1283158 UPP map00240,map01100 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) COG0035 Cluster_813447 V1283159 YAIZ S Membrane 17HMA@proNOG Cluster_603520 V1283163 P tonB-dependent Receptor 0XQJQ Cluster_561046 V1283164 S fad dependent oxidoreductase COG2509 Cluster_836439 V1283165 YHFZ S NA 173TQ@proNOG Cluster_844416 V1283166 YHFY S regulation of transcription, DNA-dependent 17HPQ@proNOG Cluster_561047 V1283167 YIDE P transport protein COG2985 Cluster_563979 V1283169 FLU M, U antigen 43 COG3468 Cluster_563980 V1283170 AMYE map02010 G solute-binding protein COG1653 Cluster_670191 V1283171 PURC map00230,map01100,map01110 F SAICAR synthetase COG0152 Cluster_563981 V1283172 MUTL map03430 L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) COG0323 Cluster_665874 V1283173 C 4Fe-4S ferredoxin, iron-sulfur binding COG1145 Cluster_561048 V1283175 YACL S PilT protein domain protein COG4956 Cluster_561049 V1283176 V ABC transporter COG1132 Cluster_561050 V1283180 FRUR K DNA-binding transcriptional regulator FruR COG1609 Cluster_563983 V1283181 HTRA map03010 O protease COG0265 Cluster_599910 V1283182 YYBT T domain protein COG3887 Cluster_625694 V1283183 S NA 0ZBRU Cluster_563984 V1283184 NTPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_657461 V1283185 MAP J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 Cluster_567167 V1283186 S (LipO)protein 0XSYT Cluster_607131 V1283187 S Endonuclease Exonuclease phosphatase 0XPGG Cluster_563985 V1283188 DEOA map00240,map00983,map01100,map05219 F The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) COG0213 Cluster_563986 V1283189 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 Cluster_561051 V1283190 map02010 P ABC transporter COG0687 Cluster_563987 V1283191 DCP E oligopeptidase A COG0339 Cluster_888375 V1283192 S protein, conserved in bacteria 11S0N Cluster_563988 V1283194 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_563989 V1283195 S Inherit from COG: pyridine nucleotide-disulfide oxidoreductase COG2210 Cluster_563990 V1283196 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_683586 V1283198 DUSB J Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_603521 V1283199 RUVC map03440 L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) COG0817 Cluster_563991 V1283202 RSMI G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 Cluster_758763 V1283209 CAS2 L CRISPR-associated protein cas2 11VHR Cluster_563992 V1283210 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_563993 V1283211 DPNA L helicase COG4646 Cluster_645152 V1283212 map02020 T Histidine kinase COG0642 Cluster_563994 V1283213 P TrkA-N domain protein COG1226 Cluster_563995 V1283214 UVRD map03420,map03430 L ATP-dependent DNA helicase pcra COG0210 Cluster_563996 V1283215 S Inherit from NOG: repeat protein 11TEE Cluster_563997 V1283216 YFIU P Drug resistance transporter, EmrB QacA subfamily 0XNN3 Cluster_579823 V1283217 S phage portal protein, SPP1 0ZZDC Cluster_563998 V1283218 S Domain of unknown function DUF87 0ZJHN Cluster_641270 V1283221 map00361,map00625,map01100,map01120 S had-superfamily hydrolase, subfamily ia, variant COG1011 Cluster_699454 V1283225 S Phage P2 GpU 1263Z Cluster_563999 V1283226 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving COG0653 Cluster_573489 V1283228 MACB map02010 V abc transporter permease protein COG0577 Cluster_564000 V1283229 S NA 0XPM9 Cluster_564001 V1283232 CLPB O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_564002 V1283233 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_896615 V1283234 S NA 0ZXYX Cluster_570259 V1283237 MEXF V AcrB AcrD family multidrug resistance protein COG0841 Cluster_570260 V1283239 YGDL H uba thif-type nad fad binding protein COG1179 Cluster_637282 V1283240 GLK G, K ROK family COG1940 Cluster_564003 V1283242 MUTS2 map03430 L muts2 protein COG1193 Cluster_564004 V1283243 CYSS map00970 J cysteinyl-tRNA synthetase COG0215 Cluster_567168 V1283244 S TIM-barrel fold 11FGY Cluster_564005 V1283245 PBP2B map00550,map01100 M penicillin-binding protein COG0768 Cluster_618264 V1283246 NAGB map00520,map01100,map01110 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COG0363 Cluster_614505 V1283247 GLGA map00500,map01100,map01110,map04973 G Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) COG0297 Cluster_567169 V1283248 METN map02010 P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COG1135 Cluster_564006 V1283249 TIG O Trigger factor COG0544 Cluster_564007 V1283250 S NA 0ZVWS Cluster_564008 V1283251 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_567170 V1283252 K Peptidase S24-like COG1974 Cluster_567171 V1283253 G domain protein 11V8D Cluster_567172 V1283257 S amidohydrolase COG1574 Cluster_844417 V1283258 RPSZ map03010 J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) COG0199 Cluster_564009 V1283259 NAPA P (Na H) antiporter COG0589 Cluster_570261 V1283261 C pyridine nucleotide-disulfide oxidoreductase family protein COG1252 Cluster_872182 V1283262 S Domain of unknown function (DUF2088) COG3875 Cluster_564011 V1283263 SITC map02010,map02020 P ABC transporter COG1108 Cluster_721783 V1283265 S Membrane COG2966 Cluster_564013 V1283267 SP_0341 S UPF0371 protein COG4868 Cluster_661668 V1283268 HOXA map02020 T Sigma-54 interaction domain protein COG2204 Cluster_567173 V1283269 map00010,map00071,map00350,map00362,map00620,map00621,map00622,map00625,map00626,map00650,map01100,map01110,map01120 C Dehydrogenase COG1454 Cluster_564014 V1283271 SPPA O, U Signal peptide peptidase, SppA COG0616 Cluster_567174 V1283272 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_583064 V1283273 S TIM-barrel fold 11FGY Cluster_567175 V1283275 YBBP Q ABC transporter, permease COG3127 Cluster_570262 V1283276 SERA map00260,map00620,map00630,map00680,map01100,map01110,map01120,map01230 C Dehydrogenase COG0111 Cluster_567176 V1283278 NRDD map00230,map00240,map01100 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 Cluster_564015 V1283279 E Extracellular solute-binding protein, family 5 COG0747 Cluster_633221 V1283280 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_567177 V1283283 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG3848 Cluster_564016 V1283284 L DNA polymerase 0XRUF Cluster_567178 V1283285 P TonB dependent receptor 0XNNV Cluster_789527 V1283287 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG1372 Cluster_564017 V1283292 HCP C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) COG1151 Cluster_567179 V1283293 S Phage infection protein COG1511 Cluster_603522 V1283294 S NA 1034D Cluster_751785 V1283296 ZWF map00030,map00480,map01100,map01110,map01120 G glucose-6-phosphate 1-dehydrogenase COG0364 Cluster_625695 V1283297 RARA L recombination factor protein RarA COG2256 Cluster_821069 V1283298 S NA 0ZHU9 Cluster_614506 V1283301 CRCB D Protein CrcB homolog COG0239 Cluster_567180 V1283302 SUFD O feS assembly protein SufD COG0719 Cluster_670193 V1283303 K RNA polymerase sigma factor 11N5G Cluster_645153 V1283304 GARA T fha domain-containing protein COG1716 Cluster_567181 V1283305 V Peptidase C39 family COG2274 Cluster_567182 V1283306 M glycosyl transferase group 1 0ZVDW Cluster_567183 V1283307 HUTH map00340,map00940,map01100 E Histidine ammonia-lyase COG2986 Cluster_564018 V1283308 S Predicted membrane protein (DUF2157) 11HGJ Cluster_567185 V1283311 HEMN map00860,map01100,map01110 C coproporphyrinogen COG0635 Cluster_567186 V1283312 map00052,map00561,map00600,map00603 G alpha-galactosidase COG3345 Cluster_741696 V1283313 ARAB map00040,map01100 G Carbohydrate kinase COG1070 Cluster_607134 V1283315 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_567187 V1283316 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_567188 V1283317 COF S Hydrolase COG0561 Cluster_567189 V1283320 S Pfam:DUF1994 0XRWZ Cluster_567190 V1283321 PRIA map03440 L Primosomal protein n' COG1198 Cluster_567191 V1283322 S Protein of unknown function (DUF1524) COG1479 Cluster_679015 V1283323 G Glycosyl hydrolase family 92 COG3537 Cluster_797288 V1283325 FPRA C domain protein COG0426 Cluster_683587 V1283327 S NA 11TWF Cluster_567192 V1283328 HEMZ map00860,map01100,map01110 H coproporphyrinogen III oxidase COG0635 Cluster_868178 V1283330 P TonB-dependent receptor Plug 0XP8A Cluster_770239 V1283331 S NA 0ZZYF Cluster_592940 V1283332 PCRA map03420,map03430 L helicase COG0210 Cluster_579824 V1283333 V abc transporter permease protein 11F1K Cluster_567193 V1283335 S Ragb susd domain-containing protein 0XPPT Cluster_657463 V1283336 PARE L Dna topoisomerase iv (Subunit b) COG0187 Cluster_567194 V1283337 S NA 0XWEM Cluster_896617 V1283339 M n-acetylmuramoyl-l-alanine amidase COG3023 Cluster_567195 V1283340 SPPA O, U Signal peptide peptidase, SppA COG0616 Cluster_832623 V1283341 L Inherit from COG: Integrase COG0582 Cluster_567196 V1283342 S Cell surface protein 0XPAZ Cluster_649254 V1283343 D ec 3.6.3.16 COG0003 Cluster_614507 V1283344 AROA map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate synthase COG0128 Cluster_567197 V1283345 S tape measure domain protein 11PSY Cluster_567199 V1283347 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_567200 V1283349 EGSA C Dehydrogenase COG0371 Cluster_567202 V1283351 SELD map00450,map01100 E Synthesizes selenophosphate from selenide and ATP (By similarity) COG0709 Cluster_567204 V1283356 PYRC map00240,map01100 F dihydroorotase COG0044 Cluster_576694 V1283357 PEP E prolyl oligopeptidase COG1505 Cluster_567206 V1283360 AROF map00400,map01100,map01110,map01230 E synthase COG2876 Cluster_567207 V1283361 S Membrane 0ZTTH Cluster_567208 V1283362 PELA G pectate lyase 0ZZUN Cluster_567209 V1283363 MUTS2 map03430 L muts2 protein COG1193 Cluster_567210 V1283364 LFERR_2229 map00680,map01100,map01120 S faD-dependent pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_567211 V1283365 NRDA map00230,map00240,map00480,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_567212 V1283366 SUFD O feS assembly protein SufD COG0719 Cluster_679016 V1283368 TAGD map00440,map00564,map01100 I, M Glycerol-3-phosphate cytidylyltransferase COG0615 Cluster_731728 V1283369 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_567213 V1283370 SCLAV_4880 map00500,map01100,map01110 G Glycogen debranching enzyme COG1523 Cluster_567214 V1283371 map00830,map00906,map01100,map01110 Q all-trans-retinol 13,14-reductase COG1233 Cluster_758764 V1283372 YAAK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) COG0718 Cluster_817176 V1283374 L SMC domain protein COG3593 Cluster_614508 V1283375 S NA 11UDA Cluster_567215 V1283376 MURA map00520,map00550,map01100 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 Cluster_567216 V1283377 NORV map05132 C domain protein COG0426 Cluster_748349 V1283378 LYSA map00260,map00270,map00300,map01100,map01110,map01120,map01230 E diaminopimelate decarboxylase COG0019 Cluster_567217 V1283379 S Plasmid recombination enzyme 0XTDI Cluster_567218 V1283380 map00260,map00670,map00910,map01100 E Aminomethyltransferase folate-binding domain 0YP69 Cluster_570264 V1283381 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_567219 V1283382 O Arginine-specific protease ArgI polyprotein 0YH82 Cluster_592941 V1283383 KTRA P domain protein COG0569 Cluster_567220 V1283384 map02010 V ABC-2 type transporter COG0842 Cluster_570265 V1283385 CDD map00240,map00983,map01100,map05219 F cytidine deaminase COG0295 Cluster_570266 V1283386 SERA map00260,map00270,map00680,map01100,map01120,map01230 E phosphoglycerate dehydrogenase COG0111 Cluster_785526 V1283387 YOEB S Addiction module toxin, Txe YoeB family COG4115 Cluster_809446 V1283389 REX K Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) COG2344 Cluster_567221 V1283390 MRCB map00550 M penicillin-binding protein COG0744 Cluster_567223 V1283392 ELI_3039 K RNA Polymerase 1261F Cluster_570267 V1283393 V ABC transporter, ATP-binding protein COG1132 Cluster_567224 V1283394 S domain protein 0XPXI Cluster_567225 V1283395 map00040,map00500,map01100 G pectinesterase (EC 3.1.1.11) COG4677 Cluster_603523 V1283396 ISDE map02010 P (ABC) transporter COG0614 Cluster_567226 V1283398 UVRD map03420,map03430 L ATP-dependent DNA helicase pcra COG0210 Cluster_567227 V1283400 LIVK map02010 E extracellular ligand-binding receptor COG0683 Cluster_596412 V1283402 CAPA M Capsule synthesis protein COG2843 Cluster_570271 V1283404 CNA M domain protein 0ZWTG Cluster_567229 V1283405 T two-component system sensor histidine kinase response regulator, hybrid 0XNMH Cluster_758765 V1283406 TRKA P potassium transporter peripheral membrane COG0569 Cluster_567230 V1283408 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_570272 V1283409 L impB/mucB/samB family C-terminal domain COG0389 Cluster_589543 V1283411 PANE map00770,map01100,map01110 H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) COG1893 Cluster_567231 V1283414 NORR map05132 K anaerobic nitric oxide reductase transcription regulator COG3604 Cluster_708662 V1283415 S NA 11VJV Cluster_570273 V1283417 T PAS domain S-box protein 0XNMH Cluster_567233 V1283420 TADA map00230,map00240,map00330,map00791,map00983,map01100,map01120 F, J deaminase COG0590 Cluster_745005 V1283422 GCVPB map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG1003 Cluster_840379 V1283425 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_570274 V1283427 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_570275 V1283428 S NA 17NWM@proNOG Cluster_567235 V1283430 GNTP E, G Gluconate COG2610 Cluster_674575 V1283431 V abc transporter permease protein COG0577 Cluster_900958 V1283432 MRED S Rod shape-determining protein MreD 1267M Cluster_848298 V1283433 MREC M Rod shape-determining protein mreC COG1792 Cluster_570276 V1283436 PEPD E Dipeptidase COG4690 Cluster_637283 V1283437 ORF5 S cytoplasmic protein 0XPUG Cluster_567238 V1283440 L Smr domain COG1193 Cluster_567239 V1283441 O Fn3-like domain (DUF1034) COG1404 Cluster_734972 V1283442 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_570277 V1283443 M outer membrane chaperone Skp (OmpH) 11PTW Cluster_570278 V1283444 ADH map00051,map00363,map00591,map00625,map00650,map01100,map01120 C alcohol dehydrogenase COG1454 Cluster_599911 V1283448 MACB2 V Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) COG1136 Cluster_641271 V1283449 K TRANSCRIPTIONAl REGULATOR GntR family COG1725 Cluster_567240 V1283450 RRMJ J Hemolysin A COG1189 Cluster_696178 V1283451 S NA 0Y9I9 Cluster_793325 V1283452 PAP L polyphosphate kinase 2 COG2326 Cluster_570279 V1283453 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_905246 V1283455 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_570280 V1283459 S Lpxtg-motif cell wall anchor domain protein 0XQBH Cluster_570281 V1283461 GLGA map00500,map01100,map01110,map04973 G Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) COG0297 Cluster_621905 V1283462 RPLB map03010 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 Cluster_770240 V1283463 S plasmid recombination enzyme 0XPM6 Cluster_570283 V1283466 P TonB dependent receptor 1AINE@sphNOG Cluster_570284 V1283467 S AAA-ATPase 0XQ4X Cluster_610780 V1283468 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_570285 V1283470 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_741697 V1283472 S NA 0ZUR0 Cluster_614509 V1283473 GALU map00040,map00052,map00500,map00520,map01100,map01110 M UTP-glucose-1-phosphate uridylyltransferase COG1210 Cluster_570286 V1283474 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_825039 V1283476 S Cell surface protein 0XPAZ Cluster_809448 V1283477 S NA 0Y1FH Cluster_721784 V1283481 WBBJ map00350,map00362,map00627,map00642,map00903,map01120 S acetyltransferase COG0110 Cluster_570288 V1283483 T ATPase histidine kinase DNA gyrase B HSP90 domain protein 0ZIAQ Cluster_570289 V1283486 RODA map00550,map04112 D cell cycle protein COG0772 Cluster_570290 V1283487 S NA 11IB6 Cluster_625696 V1283489 MLP J Lipoprotein COG2913 Cluster_570292 V1283493 HYDA map00240,map00410,map00770,map00983,map01100 F dihydropyrimidinase (EC 3.5.2.2) COG0044 Cluster_570293 V1283494 GLMM map00051,map00520,map01100,map01110 G phosphomannomutase COG1109 Cluster_570294 V1283495 RRGB M Lpxtg-motif cell wall anchor domain protein 0XSEP Cluster_570295 V1283496 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_607135 V1283498 S HhH-GPD domain protein COG5483 Cluster_570296 V1283499 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_649255 V1283500 GCTA map00643,map00650,map01120 I coenzyme A transferase COG1788 Cluster_570297 V1283501 G Major Facilitator Superfamily 11PR3 Cluster_859929 V1283502 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_859930 V1283503 YEDK S Conserved protein COG2135 Cluster_688018 V1283504 S Tetratricopeptide repeat protein 124W9 Cluster_805434 V1283505 RPME map03010 J Binds the 23S rRNA (By similarity) COG0254 Cluster_570298 V1283506 GDHA map00250,map00330,map00910,map01100 E Glutamate dehydrogenase COG0334 Cluster_570299 V1283507 S Inherit from COG: Membrane COG3949 Cluster_649256 V1283510 S NA 0ZHU9 Cluster_570300 V1283511 PYK map00010,map00230,map00620,map00710,map01100,map01110,map01120,map01230,map04930,map05203 G Pyruvate kinase COG0469 Cluster_738297 V1283512 S iron-only hydrogenase system regulator 121PF Cluster_570301 V1283514 PAAG I Enoyl-CoA hydratase COG1024 Cluster_766530 V1283515 YCGM map00350,map01100,map01120 Q fumarylacetoacetate (faa) hydrolase COG0179 Cluster_570302 V1283516 G aldose 1-epimerase COG2017 Cluster_570303 V1283517 SBCC L Exonuclease COG0419 Cluster_679017 V1283518 YIAJ K transcriptional regulator COG1414 Cluster_570304 V1283519 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_570305 V1283520 LIVM map02010 E Branched-chain amino acid ABC transporter permease protein COG4177 Cluster_825040 V1283521 DEGP map02020 O peptidase S1 and S6, chymotrypsin Hap COG0265 Cluster_570306 V1283523 PCCB map00280,map00630,map00640,map00720,map01100,map01120 I carboxyl transferase domain protein COG4799 Cluster_573491 V1283524 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_637284 V1283525 NUOH map00190,map00910,map01100 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) COG1005 Cluster_721785 V1283526 map00020,map00300,map00630,map00720,map01100,map01110,map01120,map01210,map01230 C aconitase COG1048 Cluster_832625 V1283527 PTSH G phosphocarrier protein hpr COG1925 Cluster_570307 V1283531 ASPA map00250,map00910,map01100 E Aspartate ammonia-lyase COG1027 Cluster_573492 V1283532 PHEB map00400,map01100,map01110,map01230 E Chorismate mutase COG2876 Cluster_570308 V1283533 UXUB map00040,map01100 G Mannitol dehydrogenase COG0246 Cluster_570309 V1283534 map03440 K transcriptional regulator containing an HTH domain and an COG2865 Cluster_570310 V1283535 TAGO M Glycosyl transferase, family 4 COG0472 Cluster_570313 V1283538 THIJ S intracellular protease Pfpi family COG0693 Cluster_679018 V1283539 RPLY map03010 J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) COG1825 Cluster_570315 V1283542 S Filamentation induced by cAMP protein fic COG3177 Cluster_570316 V1283543 V HNH endonuclease COG1403 Cluster_573493 V1283544 S (LipO)protein 0XQK7 Cluster_731730 V1283545 PANC map00410,map00770,map01100,map01110 H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) COG0414 Cluster_801262 V1283546 PEPQ map00310,map00780,map01100 E peptidase M24 COG0006 Cluster_633222 V1283547 HUNADC P transporter COG0471 Cluster_781447 V1283551 K HTH_XRE 17MH9@proNOG Cluster_721786 V1283552 YLQF K Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) COG1161 Cluster_573494 V1283555 UXUA map00040,map01100 G Catalyzes the dehydration of D-mannonate (By similarity) COG1312 Cluster_570319 V1283558 M YD repeat protein COG3209 Cluster_836441 V1283559 MDSC S Aminoglycoside phosphotransferase 0XP56 Cluster_570320 V1283560 BIOA map00780,map01100 H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) COG0161 Cluster_570321 V1283562 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_573495 V1283563 NAPA P (Na H) antiporter COG0589 Cluster_570323 V1283567 S NA 11NX4 Cluster_657464 V1283568 SDAAB map00260,map00270,map01100,map01110,map01230 E L-serine dehydratase, iron-sulfur-dependent, beta subunit COG1760 Cluster_657465 V1283571 POTE E Amino acid permease COG0531 Cluster_570327 V1283574 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_570328 V1283576 GCVP map00260,map01100 E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG1003 Cluster_573497 V1283577 S Phospholipase, patatin family 0YEF4 Cluster_586263 V1283579 S NA 179WB@proNOG Cluster_728457 V1283581 PKNB T Serine Threonine protein kinase COG0515 Cluster_711859 V1283583 map00260,map01100 C pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_596413 V1283584 O DnaJ domain protein COG1076 Cluster_573498 V1283586 map02010,map02030 G Periplasmic binding protein LacI transcriptional regulator COG1879 Cluster_573499 V1283587 DACA map00550,map01100 M carboxypeptidase COG1686 Cluster_751787 V1283588 RSMJ Q Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) COG0500 Cluster_573500 V1283590 S Radical SAM COG0641 Cluster_573501 V1283591 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_570329 V1283592 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_762582 V1283593 FTNA map00860 P ferritin COG1528 Cluster_781448 V1283594 GTDA map00350,map01100,map01120 Q Gentisate 1,2-dioxygenase COG3435 Cluster_859932 V1283595 FAHA map00350,map01100,map01120 Q fumarylacetoacetate (faa) hydrolase COG0179 Cluster_570330 V1283596 P tonB-dependent Receptor 0XQJQ Cluster_688019 V1283597 