Gene category Annotation COGID V1684181 S Transposase 11N3I V1872750 L Transposase COG3328 V1684119 L Transposase COG3328 V1885045 L transposase IS116 IS110 IS902 family protein COG3547 V1684135 L Transposase COG3328 V1806640 S Inherit from COG: Tail protein COG5283 V1302572 S NA 0ZHU9 V1149298 L transposase (IS4 family) protein 0XQ88 V1872749 L Transposase COG3328 V1032538 S Inherit from COG: Tail protein COG5283 V1684088 L Transposase COG3328 V1162988 L Inherit from COG: transposase COG2826 V1032205 L Transposase 11J2V V1199427 L transposase (IS4 family) protein 0XQ88 V1032679 L transcriptioN-repair coupling factor COG1197 V1002229 L Transposase (IS4 family 11HCS V1033443 L DNA helicase COG1112 V1032233 L Transposase COG2801 V1032606 V abc transporter permease protein COG0577 V1806613 L type iii restriction protein res subunit COG3886 V1891377 C (Ubiquinol oxidase) subunit I COG1271 V1684188 L Pfam:Transposase_8 COG2963 V1032310 L that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) COG0249 V1684136 V ATP-binding protein COG2274 V1032903 D Required for chromosome condensation and partitioning (By similarity) COG1196 V1033202 L helicase COG0847 V1047211 L SNF2 family COG0553 V1032665 L helicase COG3973 V1034189 G glycoside hydrolase family protein COG0383 V1796904 E Aminopeptidase COG0308 V1204467 L Inherit from COG: transposase COG2826 V1808158 L Inherit from COG: transposase COG2826 V1032357 S MMPL domain protein COG2409 V1032803 D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) COG0445 V1032966 G glycoside hydrolase family protein COG0383 V1047171 L Transposase COG3666 V1032705 L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination COG3857 V1033097 F carbamoyl-phosphate synthetase ammonia chain COG0458 V1150431 V type I restriction enzyme EcoKI subunit R COG4096 V1819407 L transposase (IS4 family) protein 0XQ88 V1033479 L transposase IS116 IS110 IS902 family protein COG3547 V1143254 M Phage minor structural protein COG4926 V1032767 P magnesium-translocating p-type atpase COG0474 V1047198 F carbamoyl-phosphate synthetase ammonia chain COG0458 V1032381 C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) COG2352 V1032782 S domain protein COG4717 V1033117 G Phosphoketolase COG3957 V1033132 M penicillin-binding protein COG0768 V1143422 L Inherit from COG: transposase COG2826 V1162583 S Transglycosylase SLT domain COG5283 V1884884 P magnesium-translocating p-type atpase COG0474 V1032664 L Transposase COG3666 V1150470 K TRANSCRIPTIONal COG3711 V1032318 L muts2 protein COG1193 V1033009 G Alpha-glucosidase COG1501 V1033012 T Histidine kinase COG2972 V1047007 J Glycyl-tRNA synthetase beta subunit COG0751 V1047039 U Pfam:TraG COG3505 V1885079 E Extracellular solute-binding protein, family 5 COG4166 V1033042 P cation-transporting atpase COG0474 V1033189 S Membrane COG4485 V1047236 O ATP-dependent clp protease, ATP-binding subunit COG0542 V1204502 F (Anaerobic) ribonucleoside-triphosphate reductase COG1328 V1872766 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0209 V1032215 L Transposase 1012J V1032324 P calcium-transporting ATPase COG0474 V1032412 E Dipeptidase COG4690 V1032470 V ABC transporter COG1132 V1032489 T Tetracycline resistance protein COG0480 V1032914 L dna polymerase I COG0749 V1032982 S Membrane 0Y3RG V1033078 L DNA polymerase III (alpha subunit) COG0587 V1033347 M phosphoglycerol transferase alkaline phosphatase superfamily protein COG1368 V1047286 S NA 11HZH V1143175 M phage tail tape measure protein COG5283 V1388962 L DNA topoisomerase IV, subunit A COG0188 V1884525 G oxidoreductase COG0673 V1890890 P cation-transporting atpase COG0474 V1032641 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 V1033276 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 V1035706 S NA 0ZHU9 V1143197 M polysaccharide biosynthesis protein COG2244 V1034201 V ATP-binding protein COG2274 V1047038 S NA 12A0K V1101503 P (P-type) ATPase COG0474 V1237103 G pts system COG2190 V1552696 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 V1552837 L transposase IS116 IS110 IS902 family protein COG3547 V1032206 O Endothelin-converting enzyme 1 COG3590 V1032638 J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 V1032880 L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 V1033165 S Plasmid pRiA4b ORF-3 family protein 1026Y V1033466 E Extracellular solute-binding protein, family 5 COG4166 V1047005 L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation COG1074 V1047070 M penicillin-binding protein COG0768 V1552755 M Sulfatase COG1368 V1884499 P ABC transporter, ATP-binding protein COG1122 V1032299 L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) COG0272 V1032589 V ABC transporter COG1132 V1032629 G hydrolase family 65, central catalytic COG1554 V1032802 S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 V1032845 E Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) 0XPUZ V1032990 V ABC transporter COG1132 V1033055 S ABC transporter COG3845 V1033346 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 V1101485 V ABC transporter COG1132 V1237091 L Transposase COG2801 V1684154 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 V1684155 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 V1684172 V ABC transporter COG1132 V1880844 V ABC transporter COG1132 V1883389 L Transposase COG2801 V1032434 J phenylalanyl-tRNA synthetase (beta subunit) COG0073 V1032628 G alpha amylase, catalytic region COG0366 V1032856 L Integrase 0ZS5X V1033256 L Helicase, RecD TraA family COG0507 V1034247 E decarboxylase COG1982 V1143339 L phage plasmid primase, p4 family COG4983 V1150387 T Histidine kinase COG0642 V1162595 P Cation-transporting atpase COG0474 V1755572 T Histidine kinase 0XNMH V1032391 D cell division protein FtsK COG1674 V1032740 V ABC, transporter COG4988 V1032792 M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) COG0449 V1032804 G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) COG0362 V1033170 I Hydroxymethylglutaryl-CoA synthase COG3425 V1033361 L atp-dependent rna helicase COG0513 V1033398 G levansucrase EC 2.4.1.10 0XR0E V1033562 P ABC transporter, ATP-binding protein COG1122 V1034270 L Transposase 1012J V1047201 G symporter COG2211 V1450945 L Transposase COG3666 V1755600 L Transposase COG3328 V1884555 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 V1891261 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0086 V1032746 V ABC transporter COG1132 V1032888 S Competence protein COG2333 V1032939 P Na H antiporter COG0569 V1033086 E Extracellular solute-binding protein, family 5 COG4166 V1033192 S Phi ETA orf 55-like protein 0YKVY V1033243 S (ABC) transporter COG0488 V1033247 S ABC transporter, ATP-binding protein COG0488 V1033290 P p-type ATPase COG2217 V1033563 F adenine deaminase COG1001 V1047017 T Diguanylate cyclase 0XNMH V1047181 G ABC transporter COG1653 V1204306 P phosphate abc transporter COG0573 V1684170 L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) COG0593 V1755585 L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 V1796834 L ATP-dependent DNA helicase pcra COG0210 V1883309 H, I Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) COG1154 V1883391 S ATPase (AAA COG1373 V1886306 O ATP-dependent Clp protease ATP-binding subunit COG0542 V1032201 Q Multicopper oxidase COG2132 V1032351 J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) COG0172 V1032486 E amino acid COG0531 V1032609 E amino acid COG1113 V1032652 O serine protease COG0265 V1033069 J cysteinyl-tRNA synthetase COG0215 V1033161 G beta-galactosidase COG3250 V1033273 G beta-galactosidase COG1874 V1034244 O Metallo-Beta-Lactamase COG0595 V1047157 V ABC transporter ATP-binding COG1132 V1047206 G pts system COG2190 V1101378 S NA 114KY V1101416 E ABC, transporter COG4166 V1204490 K TRANSCRIPTIONal COG3711 V1237086 G Major Facilitator COG0477 V1608693 E Aminotransferase COG0436 V1828770 G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) COG0574 V1872764 S ATPase (AAA COG1373 V1032212 E asparagine synthetase COG0367 V1032402 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 V1032452 S NA 0XPRZ V1032747 O Endothelin-converting enzyme 1 COG3590 V1032771 U hydrolase, family 8 0Y1JM V1032882 L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) COG0592 V1033340 L ATP-dependent DNA helicase recG COG1200 V1033595 M penicillin-binding protein COG0744 V1034256 L DNA topoisomerase IV (Subunit B) COG0187 V1047213 M Sulfatase COG1368 V1101466 V Type II restriction modification enzyme methyltransferase COG0286 V1143193 M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) COG0481 V1163624 O ATP-dependent CLP protease ATP-binding subunit COG0542 V1163762 G glucose-6-phosphate 1-dehydrogenase COG0364 V1202272 L Transposase (IS4 family 11HCS V1204768 L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) COG0323 V1755541 L Transposase (IS4 family 11HCS V1755579 K 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) COG0557 V1884278 G Glycogen debranching enzyme COG1523 V1884508 L Terminase, large subunit COG4626 V1032291 M group 1 glycosyl transferase COG0438 V1032476 C Glycolate oxidase subunit COG0277 V1032779 M penicillin-binding protein COG0744 V1032997 L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) COG0551 V1033033 J aspartyl-trna synthetase COG0173 V1033187 S NA 0Y3BQ V1033324 J Leucyl-tRNA synthetase COG0495 V1033369 S ErfK YbiS YcfS YnhG COG1376 V1033494 V ABC transporter, permease COG0577 V1033695 S Membrane COG1808 V1034221 G Phosphoglucomutase phosphomannomutase alpha beta alpha domain COG1109 V1322982 V ABC transporter COG1132 V1598290 S Rib/alpha-like repeat 10008 V1806665 L transposase IS116 IS110 IS902 family protein COG3547 V1032224 G GlcNAc 6-P deacetylase COG1820 V1032296 M polysaccharide biosynthesis protein COG2244 V1032407 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) COG1207 V1032415 F Catalyzes the synthesis of GMP from XMP (By similarity) COG0519 V1032588 V ABC transporter COG1132 V1033003 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) COG1080 V1033265 S Membrane COG0628 V1033413 F Plays an important role in the de novo pathway of purine nucleotide biosynthesis COG0104 V1033484 E sodium solute COG0591 V1033596 S Membrane 11WHS V1034291 L Adenine-specific COG0827 V1047008 M polysaccharide biosynthesis protein COG2244 V1149114 E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COG3842 V1199359 G pts system 124SH V1684175 M Membrane bOund o-acyl transferase mboat family protein COG1696 V1806592 S Lanthionine synthetase C family protein 11IVF V1828763 V ABC transporter COG1132 V1828795 C L-lactate COG1620 V1828860 S Lpxtg-motif cell wall anchor domain protein 0Y34J V1032374 H Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) COG1020 V1032473 M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) COG0769 V1032577 V (ABC) transporter COG2274 V1032699 E aminopeptidase c COG3579 V1032841 V ABC transporter COG1132 V1032971 L Integrase COG0582 V1033262 E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) COG0019 V1033268 M Glycosyl transferase COG0438 V1033406 S (ABC) transporter COG0488 V1033645 G Major Facilitator 12APV V1034281 E Inner membrane transporter yjeM 174IZ@proNOG V1047061 J threonyL-tRNA synthetase COG0441 V1047075 S surface protein 11NE4 V1143382 G Major Facilitator 0ZXAG V1163652 O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 V1204519 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 V1552781 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 V1684147 T sensor protein 0XNMH V1884240 P Transport of potassium into the cell (By similarity) COG3158 V1885137 E aminopeptidase c COG3579 V1032307 G pts system COG2190 V1032315 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 V1032344 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) COG0056 V1032491 P transporter COG0598 V1032745 V ABC transporter transmembrane region COG1132 V1033036 S ribosome biogenesis GTPase YqeH COG1161 V1033085 V ABC transporter, permease COG0577 V1033325 M Polysaccharide Biosynthesis Protein COG2244 V1034187 L Primosomal protein n' COG1198 V1034218 E Dipeptidase COG4690 V1034223 S (ABC) transporter COG0488 V1034239 S Myosin-Cross-Reactive Antigen COG4716 V1047113 T serine threonine protein kinase COG2815 V1047208 J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 V1143204 M Glycosyl transferase, family 2 0ZVME V1143661 S Endoribonuclease that initiates mRNA decay (By similarity) COG1418 V1204503 S Conserved Protein COG3538 V1684077 D This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) COG0849 V1684150 L Integrase COG0582 V1684156 J lysyL-tRNA synthetase COG1190 V1796843 G Phosphoketolase COG3957 V1819373 C Dehydrogenase COG1454 V1828822 S Myosin-Cross-Reactive Antigen COG4716 V1882362 T domain protein COG3887 V1032292 H Nicotinate phosphoribosyltransferase COG1488 V1032301 J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) COG0154 V1032410 F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) COG0504 V1032529 S ABC transporter, ATP-binding protein COG0488 V1032563 C phosphoenolpyruvate carboxykinase 0XT66 V1032581 G ABC transporter COG1653 V1032631 G (ABC) transporter COG2182 V1032632 P permease protein COG1175 V1032728 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) COG0770 V1032922 F 5'-nucleotidase COG0737 V1033180 G Sucrose phosphorylase COG0366 V1033275 G UDP-glucose-hexose-1-phosphate uridylyltransferase COG4468 V1033629 O Acts as a chaperone (By similarity) COG0443 V1033688 S surface protein 11NE4 V1034229 G alpha-galactosidase COG3345 V1034275 E amino acid COG0531 V1034282 G PTS System COG1264 V1034296 E acetolactate