Sample Annotation numGene numReads test NA 204 2189 test ABC transporter 62 1425 test Transposase 61 2679 test Transcriptional regulator 52 877 test transposase 33 376 test Membrane 30 594 test amino acid 26 580 test Hydrolase 21 280 test ABC transporter, ATP-binding protein 19 352 test Inherit from COG: transposase 19 555 test integral membrane protein 19 213 test ABC transporter, permease 18 279 test Major Facilitator 17 315 test (ABC) transporter 16 410 test Glyco_25 16 173 test Lpxtg-motif cell wall anchor domain protein 16 260 test Transposase (IS4 family 15 320 test transcriptional regulator 15 260 test Histidine kinase 14 427 test PTS System 13 211 test Integrase 11 235 test Competence protein 10 208 test DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) 10 259 test abc transporter atp-binding protein 10 156 test response regulator 10 167 test Transporter 9 147 test phosphoglycerate mutase 9 106 test transposase (IS4 family) protein 9 494 test Dehydrogenase 8 142 test Extracellular solute-binding protein, family 5 8 259 test Lysm domain protein 8 67 test Xanthine uracil vitamin C permease 8 115 test domain protein 8 232 test helicase 8 207 test hydrolase 8 102 test pts system 8 298 test reductase 8 99 test reverse transcriptase 8 63 test transposase IS116 IS110 IS902 family protein 8 492 test Cell wall-associated hydrolase 7 77 test Dipeptidase 7 207 test Drug resistance transporter EmrB QacA 7 140 test Glycosyl transferase, family 2 7 182 test Na H antiporter 7 120 test Phosphoketolase 7 155 test TRANSCRIPTIONal 7 179 test acetyltransferase 7 66 test degv family 7 86 test penicillin-binding protein 7 239 test surface protein 7 174 test -acetyltransferase 6 49 test ABC, transporter 6 123 test ATP-binding protein 6 192 test Chloride channel 6 93 test DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) 6 144 test HTH_XRE 6 47 test Metallo-Beta-Lactamase 6 129 test Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) 6 117 test Transport of potassium into the cell (By similarity) 6 107 test aminopeptidase c 6 155 test cell wall surface anchor family protein 6 28 test permease 6 104 test transporter 6 127 test trehalose-6-phosphate hydrolase (EC 3.2.1.93) 6 117 test Archaeal ATPase 5 105 test Beta-lactamase class C related penicillin binding protein 5 53 test CAAX amino terminal protease family 5 60 test Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) 5 42 test Glycosyl Transferase 5 111 test Inherit from firmNOG: Transcriptional regulator 5 75 test Metal Dependent Phosphohydrolase 5 55 test One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity 5 27 test Outer surface protein 5 104 test decarboxylase 5 81 test glycerophosphoryl diester phosphodiesterase 5 102 test mannose-6-phosphate isomerase 5 42 test polysaccharide biosynthesis protein 5 163 test protein tyrosine serine phosphatase 5 59 test (LipO)protein 4 50 test Aminotransferase 4 93 test Beta-lactamase 4 94 test CAAX amino terminal protease family protein 4 44 test Cell wall formation (By similarity) 4 93 test Cleaves the N-terminal amino acid of tripeptides (By similarity) 4 48 test Cysteine desulfurase 4 71 test Flavocytochrome c 4 73 test Gcn5-related n-acetyltransferase 4 19 test Glycogen debranching enzyme 4 73 test Glycosyl transferase, family 4 4 36 test Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY 4 32 test MMPL domain protein 4 119 test Major Facilitator superfamily 4 30 test May be involved in recombinational repair of damaged DNA (By similarity) 4 43 test Nudix family 4 34 test Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) 4 26 test Pyruvate kinase 4 29 test ROK family 4 57 test Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) 4 45 test Rib/alpha-like repeat 4 107 test Rod shape-determining protein mreb 4 52 test Tetracycline resistance protein 4 88 test Threonine synthase 4 34 test Transport protein ComB 4 44 test Uncharacterized protein conserved in bacteria (DUF2213) 4 48 test acetolactate synthase 4 53 test amino acid AbC transporter 4 39 test amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) 4 91 test beta-galactosidase 4 100 test deoxynucleoside kinase 4 35 test fes assembly suf system protein 4 32 test heavy metal translocating p-type ATPase 4 73 test lytTr DNA-binding domain protein 4 34 test magnesium-translocating p-type atpase 4 152 test nucleoside hydrolase 4 65 test oxidoreductase 4 114 test p-type ATPase 4 80 test p-type atpase 4 44 test phage protein 4 73 test phosphoglycerol transferase alkaline phosphatase superfamily protein 4 105 test phosphonate ABC transporter, periplasmic phosphonate-binding protein 4 49 test phosphonate abc transporter 4 69 test phosphoriboisomerase A 4 46 test resistance protein 4 27 test sucrose-6-phosphate hydrolase 4 35 test terminase (Small subunit) 4 40 test transcriptional modulator of maze toxin, mazf 4 28 test 1,4-dihydroxy-2-naphthoate octaprenyltransferase 3 81 test ABC superfamily ATP binding cassette transporter ABC protein 3 46 test ABC superfamily ATP binding cassette transporter membrane protein 3 37 test ABC superfamily ATP binding cassette transporter, permease 3 57 test ABC transporter substrate-binding protein 3 47 test ATP-dependent Clp protease, proteolytic subunit 3 38 test ATPase (AAA 3 143 test Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) 3 68 test Addiction module antitoxin, RelB DinJ family 3 19 test Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) 3 40 test Alpha-glucosidase 3 80 test AntA/AntB antirepressor 3 39 test Aspartokinase 3 57 test Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) 3 32 test Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) 3 13 test CBS domain protein 3 57 test Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) 3 28 test Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) 3 42 test Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) 3 84 test Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) 3 19 test Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) 3 45 test Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) 3 51 test Cell surface protein 3 45 test CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) 3 36 test Domain of unknown function (DUF955) 3 33 test Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) 3 17 test