MOEA H Molybdenum cofactor synthesis domain protein COG0303 Cluster_570331 V1283598 C Aldo Keto reductase COG1453 Cluster_738298 V1283599 CBPA O DnaJ domain protein COG2214 Cluster_610781 V1283601 S NA 0XYKK Cluster_570332 V1283602 TRXB map00240,map00450 O thioredoxin reductase COG0492 Cluster_876300 V1283604 CSTA T carbon starvation protein COG1966 Cluster_573502 V1283606 CAS3 L CRISPR-associated helicase, cas3 COG1203 Cluster_621907 V1283607 FTNA map00860 P ferritin COG1528 Cluster_573503 V1283608 BCRA map02010 V ABC transporter COG1131 Cluster_570335 V1283610 YUFO S ABC transporter COG3845 Cluster_570336 V1283611 GLXK map00260,map00561,map00630,map01100,map01110 G Glycerate kinase COG1929 Cluster_570337 V1283612 L transposase COG3666 Cluster_711860 V1283613 S NA 0ZHU9 Cluster_721787 V1283615 P multidrug efflux COG0841 Cluster_725134 V1283617 S Domain of unknown function DUF87 0ZJHN Cluster_725135 V1283619 RMUC S Dna recombination protein COG1322 Cluster_813449 V1283620 map02010 E ABC superfamily ATP binding cassette transporter ABC protein COG3842 Cluster_614511 V1283621 RSGA G May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) COG1162 Cluster_570338 V1283622 MAEB map00620,map00710,map01100,map01120,map02020 C Malic enzyme COG0281 Cluster_738299 V1283623 FTSX map02010 D Part of the ABC transporter FtsEX involved in cellular division (By similarity) COG2177 Cluster_573505 V1283624 ATPB map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) COG1156 Cluster_570339 V1283625 PYC map00020,map00620,map00720,map01100,map01120,map01230 C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) COG1038 Cluster_573506 V1283626 S NA 11PBC Cluster_573507 V1283627 S Helix-turn-helix 0XT0B Cluster_688020 V1283628 PITA P phosphate transporter COG0306 Cluster_573508 V1283629 M Minor structural protein 0XPF3 Cluster_573509 V1283630 S NA 0XUFD Cluster_573510 V1283631 TIG O Peptidyl-prolyl cis-trans isomerase COG0545 Cluster_573512 V1283633 RARA L recombination factor protein RarA COG2256 Cluster_715223 V1283634 NUOJ map00190,map00910,map01100 C NADH dehydrogenase subunit j COG0839 Cluster_633223 V1283635 RECQ map03018 L ATP-dependent DNA helicase RecQ COG0514 Cluster_573513 V1283637 Q Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) COG1020 Cluster_573514 V1283638 YGCG S of methanol dehydrogenase type COG1512 Cluster_645154 V1283640 S NA 11KFQ Cluster_573515 V1283641 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_715224 V1283642 TRA L transposase COG2826 Cluster_573516 V1283643 M OmpA family 0YA87 Cluster_573517 V1283644 PMT M glycosyl transferase, family 39 COG1928 Cluster_573518 V1283645 S conserved protein UCP033563 0XRP0 Cluster_573519 V1283646 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_573520 V1283647 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_573521 V1283648 CADA P cadmium-exporting ATPase COG2217 Cluster_573522 V1283649 MT1736 S thiamin pyrophosphokinase catalytic COG4825 Cluster_852099 V1283650 BL00982 T head morphogenesis protein, SPP1 gp7 COG5585 Cluster_573523 V1283653 NADC map00760,map01100 H nicotinate-nucleotide pyrophosphorylase COG0157 Cluster_573524 V1283654 NRDJ map00230,map00240,map01100 F reductase COG0209 Cluster_573525 V1283656 VIRE L Virulence-associated protein e COG5545 Cluster_731731 V1283657 FOLD map00670,map00720,map01100,map01120 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 Cluster_817178 V1283658 V Mate efflux family protein COG0534 Cluster_573526 V1283659 USPA T Universal stress protein A COG0589 Cluster_674576 V1283660 AGCS E amino acid carrier protein COG1115 Cluster_573527 V1283661 BL03948 S nucleoside recognition domain protein COG3314 Cluster_573528 V1283662 S NA 188RF@proNOG Cluster_573529 V1283663 CRR map00010,map00500,map00520,map02060 G PTS System COG2190 Cluster_896620 V1283664 map00051 G Aldolase COG0235 Cluster_876301 V1283665 RSMH M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 Cluster_579825 V1283666 RECX map00561,map01100 M Glycosyl transferase (Group 1 COG0438 Cluster_599912 V1283667 map02010 E (ABC) transporter COG4608 Cluster_573530 V1283668 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_683588 V1283669 I Phosphoesterase, PA-phosphatase related COG0671 Cluster_573531 V1283670 SERP0565 L transposase IS116 IS110 IS902 family protein COG3547 Cluster_573533 V1283672 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_573534 V1283673 map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) COG1156 Cluster_573535 V1283674 WECG M Glycosyl transferase, wecb taga cpsf family COG1922 Cluster_573536 V1283675 PITA P phosphate transporter COG0306 Cluster_573537 V1283678 UPPP map00550 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) COG1968 Cluster_801263 V1283680 HUTI map00340,map01100 Q imidazolone-5-propionate hydrolase COG1228 Cluster_679020 V1283681 L adenine specific DNA methyltransferase COG4889 Cluster_576695 V1283682 V Mate efflux family protein COG0534 Cluster_731732 V1283684 GLTA map00250,map00910,map01100,map01110,map01120,map01230 E Glutamate synthase COG0543 Cluster_777628 V1283685 S integral membrane protein 11P1U Cluster_758767 V1283688 HUTU map00340,map01100 E Urocanate hydratase COG2987 Cluster_576696 V1283689 S ErfK YbiS YcfS YnhG COG1376 Cluster_721788 V1283691 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_770241 V1283693 COMM O Mg chelatase subunit ChlI COG0606 Cluster_855876 V1283694 O AhpC Tsa family 0YT1V Cluster_573540 V1283696 DEF J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) COG0242 Cluster_708664 V1283703 RPSD map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) COG0522 Cluster_573543 V1283704 S transporter gate domain protein 0XRV8 Cluster_573545 V1283706 P tonB-dependent Receptor 0XQJQ Cluster_579826 V1283707 S secreted protein 0XSCU Cluster_621908 V1283708 SA0315 K SIR2 family COG0846 Cluster_573546 V1283710 CLPB O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_576698 V1283712 map00564,map00730 C fad dependent oxidoreductase COG0579 Cluster_583066 V1283716 D Chromosome Partitioning Protein COG1192 Cluster_573547 V1283717 PBP2B map00550,map01100 M penicillin-binding protein COG0768 Cluster_633224 V1283718 ATPA map00190,map00195,map01100,map04610,map05202 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_661670 V1283719 ARGH map00250,map00330,map01100,map01110,map01230 E arginosuccinase COG0165 Cluster_573548 V1283721 S phage portal protein HK97 family COG4695 Cluster_573549 V1283722 M Export protein COG1596 Cluster_576699 V1283723 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_576700 V1283725 I Phospholipase, patatin family COG4667 Cluster_748353 V1283726 V Type I restriction-modification system R subunit COG4096 Cluster_576702 V1283728 POTC map02010 P putrescine abc transporter COG1177 Cluster_579827 V1283729 LSRB map02010 G ABC, transporter 173S8@proNOG Cluster_576703 V1283731 P tonB-dependent Receptor 0XQNF Cluster_573550 V1283732 SUHB map00521,map00562,map00920,map01100,map01110,map01120,map04070 G inositol monophosphatase COG0483 Cluster_576704 V1283733 GLYS map00970 J Glycyl-tRNA synthetase beta subunit COG0751 Cluster_573551 V1283735 map00300,map01100,map01110,map01120,map01230 E, M Dihydrodipicolinate synthase COG0329 Cluster_576706 V1283736 V ABC transporter, permease protein 0XP9H Cluster_573552 V1283738 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_573553 V1283739 DNAD L DNA replication protein DnaD COG3935 Cluster_653348 V1283740 RPLX map03010 J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) COG0198 Cluster_576708 V1283741 S conjugation system ATPase, TraG family 0XSHU Cluster_909317 V1283743 YAGR map00230,map00450,map01100,map01120 C Xanthine dehydrogenase COG1529 Cluster_738301 V1283744 YAGQ O XdhC and CoxI family COG1975 Cluster_576710 V1283745 WECB map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_576711 V1283746 ARC map03050 O ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) COG0464 Cluster_576712 V1283747 YQFO S dinuclear metal center protein, YbgI family COG3323 Cluster_670194 V1283748 OBG C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 Cluster_573554 V1283749 T CRP FNR family transcriptional regulator COG0664 Cluster_576713 V1283750 YXCA I coA-substrate-specific enzyme activase COG3581 Cluster_576714 V1283751 IDH S oxidoreductase 16SP3@proNOG Cluster_576715 V1283752 RLMI S Methyltransferase COG1092 Cluster_576716 V1283753 MT1053 D Septum formation initiator family protein COG1507 Cluster_573555 V1283754 CAS3 L CRISPR-associated helicase, cas3 COG1203 Cluster_576717 V1283755 CELA map00010 G 6-phospho-beta-glucosidase (EC 3.2.1.86) COG2723 Cluster_573556 V1283756 map02010 P Periplasmic binding protein 0XRC7 Cluster_718485 V1283757 YQEY S gatB Yqey COG1610 Cluster_576718 V1283758 FABF map00061,map00780,map01100 I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) COG0304 Cluster_633225 V1283759 MDH map00020,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120 C Malate dehydrogenase COG0039 Cluster_573558 V1283764 S NurA domain protein 11IQE Cluster_573559 V1283765 UXUB map00040,map01100 G Mannitol dehydrogenase COG0246 Cluster_573560 V1283766 CBIK map00860,map01100 H cobalt chelatase COG4822 Cluster_573561 V1283767 CADA P p-type atpase COG2217 Cluster_645155 V1283769 NNR K Transcriptional regulator, Crp Fnr family COG0664 Cluster_715225 V1283770 S NA 0XT3G Cluster_576720 V1283771 CITX map02020 H, I holo-ACP synthase CitX COG3697 Cluster_692438 V1283772 ARSM S Methyltransferase 0XSKB Cluster_725137 V1283773 HLYX P CBS domain protein COG1253 Cluster_679021 V1283776 PRFA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) COG0216 Cluster_576721 V1283777 YBER S Protein of unknown function (DUF1266) 17SVD@proNOG Cluster_793326 V1283778 S PTS HPr component phosphorylation site 0Z2NZ Cluster_576722 V1283779 S UPF0597 protein COG3681 Cluster_576723 V1283781 FABF3 map00061,map00780,map01100 I, Q synthase COG0304 Cluster_576724 V1283782 ARGF map00330,map01100,map01110,map01230 E ornithine carbamoyltransferase COG0078 Cluster_618265 V1283783 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_576725 V1283784 RECG map03440 L ATP-dependent DNA helicase recG COG1200 Cluster_576726 V1283787 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_576727 V1283788 G sugar (Glycoside-Pentoside-Hexuronide) transporter COG2211 Cluster_576728 V1283789 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_586265 V1283790 MREB D Rod shape-determining protein mreb COG1077 Cluster_728458 V1283791 PEPC E aminopeptidase c COG3579 Cluster_576729 V1283792 SP_0341 S UPF0371 protein COG4868 Cluster_586266 V1283793 S NA 0XPM9 Cluster_576730 V1283794 LIVK map02010 E extracellular ligand-binding receptor COG0683 Cluster_576731 V1283795 YAIS S lmbE family COG2120 Cluster_576732 V1283796 NUC L nuclease COG1525 Cluster_576733 V1283797 ISPG map00900,map01100,map01110 I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) COG0821 Cluster_649257 V1283798 CYDC map02010 V ABC transporter transmembrane region COG4988 Cluster_905250 V1283799 S NA 11FZQ Cluster_817179 V1283800 S conjugative transposon membrane protein 0XPC1 Cluster_548334 V1028203 SECD map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) COG0342 Cluster_920518 V1028204 YIHV map00030,map00051,map01100 G sugar kinase 174EF@proNOG Cluster_895443 V1028205 MMSB map00280,map00630,map01100 I 3-hydroxyisobutyrate dehydrogenase COG2084 Cluster_548335 V1028206 OCAR_6752 H DNA integration recombination invertion protein COG1636 Cluster_598871 V1028207 HADH2 S Dehydrogenase 0XNNW Cluster_548337 V1028209 S UPF0637 protein COG4493 Cluster_548338 V1028214 S Membrane 12317 Cluster_548339 V1028217 ATPD map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 Cluster_548340 V1028218 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_548341 V1028219 BMUL_3200 P tonb-dependent siderophore receptor COG1629 Cluster_548342 V1028220 PLPD S Patatin-like phospholipase COG1752 Cluster_808264 V1028222 RFBA map00521,map00523,map01100,map01110 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) COG1209 Cluster_812275 V1028223 RFBD map00521,map00523,map01100,map01110 M Dtdp-4-dehydrorhamnose reductase COG1091 Cluster_551279 V1028226 CSHB map03018 L RNA helicase COG0513 Cluster_551280 V1028227 FUSA J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 Cluster_566178 V1028228 L NA 11GDS Cluster_548343 V1028229 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_551281 V1028230 SFNA I acyl-Coa dehydrogenase 16RDR@proNOG Cluster_551284 V1028238 YCHF J gtp-binding protein COG0012 Cluster_652033 V1028241 S NA 17MBT@proNOG Cluster_551285 V1028242 KDPA map02020 P One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) COG2060 Cluster_730772 V1028246 ACPP2 I, Q Acyl carrier protein COG0236 Cluster_720816 V1028248 C Alcohol dehydrogenase zinc-binding domain protein COG0604 Cluster_551287 V1028252 K Tetr family transcriptional regulator 11SFF Cluster_551288 V1028253 S NA 0YCC9 Cluster_643926 V1028255 BL05015 S UPF0276 protein COG3220 Cluster_605968 V1028256 S NA 186D0@proNOG Cluster_730773 V1028259 map00363,map00624,map00627,map00903,map00945,map01100,map01110,map01120 C Cytochrome P450 0YEWW Cluster_780154 V1028261 K transcriptional regulator AsnC family COG1522 Cluster_551289 V1028262 IDI map00900,map01100,map01110 I Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) COG1443 Cluster_707797 V1028263 BMUL_6126 K LysR family transcriptional regulator 16SPU@proNOG Cluster_551290 V1028267 GALU map00040,map00052,map00500,map00520,map01100,map01110 M UTP-glucose-1-phosphate uridylyltransferase COG1210 Cluster_839064 V1028268 YBAY S Glycoprotein polysaccharide metabolism COG3126 Cluster_858530 V1028271 METQ map02010 P (Lipo)protein COG1464 Cluster_551291 V1028272 AGUB map00330,map01100 S hydrolase, carbon-nitrogen family COG0388 Cluster_569281 V1028274 PDHD map00010,map00020,map00260,map00280,map00620,map01100,map01110,map01120 C dihydrolipoyl dehydrogenase COG1249 Cluster_551292 V1028276 S Hydrolase COG0561 Cluster_551294 V1028279 SBCB map03430 L Exodeoxyribonuclease I COG2925 Cluster_664558 V1028280 UVRA2 map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_551295 V1028281 KDPD map02020 T Osmosensitive K channel His kinase sensor COG2205 Cluster_551296 V1028283 K transcriptional regulator COG1414 Cluster_691208 V1028284 SSCG_03030 map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_647936 V1028287 CORA P magnesium and cobalt transport protein CorA COG0598 Cluster_551297 V1028290 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_724186 V1028293 MT0828 S NA 11U2D Cluster_730775 V1028298 map02010 E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COG3842 Cluster_908234 V1028299 GABT map00250,map00280,map00310,map00410,map00640,map00650,map01100 E 4-aminobutyrate aminotransferase COG0160 Cluster_591879 V1028300 BMUL_0952 K Tetr family transcriptional regulator 179IA@proNOG Cluster_554140 V1028301 PROY E amino acid COG1113 Cluster_551299 V1028303 YGGP S Rhomboid family COG0705 Cluster_554141 V1028304 PROC map00330,map01100,map01110,map01230 E pyrroline-5-carboxylate reductase COG0345 Cluster_602334 V1028305 BDAG_03195 K Transcriptional regulator, TraR DksA family 17QCW@proNOG Cluster_784383 V1028310 YBAB S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) COG0718 Cluster_554142 V1028311 G Major Facilitator 0XQHZ Cluster_551300 V1028312 AMSD M glycosyl transferase group 1 COG0438 Cluster_554143 V1028313 L UvrD REP helicase COG0210 Cluster_554144 V1028314 XDHB map00230,map01100,map01120 F Xanthine dehydrogenase COG4631 Cluster_551301 V1028315 THIC map00730,map01100 H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) COG0422 Cluster_698544 V1028316 PROC map00330,map01100,map01110,map01230 E pyrroline-5-carboxylate reductase COG0345 Cluster_609638 V1028317 RPE map00030,map00040,map00710,map01100,map01110,map01120,map01230 G ribulose-phosphate 3-epimerase COG0036 Cluster_554145 V1028319 VDH map00622,map00623,map00627,map01100,map01120,map01220 C Acyl-CoA reductase (LuxC) COG1012 Cluster_554146 V1028321 S Vitamin K epoxide reductase COG4243 Cluster_554147 V1028323 YDIJ map00620,map00630,map01100,map01110,map01120 C Oxidoreductase COG0277 Cluster_560089 V1028325 BADA map00627,map01120 Q amp-dependent synthetase and ligase COG0365 Cluster_554150 V1028328 ASPC map00250,map00290,map01100,map01110,map01210,map01230 E Aminotransferase COG0436 Cluster_554151 V1028330 BMUL_3441 O Peptidase S53 propeptide COG4934 Cluster_554152 V1028332 MDTM G Multidrug resistance protein MdtM 16TV2@proNOG Cluster_554153 V1028334 M, U Inherit from COG: Outer membrane autotransporter COG3468 Cluster_554154 V1028339 YCHM P sulfate transporter COG0659 Cluster_554155 V1028341 LPDA map00010,map00020,map00260,map00280,map00480,map00620,map01100,map01110,map01120 C mercuric reductase COG1249 Cluster_554156 V1028342 map02010 G (ABC) transporter COG3839 Cluster_554157 V1028343 P Domain of unknown function DUF21 COG4536 Cluster_557034 V1028353 S Spherulation-specific family 4 17QTA@proNOG Cluster_847199 V1028356 PSTS map02010,map02020,map05152 P Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) COG0226 Cluster_554158 V1028357 PRFC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) COG4108 Cluster_557035 V1028359 HSDM V type I restriction-modification system COG0286 Cluster_588505 V1028361 HSLU O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) COG1220 Cluster_554159 V1028365 SDHA map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020,map05134 C succinate dehydrogenase, flavoprotein subunit COG1053 Cluster_554160 V1028369 ADHC map00010,map00561,map00930,map01100,map01110,map01120 C alcohol dehydrogenase COG1064 Cluster_557036 V1028370 GLYA map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01230 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) COG0112 Cluster_557037 V1028371 YEEA V methylase COG1002 Cluster_613297 V1028374 OPUCD map02010 E Glycine betaine carnitine choline COG1174 Cluster_788425 V1028375 S Protein of unknown function (DUF330) COG3009 Cluster_831353 V1028376 map00300,map01100,map01210,map01230 K Transcriptional regulator COG1167 Cluster_557038 V1028377 XYLE map04113 G transporter 16TAE@proNOG Cluster_557039 V1028378 UREC map00230,map00330,map00791,map01100,map01120,map05120 E Urea amidohydrolase subunit alpha COG0804 Cluster_557040 V1028381 PILB map03070 U type II secretion system protein E COG2804 Cluster_870966 V1028384 S NA 0ZHU9 Cluster_883271 V1028385 map02010 E Inner-membrane translocator COG0559 Cluster_720817 V1028386 map02010 E ABC, transporter COG4177 Cluster_554162 V1028387 map00030,map00040,map01100,map01110,map01120 G xylulokinase (EC 2.7.1.17) COG1070 Cluster_554163 V1028388 WECC map00051,map00363,map00520,map00591,map00625,map00650,map01100,map01120 M Dehydrogenase COG0677 Cluster_743968 V1028390 M NA 100GX Cluster_557042 V1028392 BMUL_2867 map00310,map00780,map01100 S peptidase m61 COG3975 Cluster_557043 V1028395 Y2188 S Host specificity protein COG4733 Cluster_578792 V1028396 CMTA S Trehalose corynomycolyl transferase COG0627 Cluster_557044 V1028397 LGAS_0606 S Phage Portal Protein 0XP33 Cluster_554165 V1028398 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_554166 V1028399 T histidine Kinase 16PBK@proNOG Cluster_777629 V1283801 S NA 0ZHU9 Cluster_579828 V1283802 PTSI map00051,map01100,map02060 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) COG3412 Cluster_649258 V1283803 MACB map02010 V abc transporter permease protein COG0577 Cluster_576734 V1283804 VSAL_I0171 E DegT/DnrJ/EryC1/StrS aminotransferase family COG0399 Cluster_576738 V1283810 RECQ map03018 L ATP-dependent DNA helicase RecQ COG0514 Cluster_576739 V1283811 V abc transporter permease protein 0XQE2 Cluster_641273 V1283812 YAAT S psp1 domain protein COG1774 Cluster_576740 V1283815 S DNA polymerase iii 101FB Cluster_576741 V1283816 ARCD S c4-dicarboxylate anaerobic carrier COG1288 Cluster_633226 V1283818 S Pfam:DUF567 COG4894 Cluster_755258 V1283819 S NA 12BR4 Cluster_576744 V1283822 CG2284 C uridylyltransferase COG1085 Cluster_576745 V1283823 M domain protein COG4932 Cluster_576746 V1283825 V Efflux ABC transporter, permease protein 0XPE8 Cluster_579829 V1283827 SPOIID D SpoIID LytB domain protein COG2385 Cluster_576748 V1283828 DNAB map03030,map04112 L Replicative dna helicase COG0305 Cluster_576749 V1283831 RIBE map00740,map01100 H riboflavin synthase, subunit alpha COG0307 Cluster_576750 V1283832 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_579830 V1283833 S NA 0Y4VZ Cluster_576751 V1283834 LGAS_0607 T head morphogenesis protein, SPP1 gp7 COG5585 Cluster_579831 V1283836 APPB P Binding-protein-dependent transport systems, inner membrane component COG0601 Cluster_576752 V1283837 ATPA map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity) COG1155 Cluster_645156 V1283838 Y0750 S Conserved Protein COG3586 Cluster_579832 V1283839 ISPH map00900,map01100,map01110,map03010 I Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) COG0761 Cluster_576753 V1283840 ARGD map00300,map00330,map01100,map01110,map01120,map01210,map01230 E Acetylornithine aminotransferase COG4992 Cluster_576754 V1283842 LPXK map00540,map01100 M Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) COG1663 Cluster_576755 V1283844 PANC map00410,map00770,map01100,map01110 H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) COG0414 Cluster_576756 V1283845 CSTA T carbon starvation protein COG1966 Cluster_859934 V1283848 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_821074 