synthase COG0028 V1047240 G PTS system sugar-specific permease component COG3037 V1143205 M Glycosyl transferase (Group 1 COG0438 V1162587 V Abortive infection bacteriophage resistance protein COG4823 V1237119 L transposase COG0675 V1828818 C Formyl-CoA transferase COG1804 V1882246 P Chloride channel 103Y5 V1883097 G phosphohexose isomerase COG0166 V1884599 E amino acid COG0531 V1884712 F Phosphoribosylglycinamide synthetase COG0151 V1890912 E Dipeptidase COG4690 V1032207 G Major Facilitator 0ZVV9 V1032343 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) COG0224 V1032565 L DEAD DEAH box helicase COG1201 V1032567 P ammonium transporter 0XNMH V1032692 K TRANSCRIPTIONal COG1316 V1032730 E amino acid COG0531 V1032883 D cell division protein COG0772 V1032919 E peptidase M24 COG0006 V1033030 K, T In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) COG0317 V1033113 S NA 11UKT V1033455 M Glycosyl transferase family 8 0Y03U V1033716 E amino acid COG0531 V1047009 K Transcriptional regulator 0Y1S3 V1143201 M Polysaccharide biosynthesis protein COG3774 V1143256 S phage major capsid protein, HK97 family 0XTEI V1203328 L Integrase COG0582 V1806647 L DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) COG0358 V1806654 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 V1828804 C glycerophosphoryl diester phosphodiesterase COG4781 V1880059 L transposase COG2826 V1884693 L Topoisomerase COG0550 V1032231 E amino acid ABC transporter COG0834 V1032309 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 V1032375 S NA 11V0R V1032393 O peptidase, M16 COG0612 V1032517 L dna polymerase iii COG2812 V1032595 P Transport of potassium into the cell (By similarity) COG3158 V1032601 G PTS System COG1264 V1032667 S NA 0Y2NV V1032674 T Histidine kinase 0XNMH V1032676 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) COG0037 V1032703 E (ABC) transporter COG4608 V1032731 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) COG0112 V1032739 V (ABC) transporter COG4987 V1032849 S Protein of unknown function (DUF2974) 0XSVF V1032910 L replication initiation and membrane attachment protein COG3611 V1032916 S NlpC/P60 family COG5263 V1033130 M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) COG0771 V1033313 S NA 101GK V1033414 F adenylosuccinate lyase COG0015 V1033432 S Phage-associated protein, HI1409 family COG3567 V1033486 M Glycosyl transferase, family 2 COG1215 V1033516 S Xanthine uracil vitamin C permease COG2252 V1033520 M carboxypeptidase COG1686 V1033554 S Outer surface protein COG3589 V1033613 S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) COG2262 V1033632 H 1,4-dihydroxy-2-naphthoate octaprenyltransferase COG1575 V1034238 G Phosphoketolase COG3957 V1047002 S Membrane COG1434 V1047165 S NA 11NI8 V1101200 S TPR repeat-containing protein COG0457 V1269254 S NA 0ZHU9 V1336052 S NA 128JG V1338860 J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) COG0442 V1552702 V Beta-lactamase COG1680 V1614186 L Transposase COG3328 V1796862 K Transcriptional regulator 0Y1S3 V1806608 S ABC transporter (Permease COG4603 V1806610 P Chloride channel COG0038 V1819361 L Integrase catalytic subunit 0XPD4 V1882933 L transposase (IS4 family) protein 0XQ88 V1884609 S esterase COG0627 V1887002 L crispr-associated protein COG3513 V1887307 O Metallo-Beta-Lactamase COG0595 V1891109 C fumarate reductase flavoprotein, subunit COG1053 V1032203 P Lipoprotein COG1464 V1032350 S NA 120ST V1032372 M D-alanyl-lipoteichoic acid biosynthesis protein DltD COG3966 V1032380 V Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) COG1136 V1032418 T Histidine kinase COG2972 V1032472 T Histidine kinase COG0642 V1032625 K transcriptional regulator COG1609 V1032707 I Phosphomevalonate kinase COG1577 V1032756 S phage major capsid protein, HK97 family 0XTEI V1032881 L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) COG1195 V1033020 J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) COG4108 V1033045 G glycoside hydrolase family 4 COG1486 V1033164 S Abortive infection protein AbiGII 0XQHH V1033257 I Acyl-transferase COG1835 V1033261 S Lpxtg-motif cell wall anchor domain protein 0Y44U V1033274 G Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) COG0153 V1033549 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 V1033557 G Glyceraldehyde-3-phosphate dehydrogenase COG0057 V1033558 G Phosphoglycerate kinase COG0126 V1033682 S L-ascorbate 6-phosphate lactonase COG2220 V1033745 E amino acid COG0531 V1034198 G ABC transporter, ATP-binding protein COG3839 V1034300 G Phosphotransferase system, EIIC COG1455 V1046988 O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) COG0484 V1047216 V ABC transporter COG1132 V1198928 S NA 0ZHU9 V1338889 T gtp-binding protein typa COG1217 V1684085 E amino acid COG0531 V1684141 V Abi-like protein COG4823 V1684176 G pts system 124SH V1755599 C, P ABC transporter, permease COG1668 V1796915 G pullulanase, type i COG1523 V1796917 K HTH_ARAC COG2207 V1796925 G Gluconate kinase COG1070 V1806658 K Transcriptional regulator COG1737 V1819379 K Transcriptional regulator COG1396 V1828831 C uridylyltransferase COG1085 V1882399 C sagb-type dehydrogenase domain protein COG0778 V1884806 G domain protein COG1501 V1884880 L Pfam:Transposase_8 COG2963 V1032211 S ATP-grasp COG3919 V1032221 T protein tyrosine serine phosphatase COG2365 V1032229 S NA 11VH8 V1032297 M Polysaccharide biosynthesis protein COG3774 V1032314 L ATP-dependent RNA helicase COG0513 V1032329 K Inherit from firmNOG: Transcriptional regulator COG2865 V1032388 P permease COG0628 V1032392 O peptidase, M16 COG0612 V1032400 L Competence protein COG4098 V1032409 S Phosphohydrolase COG1078 V1032474 E aspartate racemase COG1794 V1032485 S Uncharacterized conserved protein (DUF2075) COG3410 V1032610 S Archaeal ATPase 0ZW9J V1032621 S Archaeal ATPase 0ZW9J V1032626 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 V1032672 E Aminotransferase class I and II COG1168 V1032715 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 V1032729 G trehalose-6-phosphate hydrolase (EC 3.2.1.93) COG0366 V1032776 P membrane protein, TerC COG0861 V1032930 S secreted protein COG4086 V1032933 K Transcriptional regulator 0Y1S3 V1032992 K May be required for sporulation (By similarity) COG1481 V1033025 J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) COG2265 V1033056 S basic membrane COG1744 V1033096 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0202 V1033102 G trehalose-6-phosphate hydrolase (EC 3.2.1.93) COG0366 V1033119 G L-xylulose 5-phosphate 3-epimerase COG3623 V1033127 L Replicative dna helicase COG0305 V1033134 P ABC transporter COG0803 V1033168 M UTP-glucose-1-phosphate uridylyltransferase COG1210 V1033341 S dak2 domain fusion protein ylov COG1461 V1033351 E amino acid COG0531 V1033404 S ATPase (AAA COG1373 V1033517 S Hydrolase COG0561 V1033612 P CBS domain protein COG1253 V1033634 S Lpxtg-motif cell wall anchor domain protein 0Y44U V1033693 G Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate COG2103 V1034178 J phosphoesterase RecJ domain protein COG0618 V1047035 U Inherit from COG: type IV secretion system protein COG3451 V1047238 E Aspartokinase COG0527 V1101418 P Binding-protein-dependent transport systems, inner membrane component COG1176 V1143165 C Na H antiporter COG1757 V1143203 M Capsular polysaccharide synthesis protein 11T25 V1264422 S NA 0ZHU9 V1389196 S Protein of unknown function (DUF2974) 0XSVF V1446896 L transposase COG0675 V1446946 E ABC transporter COG0747 V1446956 S Lpxtg-motif cell wall anchor domain protein 0Y34J V1552704 G Major Facilitator COG0477 V1796881 E aminopeptidase c COG3579 V1796918 E Aminotransferase COG0436 V1872704 S NA 0XQD4 V1882904 K Transcriptional regulator 0Y1S3 V1882964 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 V1883175 F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) COG1816 V1886924 P heavy metal translocating p-type ATPase COG2217 V1032226 S YibE F family protein COG5438 V1032371 V Beta-lactamase class C related penicillin binding protein COG1680 V1032376 P Sodium hydrogen exchanger COG0475 V1032447 S phage protein COG5410 V1032466 K parb-like partition protein COG1475 V1032542 S Protein of unknown function (DUF3383) 11UPU V1032562 K Transcriptional regulator COG1396 V1032619 T Histidine kinase 0XNMH V1032716 O May play a role in the repair of endogenous alkylation damage (By similarity) COG1066 V1032733 C FMN-dependent alpha-hydroxy acid dehydrogenase COG1304 V1032993 S UPF0052 protein COG0391 V1033053 G Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) COG0363 V1033067 J RNA methyltransferase TrmH family group 3 COG0566 V1033110 E Methionine synthase COG0620 V1033208 V Transporter COG0842 V1033271 L Membrane COG4905 V1033314 M Cell wall formation (By similarity) COG0773 V1033499 J Arginyl-tRNA synthetase COG0018 V1033752 J Glutamine amidotransferase COG2071 V1034265 C Luciferase-like COG2141 V1046974 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 V1046999 F Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) COG0775 V1047142 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) COG0322 V1047158 E amino acid COG1113 V1047197 K Fibronectin-binding protein COG1293 V1101394 G Drug resistance transporter EmrB QacA 0XNN3 V1143199 M Glycosyl Transferase COG0463 V1143512 L Transposase COG3328 V1163728 S Displays ATPase and GTPase activities (By similarity) COG1660 V1204307 S Type IV secretion-system coupling protein DNA-binding domain 0YAV5 V1204456 H nicotinamide mononucleotide transporter COG3201 V1204804 E oxalyl-CoA decarboxylase COG0028 V1237151 M UDP-N-acetylglucosamine 2-epimerase COG0381 V1684093 M Membrane-associated zinc metalloprotease COG0750 V1684104 S Outer surface protein COG3589 V1684162 L Transposase 1012J V1796838 C fumarate hydratase class II COG0114 V1806574 P H( )-stimulated, divalent metal cation uptake system (By similarity) COG1914 V1806578 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 V1806580 M mur ligase COG0769 V1806590 C uridylyltransferase COG1085 V1806607 E amino acid COG1113 V1880123 E branched-chain amino acid transport system II carrier protein COG1114 V1883319 S NA 0XV6C V1883383 V abc transporter COG1132 V1886316 P heavy metal translocating p-type ATPase COG2217 V1032208 P hemerythrin hhe cation binding domain protein COG2461 V1032331 E Cysteine desulfurase COG1104 V1032332 D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) COG4477 V1032337 D cell division protein COG0772 V1032417 T response regulator COG3279 V1032492 S Hydrolase COG1011 V1032493 S ABC transporter COG2984 V1032571 C Flavocytochrome c COG1053 V1032582 S NA 11QCR V1032635 H riboflavin biosynthesis protein ribF COG0196 V1032639 K Transcription elongation factor NusA COG0195 V1032681 C L-lactate dehydrogenase COG0039 V1032710 J NOL1 NOP2 sun family protein COG0144 V1032794 G mannitol-1-phosphate 5-dehydrogenase COG0246 V1032838 M Glyco_25 COG3757 V1032851 K Transcriptional regulator 0XUC3 V1033010 S ATPase AAA superfamily 0XSDB V1033049 P transporter COG0471 V1033099 F dihydroorotase COG0044 V1033169 I Acetyl-CoA acetyltransferase COG0183 V1033176 T Histidine kinase COG0642 V1033362 G iic component COG1455 V1033464 E glutamine synthetase COG0174 V1033580 S Hydrolase COG0561 V1033591 K Transcriptional regulator COG1609 V1033622 S ABC superfamily ATP binding cassette transporter, permease 0YYAC V1033627 S Rib/alpha-like repeat 10008 V1033638 H 1,4-dihydroxy-2-naphthoate octaprenyltransferase COG1575 V1033718 K transcriptional regulator COG1737 V1033786 K transcriptional regulator COG1737 V1034215 V Mate efflux family protein COG0534 V1034232 S surface protein 11NE4 V1034271 G Drug resistance transporter EmrB QacA 0XNN3 V1034293 S MgsA AAA+ ATPase C terminal 11N61 V1046996 H folylpolyglutamate synthase Dihydrofolate synthase COG0285 V1047209 E Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate (By similarity) COG1473 V1101399 F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) COG0516 V1101424 M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) COG0766 V1149113 S integral membrane protein 0XS1S V1162585 L Terminase, large subunit COG4626 V1204705 T Histidine kinase COG2972 V1206511 U (ABC) transporter COG4473 V1336063 S Inherit from NOG: DNA repair protein 0XQPN V1684075 V Beta-lactamase COG1680 V1796888 G Major Facilitator COG0477 V1819389 H Pyridoxal kinase COG2240 V1828756 E ABC transporter COG0747 V1872726 L Competence protein COG1555 V1872733 K Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) COG2344 V1883274 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 V1883275 G L-ribulose-5-phosphate 4-epimerase COG0235 V1885173 F 2',3'-cyclic-nucleotide 2'-phosphodiesterase EC 3.1.4.16 COG0737 V1886264 G phosphoriboisomerase A COG0120 V1890909 M Glycosyl transferase, family 2 COG1215 V1891106 M phage tail tape measure protein COG5283 V1891137 M Capsular exopolysaccharide family COG0489 V1032302 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 V1032356 C Dehydrogenase COG1012 V1032359 P transporter COG0598 V1032521 F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) COG0125 V1032555 M Cell wall formation (By similarity) COG0812 V1032558 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 V1032627 G trehalose-6-phosphate hydrolase (EC 3.2.1.93) COG0366 V1032688 S ABC transporter, ATP-binding protein COG0488 V1032693 E Oligoendopeptidase f COG1164 V1032698 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 V1032700 E Extracellular solute-binding protein, family 5 COG4166 V1032825 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 V1032920 K catabolite control protein a