Endothelin-converting enzyme 1 3 112 test ErfK YbiS YcfS YnhG 3 92 test F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) 3 11 test Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) 3 12 test General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) 3 61 test Inherit from COG: Tail protein 3 365 test Inherit from NOG: DNA repair protein 3 50 test Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) 3 26 test Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) 3 31 test Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) 3 64 test L-lactate 3 75 test Lanthionine synthetase C family protein 3 45 test Leucyl-tRNA synthetase 3 59 test Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) 3 27 test Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) 3 17 test Oligoendopeptidase f 3 33 test PTS system mannitol-specific 3 40 test Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) 3 68 test Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) 3 76 test Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) 3 55 test Pfam:Transposase_8 3 164 test Pfam:Transposase_9 3 26 test Phage Portal Protein 3 44 test Phage antirepressor protein KilAC domain 3 28 test Phosphoribosyl pyrophosphate synthase 3 46 test Plays a role in the regulation of phosphate uptake 3 29 test Protein of unknown function (DUF2974) 3 82 test Protein of unknown function (DUF3383) 3 67 test Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) 3 18 test Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) 3 25 test Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) 3 108 test Signal peptidase i 3 37 test Single-stranded-DNA-specific exonuclease (RecJ) 3 58 test Sodium hydrogen exchanger 3 69 test Sucrose operon repressor 3 32 test TRANSCRIPTIONAl REGULATOR GntR family 3 28 test Terminase, large subunit 3 88 test The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) 3 65 test The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) 3 41 test Thioredoxin 3 25 test This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) 3 20 test Transglycosylase SLT domain 3 99 test Universal stress protein 3 20 test abc transporter 3 35 test abc transporter permease protein 3 115 test alcohol dehydrogenase 3 33 test alpha beta 3 54 test amidohydrolase 3 27 test amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) 3 62 test basic membrane 3 50 test carbamoyl-phosphate synthetase ammonia chain 3 158 test cytochrome d ubiquinol oxidase, subunit ii 3 24 test dna polymerase iii 3 59 test esterase 3 64 test folylpolyglutamate synthase Dihydrofolate synthase 3 38 test gtp-binding protein 3 25 test it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) 3 54 test mevalonate kinase 3 21 test muts2 protein 3 100 test pantothenic acid kinase 3 51 test peptidase M24 3 64 test permease protein 3 50 test phage tape measure protein 3 36 test phosphate abc transporter 3 65 test pyridine nucleotide-disulfide oxidoreductase 3 40 test restriction modification system DNA specificity domain 3 25 test ribonuclease 3 6 test serine threonine protein phosphatase 3 65 test synthase 3 34 test (P-type) ATPase 2 64 test (Ubiquinol oxidase) subunit I 2 132 test (sortase) family 2 15 test 6-phospho-beta-glucosidase (EC 3.2.1.86) 2 54 test ABC transporter (Permease 2 63 test ABC transporter ATP-binding 2 52 test ABC transporter transmembrane region 2 45 test ATP GTP Binding Protein 2 31 test ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates 2 48 test ATP-dependent DNA helicase pcra 2 54 test ATP-dependent RNA helicase 2 53 test Abi-like protein 2 58 test Abortive infection bacteriophage resistance protein 2 44 test Abortive infection protein 2 21 test Abortive phage resistance protein 2 12 test Acetyl-CoA acetyltransferase 2 39 test Acyl-transferase 2 43 test Adenine-specific 2 61 test Aldolase 2 21 test Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) 2 42 test Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) 2 18 test Aminopeptidase 2 96 test Antibiotic biosynthesis monooxygenase 2 28 test Arginyl-tRNA synthetase 2 48 test Atpase, p-type (Transporting), had superfamily, subfamily ic 2 7 test Bacterial Peptidase A24 N-terminal domain 2 16 test Bacteriophage protein 2 45 test Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) 2 10 test Binding-protein-dependent transport systems inner membrane component 2 4 test Binding-protein-dependent transport systems, inner membrane component 2 53 test Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) 2 16 test Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) 2 5 test Binds to the 23S rRNA (By similarity) 2 26 test Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) 2 25 test Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) 2 17 test Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) 2 61 test Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) 2 49 test Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) 2 55 test Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) 2 15 test Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) 2 32 test Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) 2 13 test Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) 2 13 test Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) 2 74 test Catalyzes the formation of S-adenosylmethionine from methionine and ATP 2 29 test Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) 2 38 test Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) 2 59 test Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) 2 38 test Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) 2 52 test Catalyzes the synthesis of GMP from XMP (By similarity) 2 45 test Caulimovirus viroplasmin 2 21 test Cbs domain protein 2 36 test Cell division protein mraZ 2 10 test Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) 2 23 test Cell wall-active antibiotics response protein (DUF2154) 2 25 test Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) 2 14 test Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) 2 10 test Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) 2 15 test Cytidine monophosphate kinase 2 13 test D-alanyl-lipoteichoic acid biosynthesis protein DltD 2 41 test DNA polymerase iii 2 28 test DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) 2 39 test DNA repair exonuclease 2 28 