V1283849 S NA 0Y0JF Cluster_813450 V1283850 S Inherit from NOG: Plasmid segregation actin-type ATPase ParM 0XQMS Cluster_579833 V1283852 SRTB U sortase, SrtB family COG4509 Cluster_579834 V1283853 Q amino acid adenylation domain protein COG1020 Cluster_579835 V1283854 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_715227 V1283855 AGCS E amino acid carrier protein COG1115 Cluster_674577 V1283857 J Glutamine amidotransferase COG2355 Cluster_579836 V1283858 O Peptidase family M48 COG0501 Cluster_699455 V1283860 S Uncharacterized protein conserved in bacteria (DUF2179) COG1284 Cluster_813451 V1283862 LEPB map03060 U Signal peptidase i COG0681 Cluster_836443 V1283863 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_576760 V1283864 RBSR K Transcriptional regulator COG1609 Cluster_576761 V1283865 BL03948 S nucleoside recognition domain protein COG3314 Cluster_579837 V1283867 S Toxin-antitoxin system, toxin component, RelE family COG4679 Cluster_864237 V1283868 map00230,map01100 F guanylate kinase COG0194 Cluster_859935 V1283869 HOLB map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG2812 Cluster_576762 V1283870 INTQ L Integrase COG0582 Cluster_725138 V1283871 METN map02010 P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COG1135 Cluster_579838 V1283872 S NA 0XR9X Cluster_576763 V1283873 CNA M domain protein 0ZWTG Cluster_579839 V1283874 S ATPase (AAA COG1373 Cluster_576764 V1283875 M NA 0ZTFU Cluster_579841 V1283877 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_741698 V1283879 COAE map00770,map01100 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 Cluster_576765 V1283880 YJHA S Endonuclease Exonuclease phosphatase 0XNVA Cluster_579842 V1283881 YEBC K transcriptional regulatory protein COG0217 Cluster_629404 V1283883 IDER K iron (metal) dependent repressor, dtxr family COG1321 Cluster_848299 V1283884 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_621909 V1283885 S YitT family COG1284 Cluster_576766 V1283886 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_579843 V1283887 POLA map00230,map00240,map01100,map03030,map03410,map03420,map03440 L dna polymerase I COG0749 Cluster_781450 V1283888 PEPC E aminopeptidase c COG3579 Cluster_579844 V1283889 S (Histidine triad) protein 11RAF Cluster_576767 V1283890 S SusD family 103XH Cluster_813452 V1283892 S (LipO)protein 0XSFR Cluster_579845 V1283893 CLPP map04112 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 Cluster_741699 V1283894 P Transporter COG0733 Cluster_576768 V1283897 HYDF S gtp-binding protein COG1160 Cluster_579846 V1283898 S membrAne COG1284 Cluster_855878 V1283899 map01040 E lipolytic protein G-D-S-L family COG2755 Cluster_579847 V1283901 PYRG map00240,map01100 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 Cluster_614512 V1283902 map00010 G Glycosyl hydrolase, family 1 COG2723 Cluster_579848 V1283903 S SusD family 0YA6Q Cluster_773930 V1283904 RSMC J methyltransferase COG2813 Cluster_579849 V1283907 O Peptidyl-prolyl cis-trans isomerase COG0760 Cluster_579850 V1283908 XYNB I esterase COG0657 Cluster_649259 V1283909 CYDC map02010 V Abc transporter COG1132 Cluster_657466 V1283911 P tonB-dependent Receptor 0XNN9 Cluster_718486 V1283913 PKND E ABC transporter substrate-binding protein COG0834 Cluster_758768 V1283914 PG0188 S BNR Asp-box repeat protein 11U9Y Cluster_637285 V1283917 map02010 V ABC transporter transmembrane region COG1132 Cluster_579852 V1283918 ICMF map03070 M Type VI secretion protein IcmF COG3523 Cluster_773931 V1283919 MUTS2 map03430 L muts2 protein COG1193 Cluster_762583 V1283921 FUR P Ferric uptake COG0735 Cluster_868180 V1283922 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_718487 V1283923 S Putative ATPase subunit of terminase (gpP-like) 0Z1RP Cluster_715228 V1283924 XPT map00230,map01100,map01110 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) COG0503 Cluster_579853 V1283925 FBA map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01230 G Fructose-bisphosphate aldolase class-II COG0191 Cluster_738302 V1283926 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_579854 V1283927 P TonB-dependent Receptor Plug 0XNNV Cluster_579855 V1283928 BAS0367 map02010 P Binding-protein-dependent transport systems, inner membrane component COG0600 Cluster_579856 V1283929 S NA 0ZCA8 Cluster_579857 V1283931 GLPF G Major Intrinsic Protein COG0580 Cluster_579858 V1283932 TRPB map00260,map00400,map01100,map01110,map01230 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) COG0133 Cluster_583068 V1283933 L Terminase, large subunit COG4626 Cluster_579859 V1283934 ARGR K Regulates arginine biosynthesis genes (By similarity) COG1438 Cluster_579860 V1283935 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_579861 V1283936 SP_1221 V restriction 0XQ8K Cluster_579862 V1283937 LYSA map00300,map01100,map01110,map01120,map01230 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) COG0019 Cluster_579863 V1283938 T Histidine kinase COG0642 Cluster_579865 V1283940 SUN map00340,map00350,map00624,map01120 J NOL1 NOP2 sun family protein COG3270 Cluster_579866 V1283941 CYDD map02010 V ABC, transporter COG4988 Cluster_731734 V1283943 ILVB map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E Acetolactate synthase, large subunit COG0028 Cluster_579867 V1283944 K transcriptional regulator COG1609 Cluster_661672 V1283946 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_579868 V1283947 MUTL2 map00660,map01100 S glutamate mutase, mutL 0XRSI Cluster_725139 V1283950 YCLM map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Aspartokinase COG0527 Cluster_579869 V1283951 AROC map00400,map01100,map01110,map01230 E 5-enolpyruvylshikimate-3-phosphate phospholyase COG0082 Cluster_579870 V1283953 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_579871 V1283955 map03070,map04626,map05133 M Outer membrane efflux protein COG1538 Cluster_670196 V1283956 YQEG V had superfamily (subfamily IIIa) phosphatase COG2179 Cluster_579872 V1283958 AHPC O alkyl hydroperoxide reductase COG0450 Cluster_583069 V1283961 map05152 T Protein tyrosine kinase COG0515 Cluster_579874 V1283962 L Recombinase COG1961 Cluster_579875 V1283964 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_579876 V1283965 L Dead deah box helicase domain protein COG4581 Cluster_583070 V1283966 NIFS map00450,map00730,map01100,map04122 E Cysteine desulfurase COG0520 Cluster_579877 V1283967 VANW V VanW family COG2720 Cluster_579878 V1283969 FLDA map00960 C L-carnitine dehydratase bile acid-inducible protein F COG1804 Cluster_583071 V1283971 L Replication initiation factor COG2946 Cluster_579880 V1283972 P TonB-dependent receptor 0XNNV Cluster_583072 V1283973 map02010 V ABC-2 type transporter COG0842 Cluster_579881 V1283974 YJBF S SNARE-like domain protein COG0398 Cluster_699456 V1283977 ARSC P Transcriptional regulator, Spx MgsR family COG1393 Cluster_579882 V1283979 V permease 0YATZ Cluster_583073 V1283980 M Glycosyl transferase family 2 0ZX2Q Cluster_766532 V1283985 L Pfam:Transposase_17 COG1943 Cluster_583074 V1283986 BIRA map00780,map01100 H Biotin- acetyl-CoA-carboxylase ligase COG0340 Cluster_583075 V1283987 ATPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_745007 V1283988 RNC map03008,map05205 K Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) COG0571 Cluster_825043 V1283989 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_741701 V1283990 S Protein of unknown function (DUF3027) 0YV7T Cluster_781451 V1283991 S NA 0XUUN Cluster_583076 V1283993 S DNA-binding protein 127Q2 Cluster_603524 V1283994 TOPA L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 Cluster_579884 V1284000 RLUD J Pseudouridine synthase COG0564 Cluster_629405 V1284002 map03430 L Adenine-specific COG3392 Cluster_793327 V1284003 LEPB map03060 U Signal peptidase I COG0681 Cluster_844418 V1284004 DAPB map00300,map01100,map01110,map01120,map01230 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) COG0289 Cluster_583077 V1284005 GLNP E ABC transporter (Permease) COG0765 Cluster_579885 V1284006 AGCS E amino acid carrier protein COG1115 Cluster_741702 V1284007 HPT map00230,map00983,map01100,map01110 F hypoxanthine phosphoribosyltransferase COG0634 Cluster_583079 V1284010 URAA F permease COG2233 Cluster_583080 V1284011 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_583081 V1284012 S phospholipase COG4667 Cluster_665876 V1284014 M Cell wall anchor domain protein 129AF Cluster_583082 V1284015 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_579886 V1284016 HYPE O hydrogenase expression formation protein (HypE) COG0309 Cluster_579887 V1284017 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_583083 V1284022 ASPS map00970 J aspartyl-trna synthetase COG0173 Cluster_583084 V1284023 G Bacterial group 2 Ig-like protein COG5492 Cluster_579888 V1284024 V ABC transporter transmembrane region COG1132 Cluster_579889 V1284025 S NA 0YESD Cluster_896621 V1284026 TUSE map04122 P Part of a sulfur-relay system (By similarity) COG2920 Cluster_579890 V1284027 DPP map04974 E peptidase COG1506 Cluster_696180 V1284029 YEAO S MarR family Transcriptional regulator COG3189 Cluster_583085 V1284030 RPSE map03010 J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) COG0098 Cluster_755260 V1284031 S NA 0Z20Q Cluster_579891 V1284034 HOXA map02020 T Bacterial regulatory protein, Fis family COG2204 Cluster_599913 V1284035 C Rubrerythrin COG1592 Cluster_583086 V1284036 PRIA map03440 L Primosomal protein n' COG1198 Cluster_618267 V1284038 DEOA map00240,map00983,map01100,map05219 F The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) COG0213 Cluster_583088 V1284039 C Binding Domain protein COG0348 Cluster_579892 V1284040 S NA 0ZWDS Cluster_725140 V1284041 RPLU map03010 J This protein binds to 23S rRNA in the presence of protein L20 (By similarity) COG0261 Cluster_583089 V1284042 V Efflux ABC transporter, permease protein COG0577 Cluster_603526 V1284043 S X-X-X-Leu-X-X-Gly heptad repeats COG1511 Cluster_583090 V1284044 GNTR K TRANSCRIPTIONAl REGULATOR GntR family COG1725 Cluster_583091 V1284045 HYDC map00190,map00910,map01100 C -hydrogenase COG4624 Cluster_583092 V1284046 GLNA map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG0174 Cluster_583093 V1284047 YECC map02010 E abc transporter atp-binding protein COG1126 Cluster_583095 V1284049 map00230,map00250,map01100,map01110 F Glutamine phosphoribosylpyrophosphate amidotransferase COG0034 Cluster_579893 V1284050 MCSA S Uvrb UvrC protein COG3880 Cluster_583096 V1284051 ALAS map00970 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 Cluster_589544 V1284052 PUUR K Transcriptional regulator COG1396 Cluster_583097 V1284053 M efflux transporter, outer membrane factor lipoprotein, NodT family COG1538 Cluster_579894 V1284054 YOJN S ATPase associated with various cellular activities aaa_5 COG0714 Cluster_649260 V1284055 map02010 P ABC transporter COG0395 Cluster_579895 V1284056 CTPC map00190 P heavy metal translocating p-type ATPase COG2217 Cluster_583098 V1284057 GLTA map00020,map00630,map00640,map01100,map01110,map01120,map01210,map01230 C citrate synthase COG0372 Cluster_583099 V1284058 MNME S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 Cluster_692441 V1284059 L Integrase COG0582 Cluster_583101 V1284061 G fg-gap repeat protein 0XPAI Cluster_583102 V1284062 PTRB map05142,map05143 E Oligopeptidase b COG1770 Cluster_618268 V1284063 S HD Domain 11NW5 Cluster_696181 V1284065 S NA 11QVU Cluster_583103 V1284066 S relaxase Mobilization nuclease 0YE2V Cluster_583105 V1284071 P tonB-dependent Receptor COG4771 Cluster_583106 V1284073 APEA map00480,map01100 E M18 family aminopeptidase COG1362 Cluster_583108 V1284075 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_583109 V1284076 L Replication initiation and membrane attachment COG3935 Cluster_583110 V1284077 GLGC map00500,map00520,map01100,map01110 G Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) COG0448 Cluster_583111 V1284078 TELA P Resistance protein COG3853 Cluster_583112 V1284079 S NA 0XZ3T Cluster_583113 V1284080 PPK map00190,map03018 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) COG0855 Cluster_905251 V1284081 S NUDIX domain 0ZM1E Cluster_583114 V1284082 N Cell surface protein 1CAVF@tenNOG Cluster_929195 V1284084 RPSB map03010 J 30S ribosomal protein S2 COG0052 Cluster_583116 V1284085 G Aldose 1-epimerase COG2017 Cluster_583117 V1284088 LACZ map00052,map00511,map00600,map01100 G beta galactosidase small chain COG3250 Cluster_583118 V1284089 ARGK E lAO AO transport system ATPase COG1703 Cluster_583119 V1284090 DPP map04974 E peptidase COG1506 Cluster_607138 V1284091 RPE map00030,map00040,map00710,map01100,map01110,map01120,map01230 G ribulose-phosphate 3-epimerase COG0036 Cluster_621910 V1284092 ATU2672 S ABC transporter COG2984 Cluster_583120 V1284093 DPPC map02010 P abc transporter, permease COG1173 Cluster_583122 V1284095 PRFA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) COG0216 Cluster_583123 V1284097 VPA1266 map03440 L Helicase, RecD TraA family COG4932 Cluster_583124 V1284098 V Mate efflux family protein COG0534 Cluster_683590 V1284100 DPPB P ABC transporter (Permease COG0601 Cluster_583127 V1284102 S ragb susd domaiN-containing protein 0Z7X3 Cluster_583128 V1284103 ENGB S Necessary for normal cell division and for the maintenance of normal septation (By similarity) COG0218 Cluster_583129 V1284104 map00520 G n-acylglucosamine 2-epimerase COG2942 Cluster_583130 V1284105 RFBB map00521,map00523,map01055,map01100,map01110 M dtdp-glucose 4,6-dehydratase COG1088 Cluster_583131 V1284106 SG1670 S phage protein COG3646 Cluster_583132 V1284107 RLX U relaxase mobilization nuclease domain protein COG3843 Cluster_583133 V1284108 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_583134 V1284109 L Inherit from COG: Integrase COG0582 Cluster_583135 V1284110 S NA 0ZWQU Cluster_583136 V1284111 TRAI L TrwC protein COG0507 Cluster_583137 V1284112 FTNA map00860 P ferritin COG1528 Cluster_629406 V1284114 PURC map00230,map01100,map01110 F SAICAR synthetase COG0152 Cluster_583139 V1284115 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_583140 V1284116 CAPA M Capsule synthesis protein COG2843 Cluster_583141 V1284119 FHUA P receptor COG1629 Cluster_583142 V1284120 map00360 E Peptidase dimerisation domain COG1473 Cluster_583143 V1284121 G Xylose isomerase domain protein TIM barrel 0ZVDG Cluster_583144 V1284123 S Tetratricopeptide repeat protein 0XPPY Cluster_583145 V1284124 S Endonuclease Exonuclease phosphatase 11EFS Cluster_699457 V1284126 S NA 0XXGZ Cluster_583146 V1284128 FSAB map00030,map01100,map01110,map01120,map01230 G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) COG0176 Cluster_583147 V1284130 DXS map00730,map00900,map01100,map01110 H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) COG1154 Cluster_805436 V1284132 PUNA map00230,map00240,map00760,map01100,map01110 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) COG1683 Cluster_692442 V1284133 PEPA map00480,map01100 E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) COG0260 Cluster_649261 V1284136 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_583148 V1284137 PDH map00330,map01100,map01110 E proline dehydrogenase COG0506 Cluster_583149 V1284138 AHPF O Alkyl hydroperoxide reductase COG3634 Cluster_670198 V1284139 S Bacterial membrane protein 0XT2P Cluster_583150 V1284140 PORAS_1052 L Transposase COG2801 Cluster_583152 V1284142 CDR P pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_583154 V1284144 CLCAR_1091 T Histidine kinase COG0642 Cluster_586267 V1284145 S X-X-X-Leu-X-X-Gly heptad repeats COG1511 Cluster_583155 V1284146 BGR_15850 L Inherit from COG: DNA primase 0XR3E Cluster_745009 V1284148 CYSK map00270,map00920,map01100,map01120,map01230 E cysteine synthase COG0031 Cluster_596414 V1284150 PADR K Transcriptional regulator COG1695 Cluster_583156 V1284151 P Voltage gated chloride channel COG0038 Cluster_696183 V1284152 S NA 0ZVJP Cluster_583157 V1284153 P TonB-dependent receptor Plug 0XNPQ Cluster_583158 V1284154 K Transcriptional regulator, TetR family 11S7S Cluster_586268 V1284159 NTPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_583161 V1284160 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_583162 V1284161 G Major Facilitator 0XP2I Cluster_586269 V1284162 NHAC C Na H antiporter COG1757 Cluster_583163 V1284163 map02010 P ABC 3 transport family COG1108 Cluster_603528 V1284164 PSTB2 map02010 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 Cluster_607139 V1284165 YIGZ map00240,map00670,map01100 S protein family UPF0029, Impact, N-terminal protein COG1739 Cluster_586270 V1284166 map02010 P ABC transporter COG1131 Cluster_653350 V1284171 RIMK map00300,map01100,map01210,map01230 J Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) COG0189 Cluster_649262 V1284172 RFBD map00521,map00523,map01100,map01110 M Dtdp-4-dehydrorhamnose reductase COG1091 Cluster_586271 V1284174 YLOV S dak2 domain fusion protein ylov COG1461 Cluster_621911 V1284175 FABD map00061,map01100 I malonyl CoA-acyl carrier protein transacylase COG0331 Cluster_721790 V1284178 M glycosyltransferase group 1 family protein COG0438 Cluster_583164 V1284179 map00500,map00511,map01100 N Alpha-L-fucosidase 0XPGV Cluster_583165 V1284181 MT1053 D Septum formation initiator family protein COG1507 Cluster_583166 V1284182 HEMY H HemY protein COG3071 Cluster_583167 V1284183 CYSE map00270,map00920,map01100,map01120,map01230 E serine acetyltransferase COG1045 Cluster_583168 V1284184 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_583169 V1284185 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_583170 V1284186 HYBC map00633,map01120 C Large subunit COG0374 Cluster_586273 V1284188 FTSW map04112 D cell cycle protein, FtsW RodA SpoVE family COG0772 Cluster_688021 V1284189 SUA J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0009 Cluster_589545 V1284191 S NA 100W0 Cluster_586275 V1284193 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_586276 V1284194 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_738304 V1284196 HK07 map02020 T Histidine kinase COG2972 Cluster_852104 V1284197 SBM map00280,map00630,map00640,map00720,map01100,map01120 I Methylmalonyl-coA mutase COG2185 Cluster_868183 V1284202 S NA 121RG Cluster_586278 V1284203 V ABC transporter COG1132 Cluster_583171 V1284204 S SAM-dependent methyltransferase COG1092 Cluster_699458 V1284207 HYDC map00190,map00910,map01100 C -hydrogenase COG4624 Cluster_702487 V1284210 S Uncharacterized conserved protein (DUF2304) 124N2 Cluster_586280 V1284212 FUCO map00620,map00630,map01120 C alcohol dehydrogenase COG1454 Cluster_586281 V1284213 G hydrolase family 43 0XQ21 Cluster_586282 V1284214 CDD map00240,map00983,map01100,map05219 F cytidine deaminase COG0295 Cluster_583172 V1284215 V ABC transporter COG1132 Cluster_583173 V1284216 SCRK map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G fructokinase COG1940 Cluster_583174 V1284219 YIDE P transport protein COG2985 Cluster_721791 V1284220 K Transcriptional regulator, ARAC family 125DJ Cluster_586284 V1284221 map03420,map03430 L helicase COG0210 Cluster_586285 V1284222 BA_1953 map00363,map00960,map01120 S alpha beta 11FW9 Cluster_696184 V1284223 FAT map00061,map01100 I Acyl-ACP thioesterase COG3884 Cluster_683591 V1284225 METG map00450,map00970 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 Cluster_586287 V1284226 GLUP G glucose galactose transporter COG0738 Cluster_586288 V1284228 MSMK map02010 G (ABC) transporter COG3839 Cluster_848301 V1284229 RPMG map03010 J 50S ribosomal protein L33 COG0267 Cluster_586289 V1284230 ENO map00010,map00680,map01100,map01110,map01120,map01230,map03018,map04066 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 Cluster_586292 V1284234 DCMB map00270,map01100 H C-5 cytosine-specific DNA methylase COG0270 Cluster_586293 V1284235 INSI L transposase COG2826 Cluster_821076 V1284237 map02010 V (ABC) transporter COG1131 Cluster_614513 V1284240 NUSA K Transcription elongation factor NusA COG0195 Cluster_586294 V1284241 PAGP map05133 M PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) 17419@proNOG Cluster_586295 V1284242 map02010 P ABC superfamily ATP binding cassette transporter ABC protein COG1122 Cluster_586296 V1284243 INTA L Integrase COG0582 Cluster_586297 V1284246 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_596415 V1284247 YYBT T domain protein COG3887 Cluster_586298 V1284249 RHUM S DNA-binding protein COG3943 Cluster_657467 V1284252 LACZ map00052,map00511,map00600,map01100 G Beta-galactosidase COG3250 Cluster_699459 V1284253 MENA map00130,map01100,map01110 H 1,4-dihydroxy-2-naphthoate octaprenyltransferase COG1575 Cluster_586300 V1284254 S smc domain-containing protein 0XTF4 Cluster_586301 V1284256 S NA 0XQBQ Cluster_586303 V1284258 S Membrane COG0628 Cluster_586304 V1284259 V Type I restriction enzyme R protein N terminus (HSDR_N) COG0610 Cluster_586305 V1284260 PEPN map00480,map01100 E Aminopeptidase COG0308 Cluster_586306 V1284261 M polysaccharide deacetylase COG0726 Cluster_715230 V1284262 ENGB S Necessary for normal cell division and for the maintenance of normal septation (By similarity) COG0218 Cluster_586307 V1284264 S NA 11P3R Cluster_586308 V1284266 YOJN S ATPase associated with various cellular activities aaa_5 COG0714 Cluster_586309 V1284267 ACRB V MMPL family COG0841 Cluster_645157 V1284268 map00230,map01100,map01110 F phosphoribosylformylglycinamidine synthase COG0047 Cluster_586310 V1284269 map04974 E Dipeptidyl peptidase IV (DPP IV) N-terminal region COG1506 Cluster_586311 V1284270 GLYQS map00970 J Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) COG0423 Cluster_705591 V1284272 S NA 121S9 Cluster_905253 V1284273 DET0272 L Phage integrase COG0582 Cluster_766533 V1284274 HSDS1 V type I restriction-modification system COG0732 Cluster_741704 V1284276 RELE S cytotoxic translational repressor 0XYWD Cluster_825044 V1284279 S NA 0ZHU9 Cluster_725141 V1284281 S Protein of unknown function (DUF3575) 0YB26 Cluster_586314 V1284282 YHHK S -acetyltransferase 17G1D@proNOG Cluster_586315 V1284283 APPY map02020 K Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions COG2207 Cluster_913579 V1284284 YJIM E 2-hydroxyglutaryl-CoA dehydratase COG1775 Cluster_896626 V1284285 S NA 0XR9X Cluster_711862 V1284287 YBBC V conserved protein UCP016719 COG3876 Cluster_670199 V1284288 U type ii secretion system 11NQ9 Cluster_586316 V1284289 ARGK E lAO AO transport system ATPase COG1703 Cluster_586317 V1284290 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_929197 V1284292 RPLQ map03010 J 50S ribosomal protein l17 COG0203 Cluster_731735 V1284293 RPOA map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 Cluster_586318 V1284294 L NA 0YZ4U Cluster_586319 V1284296 AGAD map00051,map00052,map00520,map01100,map02060 G PTS System COG3716 Cluster_586320 V1284297 MSBA map02010 V ABC transporter transmembrane region COG1132 Cluster_589546 V1284298 S NA 0ZMUF Cluster_688022 V1284299 S NA 11F81 Cluster_589547 V1284300 DPPB map02010 E, P transporter, permease COG0601 Cluster_721792 V1284301 L Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) COG0816 Cluster_876306 V1284303 RPLI map03010 J Binds to the 23S rRNA (By similarity) COG0359 Cluster_679022 V1284304 HEMG map00860,map01100,map01110 H Flavin containing amine oxidoreductase COG1232 Cluster_586321 V1284305 map00010,map01110,map01120 G aldose 1-epimerase COG2017 Cluster_586322 V1284306 U, W Pfam:YadA COG5295 Cluster_586323 V1284307 PLCR K HTH_XRE 0XUC3 Cluster_603529 V1284308 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_766534 V1284309 PORC map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120 C oxidoreductase gamma subunit COG1014 Cluster_679023 V1284310 YFDR S Metal Dependent Phosphohydrolase COG1896 Cluster_872187 V1284312 GLYA map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01230 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) COG0112 Cluster_777632 V1284313 YWLG S UPF0340 protein COG4475 Cluster_589548 V1284314 COMEA L Competence protein COG1555 Cluster_665877 V1284315 S NA 0XNWW Cluster_715231 V1284317 S NA 11GMQ Cluster_599914 V1284318 G ABC transporter integral membrane protein COG1172 Cluster_586324 V1284319 P permease COG0628 Cluster_657468 V1284321 YXJI S Pfam:DUF567 COG4894 Cluster_589549 V1284323 YISR map02020 K Transcriptional regulator, ARAC family 11AZ4 Cluster_586327 V1284326 S radical SAM domain protein 11I15 Cluster_817181 V1284327 GLMS map00250,map00520,map01100,map01110 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 Cluster_586328 V1284329 MGTE P magnesium transporter COG2239 Cluster_589550 V1284330 CLPC O ATP-dependent CLP protease ATP-binding subunit COG0542 Cluster_586329 V1284331 PEPF E Oligoendopeptidase f COG1164 Cluster_586331 V1284336 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_781453 V1284337 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_789528 V1284338 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_589551 V1284340 T Histidine kinase COG0642 Cluster_589552 V1284341 C radical SAM domain protein COG1032 Cluster_586333 V1284342 LDTA S ErfK YbiS YcfS YnhG COG1376 Cluster_589553 V1284343 RSMA J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 Cluster_766535 V1284345 S NA 0YR87 Cluster_589555 V1284347 NHAA map00680 P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) COG3004 Cluster_586334 V1284350 APPF map02010 E Oligopeptide dipeptide abc transporter, atpase subunit COG4608 Cluster_586335 V1284351 M peptidase COG0739 Cluster_586336 V1284352 P tonB-dependent Receptor 0XRJW Cluster_674579 V1284354 INFB J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 Cluster_696185 V1284355 HEML map00860,map01100,map01110 H Glutamate-1-semialdehyde aminotransferase COG0001 Cluster_586337 V1284356 SURB S G5 domain protein 0ZVV3 Cluster_586338 V1284358 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_586339 V1284359 RPOS map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_589558 V1284361 S Abc transporter COG0488 Cluster_692443 V1284362 NPLT map00052,map00500,map01100,map04973 G alpha amylase, catalytic region COG0366 Cluster_589559 V1284363 LGAS_0605 S phage terminase large subunit 0XSCY Cluster_586340 V1284364 TYPA T gtp-binding protein typa COG1217 Cluster_781454 V1284365 YQGV S Domain of unknown function DUF77 COG0011 Cluster_589560 V1284367 PGI map00010,map00030,map00500,map00520,map01100,map01110,map01120 G phosphohexose isomerase COG0166 Cluster_702488 V1284368 CAT map00281,map00620,map00626,map01110,map01120 C Transferase COG0427 Cluster_586341 V1284370 SCRK map00010,map00051,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G fructokinase COG1940 Cluster_586342 V1284371 CARA map00240,map00250,map01100 F carbamoyl-phosphate synthetase glutamine chain COG0505 Cluster_770242 V1284372 S NA 0ZWE1 Cluster_589561 V1284373 TRAA map03440 L mobA MobL family protein COG0507 Cluster_586343 V1284374 HLYIII S hemolysin iii COG1272 Cluster_589562 V1284375 C Flavodoxin COG0716 Cluster_589563 V1284376 V Type III restriction enzyme, res subunit 0Y2F5 Cluster_589564 V1284377 PNP map00230,map00240,map03018 J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) COG1185 Cluster_586344 V1284378 OTSB map00500,map01100 G K01087 trehalose 6-phosphate phosphatase EC 3.1.3.12 COG1877 Cluster_589565 V1284379 YITL S S1 RNA binding domain protein COG2996 Cluster_621912 V1284380 CYSC map00230,map00920,map01100,map01120 P Catalyzes the synthesis of activated sulfate (By similarity) COG0529 Cluster_589566 V1284384 S NA 0XQ58 Cluster_892490 V1284385 map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E ACT domain protein COG0527 Cluster_589567 V1284387 J acetyltransferase, (GNAT) family COG1670 Cluster_645158 V1284388 COBD map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01230 E decarboxylase COG0079 Cluster_589568 V1284391 M Membrane bOund o-acyl transferase mboat family protein COG1696 Cluster_589569 V1284392 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_589570 V1284396 RELA map00230 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 Cluster_589571 V1284397 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_711864 V1284399 S Abortive infection protein AbiGI 11WH3 Cluster_589573 V1284400 NHAC-1 map00680 C Na H antiporter COG1757 Cluster_848303 V1284401 UDP map00240,map00983,map01100 F Uridine phosphorylase COG2820 Cluster_589574 V1284402 APEB E M18 family aminopeptidase COG1362 Cluster_770243 V1284404 PPDK map00620,map00680,map00710,map00720,map01100,map01120 G pyruvate phosphate dikinase COG0574 Cluster_589575 V1284405 CSD1 L CRISPR-associated protein Csd1 family 0ZVNC Cluster_589576 V1284406 HEMC map00860,map01100,map01110 H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) COG0181 Cluster_589577 V1284408 M NA 11FBZ Cluster_589578 V1284409 RECG map03440 L ATP-dependent DNA helicase recG COG1200 Cluster_614515 V1284410 UVRD map03420,map03430 L ATP-dependent DNA helicase pcra COG0210 Cluster_641274 V1284411 MURI map00230,map00240,map00471,map01100 M Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) COG0796 Cluster_589579 V1284412 NFED O nodulation efficiency protein D COG1030 Cluster_589580 V1284415 H MMPL domain protein COG2409 Cluster_708665 V1284417 SERC map00260,map00680,map00750,map01100,map01120,map01230 E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) COG1932 Cluster_589581 V1284418 S AIG2-like family COG2105 Cluster_589582 V1284419 PHSA map00450 C Thiosulfate reductase COG0243 Cluster_589583 V1284420 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_589584 V1284421 EPSV map00051 M glycosyltransferase group 2 family protein COG0463 Cluster_589585 V1284422 S NA 0XUFD Cluster_657469 V1284424 S Inherit from COG: ATPase (AAA COG1373 Cluster_589586 V1284425 RECQ map03018 L ATP-dependent DNA helicase RecQ COG0514 Cluster_589587 V1284426 YLBM S UPF0348 protein COG1323 Cluster_589588 V1284427 HTPG map04141,map04151,map04612,map04621,map04626,map04914,map04915,map05200,map05215 O Molecular chaperone. Has ATPase activity (By similarity) COG0326 Cluster_840383 V1284428 FTSK D cell division protein FtsK COG1674 Cluster_805438 V1284429 PGSA map00564,map01100 I cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase COG0558 Cluster_670200 V1284430 S had-superfamily hydrolase, subfamily iib COG0561 Cluster_589589 V1284431 SP_0885 S domain protein 0XRFP Cluster_589590 V1284433 TIG O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COG0544 Cluster_715232 V1284434 PITA P phosphate transporter COG0306 Cluster_852106 V1284435 S NA 0ZHU9 Cluster_589591 V1284437 ADDA L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation COG1074 Cluster_589592 V1284439 K transcriptional regulator DeoR family COG1349 Cluster_589593 V1284441 S NA 0YH2T Cluster_589594 V1284443 BMUL_2188 S Uroporphyrin-iii c tetrapyrrole (Corrin porphyrin) methyltransferase COG0313 Cluster_589595 V1284444 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_718488 V1284446 L Inherit from COG: Integrase COG0582 Cluster_603530 V1284447 YHFE E m42 family COG1363 Cluster_589597 V1284448 TIG O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COG0544 Cluster_592942 V1284449 M (LipO)protein COG2853 Cluster_592943 V1284450 BMPD S basic membrane COG1744 Cluster_657470 V1284451 THID map00730,map01100 H phosphomethylpyrimidine kinase COG0351 Cluster_589598 V1284452 S (LipO)protein 11J26 Cluster_618269 V1284453 S Hydrolase COG0561 Cluster_797289 V1284456 UPPP map00550 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) COG1968 Cluster_836445 V1284458 MANB map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G phosphomannomutase COG1109 Cluster_809451 V1284459 YERC S protein, YerC YecD COG4496 Cluster_589599 V1284460 AROK map00400,map01100,map01110,map01230 E Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) COG0703 Cluster_708666 V1284461 YQXD S UPF0178 protein COG1671 Cluster_641275 V1284462 SUFC O feS assembly ATPase SufC COG0396 Cluster_589600 V1284463 T ATPase histidine kinase DNA gyrase B HSP90 domain protein 0ZIAQ Cluster_844420 V1284464 K RNA Polymerase 11UY6 Cluster_589601 V1284467 RECQ2 map03018 L ATP-dependent DNA helicase RecQ COG0514 Cluster_589602 V1284468 COMM O Mg chelatase subunit ChlI COG0606 Cluster_592944 V1284469 ASRB C sulfite reductase subunit b COG0543 Cluster_738305 V1284470 MANA map00051,map00520,map01100,map01110 G mannose-6-phosphate isomerase COG1482 Cluster_913580 V1284471 NAGH map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 S K01197 hyaluronoglucosaminidase EC 3.2.1.35 0XPBQ Cluster_633227 V1284472 L recombinase (Phage integrase family) COG0582 Cluster_589603 V1284473 V Inherit from firmNOG: Restriction modification system DNA specificity COG0732 Cluster_589604 V1284474 YXCA I coA-substrate-specific enzyme activase COG3581 Cluster_633228 V1284475 S Phage tail tape measure protein, TP901 family COG5283 Cluster_589605 V1284476 PSUG map00240 Q Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) COG2313 Cluster_696186 V1284477 BMUL_2113 S Pfam:DUF88 COG1432 Cluster_589606 V1284478 LDTA S ErfK YbiS YcfS YnhG COG1376 Cluster_589607 V1284479 LYSM S Lysm domain protein 12BED Cluster_589608 V1284480 ASNA map00250,map00460,map00910,map01100,map01110,map01230 E asparagine synthetase A COG2502 Cluster_599915 V1284482 YIHY S ribonuclease BN COG1295 Cluster_589609 V1284483 S Replication initiator protein 0XR3Z Cluster_589610 V1284484 PUCB map00230,map01100,map01120 O 4-diphosphocytidyl-2c-methyl-d-erythritol synthase COG2068 Cluster_821078 V1284485 RNHA map03030 S ribonuclease COG3341 Cluster_832626 V1284486 AMYA map00500,map01100,map04973 G Alpha-amylase COG0366 Cluster_592945 V1284487 ISPH map00900,map01100,map01110,map03010 I Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) COG0761 Cluster_629407 V1284490 S glycosyltransferase 0Y8FN Cluster_777633 V1284492 C, Q Microcompartments protein COG4577 Cluster_741705 V1284493 ARGH map00250,map00330,map01100,map01110,map01230 E arginosuccinase COG0165 Cluster_614516 V1284494 S Membrane COG5006 Cluster_610782 V1284496 HRCA K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) COG1420 Cluster_589612 V1284497 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_592946 V1284498 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_589613 V1284499 YBIW map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_674580 V1284500 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_589614 V1284501 S Pfam:DUF88 0Y5TM Cluster_592947 V1284504 GLPQ map00564 C glycerophosphoryl diester phosphodiesterase COG0584 Cluster_728460 V1284505 K Transcriptional regulatory protein, C-terminal domain protein COG0745 Cluster_592948 V1284507 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_618270 V1284510 S UPF0272 protein COG1641 Cluster_592949 V1284511 K Transcriptional regulator COG1414 Cluster_589616 V1284512 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E brancheD-chain amino acid aminotransferase COG0115 Cluster_592950 V1284513 SSTT E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) COG3633 Cluster_592951 V1284514 ETFA map00910 C Electron transfer flavoprotein COG2025 Cluster_592952 V1284516 FADD15 map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG1022 Cluster_592953 V1284517 SP_0899 S Membrane Associated 114SZ Cluster_589618 V1284519 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_592954 V1284520 RPSD map03010 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) COG0522 Cluster_592955 V1284522 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_592956 V1284525 AGCS E amino acid carrier protein COG1115 Cluster_589619 V1284526 MNMA map04122 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 Cluster_777634 V1284529 S NA 17UYD@proNOG Cluster_589620 V1284530 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_589621 V1284531 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_592957 V1284533 GLUQ map00860,map00970,map01100,map01110 J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) COG0008 Cluster_718489 V1284534 GLGB map00500,map01100,map01110 G 1,4-alpha-glucan branching enzyme COG0296 Cluster_592958 V1284535 ARGG map00250,map00330,map01100,map01110,map01230 E Citrulline--aspartate ligase COG0137 Cluster_661673 V1284537 HEMA map00860,map01100,map01110 H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) COG0373 Cluster_728461 V1284538 FUSA2 T elongation factor G COG0480 Cluster_665878 V1284540 SP_2057 I Acyl-transferase COG1835 Cluster_592960 V1284541 T PAS domain S-box protein 0XNMH Cluster_592962 V1284545 C Hydrogenase large subunit domain protein COG4624 Cluster_592963 V1284547 DAPA map00300,map01100,map01110,map01120,map01230 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) COG0329 Cluster_589622 V1284548 RIML map00350,map00362,map00627,map00642,map00903,map01120 J acetyltransferase COG1670 Cluster_745013 V1284550 YFJY L dna repair protein COG2003 Cluster_641276 V1284553 map03420,map03430 L helicase COG0210 Cluster_589625 V1284555 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii COG0587 Cluster_592964 V1284557 S domain protein 0XS27 Cluster_592966 V1284559 UGTP map00561,map01100 M Monogalactosyldiacylglycerol synthase COG0707 Cluster_731736 V1284560 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_592967 V1284563 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_592969 V1284568 V abc transporter atp-binding protein COG1131 Cluster_633229 V1284569 T PAS domain S-box protein 0XNMH Cluster_592970 V1284570 VIRE L Virulence-associated protein e COG5545 Cluster_745014 V1284572 S NA 0ZHU9 Cluster_592971 V1284576 V Mate efflux family protein COG0534 Cluster_592973 V1284578 S repeat protein 11IAG Cluster_592974 V1284579 S Sss sodium solute transporter superfamily COG4146 Cluster_705592 V1284580 K Transcriptional regulator COG2508 Cluster_884466 V1284581 L Transposase 11M0T Cluster_592975 V1284585 S Ragb susd domain-containing protein 0ZKW2 Cluster_592977 V1284587 map02010 V ABC transporter COG1132 Cluster_592978 V1284588 MALQ map00500,map01100,map01110 G 4-alpha-glucanotransferase COG1640 Cluster_592979 V1284589 HISS map00970 J histidyl-tRNA synthetase COG0124 Cluster_592980 V1284590 L type iii restriction protein res subunit COG1061 Cluster_592981 V1284592 DCM map00270,map01100 L C-5 cytosine-specific DNA methylase COG0270 Cluster_641277 V1284593 SCLAV_3115 O DSBA oxidoreductase COG1651 Cluster_781456 V1284594 LUXS map00270,map05111 T Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) COG1854 Cluster_592982 V1284595 S Arylsulfotransferase (ASST) 0XPAA Cluster_696188 V1284597 PAAH map00360,map00362,map00650,map01100,map01120 I 3-hydroxyacyl-coa dehydrogenase COG1250 Cluster_844422 V1284598 MEND map00130,map01100,map01110 H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) COG1165 Cluster_629408 V1284599 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_888379 V1284600 SUFB O FeS assembly protein SUFB COG0719 Cluster_762585 V1284601 O sufB sufD domain protein COG0719 Cluster_592983 V1284602 S NA 0YYF9 Cluster_821080 V1284604 T Y_Y_Y domain COG5002 Cluster_592984 V1284605 TRKA P TrkA-N domain protein COG0569 Cluster_618271 V1284606 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_592985 V1284608 NHAA map00680 P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) COG3004 Cluster_592986 V1284609 NADE map00760,map01100 H Nad synthetase COG0388 Cluster_592987 V1284610 SP_0341 S UPF0371 protein COG4868 Cluster_592988 V1284611 RADA O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 Cluster_817184 V1284612 T Regulator COG0745 Cluster_653352 V1284613 PNTB map00760,map01100 C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) COG1282 Cluster_592989 V1284614 MVIN map00550 T Integral membrane protein (MviN COG0728 Cluster_592990 V1284615 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_592992 V1284618 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_645160 V1284619 RIBE map00740,map01100 H riboflavin synthase, subunit alpha COG0307 Cluster_715233 V1284620 V Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) COG1136 Cluster_592993 V1284621 V N-6 DNA Methylase COG0286 Cluster_592994 V1284622 COABC map00770,map01100 H Phosphopantothenoylcysteine decarboxylase COG0452 Cluster_592995 V1284623 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_592997 V1284625 PURK map00230,map01100,map01110 F phosphoribosylaminoimidazole carboxylase atpase subunit COG0026 Cluster_596416 V1284626 GCDB map00330,map00362,map00620,map00650,map01100,map01120 C decarboxylase (Beta subunit) COG1883 Cluster_596418 V1284631 RFBA map00521,map00523,map01100,map01110 M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) COG1209 Cluster_592998 V1284632 IADA S Isoaspartyl dipeptidase 16SV6@proNOG Cluster_592999 V1284634 map00260,map01100 C pyridine nucleotide-disulfide oxidoreductase COG0446 Cluster_593000 V1284635 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_593001 V1284636 S Inherit from NOG: domain protein 0XQ9I Cluster_593002 V1284637 U TraG family COG3505 Cluster_805440 V1284638 S NA 185Z8@proNOG Cluster_649263 V1284641 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III (Alpha subunit) COG0587 Cluster_593003 V1284642 YKGD K transcriptional regulator COG2207 Cluster_593004 V1284643 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_593005 V1284644 S NA 0ZQEH Cluster_593006 V1284645 SP_1232 S Membrane COG4684 Cluster_593007 V1284646 HGDB E dehydratase COG1775 Cluster_596420 V1284647 METK map00270,map01100,map01110 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 Cluster_832627 V1284648 METI map02010 P ABC transporter, permease COG2011 Cluster_637287 V1284649 J RNA methyltransferase COG2265 Cluster_641278 V1284651 GLTA map00250,map00910,map01100,map01110,map01120,map01230 E Glutamate synthase COG0543 Cluster_751790 V1284652 MODE H TOBE domain protein COG3585 Cluster_817185 V1284656 M Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) COG1807 Cluster_596421 V1284658 DNAN map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 Cluster_755262 V1284661 S domain protein 11MCV Cluster_721793 V1284664 GARR map00630,map01100 I NAD binding domain of 6-phosphogluconate dehydrogenase COG2084 Cluster_781457 V1284665 NDK map00230,map00240,map01100,map01110 F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) COG0105 Cluster_805441 V1284666 PEPI map00330 E Releases the N-terminal proline from various substrates (By similarity) COG0596 Cluster_785528 V1284667 YBJE S Membrane COG2431 Cluster_859943 V1284668 S Membrane protein of unknown function (DUF340) 1247A Cluster_593009 V1284669 T Histidine kinase COG0642 Cluster_864239 V1284672 MVAS map00072,map00280,map00650,map00900,map01100,map01110 I Hydroxymethylglutaryl-CoA synthase COG3425 Cluster_785529 V1284673 MVAA map00900,map01100,map01110,map04976 I hydroxymethylglutaryL-CoA reductase COG1257 Cluster_596422 V1284675 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_821082 V1284678 S NA 0YTRI Cluster_674583 V1284680 YLOV S dak2 domain fusion protein ylov COG1461 Cluster_593012 V1284681 PARE L Dna