COG1609 V1032968 P p-type atpase COG2217 V1033050 C (citrate (pro-3S)-lyase ligase COG3053 V1033186 V ABC transporter COG1131 V1033267 M Glycosyl transferase (Group 1 COG0438 V1033440 E ABC superfamily ATP binding cassette transporter ABC protein COG4608 V1033462 J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) COG0324 V1033485 G Xylose Isomerase Domain-Containing protein 11ISM V1033518 K Transcriptional regulator COG1396 V1033538 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) COG1518 V1033559 G Triose-phosphate isomerase COG0149 V1033643 M Glyco_25 COG3757 V1033650 S NA 0Z1CQ V1033667 H Catalyzes the formation of S-adenosylmethionine from methionine and ATP COG0192 V1033672 M Glyco_25 COG3757 V1033723 K Transcriptional regulator COG1609 V1034206 O FeS assembly protein SUFB COG0719 V1034210 L Hydrolase, tatD family COG0084 V1034236 S tail component COG4722 V1047204 S Membrane COG1434 V1047229 S Lpxtg-motif cell wall anchor domain protein 0Y34J V1047239 E homoserine dehydrogenase COG0460 V1047268 P aluminum resistance protein COG4100 V1047272 G IIC component COG1455 V1047293 L Transposase (IS4 family 11HCS V1101199 L transposase COG0675 V1101502 C Flavocytochrome c COG1053 V1162625 L transposase IS116 IS110 IS902 family protein COG3547 V1162660 L Transposase (IS4 family 11HCS V1336048 E amino acid COG0531 V1338861 T domain protein COG3887 V1684159 P ABC transporter (permease) COG0601 V1684165 E ABC transporter COG0834 V1755602 M cyclopropane-fatty-acyl-phospholipid synthase COG2230 V1796878 P phosphonate ABC transporter, periplasmic phosphonate-binding protein COG3221 V1806576 U hydrolase, family 8 0Y1JM V1806605 G beta-phospho-glucomutase COG0637 V1806641 E ABC transporter COG0747 V1806643 S CAAX amino terminal protease family 0XW1D V1807929 S NA 0XYMV V1808252 C Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) COG0554 V1819364 S degv family COG1307 V1880009 M Glycosyl Transferase COG0463 V1880091 L Transposase 1012J V1883164 M phosphoglycerol transferase alkaline phosphatase superfamily protein COG1368 V1884415 G ABC transporter COG1653 V1884554 J Tryptophanyl-tRNA synthetase COG0180 V1884715 L muts2 protein COG1193 V1032217 P phosphonate abc transporter COG3639 V1032295 M glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC COG1887 V1032339 D Rod shape-determining protein mreb COG1077 V1032360 S Metallo-Beta-Lactamase COG0595 V1032361 P ABC transporter COG0395 V1032406 C NADPH-dependent glycerol-3-phosphate dehydrogenase COG0240 V1032435 S Phage Tail Tape Measure Protein COG5283 V1032444 S Uncharacterized protein conserved in bacteria (DUF2213) COG3566 V1032446 S Phage-associated protein, HI1409 family COG3567 V1032495 S abc transporter atp-binding protein COG1101 V1032564 S ATP GTP Binding Protein 0XQ3U V1032607 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 V1032616 P Phosphate ABC transporter COG0581 V1032633 P ABC transporter, permease COG3833 V1032636 J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) COG0130 V1032649 T response regulator COG0745 V1032655 P transporter COG0471 V1032657 O Protease HtpX homolog COG0501 V1032660 H pantothenic acid kinase COG1072 V1032675 O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) COG1281 V1032701 P ABC transporter (Permease COG1173 V1032764 G oxidoreductase COG0673 V1032926 C ferredoxin--nadp reductase COG0492 V1032931 M Glycosyl Transferase COG0463 V1032934 S NA 0Z3PS V1032955 G pts system COG1455 V1032996 J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) COG1206 V1033021 P CBS domain protein COG1253 V1033028 J Methylates ribosomal protein L11 (By similarity) COG2264 V1033079 G Phosphohexokinase COG0205 V1033098 F carbamoyl-phosphate synthetase glutamine chain COG0505 V1033125 S degv family COG1307 V1033163 M udp-glucose 4-epimerase COG1087 V1033294 K SIR2 family COG0846 V1033295 L DNA polymerase iii COG2176 V1033327 F carbamoyl-phosphate synthetase glutamine chain COG0505 V1033433 S Erf family 11KYA V1033678 S dinuclear metal center protein, YbgI family COG0327 V1033724 L recombination factor protein RarA COG2256 V1034192 K Participates in transcription elongation, termination and antitermination (By similarity) COG0250 V1034305 I Diacylglycerol kinase COG1597 V1034338 K Transcriptional regulator 0Y1S3 V1047058 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 V1047060 E ABC transporter COG0747 V1047267 L ATP-dependent DNA helicase RecQ COG0514 V1143169 S Bacteriophage protein COG3299 V1143202 M Glycosyl transferase, family 2 0ZVME V1143260 C L-lactate COG1620 V1163647 E Transporter COG3104 V1203582 S Rib/alpha-like repeat 10008 V1204719 V ABC transporter COG1132 V1204806 E amino acid COG0531 V1237104 U Competence protein COG2804 V1338876 P pyridine nucleotide-disulfide oxidoreductase COG0446 V1338896 G PTS System COG1299 V1552752 O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) COG1219 V1574834 S NA 0ZHU9 V1684092 J ribosomal RNA small subunit methyltransferase b COG0144 V1755601 K Transcriptional regulator COG1396 V1796864 E ABC transporter COG3839 V1806577 G 6-phospho-beta-glucosidase (EC 3.2.1.86) COG2723 V1806611 C d-lactate dehydrogenase COG1052 V1806649 S Membrane COG3619 V1807976 L Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) COG0389 V1880033 C Dehydrogenase COG1304 V1882220 T gtp-binding protein typa COG1217 V1883302 L Transposase 1012J V1885083 S Metal Dependent Phosphohydrolase COG3481 V1886009 L Transposase 1012J V1886365 J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0009 V1891194 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates COG1122 V1032293 H nh(3)-dependent nad( ) synthetase COG0171 V1032300 S Sex pheromone COG4851 V1032342 C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) COG0055 V1032405 M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) COG0682 V1032494 S ABC transporter, permease COG4120 V1032515 P Ion channel COG1226 V1032523 L dna polymerase iii COG0470 V1032527 O Peptidase M22 Glycoprotease COG1214 V1032557 S TIGR00159 family COG1624 V1032576 E amino acid COG1113 V1032593 E amino acid COG0531 V1032650 S YycI protein COG4853 V1032683 L transposase COG0675 V1032684 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 V1032737 H synthase COG0142 V1032750 J 30S ribosomal protein S2 COG0052 V1032917 S NA COG4990 V1033032 J histidyl-tRNA synthetase COG0124 V1033048 E aminopeptidase c COG3579 V1033052 C Citrate lyase beta COG2301 V1033075 D Chromosome Partitioning Protein COG1192 V1033082 L UPF0246 protein COG3022 V1033089 S Membrane 0XQ7F V1033094 P ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates COG1122 V1033138 M Involved in formation and maintenance of cell shape (By similarity) COG1792 V1033157 S ErfK YbiS YcfS YnhG COG1376 V1033182 S CAAX amino terminal protease family 0XW1D V1033203 O SPFH domain, Band 7 family protein COG0330 V1033213 H Polyprenyl synthetase COG0142 V1033215 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1570 V1033246 F nucleoside hydrolase COG1957 V1033253 J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) COG0482 V1033304 E Arginine dihydrolase COG2235 V1033331 H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) COG1985 V1033348 I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) COG0344 V1033374 E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) COG0083 V1033426 G PTS system mannose fructose sorbose family transporter subunit IID COG3716 V1033463 P aluminum resistance protein COG4100 V1033467 S ABC superfamily ATP binding cassette transporter membrane protein 0YJE9 V1033470 S of methanol dehydrogenase type COG1512 V1033569 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 V1033608 G Glucose uptake protein COG4975 V1033679 E Threonine synthase COG0498 V1033687 K transcriptional regulator 0XR9S V1033722 E peptidase M24 COG0006 V1034272 V abc transporter atp-binding protein COG1131 V1034327 G extracellular solute-binding protein family 1 COG1653 V1047243 E Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) COG3842 V1101377 G GlcNAc 6-P deacetylase COG1820 V1101405 G Drug resistance transporter EmrB QacA 0XNN3 V1143264 V Abi-like protein COG4823 V1150390 S Outer surface protein COG3589 V1199360 V Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) COG1136 V1203280 S Bacteriophage protein COG3299 V1203697 H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) COG0190 V1204507 K Transcriptional regulator 0XRI9 V1204587 D DivIVA protein COG3599 V1204704 G PTS System COG1445 V1204773 P Drug resistance transporter EmrB QacA 0XNN3 V1237154 Q acetyl xylan esterase COG3458 V1338888 F nucleoside hydrolase COG1957 V1338890 S Conserved hypothetical protein 698 COG2855 V1366239 L Single-stranded-DNA-specific exonuclease (RecJ) COG0608 V1366241 L Transposase COG3436 V1389191 L Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) COG0116 V1398941 L Transposase COG3328 V1552707 L ATP-dependent RNA helicase COG0513 V1684142 L Transposase COG3328 V1684177 F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) COG0516 V1755542 L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) COG0582 V1796866 P Sodium hydrogen exchanger COG0475 V1806651 M Cell wall-associated hydrolase COG0791 V1806656 M Glycosyl transferase, wecb taga cpsf family COG1922 V1882963 E Inner membrane transporter yjeM 174IZ@proNOG V1882979 P phosphate ABC transporter (Permease COG0581 V1883276 S Competence protein COG4469 V1883293 L transposase (IS4 family) protein 0XQ88 V1883323 L Inherit from COG: transposase COG2826 V1884510 T Histidine kinase 0XNMH V1884653 G PTS system mannitol-specific COG2213 V1884791 E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 V1885058 L Integrase COG0582 V1885117 L reverse transcriptase COG3344 V1886313 O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) COG0465 V1891162 D modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) COG4477 V1891189 M NA 0YESU V1032218 P phosphonate abc transporter COG3638 V1032225 S multi-transmembrane protein COG5438 V1032335 L recombination factor protein RarA COG2256 V1032354 K transcriptional regulator 11HA7 V1032395 S Transcriptional regulator COG1426 V1032413 F permease COG2233 V1032421 S UPF0348 protein COG1323 V1032438 S Protein of unknown function (DUF3383) 11UPU V1032465 K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) COG1475 V1032468 J gtp-binding protein COG0012 V1032469 S integral membrane protein COG4858 V1032490 C reductase COG0656 V1032550 S hydrolase COG0561 V1032570 T serine threonine protein phosphatase COG0639 V1032597 S Hydrolase COG0561 V1032598 K Transcriptional regulator COG1349 V1032605 M Glyco_25 COG3757 V1032630 G ABC transporter, ATP-binding protein COG3839 V1032634 K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) COG1420 V1032687 S Membrane COG2966 V1032734 S NA 11GVV V1032736 H 1,4-dihydroxy-2-naphthoate octaprenyltransferase COG1575 V1032741 C cytochrome d ubiquinol oxidase, subunit ii COG1294 V1032742 C (Ubiquinol oxidase) subunit I COG1271 V1032752 F Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) COG0528 V1032781 L DNA repair exonuclease COG0420 V1032836 L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 V1032837 S S1 RNA binding domain protein COG2996 V1032909 L Primosomal protein DnaI COG1484 V1032918 E Releases the N-terminal proline from various substrates (By similarity) COG0596 V1032928 I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) COG1502 V1032954 G glycoside hydrolase, family 1 COG2723 V1032957 G 6-phospho-beta-glucosidase (EC 3.2.1.86) COG2723 V1032999 L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) COG0164 V1033146 J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate COG0617 V1033174 P (ABC) transporter COG0614 V1033200 J asparaginyl-tRNA synthetase COG0017 V1033248 C Aldo Keto reductase COG4989 V1033293 S Membrane COG2323 V1033297 K Transcriptional regulator 0Y1S3 V1033403 S Archaeal ATPase 0ZW9J V1033431 S phage protein COG5410 V1033434 L Protein of unknown function (DUF1351) 0YIT0 V1033454 K transcriptional regulator MERR family COG0789 V1033456 S phospho-beta-glycosidase 11PU7 V1033568 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 V1033576 L transposase COG0675 V1033588 J glycyl-tRNA synthetase, alpha subunit COG0752 V1033594 K Inherit from firmNOG: Transcriptional regulator COG2865 V1033692 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 V1033726 T phosphodiesterase 0XNMH V1033776 K Transcriptional regulator COG2188 V1034323 L transposase (IS4 family) protein 0XQ88 V1034324 E Dipeptidase COG0624 V1034346 H phosphomethylpyrimidine kinase COG0351 V1047164 F serine threonine protein phosphatase COG1409 V1047203 C glycerophosphoryl diester phosphodiesterase COG0584 V1047241 S ABC transporter COG4152 V1047270 K Transcriptional regulator COG0583 V1047294 M Cell surface protein 11GRZ V1101427 V abc transporter atp-binding protein COG1131 V1101429 C Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) COG1018 V1150407 U Inherit from COG: type IV secretion system protein COG3451 V1150703 G Major Facilitator superfamily 0XQKC V1162582 S tail component COG4722 V1162609 S Membrane 11R75 V1163617 S Xanthine uracil vitamin C permease COG2252 V1163775 S alpha beta COG1073 V1163789 F deoxynucleoside kinase COG1428 V1204497 S Protein of unknown function (DUF805) 0ZYU9 V1204788 L excinuclease COG0178 V1210631 S NA 0ZHU9 V1237098 E ABC transporter COG0687 V1301210 L Transposase COG3328 V1320212 S NA 0ZHU9 V1337289 K Transcriptional regulator, TetR family COG1309 V1338863 G Pyruvate kinase COG3848 V1338864 V ABC transporter COG1132 V1338894 V type I restriction-modification system COG0286 V1389192 