test DNA topoisomerase IV (Subunit B) 2 50 test Diacylglycerol kinase 2 46 test Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) 2 26 test Endonuclease 2 23 test Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) 2 43 test Esterase 2 6 test Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) 2 60 test Filamentation induced by cAMP protein fic 2 9 test Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) 2 82 test Formyl-CoA transferase 2 45 test GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) 2 38 test GlcNAc 6-P deacetylase 2 70 test Gluconate kinase 2 39 test Glutamine amido-transferase 2 13 test Glutamine amidotransferase 2 52 test Glyceraldehyde-3-phosphate dehydrogenase 2 34 test Glycosyl hydrolase family 1 2 7 test Glycosyl transferase (Group 1 2 74 test Glycosyl transferase family 8 2 61 test Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) 2 14 test Hypothetical protein (DUF2513) 2 13 test IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) 2 10 test In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) 2 39 test Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) 2 35 test Inherit from COG: Hemerythrin HHE cation binding domain protein 2 17 test Inherit from COG: amidohydrolase 2 38 test Inherit from COG: type IV secretion system protein 2 50 test Inner membrane transporter yjeM 2 67 test Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) 2 9 test Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) 2 45 test Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation 2 26 test Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) 2 7 test L-lactate dehydrogenase 2 47 test Lipoprotein 2 48 test Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) 2 9 test Major tail protein 2 25 test Membrane Spanning Protein 2 21 test Methyltransferase 2 17 test MgtC SapB transporter 2 18 test Myosin-Cross-Reactive Antigen 2 84 test NADH dehydrogenase 2 31 test Nad-dependent epimerase dehydratase 2 25 test Nadph-dependent fmn reductase 2 20 test Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) 2 24 test Nitroreductase 2 21 test Nucleoside deoxyribosyltransferase 2 30 test Oligopeptide ABC transporter, permease protein AppB 2 23 test One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) 2 76 test One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) 2 13 test One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) 2 16 test Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) 2 47 test Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) 2 74 test Peptidase M1 membrane alanine aminopeptidase 2 21 test Peptidase family M23 2 26 test Phage head morphogenesis protein 2 28 test Phage-associated protein, HI1409 family 2 65 test Phosphatase 2 12 test Phosphoglycerate kinase 2 39 test Phosphomevalonate kinase 2 32 test Polyprenyl synthetase 2 29 test Polysaccharide biosynthesis protein 2 67 test Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) 2 29 test Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) 2 45 test Prophage Lp1 protein 65 2 32 test Protein of unknown function (DUF3737) 2 19 test Protein of unknown function (DUF805) 2 25 test Pseudouridine synthase 2 24 test Pts system 2 21 test Pyridoxamine 5'-phosphate oxidase 2 12 test RNA Polymerase 2 19 test Releases the N-terminal proline from various substrates (By similarity) 2 31 test Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) 2 19 test Replicative dna helicase 2 35 test Resolvase 2 28 test Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) 2 19 test SAM-dependent methyltransferase 2 39 test Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) 2 24 test Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) 2 43 test Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) 2 20 test Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) 2 23 test Sulfatase 2 102 test The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) 2 27 test The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) 2 20 test The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination 2 87 test The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation 2 61 test Thioredoxin reductase 2 19 test This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits 2 20 test This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) 2 6 test This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) 2 59 test Topoisomerase 2 54 test Toprim domain protein 2 13 test Transcriptional regulator, ARAC family 2 19 test Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) 2 16 test Transposase domain (DUF772) 2 9 test Type IV secretion-system coupling protein DNA-binding domain 2 44 test UTP-glucose-1-phosphate uridylyltransferase 2 38 test Uncharacterized conserved protein (DUF2075) 2 49 test Uncharacterized protein conserved in bacteria (DUF2184) 2 23 test acidPPc 2 29 test adenylosuccinate lyase 2 38 test aldo keto reductase 2 19 test aldose 1-epimerase 2 28 test aluminum resistance protein 2 51 test asparagine synthetase 2 61 test asparagine synthetase A 2 25 test asparaginyl-tRNA synthetase 2 30 test biosynthesis protein 2 15 test branched-chain amino acid transport system II carrier protein 2 44 test carbamoyl-phosphate synthetase glutamine chain 2 50 test carboxypeptidase 2 55 test cation-transporting atpase 2 134 test cell division protein 2 62 test converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) 2 18 test crispr-associated protein 2 54 test d-lactate dehydrogenase 2 32 test damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) 2 50 test deaminase 2 20 test defense response to bacterium 2 19 test dimethylmenaquinone methyltransferase 2 6 test diphosphomevalonate decarboxylase 2 20 test dna polymerase I 2 69 test epimerase dehydratase 2 12 test excinuclease 2 31 test extracellular solute-binding protein family 1 2 33 test formyltetrahydrofolate synthetase 2 18 test fructokinase 2 25 test fumarate reductase flavoprotein, subunit 2 45 test glutamine synthetase 2 34 test glycoside hydrolase family protein 2 173 test gtp-binding protein typa 2 57 test hemerythrin hhe cation binding domain protein 2 32 test hemolysin iii 2 20 test hydrolase family 65, central catalytic 2 64 test hydrolase, family 8 2 78 test hypoxanthine phosphoribosyltransferase 2 16 test integrase family 2 14 test isomerase 