topoisomerase iv (Subunit b) COG0187 Cluster_770245 V1284682 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_721794 V1284683 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_610783 V1284684 LHR L helicase COG1201 Cluster_641279 V1284685 S Inherit from COG: Metal Dependent Phosphohydrolase COG2316 Cluster_596423 V1284686 S atpase, aaa COG1373 Cluster_593013 V1284688 S Immunoreactive 84 kDa antigen 0Y0NA Cluster_797290 V1284690 TRKA P potassium transporter peripheral membrane COG0569 Cluster_683592 V1284691 map00300,map01100,map01110,map01120,map01230 S dihydrodipicolinate reductase COG3804 Cluster_725142 V1284692 M peptidase COG0739 Cluster_596424 V1284693 AMYA map00500,map01100,map04973 G Alpha-amylase COG0366 Cluster_596425 V1284694 NIFJ map00720,map00910,map01120 C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) COG1014 Cluster_762586 V1284696 SRTD M Sortase family COG3764 Cluster_596426 V1284697 S Rib/alpha-like repeat 0YK85 Cluster_593014 V1284698 YPDC S Conserved Protein COG3538 Cluster_596427 V1284701 HPRA map00260,map00630,map00680,map01100,map01110,map01120 C D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain COG1052 Cluster_596428 V1284704 PRIA map03440 L Primosomal protein n' COG1198 Cluster_593016 V1284705 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_762587 V1284706 RPH map00230,map00240,map01100 J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) COG0689 Cluster_596429 V1284708 ARCC map00230,map00330,map00910,map01120 E carbamate kinase COG0549 Cluster_728462 V1284709 S Protein of unknown function (DUF3108) 11Z9Q Cluster_758771 V1284710 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_596430 V1284712 S NA 0Y5ZK Cluster_593017 V1284713 YGEW E Carbamoyltransferase COG0078 Cluster_603531 V1284714 S NA 0XVZR Cluster_593018 V1284716 L Inherit from COG: transposase COG3666 Cluster_670201 V1284717 S tetratricopeptide 11P8K Cluster_596432 V1284718 S NA 11NI8 Cluster_596433 V1284719 CYDD map02010 V ABC, transporter COG4988 Cluster_629409 V1284722 GLSA map00250,map00330,map00471,map00910,map01100,map01120,map04724,map04727,map04964 E Glutaminase COG2066 Cluster_696189 V1284723 S NA 0XQBQ Cluster_665879 V1284724 DPPD E, P ABC transporter COG0444 Cluster_593019 V1284725 S NA 0YNFS Cluster_766537 V1284726 S metal-binding protein COG4887 Cluster_596434 V1284727 E Aldehyde dehydrogenase family COG0014 Cluster_758772 V1284728 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_596435 V1284729 GLGB map00500,map01100,map01110 G 1,4-alpha-glucan branching enzyme COG0296 Cluster_596436 V1284730 FRR J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 Cluster_596437 V1284731 D Chromosome Partitioning Protein COG1192 Cluster_596439 V1284735 ARNF G Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) COG0697 Cluster_596440 V1284736 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E brancheD-chain amino acid aminotransferase COG0115 Cluster_596441 V1284737 PYCA map00020,map00061,map00253,map00620,map00640,map00720,map01100,map01110,map01120,map01230 I acetyl-CoA carboxylase biotin carboxylase COG0439 Cluster_596442 V1284738 YIAU K Transcriptional regulator 17614@proNOG Cluster_596443 V1284739 YHEH V Abc transporter COG1132 Cluster_596444 V1284740 SP_0859 S Membrane COG3817 Cluster_848308 V1284741 map02010 P (ABC) transporter 11J3T Cluster_821084 V1284742 map02010 P abc transporter COG1131 Cluster_657471 V1284743 HYDA map00240,map00410,map00770,map00983,map01100 F dihydropyrimidinase (EC 3.5.2.2) COG0044 Cluster_844425 V1284745 S sigma-70, region 4 11JJM Cluster_596445 V1284746 H amine oxidase COG1232 Cluster_596446 V1284747 S hydrolase, CocE NonD family protein COG2936 Cluster_661674 V1284749 S Membrane COG1811 Cluster_614517 V1284750 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G Phosphohexokinase COG0205 Cluster_596448 V1284751 M Inherit from NOG: Gram positive anchor 11HQ6 Cluster_596449 V1284752 TAL map00030,map01100,map01110,map01120,map01230 G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) COG0176 Cluster_670202 V1284756 PPAC map00190 C Manganese-dependent inorganic pyrophosphatase COG1227 Cluster_731737 V1284759 LRGA map02020 S lrga family COG1380 Cluster_731738 V1284760 L Inherit from COG: Integrase COG0582 Cluster_596453 V1284762 PLPD S Phospholipase, patatin family COG1752 Cluster_596454 V1284763 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_705594 V1284765 S NA 0YB2E Cluster_596455 V1284766 GCDB map00330,map00362,map00620,map00650,map01100,map01120 C decarboxylase (Beta subunit) COG1883 Cluster_596456 V1284767 PILT N, U twitching motility protein COG2805 Cluster_596457 V1284768 K Transcriptional Regulator AraC Family COG2207 Cluster_621914 V1284769 T FecR protein COG3712 Cluster_596458 V1284770 PROS map00970 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) COG0442 Cluster_596459 V1284771 DUSB J Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_734976 V1284772 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_702489 V1284774 DXS map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase COG3958 Cluster_641280 V1284777 USHA F 5-nucleotidase COG0737 Cluster_596460 V1284779 map00270,map01100,map04122 P sulfurtransferase COG2897 Cluster_596461 V1284781 ASPB K Transcriptional regulator COG1167 Cluster_596463 V1284783 FBPA K Fibronectin-binding protein COG1293 Cluster_596464 V1284784 PURU map00630,map00670 F formyltetrahydrofolate deformylase COG0788 Cluster_848309 V1284785 TUSA map04122 P Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) COG0425 Cluster_596465 V1284786 G alpha amylase, catalytic COG0366 Cluster_596466 V1284788 MNMG D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 Cluster_777636 V1284789 PRIA map03440 L Primosomal protein n' COG1198 Cluster_596468 V1284793 HSDS V restriction COG0732 Cluster_770246 V1284794 S Protein of unknown function (DUF3343) 0ZXTN Cluster_596469 V1284796 G ABC, transporter COG1175 Cluster_596470 V1284797 RACS map02020 T Histidine kinase COG0642 Cluster_599917 V1284800 M polysaccharide biosynthesis protein 0XNV1 Cluster_596472 V1284801 K Transcriptional regulator, ARAC family COG2207 Cluster_599918 V1284803 MENF map00130,map01053,map01100,map01110 H Isochorismate synthase COG1169 Cluster_599919 V1284804 S NA 124TN Cluster_599920 V1284806 UVRA map03420 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 Cluster_734977 V1284808 YHBY J Rna-binding protein COG1534 Cluster_621915 V1284809 RC1_2786 L transposase COG5433 Cluster_599921 V1284810 PHBA map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map02020 I acetyl-CoA COG0183 Cluster_770247 V1284813 S NA 0XPKA Cluster_762588 V1284815 DGOD map00052 G Galactonate dehydratase COG4948 Cluster_596475 V1284816 NUOH map00190,map00910,map01100 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) COG1005 Cluster_649264 V1284817 COBK map00860,map01100 H reductase COG2099 Cluster_596476 V1284818 AGUA map00330,map01100 E Agmatine deiminase COG2957 Cluster_696190 V1284819 SRTB U sortase, SrtB family COG4509 Cluster_637289 V1284820 SBCC L Exonuclease COG0419 Cluster_596477 V1284821 RPOD map05111 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 Cluster_596478 V1284822 S domain protein 0ZKXH Cluster_770248 V1284827 S Nitroreductase 11QVA Cluster_596479 V1284829 S NA 10NBR Cluster_603532 V1284830 YRFF S intracellular growth attenuator 16Q1I@proNOG Cluster_599922 V1284831 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_599923 V1284832 AGAS map00250,map00520,map01100,map01110 M isomerase COG2222 Cluster_596480 V1284833 E ferredoxin-dependent glutamate synthase COG0069 Cluster_657472 V1284834 LMRA map02010 V abc transporter COG1132 Cluster_596481 V1284835 SELB map00450,map00970 J Selenocysteine-specific translation elongation factor COG3276 Cluster_596482 V1284836 PITRM1 O peptidase COG1026 Cluster_596483 V1284837 M efflux transporter, outer membrane factor lipoprotein, NodT family COG1538 Cluster_596485 V1284839 PARB K parb-like partition protein COG1475 Cluster_596486 V1284840 RBSA map02010 P ATP-binding protein COG1129 Cluster_596487 V1284841 K Inherit from firmNOG: Transcriptional regulator COG2865 Cluster_748356 V1284842 S NA 0Y9CE Cluster_599924 V1284844 NNRD G Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) COG0063 Cluster_599925 V1284846 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_599926 V1284849 S NA 0XPGY Cluster_596488 V1284850 S ErfK YbiS YcfS YnhG COG1376 Cluster_596489 V1284854 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_649265 V1284855 YAAK S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) COG0718 Cluster_596490 V1284856 AMIC map02010 P abc transporter, permease COG0601 Cluster_596491 V1284857 M YD repeat protein COG3209 Cluster_773933 V1284858 K Transcriptional regulator (XRE family COG1396 Cluster_777637 V1284860 S NA 11NHY Cluster_872191 V1284861 S NA 11GEU Cluster_599927 V1284862 YCAN K LysR family Transcriptional regulator 16TEJ@proNOG Cluster_665880 V1284863 S NA 0XQ5J Cluster_599928 V1284865 METH map00270,map00450,map00670,map01100,map01110,map01230 E Methionine synthase COG1410 Cluster_711865 V1284867 M efflux transporter, outer membrane factor lipoprotein, NodT family COG1538 Cluster_657473 V1284868 TRML map04122 J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) COG0219 Cluster_596493 V1284871 map00627,map00740,map01120,map05152 S Phosphatase COG1409 Cluster_797291 V1284872 YIGA S Protein of unknown function, DUF484 COG3159 Cluster_596494 V1284873 FNI map00900,map01100,map01110 C Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) COG1304 Cluster_596495 V1284875 LDH map00010,map00270,map00620,map00640,map01100,map01110,map01120 C L-lactate dehydrogenase COG0039 Cluster_596496 V1284876 PEPD map00480,map01100 E aminoacyl-histidine dipeptidase COG2195 Cluster_755263 V1284878 S ThiW protein COG4732 Cluster_734978 V1284880 RFBB map00521,map00523,map01055,map01100,map01110 M DTDP-glucose 4,6-dehydratase COG1088 Cluster_674584 V1284883 S metallophosphoesterase 102A3 Cluster_599932 V1284884 PELA G pectate lyase 0ZZUN Cluster_596497 V1284885 CLS map00564,map01100 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 Cluster_599933 V1284886 S Inherit from NOG: antigen PG97 COG4886 Cluster_884468 V1284887 S phage plasmid primase, p4 family COG3378 Cluster_848310 V1284888 S phage plasmid primase, p4 family COG3378 Cluster_670203 V1284889 TRXB map00240,map00450 O Thioredoxin reductase COG0492 Cluster_848311 V1284890 S NA 0YV6J Cluster_599934 V1284891 PTSP map00051,map01100,map02060 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) COG1080 Cluster_657474 V1284892 APPB P Binding-protein-dependent transport systems, inner membrane component COG0601 Cluster_599938 V1284897 NORV map05132 C uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center COG0426 Cluster_813458 V1284900 YCIZ S UPF0509 protein 17MFC@proNOG Cluster_599939 V1284902 S Ser Thr phosphatase family protein COG1408 Cluster_599940 V1284903 TNPA L transposase COG4644 Cluster_599941 V1284905 G extracellular solute-binding protein family 1 0ZS3T Cluster_596498 V1284906 S ragb susd domaiN-containing protein 0Z7X3 Cluster_596499 V1284907 MRP D ATP-binding protein COG0489 Cluster_892494 V1284908 YWLG S UPF0340 protein COG4475 Cluster_880339 V1284909 HK09 map02020 T Histidine kinase COG2972 Cluster_596500 V1284910 S Membrane 11KXQ Cluster_599943 V1284913 RECQ map03018 L ATP-dependent DNA helicase RecQ COG0514 Cluster_599944 V1284914 M NAD dependent epimerase dehydratase family protein COG0451 Cluster_599945 V1284915 P tonB-dependent receptor plug 0YT3X Cluster_599946 V1284916 YXBA S ATP-grasp COG3919 Cluster_758774 V1284917 LSPA map03060 U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) COG0597 Cluster_688023 V1284918 AMIC map02010 P abc transporter, permease COG0601 Cluster_708667 V1284919 Y0392 S TIM-barrel signal transduction protein COG5564 Cluster_599947 V1284920 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_817188 V1284922 S NA 100NK Cluster_599950 V1284925 MUTS map03430 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 Cluster_599951 V1284926 RADC L DNA repair protein (RadC COG2003 Cluster_599952 V1284927 ASNA map00250,map00460,map00910,map01100,map01110,map01230 E asparagine synthetase A COG2502 Cluster_599953 V1284928 E Glycosyl Hydrolase Family 88 COG4225 Cluster_699461 V1284929 S Membrane COG2510 Cluster_599954 V1284930 V ABC transporter transmembrane region COG1132 Cluster_599955 V1284931 M TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_599956 V1284933 RUVC map03440 L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) COG0817 Cluster_599957 V1284934 HISC map00340,map00350,map00360,map00400,map00401,map00860,map00960,map01100,map01110,map01230 E imidazole acetol-phosphate transaminase COG0079 Cluster_599958 V1284935 S NA 0ZHVH Cluster_599959 V1284936 S permease COG2252 Cluster_599960 V1284937 BMPD S basic membrane COG1744 Cluster_599961 V1284938 MNME S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 Cluster_599963 V1284942 G Major Facilitator superfamily 0XPRB Cluster_637290 V1284943 METH map00270,map00450,map00670,map01100,map01110,map01230 E Methionine synthase COG1410 Cluster_599964 V1284944 S NA 0YWK8 Cluster_599965 V1284945 PROA map00330,map01100,map01230 E Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) COG0014 Cluster_637291 V1284946 OPPCD E, P abc transporter COG1173 Cluster_599966 V1284947 M 2 glycosyl transferase COG0463 Cluster_599967 V1284948 S P-loop domain protein 0XQDB Cluster_751791 V1284949 S NA 11JHT Cluster_641281 V1284953 COABC map00770,map01100 H Phosphopantothenoylcysteine decarboxylase COG0452 Cluster_762589 V1284954 map02010 S YodA lipocalin-like domain 11KBP Cluster_599969 V1284955 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_599970 V1284956 MICAU_0290 L Pfam:Transposase_8 COG2963 Cluster_679025 V1284957 S Ser Thr phosphatase family protein 11JEF Cluster_599973 V1284960 PYRC map00240,map01100 F dihydroorotase COG0044 Cluster_599975 V1284963 RSME S Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) COG1385 Cluster_599976 V1284964 PURM map00230,map01100,map01110 F Phosphoribosylformylglycinamidine cyclo-ligase COG0150 Cluster_599977 V1284965 S NA 10WDH Cluster_599978 V1284966 NAGZ map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 G Beta-N-acetyl-hexosaminidase COG3525 Cluster_762590 V1284967 NUPC F nucleoside COG1972 Cluster_599979 V1284968 P binding-protein-dependent transport systems inner membrane Component COG4132 Cluster_603533 V1284969 FTSI map00550,map01100 M penicillin-binding protein COG0768 Cluster_603534 V1284972 S Phage infection protein COG1511 Cluster_603535 V1284973 LDH map00010,map00270,map00620,map00640,map01100,map01110,map01120 C L-lactate dehydrogenase COG0039 Cluster_748357 V1284975 map00350,map00362,map00540,map00627,map00642,map00903,map01100,map01120 M lipid A biosynthesis acyltransferase COG4261 Cluster_649266 V1284976 map00040,map00051,map01100 G xylose isomerase COG4952 Cluster_603536 V1284977 DPPB map02010 P ABC transporter (Permease) COG0601 Cluster_599982 V1284979 P TonB-dependent receptor plug 0XNNV Cluster_599983 V1284980 K anti-repressor COG3645 Cluster_599984 V1284981 YCLM map00260,map00270,map00300,map01100,map01110,map01120,map01210,map01230 E Aspartokinase COG0527 Cluster_653353 V1284982 DGKA map00561,map00564,map01100,map04070 M Diacylglycerol kinase COG0818 Cluster_599985 V1284983 S NA 0XU4E Cluster_674585 V1284984 AATB map02010 E ABC transporter substrate-binding protein COG0834 Cluster_836446 V1284985 SSNA map00791,map01100,map01120 F Chlorohydrolase aminohydrolase COG0402 Cluster_599986 V1284987 HSDR V Type I Restriction COG0610 Cluster_603537 V1284988 S sialic acid-specific 9-O-acetylesterase 0XQ2Q Cluster_603538 V1284989 PSTA map02010 P phosphate abc transporter COG0581 Cluster_629410 V1284990 SRTB U sortase, SrtB family COG4509 Cluster_603539 V1284991 K Transcriptional regulator COG1609 Cluster_599987 V1284992 BAPKO_0207 P CBS domain protein COG1253 Cluster_603540 V1284993 YABB map00340,map00350,map00624,map01120 L Methyltransferase COG4123 Cluster_599988 V1284994 SUFB O FeS assembly protein SUFB COG0719 Cluster_599989 V1284995 YFAL M, U outer membrane autotransporter COG3468 Cluster_599990 V1284996 RLUD J Pseudouridine synthase COG0564 Cluster_688024 V1284997 T response regulator COG2208 Cluster_649267 V1284999 map00230,map00240,map00760,map01100,map01110 F 5'-nucleotidase COG0737 Cluster_599991 V1285000 V Type II restriction m6 adenine DNA methyltransferase, Alw26I Eco31I Esp3I family 125HB Cluster_599992 V1285001 S NA 11P3R Cluster_599993 V1285003 SP_0791 map00051,map00363,map00591,map00625,map00650,map01100,map01120 C Aldo Keto reductase COG4989 Cluster_603541 V1285005 YYBT T domain protein COG3887 Cluster_637292 V1285007 S NA 0XU7P Cluster_657476 V1285008 T Y_Y_Y domain COG3706 Cluster_599994 V1285009 SP_0498 map00511 G endo-beta-N-acetylglucosaminidase COG4724 Cluster_603542 V1285010 PYRD map00240,map01100 F Catalyzes the conversion of dihydroorotate to orotate (By similarity) COG0167 Cluster_599995 V1285011 map00190,map00910,map01100 C hydrogenase) (Fe-only COG4624 Cluster_859946 V1285013 INTA L Integrase COG0582 Cluster_809455 V1285014 K Transcriptional regulator COG1846 Cluster_599999 V1285019 S NA 0ZVM0 Cluster_600000 V1285021 MURC map00471,map00473,map00550,map01100 M Cell wall formation (By similarity) COG0773 Cluster_600001 V1285022 TKTA2 map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase COG3959 Cluster_755264 V1285024 S NA 11EE9 Cluster_603544 V1285028 DDL map00473,map00550,map01100 M Cell wall formation (By similarity) COG1181 Cluster_653354 V1285030 AHPC O C-terminal domain of 1-Cys peroxiredoxin COG0450 Cluster_603545 V1285031 L Virulence-associated protein e COG5545 Cluster_728464 V1285032 ILVM map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E Acetolactate synthase 2 regulatory subunit COG3978 Cluster_731739 V1285035 NFUA O Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) COG0694 Cluster_692445 V1285036 YEAB P cation diffusion facilitator family transporter COG0053 Cluster_629412 V1285037 GLTD map00250,map00910,map01100,map01110,map01120,map01230 E Glutamate synthase COG0493 Cluster_748358 V1285038 FABH map00061,map01100 I synthase III COG0332 Cluster_603546 V1285039 map00010,map00071,map00350,map00362,map00620,map00621,map00622,map00625,map00626,map00650,map01100,map01110,map01120 C Dehydrogenase COG1454 Cluster_670204 V1285041 CITE map00020,map01110,map02020 C Citrate lyase subunit beta COG2301 Cluster_600003 V1285042 SBM map00280,map00630,map00640,map00720,map01100,map01120 I Methylmalonyl-coA mutase COG2185 Cluster_665881 V1285043 GLYQ map00970 J glycyl-tRNA synthetase, alpha subunit COG0752 Cluster_600004 V1285044 M phosphoglycerol transferase COG1368 Cluster_679026 V1285045 S conserved domain protein 11Q3F Cluster_603547 V1285046 S NA 10P7J Cluster_603548 V1285047 S NA 11NI8 Cluster_600005 V1285048 ERH_0171 L transposase COG2826 Cluster_731740 V1285049 YJGR S ATP-binding protein COG0433 Cluster_603549 V1285050 GLCK map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G ROK family COG1940 Cluster_600006 V1285052 XDHD map00230,map00450,map01100,map01120 C Xanthine dehydrogenase COG1529 Cluster_603550 V1285053 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_777638 V1285054 S NA 11NI8 Cluster_600007 V1285055 O cysteine protease COG4870 Cluster_821085 V1285056 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_603551 V1285057 YCHF J gtp-binding protein COG0012 Cluster_600008 V1285058 RSMD map00340,map00350,map00624,map01120 L methyltransferase COG0742 Cluster_828827 V1285059 YOZG K Transcriptional regulator COG3655 Cluster_600009 V1285061 P TonB dependent receptor 0XNNV Cluster_600010 V1285062 GSPE map03070 U type II secretion system protein E COG2804 Cluster_603552 V1285063 RNFB C electron transport complex, RnfABCDGE type, B subunit COG2878 Cluster_603553 V1285065 T cyclic nucleotide-binding domain protein COG0664 Cluster_603554 V1285066 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_618272 V1285067 GLMM map00520,map01100 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 Cluster_603555 V1285068 NAGB map00520,map01100,map01110 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COG0363 Cluster_603556 V1285069 S integral membrane protein 0XS1S Cluster_618273 V1285070 RIBE map00740,map01100 H riboflavin synthase, subunit alpha COG0307 Cluster_603557 V1285071 RAHAQ_0099 L Transposase IS116 IS110 IS902 COG3547 Cluster_600011 V1285072 SPSC map00362,map00363,map00520,map00626,map00650,map00903,map01100,map01110,map01120,map02020 M Polysaccharide biosynthesis protein COG0399 Cluster_603558 V1285073 BH0416 L Transposase COG3464 Cluster_600012 V1285074 CG2937 E Extracellular solute-binding protein, family 5 COG0747 Cluster_600013 V1285075 S Protein of unknown function (DUF541) 0YM36 Cluster_731741 V1285076 NHAC map00680 C Na H antiporter COG1757 Cluster_603559 V1285078 RV3193C S UPF0182 protein COG1615 Cluster_603560 V1285079 map00010,map00071,map00350,map00561,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120 C alcohol dehydrogenase COG1454 Cluster_696191 V1285080 YIDE P transport protein COG2985 Cluster_625699 V1285081 S phage plasmid primase, p4 family COG3378 Cluster_657477 V1285082 ASNS map00970 J asparaginyl-tRNA synthetase COG0017 Cluster_692446 V1285083 EPC_04680 S N-6 DNA Methylase 11HFP Cluster_603561 V1285084 TREY map00500,map01100,map01110 G malto-oligosyltrehalose synthase