S Phage Portal Protein COG4695 V1448274 S surface protein 11NE4 V1796870 E Inherit from COG: amidohydrolase COG1473 V1796916 C Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) COG0282 V1799409 S PG1 protein, homology to Homo sapiens 0Y13W V1806589 S ybbr family COG4856 V1806642 I CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) COG4670 V1808244 E Transporter COG3104 V1828842 S NA 123QA V1828853 M exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase (EC 2.7.8.6) COG2148 V1872736 S Replication initiator protein 0XR3Z V1872763 C nitroreductase COG0778 V1880004 S SNARE associated Golgi protein 11VBC V1880919 S alpha beta COG1073 V1882981 S LysM domain 0YPBZ V1883115 U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) COG0653 V1884241 L Inherit from COG: transposase COG2826 V1884587 J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) COG0162 V1887057 E ABC transporter COG4166 V1891156 V ABC transporter, permease COG0577 V1891412 S Hydrolase COG4814 V1032232 F Phosphoribosyl pyrophosphate synthase COG0462 V1032298 N, U flagellar rod assembly protein muramidase flgj COG1705 V1032426 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) COG0706 V1032431 E amino acid AbC transporter COG0765 V1032462 H thiamine biosynthesis lipoprotein COG1477 V1032519 L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) COG0353 V1032525 G Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) COG0313 V1032526 I Acyl-ACP thioesterase COG3884 V1032561 K antiterminator COG3711 V1032585 E, T (ABC) transporter COG0834 V1032613 I acidPPc COG0671 V1032620 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 V1032663 E abc transporter atp-binding protein COG1126 V1032682 S Cbs domain protein COG0517 V1032724 S intracellular protease Pfpi family COG0693 V1032735 C NADH dehydrogenase COG1252 V1032751 J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) COG0264 V1032839 I Esterase lipase COG0657 V1032924 S integral membrane protein COG4478 V1032972 S host cell surface-exposed lipoprotein 11S42 V1033008 G Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) COG0061 V1033013 T response regulator COG3279 V1033043 E L-asparaginase COG0252 V1033167 S ribonuclease BN COG1295 V1033258 C An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0536 V1033296 S DNA-entry nuclease 12175 V1033391 O feS assembly ATPase SufC COG0396 V1033402 H triphosphoribosyl-dephospho-CoA synthase COG1767 V1033424 K transcriptional regulator, lysR family COG0583 V1033428 G pts system COG3444 V1033439 E, P Oligopeptide ABC transporter, permease protein AppB COG0601 V1033496 T phosphatase COG0631 V1033531 G 6-phosphogluconolactonase (EC 3.1.1.31) COG2706 V1033547 E, G Transporter COG0697 V1033635 G phosphoglycerate mutase COG0406 V1033644 S NA 0YZ7D V1033669 E Dipeptidase COG4690 V1033702 S Lpxtg-motif cell wall anchor domain protein 0Y44U V1033740 K regulatoR COG2390 V1034181 K pur operon repressor COG0503 V1034186 L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 V1034207 I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) COG0416 V1034255 Q oxidoreductase COG1233 V1034266 E Cysteine desulfurase COG1104 V1034322 L Transposase COG3464 V1034330 E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 V1046990 I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) COG0020 V1047001 C reductase COG0656 V1047006 S SAM-dependent methyltransferase COG2384 V1047012 P p-type ATPase COG2217 V1047187 S NA 0YNCM V1047200 K transcriptional regulator COG1609 V1047210 C Manganese-dependent inorganic pyrophosphatase COG1227 V1047237 G phosphoglycerate mutase COG0406 V1047266 K transcriptional regulator COG1737 V1101263 S NA 0YDBQ V1101375 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 V1101403 E Peptidase m42 family protein COG1363 V1143334 S ABC transporter substrate-binding protein 0XSZJ V1199406 H pantothenic acid kinase COG1072 V1203288 I PAP2 Family COG0671 V1206528 C glycerophosphoryl diester phosphodiesterase COG4781 V1237131 L Transposase COG3666 V1338859 S Lpxtg-motif cell wall anchor domain protein 0Y34J V1482386 S NA 0ZHU9 V1595753 S NA 0ZHU9 V1684090 S acetyltransferase COG0110 V1684091 G Major Facilitator 0XPHU V1755597 K Transcriptional regulator COG0583 V1806591 S transcriptional regulator COG4470 V1806648 S NA 0YWIA V1872768 G Major Facilitator 0ZVCH V1879977 L Transposase COG3328 V1883295 K Transcriptional regulator 0XRI9 V1883307 G mannose-6-phosphate isomerase COG1482 V1884289 O Tetratricopeptide tpr_2 repeat protein COG3914 V1884406 H 5-formyltetrahydrofolate cyclo-ligase COG0212 V1884439 E homocysteine methyltransferase COG2040 V1884608 S Uncharacterized conserved protein (DUF2075) COG3410 V1891419 P Transporter 0ZVUY V1032222 G IIa component COG1762 V1032223 F Nucleoside deoxyribosyltransferase COG3613 V1032228 M Cell wall formation (By similarity) COG1181 V1032379 S CAAX amino terminal protease family protein 0XUJM V1032394 I reductase 0XNW1 V1032397 L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) COG0468 V1032398 M Glycosyl transferase, family 4 COG0472 V1032422 S Nucleic acid-binding protein COG1399 V1032464 M Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) COG0357 V1032547 S Uncharacterized protein conserved in bacteria (DUF2213) COG3566 V1032552 C phosphate acetyltransferase COG0280 V1032599 I Phospholipase, patatin family COG4667 V1032600 S hydrolase COG0561 V1032608 U Signal peptidase i COG0681 V1032656 S LemA family COG1704 V1032671 U Competence protein COG1459 V1032702 E, P ABC transporter COG0444 V1032708 C Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) COG1304 V1032720 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0588 V1032772 F UPF0207 protein COG1896 V1032820 J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COG0094 V1032929 S Caulimovirus viroplasmin COG3341 V1032974 K Phage antirepressor protein KilAC domain COG3645 V1032987 S (LipO)protein COG3212 V1032988 S (LipO)protein COG3212 V1032995 L Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) COG4974 V1033054 S ABC transporter (Permease) COG1079 V1033139 D Rod shape-determining protein mreb COG1077 V1033145 S YitT family COG1284 V1033147 S hemolysin iii COG1272 V1033162 G beta-galactosidase small subunit COG3250 V1033166 J Removes the N-terminal methionine from nascent proteins (By similarity) COG0024 V1033173 P ABC transporter COG1120 V1033306 O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COG0544 V1033332 H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) COG0807 V1033392 E Cysteine desulfurase COG0520 V1033447 S Uncharacterised ACR, COG2135 11Z12 V1033451 E amino acid COG0531 V1033472 G tagatose-6-phosphate kinase COG1105 V1033497 J Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) COG0223 V1033498 M ErfK YbiS YcfS YnhG COG1376 V1033511 F serine threonine protein phosphatase COG1409 V1033555 E asparagine synthetase A COG2502 V1033570 G May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) COG1162 V1033585 G, M Nad-dependent epimerase dehydratase COG0702 V1034193 S integral membrane protein COG5523 V1034199 F Catalyzes the conversion of dihydroorotate to orotate (By similarity) COG0167 V1034204 J HAD-superfamily hydrolase subfamily IA variant 3 COG0637 V1034248 M Glyco_25 COG3757 V1034251 S SAM-dependent methyltransferase 0YNVR V1034286 K transcriptional Regulator LysR family 11Z5Z V1034318 S Abortive infection protein COG1106 V1034333 L uracil-dna glycosylase COG1573 V1046980 S Phage head morphogenesis protein COG2369 V1046998 M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) COG0707 V1047068 J TRNA binding domain protein COG0073 V1047073 G, K ROK family COG1940 V1047132 S Phage nucleotide-binding protein 0YG3Q V1047163 K TRANSCRIPTIONAl REGULATOR GntR family COG2186 V1047169 L DNA polymerase iii, delta' subunit COG1466 V1047299 S Xanthine uracil vitamin C permease COG2252 V1101417 J pseudouridine synthase COG0564 V1143172 S NA 11WKE V1149272 L crispr-associated protein COG3513 V1162586 L Integrase COG0582 V1162995 M Glycosyl Transferase COG1442 V1163705 L transposase IS116 IS110 IS902 family protein COG3547 V1204487 M NA 0YESU V1338897 V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) COG1136 V1338909 G sucrose-6-phosphate hydrolase COG1621 V1493883 S NA 0ZHU9 V1684078 M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) COG1589 V1684149 K transcriptional regulator DeoR family COG1349 V1684169 T Transcriptional regulator COG0664 V1755580 C Dehydrogenase COG0039 V1796922 O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) COG1220 V1806595 G pts system COG1762 V1806599 K Transcriptional regulator, ARAC family COG2207 V1806636 O ATP-dependent Clp protease, proteolytic subunit COG0740 V1806657 K (GntR family) (Transcriptional regulator COG2188 V1807974 O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 V1828716 J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 V1828717 M Glycosyl transferase, family 2 COG1215 V1872685 P Cobalt transport protein COG0619 V1872751 M Cell surface protein 11GRZ V1882168 L Transposase 11J2V V1883278 V ABC transporter COG1131 V1883305 S NA 11NI8 V1883370 G Glycogen debranching enzyme COG1523 V1883371 K Transcriptional regulator COG1737 V1884620 L Adenine-specific COG0827 V1890913 P Lipoprotein COG1464 V1891120 Q amidohydrolase COG1228 V1032210 O Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) COG0602 V1032216 P phosphonate abc transporter COG3639 V1032303 I Diacylglycerol kinase COG1597 V1032304 S Membrane COG0670 V1032306 S integral membrane protein 11UKN V1032311 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) COG0632 V1032312 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 V1032399 S protein family UPF0029, Impact, N-terminal protein COG1739 V1032404 T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) COG1493 V1032448 L terminase (Small subunit) COG3728 V1032513 J 50s ribosomal protein L10 COG0244 V1032545 S Uncharacterized protein conserved in bacteria (DUF2184) COG4834 V1032573 S Prophage Lp1 protein 65 0XSDQ V1032614 P phosphate COG0226 V1032615 P phosphate abc transporter COG0573 V1032617 P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) COG1117 V1032618 T regulator COG0745 V1032651 S domain protein COG1235 V1032670 K transcriptional regulatory protein COG0217 V1032680 J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) COG0193 V1032685 M Inherit from COG: domain protein COG4990 V1032722 P cation diffusion facilitator family transporter COG1230 V1032726 K, T lytTr DNA-binding domain protein COG3279 V1032738 H Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) COG2226 V1032754 S Phage Portal Protein COG4695 V1032768 C glycerophosphoryl diester phosphodiesterase COG0584 V1032783 S prophage protein 0ZR61 V1032791 P Transport of potassium into the cell (By similarity) COG3158 V1032814 J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) COG0092 V1032826 F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) COG0563 V1032846 G fructokinase COG1940 V1032850 S MgtC SapB transporter COG1285 V1032925 S dedA family COG0586 V1032940 M n-acetylmuramoyl-l-alanine amidase COG5632 V1032941 M defense response to bacterium COG1705 V1032985 K Transcriptional regulator COG1846 V1032991 S ABC transporter, permease COG0390 V1032994 S Membrane 123WC V1033000 K Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) COG1161 V1033044 K Transcriptional regulator COG1737 V1033081 V type I restriction-modification system COG0286 V1033084 G phosphoglycerate mutase COG0406 V1033124 V Beta-lactamase COG1680 V1033136 P ABC transporter COG1108 V1033212 J Hemolysin A COG1189 V1033251 J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) COG0030 V1033263 E Aspartokinase COG0527 V1033303 K transcriptional regulator, lysR family COG0583 V1033370 S Cell wall-active antibiotics response protein (DUF2154) 11V5T V1033468 F permease COG2233 V1033481 P ABC transporter, permease COG1175 V1033482 G ABC transporter, ATP-binding protein COG3839 V1033532 S Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) COG0220 V1033598 S Glutamine amidotransferase COG3442 V1033677 M Glycosyl Transferase COG1442 V1033700 J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) COG0060 V1033707 C Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate (By similarity) COG0329 V1033758 S (LipO)protein COG3212 V1034213 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0588 V1034264 S Hydrolase COG0561 V1034276 E Acetylornithine deacetylase COG0624 V1034287 K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) COG1974 V1034298 S Major tail protein 0Y77V V1034359 S Protein of unknown function (DUF3021) 0Y5NF V1046989 O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0576 V1047014 C Nitroreductase COG0778 V1047016 M Glycosyl transferase, family 2 COG1215 V1047055 G PTS system glucitol sorbitol-specific 1253B V1047056 S acyl-CoA thioesterase 0YKTK V1047098 S phage tape measure protein COG5283 V1047155 M Glycosyl transferase family 8 0Y03U V1047274 K Transcriptional regulator 0Y9V9 V1101204 S Transglycosylase SLT domain COG5283 V1101484 S Short-chain dehydrogenase reductase SDR COG1028 V1101493 G resistance protein 0XNN3 V1101583 S CAAX amino terminal protease family protein 0XUJM V1143272 V Endonuclease COG1403 V1143367 V Peptidase C39 family COG2274 V1149017 S phage tape measure protein COG5283 V1150388 E Inherit from COG: amidohydrolase COG1473 V1150392 G domain protein COG1501 V1162576 K AntA/AntB antirepressor COG3645 V1162584 L helicase COG1061 V1163048 I esterase COG0657 V1163680 E, G Transporter COG0697 V1163759 S basic membrane COG1744 V1203404 J phenylalanyl-tRNA synthetase (alpha