2 15 test it plays a direct role in the translocation of protons across the membrane (By similarity) 2 16 test levansucrase EC 2.4.1.10 2 64 test lipolytic protein, gdsl family 2 16 test lysyL-tRNA synthetase 2 45 test methyltransferase 2 18 test modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) 2 53 test nudix hydrolase 2 22 test ornithine carbamoyltransferase 2 23 test peptidase S8 and S53, subtilisin, kexin, sedolisin 2 6 test peptidase, M16 2 66 test phage major capsid protein, HK97 family 2 78 test phage plasmid primase, p4 family 2 65 test phage tail tape measure protein 2 97 test phenylalanyl-tRNA synthetase (beta subunit) 2 59 test phosphate 2 37 test phosphomethylpyrimidine kinase 2 23 test phosphorylase 2 29 test pseudouridine synthase 2 30 test recombination factor protein RarA 2 43 test regulatoR 2 35 test regulator 2 18 test relA SpoT domain protein 2 9 test resolvase 2 5 test ribokinase 2 20 test ribosome biogenesis GTPase YqeH 2 42 test s4 domain protein 2 14 test secreted protein containing plastocyanin domain 2 9 test serine threonine protein kinase 2 50 test short-chain dehydrogenase reductase 2 25 test subunit L 2 5 test symporter 2 65 test tail component 2 48 test thiamine 2 7 test transcriptional Regulator LysR family 2 28 test transcriptional regulator DeoR family 2 21 test transcriptional regulator, lysR family 2 34 test transporter, permease 2 19 test type I restriction enzyme EcoKI subunit R 2 86 test type I restriction-modification system 2 41 test udp-glucose 4-epimerase 2 32 test uridine monophosphokinase 2 13 test uridylyltransferase 2 59 test ybbr family 2 25 test (Anaerobic) ribonucleoside-triphosphate reductase 1 66 test (GntR family) (Transcriptional regulator 1 19 test (citrate (pro-3S)-lyase ligase 1 30 test 2',3'-cyclic-nucleotide 2'-phosphodiesterase EC 3.1.4.16 1 30 test 2'-3'-cyclic nucleotide 1 17 test 2-Nitropropane dioxygenase 1 5 test 2-dehydro-3-deoxyphosphogluconate aldolase 4-hydroxy-2-oxoglutarate aldolase 1 9 test 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) 1 48 test 3-methyladenine DNA glycosylase 1 18 test 30S ribosomal protein S1 1 14 test 30S ribosomal protein S2 1 19 test 30S ribosomal protein S21 1 2 test 30S ribosomal protein S9 1 6 test 4-alpha-glucanotransferase 1 3 test 5'-nucleotidase 1 39 test 5'-phosphate oxidase 1 6 test 5-formyltetrahydrofolate cyclo-ligase 1 17 test 50S ribosomal protein l17 1 11 test 50S ribosomal protein l27 1 2 test 50S ribosomal protein l28 1 2 test 50s ribosomal protein L10 1 14 test 6-phosphogluconolactonase (EC 3.1.1.31) 1 18 test 6-pyruvoyl-tetrahydropterin synthase 1 6 test ABC transporter (Permease) 1 23 test ABC transporter (permease) 1 33 test ABC-2 type transporter 1 15 test ADP-ribosylation crystallin J1 1 2 test ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) 1 34 test ATP-dependent CLP protease ATP-binding subunit 1 49 test ATP-dependent Clp protease ATP-binding subunit 1 54 test ATP-dependent DNA helicase RecG 1 2 test ATP-dependent DNA helicase RecQ 1 28 test ATP-dependent DNA helicase recG 1 49 test ATP-dependent clp protease, ATP-binding subunit 1 67 test ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) 1 24 test ATP-grasp 1 36 test ATPase AAA superfamily 1 30 test ATPase, P-type (Transporting), HAD superfamily, subfamily IC 1 6 test Abortive infection protein AbiGI 1 12 test Abortive infection protein AbiGII 1 34 test Acetylornithine deacetylase 1 18 test Acetyltransferase (GNAT) family 1 7 test Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) 1 18 test Acts as a chaperone (By similarity) 1 42 test Acyl-ACP thioesterase 1 21 test Acylphosphatase 1 2 test Acyltransferase family 1 2 test Addiction module toxin, Txe YoeB family 1 6 test Aldo Keto reductase 1 25 test Aldo keto reductase 1 9 test Alkaline-shock protein 1 9 test Aminotransferase class I and II 1 32 test An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) 1 10 test An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) 1 18 test An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control 1 20 test AraC family transcriptional regulator 1 4 test Arginine dihydrolase 1 23 test ArsR family transcriptional regulator 1 5 test Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) 1 4 test Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) 1 17 test Bacterial extracellular solute-binding proteins, family 5 Middle 1 2 test Bacterial low temperature requirement A protein (LtrA) 1 4 test Bacterial protein of unknown function (DUF910) 1 5 test BadF BadG BcrA BcrD 1 21 test Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) 1 5 test Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) 1 8 test Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) 1 18 test Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) 1 4 test Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) 1 3 test Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) 1 2 test Binds together with S18 to 16S ribosomal RNA (By similarity) 1 9 test CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) 1 26 test CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) 1 5 test CYTH domain 1 8 test Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) 1 21 test Capsular exopolysaccharide family 1 26 test Capsular polysaccharide biosynthesis protein 1 2 test Capsular polysaccharide synthesis protein 1 33 test Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) 1 10 test Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) 1 23 test Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) 1 23 test Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) 1 38 test Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) 1 26 test Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity) 1 12 test Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) 1 53 test Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate 1 24 test Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) 1 48 test Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) 1 34 test Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) 1 51 test Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate (By similarity) 1 21 test Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) 1 17 test Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) 1 15 test Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) 1 22 test Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate (By similarity) 1 29 test Catalyzes the conversion of dihydroorotate to orotate (By similarity) 1 19 test Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) 1 28 test Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) 1 11 test Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity) 1 10 test Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) 1 64 test Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) 1 27 test Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) 1 5 test Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) 1 16 test Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) 1 2 test Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) 1 22 test Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) 1 29 test Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) 1 25 test Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) 1 55 test Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) 1 21 test Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) 1 51 test Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) 1 15 test Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) 1 13 test Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) 1 20 test Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) 1 29 test Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) 1 18 test Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) 1 23 test Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) 1 17 test Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) 1 13 test Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) 1 26 test Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) 1 12 test Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) 1 31 test Cation-transporting atpase 1 52 test Cell division protein DIVIVA 1 2 test Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) 1 2 test Cell wall anchor domain protein 1 2 test Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) 1 28 test Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) 1 35 test Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) 1 19 test Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) 1 13 test Choloylglycine hydrolase 1 10 test Chromosome Partitioning Protein 1 24 test Citrate lyase beta 1 20 test Cobalt transport protein 1 18 test Cold shock protein 1 2 test Colicin v production protein 1 12 test Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) 1 4 test Conserved Protein 1 39 test Conserved hypothetical protein 698 1 24 test Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) 1 12 test Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) 1 21 test Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) 1 9 test Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) 1 8 test Could be involved in insertion of integral membrane proteins into the membrane (By similarity) 1 4 test Covalent carrier of the coenzyme of citrate lyase (By similarity) 1 4 test Cytochrome b5 1 4 test DEAD DEAH box helicase 1 41 test DNA alkylation repair enzyme 1 13 test DNA helicase 1 114 test DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) 1 58 test DNA polymerase III (alpha subunit) 1 68 test DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) 1 50 test DNA polymerase iii, delta' subunit 1 19 test DNA protecting protein DprA 1 13 test DNA protection during starvation protein 1 7 test DNA repair protein (RadC 1 14 test DNA replication protein DnaD 1 15 test DNA topoisomerase IV subunit A 1 2 test DNA topoisomerase IV, subunit A 1 69 test DNA-entry nuclease 1 19 test Death-On-Curing Family 1 10 test Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) 1 3 test Diguanylate cyclase 1 55 test Displays ATPase and GTPase activities (By similarity) 1 33 test Dithiol-disulfide isomerase 1 13 test DivIVA protein 1 23 test Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) 1 3 test Dna-3-methyladenine glycosylase i 1 12 test Domain of unknown function (DUF1827) 1 3 test Domain of unknown function (DUF3284) 1 5 test Domain of unknown function (DUF956) 1 7 test Elongation factor Tu GTP binding domain 1 2 test Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis 1 15 test Endonuclease Exonuclease phosphatase 1 11 test Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) 1 19 test Endoribonuclease that initiates mRNA decay (By similarity) 1 41 test Erf family 1 22 test Essential cell division protein (By similarity) 1 6 test Essential for recycling GMP and indirectly, cGMP (By similarity) 1 6 test Esterase lipase 1 23 test Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) 1 7 test Exodeoxyribonuclease III 1 7 test FAD linked oxidase domain protein 1 3 test FMN-binding protein 1 2 test FMN-dependent alpha-hydroxy acid dehydrogenase 1 34 test FeS assembly protein SUFB 1 27 test Fibronectin-binding protein 1 33 test First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) 1 16 test Flavodoxin 1 12 test Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) 1 6 test Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) 1 5 test GDSL-like Lipase/Acylhydrolase 1 13 test GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) 1 22 test Glucose uptake protein 1 23 test Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) 1 17 test Glycerate kinase 1 18 test Glycerol-3-phosphate cytidylyltransferase 1 7 test Glycolate oxidase subunit 1 49 test Glycosyl transferase 1 42 test Glycosyl transferase, wecb taga cpsf family 1 22 test Glycyl-tRNA synthetase beta subunit 1 76 test GntR family transcriptional regulator 1 17 test GtrA-like protein 1 9 test Guanylate kinase 1 7 test H( )-stimulated, divalent metal cation uptake system (By similarity) 1 30 test HAD-superfamily hydrolase subfamily IA variant 3 1 15 test HTH_ARAC 1 35 test Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) 1 9 test Heat shock protein 1 12 test Helicase, RecD TraA family 1 54 test Hemolysin A 1 16 test Hnh endonuclease 1 16 test Hydrolase, tatD family 1 26 test Hydroxymethylglutaryl-CoA synthase 1 53 test IIC component 1 32 test IIa component 1 18 test IS66 Orf2 family protein 1 6 test Inherit from COG: Competence protein 1 11 test Inherit from COG: Membrane 1 13 test Inherit from COG: Protein of unknown function (DUF1093) 1 4 test Inherit from COG: domain protein 1 17 test Inherit from NOG: Cell Wall 1 2 test Inherit from NOG: LPXTG-motif cell wall anchor domain protein 1 14 test Inherit from NOG: Lpxtg-motif cell wall anchor domain protein 1 2 test Integrase catalytic subunit 1 38 test Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) 1 2 test Involved in DNA repair and RecF pathway recombination (By similarity) 1 17 test Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) 1 12 test Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) 1 10 test Involved in formation and maintenance of cell shape (By similarity) 1 24 test Involved in initiation control of chromosome replication (By similarity) 1 7 test Involved in the binding of tRNA to the ribosomes (By similarity) 1 5 test Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) 1 2 test Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) 1 43 test Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) 1 13 test Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) 1 12 test Involved in the transcription termination process (By similarity) 1 2 test Ion channel 1 25 test Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) 1 21 test K05989 alpha-L-rhamnosidase EC 3.2.1.40 1 2 test Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) 1 31 test L-ascorbate 6-phosphate lactonase 1 35 test L-asparaginase 1 22 test L-ribulose-5-phosphate 4-epimerase 1 31 test L-serine dehydratase 1 11 test L-serine dehydratase, iron-sulfur-dependent, beta subunit 1 15 test L-xylulose 5-phosphate 3-epimerase 1 30 test LemA family 1 18 test Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) 1 31 test Lipase (class 3) 1 2 test Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits 1 10 test Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) 1 2 test Low molecular weight phosphotyrosine protein phosphatase 1 8 test Luciferase-like 1 26 test LysM domain 1 25 test Lyzozyme M1 (1,4-beta-N-acetylmuramidase) 1 13 test Manganese-dependent inorganic pyrophosphatase 1 18 test MarR family Transcriptional regulator 1 6 test Mate efflux family protein 1 33 test Matrixin 1 18 test May be required for sporulation (By similarity) 1 29 test May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) 1 14 test May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) 1 22 test May play a role in the repair of endogenous alkylation damage (By similarity) 1 33 test Membrane bOund o-acyl transferase mboat family protein 1 58 test Membrane-associated zinc metalloprotease 1 31 test Methionine synthase 1 29 test Methyl-accepting chemotaxis family protein 1 5 test Methylates ribosomal protein L11 (By similarity) 1 22 test Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) 1 8 test Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) 1 19 test MgsA AAA+ ATPase C terminal 1 24 test Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) 1 3 test Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) 1 16 test Modulates RecA activity (By similarity) 1 17 test Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) 1 27 test Multicopper oxidase 1 50 test NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) 1 84 test NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) 1 15 test NADPH-dependent glycerol-3-phosphate dehydrogenase 1 31 test NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) 1 2 test NOL1 NOP2 sun family protein 1 27 test Necessary for normal cell division and for the maintenance of normal septation (By similarity) 1 10 test Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) 1 8 test Nicotinate phosphoribosyltransferase 1 38 test NlpC/P60 family 1 30 test NrdI protein 1 7 test Nucleic acid-binding protein 1 16 test Nucleic-acid-binding protein implicated in transcription termination 1 5 test One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) 1 2 test One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) 1 6 test One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) 1 13 test One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) 1 4 test One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal 1 5 test One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) 1 3 test PAP2 Family 1 20 test PG1 protein, homology to Homo sapiens 1 16 test PPIases accelerate the folding of proteins 1 10 test PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) 1 2 test PTS system 1 2 test PTS system glucitol sorbitol-specific 1 11 test PTS system mannose fructose sorbose family transporter subunit IID 1 25 test PTS system sugar-specific permease component 1 37 test Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) 1 10 test Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ 1 13 test Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity) 1 6 test Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) 1 9 test Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) 1 15 test Participates in transcription elongation, termination and antitermination (By similarity) 1 24 test Peptidase C39 family 1 17 test Peptidase M22 Glycoprotease 1 26 test Peptidase S24-like protein 1 2 test Peptidase m42 family protein 1 19 test Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) 1 16 test Permease protein 1 2 test Pfam:Cw-hydrolase 1 11 test Pfam:DapD_N 1 12 test Pfam:Phage_integr_N 1 12 test Pfam:TraG 1 66 test Phage Tail Tape Measure Protein 1 22 test Phage minor structural protein 1 83 test Phage nucleotide-binding protein 1 22 test Phage regulatory protein rha 1 11 test Phi ETA orf 55-like protein 1 59 test Phoh family 1 13 test Phosphate ABC transporter 1 26 test Phosphatidate cytidylyltransferase 1 11 test Phosphoglucomutase phosphomannomutase alpha beta alpha domain 1 46 test Phosphohexokinase 1 22 test Phosphohydrolase 1 36 test Phospholipase, patatin family 1 14 test Phosphopantothenoylcysteine decarboxylase 1 15 test Phosphoribosylglycinamide synthetase 1 37 test Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) 1 24 test Phosphotransferase system, EIIC 1 36 test Plasmid pRiA4b ORF-3 family protein 1 60 test Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) 1 13 test Plays an important role in the de novo pathway of purine nucleotide biosynthesis 1 49 test Polysaccharide Biosynthesis Protein 1 42 test Predicted membrane protein (DUF2335) 1 13 test