COG3280 Cluster_603562 V1285085 E Glutamate synthase central domain COG0069 Cluster_603563 V1285087 S NA 0XS0Q Cluster_603564 V1285088 S Radical SAM superfamily COG0641 Cluster_751792 V1285089 S Membrane COG2323 Cluster_603565 V1285090 S integral membrane protein 0XS1S Cluster_661676 V1285094 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_603568 V1285095 UHPT P Major Facilitator COG0477 Cluster_657478 V1285096 S surface layer protein 0ZYVX Cluster_603569 V1285098 AMAA map00360 E amidohydrolase COG1473 Cluster_603570 V1285099 S NA 0YYNW Cluster_603571 V1285100 PPDK map00620,map00710,map01100,map01120 G pyruvate phosphate dikinase COG0574 Cluster_629413 V1285101 map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_773934 V1285102 ATPG map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) COG0224 Cluster_603572 V1285105 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_653355 V1285106 PROC map00330,map01100,map01110,map01230 E pyrroline-5-carboxylate reductase COG0345 Cluster_610784 V1285107 FFH map03060,map03070 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 Cluster_603573 V1285108 S Inherit from NOG: Phosphate-Selective Porin O and P 0XQB1 Cluster_603574 V1285109 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_603575 V1285110 S NA 11MG2 Cluster_653356 V1285112 TRPS map00970 J Tryptophanyl-tRNA synthetase COG0180 Cluster_603576 V1285113 S peptidase u35 phage prohead 17A1F@proNOG Cluster_649268 V1285114 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E brancheD-chain amino acid aminotransferase COG0115 Cluster_603577 V1285115 PRMC map00340,map00350,map00624,map01120 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 Cluster_603578 V1285116 THIT S Proton-coupled thiamine transporter YuaJ COG3859 Cluster_603579 V1285117 TOLC map03070,map04626,map05133 M type I secretion outer membrane protein COG1538 Cluster_692447 V1285118 S NA 0Y0N4 Cluster_637293 V1285119 AGCS E Sodium:alanine symporter family COG1115 Cluster_603580 V1285120 UGE map00052,map00500,map00520,map01100,map01110 G, M Male sterility protein COG0451 Cluster_603581 V1285121 P phosphate-selective porin O and P COG3746 Cluster_696192 V1285122 DCM map00270,map01100 L Cytosine-specific methyltransferase COG0270 Cluster_603582 V1285123 YBBP S TIGR00159 family COG1624 Cluster_603583 V1285124 S Transporter, auxin efflux carrier (AEC) family protein COG0679 Cluster_603584 V1285125 LIPB map00785,map01100 H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) COG0321 Cluster_738308 V1285128 YOJN S ATPase associated with various cellular activities aaa_5 COG0714 Cluster_603586 V1285130 PURD map00230,map01100,map01110 F Phosphoribosylglycinamide synthetase COG0151 Cluster_711867 V1285131 S ABC-type dipeptide transport system periplasmic component 0XPRS Cluster_603587 V1285132 L Site-specific recombinase, phage integrase family 11F8N Cluster_653357 V1285133 ARGH map00250,map00330,map01100,map01110,map01230 E arginosuccinase COG0165 Cluster_603588 V1285134 map02010 P ABC transporter 0XQHT Cluster_603589 V1285135 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_762591 V1285136 P Rhodanese domain protein COG0607 Cluster_708669 V1285137 DNAQ map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase iii, epsilon subunit COG0847 Cluster_603590 V1285138 S repeat protein 11IAG Cluster_603591 V1285139 GLTD map00250,map00450,map00910,map01100,map01110,map01120,map01230 E Involved in pyrimidine base degradation. Catalyzes physiologically the reduction of uracil to 5,6-dihydrouracil (DHU) by using NADH as a specific cosubstrate. It also catalyzes the reverse reaction and the reduction of thymine to 5,6- dihydrothymine (DHT) COG0493 Cluster_614518 V1285140 S F420-0:Gamma-glutamyl ligase 0Y085 Cluster_603592 V1285141 CLFA map05150 M Cell surface-associated protein implicated in virulence. Promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen. Induces formation of bacterial clumps 0Y59N Cluster_603593 V1285143 NRDE map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_603594 V1285144 MUCPA_0453 L Transposase COG3328 Cluster_702491 V1285145 YBHF V ABC, transporter COG1131 Cluster_603595 V1285146 CLPB O ATP-dependent chaperone ClpB COG0542 Cluster_751793 V1285149 MSBA map02010 V ABC transporter transmembrane region COG1132 Cluster_603596 V1285150 PBP2A map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_603597 V1285151 L phage plasmid primase, p4 family COG3378 Cluster_607142 V1285152 S tail fiber protein COG5301 Cluster_607143 V1285153 S tonB-dependent Receptor 0XNVP Cluster_607144 V1285154 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_674587 V1285156 S NA 11KQ4 Cluster_603598 V1285157 map00190,map00630,map00680,map00910,map01100,map01120 C NADH dehydrogenase (quinone) (EC 1.6.99.5) COG1894 Cluster_625700 V1285159 BMUL_4862 S late control COG3500 Cluster_844426 V1285160 PPSA S pyruvate phosphate dikinase 0XRDW Cluster_705595 V1285161 RPLR map03010 J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) COG0256 Cluster_670205 V1285162 S NA 122IS Cluster_603600 V1285163 HPRK T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) COG1493 Cluster_607145 V1285164 map05100 S repeat protein 11TEE Cluster_868188 V1285167 LIVH map02010 E Branched-chain amino acid transport system permease protein COG0559 Cluster_607146 V1285168 ARGE E peptidase COG0624 Cluster_603602 V1285169 PFLB map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_607147 V1285170 ATPA map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_821086 V1285171 P efflux transporter, rnd family, mfp subunit 0XSAD Cluster_603603 V1285172 PFLB map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_603604 V1285174 SPOU J rrna methyltransferase COG0566 Cluster_725144 V1285175 K transcriptional regulator COG1609 Cluster_852110 V1285177 S domain protein COG1917 Cluster_738309 V1285178 ENGB S Necessary for normal cell division and for the maintenance of normal septation (By similarity) COG0218 Cluster_888382 V1285179 RPLT map03010 J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) COG0292 Cluster_817189 V1285180 RPMI map03010 J 50s ribosomal protein L35 COG0291 Cluster_607148 V1285181 RNJA map03018 O Metallo-Beta-Lactamase COG0595 Cluster_884469 V1285182 S NA 187CD@proNOG Cluster_621917 V1285183 PRDD map00330 S D-proline reductase 0ZP81 Cluster_817190 V1285184 GLUD map00250,map00330,map00430,map00471,map00910,map01100,map04964 E Glutamate dehydrogenase COG0334 Cluster_607149 V1285185 PNTB map00760,map01100 C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) COG1282 Cluster_603605 V1285186 G deacetylase COG0726 Cluster_603606 V1285187 AMT P ammonium transporter COG0347 Cluster_683593 V1285188 NTPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_607150 V1285189 S NA 0Y9Z0 Cluster_610785 V1285192 XYLE G transporter 0XNQK Cluster_603607 V1285193 V ABC, transporter COG0577 Cluster_755265 V1285194 S NA 0ZPA4 Cluster_603608 V1285196 map02010 S YodA lipocalin-like domain 11KBP Cluster_607151 V1285198 PEPD E Dipeptidase COG4690 Cluster_696193 V1285200 S Protein of unknown function (DUF464) 0XV7X Cluster_603609 V1285201 RSGA G May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) COG1162 Cluster_789531 V1285202 M Catalyzes the conversion of a range of fructosamine 6- phosphates to glucose 6-phosphate and a free amino acid (By similarity) COG2222 Cluster_603610 V1285207 BGLB map00460,map00500,map00940,map01100,map01110 G Glycosyl hydrolase family 3 C-terminal domain COG1472 Cluster_625701 V1285208 FATD map02010 P permease protein COG4606 Cluster_777640 V1285210 P19 P Periplasmic Protein COG3470 Cluster_603611 V1285211 SBP map02010 P Sulfate ABC transporter periplasmic sulfate-binding protein COG1613 Cluster_607152 V1285212 E Family 5 COG0747 Cluster_785532 V1285214 S NA 11MCJ Cluster_607153 V1285215 K HTH_XRE 0XU1P Cluster_637294 V1285216 YBHL S Membrane COG0670 Cluster_603612 V1285218 G extracellular solute-binding protein family 1 0XQSR Cluster_607154 V1285219 T response regulator receiver and sarp domain-containing protein 11QE4 Cluster_607155 V1285220 EUTS E utilization protein COG4810 Cluster_603613 V1285221 map02020,map02030 N, T Methyl-accepting chemotaxis COG0840 Cluster_607156 V1285222 COMM O Mg chelatase subunit ChlI COG0606 Cluster_607157 V1285223 YCGA S c4-dicarboxylate anaerobic carrier COG1288 Cluster_721796 V1285225 E amidohydrolase COG1473 Cluster_777641 V1285226 PBUG S Xanthine uracil vitamin C permease COG2252 Cluster_607158 V1285227 PGK map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Phosphoglycerate kinase COG0126 Cluster_618274 V1285228 RBR C Rubrerythrin COG1853 Cluster_603614 V1285229 RPSC map03010 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 Cluster_607159 V1285230 COMEC S DNA internalization-related competence protein ComEC Rec2 COG2333 Cluster_603615 V1285231 TKT map00030,map00710,map01051,map01100,map01110,map01120,map01230 G Transketolase (EC 2.2.1.1) COG0021 Cluster_649269 V1285232 LEPB map03060 U Signal peptidase i COG0681 Cluster_614519 V1285234 SECY map03060,map03070 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 Cluster_603616 V1285237 S NA 0XRV2 Cluster_696194 V1285238 CSM4 L CRISPR-associated RAMP protein, Csm4 family COG1567 Cluster_607162 V1285239 NAGA map00520,map01110 G GlcNAc 6-P deacetylase COG1820 Cluster_607163 V1285241 O cysteine protease COG4870 Cluster_661677 V1285242 S NA 12D6A Cluster_603617 V1285243 PEPI map00330 E Releases the N-terminal proline from various substrates (By similarity) COG0596 Cluster_603618 V1285244 ADDB L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination COG3857 Cluster_614520 V1285245 AMID map02010 E, P ABC transporter, permease protein COG1173 Cluster_603619 V1285247 S Rhomboid family 0ZEJ4 Cluster_781459 V1285248 XKDT S baseplate J family protein COG3299 Cluster_607165 V1285250 S Protein of unknown function (DUF3160) 0XRJH Cluster_607166 V1285251 MCSB map00330 E ATP guanido phosphotransferase COG3869 Cluster_762592 V1285252 LYS1 map00300,map00310,map01100,map01110,map01230 E saccharopine dehydrogenase COG1748 Cluster_785533 V1285253 MENA map00130,map01100,map01110 H 1,4-dihydroxy-2-naphthoate octaprenyltransferase COG1575 Cluster_711868 V1285255 RPE map00030,map00040,map00710,map01100,map01110,map01120,map01230 G ribulose-phosphate 3-epimerase COG0036 Cluster_731742 V1285256 TCYC map02010 E ABC transporter, ATP-binding protein COG1126 Cluster_758776 V1285257 U, W Pfam:Hep_Hag COG5295 Cluster_900968 V1285258 DINB2 L ImpB MucB SamB family protein COG0389 Cluster_618275 V1285260 TIG O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COG0544 Cluster_607168 V1285261 GAP map00010,map01100,map01110,map01120,map01230,map04066,map05010 G Glyceraldehyde-3-phosphate dehydrogenase, type I COG0057 Cluster_607169 V1285262 S NA 0XZ4Z Cluster_607170 V1285263 COMB map02020,map03070,map05133 U Transport protein ComB 0XX01 Cluster_607171 V1285265 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_629414 V1285266 CSTA T carbon starvation protein COG1966 Cluster_607173 V1285268 V FtsX-like permease family 0ZW5X Cluster_607174 V1285269 SECA map03060,map03070 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 Cluster_607175 V1285270 MSMEG_1055 map00350,map00362,map00627,map00642,map00903,map01120 S acetyltransferase COG0110 Cluster_607177 V1285274 NTPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_607178 V1285275 S pectate lyase 0XQBW Cluster_607179 V1285276 SUSC P outer membrane protein SusC 0XNNV Cluster_813462 V1285277 map02010 P abc-3 protein COG1108 Cluster_607180 V1285278 MNME S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 Cluster_607181 V1285279 M Outer membrane protein, OMP85 family 0XNPU Cluster_607182 V1285280 YOEA V Mate efflux family protein COG0534 Cluster_607183 V1285281 S domain protein COG5012 Cluster_748359 V1285282 UPPP map00550 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) COG1968 Cluster_607184 V1285283 MRCA map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_657479 V1285287 KDGK map00030,map00040,map01100,map01120 G pfkb domain protein COG0524 Cluster_855882 V1285288 NTH map03410 L endonuclease III COG0177 Cluster_748360 V1285290 THIT S Proton-coupled thiamine transporter YuaJ COG3859 Cluster_607186 V1285292 HPRA map00260,map00630,map00680,map01100,map01110,map01120 C Dehydrogenase COG1052 Cluster_607187 V1285293 GLNA map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG0174 Cluster_607188 V1285294 V Mate efflux family protein COG1151 Cluster_840385 V1285295 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_607189 V1285296 CSN1 L CRISPR-associated protein, Csn1 family COG3513 Cluster_758777 V1285297 FSAB map00030,map01100,map01110,map01120,map01230 G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) COG0176 Cluster_770249 V1285300 PNCB map00760,map01100 H Nicotinate phosphoribosyltransferase COG1488 Cluster_809456 V1285301 SBCD L SbcCD D subunit COG0420 Cluster_935421 V1285302 HISN map00340,map00521,map00562,map01100,map01110,map01230,map04070 E histidinol-phosphate phosphatase COG0483 Cluster_641282 V1285303 TRAM S Conjugative transposon TraM protein 0XQI8 Cluster_607190 V1285304 S NA 0YEAQ Cluster_607192 V1285306 L Inherit from COG: transposase COG3666 Cluster_607193 V1285307 K transcriptional attenuator COG1316 Cluster_607194 V1285308 ACRB P heavy metal efflux pump, CzcA family COG0841 Cluster_762593 V1285309 S NA 11RBN Cluster_607196 V1285311 CYDC map02010 V ABC transporter, ATP-binding protein COG1132 Cluster_607197 V1285312 DEGP map02020 O peptidase S1 and S6, chymotrypsin Hap COG0265 Cluster_607199 V1285314 S NA 101UU Cluster_607200 V1285315 OPPC2 E, P ABC superfamily ATP binding cassette transporter, membrane protein COG1173 Cluster_607201 V1285316 NTH map03410 L endonuclease III COG0177 Cluster_607203 V1285318 CBPA map00500 G Glycosyltransferase 36 COG3459 Cluster_751795 V1285322 NUOB map00190,map00910,map01100 C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) COG0377 Cluster_705596 V1285323 S NA 0ZMX8 Cluster_607205 V1285324 CTPA M protease COG0793 Cluster_621918 V1285325 PEPR map00310,map00780,map01100 O peptidase m16 domain-containing protein COG0612 Cluster_607206 V1285326 UPPP map00550 V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) COG1968 Cluster_607207 V1285328 S NA 0XRQD Cluster_607208 V1285329 S Lpxtg-motif cell wall anchor domain protein 0XQBH Cluster_629415 V1285332 map00520,map01110 G BadF BadG BcrA BcrD COG2971 Cluster_801269 V1285333 OCAR_6752 H DNA integration recombination invertion protein COG1636 Cluster_607209 V1285335 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_670206 V1285336 VPA1266 map03440 L Helicase, RecD TraA family COG0507 Cluster_607210 V1285337 DNAA map02020,map04112 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 Cluster_607211 V1285338 S NA 0YNDQ Cluster_607212 V1285339 FTSI map00550 M penicillin-binding protein COG0768 Cluster_641283 V1285342 S NA 11KPU Cluster_872192 V1285344 SP_0073 S glyoxalase COG2514 Cluster_625702 V1285345 WECB map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_610786 V1285348 PRTA O peptidase S8 and S53, subtilisin, kexin, sedolisin COG5492 Cluster_607215 V1285349 MIAB J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) COG0621 Cluster_610787 V1285350 P TonB dependent receptor 0XNNV Cluster_607216 V1285351 FADD map00071,map01100,map03320,map04146,map04920 I Long-chain-fatty-acid--CoA ligase COG1022 Cluster_610788 V1285352 map02010 E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COG3842 Cluster_607217 V1285353 BAMA map00061,map00780,map01100 M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane COG4775 Cluster_610789 V1285354 L plasmid recombination enzyme 0YFB8 Cluster_610790 V1285355 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin COG1404 Cluster_607218 V1285357 U, W surface protein COG5295 Cluster_725145 V1285359 HRCA K heat-inducible transcription repressor COG1420 Cluster_607219 V1285360 AGAB3 map00052,map00561,map00600,map00603 G alpha-galactosidase COG3345 Cluster_692450 V1285361 SSCG_03030 map02010 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 Cluster_610791 V1285362 DPPF E ABC transporter COG4608 Cluster_762594 V1285363 HISK map00340,map01100,map01110,map01230 E histidinol phosphate phosphatase, hisj family COG1387 Cluster_607220 V1285364 L Transposase 1012J Cluster_610792 V1285365 O peptidase, M48 COG0501 Cluster_688027 V1285366 G hydrolase family 18 COG3858 Cluster_607221 V1285367 G glycosidase COG2152 Cluster_738310 V1285372 TMK map00240,map01100 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) COG0125 Cluster_725146 V1285373 ETFB map00910 C Electron transfer flavoprotein COG2086 Cluster_625703 V1285374 MURI map00230,map00240,map00471,map01100 M Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) COG0796 Cluster_641284 V1285375 S NA 0YKK7 Cluster_607222 V1285376 PGCA map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 Cluster_610793 V1285377 S NA 0XYQ4 Cluster_610794 V1285378 PTSF map00051,map01100,map02060 G PTS System COG1445 Cluster_607224 V1285381 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_607225 V1285382 CARB map00240,map00250,map01100 F carbamoyl-phosphate synthetase ammonia chain COG0458 Cluster_607226 V1285383 LIGA map03030,map03410,map03420,map03430 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 Cluster_708671 V1285386 S NA 0XW6Q Cluster_610795 V1285387 YGCG S of methanol dehydrogenase type COG1512 Cluster_607227 V1285389 YOCR P Transporter COG0733 Cluster_852111 V1285390 MAZF T Toxic component of a toxin-antitoxin (TA) module (By similarity) COG2337 Cluster_715236 V1285392 map02010 P ABC transporter COG0395 Cluster_734982 V1285394 S Protein of unknown function (DUF2874) 0YKIR Cluster_610798 V1285396 S NA 0Y0MV Cluster_692451 V1285397 S Transposase domain (DUF772) 10J45 Cluster_610799 V1285399 HSDA V DNA specificity domain protein COG0732 Cluster_610800 V1285401 D Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) COG0037 Cluster_607228 V1285404 GLND map02020 O Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) COG2844 Cluster_844427 V1285405 APEA map00480,map01100 E M18 family aminopeptidase COG1362 Cluster_610803 V1285406 YQEK map00760,map01100 H Metal Dependent Phosphohydrolase COG1713 Cluster_610804 V1285407 SSCG_05191 S conserved protein UCP033563 COG4198 Cluster_649270 V1285408 SKP M Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) COG2825 Cluster_683595 V1285409 GYRB L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 Cluster_607229 V1285411 RBSA map02010 P ABC transporter COG1129 Cluster_610805 V1285412 PUTA map00250,map00330,map01100,map01110 C Dehydrogenase COG1012 Cluster_610806 V1285413 PURM map00230,map01100,map01110 F phosphoribosylaminoimidazole synthetase COG0150 Cluster_661680 V1285415 XTH map03410 L Exodeoxyribonuclease III COG0708 Cluster_745016 V1285417 FABF3 map00061,map00780,map01100 I, Q synthase COG0304 Cluster_607230 V1285418 FIXC map00910 C electron transfer flavoprotein-ubiquinone oxidoreductase COG0644 Cluster_699462 V1285419 MNME S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 Cluster_661682 V1285421 S Tetratricopeptide repeat protein 0XZXZ Cluster_607231 V1285422 S Protein of unknown function (DUF3575) 11SXP Cluster_610807 V1285424 YJIK S sdia-regulated domain-containing protein COG3204 Cluster_610808 V1285425 P Sodium/hydrogen exchanger family COG0475 Cluster_607232 V1285426 map00680 C Na H antiporter COG1757 Cluster_610809 V1285427 FTSH O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_610810 V1285428 CDR map00190 P pyridine nucleotide-disulfide oxidoreductase COG0607 Cluster_801270 V1285431 MALH map00010,map00500 G glycoside hydrolase family 4 COG1486 Cluster_610811 V1285433 S NA 0ZEZ9 Cluster_610812 V1285434 YNGI map00071,map01100,map03320,map04146,map04920 I amp-dependent synthetase and ligase COG0318 Cluster_610813 V1285435 YQFL S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) COG1806 Cluster_649271 V1285436 ADCC map02010 P ABC transporter COG1121 Cluster_610814 V1285438 WCHF M Glycosyl transferase (Group 1 0XPWD Cluster_610815 V1285439 P tonB-dependent Receptor 0XNNV Cluster_618276 V1285440 P TonB-dependent receptor 1AHK2@sphNOG Cluster_610816 V1285441 O Inherit from COG: peptidase (S8 and S53, subtilisin, kexin, sedolisin 0XQTW Cluster_607233 V1285442 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_607234 V1285444 WLAB map02010 V ABC transporter, ATP-binding protein COG1132 Cluster_699463 V1285445 K RNA Polymerase COG1595 Cluster_674589 V1285447 O Thioredoxin COG0526 Cluster_607235 V1285448 YICE F permease COG2233 Cluster_610818 V1285449 map00564 S NA 11NI7 Cluster_610819 V1285450 map02010 P binding-protein-dependent transport systems inner membrane Component COG1178 Cluster_610820 V1285451 GLTX map00860,map00970,map01100,map01110 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 Cluster_610823 V1285454 S Domain of unknown function (DUF348) COG3583 Cluster_610824 V1285456 S NA 124ZQ Cluster_610825 V1285457 TOPB L Dna topoisomerase COG0550 Cluster_610826 V1285458 DNAG map03030 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 Cluster_610827 V1285459 S tetratricopeptide repeat 0ZZIS Cluster_610828 V1285461 T response regulator COG0745 Cluster_610829 V1285462 GLNS map00970,map01100 J glutaminyL-tRNA synthetase COG0008 Cluster_610830 V1285463 SP_2145 G Alpha-1,2-mannosidase COG3537 Cluster_625704 V1285464 RSFS S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) COG0799 Cluster_610831 V1285465 