subunit) COG0016 V1204522 S Protein of unknown function (DUF3737) 0XTHF V1204643 K Transcriptional regulator 0Y1S3 V1204733 E L-serine dehydratase, iron-sulfur-dependent, beta subunit COG1760 V1206514 F Phosphoribosyl pyrophosphate synthase COG0462 V1237155 E Extracellular solute-binding protein, family 5 COG4166 V1338913 L transposase COG2826 V1366248 S Inherit from NOG: LPXTG-motif cell wall anchor domain protein 0YEBJ V1389024 L transposase COG2826 V1552701 U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins COG0706 V1552787 S Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) COG1354 V1552799 F GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) COG1160 V1552800 J Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) COG0539 V1598280 S integral membrane protein 11QKN V1614077 S ABC superfamily ATP binding cassette transporter, permease 0YYAC V1684102 S NA 11WKE V1796839 C citrate lyase, alpha COG3051 V1796871 E Binding-protein-dependent transport systems, inner membrane component COG1177 V1796880 S Metal Dependent Phosphohydrolase COG1418 V1796890 S Lysm domain protein 11U6T V1796919 H Phosphopantothenoylcysteine decarboxylase COG0452 V1806601 G aldose 1-epimerase COG2017 V1806619 L dna replication protein COG1484 V1819410 T response regulator COG0745 V1828755 S Prophage Lp1 protein 65 0XSDQ V1880095 S NA 11VH8 V1882929 L Pfam:Transposase_8 COG2963 V1883162 F nucleoside hydrolase COG1957 V1883207 S Hydrolase COG0561 V1883240 L Nudix family COG0494 V1884299 T Tetracycline resistance protein COG0480 V1884645 G Glycerate kinase COG1929 V1884654 E Extracellular solute-binding protein, family 5 COG4166 V1884657 T response regulator COG0745 V1884709 K Transcriptional regulator 0XRI9 V1884818 L Transposase 1012J V1885076 C Flavocytochrome c COG1053 V1885134 S surface protein 11NE4 V1886373 G PTS System COG1445 V1032214 L Dna-3-methyladenine glycosylase i COG2818 V1032227 S NA 0Z3EH V1032230 E abc transporter atp-binding protein COG1126 V1032348 C it plays a direct role in the translocation of protons across the membrane (By similarity) COG0356 V1032414 K HTH_XRE COG1396 V1032423 T response regulator COG0745 V1032460 S Nadph-dependent fmn reductase COG0431 V1032461 T protein tyrosine serine phosphatase COG2365 V1032516 J methyltransferase COG2813 V1032556 P putrescine abc transporter COG1177 V1032584 E ABC transporter COG0765 V1032586 E abc transporter atp-binding protein COG1126 V1032642 I Phosphatidate cytidylyltransferase COG0575 V1032753 J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) COG0233 V1032755 O ATP-dependent Clp protease, proteolytic subunit COG0740 V1032774 L 3-methyladenine DNA glycosylase COG2094 V1032808 J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) COG0088 V1032824 J Binds to the 23S rRNA (By similarity) COG0200 V1032829 J 30S ribosomal protein S1 COG0539 V1032843 S Hydrolase COG4814 V1032887 T domain protein COG3480 V1032913 L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) COG0266 V1032938 O Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) COG2039 V1032953 G, K ROK family COG1940 V1032980 S integral membrane protein COG1284 V1033004 O Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis COG4862 V1033007 S RelA SpoT domain protein COG2357 V1033037 H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) COG1057 V1033066 K RNA Polymerase 12307 V1033083 S Hydrolase COG1073 V1033093 P Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) COG0619 V1033100 F aspartate transcarbamylase COG0540 V1033120 G decarboxylase COG0269 V1033131 M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) COG0472 V1033155 V Beta-lactamase COG1680 V1033188 G BadF BadG BcrA BcrD COG2971 V1033199 L DNA replication protein DnaD COG3935 V1033201 S NA 0ZMEB V1033217 J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) COG0231 V1033231 S NA 0XNUC V1033236 K AntA/AntB antirepressor COG3645 V1033255 S tpr repeat-containing protein 11U03 V1033264 E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) COG0253 V1033269 S integral membrane protein COG0392 V1033328 J Pseudouridine synthase COG0564 V1033378 K transcriptional regulator COG2378 V1033427 G PTS System COG3715 V1033444 O Heat shock protein COG0071 V1033450 C Dehydrogenase COG0111 V1033564 E Peptidase family M23 11ZGW V1033565 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 V1033587 L Involved in DNA repair and RecF pathway recombination (By similarity) COG1381 V1033602 S hydrolase COG1073 V1033614 J Arginyl-tRNA synthetase COG0018 V1033685 L Resolvase COG2452 V1033757 J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) COG0008 V1033781 S Rhomboid family COG0705 V1034224 J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) COG0216 V1034230 C L-lactate dehydrogenase COG0039 V1034335 L Transposase (IS4 family 11HCS V1047133 V Hnh endonuclease 0XUCJ V1047141 L Integrase COG0582 V1047152 E asparagine synthetase COG0367 V1047159 C Dehydrogenase COG1454 V1047182 S MMPL domain protein COG2409 V1047195 P Na H antiporter COG0025 V1047196 S degv family COG1307 V1101540 F Nudix family COG1051 V1143198 S -acetyltransferase COG0110 V1143250 M Glyco_25 COG3757 V1143301 O feS assembly protein SufD COG0719 V1143368 T response regulator COG3279 V1143479 U Transport protein ComB 0XX01 V1162548 S Domain of unknown function (DUF955) 0XW04 V1162983 E GDSL-like Lipase/Acylhydrolase COG2755 V1163626 L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0188 V1163801 G Major Facilitator 0ZVCH V1204488 G PTS System COG1762 V1204779 E, P ABC transporter COG0444 V1338900 K Transcriptional regulator 0Y1S3 V1384195 S NA 0ZHU9 V1396140 S NA 0ZHU9 V1398758 S UPF0398 protein COG4474 V1458441 D ftsk SpoIIIE family protein COG1674 V1552805 T Phoh family COG1702 V1684146 O Matrixin COG5549 V1684190 K Inherit from firmNOG: Transcriptional regulator COG2865 V1755545 M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) COG1159 V1796921 S phosphorylase 11F11 V1806626 H, I holo-ACP synthase CitX COG3697 V1806627 G isomerase COG0698 V1819375 E ornithine carbamoyltransferase COG0078 V1828791 S Membrane 11YSX V1828832 T Histidine kinase 0XNMH V1880904 S Transposase 11N3I V1882180 S Membrane Spanning Protein COG1277 V1882215 L Inherit from COG: transposase COG2826 V1882343 J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) COG0480 V1882934 L Inherit from COG: transposase COG2826 V1882938 S Endonuclease Exonuclease phosphatase 0XNVA V1882978 G, K ROK family COG1940 V1882980 I esterase COG0657 V1883114 J ribosomal subunit Interface protein COG1544 V1883170 L transposase COG0675 V1884532 S Protein of unknown function (DUF3383) 11UPU V1885078 E branched-chain amino acid transport system II carrier protein COG1114 V1885122 L transposase COG2826 V1032209 O fes assembly suf system protein COG2151 V1032322 M Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) COG0796 V1032396 I cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase COG0558 V1032425 S ybak prolyl-trna synthetase COG3760 V1032428 J rrna methyltransferase COG0566 V1032429 K Transcriptional regulator COG1733 V1032580 S Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) 1248I V1032596 K Transcriptional regulator COG2188 V1032662 E ABC transporter substrate-binding protein COG0834 V1032666 G phosphoglycerate mutase COG0406 V1032673 G mannose-6-phosphate isomerase COG1482 V1032691 S Protein of unknown function (DUF554) COG1811 V1032694 S Death-On-Curing Family COG3654 V1032719 T 2'-3'-cyclic nucleotide COG4639 V1032749 L Methyltransferase COG4123 V1032769 S Antibiotic biosynthesis monooxygenase 0Y2XH V1032773 E ABC transporter, ATP-binding protein COG1126 V1032793 G bifunctional PTS system fructose-specific transporter subunit IIA HPr protein COG4668 V1032815 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 V1032912 H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) COG0237 V1032923 G had-superfamily hydrolase, subfamily iia COG0647 V1032986 K Protease synthase and sporulation negative regulatory protein pai 1 COG0454 V1032989 E Releases the N-terminal proline from various substrates (By similarity) 0ZVHU V1032998 L DNA protecting protein DprA COG0758 V1033123 F thymidine kinase COG1435 V1033126 P phosphonate ABC transporter, periplasmic phosphonate-binding protein COG3221 V1033128 J Binds to the 23S rRNA (By similarity) COG0359 V1033129 G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) COG1080 V1033142 F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) COG0461 V1033159 J s4 domain protein COG2302 V1033185 M mechanosensitive ion channel COG0668 V1033195 K regulatoR COG2390 V1033254 G phosphoglycerate mutase COG0406 V1033266 E lipolytic protein, gdsl family COG2755 V1033278 F nudix hydrolase COG0494 V1033334 L reverse transcriptase COG3344 V1033438 P ABC superfamily ATP binding cassette transporter ABC protein COG1173 V1033459 E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) COG0289 V1033460 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) COG0329 V1033471 K Transcriptional regulator COG1349 V1033500 G Aldolase COG0191 V1033515 P phosphate COG0226 V1033535 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) COG0669 V1033567 P Plays a role in the regulation of phosphate uptake COG0704 V1033592 U Transport protein ComB 0XX01 V1033599 M Cell wall-associated hydrolase COG0791 V1033606 S phosphorylase 11F11 V1033633 S Lysm domain protein 11U6T V1033636 S Archaeal ATPase 0ZW9J V1033675 C aldo keto reductase COG0656 V1033691 F permease COG2233 V1033753 E Peptidase family M23 11ZGW V1033797 G resistance protein 0XNN3 V1033805 K TRANSCRIPTIONal REGULATOR, LysR family COG0583 V1034200 V ABC transporter, ATP-binding protein COG1136 V1034240 G PTS System COG1264 V1034259 J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) COG0050 V1034284 S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) COG1234 V1034342 S YjcQ protein 0Y2M9 V1047003 S Cbs domain protein COG0517 V1047065 E Peptidase M1 membrane alanine aminopeptidase COG0308 V1047074 G Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) COG3010 V1047082 S Lysm domain protein 11U6T V1047177 G hydrolase family 65, central catalytic COG1554 V1047189 M biosynthesis protein COG3944 V1047242 S ABC-2 type transporter 11FXW V1047269 I Phosphatase COG0671 V1047283 L transposase COG0675 V1101414 M Choloylglycine hydrolase COG3049 V1101444 G phosphoglycerate mutase COG0406 V1101488 L Inherit from COG: transposase COG2826 V1143329 C alcohol dehydrogenase COG1063 V1149288 L Transposase COG3328 V1150386 E, G Transporter COG0697 V1150468 S Inherit from NOG: DNA repair protein 0XQPN V1163025 V aminoglycoside N(3)-acetyltransferase COG2746 V1163852 K GntR family transcriptional regulator COG2188 V1199410 M (sortase) family COG3764 V1204334 O reductase COG0229 V1204586 D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) COG0206 V1204708 G Pts system COG1455 V1204783 E Extracellular solute-binding protein, family 5 COG4166 V1212521 F Probably involved in ribonucleotide reductase function (By similarity) COG1780 V1213966 L Transposase COG3328 V1225059 S NA 0ZHU9 V1237276 S Toprim domain protein 0XSQN V1237371 S surface protein 11NE4 V1300553 C NADH dehydrogenase COG1252 V1366238 M NA 0YESU V1388974 S NA 0Y5Y1 V1389104 L Transposase (IS4 family 11HCS V1500615 S NA 0ZHU9 V1552698 M Glycosyl transferase, family 2 COG1215 V1616067 S Pfam:Transposase_9 0Y2FG V1684153 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 V1796837 P ABC transporter, permease COG2011 V1806646 E permease COG0833 V1808019 S Teichoic acid glycosylation protein COG2246 V1819365 O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) COG5405 V1828846 S NA 0ZQJ3 V1828852 L Transposase COG3328 V1828854 L transposase COG2826 V1872748 V abc transporter atp-binding protein COG1131 V1879922 L transposase COG2826 V1882173 S short-chain dehydrogenase reductase COG0300 V1882982 J -acetyltransferase COG1670 V1883116 T Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) COG1493 V1884646 G sucrose-6-phosphate hydrolase COG1621 V1884783 L Inherit from COG: transposase COG2826 V1885126 L Topoisomerase COG0550 V1886281 S Inherit from COG: Hemerythrin HHE cation binding domain protein COG2461 V1886305 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 V1887156 I Acetyl-CoA acetyltransferase COG0183 V1890869 S MMPL domain protein COG2409 V1890887 U Transport protein ComB 0XX01 V1891117 K Sucrose operon repressor COG1609 V1891128 E, P ABC transporter COG0444 V1891158 V Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) COG1136 V1032234 K transcriptional modulator of maze toxin, mazf 11SRX V1032313 U Preprotein translocase subunit COG1862 V1032319 O Thioredoxin COG0526 V1032320 M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) COG1970 V1032330 H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) COG0301 V1032333 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) COG0522 V1032336 T Universal stress protein COG0589 V1032341 C Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) COG0355 V1032355 F Nucleoside deoxyribosyltransferase COG3613 V1032362 P binding-protein-dependent transport systems inner membrane Component COG1175 V1032390 S Protein of unknown function (DUF1149) COG4835 V1032432 E abc transporter atp-binding protein COG1126 V1032433 E ABC transporter substrate-binding protein COG0834 V1032471 T response regulator COG0745 V1032488 S Hydrolase COG0561 V1032559 S hydrolase COG0561 V1032572 P Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) COG1135 V1032583 E amino acid AbC transporter COG0765 V1032591 E, T (ABC) transporter COG0834 V1032603 G Pts system COG2190 