Preprotein translocase subunit 1 6 test Preprotein translocase subunit SecG 1 2 test Primosomal protein DnaI 1 22 test Primosomal protein n' 1 47 test Probably involved in ribonucleotide reductase function (By similarity) 1 14 test Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) 1 7 test Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) 1 39 test Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) 1 28 test Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) 1 33 test Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) 1 3 test Prophage Lp2 protein 31 1 10 test Protease HtpX homolog 1 26 test Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) 1 8 test Protease synthase and sporulation negative regulatory protein pai 1 1 14 test Protein CrcB homolog 1 3 test Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) 1 7 test Protein of unknown function (DUF1071) 1 3 test Protein of unknown function (DUF1149) 1 11 test Protein of unknown function (DUF1304) 1 7 test Protein of unknown function (DUF1351) 1 24 test Protein of unknown function (DUF1694) 1 8 test Protein of unknown function (DUF2922) 1 8 test Protein of unknown function (DUF3021) 1 14 test Protein of unknown function (DUF3027) 1 4 test Protein of unknown function (DUF3290) 1 10 test Protein of unknown function (DUF554) 1 15 test Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) 1 18 test Putative amino acid metabolism 1 3 test Pyridoxal kinase 1 25 test RNA methyltransferase TrmH family group 3 1 28 test RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) 1 8 test Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) 1 24 test RelA SpoT domain protein 1 14 test Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) 1 49 test Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) 1 56 test Removes the N-terminal methionine from nascent proteins (By similarity) 1 19 test Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) 1 5 test Replication initiator protein 1 20 test Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) 1 21 test Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) 1 21 test Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) 1 51 test Required for chromosome condensation and partitioning (By similarity) 1 95 test Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) 1 12 test Required for maturation of 30S ribosomal subunits (By similarity) 1 6 test Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins 1 14 test Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) 1 20 test Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) 1 23 test Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) 1 12 test Rhomboid family 1 12 test S1 RNA binding domain protein 1 24 test S4 domain protein YaaA 1 2 test SIR2 family 1 23 test SNARE associated Golgi 1 10 test SNARE associated Golgi protein 1 15 test SNARE-like domain protein 1 10 test SNF2 family 1 90 test SPFH domain, Band 7 family protein 1 23 test SUF system FeS assembly protein, NifU family 1 9 test Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) 1 6 test Septum formation initiator 1 9 test Serine Threonine protein kinase 1 2 test Sex pheromone 1 28 test Short-chain dehydrogenase reductase SDR 1 20 test Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) 1 11 test Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) 1 21 test Sortase family 1 2 test Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate 1 37 test Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) 1 44 test Specifically methylates guanosine-37 in various tRNAs (By similarity) 1 14 test Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) 1 11 test Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) 1 17 test Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) 1 9 test SprT-like 1 7 test Sucrose phosphorylase 1 39 test TIGR00159 family 1 23 test TPR repeat-containing protein 1 37 test TRANSCRIPTIONal REGULATOR, LysR family 1 13 test TRNA binding domain protein 1 21 test Teichoic acid glycosylation protein 1 14 test Tetratricopeptide tpr_2 repeat protein 1 21 test The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) 1 33 test The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) 1 9 test The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) 1 14 test This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) 1 9 test This protein binds directly to 23S ribosomal RNA (By similarity) 1 11 test This protein binds to 23S rRNA in the presence of protein L20 (By similarity) 1 2 test This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) 1 5 test This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) 1 7 test This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) 1 39 test This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) 1 7 test TonB-dependent Receptor Plug Domain protein 1 2 test Toxin-antitoxin system, antitoxin component, HicB family 1 6 test Toxin-antitoxin system, toxin component, RelE family 1 3 test Transcription elongation factor NusA 1 33 test Transcriptional regulator, Crp Fnr family 1 11 test Transcriptional regulator, GntR family 1 2 test Transcriptional regulator, Spx MgsR family 1 4 test Transcriptional regulator, TetR family 1 18 test Transcriptional regulatory protein, C terminal 1 9 test Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) 1 8 test Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) 1 21 test Triose-phosphate isomerase 1 24 test Tryptophanyl-tRNA synthetase 1 35 test Type I Restriction 1 2 test Type II restriction modification enzyme methyltransferase 1 54 test UDP-N-acetylglucosamine 2-epimerase 1 26 test UDP-glucose-hexose-1-phosphate uridylyltransferase 1 37 test UPF0052 protein 1 30 test UPF0207 protein 1 16 test UPF0246 protein 1 23 test UPF0291 protein 1 4 test UPF0298 protein 1 9 test UPF0342 protein 1 4 test UPF0346 protein 1 2 test UPF0348 protein 1 26 test UPF0356 protein 1 3 test UPF0397 protein 1 10 test UPF0398 protein 1 16 test UPF0473 protein 1 6 test UPF0756 membrane protein 1 3 test Uncharacterised ACR, COG2135 1 18 test VRR-NUC domain protein 1 4 test VanZ-like protein 1 9 test Vanz family 1 5 test Veg protein 1 6 test Xylose Isomerase Domain-Containing protein 1 24 test YbaK ebsC protein 1 7 test YheO domain protein 1 2 test YhjQ protein 1 8 test YibE F family protein 