P TonB-dependent Receptor Plug Domain 0YD5U Cluster_610832 V1285467 FADD35 map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG0318 Cluster_610833 V1285468 OPPCD E, P abc transporter COG1173 Cluster_610834 V1285470 G Inherit from bactNOG: transporter COG2211 Cluster_610835 V1285471 YIEG S Xanthine uracil vitamin C permease COG2252 Cluster_610836 V1285474 NDHF map00190,map00910,map01100 C Proton-translocating NADH-quinone oxidoreductase, chain L COG1009 Cluster_745017 V1285475 S NA 0ZSVM Cluster_610837 V1285476 DACB map00550 M d-alanyl-d-alanine carboxypeptidase COG2027 Cluster_610838 V1285477 HPRA map00260,map00620,map00630,map00680,map01100,map01110,map01120 C Dehydrogenase COG1052 Cluster_610840 V1285482 MAF D Maf-like protein COG0424 Cluster_610841 V1285483 LDTA S ErfK YbiS YcfS YnhG COG1376 Cluster_610842 V1285484 S NA 11VIE Cluster_610843 V1285485 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_610844 V1285486 XPT map00230,map01100,map01110 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) COG0503 Cluster_801271 V1285489 PHOP map02020 T Transcriptional regulatory protein cutR (Defective melC1 suppressor protein) 11FPD Cluster_696196 V1285490 map00190,map00910,map01100 C -hydrogenase COG4624 Cluster_645161 V1285493 XPT map00230,map01100,map01110 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) COG0503 Cluster_840388 V1285494 S NA 11SUR Cluster_610845 V1285495 CAPA M Capsule synthesis protein COG2843 Cluster_641285 V1285496 TATC map03060,map03070 U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) COG0805 Cluster_610846 V1285497 S NA 1259Q Cluster_610847 V1285499 S Protein of unknown function (DUF2812) 11ZMJ Cluster_610848 V1285500 O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 Cluster_610849 V1285501 S YycH protein 0ZZRJ Cluster_610850 V1285503 NUPG G nucleoside 0ZVFU Cluster_844429 V1285504 MSRA O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) COG0225 Cluster_661683 V1285505 T anti-sigma regulatory factor serine threonine protein kinase 11VVV Cluster_848314 V1285506 K Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) COG1521 Cluster_825051 V1285507 SP_1232 S Membrane COG4684 Cluster_610852 V1285510 RECD map03440 L Helicase, RecD TraA family COG0507 Cluster_832629 V1285511 TCYB map02010 E amino acid ABC transporter COG0765 Cluster_614521 V1285512 GLPT map02020 G transporter COG2271 Cluster_610853 V1285513 S NA 0XRP2 Cluster_702494 V1285514 CEFD map00311,map01100,map01110 E aminotransferase class V COG0520 Cluster_715237 V1285516 ECHA6 map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120 I Enoyl-CoA hydratase COG1024 Cluster_876312 V1285517 YMDB S appr-1-p processing domain protein COG2110 Cluster_610854 V1285519 AGUA G Alpha-glucuronidase (EC 3.2.1.139) COG3661 Cluster_614522 V1285520 GLGP map00500,map01100,map01110,map04910 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG0058 Cluster_614523 V1285521 HSDM V Type I restriction-modification system, M subunit COG0286 Cluster_614524 V1285522 D ATP-binding protein COG0489 Cluster_610855 V1285523 S Protein of unknown function (DUF401) 0YXXI Cluster_785534 V1285524 K GntR family transcriptional regulator COG2188 Cluster_610856 V1285525 ATPG map00190,map00195,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) COG0224 Cluster_610857 V1285527 PRS map00030,map00230,map01100,map01110,map01120,map01230 F Ribose-phosphate pyrophosphokinase COG0462 Cluster_614526 V1285528 HEMN map00860,map01100,map01110 H Coproporphyrinogen iii oxidase COG0635 Cluster_738311 V1285529 AFUA map02010 P ABC transporter COG1840 Cluster_699464 V1285532 PAAK map00360,map01120 Q phenylacetate-coenzyme A ligase COG1541 Cluster_876313 V1285533 map02010,map02030 G Periplasmic binding protein LacI transcriptional regulator COG1879 Cluster_610858 V1285534 MSRB O reductase COG0229 Cluster_633231 V1285535 S NA 11W2F Cluster_699465 V1285536 RLMN J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs COG0820 Cluster_645162 V1285538 S NA 0YEF7 Cluster_610859 V1285539 S fad dependent oxidoreductase COG2509 Cluster_614527 V1285540 S Bacterial mobilisation protein (MobC). Ribbon-helix-helix protein, copG family 0Y5MJ Cluster_728466 V1285542 K Transcriptional regulator 11XE1 Cluster_813463 V1285544 S NA 101GK Cluster_679028 V1285545 PEPE map00480,map01100 E peptidase S51, dipeptidase E COG3340 Cluster_751797 V1285546 METI map02010 P ABC transporter, permease COG2011 Cluster_614528 V1285549 TRKA P potassium transporter peripheral membrane COG0569 Cluster_610860 V1285551 DUSB J Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) COG0042 Cluster_610861 V1285552 G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) COG1640 Cluster_610862 V1285553 DPPD E, P (ABC) transporter COG0444 Cluster_610863 V1285554 RPLP map03010 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 Cluster_661684 V1285555 S copper amine 121X1 Cluster_614529 V1285556 NUOJ map00190,map00910,map01100 C NADH dehydrogenase subunit j COG0839 Cluster_610864 V1285557 S type III effector, Hrp-dependent COG3395 Cluster_614530 V1285558 S NA 0YSGI Cluster_614531 V1285559 ACKA map00430,map00620,map00640,map00680,map00720,map01100,map01120 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 Cluster_633232 V1285561 PURF map00230,map00250,map01100,map01110 F amidophosphoribosyltransferase (EC 2.4.2.14) COG0034 Cluster_610865 V1285562 DER map00260,map00680,map01100,map01120,map01230 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 Cluster_610866 V1285564 RECF map03440 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 Cluster_614533 V1285566 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_745018 V1285567 O ADP-ribosylglycohydrolase COG1397 Cluster_614535 V1285569 L Transposase 1012J Cluster_797293 V1285570 T response regulator COG0745 Cluster_610867 V1285571 RAGA P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_610868 V1285572 V ABC transporter COG1132 Cluster_657480 V1285573 NAGA map00052,map00520,map01110 G GlcNAc 6-P deacetylase COG1820 Cluster_614536 V1285574 V Mate efflux family protein COG0534 Cluster_715238 V1285575 BCD map00071,map00280,map00281,map00650,map01100,map01110 I acyl-CoA dehydrogenase COG1960 Cluster_610869 V1285576 MGLA map02010 G ATP-binding protein COG1129 Cluster_813464 V1285578 S NA 0YZJM Cluster_741708 V1285580 Y2214 K Antirepressor COG3645 Cluster_610870 V1285581 EFEU map00020,map00720,map01100,map01110,map01120,map05200,map05211 P iron permease COG0672 Cluster_614538 V1285585 K PRD domain COG3711 Cluster_610871 V1285586 S Cytosolic protein COG4913 Cluster_614539 V1285587 COPA P p-type ATPase COG2217 Cluster_614540 V1285588 L DNA helicase COG1112 Cluster_614541 V1285591 FOLC map00790,map01100 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 Cluster_731743 V1285592 OCAR_6752 H DNA integration recombination invertion protein COG1636 Cluster_610872 V1285593 map00051,map00511,map00520,map00531,map00603,map00604,map01100,map01110,map04142 G ec 3.2.1.52 COG3525 Cluster_610873 V1285595 P TonB-dependent receptor Plug 0XNPQ Cluster_614542 V1285596 PFKA map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G Phosphohexokinase COG0205 Cluster_614543 V1285597 RPE map00030,map00040,map00710,map01100,map01110,map01120,map01230 G ribulose-phosphate 3-epimerase COG0036 Cluster_610874 V1285598 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_610875 V1285599 LEPA map05134 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 Cluster_614544 V1285600 LIPL48 S (LipO)protein 0XQ4U Cluster_801272 V1285601 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_766540 V1285603 MGTE P magnesium transporter COG2239 Cluster_614546 V1285604 S ATPase (AAA COG1373 Cluster_610876 V1285605 PVDS map00190,map03018 L polyphosphate kinase 2 COG2326 Cluster_610877 V1285606 MUTS2 L DNA mismatch repair protein COG0249 Cluster_614547 V1285608 YJGR S ATP-binding protein COG0433 Cluster_621920 V1285609 PYRH map00240,map01100 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 Cluster_614549 V1285611 V Mate efflux family protein COG0534 Cluster_785536 V1285612 CYSK map00270,map00920,map01100,map01120,map01230 E Pyridoxal-phosphate dependent enzyme COG0031 Cluster_610878 V1285613 YYBT T domain protein COG3887 Cluster_859949 V1285614 map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120 C 2-oxoglutarate ferredoxin oxidoreductase subunit alpha COG0674 Cluster_813465 V1285615 PORC map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120 C oxidoreductase gamma subunit COG1014 Cluster_610879 V1285616 RNFB C electron transport complex, RnfABCDGE type, B subunit COG2878 Cluster_637295 V1285617 S Virulence-associated protein D COG3309 Cluster_610880 V1285618 map02040 N Pfam:DUF1078 COG4786 Cluster_614550 V1285619 TRPB map00260,map00400,map01100,map01110,map01230 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) COG1350 Cluster_817192 V1285620 LGT M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 Cluster_657481 V1285621 S hi0933 family COG2081 Cluster_683596 V1285622 YAET M outer membrane protein assembly complex, YaeT protein COG4775 Cluster_610881 V1285623 S NA 0YH2T Cluster_610882 V1285627 AASI_0159 L transposase is116 is110 is902 family COG3547 Cluster_610883 V1285628 M teichoic acid biosynthesis COG1887 Cluster_702496 V1285630 S NA 0YA4G Cluster_793334 V1285632 FBP map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120 G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 COG3855 Cluster_715239 V1285634 DACB map00550 M d-alanyl-d-alanine carboxypeptidase COG2027 Cluster_705599 V1285635 map02010 P Nickel transport complex protein, NikM subunit, transmembrane 11GS3 Cluster_614554 V1285639 S NA 11H0J Cluster_777642 V1285640 EUTE map00010,map00071,map00350,map00362,map00620,map00621,map00622,map00625,map00626,map00650,map01100,map01110,map01120 C Dehydrogenase COG1012 Cluster_614555 V1285641 PFK map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01230 G K00850 6-phosphofructokinase 1 EC 2.7.1.11 COG0205 Cluster_614557 V1285644 YGCQ C electron transfer flavoprotein subunit ygcQ COG2025 Cluster_614559 V1285646 RECA map03440 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 Cluster_692453 V1285647 K, L domain protein COG0553 Cluster_614560 V1285648 O Peptidyl-prolyl cis-trans isomerase 0XT59 Cluster_614561 V1285649 S NA 0Y4TW Cluster_614562 V1285650 BL00689 K Transcriptional regulator, GntR family COG1802 Cluster_699466 V1285651 L Integrase 11F4A Cluster_721797 V1285654 THRS map00970 J threonyL-tRNA synthetase COG0441 Cluster_637296 V1285655 S NA 0ZK9J Cluster_614564 V1285657 TSF J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 Cluster_614565 V1285658 PPK map00190,map03018 P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) COG0855 Cluster_641286 V1285659 TRUA J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 Cluster_708673 V1285660 S radical SAM domain protein COG4277 Cluster_618277 V1285662 RPLC map03010 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 Cluster_614566 V1285663 PEPT E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 Cluster_614567 V1285664 RFBD map00521,map00523,map01100,map01110 M Dtdp-4-dehydrorhamnose reductase COG1091 Cluster_614568 V1285665 FADD map00071,map01100,map03320,map04146,map04920 I Amp-dependent synthetase and ligase COG0318 Cluster_614569 V1285667 S Bacterial protein of unknown function (DUF885) COG4805 Cluster_728468 V1285669 V ABC transporter COG1136 Cluster_797294 V1285674 MNAA map00520,map01100,map01110 M UDP-N-acetylglucosamine 2-epimerase COG0381 Cluster_614570 V1285675 VANW V VanW family COG2720 Cluster_614571 V1285678 NORV map05132 C uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center COG1773 Cluster_614572 V1285679 ATPD map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG1394 Cluster_614573 V1285680 PFLB map00620,map00640,map00650,map01100 C Formate acetyltransferase COG1882 Cluster_657482 V1285682 YLME F alanine racemase domain protein COG0325 Cluster_614574 V1285683 TRKA P Potassium uptake protein COG0569 Cluster_614575 V1285684 DPPA E Peptidase M55 D-aminopeptidase COG2362 Cluster_614576 V1285686 map00051 M Transferase COG1216 Cluster_809458 V1285688 YJGN S Membrane COG4269 Cluster_614578 V1285690 PROV map02010 E Glycine betaine COG4175 Cluster_614580 V1285696 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_699467 V1285697 PUUR K Transcriptional regulator COG1396 Cluster_614581 V1285698 S NA 0ZHU9 Cluster_614582 V1285701 PONA map00550,map01100 M penicillin-binding protein 1A COG5009 Cluster_614583 V1285702 P TonB-dependent Receptor Plug 0XNNV Cluster_900972 V1285703 TRMD map00900,map01100,map01110 J Specifically methylates guanosine-37 in various tRNAs (By similarity) COG0336 Cluster_670207 V1285707 RBFA J Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) COG0858 Cluster_614584 V1285708 TAGO M Glycosyl transferase, family 4 COG0472 Cluster_618278 V1285709 S NA 0XRT7 Cluster_844431 V1285711 S amidinotransferase COG4874 Cluster_848316 V1285712 ROCD map00330,map01100,map01110 E Aminotransferase COG4992 Cluster_618279 V1285713 VALS map00970 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 Cluster_836451 V1285714 YQHA L UPF0114 protein COG2862 Cluster_614585 V1285715 map00564,map00730 C fad dependent oxidoreductase COG0579 Cluster_618280 V1285717 S NA 11NX4 Cluster_614587 V1285718 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_614588 V1285720 S NA 0YCKF Cluster_755267 V1285721 S Sss sodium solute transporter superfamily COG4146 Cluster_614589 V1285722 FABB map00061,map00780,map01100 H synthase COG0304 Cluster_618281 V1285723 P Sodium/hydrogen exchanger family COG0025 Cluster_734983 V1285724 GREA K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) COG0782 Cluster_614590 V1285725 HYDE map00780,map01100 H radical SAM domain protein COG0502 Cluster_755268 V1285726 C Alcohol dehydrogenase zinc-binding domain protein COG1063 Cluster_614591 V1285727 METTU_1963 L Transposase 0XRAH Cluster_614593 V1285729 C 4Fe-4S ferredoxin, iron-sulfur binding COG1145 Cluster_614594 V1285731 HUTI map00340,map01100 Q imidazolone-5-propionate hydrolase COG1228 Cluster_785537 V1285732 RPSB map03010 J 30S ribosomal protein S2 COG0052 Cluster_657483 V1285733 TPIA map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01230 G Triose-phosphate isomerase COG0149 Cluster_614595 V1285742 S NA 101UU Cluster_618285 V1285743 CASA L crispr-associated protein 0XPA1 Cluster_718491 V1285744 NRDI F Probably involved in ribonucleotide reductase function (By similarity) COG1780 Cluster_618286 V1285745 GUAB map00230,map00983,map01100,map01110 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0517 Cluster_614596 V1285749 YHAM S UPF0597 protein COG3681 Cluster_614597 V1285750 P TonB-linked outer membrane protein, SusC RagA family 0XNNV Cluster_825053 V1285751 L site-specific recombinase, phage integrase family 0ZQ44 Cluster_621921 V1285752 GLDA map00561,map01100 C glycerol dehydrogenase COG0371 Cluster_741709 V1285753 PTCC map02060 G pts system COG1455 Cluster_618287 V1285755 S Domain of unknown function (DUF1788) 11KAX Cluster_828830 V1285756 S NA 0XQCC Cluster_741710 V1285757 ATPE map00190,map00195,map01100 C ATP synthase f0, c subunit 0ZXQ9 Cluster_614599 V1285761 L DNA primase 11GUV Cluster_718492 V1285764 BMUL_3442 map00310,map00780,map01100 E peptidase S10, serine carboxypeptidase COG2939 Cluster_748364 V1285766 CG1711 C Aldo keto reductase COG0667 Cluster_708674 V1285768 TATD L Hydrolase, tatD family COG0084 Cluster_618288 V1285770 EPMA map00970 J With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) COG2269 Cluster_721798 V1285771 map02020 T Histidine kinase 0XNMH Cluster_618289 V1285773 T phage Mu protein F like protein COG5585 Cluster_674592 V1285775 map00300,map01100,map01110,map01120,map01230 E, M Dihydrodipicolinate synthase COG0329 Cluster_618290 V1285776 BRNQ E branched-chain amino acid transport system II carrier protein COG1114 Cluster_621922 V1285777 PPIA O PPIases accelerate the folding of proteins (By similarity) COG0652 Cluster_621923 V1285778 RNFA C Electron transport complex COG4657 Cluster_645163 V1285779 S NA 11J85 Cluster_892495 V1285780 YJCD S Xanthine uracil vitamin C permease COG2252 Cluster_618291 V1285781 G Alpha-glucosidase 0XNZD Cluster_614601 V1285782 T Pasta domain containing protein COG2815 Cluster_614602 V1285783 M Efflux transporter RND family MFP subunit COG0845 Cluster_614603 V1285784 NIKC map02010 P Nickel transporter permease NikC COG1173 Cluster_614604 V1285785 PRKC T serine threonine protein kinase COG0515 Cluster_705600 V1285786 FBA2 map00010,map00030,map00051,map00052,map00680,map00710,map01100,map01110,map01120,map01230 G aldolase COG0191 Cluster_618292 V1285787 O peptidase, S8 COG1404 Cluster_708675 V1285789 S Inherit from NOG: Plasmid segregation actin-type ATPase ParM 0XQMS Cluster_618294 V1285792 TTDB map00020,map00630,map00720,map01100,map01110,map01120 C fumarate COG1838 Cluster_614605 V1285793 HASR P Receptor 16RPG@proNOG Cluster_618295 V1285794 FOLP map00790,map01100 H dihydropteroate synthase COG0294 Cluster_649272 V1285795 map02010 E ABC, transporter COG4166 Cluster_614606 V1285797 M Inherit from COG: Cell wall binding repeat 2-containing protein COG2247 Cluster_618297 V1285799 S NA 0YDFB Cluster_614607 V1285800 YDJK G transport protein 0ZVY1 Cluster_737231 V1028401 SP_0341 S UPF0371 protein COG4868 Cluster_765356 V1028402 XERD L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 Cluster_557045 V1028405 M mandelate racemase muconate lactonizing COG4948 Cluster_707799 V1028407 PIRIN O pirin domain protein COG1741 Cluster_557047 V1028408 WECC map00051,map00363,map00520,map00591,map00625,map00650,map01100,map01120 M Dehydrogenase COG0677 Cluster_673167 V1028409 NIXA P High-affinity COG3376 Cluster_557048 V1028410 P Heavy metal efflux pump, CzcA COG3696 Cluster_557049 V1028411 BMUL_5579 S Integrase 174YK@proNOG Cluster_557050 V1028413 S Ragb susd domain-containing protein 0XTE0 Cluster_557051 V1028414 PEPN map00480,map01100 E Peptidase M1 membrane alanine aminopeptidase COG0308 Cluster_557052 V1028415 S NA 183QW@proNOG Cluster_835309 V1028418 BMUL_2753 F ribonuclease COG4290 Cluster_784384 V1028420 S NA 18A2Q@proNOG Cluster_557055 V1028422 V (ABC) transporter 0XQRE Cluster_557056 V1028423 HSDR V type I restriction-modification system COG0610 Cluster_557057 V1028424 S NA 0XQBQ Cluster_624521 V1028425 ADA K AraC family transcriptional regulator COG2169 Cluster_557058 V1028428 BMUL_1335 S Protein of unknown function (DUF1800) COG5267 Cluster_660345 V1028429 LPD map00010,map00020,map00260,map00280,map00620,map01100,map01110,map01120 C dihydrolipoyl dehydrogenase COG1249 Cluster_557059 V1028430 DLTD map05150 M D-alanyl-lipoteichoic acid biosynthesis protein DltD COG3966 Cluster_647937 V1028434 YDFQ O Thioredoxin COG0526 Cluster_557061 V1028435 HSDR V Type I site-specific deoxyribonuclease COG0610 Cluster_776574 V1028436 YFDH map00510,map00520,map01100,map01110 M glycosyl transferase, family 2 COG0463 Cluster_816090 V1028438 BCSF M Cellulose biosynthesis protein BcsF 17KSJ@proNOG Cluster_757768 V1028440 PHHA map00360,map00380,map00400,map01100,map01230 E Phenylalanine 4-monooxygenase COG3186 Cluster_912276 V1028441 PHHB H Pterin carbinolamine dehydratase COG2154 Cluster_560090 V1028442 P solute-binding protein COG1840 Cluster_557062 V1028443 SHC P drug resistance transporter, EmrB QacA subfamily 0XNN3 Cluster_557063 V1028445 PRFA J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) COG0216 Cluster_812277 V1028447 OMPW M OmpW family COG3047 Cluster_557065 V1028449 ACD map00071,map00280,map00281,map00410,map00640,map00650,map01100,map01110,map03320 I Acyl-coa dehydrogenase COG1960 Cluster_557066 V1028451 S tail tape measure protein, TP901 family 0Y9J8 Cluster_557068 V1028453 BFRH P tonb-dependent siderophore receptor COG1629 Cluster_867096 V1028456 DUT map00240,map01100 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 Cluster_585240 V1028459 EGSA C Dehydrogenase COG0371 Cluster_727395 V1028464 RAMA K LuxR family transcriptional regulator COG2771 Cluster_875092 V1028467 C Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) COG4117 Cluster_750763 V1028468 S The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) COG2041 Cluster_557069 V1028469 EMRB P drug resistance transporter EmrB QacA 16PY9@proNOG Cluster_557070 V1028471 YCAO S UPF0142 protein ycaO COG1944 Cluster_598873 V1028472 S Membrane nuclease 1CAQN@tenNOG Cluster_808268 V1028474 LYS O glycoside hydrolase, family 19 COG3179 Cluster_879075 V1028475 S NA 1297W Cluster_560091 V1028476 FDNG map00630,map00680,map01100,map01120,map02020 C formate dehydrogenase alpha subunit COG0243 Cluster_572474 V1028477 REPW S Plasmid Encoded RepA Protein 16TFD@proNOG Cluster_560092 V1028478 DLD map00620,map00630,map01100,map01110,map01120 C FAD linked oxidase domain protein COG0277 Cluster_560093 V1028479 M Lytic transglycosylase catalytic COG0741 Cluster_560094 V1028481 GUTB map00051,map01100 C Dehydrogenase COG1063 Cluster_585241 V1028483 S integral membrane protein 0Y7KE Cluster_560096 V1028484 BMUL_6096 K AraC family transcriptional regulator COG4977 Cluster_754202 V1028485 S NA 17D2X@proNOG Cluster_560097 V1028489 IUNH map00230,map00760,map01100 F nucleoside hydrolase COG1957 Cluster_560098 V1028490 K lysr family transcriptional regulator 16S7X@proNOG Cluster_560099 V1028491 BMUR_1701 L DNA mismatch repair protein 0XQSW Cluster_560100 V1028493 YBDN S Phosphoadenosine phosphosulfate reductase COG3969 Cluster_560101 V1028494 RPLA map03010 