V1032706 I mevalonate kinase COG1577 V1032709 S Hydrolase COG0561 V1032748 I Acyl-transferase COG0204 V1032765 E Aminotransferase COG0436 V1032770 G phosphoglycerate mutase COG0406 V1032778 K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) COG0846 V1032801 J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) COG0594 V1032813 J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) COG0091 V1032832 S Inherit from COG: Membrane COG3601 V1032932 S alpha beta COG0596 V1033005 Q Dithiol-disulfide isomerase COG2761 V1033024 S Modulates RecA activity (By similarity) COG2137 V1033095 J 50S ribosomal protein l17 COG0203 V1033115 M Cell wall-associated hydrolase COG0791 V1033118 S Hydrolase COG0546 V1033133 M Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) COG0275 V1033135 P ABC transporter COG1121 V1033140 P Chloride channel COG0038 V1033154 E maltose O-acetyltransferase COG0110 V1033177 T Transcriptional regulatory protein, C terminal 11FPD V1033209 K lytTr DNA-binding domain protein 0XX0T V1033245 L DNA alkylation repair enzyme COG4912 V1033329 M, U This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) COG0597 V1033330 F formyltetrahydrofolate synthetase COG2759 V1033349 K TRANSCRIPTIONal COG1316 V1033352 S Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) COG0344 V1033491 J Specifically methylates guanosine-37 in various tRNAs (By similarity) COG0336 V1033492 J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) COG0806 V1033533 F, G histidine triad (HIT) protein COG0537 V1033542 F Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) COG0319 V1033581 F deoxynucleoside kinase COG1428 V1033603 S Membrane 12CNP V1033624 S NA 11WFA V1033625 C Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) COG1478 V1033646 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 V1033729 L terminase (Small subunit) COG3747 V1033754 J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) COG0532 V1033763 C Flavodoxin COG0716 V1033810 S Antibiotic biosynthesis monooxygenase 0Y2XH V1033815 K Transcriptional regulator 0Y9V9 V1034190 S SprT-like COG3091 V1034235 S NA 128F1 V1034250 O fes assembly suf system protein COG2151 V1034267 G ABC transporter, ATP-binding protein COG3839 V1034299 S Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity) 124BP V1034326 P transporter, permease 11MR9 V1034328 S Type IV secretion-system coupling protein DNA-binding domain 0YAV5 V1047112 L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 V1047139 S Hypothetical protein (DUF2513) 127R5 V1047166 V restriction modification system DNA specificity domain COG0732 V1047180 K transcriptional modulator of maze toxin, mazf 11SRX V1047215 E Aminopeptidase COG0308 V1047279 K Sucrose operon repressor COG1609 V1047308 S Pfam:Phage_integr_N 0YI69 V1101380 S Predicted membrane protein (DUF2335) COG5346 V1101412 M carboxypeptidase COG1686 V1101441 G Drug resistance transporter EmrB QacA 0XNN3 V1101482 K Transcriptional regulator COG1737 V1101487 M Lyzozyme M1 (1,4-beta-N-acetylmuramidase) COG3757 V1101541 S low temperature requirement protein COG4292 V1143184 S NA 11P5R V1143925 S NA 0ZHU9 V1163634 P permease protein COG1175 V1203291 E amino acid COG0531 V1204805 S CAAX amino terminal protease family 0XW1D V1204821 F Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) COG0127 V1205032 S NA 123QA V1208361 L Transposase COG3328 V1216924 F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) COG0208 V1297823 S NA 0ZHU9 V1300366 S Phage head morphogenesis protein COG2369 V1300551 S NA 0ZHU9 V1366244 I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) COG0736 V1552723 G aldose 1-epimerase COG2017 V1552744 V Beta-lactamase class C related penicillin binding protein COG1680 V1552785 S NA 0XVT8 V1552797 L Transposase COG3436 V1614838 L Transposase COG3328 V1684087 L transposase COG2826 V1684164 K transcriptional regulator 0ZMZA V1755531 L Transposase COG3666 V1796865 S Membrane 11YSX V1796868 P ABC transporter, permease COG0609 V1806575 H riboflavin synthase, subunit alpha COG0307 V1806596 J Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) COG0042 V1806614 S Abortive infection protein AbiGI 11WH3 V1819405 E Dipeptidase COG4690 V1872682 C glycerophosphoryl diester phosphodiesterase COG4781 V1882175 J pseudouridine synthase COG0564 V1883158 L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) COG2255 V1884268 G trehalose-6-phosphate hydrolase (EC 3.2.1.93) COG0366 V1884595 G trehalose-6-phosphate hydrolase (EC 3.2.1.93) COG0366 V1884627 G levansucrase EC 2.4.1.10 0XR0E V1884636 O Thioredoxin reductase COG0492 V1884647 J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) COG0064 V1884649 S Xanthine uracil vitamin C permease COG2252 V1885169 L reverse transcriptase COG3344 V1886055 M Cell wall-associated hydrolase COG0791 V1886353 C fumarate reductase flavoprotein, subunit COG1053 V1887311 S Protein of unknown function (DUF1304) 0XV9E V1891122 S Metallo-Beta-Lactamase COG0595 V1891198 L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) COG0323 V1891259 I diphosphomevalonate decarboxylase COG3407 V1899820 S Lpxtg-motif cell wall anchor domain protein 0Y34J V1032219 T Universal stress protein COG0589 V1032323 F Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) COG0127 V1032327 S GtrA-like protein 0XV3V V1032334 S Protein of unknown function (DUF1694) COG5506 V1032349 F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) COG0035 V1032352 J acetyltransferase, (GNAT) family COG1670 V1032353 S SNARE-like domain protein COG0398 V1032389 J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) COG0219 V1032401 L Inherit from COG: Competence protein COG1040 V1032411 S -acetyltransferase 11PF0 V1032484 J peptide deformylase COG0242 V1032524 L Involved in initiation control of chromosome replication (By similarity) COG4467 V1032553 S protein family UPF0079, ATPase COG0802 V1032575 F Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) COG0207 V1032587 F uridine monophosphokinase COG0572 V1032640 S Required for maturation of 30S ribosomal subunits (By similarity) COG0779 V1032653 S Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) COG1576 V1032668 G, M epimerase dehydratase COG0702 V1032717 F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) COG0756 V1032727 K transcriptional regulator COG1476 V1032777 L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) COG0350 V1032821 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) COG0096 V1032830 F Cytidine monophosphate kinase COG0283 V1032833 J Pseudouridine synthase COG1187 V1032834 K Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) COG1386 V1032886 H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) COG0669 V1032965 G PTS System COG1445 V1033101 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) COG2065 V1033111 T Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) COG1854 V1033149 P Na H antiporter COG0025 V1033151 S Filamentation induced by cAMP protein fic 11MJJ V1033156 S Membrane COG4720 V1033307 S Necessary for normal cell division and for the maintenance of normal septation (By similarity) COG0218 V1033342 S Alkaline-shock protein COG1302 V1033371 S integral membrane protein 121K9 V1033372 S membrAne COG1284 V1033421 L endodeoxyribonuclease RusA COG4570 V1033445 K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) COG0782 V1033469 F deaminase COG2131 V1033519 G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) COG0580 V1033548 E L-serine dehydratase COG1760 V1033561 S UPF0397 protein COG4720 V1033584 C alcohol dehydrogenase COG1063 V1033589 O Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) COG0691 V1033597 S Addiction module antitoxin, RelB DinJ family 0XUTM V1033623 L nudix hydrolase COG0494 V1033639 M Glyco_25 COG3757 V1033714 L reverse transcriptase COG3344 V1033720 U Signal peptidase i COG0681 V1033725 J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) COG2890 V1033728 S Lysm domain protein 11U6T V1033751 L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 V1033770 S Membrane 0XVF5 V1033818 K HTH_XRE COG1974 V1033848 F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) COG0503 V1034203 G phosphoglycerate mutase COG0406 V1034242 P phosphonate ABC transporter, periplasmic phosphonate-binding protein COG3221 V1034273 P Sodium hydrogen exchanger COG0475 V1034301 C reductase COG0656 V1034337 S hicB family COG4226 V1046997 L DNA repair protein (RadC COG2003 V1047026 S NA 0Y5Y1 V1047059 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 V1047160 L Nudix family COG0494 V1047170 L transposase COG0675 V1047194 S NA 0ZWRQ V1047231 S Archaeal ATPase 0ZW9J V1047295 S Pfam:Transposase_9 0Y2FG V1047302 K Transcriptional regulator 0Y1S3 V1101467 V restriction enzyme 17CDW@proNOG V1101530 L Transposase COG3328 V1101548 S hydrolase 0XPIC V1143168 S NA 11YKG V1143236 M NA 0YESU V1143255 S phage Tail Protein 129AY V1143431 V ATP-binding protein COG2274 V1150312 G PTS system mannitol-specific COG2213 V1150391 S hydrolase COG0596 V1150481 S integral membrane protein 11UKN V1162552 K Phage regulatory protein rha COG3646 V1162914 S Xanthine uracil vitamin C permease COG2252 V1163641 S YycH protein COG4863 V1163687 K Transcriptional regulator 120E9 V1163713 I, M Glycerol-3-phosphate cytidylyltransferase COG0615 V1163751 N, O, U Bacterial Peptidase A24 N-terminal domain COG1989 V1163822 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) COG0552 V1163933 K Nucleic-acid-binding protein implicated in transcription termination COG2740 V1200427 L Transposase (IS4 family 11HCS V1202485 G PTS System COG1445 V1202534 E ABC transporter COG0747 V1203933 S Membrane COG0730 V1204551 S NA 122AV V1204595 K acetyltransferase COG0454 V1204734 C Dehydrogenase COG1454 V1204758 K Transcriptional regulator COG1609 V1237097 C Aldo keto reductase COG0656 V1338905 P ABC transporter COG0803 V1446922 E Aspartokinase COG0527 V1503161 S Lpxtg-motif cell wall anchor domain protein 0Y34J V1552703 L Exodeoxyribonuclease III COG0708 V1552731 G extracellular solute-binding protein family 1 COG1653 V1552732 P ABC transporter COG0395 V1552798 K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) COG0568 V1614144 L Inherit from COG: transposase COG2826 V1684101 S Inherit from COG: Tail protein COG5283 V1684120 O Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) COG0760 V1684124 K Transcriptional regulator 0XUC3 V1755520 S Xanthine uracil vitamin C permease COG2252 V1755548 P p-type atpase COG2217 V1796846 V VanZ-like protein COG4767 V1796850 S acidPPc 0XUCW V1796914 L Resolvase COG2452 V1806598 L transposase COG2826 V1806630 S phage protein 11V3M V1806645 G 2-dehydro-3-deoxyphosphogluconate aldolase 4-hydroxy-2-oxoglutarate aldolase COG0800 V1807930 S Pfam:Cw-hydrolase 11PC4 V1808014 G Drug resistance transporter EmrB QacA 0XNN3 V1819370 S NA 101GK V1819374 C, P ABC transporter, permease COG1668 V1828836 M Glyco_25 COG3757 V1828850 F uridine monophosphokinase COG0572 V1828851 K Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity) COG3343 V1828861 S Protein of unknown function (DUF3290) 122B8 V1872681 K transcriptional regulator COG1309 V1879976 L Transposase COG3328 V1880085 O PPIases accelerate the folding of proteins COG0652 V1880096 V restriction modification system DNA specificity domain COG0732 V1880118 M NA 0YESU V1880900 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 V1882381 L transposase COG0675 V1883152 S Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) COG3331 V1883269 E Pfam:DapD_N COG2171 V1883298 L transposase COG2826 V1883308 G converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) COG2017 V1883336 E amino acid COG0531 V1884267 T protein tyrosine serine phosphatase COG2365 V1884496 S integral membrane protein 121K9 V1884517 M Glycosyl transferase, family 4 COG0472 V1884600 E amino acid COG1113 V1884610 P ABC, transporter COG1108 V1884623 E abc transporter atp-binding protein COG1126 V1884681 F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) COG1816 V1884807 L Inherit from COG: transposase COG2826 V1884868 L transposase (IS4 family) protein 0XQ88 V1884873 S Lpxtg-motif cell wall anchor domain protein 0Y34J V1886107 L DNA repair exonuclease COG0420 V1886276 U Competence protein COG1459 V1886312 E ABC transporter COG0747 V1886369 S Xanthine uracil vitamin C permease COG2252 V1886984 P Plays a role in the regulation of phosphate uptake COG0704 V1887283 S Pyridoxamine 5'-phosphate oxidase 11ST5 V1887289 P asch domain protein COG4405 V1890891 L transposase COG0675 V1891105 G ribokinase COG0524 V1891309 S NA 120SA V1032316 L Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) COG0816 V1032317 S UPF0473 protein COG3906 V1032321 S hydrocarbon binding protein 121J8 V1032346 C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) COG0711 V1032377 S Addiction module toxin, Txe YoeB family COG4115 V1032420 S Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) COG0799 V1032459 S Nadph-dependent fmn reductase COG0431 V1032463 S Colicin v production protein 0Y5GJ V1032528 S acetyltransferase COG0456 V1032560 T Low molecular weight phosphotyrosine protein phosphatase COG0394 V1032574 H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) COG0262 V1032592 F Glutamine amido-transferase COG0518 V1032594 G phosphoriboisomerase A COG0120 V1032612 S aggregation promoting protein 0YUHU V1032678 D Septum formation initiator COG2919 V1032704 J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) COG0525 V1032775 S MarR family Transcriptional regulator COG3189 V1032805 S Domain of unknown function (DUF955) 0XW04 V1032807 J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) COG0087 