1 30 test YitT family 1 22 test YjcQ protein 1 10 test YycH protein 1 8 test YycI protein 1 27 test Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) 1 12 test acetyl xylan esterase 1 21 test acetyltransferase, (GNAT) family 1 10 test acyl-CoA thioesterase 1 14 test adenine deaminase 1 57 test aggregation promoting protein 1 7 test alkaline shock protein 1 7 test alpha amylase, catalytic region 1 51 test alpha-galactosidase 1 38 test amino acid ABC transporter 1 34 test aminoglycoside N(3)-acetyltransferase 1 12 test ammonium transporter 1 41 test antiterminator 1 18 test appr-1-p processing domain protein 1 4 test arginyl-trna synthetase 1 2 test asch domain protein 1 9 test aspartate racemase 1 29 test aspartate transcarbamylase 1 17 test aspartyl-trna synthetase 1 42 test atp-dependent rna helicase 1 53 test beta-galactosidase small subunit 1 19 test beta-phospho-glucomutase 1 28 test bifunctional PTS system fructose-specific transporter subunit IIA HPr protein 1 9 test binding-protein-dependent transport systems inner membrane Component 1 13 test brancheD-chain amino acid aminotransferase 1 2 test calcium-transporting ATPase 1 61 test catabolite control protein a 1 27 test cation diffusion facilitator family transporter 1 18 test cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase 1 14 test cell division protein FtsK 1 52 test citrate lyase, alpha 1 16 test copper chaperone 1 5 test cyclopropane-fatty-acyl-phospholipid synthase 1 22 test cysteinyl-tRNA synthetase 1 53 test d-alanyl-d-alanine carboxypeptidase 1 3 test dEAD DEAH box helicase 1 2 test dak2 domain fusion protein ylov 1 36 test dedA family 1 12 test dehydrogenase reductase 1 2 test diacylglycerol kinase, catalytic 1 2 test dihydroorotase 1 27 test dinuclear metal center protein, YbgI family 1 23 test dna replication protein 1 15 test endodeoxyribonuclease RusA 1 6 test endonuclease III 1 7 test exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase (EC 2.7.8.6) 1 21 test fatty acid synthase 1 4 test feS assembly ATPase SufC 1 21 test feS assembly protein SufD 1 13 test ferredoxin--nadp reductase 1 29 test flagellar rod assembly protein muramidase flgj 1 23 test ftsk SpoIIIE family protein 1 18 test fumarate hydratase class II 1 33 test gaf domain protein 1 3 test gatB Yqey 1 6 test glucose-6-phosphate 1-dehydrogenase 1 50 test glycoside hydrolase family 4 1 36 test glycoside hydrolase, family 1 1 21 test glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC 1 24 test glycosyl transferase 1 3 test glycyl-tRNA synthetase, alpha subunit 1 19 test group 1 glycosyl transferase 1 40 test had superfamily (subfamily IIIa) phosphatase 1 5 test had-superfamily hydrolase, subfamily iia 1 19 test head-tail joining protein 1 5 test hicB family 1 14 test histidine triad (HIT) protein 1 8 test histidyl-tRNA synthetase 1 28 test holo-ACP synthase CitX 1 16 test homocysteine methyltransferase 1 18 test homoserine dehydrogenase 1 23 test host cell surface-exposed lipoprotein 1 17 test however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) 1 2 test hydrocarbon binding protein 1 7 test hydrolase, family 1 1 5 test hydrolase, family 31 1 3 test hydroxymethylglutaryL-CoA reductase 1 5 test iic component 1 31 test intracellular protease Pfpi family 1 20 test iron permease, FTR1 1 2 test isochorismatase 1 3 test it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) 1 36 test low temperature requirement protein 1 12 test maltose O-acetyltransferase 1 10 test mannitol-1-phosphate 5-dehydrogenase 1 32 test mechanosensitive ion channel 1 16 test membrAne 1 9 test membrane protein, TerC 1 29 test methionine sulfoxide reductase A 1 2 test multi-transmembrane protein 1 19 test mur ligase 1 33 test n-acetylmuramoyl-l-alanine amidase 1 17 test nh(3)-dependent nad( ) synthetase 1 23 test nicotinamide mononucleotide transporter 1 34 test nitroreductase 1 21 test of methanol dehydrogenase type 1 26 test oxalyl-CoA decarboxylase 1 26 test p-loop domain protein 1 2 test parb-like partition protein 1 29 test peptide deformylase 1 8 test phage Tail Protein 1 7 test phage shock protein C, PspC 1 4 test phage terminase large subunit 1 2 test phenylalanyl-tRNA synthetase (alpha subunit) 1 16 test phosphatase 1 17 test phosphate ABC transporter (Permease 1 22 test phosphate acetyltransferase 1 18 test phosphate-starvation-inducible protein PsiE 1 5 test phospho-beta-glycosidase 1 19 test phosphodiesterase 1 19 test phosphoenolpyruvate carboxykinase 1 40 test phosphoesterase RecJ domain protein 1 34 test phosphohexose isomerase 1 37 test prophage protein 1 18 test protein (oxidative damage protectant) 1 6 test protein family UPF0029, Impact, N-terminal protein 1 17 test protein family UPF0079, ATPase 1 11 test protein, conserved in bacteria 1 2 test pullulanase, type i 1 34 test pur operon repressor 1 21 test purine nucleoside phosphorylase 1 2 test putrescine abc transporter 1 17 test replication initiation and membrane attachment protein 1 40 test restriction endonuclease 1 2 test restriction enzyme 1 6 test rhodanese family 1 4 test riboflavin biosynthesis protein ribF 1 30 test riboflavin synthase, subunit alpha 1 14 test ribonuclease BN 1 18 test ribosomal RNA small subunit methyltransferase b 1 34 test ribosomal subunit Interface protein 1 16 test ribulose-phosphate 3-epimerase 1 3 test rrna methyltransferase 1 15 test sagb-type dehydrogenase domain protein 1 35 test scp-like extracellular 1 4 test secreted protein 1 33 test sensor protein 1 39 test serine protease 1 47 test single-stranded DNA-binding protein 1 8 test sodium solute 1 44 test solute-binding protein 1 2 test tagatose-6-phosphate kinase 1 15 test that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) 1 93 test thiamine biosynthesis lipoprotein 1 25 test this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) 1 22 test threonyL-tRNA synthetase 1 39 test thymidine kinase 1 9 test tpr repeat-containing protein 1 16 test transcriptioN-repair coupling factor 1 123 test transcriptional regulator MERR family 1 25 test transcriptional regulatory protein 1 15 test triphosphoribosyl-dephospho-CoA synthase 1 21 test trp repressor binding protein 1 4 test type iii restriction protein res subunit 1 104 test uracil-dna glycosylase 1 18 test ybak prolyl-trna synthetase 1 14