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 Cluster_560102 V1028495 DNAE map00230,map00240,map01100,map03030,map03430,map03440 L DNA polymerase III subunit alpha COG0587 Cluster_867097 V1028498 FEMA map00550,map01100 V femAB family COG2348 Cluster_887194 V1028500 AZLC E amino acid COG1296 Cluster_747382 V1028501 RV0038 K UPF0301 protein COG1678 Cluster_560103 V1028502 ILVB map00290,map00650,map00660,map00770,map01100,map01110,map01210,map01230 E acetolactate synthase COG0028 Cluster_714276 V1028504 CYAA map00230,map05111 F Adenylate cyclase COG3072 Cluster_652034 V1028507 V Type III restriction enzyme, res subunit 0Y2F5 Cluster_560104 V1028508 DAPE map00300,map01100,map01120,map01230 E Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) COG0624 Cluster_560105 V1028510 SETB G sugar efflux transporter 16SGV@proNOG Cluster_562991 V1028511 CLPC2 O ATPase AAA-2 COG0542 Cluster_560106 V1028515 TOPB L Dna topoisomerase COG0550 Cluster_560107 V1028516 FHLA K Transcriptional COG3604 Cluster_560108 V1028517 AAP map05150 M surface protein 0XSC2 Cluster_560109 V1028519 RHUM S DNA-binding protein COG3943 Cluster_560110 V1028521 YHCD map05133 M usher protein( 16QS5@proNOG Cluster_730778 V1028522 S NA 16Q6F@proNOG Cluster_816095 V1028524 FLHD map02020,map02040 K Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) 17CAX@proNOG Cluster_891246 V1028525 FLHC map02020,map02040 K Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region 16TFE@proNOG Cluster_560111 V1028526 Q isochorismatase hydrolase COG1335 Cluster_747383 V1028528 RPSL map03010 J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) COG0048 Cluster_560113 V1028529 SUN J Fmu (Sun) domain-containing protein COG0144 Cluster_560114 V1028534 FEPC map02010 P ABC, transporter COG1120 Cluster_598874 V1028535 YPUA S secreted protein COG4086 Cluster_686587 V1028536 HIPB K transcriptional regulator 17THW@proNOG Cluster_730779 V1028539 G extracellular solute-binding protein family 1 173DQ@proNOG Cluster_560115 V1028541 S Filamentation induced by cAMP protein fic COG3177 Cluster_560116 V1028544 MTR map00010,map00020,map00260,map00280,map00480,map00620,map01100,map01110,map01120 C pyridine nucleotide-disulfide oxidoreductase COG1249 Cluster_727397 V1028548 map02010 E Inner-membrane translocator COG0559 Cluster_560117 V1028549 NARB map00630,map00680,map00910,map01100,map01120 C Molybdopterin oxidoreductase Fe4S4 domain COG0243 Cluster_714277 V1028550 S ABC superfamily, ATP binding cassette transporter COG4850 Cluster_792206 V1028553 MURB map00520,map00550,map01100 M Cell wall formation (By similarity) COG0812 Cluster_560118 V1028556 RECN L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 Cluster_560119 V1028557 YJJK S ABC transporter, ATP-binding protein COG0488 Cluster_560120 V1028558 BMUL_4883 map00363,map00650,map00960,map01120 Q esterase, PHB depolymerase COG3509 Cluster_772760 V1028559 PTCC map02060 G pts system COG1455 Cluster_707801 V1028560 M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) COG4623 Cluster_717526 V1028561 CRGA D septation inhibitor protein 121NJ Cluster_682203 V1028565 PTSI map00051,map01100,map02060 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) COG1080 Cluster_562995 V1028566 CUER K Transcriptional regulator COG0789 Cluster_677664 V1028567 MRPF P monovalent cation H antiporter subunit F COG2212 Cluster_799960 V1028570 PEPO map04614,map04640,map04974,map05010 O Endothelin-converting enzyme 1 COG3590 Cluster_870968 V1028574 S periplasmic secreted protein COG3477 Cluster_747384 V1028575 UBIG map00130,map01100,map01110 H Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) COG2227 Cluster_562996 V1028577 map00071,map01100,map03320,map04146,map04920 I amp-dependent synthetase and ligase COG0318 Cluster_870969 V1028579 S Toxic component of a toxin-antitoxin (TA) module. A COG1487 Cluster_602335 V1028581 PTPA T Low molecular weight phosphotyrosine protein phosphatase COG0394 Cluster_875093 V1028584 INO1 map00521,map00562,map01100,map01110 I synthase COG1260 Cluster_566179 V1028585 S nucleoside recognition domain protein COG3314 Cluster_562998 V1028586 CMTB S esterase COG0627 Cluster_562999 V1028587 CLPX map04112 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 Cluster_720818 V1028588 RPIC_1669 S NA 17HUD@proNOG Cluster_566180 V1028589 S NA 0ZHU9 Cluster_673168 V1028590 ELAA S acetyltransferase, (GNAT) family COG2153 Cluster_563000 V1028595 map02010 P ABC transporter COG1131 Cluster_652035 V1028597 map00564,map01100 I Phosphoesterase, PA-phosphatase related 17GGD@proNOG Cluster_618299 V1285803 S NA 11RAW Cluster_618300 V1285804 S NA 0YRUB Cluster_618301 V1285805 NSPC map00330 E Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine (By similarity) COG0019 Cluster_614610 V1285809 L helicase COG4646 Cluster_614611 V1285810 YQXD S UPF0178 protein COG1671 Cluster_614612 V1285812 PDAA G Delta-lactam-biosynthetic de-N-acetylase COG0726 Cluster_696197 V1285813 WCAM M colanic acid biosynthesis protein 174YR@proNOG Cluster_645165 V1285814 LYTR K TRANSCRIPTIONal COG1316 Cluster_614614 V1285816 L Resolvase COG1961 Cluster_618303 V1285817 L Helicase COG4581 Cluster_614615 V1285819 ILVE map00280,map00290,map00770,map01100,map01110,map01210,map01230 E brancheD-chain amino acid aminotransferase COG0115 Cluster_618304 V1285822 UUP S Abc transporter COG0488 Cluster_661686 V1285823 MRDB map04112 M Rod shape-determining protein rodA COG0772 Cluster_618305 V1285824 MDLA V ABC transporter, ATP-binding protein COG1132 Cluster_618306 V1285825 map03030,map04112 L Replicative dna helicase COG0305 Cluster_661687 V1285826 MRAY map00550,map01100 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) COG0472 Cluster_708676 V1285827 ATP2C1 P p-type ATPase COG0474 Cluster_618308 V1285829 GRPE O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 Cluster_770251 V1285830 S Filamentation induced by cAMP protein fic COG3177 Cluster_618309 V1285832 M extracellular nuclease 1AQ1S@spiNOG Cluster_618310 V1285833 YHAM S UPF0597 protein COG3681 Cluster_618311 V1285834 MANA map00051,map00520,map01100,map01110 G mannose-6-phosphate isomerase COG1482 Cluster_618312 V1285836 NRDA map00230,map00240,map01100 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 Cluster_645166 V1285838 PRFC J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) COG4108 Cluster_674593 V1285839 SPEA map00330,map01100 E Catalyzes the biosynthesis of agmatine from arginine (By similarity) COG1166 Cluster_821091 V1285841 BL00759 L Phage terminase, large subunit COG1783 Cluster_618314 V1285842 CCON map00190,map01100,map02020 C cytochrome C oxidase, cbb3-type, subunit i COG3278 Cluster_618315 V1285843 NUC L nuclease COG1525 Cluster_661688 V1285846 F Uracil permease COG2233 Cluster_618316 V1285847 RPOB map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 Cluster_705601 V1285849 YIEG S Xanthine uracil vitamin C permease COG2252 Cluster_621924 V1285850 CNHA S hydrolase COG0388 Cluster_618317 V1285851 DPPA E extracellular solute-binding protein, family 5 COG0747 Cluster_840390 V1285852 RES V Type III COG3587 Cluster_618319 V1285858 YLOV S dak2 domain fusion protein ylov COG1461 Cluster_618321 V1285860 TREY map00500,map01100,map01110 G malto-oligosyltrehalose synthase COG3280 Cluster_618322 V1285861 AMIA2 map02010 E Oligopeptide-binding protein COG4166 Cluster_618323 V1285862 G Inherit from COG: symporter activity COG2211 Cluster_618324 V1285863 CSTA T Carbon starvation protein CstA COG1966 Cluster_618325 V1285866 V Efflux ABC transporter, permease protein COG0577 Cluster_618326 V1285867 map00051,map00363,map00591,map00625,map00650,map01100,map01120 E Alcohol dehydrogenase GroES-like domain COG1063 Cluster_618327 V1285868 SP_0239 S UPF0210 protein COG2848 Cluster_618328 V1285869 YDIA S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) COG1806 Cluster_741711 V1285871 PACL P calcium-translocating P-type ATPase COG0474 Cluster_618330 V1285872 MIAA map00908,map01100,map01110 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 Cluster_751798 V1285873 ENGB S Necessary for normal cell division and for the maintenance of normal septation (By similarity) COG0218 Cluster_725147 V1285874 PUNA map00230,map00240,map00760,map01100,map01110 F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) COG0005 Cluster_618331 V1285875 map00010,map00030,map00051,map00052,map00680,map00710,map01100,map01110,map01120,map01230 G aldolase COG0191 Cluster_618332 V1285876 YRXA K 3H domain protein COG1827 Cluster_618334 V1285878 map02010 V ABC transporter 0XPIZ Cluster_618335 V1285879 N Cell surface protein 0XQ7Y Cluster_618336 V1285883 S NA 108K1 Cluster_618337 V1285885 SCLAV_2918 S integral membrane protein 11X32 Cluster_721799 V1285886 G Binding-protein-dependent transport system inner membrane component COG3833 Cluster_618339 V1285889 LYSS map00970 J lysyL-tRNA synthetase COG1190 Cluster_702497 V1285894 SCPB K Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) COG1386 Cluster_805446 V1285895 S NA 11RYV Cluster_618341 V1285896 METQ map02010 P (LipO)protein COG1464 Cluster_618343 V1285899 map00230 S phosphorylase 11F11 Cluster_618344 V1285901 L Inherit from COG: DNA Methylase COG0827 Cluster_718493 V1285902 P TonB-dependent receptor 1AI9D@sphNOG Cluster_618345 V1285903 S NA 108DP Cluster_741712 V1285904 P TonB dependent receptor 0XNNV Cluster_618346 V1285905 ARGG map00250,map00330,map01100,map01110,map01230 E Citrulline--aspartate ligase COG0137 Cluster_618347 V1285906 CBC4_0930 L Transposase COG3666 Cluster_618348 V1285907 ACNB map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01210,map01230 C Aconitate hydratase 2 COG1049 Cluster_621926 V1285908 GLTD C oxidoreductase FAD NAD(P)-binding domain protein COG0543 Cluster_688029 V1285909 S transporter 0Z6QR Cluster_621927 V1285911 CSAC_1405 S NA 0Y46N Cluster_618349 V1285912 YQEV J MiaB-like tRNA modifying enzyme COG0621 Cluster_621928 V1285913 PBP1B map00310,map00550,map00780,map01100 M penicillin-binding protein COG0744 Cluster_817195 V1285916 NTPG map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG1436 Cluster_618350 V1285917 IRP P tonB-dependent Receptor COG1629 Cluster_618351 V1285918 UPPS map00900,map01110 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 Cluster_618352 V1285919 PCP O Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) COG2039 Cluster_618353 V1285920 S had-superfamily hydrolase, subfamily ia, variant COG1011 Cluster_618355 V1285922 MENB map00130,map00360,map01100,map01110,map01120 H Naphthoate synthase COG0447 Cluster_621929 V1285923 AROK map00400,map01100,map01110,map01230 E Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) COG0703 Cluster_679031 V1285924 P oligopeptide transport system, permease COG1173 Cluster_725148 V1285925 P transporter COG0733 Cluster_621930 V1285926 map00190,map00680,map01100 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity) COG1156 Cluster_828831 V1285929 RBSC map02010,map02030 G abc transporter COG1172 Cluster_621931 V1285930 O ADP-ribosylglycohydrolase COG1397 Cluster_618356 V1285931 RHAT7 E, G Transporter COG0697 Cluster_725149 V1285932 DGT map00230 F deoxyguanosinetriphosphate triphosphohydrolase-like protein COG0232 Cluster_618357 V1285933 LNT M Transfers the fatty acyl group on membrane lipoproteins (By similarity) COG0815 Cluster_618358 V1285934 S Pfam:Phage_integr_N 0Y9YC Cluster_828832 V1285935 BGLF map00010,map00500,map00520,map02060 G pts system COG2190 Cluster_892497 V1285936 RPIB map00030,map00052,map00710,map01100,map01110,map01120,map01230 G Ribose/Galactose Isomerase COG0698 Cluster_618359 V1285937 VANZ V VanZ-like protein COG4767 Cluster_618360 V1285939 map02010 G solute-binding protein 0XR78 Cluster_621932 V1285940 COMEA L Competence protein COG1555 Cluster_618361 V1285942 DESOR_0674 L Integrase catalytic subunit COG4584 Cluster_621933 V1285943 USHA map00230,map00240,map00760,map01100,map01110 F 5'-nucleotidase COG0737 Cluster_621934 V1285944 RPOC map00230,map00240,map01100,map03020 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 Cluster_728471 V1285946 FLUTA_0256 L Transposase COG3464 Cluster_621935 V1285948 S peptidase 0XPBV Cluster_621936 V1285949 NADD map00230,map00760,map01100,map05340 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) COG1057 Cluster_621937 V1285950 MTAD F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) COG0402 Cluster_618363 V1285951 L Inherit from COG: DNA Methylase COG0827 Cluster_625706 V1285953 map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120 G ROK family COG1940 Cluster_618364 V1285954 S domain protein 0XPXI Cluster_618365 V1285955 C Aldo keto reductase COG1453 Cluster_621938 V1285958 PBUG S Xanthine uracil vitamin C permease COG2252 Cluster_621940 V1285962 PDXS map00750 H Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) COG0214 Cluster_755269 V1285964 DMPA E, Q peptidase s58 dmpa COG3191 Cluster_929204 V1285965 S TIM-barrel fold 11FGY Cluster_621941 V1285967 UVRB map03420 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 Cluster_621942 V1285968 BIOD map00780,map01100 H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) COG0132 Cluster_625707 V1285969 S NA 0XRT7 Cluster_618367 V1285970 METTU_1963 L Transposase 0XRAH Cluster_670208 V1285971 MOTA map02020,map02030,map02040 N MotA TolQ exbB proton channel COG1291 Cluster_738312 V1285972 GLPF G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) COG0580 Cluster_621943 V1285974 RIMO J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) COG0621 Cluster_618369 V1285976 TRPB map00260,map00400,map01100,map01110,map01230 E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) COG1350 Cluster_621944 V1285977 map00052 S Beta-galactosidase I 0ZVJH Cluster_621946 V1285980 PSHM map03070 U General secretion pathway COG3149 Cluster_621947 V1285981 S Bacterial membrane protein 0XT2P Cluster_670209 V1285982 YACL S PilT protein domain protein COG4956 Cluster_621949 V1285985 MTAD F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) COG0402 Cluster_618372 V1285986 PSTA map02010 P Phosphate ABC transporter COG0581 Cluster_618373 V1285987 S Nitroreductase 11NZA Cluster_645168 V1285989 P Na Pi-cotransporter COG1283 Cluster_621951 V1285991 PPP map03070 T phosphatase COG0631 Cluster_621952 V1285992 MFD map03420 L transcriptioN-repair coupling factor COG1197 Cluster_621953 V1285993 PURT map00230,map00670,map01100,map01110 F Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR COG0027 Cluster_621954 V1285994 WS0013 S membrAne 0XPGN Cluster_618374 V1285995 S Chromosome segregation ATPase 11HKQ Cluster_777643 V1285996 GALK map00052,map00520,map01100,map01110 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) COG0153 Cluster_621955 V1285998 YICL E, G Transporter COG0697 Cluster_618375 V1285999 PITRM1 O peptidase COG1026 Cluster_797297 V1286000 RPSQ map03010 J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal COG0186 Cluster_621956 V1286002 FRDA map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120,map02020,map05134 C Succinate dehydrogenase (Flavoprotein subunit) COG1053 Cluster_828833 V1286004 ATPA map00190,map00195,map01100,map04610,map05202 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 Cluster_848317 V1286005 ATPH map00190,map00195,map01100 C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) 11XG8 Cluster_621957 V1286006 GYRA L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 Cluster_629416 V1286008 SDHC map00020,map00190,map00623,map00650,map00720,map01100,map01110,map01120 C succinate dehydrogenase 11IIM Cluster_621958 V1286009 RPLF map03010 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 Cluster_832632 V1286014 map02010 P ABC transporter COG1122 Cluster_618377 V1286015 map00300,map00550,map01100 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) COG0770 Cluster_896635 V1286016 S NA 0ZHU9 Cluster_621959 V1286020 T Two component regulator three Y motif family 1DJAD@verNOG Cluster_625708 V1286021 S caax amino terminal protease family protein COG1266 Cluster_621960 V1286022 ISPD map00900,map01100,map01110 I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) COG1211 Cluster_855885 V1286023 GLTD map00450 E Selenate reductase, YgfK COG0493 Cluster_699468 V1286025 S Membrane 0XRRH Cluster_809459 V1286026 S Inherit from COG: ATPase (AAA COG1373 Cluster_696198 V1286027 E ACT domain protein COG4747 Cluster_621961 V1286028 S domain M protein repeat protein 0XPG7 Cluster_621962 V1286029 S YbbR-like protein COG4856 Cluster_621963 V1286031 NADE map00760,map01100 H Nad synthetase COG0388 Cluster_621964 V1286032 RHO map03018 K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) COG1158 Cluster_621965 V1286033 H Sodium pantothenate symporter COG4145 Cluster_805447 V1286034 GLNQ E (ABC) transporter COG1126 Cluster_621966 V1286036 K Transcriptional regulator 0XWJY Cluster_745019 V1286037 GLNN map00250,map00330,map00630,map00910,map01100,map01120,map01230,map02020,map04724,map04727 E glutamine synthetase COG3968 Cluster_679032 V1286038 Q PKS_KR COG3321 Cluster_621967 V1286039 ACEE map00010,map00020,map00620,map00650,map01100,map01110,map01120 C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) COG2609 Cluster_621968 V1286040 ENGCP S cell wall surface anchor family protein 0XRFZ Cluster_621969 V1286044 YEAZ O Peptidase M22 Glycoprotease COG1214 Cluster_925804 V1286045 map00190,map00680,map01100 C ATP synthase, subunit F 124BE Cluster_805448 V1286046 map00190,map00680,map01100 C ATP synthase subunit C 11URT Cluster_705602 V1286047 ILES map00970 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 Cluster_932434 V1286049 S NA 0XS0Q Cluster_859952 V1286050 PYCB map00330,map00620,map01100 C Oxaloacetate decarboxylase COG5016 Cluster_836452 V1286052 AGAF map00052,map02060 G pts system COG2893 Cluster_621971 V1286053 S NA 11Q1R Cluster_789535 V1286055 S NA 0ZHU9 Cluster_645169 V1286056 SP_1328 E sodium solute COG0591 Cluster_621972 V1286057 S domain protein 0XPXI Cluster_621973 V1286058 S tape measure 11PSY Cluster_621974 V1286059 S mobilization protein 0XWI1 Cluster_621975 V1286060 RBSK map00030 G ribokinase COG0524 Cluster_649273 V1286061 MUTT L hydrolase COG0494 Cluster_621976 V1286064 HPRA map00260,map00630,map00680,map01100,map01110,map01120 C D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain COG1052 Cluster_621977 V1286065 SBM map00280,map00630,map00640,map00720,map01100,map01120 I Methylmalonyl-coA mutase COG2185 Cluster_621978 V1286066 PHET map00970 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 Cluster_621979 V1286067 S NA 0Y8K6 Cluster_621980 V1286069 ALR map00473,map01100 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 Cluster_621982 V1286071 YIDC map03060,map03070 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins COG0706 Cluster_621983 V1286073 K transcriptional regulator, lysr family COG0583 Cluster_621984 V1286074 RLMD map00340,map00350,map00624,map01120 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 Cluster_785540 V1286075 P transport protein COG2985 Cluster_758781 V1286076 YJJI S glycine radical enzyme YjjI family 0XNMQ Cluster_801276 V1286077 YQFA S UPF0365 protein COG4864 Cluster_751799 V1286080 CLVE map02010 S NA 11PT3 Cluster_633234 V1286081 RNJB map03018 O Metallo-Beta-Lactamase COG0595 Cluster_621985 V1286082 RSME S Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) COG1385 Cluster_621986 V1286083 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_880346 V1286084 S NA 0Z6FE Cluster_621987 V1286085 UGD map00040,map00053,map00500,map00520,map01100,map01110 M UDP-glucose 6-dehydrogenase COG1004 Cluster_621988 V1286086 map00780,map01100 H biotin acetyl-CoA-carboxylase ligase COG0340 Cluster_621989 V1286087 S ABC transporter COG3845 Cluster_692454 V1286088 NANH map00511,map00600,map04142 G BNR Asp-box repeat protein COG4409 Cluster_625709 V1286091 LYSA map00300,map01100,map01110,map01120,map01230 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) COG0019 Cluster_621990 V1286093 TOPB L Dna topoisomerase COG0550 Cluster_621991 V1286094 J Glutamine amidotransferase COG2071 Cluster_793335 V1286095 YQFA S UPF0365 protein COG4864 Cluster_621992 V1286097 SIGB K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG1191 Cluster_932435 V1286098 S NA 128GQ Cluster_621993 V1286100 S NA 12B7K Cluster_711869 V1286102 YFCC S c4-dicarboxylate anaerobic carrier COG1288 Cluster_645170 V1286103 LEUS map00970 J Leucyl-tRNA synthetase COG0495 Cluster_645171 V1286104 YGFG map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120 I enoyl-CoA hydratase isomerase COG1024 Cluster_625710 V1286105 FHS map00670,map00720,map01100,map01120 F formyltetrahydrofolate synthetase COG2759 Cluster_621994 V1286106 YBHM S conserved inner membrane protein COG0670 Cluster_621996 V1286108 V type III restriction enzyme 0ZVQ5 Cluster_625711 V1286109 ECFA2 map02010 P ABC transporter, ATP-binding protein COG1122 Cluster_621997 V1286110 S fad dependent oxidoreductase COG2509 Cluster_625712 V1286112 ATPI map00190,map00680,map01100 C v-type atpase COG1269 Cluster_621998 V1286114 PYRB map00240,map00250,map01100 F aspartate transcarbamylase COG0540 Cluster_625713 V1286115 SOJ D Chromosome Partitioning Protein COG1192 Cluster_625714 V1286116 PEPD E Dipeptidase COG4690 Cluster_868194 V1286120 ILVA map00260,map00290,map01100,map01110,map01230 E Threonine dehydratase COG1171 Cluster_621999 V1286124 S NA 0YXMU Cluster_622000 V1286125 T transcriptional regulator COG2207 Cluster_622001 V1286128 YGIK G DctM-like transporters COG1593 Cluster_622002 V1286129 SELD map00450,map01100 E Synthesizes