V1032884 S UPF0298 protein COG4471 V1032956 K Transcriptional regulator COG2188 V1033006 S CYTH domain COG4116 V1033027 S YbaK ebsC protein COG2606 V1033035 J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) COG0292 V1033068 S Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) COG1939 V1033090 J 30S ribosomal protein S9 COG0103 V1033091 J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) COG0102 V1033092 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 V1033114 F Guanylate kinase COG0194 V1033141 G, M Nad-dependent epimerase dehydratase COG0702 V1033204 S Addiction module antitoxin, RelB DinJ family 0XUTM V1033206 K Transcriptional regulator 11YEF V1033216 S alkaline shock protein COG1302 V1033234 S phage protein 124IT V1033250 S Veg protein COG4466 V1033252 L Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) COG1658 V1033302 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 V1033305 E ornithine carbamoyltransferase COG0078 V1033333 H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) COG0054 V1033375 O Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation COG0544 V1033379 T Transcriptional regulator, Crp Fnr family COG0664 V1033415 G fructokinase COG1940 V1033416 F Essential for recycling GMP and indirectly, cGMP (By similarity) COG0194 V1033425 S Domain of unknown function (DUF956) COG4687 V1033430 L terminase (Small subunit) COG3728 V1033490 J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) COG0335 V1033536 K Transcriptional regulator COG0583 V1033605 K transcriptional Regulator LysR family 11Z5Z V1033733 O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) COG0740 V1033794 S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) COG1806 V1033849 L DNA topoisomerase IV (Subunit B) COG0187 V1033885 M Cell wall formation (By similarity) COG0773 V1034183 H Metal Dependent Phosphohydrolase COG1713 V1034269 C Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) COG1304 V1034344 S Nitroreductase 1234Z V1047032 S Thioredoxin 0ZB1G V1047336 V ATP-binding protein COG2274 V1101415 S protein (oxidative damage protectant) 11VSY V1101501 M NA 0YESU V1101586 P Plays a role in the regulation of phosphate uptake COG0704 V1143196 S NA 12CJH V1143235 S Domain of unknown function (DUF955) 0XW04 V1143363 K Inherit from firmNOG: Transcriptional regulator COG2865 V1143432 V ATP-binding protein COG2274 V1147284 S NA 0ZHU9 V1150461 S NA 0Y5Y1 V1162936 S NA 11VH8 V1162950 O Thioredoxin reductase COG0492 V1162956 P Transport of potassium into the cell (By similarity) COG3158 V1163104 S decarboxylase COG0599 V1199003 S NA 0ZHU9 V1199358 S Hydrolase COG0561 V1203422 S Lysm domain protein 11U6T V1204036 S integral membrane protein 11UKN V1204412 S relA SpoT domain protein COG2357 V1204481 S NA 0YWIA V1204640 G Alpha-glucosidase COG1501 V1204798 S Lpxtg-motif cell wall anchor domain protein 0Y34J V1204799 S NA 120ST V1204852 F hypoxanthine phosphoribosyltransferase COG0634 V1204942 S Protein of unknown function (DUF2974) 0XSVF V1205802 S NA 0ZHU9 V1206519 F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) COG2065 V1237257 D YhjQ protein COG1192 V1239556 L Transposase COG3464 V1258606 S NA 0ZHU9 V1260295 S NA 0ZHU9 V1301214 S NA 125ZN V1338872 F NrdI protein COG1780 V1338904 S Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) COG0344 V1339026 K Sucrose operon repressor COG1609 V1339051 S SNARE associated Golgi COG0586 V1339078 S integral membrane protein COG3548 V1388957 H synthase COG0142 V1388967 S NA 120ST V1398045 S NA 0ZHU9 V1446913 G converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) COG2017 V1452376 M Glyco_25 COG3757 V1461180 S NA 11UA7 V1605239 S NA 0ZHU9 V1615770 S NA 0ZHU9 V1684089 S NA 11GVV V1684106 S ABC superfamily ATP binding cassette transporter, permease 0YYAC V1684192 S integral membrane protein COG2261 V1755583 E acetolactate synthase COG0028 V1806604 K, T lytTr DNA-binding domain protein COG3279 V1806615 S Hydrolase COG1073 V1806620 S Toxin-antitoxin system, antitoxin component, HicB family COG1598 V1806635 V Endonuclease COG1403 V1806660 S NA 0XTTB V1807923 C reductase COG0656 V1819360 S cell wall surface anchor family protein 0YURI V1819371 S Membrane 0XVF5 V1872734 J This protein binds directly to 23S ribosomal RNA (By similarity) COG0080 V1880918 C trp repressor binding protein COG0716 V1882106 K Transcriptional regulator COG1396 V1882253 O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) COG0459 V1883153 J asparaginyl-tRNA synthetase COG0017 V1883182 P p-type ATPase COG2217 V1883273 M Glyco_25 COG3757 V1883297 L Inherit from COG: transposase COG2826 V1883299 L reverse transcriptase COG3344 V1883312 S Lpxtg-motif cell wall anchor domain protein 0Y34J V1883390 F, J deaminase COG0590 V1884309 S Membrane COG1808 V1884516 L transposase COG2826 V1884535 S ABC transporter, ATP-binding protein COG0488 V1884536 V ABC transporter COG1132 V1884577 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 V1884578 K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) COG0085 V1884593 S Cell wall-active antibiotics response protein (DUF2154) 11V5T V1884603 L integrase family COG0582 V1884614 S surface protein 11NE4 V1884628 S Hydrolase COG0561 V1884644 G hydrolase, family 1 COG2723 V1885082 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) COG1393 V1885167 G PTS System COG1440 V1886277 M Glycosyl transferase, family 4 COG0472 V1886286 L Terminase, large subunit COG4626 V1886288 T response regulator COG0745 V1886290 V Beta-lactamase class C related penicillin binding protein COG1680 V1886371 M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) COG0787 V1887241 I diphosphomevalonate decarboxylase COG3407 V1887282 E amino acid COG0531 V1887290 J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) COG0290 V1887313 J Binds together with S18 to 16S ribosomal RNA (By similarity) COG0360 V1890888 L transposase COG0675 V1891132 S Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) COG3331 V1891142 L transposase IS116 IS110 IS902 family protein COG3547 V1891181 T response regulator COG0745 V1891247 E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) COG0112 V1891413 L Inherit from COG: transposase COG2826 V1032345 C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) COG0712 V1032440 S NA 120SA V1032442 S Uncharacterized protein conserved in bacteria (DUF2184) COG4834 V1032541 S NA 0XUEQ V1032546 S NA 0YZ26 V1032551 L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) COG0692 V1032554 L dna polymerase iii COG0847 V1032568 S phosphate-starvation-inducible protein PsiE COG3223 V1032590 K Transcriptional regulator 0XYJE V1032624 T protein tyrosine serine phosphatase COG2365 V1032658 S (LipO)protein COG3212 V1032669 S Vanz family COG5652 V1032686 S Membrane COG3610 V1032690 S NA 0YPVV V1032780 S UPF0342 protein COG3679 V1032806 K HTH_XRE 0XUC3 V1032812 J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) COG0185 V1032817 J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal COG0186 V1032818 J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) COG0093 V1032835 S reductase 121UC V1032840 P Transcriptional regulator, Spx MgsR family COG1393 V1032844 S Hydrolase COG4814 V1032848 S integral membrane protein COG2261 V1032911 K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) COG1327 V1032969 P copper chaperone COG2608 V1033051 C Covalent carrier of the coenzyme of citrate lyase (By similarity) COG3052 V1033080 S Abortive phage resistance protein 10AS9 V1033087 Q amidohydrolase COG1228 V1033179 S relA SpoT domain protein COG2357 V1033207 V ABC transporter, ATP-binding protein COG1131 V1033241 S Inherit from COG: Protein of unknown function (DUF1093) COG5294 V1033292 S secreted protein containing plastocyanin domain COG4633 V1033312 O Thioredoxin COG0526 V1033345 K, T lytTr DNA-binding domain protein COG3279 V1033353 K Phage antirepressor protein KilAC domain COG3645 V1033354 S NA 0Y4GC V1033376 P DNA protection during starvation protein COG0783 V1033390 S (ABC) transporter COG4152 V1033393 C SUF system FeS assembly protein, NifU family COG0822 V1033449 S hydrolase COG0561 V1033452 S RNA Polymerase 127VD V1033495 S Protein of unknown function (DUF2922) 0XZ4F V1033526 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 V1033541 S gatB Yqey COG1610 V1033611 F hypoxanthine phosphoribosyltransferase COG0634 V1033657 O fes assembly suf system protein COG2151 V1033694 S Gcn5-related n-acetyltransferase 1221G V1033699 P Atpase, p-type (Transporting), had superfamily, subfamily ic COG0474 V1033731 S short-chain dehydrogenase reductase COG0300 V1033732 S Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) COG2739 V1033742 K HTH_XRE 0XUC3 V1033766 L Transposase (IS4 family 11HCS V1033771 I mevalonate kinase COG1577 V1033782 G Pyruvate kinase COG3848 V1033788 S UPF0756 membrane protein COG2707 V1034208 P rhodanese family COG0607 V1034211 E amino acid COG0531 V1034245 S ABC superfamily ATP binding cassette transporter membrane protein COG4721 V1034262 G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) COG0148 V1034332 F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) COG0284 V1034352 N, O, U Bacterial Peptidase A24 N-terminal domain COG1989 V1034355 G isomerase COG0698 V1034376 K AraC family transcriptional regulator COG2207 V1034420 G symporter COG2211 V1036251 S Esterase COG0627 V1046975 M Glyco_25 COG3757 V1047015 S ABC superfamily ATP binding cassette transporter membrane protein COG4721 V1047167 S NA 11GVV V1047214 F Cytidine monophosphate kinase COG0283 V1101404 G Major Facilitator 0ZVCH V1101407 K Transcriptional regulator 0XRI9 V1101409 K acetyltransferase COG0454 V1101410 I hydroxymethylglutaryL-CoA reductase COG1257 V1101420 S MMPL domain protein COG2409 V1101428 C alcohol dehydrogenase COG1063 V1101440 K TRANSCRIPTIONal COG1316 V1101486 E Peptidase M1 membrane alanine aminopeptidase COG0308 V1101561 S NA 0ZHU9 V1143252 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) COG0225 V1143273 S Prophage Lp2 protein 31 0YXG6 V1143470 S NA 1244F V1144619 O Endothelin-converting enzyme 1 COG3590 V1148960 S Protein of unknown function (DUF3737) 0XTHF V1149291 S Membrane Spanning Protein COG1277 V1149355 L transposase (IS4 family) protein 0XQ88 V1150380 S Uncharacterized protein conserved in bacteria (DUF2213) COG3566 V1162579 C Formyl-CoA transferase COG1804 V1162634 O Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) COG2077 V1162941 M phosphoglycerol transferase alkaline phosphatase superfamily protein COG1368 V1163005 E ABC transporter COG3839 V1163597 G Major Facilitator 0ZVV9 V1163606 T Tetracycline resistance protein COG0480 V1163666 S -acetyltransferase 11TPW V1163714 M D-alanyl-lipoteichoic acid biosynthesis protein DltD COG3966 V1163810 K Transcriptional regulator COG3682 V1163970 P Chloride channel COG0038 V1199405 L Transposase COG3328 V1202123 S ABC transporter, ATP-binding protein COG0488 V1202750 C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) COG2352 V1203091 G Glycosyl hydrolase family 1 COG2723 V1203284 M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) COG1589 V1204335 S 5'-phosphate oxidase COG3576 V1204495 T Histidine kinase COG2972 V1204660 F formyltetrahydrofolate synthetase COG2759 V1204760 E Extracellular solute-binding protein, family 5 COG4166 V1204772 G Major Facilitator 0ZVCH V1214754 S NA 0ZHU9 V1214862 S NA 0ZHU9 V1215404 S NA 0ZHU9 V1237114 G PTS system mannitol-specific COG2213 V1237175 F Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) COG0207 V1300693 C reductase COG0656 V1338862 L transposase COG0675 V1338879 V had superfamily (subfamily IIIa) phosphatase COG2179 V1340126 S NA 0ZHU9 V1340761 S NA 0ZHU9 V1383695 L Transposase COG3328 V1388944 P p-type atpase COG2217 V1388945 D Rod shape-determining protein mreb COG1077 V1388984 G Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) COG0063 V1388998 L The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination COG3857 V1389177 S degv family COG1307 V1411616 S NA 0ZHU9 V1421787 S NA 0ZHU9 V1432816 S NA 0ZHU9 V1450201 S NA 0ZHU9 V1458760 S (ABC) transporter COG4619 V1462679 S NA 0ZHU9 V1476352 S NA 0ZHU9 V1501494 S NA 0ZHU9 V1547375 S Lpxtg-motif cell wall anchor domain protein 0Y34J V1552770 H pantothenic acid kinase COG1072 V1552808 O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) COG0225 V1555422 S NA 0ZHU9 V1610066 M NA 0YESU V1610069 J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) COG0097 V1684073 S NA 0Z3UR V1684079 S Cell division protein mraZ COG2001 V1684105 L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) COG3512 V1684114 H dimethylmenaquinone methyltransferase COG0684 V1755526 V ABC, transporter COG4988 V1755533 S NA 10WM6 V1755537 K transcriptional regulator COG1309 V1755587 J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits COG0099 V1796841 G ribokinase COG0524 V1796882 K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) COG0782 V1806625 S Membrane COG0670 V1806638 S head-tail joining protein 0XW7K V1806802 S NA 11NI8 V1807928 S NA 11UA7 V1808011 S integral membrane protein 11UKN V1808078 L Methyltransferase COG4123 V1808174 J Leucyl-tRNA synthetase COG0495 V1808271 F deoxynucleoside kinase COG1428 V1819358 M Glyco_25 COG3757 V1819404 S NA 0XTTB V1828855 M UTP-glucose-1-phosphate uridylyltransferase COG1210 V1828873 S phage tape measure protein COG5283 V1872767 E amino acid AbC transporter COG0765 V1880026 E asparagine synthetase A COG2502 V1880902 L Transposase COG3328 V1882316 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 V1882361 J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) COG0238 V1882867 L Transposase domain (DUF772) COG3666 V1882886 P ATPase, P-type (Transporting), HAD superfamily, subfamily IC COG0474 V1883157 L Transposase domain (DUF772) COG3666 V1883184 V ABC transporter ATP-binding COG1132 V1883330 L Transposase COG3328 V1884246 S NA 123QA V1884398 E ABC transporter COG0834 V1884416 H 6-pyruvoyl-tetrahydropterin synthase COG0720 V1884481 P p-type ATPase COG2217 V1884494 S cell wall surface anchor family protein 0YURI V1884505 S Abortive phage resistance protein 10AS9 V1884507 S Major tail protein 0Y77V V1884518 S ABC transporter COG3845 V1884526 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0588 V1884566 G Aldolase COG0191 V1884575 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) COG0522 V1884596 L single-stranded DNA-binding protein COG0629 V1884604 L Transposase COG3328 V1884606 M polysaccharide biosynthesis protein COG2244 V1884642 E ABC transporter COG0747 V1884819 L Inherit from COG: transposase COG3666 V1884890 I CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) COG4670 V1886037 S NA 12CJH V1886191 L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) COG0556 V1886195 L Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) COG2176 V1886210 D Rod shape-determining protein mreb COG1077 V1886292 S Membrane COG0670 V1886977 S CAAX amino terminal protease family protein 0XUJM V1890844 J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) COG0049 V1890845 L Transposase (IS4 family 11HCS V1890893 S Pfam:Transposase_9 0Y2FG V1890905 L reverse transcriptase COG3344 V1890908 L Transposase 1012J V1891092 S NA 0Y2WH V1891094 L Transposase (IS4 family 11HCS V1891098 L excinuclease COG0178 V1891114 P transporter, permease 11MR9 V1891144 L Inherit from COG: transposase COG3666 V1891149 S acetyltransferase 11P9X V1891170 H thiamine COG1564 V1891177 L Competence protein COG4098 V1891248 J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) COG1186 V1891298 E peptidase M24 COG0006 V1891344 S cell wall surface anchor family protein 0YURI V1891370 C d-lactate dehydrogenase COG1052 V1000526 L helicase COG3973 V1002108 S NA 0ZHU9 V1006073 S NA 0ZHU9 V1032204 K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) COG0782 V1032328 S NA 11GVV V1032373 H Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) COG0236 V1032419 H Metal Dependent Phosphohydrolase COG1713 V1032430 E amino acid AbC transporter COG0765 V1032437 S NA 0XUEQ V1032467 S protein, conserved in bacteria COG4481 V1032637 J Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) COG0858 V1032659 J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) COG0231 V1032661 S Acetyltransferase (GNAT) family COG2153 V1032712 T gaf domain protein COG1956 V1032822 J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) COG0098 V1032921 S NA 11UDD V1032958 S Domain of unknown function (DUF3284) 12C3S V1032979 J This protein binds to 23S rRNA in the presence of protein L20 (By similarity) COG0261 V1033148 S UPF0346 protein COG4479 V1033184 S Methyl-accepting chemotaxis family protein COG4768 V1033214 L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) COG1722 V1033291 S secreted protein containing plastocyanin domain COG4633 V1033339 I 2-Nitropropane dioxygenase COG2070 V1033366 L helicase COG1061 V1033380 S NA 0Z156 V1033408 S appr-1-p processing domain protein COG2110 V1033417 K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) COG1758 V1033483 E Dipeptidase COG4690 V1033514 J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) COG0081 V1033560 U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) COG0201 V1033579 C, P ABC transporter, permease COG1668 V1033583 S UPF0356 protein COG5503 V1033674 S cell wall surface anchor family protein 0YURI V1033686 M penicillin-binding protein COG0768 V1033713 S Gcn5-related n-acetyltransferase 1221G V1033734 K Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) COG1393 V1033739 K TRANSCRIPTIONAl REGULATOR GntR family COG1725 V1033795 L resolvase COG1961 V1033814 G mannose-6-phosphate isomerase COG1482 V1033832 S Gcn5-related n-acetyltransferase 1221G V1033861 P magnesium-translocating p-type atpase COG0474 V1033871 L Integrase COG0582 V1034184 S Transglycosylase SLT domain COG5283 V1034228 L transposase COG0675 V1034257 G ribulose-phosphate 3-epimerase COG0036 V1034319 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 V1034339 S NA 11GVV V1034369 V Abortive infection bacteriophage resistance protein COG4823 V1034371 S UPF0291 protein COG4224 V1034382 G PTS System 126BH V1036154 L DNA topoisomerase IV subunit A COG0188 V1036169 S Protein of unknown function (DUF3027) 11G10 V1036193 P heavy metal translocating p-type ATPase COG2217 V1036268 M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) COG0770 V1036284 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 V1036842 M d-alanyl-d-alanine carboxypeptidase COG2027 V1037283 M glycosyl transferase COG1215 V1038263 I fatty acid synthase COG4982 V1047004 L endonuclease III COG0177 V1047013 G Major Facilitator superfamily 0XQKC V1047117 S VRR-NUC domain protein 0Z445 V1047143 C Flavocytochrome c COG1053 V1047186 J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) COG0101 V1047212 S NA 12BNJ V1047298 L Transposase COG3328 V1047301 S Lpxtg-motif cell wall anchor domain protein 0Y34J V1047419 S NA 0ZHU9 V1075504 S NA 0ZHU9 V1101376 K ArsR family transcriptional regulator 0XUQV V1101464 S Toxin-antitoxin system, toxin component, RelE family COG4679 V1101494 G resistance protein 0XNN3 V1143186 P phosphonate abc transporter COG3639 V1143648 L transposase COG2826 V1149023 L phage plasmid primase, p4 family COG4983 V1149101 L integrase family COG0582 V1150381 M NA 0YESU V1150389 H Polyprenyl synthetase COG0142 V1150571 L transposase COG2826 V1152223 S NA 0ZHU9 V1162351 S NA 0ZHU9 V1162549 K HTH_XRE 0ZTKP V1162550 S NA 0ZEH5 V1162913 E, G Transporter COG0697 V1162940 K TRANSCRIPTIONAl REGULATOR GntR family COG1725 V1162992 V ABC transporter COG1132 V1163000 S degv family COG1307 V1163037 J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) COG0013 V1163106 V (ABC) transporter COG2274 V1163142 G phosphoriboisomerase A COG0120 V1163177 F nucleoside hydrolase COG1957 V1163649 T Universal stress protein COG0589 V1163654 J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) COG0143 V1163708 S Hydrolase COG0561 V1163740 M udp-glucose 4-epimerase COG1087 V1163742 K transcriptional regulator COG1309 V1163894 P magnesium-translocating p-type atpase COG0474 V1164155 L Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) COG0116 V1164166 E, T (ABC) transporter COG0834 V1164312 E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 V1164504 S acetyltransferase COG4552 V1184071 S NA 0ZHU9 V1199398 S MgtC SapB transporter COG1285 V1199409 P phosphonate ABC transporter, periplasmic phosphonate-binding protein COG3221 V1199571 S NA 0ZHU9 V1200505 S NA 0ZHU9 V1202395 S NA 0ZHU9 V1202532 S Lpxtg-motif cell wall anchor domain protein 0Y34J V1202585 L transposase COG0675 V1202802 L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) COG0178 V1202803 F deoxynucleoside kinase COG1428 V1202852 E ABC transporter COG0747 V1203302 P Chloride channel COG0038 V1204455 S NA 0XVT8 V1204510 G PTS System COG2893 V1204605 L May be involved in recombinational repair of damaged DNA (By similarity) COG0497 V1204692 S Hydrolase COG0561 V1204706 S ATP GTP Binding Protein 0XQ3U V1204756 L Transposase COG3464 V1204781 G Major Facilitator superfamily 0XQKC V1204785 G oxidoreductase COG0673 V1204810 S Protein of unknown function (DUF805) 0ZYU9 V1204829 I CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) COG4670 V1204833 P ABC transporter COG0395 V1205544 V ATP-binding protein COG2274 V1207157 L Transposase COG3328 V1211458 L Transposase COG3328 V1211990 S NA 0ZHU9 V1213993 S NA 0ZHU9 V1223639 L Transposase (IS4 family 11HCS V1232179 O peptidase S8 and S53, subtilisin, kexin, sedolisin COG1404 V1237096 E aminopeptidase c COG3579 V1237881 S NA 0ZHU9 V1239700 K TRANSCRIPTIONal COG1316 V1240287 S NA 0ZHU9 V1292497 S NA 0ZHU9 V1323698 S NA 0ZWRQ V1324544 M Glyco_25 COG3757 V1327189 S NA 1244F V1336073 K transcriptional regulator DeoR family COG1349 V1336805 S NA 0ZHU9 V1336855 S NA 0ZHU9 V1338903 K Inherit from firmNOG: Transcriptional regulator COG2865 V1339040 O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) COG0652 V1339074 E Threonine synthase COG0498 V1359396 S NA 0ZHU9 V1362785 G solute-binding protein COG1653 V1374569 L DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) COG0187 V1387400 S NA 0ZHU9 V1388960 S ABC transporter, permease COG4120 V1412560 S NA 0ZHU9 V1414442 S NA 0ZHU9 V1418942 S NA 0ZHU9 V1432582 P phosphate abc transporter COG0581 V1445267 I synthase COG4982 V1449263 S NA 0ZHU9 V1450545 S NA 0ZHU9 V1453879 S Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) COG0486 V1461576 S NA 0ZHU9 V1486311 S domain protein 0XPXI V1507971 M Sortase family COG3764 V1513840 G hydrolase, family 31 COG1501 V1538066 C subunit L COG1009 V1552710 O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) COG0234 V1552713 G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) COG1109 V1552780 D Essential cell division protein (By similarity) COG4839 V1552829 P Chloride channel COG0038 V1576114 S Cell surface protein 0ZXQA V1598242 S -acetyltransferase 11PF0 V1607305 L Transposase COG3328 V1608682 K AntA/AntB antirepressor COG3645 V1612410 S NA 0ZHU9 V1684076 J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) COG0242 V1684081 S Could be involved in insertion of integral membrane proteins into the membrane (By similarity) COG0759 V1684097 S NA 123QA V1684116 U Preprotein translocase subunit SecG 129R8 V1704981 P ABC transporter, permease COG1175 V1755517 S scp-like extracellular COG2340 V1755518 L Integrase COG0582 V1755570 C L-lactate COG1620 V1755573 S NA 0YPVV V1755576 L Inherit from COG: transposase COG3666 V1755581 S acetyltransferase COG0110 V1806652 S NA 0Z8F5 V1807975 L Transposase COG2801 V1808020 K Transcriptional regulator 0Y1S3 V1808042 S (ABC) transporter COG0488 V1808043 S integral membrane protein COG3548 V1808053 P Na H antiporter COG0025 V1808209 M biosynthesis protein COG3944 V1808213 E Oligoendopeptidase f COG1164 V1808254 K Transcriptional regulator 0Y1S3 V1808267 E amino acid COG0531 V1819411 E Aminotransferase COG0436 V1828881 U Transport protein ComB 0XX01 V1872727 S Putative amino acid metabolism 122BZ V1872728 S Domain of unknown function (DUF1827) 0XV2U V1879979 L transposase COG0675 V1880035 E, G Transporter COG0697 V1880092 V abc transporter atp-binding protein COG1131 V1880862 G mannose-6-phosphate isomerase COG1482 V1880912 G Phosphoketolase COG3957 V1880920 Q isochorismatase COG1335 V1882174 J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) COG0290 V1882178 G Drug resistance transporter EmrB QacA 0XNN3 V1882328 G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) COG0588 V1882856 S Caulimovirus viroplasmin COG3341 V1882892 S -acetyltransferase 11TPW V1882897 H thiamine COG1564 V1882928 L transposase COG0675 V1883165 P p-type atpase COG2217 V1883166 P heavy metal translocating p-type ATPase COG2217 V1883249 F Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) COG0503 V1883294 L Transposase 1012J V1883310 L Transposase (IS4 family 11HCS V1883381 E Cleaves the N-terminal amino acid of tripeptides (By similarity) COG2195 V1884407 S Xanthine uracil vitamin C permease COG2252 V1884409 S degv family COG1307 V1884480 S integral membrane protein COG0392 V1884560 J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) COG0197 V1884583 M Cell wall-associated hydrolase COG0791 V1884585 K Transcriptional regulator 0Y1S3 V1884605 M Glyco_25 COG3757 V1884625 T Histidine kinase COG2972 V1884674 E ABC transporter COG0747 V1884782 L Inherit from COG: transposase COG2826 V1884803 S Hydrolase COG1073 V1884849 M NA 0YESU V1884871 L transposase (IS4 family) protein 0XQ88 V1884896 S Lysm domain protein 11U6T V1885047 C FAD linked oxidase domain protein COG0277 V1885085 S Acyltransferase family 11SJZ V1886028 L IS66 Orf2 family protein COG3436 V1886034 G Glycosyl hydrolase family 1 COG2723 V1886047 G phosphoriboisomerase A COG0120 V1886098 S Metallo-Beta-Lactamase COG0595 V1886121 E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) COG0329 V1886139 M phosphoglycerol transferase alkaline phosphatase superfamily protein COG1368 V1886180 M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) COG1207 V1886183 C cytochrome d ubiquinol oxidase, subunit ii COG1294 V1886234 S NA 11UKT V1886250 T Histidine kinase COG0642 V1886265 V type I restriction enzyme EcoKI subunit R COG4096 V1886275 U Competence protein COG1459 V1886289 S Lysm domain protein 11U6T V1886310 F Glutamine amido-transferase COG0518 V1886935 L transposase COG2826 V1886997 S Bacterial low temperature requirement A protein (LtrA) COG4292 V1887199 O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) COG0533 V1887212 U Signal peptidase i COG0681 V1887297 V Beta-lactamase class C related penicillin binding protein COG1680 V1887317 S Inherit from COG: Hemerythrin HHE cation binding domain protein COG2461 V1887319 Q amidohydrolase COG1228 V1890865 L Transposase COG3328 V1890900 S NA 12840 V1890948 L Transposase COG3328 V1891192 J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0090 V1891205 S ABC transporter, permease COG4120 V1891244 S Competence protein COG2333 V1891250 E ABC transporter COG0747 V1891251 U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0541 V1891253 P pyridine nucleotide-disulfide oxidoreductase COG0446 V1891260 I mevalonate kinase COG1577 V1891305 G Major Facilitator 0XPHU